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1.
Front Oncol ; 11: 659166, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34722233

RESUMO

Introduction: Circular RNAs (circRNAs) are non-coding RNAs that have the structure of a covalently closed loop. Increasing data have proven that circRNAs can influence the progression and chemotherapy sensitivity of tumors. Therefore, the underlying function and mechanisms of more circRNAs in progression and chemotherapy resistance are important. Methods: We conducted RNA sequencing on five pairs of urothelial carcinoma samples and screened for circRNAs. CircFAM114A2 was found to be low expressed in urothelial carcinoma. The functions of circFAM114A2 in urothelial carcinoma were explored by cell cycle assay, IC50 determination assay, cell proliferation assay, apoptosis assay, and tumorigenesis assay. Results: We discovered that the levels of circFAM114A2 were decreased in urothelial carcinoma cell lines and tissues. According to follow-up data, urothelial carcinoma patients with higher circFAM114A2 expression had better survival. Importantly, the levels of circFAM114A2 were associated with the histological grade of urothelial carcinoma. CircFAM114A2 could inhibit cell proliferation and block more urothelial carcinoma cells in the G1 phase and then increase the sensitivity of urothelial carcinoma to cisplatin chemotherapy. Mechanistically, circFAM114A2 directly sponged miR-222-3p/miR-146a-5p and subsequently influenced the expressions of the downstream target genes P27/P21, which, in turn, inhibited the progression of urothelial carcinoma and increased the sensitivity of cancer cells to cisplatin chemotherapy. Conclusion: CircFAM114A2 could inhibit progression and promote cisplatin sensitivity in urothelial carcinoma through novel circFAM114A2/miR-222-3p/P27 and circFAM114A2/miR-146a-5p/P21 pathways. CircFAM1142 has therefore great potential as a prognostic biomarker and therapeutic target for urothelial carcinoma.

2.
Sci Rep ; 11(1): 22677, 2021 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-34811406

RESUMO

The limit of dynamic endurance during repetitive contractions has been referred to as the point of muscle fatigue, which can be measured by mechanical and electrophysiological parameters combined with subjective estimates of load tolerance for revealing the human real-world capacity required to work continuously. In this study, an isotonic muscular endurance (IME) testing protocol under a psychophysiological fatigue criterion was developed for measuring the retentive capacity of the power output of lower limb muscles. Additionally, to guide the development of electrophysiological evaluation methods, linear and non-linear techniques for creating surface electromyography (sEMG) models were compared in terms of their ability to estimate muscle fatigue. Forty healthy college-aged males performed three trials of an isometric peak torque test and one trial of an IME test for the plantar flexors and knee and hip extensors. Meanwhile, sEMG activity was recorded from the medial gastrocnemius, lateral gastrocnemius, vastus medialis, rectus femoris, vastus lateralis, gluteus maximus, and biceps femoris of the right leg muscles. Linear techniques (amplitude-based parameters, spectral parameters, and instantaneous frequency parameters) and non-linear techniques (a multi-layer perception neural network) were used to predict the time-dependent power output during dynamic contractions. Two mechanical manifestations of muscle fatigue were observed in the IME tests, including power output reduction between the beginning and end of the test and time-dependent progressive power loss. Compared with linear mapping (linear regression) alone or a combination of sEMG variables, non-linear mapping of power loss during dynamic contractions showed significantly higher signal-to-noise ratios and correlation coefficients between the actual and estimated power output. Muscular endurance required in real-world activities can be measured by considering the amount of work produced or the activity duration via the recommended IME testing protocol under a psychophysiological termination criterion. Non-linear mapping techniques provide more powerful mapping of power loss compared with linear mapping in the IME testing protocol.

4.
Int J Genomics ; 2021: 9935986, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34824999

RESUMO

In recent years, increasing evidence shows that circular RNA (circRNA) disorder is closely related to tumorigenesis and cancer progression. However, the regulatory functions of most circRNAs in bladder cancer (BCa) remain unclear. This study was aimed at exploring the molecular regulatory mechanism of circRNAs in BCa. We obtained four datasets of circRNA, microRNA (miRNA), and messenger (mRNA) expression profiles from the Gene Expression Omnibus and The Cancer Genome Atlas microarray databases and identified 434, 367, and 4799/4841 differentially expressed circRNAs, miRNAs, and mRNAs, respectively. With these differentially expressed RNAs, we established a circRNA-miRNA-mRNA targeted interaction network. A total of 18, 24, and 51 central circRNAs, miRNAs, and mRNAs were identified, respectively. Among them, the top 10 mRNAs that had high connectivity with other circRNAs and miRNAs were regarded as hub genes. We detected the expression levels of these 10 mRNAs in 16 pairs of BCa tissues and adjacent normal tissues through quantitative real-time polymerase chain reaction. The differentially expressed mRNAs and central mRNAs were enriched in the processes and pathways that are associated with the growth, differentiation, proliferation, and apoptosis of tumor cells. The outstanding genes (CDCA4, GATA6, LATS2, RHOB, ZBTB4, and ZFPM2) also interacted with numerous drugs, indicating their potency as biomarkers and drug targets. The findings of this study provide a deep understanding of the circRNA-related competitive endogenous RNA regulatory mechanism in BCa pathogenesis.

5.
Rev Sci Instrum ; 92(9): 093301, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34598533

RESUMO

We report scanning magnets manufactured at the Huazhong University of Science and Technology Proton Therapy Facility for use in pencil-beam nozzles in a fixed beamline. Such nozzles allow us to control the trajectory of proton beams to form the requisite radiation field for tumor therapy. Two AC-excited scanning magnets operate at a maximum frequency of 100 and 50 Hz, respectively, generating significant eddy currents that raise the temperature. We use transient electromagnetic analysis and thermal analysis to study the eddy current effect and control the temperature. In this paper, the maximum temperature rise of the scanning magnets is taken as the criterion to find the appropriate depth, shape, and distribution of slits. After the slits are optimized, the temperature rise of the scanning magnet is significantly reduced. Finally, the results of DC performance tests satisfy the requirements of the magnetic field.

6.
Am J Nucl Med Mol Imaging ; 11(4): 260-270, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34513279

RESUMO

18F-FDG PET/CT can provide quantitative characterization with prognostic value for mantle cell lymphoma (MCL). However, detection of MCL is performed manually, which is labor intensive and not a part of the routine clinical practice. This study investigates a deep learning convolutional neural network (DLCNN) for computer-aided detection of MCL on 18F-FDG PET/CT. We retrospectively analyzed 142 baseline 18F-FDG PET/CT scans of biopsy-confirmed MCL acquired between May 2007 and October 2018. Of the 142 scans, 110 were from our institution and 32 were from outside institutions. An Xception-based U-Net was constructed to classify each pixel of the PET/CT images as MCL or not. The network was first trained and tested on the within-institution scans by applying five-fold cross-validation. Sensitivity and false positives (FPs) per patient were calculated for network evaluation. The network was then tested on the outside-institution scans, which were excluded from network training. For the 110 within-institution patients (85 male; median age, 58 [range: 39-84] years), the network achieved an overall median sensitivity of 88% (interquartile range [IQR]: 25%) with 15 (IQR: 12) FPs/patient. Sensitivity was dependent on lesion size and SUVmax but not on lesion location. For the 32 outside-institution patients (24 male; median age, 59 [range: 40-67] years), the network achieved a median sensitivity of 84% (IQR: 24%) with 14 (IQR: 10) FPs/patient. No significant performance difference was found between the within and outside institution scans. Therefore, DLCNN can potentially help with MCL detection on 18F-FDG PET/CT with high sensitivity and limited FPs.

7.
Cancer Cell Int ; 21(1): 453, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34446007

RESUMO

BACKGROUND: Melanoma is an extremely aggressive type of skin cancer and experiencing a expeditiously rising mortality in a current year. Exploring new potential prognostic biomarkers and therapeutic targets of melanoma are urgently needed. The ambition of this research was to identify genetic markers and assess prognostic performance of N6-methyladenosine (m6A) regulators in melanoma. METHODS: Gene expression data and corresponding clinical informations of melanoma patients as well as sequence data of normal controls are collected from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases. Quantitative real-time PCR (qRT-PCR) analysis was carried out to detect the RNA expression of IGF2BP3 in A375 cell line, melanoma tissues, and normal tissues. Western blot, cell proliferation, and migration assays were performed to assess the ability of IGF2BP3 in A375 cell line. RESULTS: Differently expressed m6A regulators between tumor samples and normal samples were analyzed. A three-gene prognostic signature including IGF2BP3, RBM15B, and METTL16 was constructed, and the risk score of this signature was identified to be an independent prognostic indicator for melanoma. In addition, IGF2BP3 was verified to promote melanoma cell proliferation and migration in vitro and associate with lymph node metastasis in clinical samples. Moreover, risk score and the expression of IGF2BP3 were positively associated with the infiltrating immune cells and these hub genes made excellent potential drug targets in melanoma. CONCLUSION: We identified the genetic changes in m6A regulatory genes and constructed a three-gene risk signature with distinct prognostic value in melanoma. This research provided new insights into the epigenetic understanding of m6A regulators and novel therapeutic strategies in melanoma.

8.
Surg Endosc ; 2021 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-34231066

RESUMO

BACKGROUND: Artificial intelligence and computer vision have revolutionized laparoscopic surgical video analysis. However, there is no multi-center study focused on deep learning-based laparoscopic cholecystectomy phases recognizing. This work aims to apply artificial intelligence in recognizing and analyzing phases in laparoscopic cholecystectomy videos from multiple centers. METHODS: This observational cohort-study included 163 laparoscopic cholecystectomy videos collected from four medical centers. Videos were labeled by surgeons and a deep-learning model was developed based on 90 videos. Thereafter, the performance of the model was tested in additional ten videos by comparing it with the annotated ground truth of the surgeon. Deep-learning models were trained to identify laparoscopic cholecystectomy phases. The performance of models was measured using precision, recall, F1 score, and overall accuracy. With a high overall accuracy of the model, additional 63 videos as an analysis set were analyzed by the model to identify different phases. RESULTS: Mean concordance correlation coefficient for annotations of the surgeons across all operative phases was 92.38%. Also, the overall phase recognition accuracy of laparoscopic cholecystectomy by the model was 91.05%. In the analysis set, there was an average surgery time of 2195 ± 896 s, with a huge individual variance of different surgical phases. Notably, laparoscopic cholecystectomy in acute cholecystitis cases had prolonged overall durations, and the surgeon would spend more time in mobilizing the hepatocystic triangle phase. CONCLUSION: A deep-learning model based on multiple centers data can identify phases of laparoscopic cholecystectomy with a high degree of accuracy. With continued refinements, artificial intelligence could be utilized in huge data surgery analysis to achieve clinically relevant future applications.

10.
Angew Chem Int Ed Engl ; 60(38): 21033-21039, 2021 09 13.
Artigo em Inglês | MEDLINE | ID: mdl-34278702

RESUMO

We report that the self-assembly of drug amphiphiles, Evans blue conjugated camptothecin prodrug (EB-CPT), can be modulated by another anticancer drug paclitaxel (PTX), resulting in ultrahigh quality of nanovesicles (NVs) with uniform shape and diameters of around 80 nm with the EB-CPT:PTX weight ratio of 1:1, 1:2, and 1:3, denoted as ECX NVs. Significantly, the co-assembly of EB-CPT and PTX without adding other excipients has nearly 100 % drug loading efficiency (DLE) and ultrahigh drug loading content (DLC) of PTX alone of up to 72.3±1.7 wt % which, to our best knowledge, is among the highest level reported in literature. Moreover, the ECX NVs with the EB-CPT:PTX weight ratio of 1:2 showed remarkable combination index of 0.59 at a level of 50 % efficacy against HCT116 cells in vitro and greatly improved tumor inhibition effect in vivo compared with two clinically approved CPT- and PTX-based anticancer nanomedicines (Onivyde and Abraxane) individually and their combinations.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Camptotecina/farmacologia , Nanomedicina , Paclitaxel/farmacologia , Pró-Fármacos/farmacologia , Antineoplásicos Fitogênicos/síntese química , Antineoplásicos Fitogênicos/química , Camptotecina/síntese química , Camptotecina/química , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Células HCT116 , Humanos , Estrutura Molecular , Paclitaxel/síntese química , Paclitaxel/química , Tamanho da Partícula , Pró-Fármacos/síntese química , Pró-Fármacos/química
11.
Theranostics ; 11(14): 6966-6982, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34093865

RESUMO

Rationale: Sensitive and accurate imaging of cancer is essential for early diagnosis and appropriate treatment. For generally employed magnetic resonance imaging (MRI) in clinic, comprehending how to enhance the contrast effect of T 1 imaging is crucial for improving the sensitivity of cancer diagnosis. However, there is no study ever to reveal the clear mechanism of how to enhance the effect of T 1 imaging and accurate relationships of influencing factors. Herein, this study aims to figure out key factors that affect the sensitivity of T 1 contrast-enhanced MRI (CE-MRI), thereby to realize sensitive detection of tumors with low dose of CAs. Methods: Manganese oxide (MnO) nanoparticles (NPs) with various sizes and shapes were prepared by thermal decomposition. Factors impacting T 1 CE-MRI were investigated from geometric volume, surface area, crystal face to r 2/r 1 ratio. T 1 CE-MR imaging of liver, hepatic and subcutaneous tumors were conducted with MnO NPs of different shapes. Results: The surface area and occupancy rate of manganese ions have positive impacts on the sensitivity of T 1 CE-MRI, while volume and r 2/r 1 ratio have negative effects. MnO octahedrons have a high r 1 value of 20.07 mM-1s-1 and exhibit an excellent enhanced effect in liver T 1 imaging. ZDS coating facilitates tumor accumulation and cellular uptake, hepatic and subcutaneous tumors could be detected with MnO octahedrons at an ultralow dose of 0.4 mg [Mn]/kg, about 1/10 of clinical dose. Conclusions: This work is the first quantitative study of key factors affecting the sensitivity of T 1 CE-MRI of MnO nanoparticles, which can serve as a guidance for rational design of high-performance positive MRI contrast agents. Moreover, these MnO octahedrons can detect hepatic and subcutaneous tumors with an ultralow dose, hold great potential for sensitive and accurate diagnosis of cancer with lower cost, less dosages and side effects in clinic.


Assuntos
Meios de Contraste/química , Neoplasias Hepáticas/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Compostos de Manganês/química , Nanopartículas Metálicas/química , Óxidos/química , Animais , Linhagem Celular Tumoral , Humanos , Neoplasias Hepáticas/diagnóstico , Masculino , Compostos de Manganês/síntese química , Nanopartículas Metálicas/ultraestrutura , Camundongos , Camundongos Endogâmicos BALB C , Microscopia Eletrônica de Transmissão , Óxidos/síntese química , Tamanho da Partícula
12.
Sci Total Environ ; 788: 147675, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34034179

RESUMO

In this work, an integrated system combining non-thermal plasma (NTP) and FeMn catalysts was developed for ethylene oxide (EO) oxidation. The effect of Fe/Mn molar ratio on the oxidation rate of EO and energy yield of the plasma-catalytic process has been investigated as a function of specific energy density (SED). Compared with the case of using plasma alone, the combination of plasma and FeMn catalysts greatly enhanced the reaction performance by the factor of 25.2% to 97.6%. The maximum oxidation rate of 98.8% was achieved when Fe1Mn1 catalyst was placed in the dielectric barrier discharge (DBD) reactor at the SED of 656.1 J·L-1. The highest energy yield of 2.82 g·kWh-1 was obtained at the SED of 323.2 J·L-1 over the Fe1Mn1 catalyst. The interactions between Fe and Mn species resulted in larger specific surface area of the catalyst. Moreover, the reducibility of the catalysts was improved, while more surface adsorbed oxygen (Oads) was detected on the catalyst surfaces. Moreover, the redox cycles between Fe and Mn species facilitated consumption and supplementation of reactive oxygen species, which contributed to the plasma-catalytic oxidation reactions. The major reaction products of plasma-induced EO oxidation over the FeMn catalysts, including CH3COOH, CH3CHO, CH4, C2H6 and C2H4, were observed using the FT-IR analyzer and GC-MS instrument. The reaction mechanisms of EO oxidation were discussed in terms of both gas-phase reaction and catalyst surface reaction. The redox cycles between Fe and Mn species facilitated the plasma reaction and accelerated the deep oxidation of by-products.

13.
Chem Commun (Camb) ; 57(42): 5167-5170, 2021 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-33903867

RESUMO

Aqueous glycerol was used in this study as a liquid-phase hydrogen source for the hydrogenation of CO2. It was found that hydrogen could be efficiently evolved from aqueous glycerol upon highly dispersed Ru on layered double hydroxide (LDH), inducing the transformation of CO2 into formaldehyde under base-free conditions at low temperature.

14.
Oxid Med Cell Longev ; 2021: 6657944, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33791072

RESUMO

Long noncoding RNAs (lncRNAs) have attracted extensive attention due to their regulatory role in various cellular processes. Emerging studies have indicated that lncRNAs are expressed to varying degrees after the growth and development of the nervous system as well as injury and degeneration, thus affecting various physiological processes of the nervous system. In this review, we have compiled various reported lncRNAs related to the growth and development of central and peripheral nerves and pathophysiology (including advanced nerve centers, spinal cord, and peripheral nervous system) and explained how these lncRNAs play regulatory roles through their interactions with target-coding genes. We believe that a full understanding of the regulatory function of lncRNAs in the nervous system will contribute to understand the molecular mechanism of changes after nerve injury and will contribute to discover new diagnostic markers and therapeutic targets for nerve injury diseases.


Assuntos
Sistema Nervoso/metabolismo , RNA Longo não Codificante/genética , Animais , Diferenciação Celular/genética , Humanos , Regeneração Nervosa/genética , Sistema Nervoso/crescimento & desenvolvimento , Doenças do Sistema Nervoso/genética , Doenças do Sistema Nervoso/patologia , Células-Tronco Neurais/metabolismo , RNA Longo não Codificante/metabolismo
16.
J Hazard Mater ; 404(Pt A): 124108, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33032090

RESUMO

Ag-modified vanadium silicate (EVS-Ag) has been regarded as a superior sorbent for elemental mercury (Hg0) capture from coal-fired flue gas. However, the atomic-level reaction mechanism which determines Hg0 adsorption capacity of EVS-Ag sorbent remains elusive. Reaction mechanism and active sites of Hg0 adsorption over EVS-Ag sorbent were studied using density functional theory (DFT) calculations systematically. DFT calculation results indicate that silver exchange shows little effects on the geometric structure of EVS-10 sorbent. Hg0 adsorption on EVS-10 and EVS-Ag surfaces is controlled by the physisorption and chemisorption mechanisms, respectively. Ag2 cluster is determined to be the most active site of Hg0 adsorption over Ag-modified EVS sorbent. The adsorption energy of Hg0 on Ag2 cluster is -51.93 kJ/mol. The orbital hybridization and electron sharing between Ag and Hg atoms are responsible for the strong interaction between EVS-Ag surface and Hg0. HgO prefers to adsorb on Ag2 cluster of EVS-Ag sorbent, and yields an energy release of 306.21 kJ/mol. HgO desorption from EVS-Ag sorbent surface needs a higher external energy, and occurs at the relatively higher temperatures. O2 molecule promotes Hg0 adsorption over EVS-Ag sorbent. HgO species can be easily formed during Hg0 adsorption over EVS-Ag sorbent in the presence of O2.

17.
Mol Ther Nucleic Acids ; 23: 27-41, 2021 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-33376625

RESUMO

N6-methyladenosine (m6A) is the most commonly occurring internal RNA modification to be found in eukaryotic mRNA and serves an important role in various physiological events. AlkB homolog 5 RNA demethylase (ALKBH5), an m6A demethylase, belongs to the AlkB family of dioxygenases and has been shown to specifically demethylate m6A in RNA, which is associated with a variety of tumors. However, its function in bladder cancer remains largely unclear. In the present study, we found that the expression of ALKBH5 was downregulated in bladder cancer tissues and cell lines. Low expression of ALKBH5 was correlated with the worse prognosis of bladder cancer patients. Furthermore, functional assays revealed that knockdown of ALKBH5 promoted bladder cancer cell proliferation, migration, invasion, and decreased cisplatin chemosensitivity in the 5637 and T24 bladder cancer cell lines in vivo and in vitro, whereas ALKBH5 overexpression led to the opposite results. Finally, ALKBH5 inhibited the progression and sensitized bladder cancer cells to cisplatin through a casein kinase 2 (CK2)α-mediated glycolysis pathway in an m6A-dependent manner. Taken together, these findings might provide fresh insights into bladder cancer therapy.

18.
Sci Adv ; 6(50)2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33310853

RESUMO

Artificial antigen-presenting cells (aAPCs) can stimulate CD8+ T cell activation. While nanosized aAPCs (naAPCs) have a better safety profile than microsized (maAPCs), they generally induce a weaker T cell response. Treatment with aAPCs alone is insufficient due to the lack of autologous antigen-specific CD8+ T cells. Here, we devised a nanovaccine for antigen-specific CD8+ T cell preactivation in vivo, followed by reactivation of CD8+ T cells via size-transformable naAPCs. naAPCs can be converted to maAPCs in tumor tissue when encountering preactivated CD8+ T cells with high surface redox potential. In vivo study revealed that naAPC's combination with nanovaccine had an impressive antitumor efficacy. The methodology can also be applied to chemotherapy and photodynamic therapy. Our findings provide a generalizable approach for using size-transformable naAPCs in vivo for immunotherapy in combination with nanotechnologies that can activate CD8+ T cells.

19.
ACS Nano ; 2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33206522

RESUMO

Nanotheranostics based on tumor-selective small molecular prodrugs could be more advantageous in clinical translation for cancer treatment, given its defined chemical structure, high drug loading efficiency, controlled drug release, and reduced side effects. To this end, we have designed and synthesized a reactive oxygen species (ROS)-activatable heterodimeric prodrug, namely, HRC, and nanoformulated it for tumor-selective imaging and synergistic chemo- and photodynamic therapy. The prodrug consists of the chemodrug camptothecin (CPT), the photosensitizer 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH), and a thioketal linker. Compared to CPT- or HPPH-loaded polymeric nanoparticles (NPs), HRC-loaded NPs possess higher drug loading capacity, better colloidal stability, and less premature drug leakage. Interestingly, HRC NPs were almost nonfluorescent due to the strong π-π stacking and could be effectively activated by endogenous ROS once entering cells. Thanks to the higher ROS levels in cancer cells than normal cells, HRC NPs could selectively light up the cancer cells and exhibit much more potent cytotoxicity to cancer cells. Moreover, HRC NPs demonstrated highly effective tumor accumulation and synergistic tumor inhibition with reduced side effects on mice.

20.
Nat Commun ; 11(1): 5421, 2020 10 27.
Artigo em Inglês | MEDLINE | ID: mdl-33110072

RESUMO

The clinical applications of magnetic hyperthermia therapy (MHT) have been largely hindered by the poor magnetic-to-thermal conversion efficiency of MHT agents. Herein, we develop a facile and efficient strategy for engineering encapsulin-produced magnetic iron oxide nanocomposites (eMIONs) via a green biomineralization procedure. We demonstrate that eMIONs have excellent magnetic saturation and remnant magnetization properties, featuring superior magnetic-to-thermal conversion efficiency with an ultrahigh specific absorption rate of 2390 W/g to overcome the critical issues of MHT. We also show that eMIONs act as a nanozyme and have enhanced catalase-like activity in the presence of an alternative magnetic field, leading to tumor angiogenesis inhibition with a corresponding sharp decrease in the expression of HIF-1α. The inherent excellent magnetic-heat capability, coupled with catalysis-triggered tumor suppression, allows eMIONs to provide an MRI-guided magneto-catalytic combination therapy, which may open up a new avenue for bench-to-bed translational research of MHT.


Assuntos
Proteínas de Bactérias/química , Hipertermia Induzida , Nanocompostos/administração & dosagem , Neoplasias/terapia , Animais , Proteínas de Bactérias/administração & dosagem , Proteínas de Bactérias/genética , Proteínas de Bactérias/metabolismo , Catálise , Compostos Férricos/química , Humanos , Hipertermia Induzida/instrumentação , Hipertermia Induzida/métodos , Subunidade alfa do Fator 1 Induzível por Hipóxia/genética , Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo , Magnetismo , Nanopartículas de Magnetita/administração & dosagem , Nanopartículas de Magnetita/química , Masculino , Camundongos Endogâmicos BALB C , Myxococcus xanthus/genética , Myxococcus xanthus/metabolismo , Nanocompostos/química , Neoplasias/genética , Neoplasias/metabolismo , Nanomedicina Teranóstica
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