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1.
J Phys Chem Lett ; 13(1): 371-377, 2022 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-34985294

RESUMO

Metal halide perovskite and its derivatives show great promise in X-ray detection. However, large-scale fabrication of high-quality thick perovskite films is still full of challenges due to the complicated crystal nucleation process that always introduces lots of cracks or pinholes in the final perovskite film. Here, a MA3Bi2I9 film was fabricated by the cost-effective, scalable spraying process, and MACl was used as an additive to effectively tune the crystallization process. As a result, a dense MA3Bi2I9 film constituted by large grains was obtained, which has a high carrier mobility of ∼1 cm2 V-1 s-1 and a large activation energy (Ea) for ion migration of 0.91 eV. Thanks to the outstanding optoelectronic characteristics, X-ray detectors with a configuration of ITO/MA3Bi2I9/Au show a sensitivity of 35 µC Gyair-1 cm-2 and a limit of detection (LoD) of 0.14 µGyairs-1, which is outstanding compared with commercial α-Se detectors.

2.
Artigo em Inglês | MEDLINE | ID: mdl-35024918

RESUMO

Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea, which can cause death in suckling piglets. Vaccines confer only partial protection against new mutant strains, whereas antibodies targeting virus-encoded proteins may be effective prophylactics. In this study, we constructed a recombinant single chain variable fragment (scFv) library from the spleens of two pigs immunized with a recombinant PEDV nucleocapsid (N) protein. Among the positive clones directed against PEDV N protein isolated from the library, four scFvs that showed higher affinity for N were functionally analyzed. These scFvs specifically bound to the PEDV N protein, but not to the transmissible gastroenteritis virus (TGEV) N protein. Their framework regions were highly conserved, whereas their complementarity-determining regions displayed clear diversity. An immunofluorescence assay showed the co-localization of the four scFvs with PEDV N protein in cells. They significantly suppressed PEDV replication, detected with reverse transcription (RT)-quantitative PCR (qPCR; P < 0.01). Two of them significantly reduced the viral titer at 48 hpi and 72 hpi (P < 0.05). In addition, they observably suppressed the production of viral protein at 72 hpi. The expression of interferons, interferon regulatory factor 3 (IRF3), and IRF7 was assessed with RT-qPCR, which indicated that PEDV dramatically suppressed the transcription of interferon-λ1 and IRF7 and that the scFvs significantly upregulated their expression (P < 0.05). These findings facilitated the investigation of the mechanism by which PEDV evaded the host immune response and suggested that these porcine scFvs were potential candidate agents for the prevention and treatment of porcine diarrhea caused by PEDV. KEY POINTS: • Four scFvs targeting PEDV N protein were generated from porcine spleens • These scFvs co-localized with PEDV N protein and suppressed PEDV replication • These scFvs significantly upregulated IFN-λ1 expression.

3.
Sci Total Environ ; 804: 149822, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34517329

RESUMO

Rising CO2 levels will change the behavior and toxicity of soil contaminants. However, it remains unclear whether elevated CO2 levels will change the nanoparticle dissolution or their biological effects in soil. In this study, we used a free-air CO2 enrichment system to examine the effects of elevated CO2 on phytotoxicity and bacterial toxicity of zinc oxide nanoparticles (nZnO) in a paddy soil system. The elevated CO2 changed the nZnO diffraction in soil, slightly increasing its dissolution but remarkably improving its bioavailability. Elevated CO2 did not change Zn accumulation in rice, but still alleviated the adverse effects of nZnO on rice growth, although grain protein, K and P decreased. Moreover, nZnO alone significantly decreased the number of observed soil bacterial species and altered the community organization, while elevated CO2 moderated such changes. Overall, these results increase our understanding of plant response and microbial variation in nanoparticle-contaminated soil under elevated-CO2 conditions. It is necessary to pay attention to soil pollution while facing climate change.


Assuntos
Nanopartículas , Oryza , Óxido de Zinco , Bactérias , Dióxido de Carbono/análise , Dióxido de Carbono/toxicidade , Nanopartículas/toxicidade , Solo , Óxido de Zinco/toxicidade
4.
Sci Total Environ ; 810: 152363, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-34915007

RESUMO

Elevated atmospheric carbon dioxide (eCO2) greatly impacts greenhouse gas (GHG) emissions of CH4 and N2O from rice fields. Although eCO2 generally stimulates GHG emissions in the short term (<5 years) experiments, the responses to long-term (≥10 years) eCO2 remain poorly known. Here we show, through a series of experiments and meta-analysis, that the eCO2 does not necessarily increase CH4 and N2O emissions from rice paddies. In an experiment of free-air CO2 enrichment for 13-15 years, CH4 and N2O emissions were decreased by 11-54% and 33-54%, respectively. The decline of CH4 emissions was related to the reduction of CH4 production and enhancement of CH4 oxidation via raising soil Eh and soil-water interface [O2] under eCO2. Moreover, the eCO2 significantly decreased NH4+-N content, suggesting a reduction of soil nitrification and thereby N2O emissions. A meta-analysis showed that CH4 and N2O emissions were stimulated under short-term eCO2 while reduced under long-term eCO2. The eCO2-induced increase in yield and biomass and the ratio of mcrA genes/pmoA genes declined with eCO2 duration, indicating an eCO2-stimulation of methanogenesis lower than that of methanotrophy over time by fewer increased substrates. Upscaling the results of meta-analysis, the eCO2-induced global paddy CH4 and N2O emissions shifted from an increase (+0.17 Pg CO2-eq year-1) in the short term into a decrease (-0.11 Pg CO2-eq year-1) in the long term. Our findings suggest that the effect of eCO2 on GHG emissions changes over time, and this should be considered in future climate change research.

5.
Neuroscience ; 482: 116-131, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34942314

RESUMO

Aquaporins (AQPs) play critical physiological roles in water balance in the central nervous system (CNS). Aquaporin-4 (AQP4), the principal aquaporin expressed in the CNS, has been implicated in the processing of sensory and pain transmission. Akt signaling is also involved in pain mediation, such as neuroinflammatory pain and bone cancer pain. Previously, we found that expression of AQP4 and p-Akt was altered in the rat spinal cord after spinal nerve ligation (SNL). Here, we further investigated the effects of the AQP4 and Akt pathways in the spinal dorsal horn (SDH) on the pathogenesis of neuropathic pain (NP). Spinal AQP4 was significantly upregulated after SNL and was primarily expressed in astrocytes in the SDH. Inhibition of AQP4 with TGN-020 attenuated the development and maintenance of NP by inhibiting glial activation and anti-neuroinflammatory mechanisms. Moreover, inhibition of AQP4 suppressed astrocyte activation both in the SDH and in primary cultures. Similar to AQP4, we found that p-Akt was also significantly elevated after SNL. Inhibition of Akt with MK2206 suppressed AQP4 upregulation and astrocyte activation both in vivo and in vitro. Furthermore, Akt blockade with MK2206 alleviated NP in the early and late phases after SNL. These results elucidate the mechanisms involved in the roles of Akt/AQP4 signaling in the development and maintenance of NP. AQP4 is likely to be a novel therapeutic target for NP management.

6.
Adv Mater ; : e2109175, 2021 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-34907605

RESUMO

The inherent disadvantage of lead-free potassium sodium niobate (KNN)-based ceramics is the severe temperature instability of piezoelectric charge coefficient (d33 ) caused by the polymorphic phase boundary. Herein, a new concept of structural gradient is proposed by designing compositionally graded multilayer composites with multiple successive phase transitions, to solve the challenge of the inferior temperature stability. The structural gradient ceramics exhibit a superior temperature reliability (d33 remains almost unchanged in the temperature range of 25-100 °C), far outperforming the previously reported KNN counterparts with d33 variation above 27% over the same temperature range. The synergistic contribution of the continuous phase transition, the strain gradient, and the complementary effect of each constituent layer leads to the excellent temperature stability, which is also confirmed by phase-field simulation. These findings are expected to provide a new paradigm for functional material design with outstanding temperature stability.

7.
Vaccines (Basel) ; 9(11)2021 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-34835231

RESUMO

Staphylococcus aureus is a causative agent of bovine mastitis, capable of causing significant economic losses to the dairy industry worldwide. This study focuses on obtaining single-chain fragment variables (scFvs) against the virulence factors of S. aureus and evaluates the protective effect of scFvs on bovine mammary epithelial (MAC-T) cells and mice mammary gland tissues infected by S. aureus. After five rounds of bio-panning, four scFvs targeting four virulence factors of S. aureus were obtained. The complementarity-determining regions (CDRs) of these scFvs exhibited significant diversities, especially CDR3 of the VH domain. In vitro, each of scFvs was capable of inhibiting S. aureus growth and reducing the damage of MAC-T cells infected by S. aureus. Preincubation of MAC-T cells with scFvs could significantly attenuate the effect of apoptosis and necrosis compared with the negative control group. In vivo, the qPCR and ELISA results demonstrated that scFvs reduced the transcription and expression of Tumor Necrosis Factor alpha (TNF-α), interleukin-1ß (IL-1ß), IL-6, IL-8, and IL-18. Histopathology and myeloperoxidase (MPO) results showed that scFvs ameliorated the histopathological damages and reduced the inflammatory cells infiltration. The overall results demonstrated the positive anti-inflammatory effect of scFvs, revealing the potential role of scFvs in the prevention and treatment of S. aureus infections.

8.
Chemosphere ; : 132976, 2021 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-34808202

RESUMO

The effects of pyrolysis temperature on properties and adsorption performance of carbonized bacterial cellulose (CBC) produced from bacterial cellulose at 300, 400, 600 and 800 °C were investigated. As pyrolysis temperature increased, the BET surface area, C and ash contents of CBC increased while its mass yield and the contents of H, N and O decreased. Higher pyrolysis temperature resulted in CBC having more aromatic structure and less hydrophilic. The impacts of pyrolysis temperature, solution pH, contact time and initial concentration on the absorption of Cr(VI) onto CBC were systematically studied as well. The results showed that CBC400 prepared at 400 °C exhibited the highest Cr(VI) adsorption capacity for Cr(VI) up to 250.0 mg/g. The equilibrium adsorption and adsorption kinetics fitted the Langmuir isotherm and pseudo-second-order kinetic models well. The mechanisms of adsorption of Cr(VI) on CBC included electrostatic interaction, π-π interaction and functional groups complexation.

9.
Artigo em Inglês | MEDLINE | ID: mdl-34813411

RESUMO

RATIONALE: It remains unknown whether long-term ozone exposure can impair lung function. OBJECTIVES: To investigate the associations between long-term ozone exposure and adult lung function in China. METHODS: Lung function results and diagnosis of small airways dysfunction (SAD) were collected from a cross-sectional study, China Pulmonary Health Study (N=50,991). We used multivariate linear and logistic regression models to examine the associations of long-term ozone exposure with lung function parameters and SAD, respectively, adjusting for demographic characteristics, individual risk factors, and longitudinal trend. We then performed a stratification analysis by chronic obstructive pulmonary disease (COPD). MEASUREMENTS AND MAIN RESULTS: We observed each 1-standard deviation (SD, 4.9 ppb) increase in warm-season ozone concentrations was associated with a 14.2 mL/s [95% confidence interval (CI): 8.8, 19.6] decrease in forced expiratory flow at 75th percentile of vital capacity and a 29.5 mL/s (95% CI: 19.6, 39.5) decrease in mean forced expiratory flow between the 25th and 75th percentile of vital capacity. The odds ratio of SAD was 1.09 (95% CI: 1.06, 1.11) for a 1-SD increase in warm-season ozone concentrations. Meanwhile, we observed a significant association with a decreased ratio of expiratory volume in 1 second to forced vital capacity (FEV1/FVC) but not with FEV1 or FVC. The association estimates were greater in the COPD group than in the non-COPD group. CONCLUSION: We found independent associations of long-term ozone exposure with impaired small airways function and higher SAD risks, while the associations with airflow obstruction were weak. COPD patients appear to be more vulnerable.

10.
Ann Palliat Med ; 10(9): 9660-9668, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34628891

RESUMO

BACKGROUND: The main aim of this study was to determine some simple but meaningful parameters that indicate immunochemotherapy-related interstitial lung disease (ILD) early in B-cell lymphoma and provide direction to hematologists. METHODS: The clinical and laboratory characteristics, the treatments and outcomes of 21 B-cell lymphoma patients with ILD who underwent rituximab (RTX) -based immunochemotherapy were collected and retrospectively analyzed. RESULTS: More cycles of immunochemotherapy and higher cumulative doses of RTX and doxorubicin hydrochloride liposome conferred a high risk of ILD. Compared to the baseline, patients had a significantly lower white blood cell count (WBC), absolute lymphocyte count (ALC), and albumin level (4.95×109 vs. 6.32×109, 0.71×109 vs. 1.61×109, 34.1 vs. 40.4 g/L; P<0.05), and higher C-reactive protein (CRP), alpha-hydroxybutyrate dehydrogenase (α-HBDH), and lactate dehydrogenase (LDH) (15.36 vs. 7.00 mg/L, 293.0 vs. 163.1 U/L, 361.8 vs. 231.1 U/L; P<0.05) levels at ILD onset. Further, a positive correlation was found between early glucocorticosteroid intervention and the good prognostication of ILD. In addition, an analysis of the prognoses of 2 cases of patients with pneumocystis pneumonia (PCP) infection indicated that after 3 cycles of treatment, patients, especially unfit patients or those who have received ILD glucocorticoid treatment, may need to receive trimethoprim/sulfamethoxazole (TMP/SMX) to prevent PCP. CONCLUSIONS: There was a relationship between variations of blood parameters and the occurrence of ILD which might serve as a warning for B-cell lymphoma patients with immunochemotherapy-related ILD.


Assuntos
Doenças Pulmonares Intersticiais , Linfoma de Células B , Humanos , Doenças Pulmonares Intersticiais/induzido quimicamente , Linfoma de Células B/tratamento farmacológico , Estudos Retrospectivos , Rituximab/efeitos adversos , Combinação Trimetoprima e Sulfametoxazol
11.
Oxid Med Cell Longev ; 2021: 5527137, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34691355

RESUMO

Oxidative stress and inflammatory response are closely related to nephrolithiasis. This study is aimed at exploring whether rosiglitazone (ROSI), a regulator of macrophage (Mp) polarization, could reduce renal calcium oxalate (CaOx) deposition by ameliorating oxidative stress and inflammatory response. Male C57 mice were equally and randomly divided into 7 groups. Kidney sections were collected on day 5 or day 8 after treatment. Pizzolato staining and polarized light optical microscopy were used to detect crystal deposition. PAS staining and TUNEL assay were performed to assess the tubular injury and cell apoptosis, respectively. Gene expression was assessed by immunohistochemistry, immunofluorescence, ELISA, qRT-PCR, and Western blot. The reactive oxygen species (ROS) level was assessed using a fluorescence microplate and fluorescence microscope. Hydrogen peroxide (H2O2), malonaldehyde (MDA), and glutathione (GSH) were evaluated to determine oxidative stress. Lactic dehydrogenase (LDH) activity was examined to detect cell injury. Adhesion of CaOx monohydrate (COM) crystals to HK-2 cells was detected by crystal adhesion assay. HK-2 cell death or renal macrophage polarization was assessed by flow cytometry. In vivo, renal crystal deposition, tubular injury, crystal adhesion, cell apoptosis, oxidative stress, and inflammatory response were significantly increased in the 7-day glyoxylic acid- (Gly-) treated group but were decreased in the ROSI-treated groups, especially in the groups pretreated with ROSI. Moreover, ROSI significantly reduced renal Mp aggregation and M1Mp polarization but significantly enhanced renal M2Mp polarization. In vitro, ROSI significantly suppressed renal injury, apoptosis, and crystal adhesion of HK-2 cells and markedly shifted COM-stimulated M1Mps to M2Mps, presenting an anti-inflammatory effect. Furthermore, ROSI significantly suppressed oxidative stress by promoting the Nrf2/HO-1 pathway in HK-2 cells. These findings indicate that ROSI could ameliorate renal tubular injury that resulted from oxidative stress and inflammatory response by suppressing M1Mp polarization and promoting M2Mp polarization. Therefore, ROSI is a potential therapeutic and preventive drug for CaOx nephrolithiasis.

12.
Ann Palliat Med ; 10(8): 8701-8708, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34488359

RESUMO

BACKGROUND: There is a lack of data on drug-related problems (DRPs) occurring in nephrology department in China. The objective of this study was to identify and categorize the types and causes of DRPs and to assess their severity. DRPs were examined by clinical pharmacists and the results of their interventions were rated. METHODS: Clinical pharmacists reviewed all medication orders for patients and documented clinical pharmacy services within a nine-month study period. The Pharmaceutical Care Network Europe (PCNE) classification (Version 9.00) was used to identify DRPs. Our Primary outcomes measured the number, causes, types, potential hazards of DRPs and the types and success rate of intervention. RESULTS: Admission medication reconciliation data of 113 patients with chronic kidney disease (CKD) were collected and all of the medications were reviewed retrospectively. Exclude 26 patients who did not occurred DRPs, 87 patients (77%) identified 101 DRPs. The average DRP number per patient was 1.16. The most common type of problem was "treatment effectiveness P1" (84.16%; 85/101). The most common causes were "drug selection C1" (36.00%; 45/125), "dose selection C3" (29.60%; 37/125), and "patient related C7" (26.40%; 33/125). Clinical pharmacists totally proposed 249 interventions, of which 190 (76.31%) were fully accepted and implemented. CONCLUSIONS: DRPs are common among CKD patients in the nephrology department. Hence the necessity for pharmaceutical care to be improved to ensure the ongoing safety of patients.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Nefrologia , Preparações Farmacêuticas , Humanos , Farmacêuticos , Estudos Retrospectivos , Centros de Atenção Terciária
13.
Nucleic Acids Res ; 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34500460

RESUMO

MicroRNAs (miRNAs), which play critical roles in gene regulatory networks, have emerged as promising diagnostic and prognostic biomarkers for human cancer. In particular, circulating miRNAs that are secreted into circulation exist in remarkably stable forms, and have enormous potential to be leveraged as non-invasive biomarkers for early cancer detection. Novel and user-friendly tools are desperately needed to facilitate data mining of the vast amount of miRNA expression data from The Cancer Genome Atlas (TCGA) and large-scale circulating miRNA profiling studies. To fill this void, we developed CancerMIRNome, a comprehensive database for the interactive analysis and visualization of miRNA expression profiles based on 10 554 samples from 33 TCGA projects and 28 633 samples from 40 public circulating miRNome datasets. A series of cutting-edge bioinformatics tools and machine learning algorithms have been packaged in CancerMIRNome, allowing for the pan-cancer analysis of a miRNA of interest across multiple cancer types and the comprehensive analysis of miRNome profiles to identify dysregulated miRNAs and develop diagnostic or prognostic signatures. The data analysis and visualization modules will greatly facilitate the exploit of the valuable resources and promote translational application of miRNA biomarkers in cancer. The CancerMIRNome database is publicly available at http://bioinfo.jialab-ucr.org/CancerMIRNome.

14.
Front Plant Sci ; 12: 700159, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34276751

RESUMO

To understand the effects of source-sink relationships on rice yield response to elevated CO2 levels (eCO2), we conducted a field study using a popular japonica cultivar grown in a free-air CO2 enrichment environment in 2017-2018. The source-sink ratio of rice was set artificially via source-sink treatments (SSTs) at the heading stage. Five SSTs were performed in 2017 (EXP1): cutting off the flag leaf (LC1) and the top three functional leaves (LC3), removing one branch in every three branches of a panicle (SR1/3) and one branch in every two branches of a panicle (SR1/2), and the control (CK) without any leaf cutting or spikelet removal. The eCO2 significantly increased grain yield by 15.7% on average over all treatments; it significantly increased grain yield of CK, LC1, LC3, SR1/3, and SR1/2 crops by 13.9, 18.1, 25.3, 12.0, and 10.9%, respectively. The yield response to eCO2 was associated with a significant increase of panicle number and fully-filled grain percentage (FGP), and the response of crops under different SSTs was significantly positively correlated with FGP and the average grain weight of the seeds. Two SSTs (CK and LC3) were performed in 2018 (EXP2), which confirmed that the yield response of LC3 crops (25.1%) to eCO2 was significantly higher than that of CK (15.9%). Among the different grain positions, yield response to eCO2 of grains attached to the lower secondary rachis was greater than that of grains attached to the upper primary rachis. Reducing the source-sink ratio via leaf-cutting enhanced the net photosynthetic rate response of the remaining leaves to eCO2 and increased the grain filling ability. Conversely, spikelet removal increased the non-structural carbohydrate (NSC) content of the stem, causing feedback inhibition and photosynthetic down-regulation. This study suggests that reducing the source-sink ratio by adopting appropriate management measures can increase the response of rice to eCO2.

15.
J Clin Nurs ; 30(17-18): 2696-2707, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34196060

RESUMO

AIMS AND OBJECTIVES: To assist future offsite planning for pandemics, we documented lived experiences of cooperation among healthcare workers (HCWs) during the coronavirus disease (COVID-19) pandemic. BACKGROUND: The COVID-19 pandemic poses a global health crisis. Most recent studies on the COVID-19 focus on frontline HCWs' physio-psychological experiences, with few studies examining their experiences of cooperation. DESIGN: A descriptive phenomenological design reported based on COREQ checklist. METHODS: 25 HCWs (17 nurses and eight physicians) were interviewed, selected through convenience and purposive sampling, who participated in a medical aid mission in China during the COVID-19 pandemic. Data were collected via semi-structured online video interviews, and the transcripts were analysed using Colaizzi's phenomenological method. RESULTS: The HCWs experienced stressed and anxious, but rated their overall cooperation experience as positive. We categorised the reported experiences in five themes: (1) a multi-level management structure; (2) nurse managers as internal and external team coordinators; (3) high morale and a mutual supportive context; (4) a continuous streamlined workflow; and (5) the value of multidisciplinary collaboration in care. Reasonable management structure and division of work were the basis for successful aid mission. High morale and a mutual supportive context were foundational for growth and stress mitigation. The HCWs continuously streamlined workflow through communication and met patients' individual need through multidisciplinary collaboration. CONCLUSIONS: Planning for a pandemic aid mission is challenging, given the unpredictable nature of the working circumstances. Our results underline the importance of supportive strategies for COVID-19 aid mission. RELEVANCE TO CLINICAL PRACTICE: Recommendations for future pandemic planning: (1) positive morale and supportive working text should be paid prioritised attention; (2) sufficient experienced and ancillary staff should be recruited; (3) multiple communication channels such as regular handover meetings, online chat applications and electronic recording devices are essential, and (4) multidisciplinary cooperation are is necessary in COVID-19 wards.


Assuntos
COVID-19 , Pandemias , China , Pessoal de Saúde , Humanos , SARS-CoV-2
16.
J Phys Chem Lett ; 12(29): 6961-6966, 2021 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-34283605

RESUMO

The halide perovskite X-ray detector can meet the urgent needs of low-dose medical imaging by X-rays. However, there is still a pressing challenge in lacking robust methods for large-scale fabrication of high-quality perovskite films with tunable thickness. Here we report a laminated fabrication of polycrystalline MAPbI3 by using solvent-free liquid perovskite molten-salt (PMS), that offers reduced toxic issue, scalable fabrication, and highly tunability in film thickness. Nylon membrane was chosen as a scaffold for the infiltration of PMS, which simultaneously acts as a physical barrier to suppress the ionic migration in the MAPbI3-nylon composite (denoted as MAPbI3-LLP). The enhanced material properties result in good stability and high performance of X-ray detectors that show low detection limit and high sensitivity. Additionally, single gamma-ray photon detection was realized by MAPbI3-LLP detectors. The promising performance characteristics of such polycrystalline detectors can accelerate the adoption of polycrystalline perovskites in X-ray imaging and gamma-ray detection.

17.
Int Immunopharmacol ; 99: 107899, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34217993

RESUMO

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most prevalent and highly malignant pathological type of kidney cancer. Finding more precise biomarkers is critical for enhancing the prognosis of patients with ccRCC. Multiple studies have suggested that Holliday junction recognition protein (HJURP) promotes tumor progression and predicts poor prognosis in a variety of cancers. However, the role of HJURP in ccRCC remains unclear. METHODS: The ccRCC dataset was obtained from The Cancer Genome Atlas (TCGA), and the relationship between HJURP expression and ccRCC clinical features was investigated using R software. The effect of HJURP expression on survival was assessed using survival probabilities and Cox regression. Gene set enrichment analysis (GSEA) was used to identify HJURP-related signaling pathways in ccRCC. Finally, Tumor IMmune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA)were used to analyzethe correlation between HJURP expression and immunocyte infiltrates in ccRCC. RESULTS: HJURP expression was upregulated in ccRCC. Increased HJURP expression was associated with poor pathological features and correlated with poor prognosis in patients with ccRCC. Cox regression further found that HJURP expression was a high-risk factor for ccRCC patients. GSEA revealed that HJURP was closely linked to multiple immune-related signaling pathways. In ccRCC, HJURP expression was closely correlated with infiltration of various immune cells and expression of a wide range of immunocyte gene markers. CONCLUSION: HJURP is a potential independent prognostic marker in ccRCC that plays an essential role in the tumor microenvironment by regulating immunocyte infiltration.

18.
Environ Int ; 156: 106707, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34182192

RESUMO

The associations of long-term exposure to various constituents of fine particulate matter (≤2.5 µm in aerodynamic diameter, PM2.5) air pollution with lung function were not clearly elucidated in developing countries. The aim was to evaluate the associations of long-term exposure to main constituents of PM2.5 with lung function in China. This is a nationwide, cross-sectional analysis among 50,991 study participants from the China Pulmonary Health study. Multivariable linear regression models were used to obtain differences of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF), and forced expiratory flow at 25-75% of exhaled FVC (FEF25-75%) associated with an interquartile range (IQR) change of PM2.5 or its constituents. Residential annual PM2.5 levels varied from 26 µg/m3 to 92 µg/m3 (average: 53 µg/m3). An IQR increase of PM2.5 concentrations was associated with lower FEV1 (19.82 mL, 95% CI: 11.30-28.33), FVC (17.45 mL, 95% CI: 7.16-27.74), PEF (86.64 mL/s, 95% CI: 59.77-113.52), and FEF25-75% (31.93 mL/s, 95% CI: 16.64-47.22). Black carbon, organic matter, ammonium, sulfate, and nitrate were negatively associated with most lung function indicators, with organic matter and nitrate showing consistently larger magnitude of associations than PM2.5 mass. This large-scale study provides first-hand epidemiological evidence that long-term exposure to ambient PM2.5 and some constituents, especially organic matter and nitrate, were associated with lower large- and small- airway function.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/efeitos adversos , Poluição do Ar/análise , China , Estudos Transversais , Exposição Ambiental/efeitos adversos , Exposição Ambiental/análise , Volume Expiratório Forçado , Humanos , Pulmão , Material Particulado/análise
19.
Nat Commun ; 12(1): 3632, 2021 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-34131138

RESUMO

Multitudinous topological configurations spawn oases of many physical properties and phenomena in condensed-matter physics. Nano-sized ferroelectric bubble domains with various polar topologies (e.g., vortices, skyrmions) achieved in ferroelectric films present great potential for valuable physical properties. However, experimentally manipulating bubble domains has remained elusive especially in the bulk form. Here, in any bulk material, we achieve self-confined bubble domains with multiple polar topologies in bulk Bi0.5Na0.5TiO3 ferroelectrics, especially skyrmions, as validated by direct Z-contrast imaging. This phenomenon is driven by the interplay of bulk, elastic and electrostatic energies of coexisting modulated phases with strong and weak spontaneous polarizations. We demonstrate reversable and tip-voltage magnitude/time-dependent donut-like domain morphology evolution towards continuously and reversibly modulated high-density nonvolatile ferroelectric memories.

20.
ACS Appl Mater Interfaces ; 13(24): 28472-28483, 2021 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-34105933

RESUMO

Due to the presence of pores and low density, a high recoverable energy density (Wrec) value is usually obtained at the cost of energy storage efficiency (η) in lead-free potassium sodium niobate [(K, Na)NbO3, KNN] based ceramics, which also affects the hardness of ceramics, finally limiting the further development of practical applications. A high Wrec (∼3.60 J/cm3 ) and a high η (∼74.2%) are obtained in 0.975K0.5Na0.5NbO3-0.025LaBiO3 (0.975KNN-0.025LB) ceramics simultaneously under a high dielectric breakdown strength (DBS) of 340 kV/cm, together with a fast discharge rate (t0.9 ∼ 46 ns) and high power density (PD ∼ 49.4 MW/cm3). Further analysis of the intrinsic electronic structure is carried out via the first-principles calculation based on the density functional theory (DFT). An ultrahigh hardness (H) of 6.63 GPa can be accordingly obtained. This work combines excellent energy storage properties and ultrahigh hardness, which provides significant guidelines for applications in pulsed-power systems.

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