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1.
Artigo em Inglês | MEDLINE | ID: mdl-36417746

RESUMO

Detection Transformer (DETR) and Deformable DETR have been proposed to eliminate the need for many hand-designed components in object detection while demonstrating good performance as previous complex hand-crafted detectors. However, their performance on Video Object Detection (VOD) has not been well explored. In this paper, we present TransVOD, the first end-to-end video object detection system based on simple yet effective spatial-temporal Transformer architectures. The first goal of this paper is to streamline the pipeline of current VOD, effectively removing the need for many hand-crafted components for feature aggregation, e.g., optical flow model, relation networks. Besides, benefited from the object query design in DETR, our method does not need post-processing methods such as Seq-NMS. In particular, we present a temporal Transformer to aggregate both the spatial object queries and the feature memories of each frame. Our temporal transformer consists of two components: Temporal Query Encoder (TQE) to fuse object queries, and Temporal Deformable Transformer Decoder (TDTD) to obtain current frame detection results. These designs boost the strong baseline deformable DETR by a significant margin (3 %-4 % mAP) on the ImageNet VID dataset. TransVOD yields comparable performances on the benchmark of ImageNet VID. Then, we present two improved versions of TransVOD including TransVOD++ and TransVOD Lite. The former fuses object-level information into object query via dynamic convolution while the latter models the entire video clips as the output to speed up the inference time. We give detailed analysis of all three models in the experiment part. In particular, our proposed TransVOD++ sets a new state-of-the-art record in terms of accuracy on ImageNet VID with 90.0 % mAP. Our proposed TransVOD Lite also achieves the best speed and accuracy trade-off with 83.7 % mAP while running at around 30 FPS on a single V100 GPU device. Code and models are available at https://github.com/SJTU-LuHe/TransVOD.

2.
Sci Rep ; 12(1): 19513, 2022 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-36376549

RESUMO

Childhood obesity remains one of the most important issues in global health, which is implicated in many chronic diseases. Converging evidence suggests that a higher body mass index during childhood (CBMI) is significantly associated with increased coronary artery disease (CAD) susceptibility in adulthood, which may partly arise from the shared genetic determination. Despite genome-wide association studies (GWASs) have successfully identified some loci associated with CBMI and CAD individually, the genetic overlap and common biological mechanism between them remains largely unexplored. Here, relying on the results from the two large-scale GWASs (n = 35,668 for CBMI and n = 547,261 for CAD), linkage disequilibrium score regression (LDSC) was used to estimate the genetic correlation of CBMI and CAD in the first step. Then, we applied different pleiotropy-informed methods including conditional false discovery rate ([Formula: see text]) and genetic analysis incorporating pleiotropy and annotation (GPA) to detect potentially common loci for childhood obesity and CAD. By integrating the genetic information from the existing GWASs summary statistics, we found a significant positive genetic correlation ([Formula: see text] = 0.127, p = 2E-4) and strong pleiotropic enrichment between CBMI and CAD (LRT = 79.352, p = 5.2E-19). Importantly, 28 loci were simultaneously discovered to be associated with CBMI, and 13 of them were identified as potentially pleiotropic loci by [Formula: see text] and GPA. Those corresponding pleiotropic genes were enriched in trait-associated gene ontology (GO) terms "amino sugar catabolic process", "regulation of fat cell differentiation" and "synaptic transmission". Overall, the findings of the pleiotropic loci will help to further elucidate the common molecular mechanisms underlying the association of childhood obesity and CAD, and provide a theoretical direction for early disease prevention and potential therapeutic targets.


Assuntos
Doença da Artéria Coronariana , Obesidade Pediátrica , Humanos , Criança , Adulto , Estudo de Associação Genômica Ampla/métodos , Doença da Artéria Coronariana/genética , Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único , Obesidade Pediátrica/genética , Pleiotropia Genética
3.
Artigo em Inglês | MEDLINE | ID: mdl-36237121

RESUMO

OBJECTIVES: Observational studies suggest birth weight and childhood obesity are closely associated with age at menarche. However, the relationships between them are currently inconsistent and it remains elusive whether such associations are causal. Therefore, the aim of the study was to investigate whether there existed causal relationships between birth weight, childhood obesity and age at menarche. DESIGN, PATIENTS AND MEASUREMENTS: A two-sample Mendelian randomization (MR) study. The standard inverse variance weighted MR analyses were adopted to evaluate the causal effects of birth weight (n = 143,677), childhood body mass index (BMI) (n = 39,620) on age at menarche (n = 182,416) with summary statistics from large-scale genome-wide association studies (GWASs). Meanwhile, we validated our MR results with some sensitivity analyses including maximum likelihood, weighted-median and MR pleiotropy residual sum and outlier methods. RESULTS: The present study showed that each one standard deviation (1-SD) lower birth weight was predicted to result in a 0.1479 years earlier of age at menarche (ß = .1479, 95% confidence interval [CI] = 0.0422-0.2535; p = 0.0061). We also found that genetically predicted 1-SD increase in childhood BMI was causally associated with early age at menarche (ß = -.3966, 95% CI = -0.5294 to -0.2639; p = 4.73E-09). CONCLUSIONS: Our MR study suggests the causal effect of lower birth weight and higher childhood BMI on the increased risk of earlier menarche. It may be the opportune time to carry out weight control intervention in prenatal and early childhood development periods to prevent early menarche onset, thus decreasing the future adverse consequences.

4.
Curr Alzheimer Res ; 2022 10 19.
Artigo em Inglês | MEDLINE | ID: mdl-36278470

RESUMO

AIMS: Exploring the neurobiological mechanisms of early AD damage Background: The early diagnosis of Alzheimer's disease (AD) has a very important impact on the prognosis of AD. However, the early symptoms of AD are not obvious and difficult to diagnose. Existing studies have rarely explored the mechanism of early AD. AMPARs are early important learning memory-related receptors. However, it is not clear how the expression levels of AMPARs change in early AD. OBJECTIVE: We explored learning memory abilities and AMPAR expression changes in APP/PS1 mice at 4 months, 8 months, and 12 months. METHOD: We used the classic Morris water maze to explore the learning and memory impairment of APP/PS1 mice and used western blotting to explore the changes in AMPARs in APP/PS1 mice. RESULT: We found that memory impairment occurred in APP/PS1 mice as early as 4 months of age, and the impairment of learning and memory gradually became serious with age. The changes in GluA1 and p-GluA1 were most pronounced in the early stages of AD in APP/PS1 mice. CONCLUSION: Our study found that memory impairment in APP/PS1 mice could be detected as early as 4 months of age, and this early injury may be related to GluA1.

5.
Nanomaterials (Basel) ; 12(13)2022 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-35808036

RESUMO

Currently, precious metal group materials are known as the efficient and widely used oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) catalysts. The exorbitant prices and scarcity of the precious metals have stimulated scale exploration of alternative non-precious metal catalysts with low-cost and high performance. Layered double hydroxides (LDHs) are a promising precursor to prepare cost-effective and high-performance catalysts because they possess abundant micropores and nitrogen self-doping after pyrolysis, which can accelerate the electron transfer and serve as active sites for efficient OER. Herein, we developed a new highly active NiFeMn-layered double hydroxide (NFM LDH) based electrocatalyst for OER. Through building NFM hydroxide/oxyhydroxide heterojunction and incorporation of conductive graphene, the prepared NFM LDH-based electrocatalyst delivers a low overpotential of 338 mV at current density of 10 mA cm-2 with a small Tafel slope of 67 mV dec-1, which are superior to those of commercial RuO2 catalyst for OER. The LDH/OOH heterojunction involves strong interfacial coupling, which modulates the local electronic environment and boosts the kinetics of charge transfer. In addition, the high valence Fe3+ and Mn3+ species formed after NaOH treatment provide more active sites and promote the Ni2+ to higher oxidation states during the O2 evolution. Moreover, graphene contributes a lot to the reduction of charge transfer resistance. The combining effects have greatly enhanced the catalytic ability for OER, demonstrating that the synthesized NFM LDH/OOH heterojunction with graphene linkage can be practically applied as a high-performance electrocatalyst for oxygen production via water splitting.

6.
BMC Geriatr ; 22(1): 474, 2022 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-35650518

RESUMO

BACKGROUND: Numerous studies have suggested that lifestyle-related factors are associated with mortality, however limited evidence is available for the Chinese elder population. METHODS: The data of this study was obtained from the Chinese Longitudinal Health Survey (CLHLS) during 2008 - 2018, lifestyle-related factors including body mass index (BMI), smoking, drinking, consumption of vegetables and fruits, physical activity and sleep duration were included as dependent variables in the analysis. A lifestyle risk score was created using six unhealthy behaviors: smoking, drinking, unhealthy weight, physical inactivity, not eat vegetables or fruits and short or prolonged sleep. The Kaplan-Meier curves were used to illustrate the cumulative effect of lifestyle factors on mortality and cox regression models were conducted to estimate the combined effects of lifestyle-related factors on total mortality. RESULTS: The results illustrated that low BMI, smoking, no fruit eating, and no physical inactivity were risk factors for total mortality. KM curves showed significant cumulative effect of unhealthy lifestyle factors on mortality. Compared with participants without any unhealthy factors, the hazard ratio (HR) for participants with six unhealthy factors was 1.335 (1.015,1.757) for all-cause mortality. CONCLUSIONS: This study demonstrated poor adherence to a healthy lifestyle may increase all-cause mortality and specific combinations of lifestyle related factors have different effects on mortality among Chinese elderly population.


Assuntos
Estilo de Vida , Idoso , China/epidemiologia , Estudos de Coortes , Humanos , Comportamento Sedentário , Verduras
7.
Sensors (Basel) ; 22(10)2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35632041

RESUMO

Due to the ever-increasing industrial activity, humans and the environment suffer from deteriorating air quality, making the long-term monitoring of air particle indicators essential. The advances in unmanned aerial vehicles (UAVs) offer the potential to utilize UAVs for various forms of monitoring, of which air quality data acquisition is one. Nevertheless, most current UAV-based air monitoring suffers from a low payload, short endurance, and limited range, as they are primarily dependent on rotary aerial vehicles. In contrast, a fixed-wing UAV may be a better alternative. Additionally, one of the most critical modules for 3D profiling of a UAV system is path planning, as it directly impacts the final results of the spatial coverage and temporal efficiency. Therefore, this work focused on developing 3D coverage path planning based upon current commercial ground control software, where the method mainly depends on the Boustrophedon and Dubins paths. Furthermore, a user interface was also designed for easy accessibility, which provides a generalized tool module that links up the proposed algorithm, the ground control software, and the flight controller. Simulations were conducted to assess the proposed methods. The result showed that the proposed methods outperformed the existing coverage paths generated by ground control software, as it showed a better coverage rate with a sampling density of 50 m.


Assuntos
Poluição do Ar , Tecnologia de Sensoriamento Remoto , Algoritmos , Humanos , Tecnologia de Sensoriamento Remoto/métodos
8.
Vet Microbiol ; 269: 109448, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35533578

RESUMO

Porcine hemagglutinating encephalomyelitis virus (PHEV) is a typical neurotropic betacoronavirus causing digestive disease and/or neurological dysfunction in neonatal pigs. Actin filaments have been identified to implicate in PHEV invasion, but the effects of viral infection on microtubules (MTs) cytoskeleton are unknown. Here, we observed that PHEV infection induced MT depolymerization and was accompanied by the disappearance of microtubule organizing centers. Depolymerization of MTs induced by nocodazole significantly inhibited viral RNA replication, but over-polymerization of MTs induced by paclitaxel did not substantially affect PHEV infection. The expression of histone deacetylase 6 (HDAC6), an important regulator of MT acetylation, progressively increased during PHEV infection. Tramstatin A could alter HDAC6 deacetylase activity to enhance the acetylation of the substrate α-tubulin and MT polymerization, but does not increase PHEV proliferation. These findings suggest that PHEV could subvert host MT cytoskeleton to facilitate infection, and that MT depolymerization negatively affects viral replication independently of HDAC6 activity.


Assuntos
Betacoronavirus 1 , Infecções por Coronavirus , Doenças dos Suínos , Animais , Betacoronavirus , Infecções por Coronavirus/veterinária , Microtúbulos , Suínos , Tubulina (Proteína)/genética , Tubulina (Proteína)/metabolismo , Replicação Viral
9.
J Virol ; 96(1): e0169521, 2022 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-34643429

RESUMO

The replication of coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is closely associated with the endoplasmic reticulum (ER) of infected cells. The unfolded protein response (UPR), which is mediated by ER stress (ERS), is a typical outcome in coronavirus-infected cells and is closely associated with the characteristics of coronaviruses. However, the interaction between virus-induced ERS and coronavirus replication is poorly understood. Here, we demonstrate that infection with the betacoronavirus porcine hemagglutinating encephalomyelitis virus (PHEV) induced ERS and triggered all three branches of the UPR signaling pathway both in vitro and in vivo. In addition, ERS suppressed PHEV replication in mouse neuro-2a (N2a) cells primarily by activating the protein kinase R-like ER kinase (PERK)-eukaryotic initiation factor 2α (eIF2α) axis of the UPR. Moreover, another eIF2α phosphorylation kinase, interferon (IFN)-induced double-stranded RNA-dependent protein kinase (PKR), was also activated and acted cooperatively with PERK to decrease PHEV replication. Furthermore, we demonstrate that the PERK/PKR-eIF2α pathways negatively regulated PHEV replication by attenuating global protein translation. Phosphorylated eIF2α also promoted the formation of stress granules (SGs), which in turn repressed PHEV replication. In summary, our study presents a vital aspect of the host innate response to invading pathogens and reveals attractive host targets (e.g., PERK, PKR, and eIF2α) for antiviral drugs. IMPORTANCE Coronavirus diseases are caused by different coronaviruses of importance in humans and animals, and specific treatments are extremely limited. ERS, which can activate the UPR to modulate viral replication and the host innate response, is a frequent occurrence in coronavirus-infected cells. PHEV, a neurotropic betacoronavirus, causes nerve cell damage, which accounts for the high mortality rates in suckling piglets. However, it remains incompletely understood whether the highly developed ER in nerve cells plays an antiviral role in ERS and how ERS regulates viral proliferation. In this study, we found that PHEV infection induced ERS and activated the UPR both in vitro and in vivo and that the activated PERK/PKR-eIF2α axis inhibited PHEV replication through attenuating global protein translation and promoting SG formation. A better understanding of coronavirus-induced ERS and UPR activation may reveal the pathogenic mechanism of coronavirus and facilitate the development of new treatment strategies for these diseases.


Assuntos
Betacoronavirus 1/fisiologia , Infecções por Coronavirus/metabolismo , Fator de Iniciação 2 em Eucariotos/metabolismo , Grânulos de Estresse/metabolismo , Replicação Viral/fisiologia , eIF-2 Quinase/metabolismo , Animais , Betacoronavirus 1/metabolismo , Linhagem Celular , Infecções por Coronavirus/virologia , Retículo Endoplasmático/metabolismo , Retículo Endoplasmático/ultraestrutura , Estresse do Retículo Endoplasmático , Camundongos , Fosforilação , Biossíntese de Proteínas , Transdução de Sinais , Resposta a Proteínas não Dobradas
10.
Molecules ; 26(22)2021 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-34834078

RESUMO

Photocatalytic degradation, as an emerging method to control environmental pollution, is considered one of the most promising environmental purification technologies. As Tibet is a region with some of the strongest solar radiation in China and even in the world, it is extremely rich in solar energy resources, which is ideal for applying photocatalytic technology to its ecological environment protection and governance. In this study, Na2Ti3O7 nanobelts were prepared via a hydrothermal method and converted to TiO2∙xH2O ion exchange, which was followed by high-temperature calcination to prepare TiO2(B) nanobelts ("B" in TiO2(B) means "Bronze phase"). A simple in situ method was used to generate Ag3PO4 particles on the surface of the TiO2 nanobelts to construct a Ag3PO4/TiO2(B) heterojunction composite photocatalyst. By generating Ag3PO4 nanoparticles on the surface of the TiO2(B) nanobelts to construct heterojunctions, the light absorption range of the photocatalyst was successfully extended from UV (ultraviolet) to the visible region. Furthermore, the recombination of photogenerated electron-hole pairs in the catalyst was inhibited by the construction of the heterojunctions, thus greatly enhancing its light quantum efficiency. Therefore, the prepared Ag3PO4/TiO2(B) heterojunction composite photocatalyst greatly outperformed the TiO2(B) nanobelt in terms of photocatalytic degradation.

11.
Talanta ; 234: 122630, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34364439

RESUMO

We developed a simple and highly-selective method for 5-methylcytosine detection of specific gene sequence based on binary-probe DNA hybridization. The sequence complementary to the target was designed into two probes, and each fragment of binary probes bound to a relatively short sequence of the target, which made it sensitive to the base mismatches introduced by bisulfite treatment. The advantages of a low detection limit of methylation abundance of 0.1% for the fully methylated target and high sensitivity of 10 pM have been proved by the successful design of binary-probe hybridization. The successful design of the binary probes makes it possible to quantify the average methylation levels of five CpG sites. Thirty-two DNA strands containing 5, 4, 3, 2, 1 and 0 CpG sites were successfully analyzed with the same pair of binary probes. The higher the average methylation level of the target was, the higher the degree of the hybridization reaction. Based on the simple construction of the binary-probe hybridization, the developed biosensor exhibited signals proportional to the average methylation level of the vimentin gene and could evaluate the average methylation level of artificial mixtures. Furthermore, the method has been used to detect vimentin methylation in a genomic context with good specificity, which indicated its potential in the pre-diagnosis of methylation related disease.


Assuntos
Técnicas Biossensoriais , Metilação de DNA , DNA , Sondas de DNA/genética , Hibridização de Ácido Nucleico
12.
Molecules ; 26(11)2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-34205895

RESUMO

Hydrogen is regarded to be one of the most promising renewable and clean energy sources. Finding a highly efficient and cost-effective catalyst to generate hydrogen via water splitting has become a research hotspot. Two-dimensional materials with exotic structural and electronic properties have been considered as economical alternatives. In this work, 2D SnSe films with high quality of crystallinity were grown on a mica substrate via molecular beam epitaxy. The electronic property of the prepared SnSe thin films can be easily and accurately tuned in situ by three orders of magnitude through the controllable compensation of Sn atoms. The prepared film normally exhibited p-type conduction due to the deficiency of Sn in the film during its growth. First-principle calculations explained that Sn vacancies can introduce additional reactive sites for the hydrogen evolution reaction (HER) and enhance the HER performance by accelerating electron migration and promoting continuous hydrogen generation, which was mirrored by the reduced Gibbs free energy by a factor of 2.3 as compared with the pure SnSe film. The results pave the way for synthesized 2D SnSe thin films in the applications of hydrogen production.

13.
Gene ; 788: 145644, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-33848579

RESUMO

Ovarian cancer (OV) is one of the most common female malignancies with high morbidity and mortality, but its mechanism is not fully understood. The circadian clock is involved in the regulation of the immune system and the tumor microenvironment, regulating biological processes and behaviors in multiple ways. Circadian rhythm disorders are considered a risk factor for tumorigenesis. Multi-omics analysis was performed to comprehensively illustrate the roles of circadian clock genes in OV, we found that most of circadian clock genes undergo epigenetic alterations in OV and are strongly correlated with overall and progression-free patient survival. These clock genes are mainly involved in the inhibition of Apoptosis pathway, Cell Cycle pathway and DNA Damage Response pathway, as well as the activation of RAS/MAPK pathway and RTK pathway. Drug sensitivity model indicate that the expression of core clock genes may associate with drug resistance. Further, immune infiltrates analysis shows that different mutant forms of core genes can not only suppress immune infiltration, but also affect clinical outcome of ovarian cancer patients. Overall, our results may provide novel insights for the potential selection of immunotherapeutic targets.


Assuntos
Peptídeos e Proteínas de Sinalização do Ritmo Circadiano/genética , Perfilação da Expressão Gênica/métodos , Redes Reguladoras de Genes , Neoplasias Ovarianas/genética , Neoplasias Ovarianas/mortalidade , Relógios Circadianos , Bases de Dados Genéticas , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Prognóstico , Análise de Sequência de RNA , Análise de Sobrevida , Microambiente Tumoral
14.
Phys Chem Chem Phys ; 23(6): 3898-3904, 2021 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-33543205

RESUMO

Due to the low cost, high element abundance and intrinsic safety, potassium-ion batteries (KIBs) have attracted a surge of interest in recent years. Currently, the key challenge and obstacle to the development of KIBs is to find suitable anode materials with large capacity, high rate capability and small lattice changes during the charge/discharge process. MXenes with excellent energy storage properties are promising anode materials for KIBs and their energy performance largely depends on the surface termination. Here, two-dimensional O- and S-terminated V2C MXene anode materials are designed to model high performance potassium-ion batteries. Using first-principles calculations, the structural properties and potential battery performance in KIBs of V2CO2 and V2CS2 are systematically investigated. The inherent metallic nature, a small diffusion barrier, a low average open circuit voltage, and a high theoretical specific capacity (489.93 mA h g-1 of V2CO2 and 200.24 mA h g-1 of V2CS2) demonstrate that both of them are ideal anode materials for KIBs. Meanwhile, we also investigated the mechanism of the difference in energy performance between V2CO2 and V2CS2 at atomic and electronic levels, in other words, the energy performance difference introduced by surface O- and S-terminations.

15.
ACS Omega ; 5(50): 32267-32285, 2020 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-33376864

RESUMO

The Xihu Sag in the East China Sea Shelf Basin is a focus for hydrocarbon exploration and development. Hydrocarbons in the Xihu Sag are believed to have mainly originated from coals in the Paleogene Pinghu Formation (shortened as Pinghu coal). In this study, the hydrocarbon generation potential, origin of organic matter, and depositional setting of the Pinghu coal were analyzed by means of optical microscopic analysis, bulk organic geochemistry, and molecular geochemistry analysis. The results reveal that the maceral compositions of the Pinghu coal are characterized by a predominance of vitrinite (73.91-96.13%) with relatively high contents of liptinite (1.47-23.02%) and only minor amounts of inertinite (0-5.18%). Type II-III kerogen and high values of TOC (total organic carbon) (8.24-56.77%), EOM (extractable organic matter) (14 601-112 259 ppm), and HI (hydrogen index) (178.76-291.18 mg·HC/g·TOC) indicate that the Pinghu coal is both gas- and oil-prone and could not only generate but also expel hydrocarbons. The results of vitrinite reflectance (0.54-0.90%), Tmax (421-453 °C), and biomarker-related parameters, including CPI (carbon preference index) (1.10-1.61), OEP (odd-to-even predominance) (1.09-1.49), 22S/(22S + 22R) for C31 homohopane (0.59-0.62), and 22S/(22S + 22R) for C32 homohopane (0.57-0.60), suggest that these coaly source rocks have entered the hydrocarbon generation threshold, most of which have entered the expulsion threshold. Biomarker-related parameters of ∑n-C21-/∑n-C22+ (0.38-3.62), Pr/Ph (3.33-9.23), Pr/n-C17 (1.91-14.88), Ph/n-C18 (0.35-1.83), 22S/(22S+22R) of C31 homohopane (0.59-0.62), 22S/(22S + 22R) of C32 homohopane (0.57-0.60), 1,2,7-TMN/1,3,7-TMN (0.74-14.39), and 1,2,5-TMN/1,3,6-TMN (2.22-21.07) suggest that organic matter in the Pinghu coal was deposited under relatively oxic peatland conditions characterized by a predominance of terrestrial higher plant input, especially the resin-rich Pinaceae and Taxodiaceae. The absence of combustion-derived PAHs indicates that neither vegetation fire nor peat fire occurred very frequently during the formation of peat. Areas in the Xihu sag with considerable thicknesses of coal should be paid particular attention for future hydrocarbon exploration. From a global perspective, Cenozoic coaly source rocks, which are characterized by a relatively high content of aliphatic components, should be paid special attention for their oil-prone properties related to the advent of conifer plants.

16.
Cad Saude Publica ; 36(11): e00123719, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33237201

RESUMO

This study aimed to illustrate the impact of injury-related deaths on life expectancy in China in 2016 and to identify the high-risk population. Standard life tables were used to calculate life expectancy and cause-eliminated life expectancy by utilizing mortality data from the national mortality surveillance system. In 2016, the life expectancy of Chinese residents was 78.91 years. After eliminating injury-related mortality, the life expectancy of the residents increased by 1.13 years, which was higher in male and rural residents compared with female and urban residents. The life expectancy on the Eastern and Central regions increased slowly compared with the Western region. The greatest influencing factor on life expectancy was road traffic injuries, followed by falls. Falls had a greater impact on life expectancy for children under 5 years old and those aged over 65 years. This study indicates that deaths caused by injury had a noteworthy impact on life expectancy in China. More attention should be paid to road traffic injuries, and effective preventive measures should be taken to reduce deaths related to injury to increase the life expectancy of residents, especially in children under 5 years and adults over 65 years. By reducing the deaths caused by injury, the life expectancy level is likely to further improve.


Assuntos
Expectativa de Vida , População Rural , Adulto , Idoso , Brasil , Causas de Morte , Criança , Pré-Escolar , China/epidemiologia , Feminino , Humanos , Tábuas de Vida , Masculino
17.
ACS Omega ; 5(43): 28382-28392, 2020 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-33163822

RESUMO

Microporous silica (MS) materials are a kind of an emerging and promising adsorbent precursor. MS prepared from vermiculite has the advantages of easy preparation, low cost, and low layer charge. In this study, organo-MS (OMS) modified by a typical gemini surfactant 1,2-bis(hexadecyldimethylammonio)ethane dibromide (G16) is first synthesized and proved to have effective retention capacity toward cationic dyes. Fourier transform infrared spectroscopy, TG-DTG, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Brunauer-Emmett-Teller are used to explore the structural characters of adsorbents. Gradient adsorption of compound MS (MS and OMS) in a binary dye system [methylene blue (MB) and crystal violet (CV)] was investigated. In a single system, the relationship between the adsorption capacity and influencing factors (dye concentration, contact time, temperature, and pH), adsorption kinetics, isotherms, as well as thermodynamics was comprehensively compared to reveal the adsorption mechanism. The adsorption values of MB and CV on MS and OMS are 308 mg g-1 (R = 77.0%, 15 min) and 250 mg g-1 (R = 83.3%), respectively, which may be caused by various intermolecular interactions (electrostatic or hydrophobic interactions) between the dye and adsorbent surface. In a binary system, the improved first spectroscopy method is used to calculate the individual concentration of the dye in the binary system. The total removal efficiency of gradient adsorption reaches as high as 89.5% (MB) and 86.4% (CV). In addition, compound MS can be effectively regenerated by HCl solution for several cycles.

18.
Nanomaterials (Basel) ; 10(9)2020 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-32842700

RESUMO

Bi2Se3 possesses a two-dimensional layered rhombohedral crystal structure, where the quintuple layers (QLs) are covalently bonded within the layers but weakly held together by van der Waals forces between the adjacent QLs. It is also pointed out that Bi2Se3 is a topological insulator, making it a promising candidate for a wide range of electronic and optoelectronic applications. In this study, we investigate the growth of high-quality Bi2Se3 thin films on mica by the molecular beam epitaxy technique. The films exhibited a layered structure and highly c-axis-preferred growth orientation with an XRD rocking curve full-width at half-maximum (FWHM) of 0.088°, clearly demonstrating excellent crystallinity for the Bi2Se3 deposited on the mica substrate. The growth mechanism was studied by using an interface model associated with the coincidence site lattice unit (CSLU) developed for van der Waals epitaxies. This high (001) texture favors electron transport in the material. Hall measurements revealed a mobility of 726 cm2/(Vs) at room temperature and up to 1469 cm2/(Vs) at 12 K. The results illustrate excellent electron mobility arising from the superior crystallinity of the films with significant implications for applications in conducting electrodes in optoelectronic devices on flexible substrates.

19.
Int Immunopharmacol ; 87: 106833, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32739831

RESUMO

BACKGROUND: Osteoporosis (OP) is a common inflammatory disease. The goal of this study was to investigate the effect of IL-1R1 and IL-1RN polymorphisms on OP predisposition among the Chinese Han population. METHODS: Six single nucleotide polymorphisms (SNPs) in IL-1R1 and IL-1RN were genotyped using the Agena MassARRAY platform in 594 OP patients and 599 age- and sex- matched healthy controls. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Multifactor dimensionality reduction (MDR) analysis was used to analyze SNP-SNP interaction. The correlations of genotypes with clinical variables were evaluated using analysis of covariance (ANOVA). RESULTS: Overall, IL-1R1 rs3917225 (OR = 1.40, 95% CI: 1.10-1.80, p = 0.007) was associated with a higher risk for OP, while IL-1RN rs17042888 (OR = 0.55, 95% CI: 0.34-0.90, p = 0.016) was associated with a lower risk. Specifically, the risk association between these polymorphisms and OP risk might be related to age, sex and BMI. Furthermore, rs10490571, rs17042888, rs3181052 and rs452204 were associated with the T scores of the lumbar spine or total hip. CONCLUSION: This study is the first to find that rs10490571, rs956730 and rs3917225 in IL-1R1 and rs17042888 in IL-1RN may be genetic contributors to OP susceptibility among the Chinese Han population. Our findings increase the understanding of the role of IL-1R1 and IL-1RN in the genetic etiology of osteoporosis. Nevertheless, these results should be confirmed in larger cohorts.


Assuntos
/genética , Proteína Antagonista do Receptor de Interleucina 1/genética , Osteoporose/genética , Receptores Tipo I de Interleucina-1/genética , Adulto , Idoso , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único
20.
Anal Chem ; 92(15): 10620-10626, 2020 08 04.
Artigo em Inglês | MEDLINE | ID: mdl-32643365

RESUMO

Reliable multiple single nucleotide polymorphisms (SNPs) detection at low abundance is of great significance for disease diagnosis and biomedical research. Herein, we have developed a novel and simple method for multiple SNPs detection combining solid-phase capture by specific hybridization with online preconcentration of capillary gel electrophoresis-laser-induced fluorescence (CGE-LIF). The method presents an excellent performance due to its favorable traits: the solid-phase short-chain hybridization ensures the high specificity of SNP detection; the effective separation ability of CGE can easily achieve multiplex detection; the simple online preconcentration significantly improves the detection sensitivity of fluorescent probe by nearly 100-fold. For a single SNP target, the assay achieves a limit of detection as low as 0.01-0.02% for three different NRAS mutations in the same codon. For multiple SNP targets, as low as 0.05% abundance can be easily realized. Our method is simple, efficient, ultrasensitive, and universal for multiple SNPs detection without complex enzymatic or chemical ligation reaction, which shows great potential in early clinical diagnosis.


Assuntos
Eletroforese Capilar/métodos , Limite de Detecção , Polimorfismo de Nucleotídeo Único , Códon/genética , Hibridização de Ácido Nucleico
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