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1.
JMIR Mhealth Uhealth ; 9(9): e24402, 2021 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-34473067

RESUMO

BACKGROUND: For rehabilitation training systems, it is essential to automatically record and recognize exercises, especially when more than one type of exercise is performed without a predefined sequence. Most motion recognition methods are based on feature engineering and machine learning algorithms. Time-domain and frequency-domain features are extracted from original time series data collected by sensor nodes. For high-dimensional data, feature selection plays an important role in improving the performance of motion recognition. Existing feature selection methods can be categorized into filter and wrapper methods. Wrapper methods usually achieve better performance than filter methods; however, in most cases, they are computationally intensive, and the feature subset obtained is usually optimized only for the specific learning algorithm. OBJECTIVE: This study aimed to provide a feature selection method for motion recognition of upper-limb exercises and improve the recognition performance. METHODS: Motion data from 5 types of upper-limb exercises performed by 21 participants were collected by a customized inertial measurement unit (IMU) node. A total of 60 time-domain and frequency-domain features were extracted from the original sensor data. A hybrid feature selection method by combining filter and wrapper methods (FESCOM) was proposed to eliminate irrelevant features for motion recognition of upper-limb exercises. In the filter stage, candidate features were first selected from the original feature set according to the significance for motion recognition. In the wrapper stage, k-nearest neighbors (kNN), Naïve Bayes (NB), and random forest (RF) were evaluated as the wrapping components to further refine the features from the candidate feature set. The performance of the proposed FESCOM method was verified using experiments on motion recognition of upper-limb exercises and compared with the traditional wrapper method. RESULTS: Using kNN, NB, and RF as the wrapping components, the classification error rates of the proposed FESCOM method were 1.7%, 8.9%, and 7.4%, respectively, and the feature selection time in each iteration was 13 seconds, 71 seconds, and 541 seconds, respectively. CONCLUSIONS: The experimental results demonstrated that, in the case of 5 motion types performed by 21 healthy participants, the proposed FESCOM method using kNN and NB as the wrapping components achieved better recognition performance than the traditional wrapper method. The FESCOM method dramatically reduces the search time in the feature selection process. The results also demonstrated that the optimal number of features depends on the classifier. This approach serves to improve feature selection and classification algorithm selection for upper-limb motion recognition based on wearable sensor data, which can be extended to motion recognition of more motion types and participants.

2.
J Healthc Eng ; 2021: 9930543, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34394900

RESUMO

Cold pathogenic disease is a widespread disease in traditional Chinese medicine, which includes influenza and respiratory infection associated with high incidence and mortality. Discovering effective core drugs in Chinese medicine prescriptions for treating the disease and reducing patients' symptoms has attracted great interest. In this paper, we explore the core drugs for curing various syndromes of cold pathogenic disease from large-scale literature. We propose a core drug discovery framework incorporating word embedding and community detection algorithms, which contains three parts: disease corpus construction, drug network generation, and core drug discovery. First, disease corpus is established by collecting and preprocessing large-scale literature about the Chinese medicine treatment of cold pathogenic disease from China National Knowledge Infrastructure. Second, we adopt the Chinese word embedding model SSP2VEC for mining the drug implication implied in the literature; then, a drug network is established by the semantic similarity among drugs. Third, the community detection method COPRA based on label propagation is adopted to reveal drug communities and identify core drugs in the drug network. We compute the community size, closeness centrality, and degree distributions of the drug network to analyse the patterns of core drugs. We acquire 4681 literature from China national knowledge infrastructure. Twelve significant drug communities are discovered, in which the top-10 drugs in every drug community are recognized as core drugs with high accuracy, and four classical prescriptions for treating different syndromes of cold pathogenic disease are discovered. The proposed framework can identify effective core drugs for curing cold pathogenic disease, and the research can help doctors to verify the compatibility laws of Chinese medicine prescriptions.

3.
J Microsc ; 2021 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-34350998

RESUMO

Trypsin is playing an important role in the processes of cancer proliferation, invasion and metastasis which require the precise information of morphology and mechanical properties on the nano-scale for the related research. In this work, living human hepatoma (SMCC-7721) cells were treated with different concentrations of trypsin solution. The morphology and mechanical properties of the cells were measured via atomic force microscope (AFM). Statistical analyses of measurement data indicated that with the increase of trypsin concentration, the average cell height and the surface roughness were both increased, but the cell viability, the cell surface adhesion and the elasticity modulus were decreased significantly. The force required to puncture the cells was also gradually reduced. It indicates that trypsin not only hydrolyses the proteins between the cell and the substrate but also the membrane proteins. The results offer valuable clues for the cancerous process study, pathological analysis and trypsin inhibitor drug development. And this work provides an effective way for overcoming the cell membrane in drug injection for cell-targeted therapy.

4.
Anal Methods ; 13(28): 3136-3146, 2021 07 28.
Artigo em Inglês | MEDLINE | ID: mdl-34156056

RESUMO

Cancer is currently drawing more and more attention as the leading factor in death worldwide. However, little research has been directed towards investigating the micro/nanoscale mechanical properties of cancer cells treated by targeted drugs to evaluate the model systems of targeted drugs using atomic force microscopy (AFM) nano-indentation, especially in light of the multiple drugs targeting various cancerous cells. This paper aims to compare the mechanical effects of sorafenib tosylate and osimertinib mesylate on hepatoma carcinoma cells and lung cancerous cells using atomic force microscopy from the perspective of a model system based on nano-indentation at the micro/nanoscale, which has rarely been investigated. The Sneddon model is applied to fit the force-distance curves, and the mechanical properties, i.e., Young's moduli, can then be calculated. For the SMMC-7721 cells, osimertinib mesylate is a more effective inhibitor than sorafenib tosylate. For the A549 cells, osimertinib mesylate and sorafenib tosylate both have an obvious inhibitory effect. The experimental results may make possible contributions to the diagnosis and treatment of early-stage cancers.


Assuntos
Fenômenos Mecânicos , Preparações Farmacêuticas , Linhagem Celular , Módulo de Elasticidade , Humanos , Microscopia de Força Atômica
5.
Arch Dermatol Res ; 313(6): 461-471, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32785837

RESUMO

The objective of this meta-analysis was performed to compare the effects of tacrolimus plus phototherapy in the treatment of patients with vitiligo. Relevant studies were identified by searching PubMed, Embase, and Web of Science databases. The main outcomes of interest included excellent response (≥ 75% repigmentation), good response (50-75% repigmentation), moderate response (25%-50% repigmentation), and poor response (< 25% repigmentation). Risk ratio (RR) with 95% confidence intervals (95% CIs) was used to calculate the data. Eleven studies were included in this study. Compared with phototherapy alone, combination treatment of tacrolimus and phototherapy significantly improved excellent response rate (RR = 1.40, 95% CI 1.16, 1.69; P < 0.001) and reduced the poor response rate (RR = 0.37, 95% CI 0.22, 0.61; P = 0.001). However, the good response rate (RR = 1.00, 95% CI 0.59, 1.69, P = 1.000) and moderate response rate (RR = 0.91, 95% CI 0.60, 1.38; P = 0.653) were not significantly different between the two treatments. Subgroup analysis suggested that combination treatment had a higher excellent response rate than phototherapy alone for lesions located in the face and proximal limbs. Both NB-UVB and EL, when added to tacrolimus, resulted in a significantly higher excellent response rate than they were used alone. Meta-regression analysis showed that age was a predictive factor that influenced the effect of combination treatment on an excellent response, in which children had a high excellent response to the treatment. Other demographic and clinical variables, including gender, disease duration, family history, and type of vitiligo, did not have any impact on the treatment effect. Combination treatment with tacrolimus and phototherapy was more effective than phototherapy monotherapy for patients with vitiligo, especially in the lesions located in the face and proximal limbs. More large-scale, well-performed trials are needed to verify our findings.

6.
Clin Rheumatol ; 40(1): 263-277, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32533337

RESUMO

OBJECTIVE: We conducted this updated meta-analysis to evaluate the effects of PRP in patients with knee or hip OA. METHOD: PubMed, Embase, and Web of Science were searched to identify randomized controlled trials (RCTs) that compared the efficacy of PRP with other intra-articular injections. The outcomes of interest included Western Ontario and McMaster (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS), Visual Analog Scale (VAS), Harris Hip Score (HHS), and International Knee Documentation Committee (IKDC). RESULTS: Twenty-four RCTs with 21 at knee OA and three at hip OA were included in this meta-analysis. The PRP injections significantly improved the WOMAC score, VAS score, IKDC score, and HHS score as compared with comparators. The WOMAC pain, stiffness, and physical function scores were also significantly better in the PRP group than in the control group. Most of the evaluated parameters that favored PRP were observed in knee OA but not in hip OA, at short-term (at 1, 2, 3, 6, 12 months) but not long-term follow-up (at 18 months), in RCTs with low risk of bias. CONCLUSIONS: Intra-articular PRP injection provided better effects than other injections for OA patients, especially in knee OA patients, in terms of pain reduction and function improvement at short-term follow-up. Key Points • This updated meta-analysis, based on great sample size and high-quality studies, evaluates the effects of PRP in patients with knee or hip OA. • Intra-articular PRP injection provided better effects than other injections for OA patients. • Most of the evaluated parameters that favored PRP were observed in knee OA at short term (at 1, 2, 3, 6, 12 months).


Assuntos
Osteoartrite do Quadril , Osteoartrite do Joelho , Plasma Rico em Plaquetas , Humanos , Ácido Hialurônico , Injeções Intra-Articulares , Ontário , Osteoartrite do Quadril/terapia , Osteoartrite do Joelho/terapia , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
7.
IEEE J Biomed Health Inform ; 25(7): 2820-2832, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33373310

RESUMO

Adverse drug-drug interaction (ADDI) becomes a significant threat to public health. Despite the detection of ADDIs is experimentally implemented in the early development phase of drug design, many potential ADDIs are still clinically explored by accidents, leading to a large number of morbidity and mortality. Several computational models are designed for ADDI prediction. However, they take no consideration of drug dependency, although many drugs usually produce synergistic effects and own highly mutual dependency in treatments, which contains underlying information about ADDIs and benefits ADDI prediction. In this paper, we design a dependent network to model the drug dependency and propose an attribute supervised learning model Probabilistic Dependent Matrix Tri-Factorization (PDMTF) for ADDI prediction. In particular, PDMTF incorporates two drug attributes, molecular structure and side effect, and their correlation to model the adverse interactions among drugs. The dependent network is represented by a dependent matrix, which is first formulated by the row precision matrix of the predicted attribute matrices and then regularized by the molecular structure similarities among drugs. Meanwhile, an efficient alternating algorithm is designed for solving the optimization problem of PDMTF. Experiments demonstrate the superior performance of the proposed model when compared with eight baselines and its two variants.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Preparações Farmacêuticas , Algoritmos , Interações Medicamentosas , Humanos , Modelos Estatísticos
8.
Stem Cell Res Ther ; 11(1): 379, 2020 09 03.
Artigo em Inglês | MEDLINE | ID: mdl-32883340

RESUMO

BACKGROUND: Liver fibrosis resulting from chronic liver injury is one of the major causes of mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the limitations of cell-based therapy in hepatic disease, while maintaining its advantages. METHODS: In this study, we investigated the effect of human fetal skin-derived stem cell (hFSSC) secretome in the treatment of liver fibrosis. To determine the therapeutic potential of the hFSSC secretome in liver fibrosis, we established the CCl4-induced rat liver fibrosis model and administered hFSSC secretome in vivo. Moreover, we investigated the anti-fibrotic mechanism of hFSSC secretome in hepatic stellate cells (HSCs). RESULTS: Our results showed that hFSSC secretome effectively reduced collagen content in liver, improved the liver function and promoted liver regeneration. Interestingly, we also found that hFSSC secretome reduced liver fibrosis through suppressing the epithelial-mesenchymal transition (EMT) process. In addition, we found that hFSSC secretome inhibited the TGF-ß1, Smad2, Smad3, and Collagen I expression, however, increased the Smad7 expression. CONCLUSIONS: In conclusions, our results suggest that hFSSC secretome treatment could reduce CCl4-induced liver fibrosis via regulating the TGF-ß/Smad signal pathway.


Assuntos
Células-Tronco Fetais , Cirrose Hepática , Animais , Células Estreladas do Fígado , Humanos , Fígado/patologia , Cirrose Hepática/patologia , Cirrose Hepática/terapia , Ratos , Transdução de Sinais , Fator de Crescimento Transformador beta1
9.
Comput Math Methods Med ; 2020: 1862168, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32952598

RESUMO

The Traditional Chinese Medicine (TCM) formula is the main treatment method of TCM. A formula often contains multiple herbs where core herbs play a critical therapeutic effect for treating diseases. It is of great significance to find out the core herbs in formulae for providing evidences and references for the clinical application of Chinese herbs and formulae. In this paper, we propose a core herb discovery model CHDSC based on semantic analysis and community detection to discover the core herbs for treating a certain disease from large-scale literature, which includes three stages: corpus construction, herb network establishment, and core herb discovery. In CHDSC, two artificial intelligence modules are used, where the Chinese word embedding algorithm ESSP2VEC is designed to analyse the semantics of herbs in Chinese literature based on the stroke, structure, and pinyin features of Chinese characters, and the label propagation-based algorithm LILPA is adopted to detect herb communities and core herbs in the herbal semantic network constructed from large-scale literature. To validate the proposed model, we choose chronic glomerulonephritis (CGN) as an example, search 1126 articles about how to treat CGN in TCM from the China National Knowledge Infrastructure (CNKI), and apply CHDSC to analyse the collected literature. Experimental results reveal that CHDSC discovers three major herb communities and eighteen core herbs for treating different CGN syndromes with high accuracy. The community size, degree, and closeness centrality distributions of the herb network are analysed to mine the laws of core herbs. As a result, we can observe that core herbs mainly exist in the communities with more than 25 herbs. The degree and closeness centrality of core herb nodes concentrate on the range of [15, 40] and [0.25, 0.45], respectively. Thus, semantic analysis and community detection are helpful for mining effective core herbs for treating a certain disease from large-scale literature.


Assuntos
Descoberta de Drogas/métodos , Medicamentos de Ervas Chinesas/classificação , Medicamentos de Ervas Chinesas/uso terapêutico , Glomerulonefrite/tratamento farmacológico , Fitoterapia , Algoritmos , Inteligência Artificial , China , Doença Crônica , Biologia Computacional , Mineração de Dados , Bases de Dados de Produtos Farmacêuticos , Descoberta de Drogas/estatística & dados numéricos , Humanos , Conceitos Matemáticos , Medicina Tradicional Chinesa/métodos , Medicina Tradicional Chinesa/estatística & dados numéricos , Semântica
10.
Micron ; 130: 102819, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31896517

RESUMO

Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.


Assuntos
Basófilos/efeitos dos fármacos , Degranulação Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Animais , Basófilos/ultraestrutura , Linhagem Celular Tumoral , Microscopia de Força Atômica , Microscopia Eletrônica de Varredura , Ratos
11.
Cell Transplant ; 28(1): 105-115, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30350716

RESUMO

Radioactive dermatitis is caused by the exposure of skin and mucous membranes to radiation fields. The pathogenesis of radioactive dermatitis is complex and difficult to cure. Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) may serve as a promising candidate for the therapy of cutaneous wounds. The aim of this study was to investigate whether a WJ-MSC-derived conditioned medium (MSC-CM) could be used to treat radiation-induced skin wounds in rats using a radiation-induced cutaneous injury model. The present study was designed to examine MSC-CM therapy in the recovery of radiation-induced skin wounds in vitro and in vivo. Firstly, we prepared the MSC-CM and tested the effects of the MSC-CM on human umbilical vein endothelial cell proliferation in vitro. After that, we used a ß-ray beam to make skin wounds in rats and tested the effects of MSC-CM on cutaneous wound healing in vivo. Our results indicated that MSC-CM secreted factors that promoted HUVEC proliferation, regeneration of sebaceous glands, and angiogenesis. Importantly, MSC-CM promoted wound healing in excess of the positive control (epidermal growth factor), with no, or smaller, scar formation. In conclusion, MSC-CM significantly accelerated wound closure and enhanced the wound healing quality. MSC-CM has a beneficial therapeutic effect on radiation-induced cutaneous injury skin in rats and in this way MSC-CM may serve as a basis of a novel cell-free therapeutic approach for radiation dermatitis.


Assuntos
Meios de Cultivo Condicionados/farmacologia , Células-Tronco Mesenquimais/citologia , Cicatrização/efeitos dos fármacos , Animais , Dermatite/terapia , Humanos , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais/efeitos dos fármacos , Ratos , Pele/citologia , Dermatopatias/terapia
12.
Food Funct ; 10(1): 151-162, 2019 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-30516208

RESUMO

Previous studies suggested the anti-diabetic effect of mogrosides in type 1 diabetes. To evaluate the potential effect of mogrosides in type 2 diabetes, we herein investigated the hypoglycemic and hypolipidemic effects and the underlying mechanism of mogroside-rich extract (MGE) using a high-fat diet in combination with streptozotocin (STZ)-induced diabetic model. MGE feeding for 5 weeks did not result in any obvious impact on the body weight and energy intake, but caused a moderate decrease of organ index in diabetic mice. MGE-supplemented diabetic mice showed a notable reduction of fasting blood glucose (FBG), glycated serum protein (GSP), serum insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and serum atherogenic lipid profiles in a dose-dependent manner, whereas significant increases in the anti-atherogenic lipid profile, insulin sensitivity, glucose and insulin tolerance capacity with high dose (300 mg kg-1) MGE were observed (P < 0.01). Besides, hepatocyte polymorphism, lipid accumulation and steatosis were ameliorated and restored to near normal at the high dose. Furthermore, hepatic 5'AMP-activated protein kinase (AMPK) signaling was dose-dependently activated. Accordingly, the mRNA levels of hepatic gluconeogenic and lipogenic genes were downregulated and fat oxidation-associated genes were upregulated. These findings suggest that the hypoglycemic and hypolipidemic activities of MGE are probably attributed to the attenuation of insulin resistance and activation of hepatic AMPK signaling.


Assuntos
Cucurbitaceae/química , Diabetes Mellitus Tipo 2/tratamento farmacológico , Glucosídeos/administração & dosagem , Hipoglicemiantes/administração & dosagem , Hipolipemiantes/administração & dosagem , Extratos Vegetais/administração & dosagem , Proteínas Quinases/metabolismo , Animais , Glicemia/metabolismo , Diabetes Mellitus Tipo 2/etiologia , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/metabolismo , Dieta Hiperlipídica/efeitos adversos , Frutas/química , Gluconeogênese/efeitos dos fármacos , Glucosídeos/análise , Humanos , Hipoglicemiantes/análise , Hipolipemiantes/análise , Resistência à Insulina , Fígado/efeitos dos fármacos , Fígado/enzimologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Extratos Vegetais/análise , Proteínas Quinases/genética , Estreptozocina
13.
PLoS One ; 13(4): e0195226, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29668688

RESUMO

Anti-community detection in networks can discover negative relations among objects. However, a few researches pay attention to detecting anti-community structure and they do not consider the node degree and most of them require high computational cost. Block models are promising methods for exploring modular regularities, but their results are highly dependent on the observed structure. In this paper, we first propose a Degree-based Block Model (DBM) for anti-community structure. DBM takes the node degree into consideration and evolves a new objective function Q(C) for evaluation. And then, a Local Expansion Optimization Algorithm (LEOA), which preferentially considers the nodes with high degree, is proposed for anti-community detection. LEOA consists of three stages: structural center detection, local anti-community expansion and group membership adjustment. Based on the formulation of DBM, we develop a synthetic benchmark DBM-Net for evaluating comparison algorithms in detecting known anti-community structures. Experiments on DBM-Net with up to 100000 nodes and 17 real-world networks demonstrate the effectiveness and efficiency of LEOA for anti-community detection in networks.


Assuntos
Modelos Teóricos , Algoritmos
14.
Int J Clin Exp Pathol ; 11(2): 981-989, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-31938192

RESUMO

The purpose of this study is to explore the effects of lentivirus-mediated overexpression of the SOCS3 gene on proliferation and apoptosis of fibroblasts-like synoviocytes (FLSs) in rheumatoid arthritis (RA). A total of 20 Lewis rats were randomly assigned into experimental and normal groups. Rats in the experimental group were modeled with adjuvant arthritisand the normal group was given no treatment. After culture for 28 days, rats in the experimental group were sacrificed, and the third-generation FLSs were collected and randomly allocated into SOCS3 group, control group, and blank group. MTT assay was used for detecting cell viability, flow cytometry was used for analysis ofcell apoptosis, and enzyme-linked immunosorbent assay (ELISA) was used to determine levels of inflammatory factors (interleukin [IL]-2, interferon [IFN-γ] and tumor necrosis factor [TNF-α]). MTT assay showed that the optical density of the SOCS3 group was significantly higher than that of the control and blank groups. Flow cytometry showed that the apoptosis rate of FLSs in the SOCS3 group was significantly lower than that in the control and blank groups. The results of ELISA assay showed that the levels of IL-2, IFN-γ and TNF-α in the SOCS3 group were higher than those in the control and blank groups. Our study demonstrates that over-expression of SOCS3 promotes proliferation and inhibits apoptosis of FLSs in RA.

15.
J Craniofac Surg ; 26(2): 537-40, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25692895

RESUMO

PURPOSE: The aim of this study is to provide a new and comprehensive anatomic study of the posterior clinoid process (PCP) as well as data for PCP location to guide the surgeons in endoscopic surgery. MATERIALS AND METHODS: Computed tomography angiography images of 120 PCPs and structures around them in adults were reviewed. The measurement was on coronal, sagittal, and axial planes after multiplanar reconstruction. The length, width, and thickness were accessed for the best understanding of the feature of PCP. The distance from the base of the PCP and the middle lowest point of the sellar floor was measured to find the position of the PCP during the transphenoid approach. RESULT: PCP varies in width and thickness in different portions of it and is closely related to the internal carotid artery and posterior communicating artery, which makes it an important landmark during surgery. CONCLUSION: The shape of PCP is various, and the analysis of its relationship to the important structures around it is of great value. In addition, the preoperative radiological evaluation plays a major role in patients considered for endoscopic sinus surgery. Detailed preoperative analysis of the anatomy of the sphenoid sinus and its boundaries is crucial in facilitating entry to the pituitary fossa and reducing intraoperative complications.


Assuntos
Base do Crânio/anatomia & histologia , Osso Esfenoide/anatomia & histologia , Tomografia Computadorizada Espiral/métodos , Adulto , Idoso , Angiografia , Endoscopia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sela Túrcica/anatomia & histologia , Sela Túrcica/diagnóstico por imagem , Base do Crânio/diagnóstico por imagem , Osso Esfenoide/diagnóstico por imagem , Seio Esfenoidal/anatomia & histologia , Seio Esfenoidal/diagnóstico por imagem , Adulto Jovem
16.
Artigo em Chinês | MEDLINE | ID: mdl-26911073

RESUMO

The maxillary sinus is the largest paranasal sinuses. Foreign bodies of nosal sinus can caused by car accidents, firearm attacks, or iatrogeniccause. We reported two rare cases of foreign body of pulp needle and loach. The clinical manifestations might include facial numbness, facial paresthesia, swelling, nasal congestion, facial pain, eye discomfort, limited mouth opening and relapse and etc. Both CT scan and the medical history were helpful in diagnosis. Functional endoscopic surgery would be the first choice of treatment.


Assuntos
Corpos Estranhos/diagnóstico , Seio Maxilar/patologia , Doenças dos Seios Paranasais/patologia , Doença Crônica , Endoscopia , Dor Facial , Humanos , Doenças dos Seios Paranasais/etiologia , Parestesia , Tomografia Computadorizada por Raios X
17.
Artigo em Chinês | MEDLINE | ID: mdl-20545115

RESUMO

OBJECTIVE: To discuss the diagnosis and treatment of child cervical and thoracic angio lymphoma. METHOD: Three cases of huge cervicothoracic angio lymphoma were performed by cervicothoracic approach and median split of sternum under general anesthesia. RESULT: The pathological diagnosis of three cases were angio lymphoma, and there was no recurrence and complication during the follow-up. CONCLUSION: The tumor could be fully exposed by cervicothoracic approach operation, which was the basic guarantee for completely revealed tumor, and no recurrence was found. Other treatment should not be recommend for huge cervicothoracic angio lymphoma.


Assuntos
Linfangioma/cirurgia , Pescoço , Neoplasias Torácicas/cirurgia , Criança , Pré-Escolar , Feminino , Humanos , Linfangioma/diagnóstico , Masculino , Neoplasias Torácicas/diagnóstico
18.
Artigo em Chinês | MEDLINE | ID: mdl-20429378

RESUMO

OBJECTIVE: To introduce recent progress on diagnosis and treatment of benign symmetric lipomatosis (BSL). METHOD: Detailed clinical data of 6 patients with BSL were reviewed and analyzed. We present a summary of the clinical symptoms, physical sign, diagnosis and therapeutic methods of BSL. And related literatures were discussed together. RESULT: All of 6 patients have excessive subcutaneous fat deposit predominantly around neck. One patients had upper extremity localizations. Six patients had the complication of left ventricular diastolic function changes, glucose intolerance or diabetes mellitus, chronic hepatopathy, hyperuricemia and sleep apnea syndrome in one or more. One patients with several symptoms occur simultaneously, another one female patient was accompanied by all symptoms but chronic hepatopathy. Five male patient were alcohol abusers. Total neck lipectomy and abstinence from alcohol were performed on 5 patients. One patient refused treatment. During a follow-up of 3 months to 4 years, one patients was relapsed again, and no recurrence was seen in another 4 patients. All patho logical results were nonencapsulated fat. CONCLUSION: BSL is a lipodystrophy caused by diffuse fatty tissue, symmetry deposition in the neck and shoulder subcutaneous fascia space or deep fascial space. The highest incidence favors to middle-aged man who is alcoholic. Chronic alcohol addiction and typical clinical symptoms help to diagnosis BSL. Lipectomy represents a successful procedure in treating BSL.


Assuntos
Lipomatose Simétrica Múltipla , Adulto , Alcoolismo/complicações , Fáscia/patologia , Feminino , Humanos , Lipectomia , Lipomatose Simétrica Múltipla/complicações , Lipomatose Simétrica Múltipla/diagnóstico , Lipomatose Simétrica Múltipla/cirurgia , Masculino , Pessoa de Meia-Idade , Pescoço/patologia , Ombro/patologia
19.
Artigo em Chinês | MEDLINE | ID: mdl-20398506

RESUMO

OBJECTIVE: To investigate the clinical and pathological features, diagnosis and treatment of Castleman disease (CD). METHODS: Clinical features and related information on diagnosis and treatment of eight cases of CD were retrospectively analyzed. The size of involved lymph nodes ranged from (2 cm x 2 cm x 3 cm) - (4 cm x 3 cm x 2 cm). The lymph nodes were found in level I (1 case), level II (3 cases), level III (3 cases) and level IV (1 case). CT examination in eight patients showed the lesions manifested as ellipse soft masses. Dynamic contrast CT scan in four patients showed ring-enhanced area around the masses. Blood routine examination in eight patients were generally normal, with six patients had mild anemia. RESULTS: Based on the clinical classification, all lesions in this group were localized CD. Histopathology indicated that all lesions were of hyaline-vascular type. After surgery, there was no recurrence during the follow-up period. CONCLUSIONS: Patients with localized CD mainly have lymphadenectasis in a single location. The CT scan can give some evidence. Surgery should be given first priority.


Assuntos
Hiperplasia do Linfonodo Gigante/diagnóstico , Hiperplasia do Linfonodo Gigante/patologia , Linfonodos/patologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pescoço/patologia , Estudos Retrospectivos , Adulto Jovem
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