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1.
Front Cell Infect Microbiol ; 11: 634915, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33791241

RESUMO

Tuberculosis (TB) is the leading infectious cause of mortality worldwide. However, the diagnosis of TB, especially extrapulmonary TB (EPTB) diagnosis from lesion tissues, remains a challenge. Nucleic acid aptamers are analogous to antibodies and have advantages of easier modification, high specificity, and affinity. Mannose-capped lipoarabinomannan (ManLAM) is a unique surface lipoglycan component or constantly released from mycobacterium tuberculosis (M.tb) cell wall, which makes it a perfect candidate biomarker for TB diagnosis. Our present study aims to establish M.tb ManLAM aptamer-based immunohistochemistry (IHC) method for TB diagnosis. We performed TB diagnosis using 263 formalin-fixed paraffin-embedded tissue samples including 213 TB samples (pulmonary TB (PTB) and EPTB), and 8 samples from latent TB infection (LTBI) high risk subjects, and 42 samples from other non-TB patients with ManLAM aptamer-based IHC and routine laboratory TB diagnostic methods parallelly. The sensitivity and specificity of the ManLAM aptamer-based IHC were 86.38% and 92.86%, with much higher sensitivity than those of mycobacterial culture (9.66%) and acid-fast staining (AFS) (43.01%) and comparability to Interferon-gamma Release Assay (IGRA) (84.38%) and GeneXpert (79.31%). High agreement between ManLAM based-IHC and IGRA or GeneXpert for TB diagnosis were observed. Furthermore, ManLAM aptamer-based IHC combination with other routine TB laboratory diagnostic methods significantly increased the sensitivity up to 88.64%-97.92%. As our knowledge, this is the first report about aptamer-based IHC for disease diagnosis. Thus, ManLAM aptamer-based IHC has potentials for TB diagnosis, including PTB, and EPTB, and assists the diagnosis of LTBI with high effectiveness, feasibility, and easy production.

2.
Cell Rep ; 34(13): 108922, 2021 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-33789111

RESUMO

Hematopoietic stem cells (HSCs) regenerate blood cells upon hematopoietic injuries. During homeostasis, HSCs are maintained in a low reactive oxygen species (ROS) state to prevent exhaustion. However, the role of nitric oxide (NO) in controlling HSC regeneration is still unclear. Here, we find increased NO during HSC regeneration with an accumulation of protein aggregation. S-nitrosoglutathione reductase (GSNOR)-deleted HSCs exhibit a reduced reconstitution capacity and loss of self-renewal after chemotherapeutic injury, which is resolved by inhibition of NO synthesis. Deletion of GSNOR enhances protein S-nitrosylation, resulting in an accumulation of protein aggregation and activation of unfolded protein response (UPR). Treatment of taurocholic acid (TCA), a chemical chaperone, rescues the regeneration defect of Gsnor-/- HSCs after 5-fluorouracil (5-FU) treatment. Deletion of C/EBP homologous protein (Chop) restores the reconstitution capacity of Gsnor-/- HSCs. These findings establish a link between S-nitrosylation and protein aggregation in HSC in the context of blood regeneration.

3.
ISA Trans ; 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33766452

RESUMO

Run-to-failure experiment is efficient and effective to investigate bearing deterioration process. Periodic transient waveform carries rich information of health conditions of bearings but the transient waveform matching is a challenging problem for evaluating bearing fatigue life because the shapes and parameters of the waveform vary with the evolution of the bearing degradation. A wavelet function such as a Morlet wavelet is able to extract essential features from the transient waveform but limited to a single transient component. The multi-wavelet may provide a solution to fit a variety of primary components in the transient waveform, so as to track the degradation trend of the bearing; however, very limited work has been done to address this issue. To bridge the research gap in the transient waveform matching, a novel ascension multi-wavelet method is proposed in this paper for diagnosing the undergoing degradation state and predicting the remaining useful life (RUL) of the bearings. Firstly, the transient waveform was matched using the combination of multiple wavelets. Then, the entropy of the multiple-wavelet signal was calculated to quantify the periodic transients to generate a monotone trend of the bearing degradation. The degradation state of the bearing was identified using the entropy. Lastly, the ensemble learning method was employed to establish an RUL predictor. Both simulation and experiments were carried out to evaluate the proposed method. The analysis results demonstrate satisfactory diagnostics and prognostics performance of the proposed method. The RUL prediction accuracy of the multi-wavelet matching is better than that of the single-wavelet matching.

4.
Medicine (Baltimore) ; 100(11): e24841, 2021 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-33725955

RESUMO

ABSTRACT: Symptom Checklist-90 (SCL-90) is the popular and widely used instrument, whether in mental health screening, psychological consultation, or the diagnosis and estimate of mental illness. In 1984, it was translated from theEnglish version into Chinese and then SCL-90 has been widely used in China. It is a pity that the item text of Chinese version has not been revised since the birth of it until today. We analyzed the Chinese version of the 90-item text from 3 new perspectives: translation, semantic, and cross-cultural, and thought that 18 items should be revised. This study' results have taken one step forward on the basis of previous studies, which will play an important role in improving the quality of Chinese version SCL-90 and improving the mental health level of Chinese people.


Assuntos
Lista de Checagem/normas , Transtornos Mentais/diagnóstico , Testes Psicológicos/normas , Semântica , Avaliação de Sintomas/normas , Grupo com Ancestrais do Continente Asiático/psicologia , China , Comparação Transcultural , Humanos , Psicometria , Reprodutibilidade dos Testes , Traduções
6.
Nat Commun ; 12(1): 1636, 2021 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-33712623

RESUMO

We in-situ observe the ultrafast dynamics of trapped carriers in organic methyl ammonium lead halide perovskite thin films by ultrafast photocurrent spectroscopy with a sub-25 picosecond time resolution. Upon ultrafast laser excitation, trapped carriers follow a phonon assisted tunneling mechanism and a hopping transport mechanism along ultra-shallow to shallow trap states ranging from 1.72-11.51 millielectronvolts and is demonstrated by time-dependent and independent activation energies. Using temperature as an energetic ruler, we map trap states with ultra-high energy resolution down to < 0.01 millielectronvolt. In addition to carrier mobility of ~4 cm2V-1s-1 and lifetime of ~1 nanosecond, we validate the above transport mechanisms by highlighting trap state dynamics, including trapping rates, de-trapping rates and trap properties, such as trap density, trap levels, and capture-cross sections. In this work we establish a foundation for trap dynamics in high defect-tolerant perovskites with ultra-fast temporal and ultra-high energetic resolution.

7.
Nat Commun ; 12(1): 973, 2021 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-33579915

RESUMO

The perovskite solar cell has emerged rapidly in the field of photovoltaics as it combines the merits of low cost, high efficiency, and excellent mechanical flexibility for versatile applications. However, there are significant concerns regarding its operational stability and mechanical robustness. Most of the previously reported approaches to address these concerns entail separate engineering of perovskite and charge-transporting layers. Herein we present a holistic design of perovskite and charge-transporting layers by synthesizing an interpenetrating perovskite/electron-transporting-layer interface. This interface is reaction-formed between a tin dioxide layer containing excess organic halide and a perovskite layer containing excess lead halide. Perovskite solar cells with such interfaces deliver efficiencies up to 22.2% and 20.1% for rigid and flexible versions, respectively. Long-term (1000 h) operational stability is demonstrated and the flexible devices show high endurance against mechanical-bending (2500 cycles) fatigue. Mechanistic insights into the relationship between the interpenetrating interface structure and performance enhancement are provided based on comprehensive, advanced, microscopic characterizations. This study highlights interface integrity as an important factor for designing efficient, operationally-stable, and mechanically-robust solar cells.

8.
BMC Plant Biol ; 21(1): 94, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33588749

RESUMO

BACKGROUND: Acyl-CoA-binding proteins (ACBPs) possess a conserved acyl-CoA-binding (ACB) domain that facilitates binding to acyl-CoA esters and trafficking in eukaryotic cells. Although the various functions of ACBP have been characterized in several plant species, their structure, molecular evolution, expression profile, and function have not been fully elucidated in Zea mays L. RESULTS: Genome-wide analysis identified nine ZmACBP genes in Z. mays, which could be divided into four distinct classes (class I, class II, class III, and class IV) via construction of a phylogenetic tree that included 48 ACBP genes from six different plant species. Transient expression of a ZmACBP-GFP fusion protein in tobacco (Nicotiana tabacum) epidermal cells revealed that ZmACBPs localized to multiple different locations. Analyses of expression profiles revealed that ZmACBPs exhibited temporal and spatial expression changes during abiotic and biotic stresses. Eight of the nine ZmACBP genes were also found to have significant association with agronomic traits in a panel of 500 maize inbred lines. The heterologous constitutive expression of ZmACBP1 and ZmACBP3 in Arabidopsis enhanced the resistance of these plants to salinity and drought stress, possibly through alterations in the level of lipid metabolic and stress-responsive genes. CONCLUSION: The ACBP gene family was highly conserved across different plant species. ZmACBP genes had clear tissue and organ expression specificity and were responsive to both biotic and abiotic stresses, suggesting their roles in plant growth and stress resistance.

9.
Plant Dis ; 2021 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-33591830

RESUMO

Knowledge about virulent phenotypes of Heterodera glycines Ichinohe, 1952 (soybean cyst nematode, SCN) is essential for breeding resistant cultivars and managing this nematode. Heilongjiang Province is the major soybean producing region in China. SCN has been reported in 63 regions in Heilongjiang Province. To determine the prevalence and virulence of phenotypes of SCN, 112 soil samples were collected from soybean fields throughout the province in 2015. SCN was detected in 62 samples (55.4%) of these samples, with population densities ranging from 150 to 41,750 eggs and juveniles per 100 cm3 of soil. Eleven HG types, namely HG 0, 1.2.3.5.7, 1.2.3.7, 1.3.4.7, 1.3.7, 2, 2.5.7, 2.7, 6, 6.7, and 7, were detected. The percentages of SCN populations with female indices greater than ten ranged from 4.8% for PI 437654 to 64.5% for PI 548316. This is the first report of seven of the HG types from Heilongjiang. These results provide guidance for breeding efforts and control strategies to combat SCN.

10.
Sci Total Environ ; 767: 145153, 2021 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-33636793

RESUMO

Hearing loss is a common chronic sensory deficit that has become a major public health concern worldwide. Hearing loss is well documented to be induced by noise and ototoxic drugs, and the association of hearing loss with environmental pollutants has received increasing attention. Organochlorine pesticides (OCPs) are an important group of environmental pollutants that exist ubiquitously in the human body and continue to represent a significant environmental health concern. Our case-control study was performed to explore the association between serum levels of OCPs and the risk of hearing loss in China, including 87 case-control pairs. Serum concentrations of 15 OCPs were measured. Pearson's correlation analysis and principal component analysis of frequently detected (>80%) OCPs showed a different distribution pattern, indicating possible exposure sources/scenarios for the case-control adult population. A higher α-hexachlorocyclohexane (α-HCH) level was a risk factor for an increased prevalence of hearing loss. The risk of hearing loss was increased by approximately 5.25-fold in the highest tertile compared with the lowest tertile. Furthermore, a significant association of the α-HCH level with an increased hearing threshold was observed at mid/high frequencies. This study provided the first evidence indicating that exposure to α-HCH might be a potential risk factor for hearing loss.


Assuntos
Perda Auditiva , Hidrocarbonetos Clorados , Praguicidas , Adulto , Estudos de Casos e Controles , China/epidemiologia , Exposição Ambiental/efeitos adversos , Monitoramento Ambiental , Perda Auditiva/induzido quimicamente , Perda Auditiva/epidemiologia , Humanos , Hidrocarbonetos Clorados/análise , Praguicidas/análise
11.
Med Biol Eng Comput ; 59(2): 457-469, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33515131

RESUMO

Three-dimensional (3D) multimodal magnetic resonance (MR) image registration aims to align similar things in different MR images spatially. Such a technology is useful in auxiliary disease diagnosis and surgical treatment. However, inconsistent intensity correspondence and large initial displacement contribute to the difficulty in registering multimodal MR volumes. A coarse-to-fine method is proposed in this study for pairwise 3D MR image rigid registration. Firstly, the proposed method extracts image feature points to form unregistered point sets and performs coarse registration based on point set registration to reduce the initial displacements of offset images effectively. Then, this method calculates a grey histogram based on voxels in the adaptive region of interest and further improves registration accuracy by maximizing mutual information of coarse-registered images. Some representative registration methods are compared on the basis of three MR image datasets to evaluate the performance of the proposed method. Experimental results show that the proposed method improved more in registration success rate and accuracy compared with conventional registration methods, especially when initial displacements are large.

12.
Nan Fang Yi Ke Da Xue Xue Bao ; 41(1): 100-106, 2021 Jan 30.
Artigo em Chinês | MEDLINE | ID: mdl-33509760

RESUMO

OBJECTIVE: To explore the mechanism by which ginsenoside 20(S)-Rg3 upregulates the expression of tumor suppressor von Hippel-Lindau (VHL) gene in ovarian cancer cells. METHODS: Ovarian cancer cell line SKOV3 treated with 20(S)-Rg3 were examined for mRNA and protein levels of VHL, DNMT1, DNMT3A and DNMT3B by real-time PCR and Western blotting, respectively. The changes in VHL mRNA expression in SKOV3 cells in response to treatment with 5-Aza-CdR, a DNA methyltransferase inhibitor, were detected using real-time PCR. VHL gene promoter methylation was examined with methylation-specific PCR and VHL expression levels were determined with real-time PCR and Western blotting in non-treated or 20(S)-Rg3-treated SKOV3 cells and in 20(S)-Rg3-treated DNMT3A-overexpressing SKOV3 cells. VHL and DNMT3A protein levels were detected by immunohistochemistry in subcutaneous SKOV3 cell xenografts in nude mice. RESULTS: Treatment of SKOV3 cells with 20(S)-Rg3 significantly upregulated VHL and downregulated DNMT3A expressions at both the mRNA and protein levels (P < 0.05) and upregulated DNMT3B expression only at the mRNA level, but did not cause significant changes in either the mRNA or protein level of DNMT1. Treatment of the cells with 2 and 5 µmol/L 5-Aza-CdR obviously increased VHL mRNA expression by by over 3 folds (P < 0.05). 20(S)-Rg3 significantly decreased the methylation level in the promoter region of VHL gene, and this effect was abrogated by DNMT3A overexpression in the cells (P < 0.05). Immunohistochemisty showed a significantly increased VHL expression but a lowered DNMT3A expression in subcutaneous SKOV3 cell xenografts in 20 (S)-Rg3-treated nude mice. CONCLUSIONS: Ginsenoside 20(S)-Rg3 upregulates VHL expression in ovarian cancer cells by suppressing DNMT3A-mediated DNA methylation.


Assuntos
Ginsenosídeos , Neoplasias Ovarianas , Animais , Linhagem Celular Tumoral , Metilação de DNA , Feminino , Expressão Gênica , Ginsenosídeos/farmacologia , Humanos , Camundongos , Camundongos Nus , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/genética , Regiões Promotoras Genéticas , Proteína Supressora de Tumor Von Hippel-Lindau/genética
13.
Int J Legal Med ; 135(3): 817-827, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33392655

RESUMO

Seasonal or monthly databases of the diatom populations in specific bodies of water are needed to infer the drowning site of a drowned body. However, existing diatom testing methods are laborious, time-consuming, and costly and usually require specific expertise. In this study, we developed an artificial intelligence (AI)-based system as a substitute for manual morphological examination capable of identifying and classifying diatoms at the species level. Within two days, the system collected information on diatom profiles in the Huangpu and Suzhou Rivers of Shanghai, China. In an animal experiment, the similarities of diatom profiles between lung tissues and water samples were evaluated through a modified Jensen-Shannon (JS) divergence measure for drowning site inference, reaching a prediction accuracy of 92.31%. Considering its high efficiency and simplicity, our proposed method is believed to be more applicable than existing methods for seasonal or monthly water monitoring of diatom populations from sections of interconnected rivers, which would help police narrow the investigation scope to confirm the identity of an immersed body.

14.
Pest Manag Sci ; 77(1): 568-576, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32815305

RESUMO

BACKGROUND: The soybean cyst nematode (SCN, Heterodera glycines) is the most devastating and yield-limiting pest in soybean worldwide. With the increasing awareness of environmental protection, biological control becomes more and more urgent. The Bacillus megaterium Sneb207 has previously shown the ability to inhibit the movement of SCN, but little is known about its effect on nematode control in agricultural settings. The aim of this study was to evaluate the efficiency of Sneb207 against SCN and investigate the ability of Sneb207 to induce systemic resistance to H. glycines in soybean. RESULTS: The stability and efficiency of SCN control by Sneb207 was assessed in two field experiments. Compared to non-treated control, Sneb207 significantly reduced the number of cysts, SCN juveniles, and eggs, while it promoted soybean growth. Furthermore, results of two pot experiments showed that the number of initial infections of second-stage juveniles were 231.75 and 131.3 after Sneb207 treatment, respectively, lower than control (274.75 and 215.33). Sneb207 reduced the total number of juveniles and females, and lengthened SCN development time. Moreover, through the split-root system and real-time quantitative PCR experiments, we found that Sneb207 induced systemic resistance and enhanced the gene expression of GmACS9b, GmEDS1, GmPAD4, GmSAMT1, and GmNPR1-1 involved in the salicylic acid, jasmonic acid and ethylene pathways at different levels. CONCLUSION: Our results demonstrate that B. megaterium Sneb207 inhibits the invasion, the development, and reproduction of SCN by inducing systemic resistance. The overall outcomes of the present study support B. megaterium Sneb207 as a potential biocontrol agent for H. glycines.


Assuntos
Bacillus megaterium , Cistos , Tylenchoidea , Animais , Doenças das Plantas , Soja
15.
Sci Total Environ ; 750: 141685, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32862004

RESUMO

Human exposure to bisphenol A (BPA) is unavoidable in daily life. Recently, research has showen that BPA could induce oxidative imbalance, thereby causing reproductive toxicity and liver dysfunction. Accumulated evidence has demonstrated that metformin possesses strong anti-oxidative properties. This study aimed to study the mechanism underlying the hepatic-protective effect of metformin on liver injury induced by BPA in rats via the UPLC-MS/MS metabolomics approach. Forty-two male rats were randomly divided into six groups (n = 7), namely the saline group (control), the corn oil group (vehicle), the metformin group (Met), the bisphenol A group (BPA), the bisphenol A and metformin group (BPA + Met), and the bisphenol A and diammonium glycyrrhizinate (positive control) group (BPA + DG). Serum was collected for biochemical analysis and metabolomics, and liver tissue was collected for histopathology and metabolomics in each group. We found that metformin could significantly reduce the levels of liver function enzymes (ALT, AST and GGT) and ameliorate inflammatory cell infiltration and hepatocyte necrosis induced by BPA. On the other hand, metformin could significantly enhance the total antioxidant capacity in BPA rats. Notably, metabolomics data indicated that the principal altered metabolic pathways based on the 26 differential metabolites in liver tissue, and 21 in serum among vehicle, BPA and BPA + Met groups, respectively, including cysteine and methionine metabolism, glutathione metabolism, and arginine biosynthesis and purine metabolism. Additionally, metformin significantly increased cystathionine ß synthase (CBS) and cystathionine γ lyase (CSE), thus reducing serum levels of homocysteine and increasing hepatic levels of cysteine and glutathione in BPA-treated rats. Overall, this study's results provided new insights into the role and mechanism of metformin in BPA-induced liver injury in rats.


Assuntos
Cistationina gama-Liase , Metformina , Animais , Compostos Benzidrílicos/toxicidade , Cromatografia Líquida , Cistationina beta-Sintase/metabolismo , Cistationina gama-Liase/metabolismo , Humanos , Fígado/metabolismo , Masculino , Metformina/toxicidade , Fenóis , Ratos , Espectrometria de Massas em Tandem , Regulação para Cima
16.
Antibiotics (Basel) ; 9(12)2020 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-33255159

RESUMO

China is one of the largest producers of pigs and pork in the world. However, large-scale studies on pig-associated Staphylococcus aureus in relation to healthy pigs, diseased pigs and environment are scarce. The objective of the present study was to characterize and compare S. aureus isolates from healthy pigs, diseased pigs and environment through antimicrobial susceptibility testing, multiple locus sequence typing, spa typing, and antimicrobial resistance gene screening. Results showed all isolates were susceptible to linezolid and vancomycin. However, 66.7% (104/156) isolates were multidrug-resistant by displaying resistance to three or more antibiotics and high rates of resistance to penicillin, tetracycline, clindamycin, and clarithromycin were observed. Of the 20 multilocus sequence types (STs) identified among the isolates, ST9, ST188, and ST7 were most commonly isolated from healthy pigs and environment, while ST1 was most commonly isolated from diseased pigs. In total, 17 spa types were represented among the isolates, while t4792 was most commonly isolated from diseased pigs and t899, t189 were most commonly isolated from healthy pigs and environment. In conclusion, the genotypic and epidemiology characteristics observed among the isolates suggest pigs and pork could be important players in S. aureus dissemination.

17.
Chem Commun (Camb) ; 2020 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-33283795

RESUMO

p-p orbital interaction through Mg(ii) isovalent doping in methylammonium lead chloride perovskite significantly enhances the electronic properties while not affecting the optical bandgap. This chemical behaviour shows promising applications to optoelectronic devices.

18.
Eur J Med Chem ; : 112903, 2020 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-33256948

RESUMO

A growing number of reports suggested that the inhibitor targeting cyclin-dependent kinases (CDK) 2/4/6 can act as a more feasible chemotherapy strategy. In the present paper, a novel PROTAC molecule was developed based on the structure of Ribociclib's derivative. In malignant melanoma cells, the degrader can not only degrade CDK 2/4/6 simultaneously and effectively, but also remarkably induce cell cycle arrest and apoptosis of melanoma cells. Moreover, PROTAC molecules with CRBN ligands always have poor oral bioavailability. We developed the orally bioavailable prodrug for the first time. It would provide general solution for oral administration of the PROTAC molecules, derived from CRBN ligands, for animal test conveniently.

19.
Br J Gen Pract ; 2020 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-33257457

RESUMO

BACKGROUND: Polypharmacy is common in heart failure (HF), whereas its effect on adverse outcomes in patients with HF with preserved ejection fraction (HFpEF) is unclear. AIM: To evaluate the prevalence, prognostic impacts, and predictors of polypharmacy in HFpEF patients. DESIGN AND SETTING: A retrospective analysis performed on patients in the Americas region (including the US, Canada, Argentina, and Brazil) with symptomatic HF and a left ventricular ejection fraction ≥45% in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial, an international, randomised, double-blind, placebo-controlled study conducted during 2006-2013 in six countries. METHOD: Patients were categorised into four groups: controls (<5 medications), polypharmacy (5-9 medications), hyperpolypharmacy, (10- 14 medications), and super hyperpolypharmacy (≥15 medications). The outcomes and predictors in all groups were assessed. RESULTS: Of 1761 participants, the median age was 72 years; 37.5% were polypharmacy, 35.9% were hyperpolypharmacy, and 19.6% were super hyperpolypharmacy, leaving 7.0% having a low medication burden. In multivariable regression models, three experimental groups with a high medication burden were all associated with a reduction in all-cause death, but increased risks of HF hospitalisation and all-cause hospitalisation. Furthermore, several comorbidities (dyslipidemia, thyroid diseases, diabetes mellitus, and chronic obstructive pulmonary disease), a history of angina pectoris, diastolic blood pressure <80 mmHg, and worse heart function (the New York Heart Association functional classification level III and IV) at baseline were independently associated with a high medication burden among patients with HFpEF. CONCLUSION: A high prevalence of high medication burden at baseline was reported in patients with HFpEF. The high medication burden might increase the risk of hospital readmission, but not the mortality.

20.
Artigo em Inglês | MEDLINE | ID: mdl-33373184

RESUMO

The rapid advance of fused-ring electron acceptors (FREAs) has made them a potential substitute to fullerene-based acceptors and offered new avenues for the construction of organic solar cells (OSCs). Nonfused-ring acceptors (NFRAs) could significantly reduce the synthetic cost while achieving reasonable power conversion efficiencies (PCEs). Widely used fullerene acceptors have been applied as a second acceptor to regulate the morphology, absorption, and electron transport. To take full advantage of both nonfullerene and fullerene acceptors at the same time, we rationally designed and synthesized two novel NFRAs with phenyl-C61-butyric acid methyl ester (PCBM) as the lateral pendent. With the incorporation of fullerene pendent in PCBM-C6 and PCBM-C10, varied UV-vis absorption and photoluminescence (PL) quenching behaviors were observed, and isotropic diffraction patterns were obtained via grazing incidence wide-angle X-ray scattering (GIWAXS) measurements. The bulky, spherical, and electronic isotropic fullerene pendent could effectively suppress severe molecular aggregation and form the preferred blend morphology. This strategy significantly improved the efficiencies for exciton separation and charge collection relative to the control acceptor CH3COO-C6. Finally, the Voc, Jsc, and fill factor (FF) of PCBM-C10-based devices were simultaneously improved and an enhanced PCE of 13.55% was accomplished.

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