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1.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 27(6): 683-4, 2011 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-21882477

RESUMO

AIM: To investigate the dynamic changes of MMP-9 and TIMP-1 levels in gingival crevicular fluid during orthodontic tooth movement under orthodontic forces. METHODS: select 20 cases which fit experiment condition. The cases divided randomly into 2 groups, 1- cases for each group. The distal forces of 100g and 250 g were exerted to the canine on the one side of two groups separately. The GCF were taken before activation and at 1, 2, 3, 4, 5, 6, 7 week respectively after initiation of the experiment. The levels of MMP-9 and TIMP-1 in GCF were determined by ELISA. RESULTS: The levels of MMP-9 in A group began to increase at 1 week and reached to its peak value at 3 week after initiation of the experiment, but the level returned to baseline at 7 week. The levels of TIMP-1 in A group began to increase at 1, 2, 3 week and decreased at 4 week after initiation of the experiment, but the level at 6,7 week was higher than that before initiation of the experiment. The level of MMP-9 in A group was higher than that in B group at all times and the level of TIMP-1 in A group was lower than that in B group. CONCLUSION: The level of MMP-9 and TIMP-1 in GCF may play an importance role in maintaining the health, the regular remodeling of the periodontium and the fast-moving of orthodontic tooth.


Assuntos
Líquido do Sulco Gengival/enzimologia , Metaloproteinase 9 da Matriz/metabolismo , Aparelhos Ortodônticos , Inibidor Tecidual de Metaloproteinase-1/metabolismo , Técnicas de Movimentação Dentária , Adolescente , Adulto , Força Compressiva , Análise do Estresse Dentário , Feminino , Humanos , Masculino , Metaloproteinase 9 da Matriz/biossíntese , Estresse Mecânico , Resistência à Tração , Inibidor Tecidual de Metaloproteinase-1/biossíntese
2.
Clin Biomech (Bristol, Avon) ; 26(6): 556-61, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21345556

RESUMO

BACKGROUND: Iliac screw loosening has been a clinical problem in the lumbo-pelvic reconstruction. Although iliac screws are commonly inserted into either upper or lower iliac column, the biomechanical effects of the two fixations and their revision techniques with bone cement remain undetermined. The purpose of this study was to compare the anchoring strengths of the upper and lower iliac screws with and without cement augmentation. METHODS: 5 pairs of formalin fixed cadaveric ilia with the bone mineral density values ranged from 0.82 to 0.97 g/cm(2) were adopted in this study. Using screws with 70-mm length and 7.5-mm diameter, 2 conventional iliac screw fixations and their revision techniques with cement augmentation were sequentially established and tested on the same ilium as follows: upper screw, upper cement screw, lower screw, and lower cement screw. Following 2000 cyclic compressive loading of -300 N to -100 N to the screw on a material testing machine, the maximum pull-out strengths were measured and analyzed. FINDINGS: The average pull-out strengths of upper, upper cement, lower, and lower cement screws were 964 N, 1462 N, 1537 N, and 1964 N, respectively. The lower screw showed significantly higher pull-out strength than the upper one (P=0.008). The cement augmentation notably increased the pull-out strengths of both upper and lower screws. The positive correlation between pull-out strength and bone mineral density value was obtained for the 4 fixations. INTERPRETATION: The lower iliac screw technique should be the preferred choice in lumbo-pelvic stabilization surgery; cement augmentation may serve as a useful salvage technique for iliac screw loosening; preoperative evaluation of bone quality is crucial for predicting fixation strength of iliac screw.


Assuntos
Cimentos para Ossos/química , Parafusos Ósseos , Idoso , Fenômenos Biomecânicos , Densidade Óssea , Feminino , Humanos , Ílio/química , Masculino , Pessoa de Meia-Idade , Ossos Pélvicos/patologia , Pelve/patologia , Estresse Mecânico
3.
Clin Biomech (Bristol, Avon) ; 25(9): 867-72, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20655639

RESUMO

BACKGROUND: Although both single and dual iliac screw techniques are used in spino-pelvic reconstruction following sacrectomy for treating sacral tumors, the basis for choosing between the two techniques for different instability types remains undetermined. The purpose of this study was to evaluate the effects of the extent of sacrectomy on the stability of the lumbo-iliac fixation construct using single and dual iliac screw techniques. METHODS: Nine human L2-pelvic specimens were tested for their intact condition simulated by L3-L5 pedicle screw fixation. Sequential partial sacrectomies and L3-iliac fixation using bilateral single and dual iliac screws were conducted on the same specimens as follows: under-S1 sacrectomy+single screw, under-½S1 sacrectomy+single screw, one-side sacroiliac joint resection+single screw, total sacrectomy+single screw, and total sacrectomy+dual screw. Biomechanical testing was performed on a material testing machine for evaluating the stiffness of the L3-iliac fixation construct in compression and torsion. FINDINGS: Single iliac screw technique was found to effectively restore the local stability in under-½S1 sacrectomy. However, it could not provide adequate stability for further resection of one-side sacroiliac joint in torsion and total sacrectomy in compression (P<0.05). On the other hand, dual iliac screw technique could restore the stability to the intact condition after total sacrectomy in both compression and torsion. INTERPRETATION: The single iliac screw technique for L3-iliac fixation could effectively restore the local stability for under-½S1 sacrectomy. However, for instabilities of the under-½S1 sacrectomy with one-side sacroiliac joint resection or total sacrectomy, the dual iliac screw technique should be considered.


Assuntos
Parafusos Ósseos , Ílio/cirurgia , Fixadores Internos , Adulto , Idoso , Fenômenos Biomecânicos , Feminino , Humanos , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Articulação Sacroilíaca/cirurgia , Sacro/cirurgia , Fusão Vertebral/métodos , Estresse Mecânico
4.
Am J Vet Res ; 70(11): 1326-32, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19878014

RESUMO

OBJECTIVE: To investigate physiologic effects of electroacupuncture (EA) combined with xylazine administration in goats. ANIMALS: 48 healthy crossbred goats. PROCEDURES: Goats were randomly allotted to 8 groups of 3 (nonpregnant and nonlactating) female goats and 3 male goats each. The 8 treatment groups were as follows: 1 EA group, 3 xylazine (0.1, 0.2, and 0.4 mg/kg, IM) groups, 3 EA plus xylazine (0.1, 0.2, and 0.4 mg/kg, IM) groups, and 1 control group. Electroacupuncture was performed for 90 minutes. Xylazine was administered 20 minutes after EA was performed. Pain threshold, heart rate, mean arterial pressure (MAP), respiration rate, and rectal temperature were observed at 0, 5, 25, 45, 65, and 85 minutes after xylazine administration. RESULTS: Xylazine administered at 0.4 mg/kg increased the pain threshold and reduced MAP. Xylazine administered at 0.1, 0.2, or 0.4 mg/kg reduced heart rate, respiration rate, and temperature. Electroacupuncture increased the pain threshold but had no effect on heart rate, MAP, respiratory rate, or rectal temperature. Pain threshold in goats that underwent EA plus xylazine administration was higher than in goats that received EA or xylazine alone. Electroacupuncture combined with xylazine at 0.1 mg/kg did not affect heart rate, MAP, respiratory rate, or rectal temperature. Pain threshold in goats that underwent EA plus xylazine administration at 0.1 mg/kg was higher than in goats given xylazine at 0.4 mg/kg alone. CONCLUSIONS AND CLINICAL RELEVANCE: Electroacupuncture combined with xylazine, even at 0.1 mg/kg, provided analgesia without significantly affecting cardiorespiratory parameters or rectal temperature in goats.


Assuntos
Analgésicos/farmacologia , Eletroacupuntura/veterinária , Cabras , Dor/veterinária , Xilazina/farmacologia , Agonistas alfa-Adrenérgicos/administração & dosagem , Agonistas alfa-Adrenérgicos/farmacologia , Analgésicos/administração & dosagem , Animais , Relação Dose-Resposta a Droga , Feminino , Masculino , Dor/tratamento farmacológico , Xilazina/administração & dosagem
5.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 39(4): 291-3, 2004 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-15454012

RESUMO

OBJECTIVE: To examine the role of Epstein-Barr virus (EBV) infection in benign lymphoepithelial lesions with malignant transformation of salivary glands. METHODS: 2 cases benign lymphoepithelial lesions with focal malignant transformation (BLEL-FMT), 14 cases of malignant lymphoepithelial lesion (MLEL) and 4 cases of benign lymphoepithelial lesion (BLEL) of salivary glands, 4 cases of nonspecific chronic sialadenitis were examined. Sections were cut from the paraffin blocks and performed in situ hybridization (ISH) for EBV encoded small RNA-1 (EBER-1) using 30-base synthesized oligonucleotide probe and polymerase chain reaction (PCR) for BamHI-W regein of EBV DNA (123 bp). RESULTS: In ISH, strong signals for EBER-1 were obtained in most of epithelial cell nuclei in examined specimens of BLEL-FMT, no matter in benign or malignant areas and in all specimens of MLEL (14/14), PCR demonstrated a DNA fragment of 123 kbp in 2 cases of BLEL-FMT and 12 cases of MLEL (12/14). In contrast, there were no significant ISH/PCR signals in examined BLEL and nonspecific chronic sialadenitis. CONCLUSIONS: A few cases of MLEL may arise from BLEL and EBV may plays an important role in the pathogenesis of BLEL-FMT of salivary glands.


Assuntos
Infecções por Vírus Epstein-Barr/virologia , Herpesvirus Humano 4/isolamento & purificação , Neoplasias das Glândulas Salivares/virologia , Humanos , Hibridização In Situ , Reação em Cadeia da Polimerase , Neoplasias das Glândulas Salivares/patologia
6.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 35(4): 506-7, 2004 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-15291112

RESUMO

OBJECTIVE: To determine the prevalence of Epstein-Barr virus (EBV) infection in lymphoepithelial carcinoma (LEC) of salivary glands in Sichuan Chinese and discuss the role of EBV infection in pathogenesis of LEC. METHODS: Paraffin sections of 16 cases of LEC and 4 cases of benign lymphoepithelial lesion (BLEL) of salivary glands, 4 cases of non-specific chronic sialadenitis were examined by in situ hybridization for EBV encoded small RNA-1 (EBER-1) using 30-base synthesized oligonucleotide probe. RESULTS: Strong signals for EBER-1 were obtained in most of tumor cell nuclei in all the specimens of LEC (16/16); in contrast, there were no significant signals observed in the examination of 4 cases of BLEL and 4 cases of non-specific chronic sialadenitis. CONCLUSION: The results indicate that EBV plays an important role in the pathogenesis of LEC of salivary glands in Sichuan Chinese.


Assuntos
Carcinoma/virologia , Infecções por Vírus Epstein-Barr/epidemiologia , Herpesvirus Humano 4/isolamento & purificação , Neoplasias das Glândulas Salivares/virologia , Adulto , China/epidemiologia , Infecções por Vírus Epstein-Barr/virologia , Feminino , Humanos , Hibridização In Situ , Masculino , Pessoa de Meia-Idade
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