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1.
Zootaxa ; 4995(2): 303-333, 2021 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-34810569

RESUMO

Eighteen new species of the genus Meleonoma Meyrick are described: M. arcivalvata sp. nov., M. chongqingensis sp. nov., M. curvativa sp. nov., M. curvitaeniana sp. nov., M. dilatifasciata sp. nov., M. fasciptera sp. nov., M. globoidea sp. nov., M. graciliclavata sp. nov., M. grandivalvula sp. nov., M. lunata sp. nov., M. medispinea sp. nov., M. proapicalis sp. nov., M. raphidacantha sp. nov., M. sinuaclavata sp. nov., M. tenuiclavata sp. nov., M. tetrodonta sp. nov. M. ventridentata sp. nov. and M. ventrisinuata sp. nov. The female of M. similifloralis (Wang, 2006) is described for the first time. Images of both adults and genitalia are provided. All species are divided into two species-groups, the dentivalvata species-group and the fasciptera species-group. A key to each group and maps showing the distribution of each group in China are given.


Assuntos
Lepidópteros , Mariposas , Distribuição Animal , Animais , China , Feminino , Genitália
2.
Signal Transduct Target Ther ; 6(1): 300, 2021 08 11.
Artigo em Inglês | MEDLINE | ID: mdl-34381015

RESUMO

Elderly people and patients with comorbidities are at higher risk of COVID-19 infection, resulting in severe complications and high mortality. However, the underlying mechanisms are unclear. In this study, we investigate whether miRNAs in serum exosomes can exert antiviral functions and affect the response to COVID-19 in the elderly and people with diabetes. First, we identified four miRNAs (miR-7-5p, miR-24-3p, miR-145-5p and miR-223-3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups. We further demonstrated that these miRNAs, either in the exosome or in the free form, can directly inhibit S protein expression and SARS-CoV-2 replication. Serum exosomes from young people can inhibit SARS-CoV-2 replication and S protein expression, while the inhibitory effect is markedly decreased in the elderly and diabetic patients. Moreover, three out of the four circulating miRNAs are significantly increased in the serum of healthy volunteers after 8-weeks' continuous physical exercise. Serum exosomes isolated from these volunteers also showed stronger inhibitory effects on S protein expression and SARS-CoV-2 replication. Our study demonstrates for the first time that circulating exosomal miRNAs can directly inhibit SARS-CoV-2 replication and may provide a possible explanation for the difference in response to COVID-19 between young people and the elderly or people with comorbidities.


Assuntos
COVID-19/genética , Diabetes Mellitus/genética , MicroRNAs/genética , Glicoproteína da Espícula de Coronavírus/genética , Adulto , Fatores Etários , Idoso , COVID-19/sangue , COVID-19/patologia , COVID-19/virologia , China , MicroRNA Circulante/sangue , MicroRNA Circulante/genética , Estudos de Coortes , Diabetes Mellitus/sangue , Diabetes Mellitus/patologia , Diabetes Mellitus/virologia , Exercício Físico , Exossomos/genética , Exossomos/metabolismo , Exossomos/virologia , Feminino , Regulação da Expressão Gênica , Células HEK293 , Interações Hospedeiro-Patógeno/genética , Humanos , Masculino , MicroRNAs/sangue , Pessoa de Meia-Idade , SARS-CoV-2/genética , SARS-CoV-2/crescimento & desenvolvimento , SARS-CoV-2/metabolismo , Glicoproteína da Espícula de Coronavírus/sangue , Replicação Viral
3.
Sci Adv ; 7(7)2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33568480

RESUMO

Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molecular, neuronal, and behavioral levels. Sperm small RNAs, and microRNAs (miRNAs) in particular, exhibit distinct expression profiles in F0 males of depression-like model and recapitulate paternal depressive-like phenotypes in F1 offspring. Neutralization of the abnormal miRNAs in zygotes by antisense strands rescues the acquired depressive-like phenotypes in F1 offspring born to F0 males of depression-like model. Mechanistically, sperm miRNAs reshape early embryonic transcriptional profiles in the core neuronal circuits toward depression-like phenotypes. Overall, the findings reveal a causal role of sperm miRNAs in the inheritance of depression and provide insight into the mechanism underlying susceptibility to depression.

4.
Zootaxa ; 4881(2): zootaxa.4881.2.3, 2020 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-33311314

RESUMO

Twenty-one new species of the genus Meleonoma Meyrick are described: M. acutata sp. nov., M. annulignatha sp. nov., M. artivalva sp. nov., M. basiprocessa sp. nov., M. bicornea sp. nov., M. bidigitata sp. nov., M. circinans sp. nov., M. compacta sp. nov., M. cuneata sp. nov., M. forcipata sp. nov., M. ledongensis sp. nov., M. longihamata sp. nov., M. mecobursoides sp. nov., M. microdonta sp. nov., M. papillisetosa sp. nov., M. parallela sp. nov., M. recticostata sp. nov., M. segregnatha sp. nov., M. sinuicosta sp. nov., M. taiwanensis sp. nov. and M. taeniophylla sp. nov. The male of M. flavilineata Kitajima et Sakamaki, 2019 is described for the first time. Images of both adults and genitalia are provided. All species are divided into two species-groups, and a key to each group as well as a map showing the distribution of each group in China are given.


Assuntos
Lepidópteros , Mariposas , Distribuição Animal , Animais , China , Genitália
5.
Zookeys ; 975: 125-157, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33117068

RESUMO

Sixteen new species of the genus Meleonoma Meyrick, 1914 from Hainan Island, China are described: M. apicicurvata Wang, sp. nov., M. apicirectangula Wang, sp. nov., M. bicuspidata Wang, sp. nov., M. bidentata Wang, sp. nov., M. conica Wang, sp. nov., M. hainanensis Wang, sp. nov., M. latiunca Wang, sp. nov., M. linearis Wang, sp. nov., M. magnidentata Wang, sp. nov., M. ornithorrhyncha Wang, sp. nov., M. parilis Wang, sp. nov., M. pectinalis Wang, sp. nov., M. puncticulata Wang, sp. nov., M. quadritaeniata Wang, sp. nov., M. robustispina Wang, sp. nov. and M. rostellata Wang, sp. nov. Images of adult dorsal habitus and genitalia of the new species are provided. A map showing the collecting localities and photos of the habitat where the specimens were collected are provided, along with two maps showing the distribution of each species.

6.
Zootaxa ; 4838(3): zootaxa.4838.3.2, 2020 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-33056811

RESUMO

Fifteen new species of the genus Meleonoma Meyrick are described: M. anisodonta sp. nov., M. catenata sp. nov., M. dilativalva sp. nov., M. dorsibacilliformis sp. nov., M. lanceolata sp. nov., M. longaedeaga sp. nov., M. longiprocessa sp. nov., M. lunulata sp. nov., M. papillata sp. nov., M. parvissima sp. nov., M. rugulosa sp. nov., M. tenuiuncata sp. nov., M. tianmushana sp. nov., M. triacantha sp. nov. and M. ventrospinosa sp. nov.; one species, M. aridula (Meyrick, 1910), is newly recorded from China; and the female of M. microbyrsa (Wang, 2003) is described for the first time. Images of both adults and genitalia are provided. All species are divided into two species-groups, and a key to each group as well as a map showing the distribution of each group in China are given.


Assuntos
Mariposas , Distribuição Animal , Estruturas Animais , Animais , China , Feminino , Tamanho do Órgão
7.
Zootaxa ; 4763(3): zootaxa.4763.3.3, 2020 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-33056854

RESUMO

Meleonoma Meyrick, 1914 is treated as a genus of the family Autostichidae based on the recent study. Fifty species are transferred from the genus Cryptolechia to Meleonoma, and eight Meleonoma species groups are proposed for the taxonomic convenience based on both molecular data and morphological study. Eight species groups include: the malacobyrsa group, the segregnatha group, the annulignatha group, the fasciptera group, the jigongshanica group, the dentivalvata group, the facialis group, and the acutiuscula group. Diagnostic characters and representative illustrations of each species group are provided. A discussion on the proposed species groups is given, and a checklist of all the 88 described Meleonoma species is provided.


Assuntos
Mariposas , Distribuição Animal , Animais
8.
Neurosci Bull ; 33(6): 711-721, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29196874

RESUMO

Voltage-dependent anion channel 1 (VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2-5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4 (TLR4). Intrathecal injection of minocycline, an inhibitor of microglia, also attenuated the pain hypersensitivity of rat models of bone cancer pain. These results suggest that VDAC1 plays a significant role in the development of complicated cancer pain, possibly by regulating the expression of TLR4.


Assuntos
Neoplasias Ósseas/metabolismo , Dor do Câncer/metabolismo , Hiperalgesia/metabolismo , Microglia/metabolismo , Corno Dorsal da Medula Espinal/metabolismo , Receptor 4 Toll-Like/metabolismo , Canal de Ânion 1 Dependente de Voltagem/metabolismo , Animais , Dor do Câncer/tratamento farmacológico , Modelos Animais de Doenças , Feminino , Hiperalgesia/tratamento farmacológico , Vértebras Lombares , Microglia/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , Corno Dorsal da Medula Espinal/efeitos dos fármacos , Receptor 4 Toll-Like/efeitos dos fármacos , Regulação para Cima , Canal de Ânion 1 Dependente de Voltagem/antagonistas & inibidores
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