Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 55
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Eur J Radiol ; 119: 108652, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31521879

RESUMO

PURPOSE: To evaluate the clinical value of ultralow-dose CT (ULDCT) with adaptive statistical iterative reconstruction-V (ASiR-V) in the detection of pulmonary nodules in a Chinese population. METHOD: One hundred eighty-eight patients (16.41 ≤ BMI ≤ 29.87 kg/m2) with pulmonary nodules detected on low-dose chest CT (LDCT) underwent local ULDCT at the center of the chosen nodule with a scan length of 3 cm. LDCT was performed using the Assist kV (120/100 kV)/Smart mA mode and at 120 kV/2.8 mAs for ULDCT. After scanning, CT images were reconstructed with ASiR-V 50%. For both scans, nodule diameters were measured and reference standards were established for the presence and types of lung nodules found on LDCT. The sensitivity of ULDCT was compared against the standard, and logistic regression analysis was used to determine the independent predictors for nodule detection. RESULTS: Compared with LDCT (0.93 ±â€¯0.32 mSv), a 89.7% dose decrease was seen with ULDCT, for which the calculated effective dose was 0.096 ±â€¯0.006 mSv (P < 0.001). LDCT showed 188 nodules, including 123 solid and 65 subsolid nodules. The overall sensitivity for nodule detection in ULDCT was 90.4% (170/188), and 98.2% (54/55) for nodules ≥ 6 mm. In multivariate analysis, nodule types and diameters were independent predictors of sensitivity (P < 0.05). However, patients' BMI had no effect on nodule detection (P > 0.05). CONCLUSIONS: ULDCT can be used in the management of pulmonary nodules for people with BMI ≤ 30 kg/m2 at 10% radiation dose of LDCT.

2.
Biosci Biotechnol Biochem ; 83(11): 1992-1999, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31362597

RESUMO

The present study focused on the effect of paeonol, one of the main components of Guizhi Fuling Pill, on blood pressure, cerebral blood flow, and vascular endothelium injury in spontaneously hypertensive rats to provide theoretical basis for the treatment of hypertension. After treatment with paeonol, the mean arterial pressure (MAP) of LSHRT and HSHRT rats decreased gradually with the prolongation of treatment time. The systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd) and mean blood flow velocity (Vm) were significantly increased after paeonol treatment (p < 0.05). Paeonol effectively improved the blood pressure and increased the cerebral blood flow velocity in spontaneously hypertensive rats. This may be related to the fact that paeonol reduced the blood viscosity and the oxidative stress and improved the antioxidant capacity. Moreover, paeonol protected vascular endothelial cells and reduced vascular endothelial injury in spontaneously hypertensive rats.

3.
Chemosphere ; 236: 124383, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31344616

RESUMO

The volatility of atmospheric aerosols greatly influences the gas-particle partitioning, chemical mechanisms and lifetime of aerosols. Due to the complex composition, the volatility of organic aerosol is one of the major sources of uncertainty in measuring and modeling ambient aerosols. Despite high aerosol loading in the atmosphere in China, especially in winter, few field measurements were conducted targeting the volatility of ambient organic aerosol (OA). With the deployment of a thermodenuder-aerosol mass spectrometer (TD-AMS) system, the volatility of non-refractory submicron aerosols (NR-PM1) were measured on an island near the coastal line for the regional air in wintertime in southern China. NO3- and Cl- showed the highest volatility in the NR-PM1 chemical species, while SO42- showed the least volatility. Organic aerosol showed a moderate volatility, evaporating at a stable rate (0.57% °C-1) at temperatures lower than 150 °C and keeping a stable volatility when its loading increases, which could be an advantage for parameterization of OA in air quality models. Based on both positive matrix factorization and chemical mass balance modeling of OA composition, biomass burning OA was found to be the most volatile factor, followed by hydrocarbon-like OA and more-oxidized oxygenated OA. By summarizing the OA volatility measured in this study and in the literature, we found that the volatilities of different OA factors at different locations do not have a clear relationship with the OA oxidation state, possibly due to the vague understanding of local OA aging mechanisms and mixing states.

4.
BMC Cardiovasc Disord ; 19(1): 115, 2019 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-31096919

RESUMO

BACKGROUND: Previous studies reported that low level of oestradiol (E2) was associated with higher risk of cardiovascular disease (CVD). However, little study examined the relationship between E2 and CVD in longevous women, which were deficient in serum E2 for the post-menopausal status. Therefore, this study aims to explore the association between E2 and CVD risk factors in a group of female centenarians of Hainan, China. METHODS: A total of 413 female centenarians (aged from 100 to 115) from China Hainan Centenarian Cohort Study (CHCCS) were enrolled in this study. Home interviews were conducted to collected data on demographic characteristics, health-related lifestyles, and anthropometrics. The level of serum E2 was assessed in the Clinical Laboratory of Hainan branch of PLA General Hospital. The variables of CVD risk factors, including blood pressures, lipids and blood glucose, were measured through standard procedures. RESULTS: Significant negative correlations between levels of serum E2 and TC, HDL-C, and LDL-C were observed in this study. Compared with the highest group of E2, the odds ratio and 95% confidence intervals of high LDL-C in groups 3, 2 and 1 were OR1.94 (CI0.82-4.62), OR3.61 (CI1.27-10.25) and OR9.29 (CI2.08-41.53), respectively. Similarly, the prevalence of hypertension was decreased with the increase of serum E2. The odds ratio and 95% confidence intervals of stage-2 hypertension in groups 3, 2 and 1 versus highest E2 group were OR1.34 (CI0.49-3.72), OR1.36 (CI0.47-3.99) and OR1.38 (CI0.45-4.20), respectively. CONCLUSIONS: This study examined the relationship between E2 and CVD risk factors in a group of community-based female centenarians. A negative correlations between serum E2 levels and CVD risk factors, i.e. high level of LDL-C, TC, and hypertension were observed in this population. Besides, the level of serum E2 is also negatively correlated with HDL-C. Further studies on the correlation between serum E2 and CVD risk factors, especially dyslipidemia, in longevous and post-menopausal women are warranted.

5.
Front Biosci (Landmark Ed) ; 24: 1363-1376, 2019 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31136984

RESUMO

Rho GTPase-activating proteins (RhoGAPs) are implicated in the development and progression of hepatocellular carcinoma (HCC). We tested the idea that RICH2 is a tumor suppressor in HCC. Consistent with this, RICH2 was downregulated in HCC and HCC cell lines and RICH2 expression negatively correlated with the tumor size, TNM stage and metastasis in HCC. RICH2, in a Cdc42 dependent manner, regulated the formation of filopodia in HCC and stable overexpression of RICH2 significantly inhibited the clone formation, proliferation and invasion of HCC cells in vitro. Gene set enrichment analysis (GSEA) showed that the expression of RICH 2 positively correlated with the expression of WNT5a, that exert antagonistic effect on canonical WNT signalling whereas RICH2 expression inversely correlated with the expression of ß-catenin (CTNNB1), that is involved in the proliferation and invasion HCC. These findings concurred with co-immunoprecipation of RICH2 with endogenous Cdc42, Rac1, and ß-catenin. Finally, RICH2 overexpression suppressed tumor growth in vivo. The findings support the idea that RICH2 might act as a tumor suppressor in HCC.

6.
Nat Commun ; 10(1): 1594, 2019 04 08.
Artigo em Inglês | MEDLINE | ID: mdl-30962429

RESUMO

The efficient construction of enantiomerically enriched molecules from simple starting materials via catalytic asymmetric synthesis strategies is a key challenge in synthetic chemistry. Metallated azomethine ylides are commonly-used synthons for the preparation of N-heterocycles and α-amino acids. Remarkably, to date, the utilization of azomethine ylides for the facile access to chiral amines has proven elusive. Here, we report that a synergistic Cu/Ir-catalytic system combined with careful tuning of the steric congestion can be used to convert aldimine esters to a variety of chiral homoallylic amines via a cascade allylation/2-aza-Cope rearrangement. The elucidation of the distinct effects of each stereogenic center of the allylation intermediates on the stereochemical outcome and chirality transfer in the rearrangement further guided the selection of catalysts combination.

8.
Phys Chem Chem Phys ; 21(16): 8508-8516, 2019 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-30957807

RESUMO

The adsorption separation of C6-C8 hydrocarbons in metal-organic frameworks (MOFs) has attracted extensive attention worldwide due to its technical feasibility and high energy efficiency in the petroleum industry. In this study, a large-scale computational screening of 13 512 MOFs with topological diversity was carried out to search optimal candidates for the simultaneous separation of two dimethyl butanes (DMB) from the quinary equimolar mixture of hexane isomers. We first screened out 841 MOFs according to their geometrical properties such as pore limited diameter (PLD) and volumetric surface area. Subsequently, high-performing MOFs were ranked out by an evaluation metric of adsorption performance score (APS), that is the product of the adsorption capacity of DMB and the selectivity of DMB over normal and mono-branched hexane isomers (N + M), on the basis of the predicted capacities by the grand canonical Monte Carlo (GCMC) simulations at 10 bar and 433 K. The structure-property relationships were established between APS and MOF descriptors such as density, PLD, etc. Among the screened 841 MOFs, the MOF with highest APS was MOF-163 because it provided an ideal pore topology with the 6.85 Å annular channel to distinguish DMB from the N + M isomers. The breakthrough predictions further demonstrated that the dimensionless residence time of 2,2-dimethylbutane (22DMB) was significantly different from that of n-hexane; this indicated that MOF-163 was a superior candidate for the dynamic separation of hexane isomers. Radial distribution function, adsorption equilibrium configurations and mass center probability density distributions were investigated to elucidate why MOF-163 could differentiate DBM from the N + M isomers. The molecular-level insights proposed in this study will facilitate the development of new MOFs for the separation of hydrocarbons in the petroleum industry.

9.
Molecules ; 24(7)2019 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-30959775

RESUMO

The physicochemical properties of four 1-alkyl-3-methylimidazolium bromide ([CnC1im]Br, n = 5, 6, 7, 8) ionic liquids (ILs) were investigated in this work by using inverse gas chromatography (IGC) from 303.15 K to 343.15 K. Twenty-eight organic solvents were used to obtain the physicochemical properties between each IL and solvent via the IGC method, including the specific retention volume and the Flory⁻Huggins interaction parameter. The Hildebrand solubility parameters of the four [CnC1im]Br ILs were determined by linear extrapolation to be δ 2 ( [ C 5 C 1 im ] Br ) = 25.78 (J·cm-3)0.5, δ 2 ( [ C 6 C 1 im ] Br ) = 25.38 (J·cm-3)0.5, δ 2 ( [ C 7 C 1 im ] Br ) =24.78 (J·cm-3)0.5 and δ 2 ( [ C 8 C 1 im ] Br ) = 24.23 (J·cm-3)0.5 at room temperature (298.15 K). At the same time, the Hansen solubility parameters of the four [CnC1im]Br ILs were simulated by using the Hansen Solubility Parameter in Practice (HSPiP) at room temperature (298.15 K). The results were as follows: δ t ( [ C 5 C 1 im ] Br ) = 25.86 (J·cm-3)0.5, δ t ( [ C 6 C 1 im ] Br ) = 25.39 (J·cm-3)0.5, δ t ( [ C 7 C 1 im ] Br ) = 24.81 (J·cm-3)0.5 and δ t ( [ C 8 C 1 im ] Br ) = 24.33 (J·cm-3)0.5. These values were slightly higher than those obtained by the IGC method, but they only exhibited small errors, covering a range of 0.01 to 0.1 (J·cm-3)0.5. In addition, the miscibility between the IL and the probe was evaluated by IGC, and it exhibited a basic agreement with the HSPiP. This study confirms that the combination of the two methods can accurately calculate solubility parameters and select solvents.


Assuntos
Imidazóis/química , Líquidos Iônicos/química , Solubilidade , Brometos/química , Cromatografia Gasosa , Solventes/química
10.
Int J Mol Med ; 43(4): 1900-1910, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30816438

RESUMO

To study the effect and molecular mechanisms of amlodipine besylate combined with acupoint application of traditional Chinese medicine nursing on the treatment methods of renal failure and hypertension. A total of 60 cases of renal failure hypertension were randomly divided into the Control group and the Treatment group. The control group was treated with amlodipine besylate, while the treatment group was treated with amlodipine besylate combined with acupoint application of traditional Chinese medicine nursing. A rat model of renal failure hypertension was established. Rats were divided into the sham group, model group, NC group (treated with amlodipine besylate) and treatment group (treated with amlodipine besylate combined with acupoint application of traditional Chinese medicine nursing). Rats were given drugs at 10­20 weeks of age to observe their general condition and detect changes of blood pressure, blood biochemical indices and urine index. The pathological changes of renal tissue were examined by hematoxylin and eosin staining, and the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)9 were detected by immunohistochemistry. Reverse transcription­quantitative polymerase chain reaction was used to determine mRNA expression of phosphoinositide 3­kinase (PI3K), protein kinase B (AKT) and endothelin (ET)­1 and western blotting was used to detect the expression of phosphorylated (p)­PI3K/PI3K, p­AKT/AKT and p­nuclear factor (NF)­κB p65/NF­κB p65 protein. Systolic and diastolic blood pressures in Treated group patients were significantly lower compared with in Control group patients. The systolic and diastolic blood pressure of rats were significantly decreased and blood urea nitrogen (BUN), carbapenem­resistant Enterobacteriaceae (CRE), N­acetyl­ß­D­glucosaminidase (NAG), urine protein (UP) and blood urea protein (BUP), contents were significantly decreased following amlodipine besylate treatment. The expression of VEGF and matrix metallopeptidase 9 protein were significantly decreased, but the expression of PI3K, AKT mRNA and p­PI3K/PI3K, p­AKT/AKT protein were significantly increased. ET­1 mRNA and p­NF­κB p65/NF­κB protein were significantly increased. The pathological alterations of renal tissue were improved and the pathological changes of glomerulus, tubule and interstitium were alleviated. Amlodipine besylate combined with acupoint application of traditional Chinese medicine nursing can effectively reduce the systolic pressure and diastolic pressure of patients, and improve the symptoms and signs of patients, which may be associated with the regulation of the expression of PI3K/AKT pathway, so as to regulate the expression of BUN, CRE, UP, BUP and NAG.


Assuntos
Pontos de Acupuntura , Anlodipino/uso terapêutico , Hipertensão/complicações , Hipertensão/tratamento farmacológico , Medicina Tradicional Chinesa , Insuficiência Renal/complicações , Insuficiência Renal/tratamento farmacológico , Transdução de Sinais , Anlodipino/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Feminino , Humanos , Hipertensão/sangue , Hipertensão/fisiopatologia , Rim/efeitos dos fármacos , Rim/patologia , Masculino , Metaloproteinase 9 da Matriz/metabolismo , Pessoa de Meia-Idade , Fosfatidilinositol 3-Quinases/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Ratos Endogâmicos SHR , Insuficiência Renal/sangue , Insuficiência Renal/fisiopatologia , Transdução de Sinais/efeitos dos fármacos , Resultado do Tratamento , Fator A de Crescimento do Endotélio Vascular/metabolismo
11.
Am J Med Sci ; 356(5): 481-486, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30384955

RESUMO

Exosomes are small secretory vesicles that are involved in intercellular communication. Exosomes are secreted by many types of cells and exert important functions in plasma-membrane exchange as well as the transport of bioactive substances, such as proteins, messenger ribonucleic acids (mRNAs), micro ribonucleic acids (miRNAs) and organelles. Exosomes may regulate physiological processes by altering gene regulatory networks or epigenetic recombination. Recent studies have shown that exosomes secreted by stem cells can effectively transport proteins, mRNAs and miRNAs and play important roles in the regulation of tissue regeneration. This report reviews current progress in exosome studies as well as their emerging roles in stem cell research and potential clinical use.

12.
Clin Interv Aging ; 13: 2045-2053, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30410320

RESUMO

Background: Functional dependence (FD) and vitamin D deficiency are common conditions in older adults. However, little is known about the relationship between FD and serum vitamin D status in centenarians. The current study was designed to evaluate the prevalence of FD and examine its relationship with serum vitamin D status among centenarians in China. Subjects and methods: A cross-sectional study of a large sample of Chinese centenarians including 180 men and 822 women was conducted from June 2014 to December 2016. Home interviews, physical examinations, and blood analyses were performed in 958 centenarians following standard procedures. FD was evaluated using the Barthel index of activities of daily living (ADL). Serum 25-hydroxyvitamin D (25OHD) concentrations were measured as a marker of vitamin D status. Results: The prevalence of centenarians with FD was 71.2%. Vitamin D deficiency, lack of tea consumption, lack of outdoor activities, visual impairment, and fracture were predictors of FD. Centenarians in the lowest quartile of serum 25OHD concentration had an approximately threefold greater likelihood of FD than those in the highest quartile in multiple logistic regression models (OR =2.88; 95% CI 1.75-4.73; P<0.001). The multivariable OR with a 1 ng/mL decrease in serum 25OHD concentration was 1.06 (95% CI 1.04-1.08; P<0.001) for FD. Conclusion: Serum 25OHD levels have important associations with FD in Chinese centenarians. Future research could focus on the value of intervening in the case of low serum 25OHD levels through vitamin D supplementation and improving ADL in the older population.

13.
Clin Rheumatol ; 37(11): 3069-3076, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30293124

RESUMO

To evaluate the utility of mono-exponential and bi-exponential model-based diffusion-weighted MR imaging and IDEAL-IQ sequence for differentiating the activity of sacroiliitis in ankylosing spondylitis (AS). AS patients were divided into active group (n = 30) and inactive group (n = 28) according to Ankylosing Spondylitis Disease Activity Score (ASDAS) with C-reactive protein (CRP). In addition, 30 healthy volunteers were chosen as healthy group. Subjects were scanned by conventional MRI, diffusion-weighted imaging, and IDEAL-IQ sequence. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), and fat fraction (FF) values were measured, and their relative values (rADC, rD, rD*, rf) were calculated by the formula ADC (D,D*,f)lesion/ADC (D,D*,f)reference, respectively. The ADC, D, rADC, and rD of active group were the highest among the three groups, followed by inactive and healthy group. However, D* and rD* showed no significant difference among the three groups. FF was significantly higher in inactive group than in healthy and active group. ADC and D had significantly higher AUCs than f for differentiating active group from healthy group, while FF had the highest AUC for distinguishing inactive sacroiliitis from healthy group. DWI and IDEAL-IQ imaging are helpful in quantitatively assessing the activity of sacroiliitis in AS patients.

14.
Zhongguo Zhong Yao Za Zhi ; 43(14): 2935-2943, 2018 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-30111052

RESUMO

Polygonatum is a genus of the perennial herb family Liliaceae, with great potential in food, medicine and other field. In this study, genetic diversity and cluster structure analysis of 6 species in Polygonatum were investigated the molecular marker technique of simple sequence repeat (SSR). A total of 49 SSR makers were used to study genetic diversity and population structure within 60 germplasm resources which obtained from 38 counties and cities in 14 provinces of China. A total of 211 alleles were identified and the number of alleles ranged from 2 to 10, with an average of 4.306 1 alleles per SSR. The range of polymorphism information content (PIC) varied from 0.731 8 to 0.031 7, with the average of 0.309 6. The cluster analysis classified 60 germplasm resources into four defined groups at the genetic distance value of 0.26, among which most species with relatives were clustered into the same group. Extraordinarily, there were 6 germplasm resources clustered into other species, indicating that the classification of inter-genus and geographical distribution was crossed in Polygonatum. The genetic diversity index of the 4 geographical populations from high to low was: Western region, Central China, Southern China, Eastern China. The population structure analysis, also indicating divided the entire collection into four groups, which was similar to the assignment pattern of cluster structure analysis. These results suggested that the Polygonatum germplasm resources used in this study is rich in relatively high genetic diversity with large variation range, relatively fuzzy boundaries of species. It appeared the phenomenon that there is a difference decreases between the alternate leaf system and the rotation leaf system. The genetic diversity in the western region was higher than that in other regions, and the western region may be the origin center of the genus Polygonatum.

15.
BMC Geriatr ; 18(1): 198, 2018 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-30157761

RESUMO

BACKGROUND: Hypovitaminosis D and depressive syndromes are common conditions in old adults. However, little is known about the relationship between vitamin D and depression in exceptional aged people. The objective of this study is to evaluate the relationship between vitamin D levels and depressive symptoms in Chinese longevous persons. METHODS: We used a dataset from a cross-sectional survey of a sample of Chinese longevous people with self-reported age 100 or older, including 175 men and 765 women, was conducted from June 2014 to December 2016 in Hainan Province, China. Data on demographics, lifestyle characteristics and health conditions were collected using a structured questionnaire. Anthropometrics and blood samples were obtained following the standard procedure. Depressive symptoms of the participants were assessed using a shortened version of the Geriatric Depression Scale (GDS-15). Serum vitamin D levels were measured using an automated radioimmunoassay. RESULTS: The prevalence of longevous persons with depressive symptoms among the sample was 32.2% (95% confidence interval: 29.7-34.7%). Serum vitamin D levels were lower in participants with depressive symptoms than in those without (20.8 ± 8.7 vs. 23.7 ± 9.7, ng/mL). Vitamin D deficiency was an independent risk factor for depression after controlling for the potential covariates (Odds ratio = 1.47, 95% Confidence interval = 1.08-2.00; p = 0.014). A negative relationship between serum vitamin D levels and depressive symptoms was also detected, and the relationship remained significant after adjusting for a wide range of other covariates. The multivariate adjusted odds ratio of depressive symptoms for the lowest versus highest quartiles of vitamin D levels was 1.73 (95% confidence interval: 1.10-2.72), and the adjusted odds ratio with a 5 ng/mL decrement of serum 25OHD levels was 1.10 (95% confidence interval: 1.01-1.19). CONCLUSIONS: This study showed an inverse association between vitamin D levels and depressive symptoms among Chinese longevous persons. Depressive symptoms should be screened in longevous persons who had vitamin D deficiency. Further studies on vitamin D supplement and prevention along with treatment of depression are needed among very old population.

16.
BMC Cardiovasc Disord ; 18(1): 73, 2018 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-29716519

RESUMO

BACKGROUND: Centenarians refer to a special group who have outlived most of their fellows. Body shape and abdominal obesity have been identified as cardiovascular disease (CVD) risk factors. Our study aimed to evaluate the relationship between body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) and CVD risk factors among male and female centenarians in Hainan province. METHODS: Five hundred thirty-seven centenarians aged between 100 and 115 (Mage = 107 years old) years participated in this study. Each participant received a standardized questionnaire and physical examination. We measured anthropometric variables (BMI, WC, WHR, WHtR, SBP and DBP) and serum lipid (TC, TG, HDL-C and LDL-C). RESULTS: 76.9% (n = 413) of the study subjects were female. TC, TG, LDL-C and HDL-C were significantly higher in female group than that of male group. BMI, WC and WHtR were well-correlated with the CVD risk factors. The anthropometric measures were negatively related with HDL-C levels and positively related with the other CVD risk factors. CONCLUSIONS: Hainan centenarians were short in stature and underweight. Moreover, female centenarians were often pear-shaped, while male centenarians were often apple-shaped. Further, BMI, WC and WHtR were well-correlated with the serum lipid, and TC, TG, LDL-C and HDL-C were significantly higher in females than males. Also, BMI, WC and WHtR were closely related to the incidence of dyslipidemia in females, including high TG, high LDL-C and low HDL-C.

17.
Clin Interv Aging ; 13: 515-522, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29662307

RESUMO

Background: Thyroid nodules (TNs) are common thyroid lesions in older population. Few studies have focused on the prevalence of TNs and their relationship to lifestyle characteristics and dietary habits in centenarians. The current study aimed at determining the prevalence of TNs in Chinese centenarians by using high-resolution ultrasound (US) equipment and at investigating its relationship to lifestyle characteristics and dietary habits. Participants and methods: The current study was part of the China Hainan Centenarian Cohort Study that was conducted in Hainan, an iodine-sufficient region in People's Republic of China. A total of 874 permanent residents aged ≥100 years (mean age =102.8±2.8 years) without any missing data were included in the analysis. Results: Among the participants, 649 of them were detected at least one TN under the US examinations. The overall prevalence rate of TNs was 74.3%. The prevalence of TNs was higher in participants who were women, had hypertension, had diabetes, and were underweight compared with their counterparts. Multivariate logistic regression analyses showed that being female, hypertensive, and diabetic; betel quid consumption; and red meat consumption were independent risk factors, while being underweight and nut consumption were independent protective factors for TNs. Conclusion: Our findings indicate that the presence of TNs was highly prevalent in Chinese centenarians, particularly in women. In addition to gender, having hypertension, having diabetes, and being underweight, the presence of TNs was independently associated with betel quid, red meat, and nut consumption. Further prospective studies are warranted to verify these associations in populations from different age strata, races, cultures, and iodine supplementation.


Assuntos
Comportamento Alimentar , Estilo de Vida , Nódulo da Glândula Tireoide/epidemiologia , Idoso de 80 Anos ou mais , China , Comorbidade , Diabetes Mellitus Tipo 2/epidemiologia , Feminino , Humanos , Hipertensão/epidemiologia , Masculino , Obesidade/epidemiologia , Prevalência , Estudos Prospectivos , Fatores de Risco
19.
J Environ Sci (China) ; 63: 277-284, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29406110

RESUMO

Haze in China is primarily caused by high pollution of atmospheric fine particulates (PM2.5). However, the detailed source structures of PM2.5 light extinction have not been well established, especially for the roles of various organic aerosols, which makes haze management lack specified targets. This study obtained the mass concentrations of the chemical compositions and the light extinction coefficients of fine particles in the winter in Dongguan, Guangdong Province, using high time resolution aerosol observation instruments. We combined the positive matrix factor (PMF) analysis model of organic aerosols and the multiple linear regression method to establish a quantitative relationship model between the main chemical components, in particular the different sources of organic aerosols and the extinction coefficients of fine particles with a high goodness of fit (R2=0.953). The results show that the contribution rates of ammonium sulphate, ammonium nitrate, biomass burning organic aerosol (BBOA), secondary organic aerosol (SOA) and black carbon (BC) were 48.1%, 20.7%, 15.0%, 10.6%, and 5.6%, respectively. It can be seen that the contribution of the secondary aerosols is much higher than that of the primary aerosols (79.4% versus 20.6%) and are a major factor in the visibility decline. BBOA is found to have a high visibility destroying potential, with a high mass extinction coefficient, and was the largest contributor during some high pollution periods. A more detailed analysis indicates that the contribution of the enhanced absorption caused by BC mixing state was approximately 37.7% of the total particle absorption and should not be neglected.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/estatística & dados numéricos , Monitoramento Ambiental , Material Particulado/análise , Aerossóis/análise , Atmosfera/química , China
20.
BMC Med Genomics ; 11(1): 7, 2018 Feb 02.
Artigo em Inglês | MEDLINE | ID: mdl-29394898

RESUMO

BACKGROUND: Human aging is a hot topic in biology, and it has been associated with DNA methylation changes at specific genomic sites. We aimed to study the changes of DNA methylation at a single-CpG-site resolution using peripheral blood samples from centenarians. METHODS: Using Illumina 450 K Methylation BeadChip microarray assays, we carried out a pool-based, epigenome-wide investigation of DNA methylation of blood samples from 12 centenarians and 12 healthy controls. Differentially methylated cytosine-phosphate-guanosine (CpG) sites were selected for further pyrosequencing analysis of blood samples from 30 centenarians and 30 healthy controls. RESULT: We identified a total of 31 high-confidence CpG sites with differential methylation profiles between the groups: 9 (29%) were hypermethylated and 22 (71%) were hypomethylated in centenarians. It was also found that hypermethylation of HKR1 and hypomethylation of ROD1 and NLRC5 genes strongly correlated with age in centenarians. CONCLUSION: Our results indicate that the methylation profile combination of HKR1, ROD1, and NLRC5 could be a promising biomarker for aging in Hainan centenarians.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA