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1.
Schizophr Bull ; 46(2): 442-453, 2020 02 26.
Artigo em Inglês | MEDLINE | ID: mdl-31355879

RESUMO

A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.


Assuntos
Imagem de Tensor de Difusão/métodos , Rede Nervosa/patologia , Transtorno Obsessivo-Compulsivo/patologia , Esquizofrenia/patologia , Máquina de Vetores de Suporte , Substância Branca/patologia , Adolescente , Adulto , Comorbidade , Feminino , Humanos , Masculino , Rede Nervosa/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/epidemiologia , Esquizofrenia/diagnóstico por imagem , Esquizofrenia/epidemiologia , Substância Branca/diagnóstico por imagem , Adulto Jovem
2.
Schizophr Bull ; 45(1): 199-210, 2019 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-29365198

RESUMO

Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.


Assuntos
Encéfalo/fisiopatologia , Conectoma/métodos , Rede Nervosa/fisiopatologia , Transtorno Obsessivo-Compulsivo/fisiopatologia , Esquizofrenia/fisiopatologia , Adolescente , Adulto , Encéfalo/diagnóstico por imagem , Comorbidade , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Rede Nervosa/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/epidemiologia , Esquizofrenia/diagnóstico por imagem , Esquizofrenia/epidemiologia , Adulto Jovem
3.
Psychiatry Res Neuroimaging ; 276: 65-72, 2018 06 30.
Artigo em Inglês | MEDLINE | ID: mdl-29628272

RESUMO

Recent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.


Assuntos
Cerebelo/diagnóstico por imagem , Córtex Cerebral/diagnóstico por imagem , Substância Cinzenta/diagnóstico por imagem , Transtorno Obsessivo-Compulsivo/diagnóstico por imagem , Esquizofrenia/diagnóstico por imagem , Adolescente , Adulto , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Estudos de Casos e Controles , Cerebelo/patologia , Córtex Cerebral/patologia , Comorbidade , Feminino , Lobo Frontal/diagnóstico por imagem , Lobo Frontal/patologia , Substância Cinzenta/patologia , Giro do Cíngulo/diagnóstico por imagem , Giro do Cíngulo/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Córtex Motor/diagnóstico por imagem , Córtex Motor/patologia , Transtorno Obsessivo-Compulsivo/epidemiologia , Tamanho do Órgão , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/patologia , Córtex Pré-Frontal/diagnóstico por imagem , Córtex Pré-Frontal/patologia , Esquizofrenia/epidemiologia , Lobo Temporal/diagnóstico por imagem , Lobo Temporal/patologia , Tálamo/diagnóstico por imagem , Tálamo/patologia , Adulto Jovem
4.
Artigo em Inglês | MEDLINE | ID: mdl-29371026

RESUMO

OBJECTIVE: Olfactory identification impairments have been consistently found in schizophrenia patients. However, few previous studies have investigated this in first-episode patients. There are also inconsistent findings regarding olfactory identification ability in psychometrically-defined schizotypy individuals. In this study, we directly compared the olfactory identification ability of first-episode schizophrenia patients with schizotypy individuals. The relationship between olfactory identification impairments and hedonic traits was also examined. METHODS: Thirty-five first-episode schizophrenia patients, 40 schizotypy individuals as defined by the Chapman's Anhedonia Scales and 40 demographically matched controls were recruited. The University of Pennsylvania Smell Identification Test was administered. Hedonic capacity was assessed using the Temporal Experience of Pleasure Scale (TEPS). RESULTS: The results showed that both the schizophrenia and schizotypy groups showed poorer olfactory identification ability than controls, and the impairment was significantly correlated with reduced pleasure experiences. CONCLUSION: Our findings support olfactory identification impairment as a trait marker for schizophrenia.


Assuntos
Transtornos do Olfato/etiologia , Transtornos da Percepção/etiologia , Filosofia , Esquizofrenia/complicações , Transtorno da Personalidade Esquizotípica/complicações , Discriminação Psicológica , Feminino , Humanos , Masculino , Transtornos do Olfato/fisiopatologia , Transtornos do Olfato/psicologia , Percepção Olfatória , Reconhecimento Fisiológico de Modelo , Transtornos da Percepção/fisiopatologia , Transtornos da Percepção/psicologia , Esquizofrenia/fisiopatologia , Psicologia do Esquizofrênico , Transtorno da Personalidade Esquizotípica/fisiopatologia , Transtorno da Personalidade Esquizotípica/psicologia , Adulto Jovem
5.
J Abnorm Child Psychol ; 45(6): 1207-1219, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27917459

RESUMO

The current longitudinal study examined whether the personality vulnerabilities of self-criticism and dependency prospectively predicted stress generation in Chinese adolescents. Participants included 1,116 adolescents (588 girls and 528 boys), aged 15 to 18 years from rural, urban and ultra-urban mainland China. Participants completed self-report measures of personality, depressive and anxious symptoms and participated in a clinical interview assessing lifetime history of depression. The occurrence of negative life events was measured using a contextual-threat interview every 6-months for a total period of 18-months. Logistic regression analyses showed that after controlling for past depressive episodes and current depressive and anxious symptoms, self-criticism was prospectively associated with the occurrence of interpersonal stress generation, but not noninterpersonal stress generation. Dependency also predicted interpersonal stress generation, although only in girls and not boys. In line with previous Western findings, girls reported more interpersonal stress generation. Analyses across 3 levels of urbanization revealed several significant differences including higher reported interpersonal stress generation in urban girls than urban boys and overall higher levels of negative life events in ultra-urban youth. In sum, findings from the current study suggest that the stress generation process may be generalizable to Chinese youth.


Assuntos
Relações Interpessoais , Acontecimentos que Mudam a Vida , População Rural , Autoavaliação (Psicologia) , Estresse Psicológico/psicologia , População Urbana , Adolescente , China , Feminino , Humanos , Estudos Longitudinais , Masculino , Fatores Sexuais , Estresse Psicológico/etiologia
6.
J Affect Disord ; 168: 58-63, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25036010

RESUMO

OBJECTIVES: Childhood trauma is a major public health problem which has a long-term consequence, a few studies have examined the relationship between childhood trauma and clinical features of bipolar disorder, most in western culture, with no such studies done in Chinese culture. METHODS: The CTQ-SF was administered to 132 Chinese patients with DSM-IV bipolar disorder. Participants also completed the Childhood Experience of Care and Abuse Questionnaire (CECA.Q), the Impact of Events Scale-Revised (IES-R), and the State-Trait Anxiety Inventory (STAI). The CTQ-SF cut-off scores for exposure were used to calculate the prevalence of trauma. The relationship between childhood trauma and clinical features of bipolar disorder were examined. RESULTS: The internal consistency of CTQ-SF was good (Cronbach׳s α=0.826) and four week test-retest reliability was high (r=0.755). 61.4% of this sample reported physical neglect (PN) in childhood, followed by emotional neglect (EN, 49.6%), sexual abuse (SA, 40.5%), emotional abuse (EA, 26.0%) and physical abuse (PA,13.1%). Significant negative correlations existed between age of onset and EA and EN score (r=-0.178~-0.183, p<0.05). Significant positive correlations were observed between EA, CTQ-SF total score and intrusion and hyper-arousal scores of IES-R (r=0.223~0.309, p<0.05). Similarly, significant positive correlations were found between EN, PN, CTQ-SF total and STAI score (r=0.222~0.425, p<0.05). LIMITATIONS: Data on childhood trauma were derived from a retrospective self-report questionnaire without independent corroboration. A number of potential patients (more severe or chronic patients) was excluded because they were either refused to participate or inappropriate to participate in research. CONCLUSIONS: Significant number of subjects in patients with BD reported experience of childhood abuse and neglect. Exposure to childhood trauma is associated with age of onset of illness, co morbid PTSD and anxiety symptoms. To study the pathogenesis of childhood trauma on bipolar disorder and explanation the interaction between childhood trauma and susceptibility genes are proposed.


Assuntos
/psicologia , Transtorno Bipolar/etiologia , Adulto , Transtorno Bipolar/epidemiologia , Transtorno Bipolar/psicologia , Criança , Maus-Tratos Infantis/psicologia , China/epidemiologia , Comorbidade , Manual Diagnóstico e Estatístico de Transtornos Mentais , Feminino , Humanos , Masculino , Prevalência , Reprodutibilidade dos Testes , Autorrelato , Inquéritos e Questionários
7.
BMC Public Health ; 14: 551, 2014 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-24894449

RESUMO

BACKGROUND: Although there are accumulating data regarding the epidemiology of suicide in China, there are meager data on suicidal ideation and attempts among college students. Interestingly, elevated impulsivity is thought to facilitate the transition from suicidal thoughts to suicidal behavior. Therefore, the objective of this research was to identify the associations between suicide and the personality factors of impulsivity and aggression. METHODS: This study's sampling method employed stratified random cluster sampling. A multi-stage stratified sampling procedure was used to select participants (n = 5,245). We conducted structured interviews regarding a range of socio-demographic characteristics and suicidal morbidity. The Patient Health Questionnaire depression module (PHQ-9) was used to acquire the information about thoughts of being better off dead or hurting themselves in some ways during the past two weeks. The impulsivity symptoms in this study were assessed with the BIS-11-CH (i.e., the Chinese version of the BIS-11), and the Aggressive symptoms were assessed with the BAQ. The statistical package for social science (SPSS) v.13.0 program (SPSS Inc., Chicago, IL, USA) was used for statistical analysis. Socio-demographic variables such as ethnic and gender were compared between groups, through the use of χ2 tests. The nonparametric test (k Independent Sample test, Kruskal-Wallis H) was performed to determine differences between the personality factors of impulsivity and aggression and suicide. RESULTS: In total, 9.1% (n = 479) of the 5,245 students reported they have ever thought about committing suicide; and 1% (n = 51) reported a history of attempted suicide (attempters). The analyses detected significant differences in scores on cognitive impulsivity (p < 0.01), when comparing individuals who only had suicidal ideation and individuals who had attempted suicide. Moreover, significant differences were found between ideators only and attempters on scores of self-oriented attack (p < .001). CONCLUSIONS: Suicidal ideation is prevalent among Chinese university students. Students with high aggression scores were more susceptible to committing suicide. Scores on self-oriented attack and cognitive impulsivity may be important factors for differentially predicting suicide ideation and suicide attempts.


Assuntos
Agressão/psicologia , Comportamento Impulsivo , Estudantes/psicologia , Ideação Suicida , Suicídio/psicologia , Adolescente , Adulto , China/epidemiologia , Transtorno Depressivo/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Escalas de Graduação Psiquiátrica , Fatores de Risco , Fatores Socioeconômicos , Suicídio/estatística & dados numéricos , Tentativa de Suicídio/psicologia , Inquéritos e Questionários , Adulto Jovem
8.
Physiol Behav ; 129: 135-41, 2014 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-24582667

RESUMO

OBJECTIVE: Depression is a serious mental illness. However, the molecular mechanisms responsible for the development of depression remain unknown. METHODS: In this study, animal models of depression were established using maternal deprivation (MD) and chronic unpredictable stress (CUPS). Behavioral performance of rats was monitored by open field test, forced swim test, and sucrose consumption test. The expression of serotonin receptor-4 (Htr4) mRNA and Let-7a microRNA was detected by real-time PCR, while Htr4 protein level was measured by Western blot. RESULTS: In the open field test, rats subjected to MD and CUPS exhibited significant decreases in vertical activity. CUPS rats spent less time in the central area and excreted more fecal pellets than MD and control rats. In the forced swim and sucrose consumption tests, CUPS and MD rats exhibited significantly longer floating time and consumed less sucrose than control rats. MD rats exhibited significantly shorter floating time and consumed less sucrose than CUPS rats. MD rats showed significantly lower Htr4 mRNA and protein expression and significantly higher Let-7a level in the hippocampus than control rats. Htr4 mRNA and protein expression negatively correlated with Let-7a expression. Htr4 mRNA expression positively correlated with sucrose preference rate, while Let-7a expression negatively correlated with the sucrose preference rate. CONCLUSION: Anhedonia, not despair or a decline in exploratory interest, may be associated with upregulation of Let-7a and downregulation of Htr4 expression in the hippocampus. The hippocampal Htr4 level may be regulated by Let-7a in rats.


Assuntos
Anedonia/fisiologia , Hipocampo/metabolismo , MicroRNAs/metabolismo , Receptores 5-HT4 de Serotonina/metabolismo , Animais , Western Blotting , Doença Crônica , Transtorno Depressivo/etiologia , Transtorno Depressivo/metabolismo , Sacarose na Dieta/administração & dosagem , Ingestão de Alimentos/fisiologia , Comportamento Exploratório/fisiologia , Regulação da Expressão Gênica , Masculino , Privação Materna , MicroRNAs/genética , Testes Neuropsicológicos , RNA Mensageiro/metabolismo , Ratos Sprague-Dawley , Estresse Psicológico/complicações , Estresse Psicológico/metabolismo , Incerteza
9.
J Affect Disord ; 152-154: 530-3, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24144585

RESUMO

BACKGROUND: The 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR) is a newly introduced screening tool, while the Montgomery-Asberg Scale (MADRS) is commonly used in research and clinical practice in China. Converting the total scores between the two instruments could facilitate the comparison of different studies. METHODS: This study included 1164 patients with major depressive disorder (MDD). The diagnosis was established using the Mini International Neuropsychiatric Interview (MINI). The severity of depressive symptoms was assessed with the Chinese versions of MADRS (C-MADRS) and QIDS-SR (C-QIDS-SR) at baseline and 6 weeks later (exit point). Total scores of both scales were converted using Item Response Theory (IRT) analysis. RESULTS: At baseline, the C-MADRS and C-QIDS-SR were not unifactorial, therefore the conversion between them could not be performed. At exit, the C-MADRS and C-QIDS-SR were unifactorial, meeting the unidimensionality assumption of the IRT approach. Depression severity thresholds for the QIDS-SR are suggested as 6-10 for mild, 11-15 for moderate, 16-20 for severe, 21+ for very severe depression and ≤ 5 for remission (www.ids-qids.org). Based on the results of this study, the corresponding C-MADRS thresholds are 9-17 for mild, 18-24 for moderate, 25-33 for severe, 34+ for very severe depression and ≤ 7 or 8 (7.5) for remission. CONCLUSIONS: The conversion of C-QIDS-SR and C-MADRS total scores would help researchers understand findings across different studies using these scales.


Assuntos
Transtorno Depressivo Maior/diagnóstico , Escalas de Graduação Psiquiátrica , Adulto , China , Transtorno Depressivo Maior/psicologia , Feminino , Humanos , Masculino , Escalas de Graduação Psiquiátrica/normas , Autorrelato , Índice de Gravidade de Doença , Traduções
10.
BMC Psychiatry ; 13: 142, 2013 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-23683292

RESUMO

BACKGROUND: The serotonin transporter (5-HTT) gene may play an important role in the onset and development of mental disorders. Past studies have tested whether a functional polymorphism in the 5-HTT gene linked promoter region (5-HTTLPR) moderated the association between stress and depressive symptoms, but the results of these studies were inconsistent. Thus, the aim of the current study was to examine the interaction between 5-HTTLPR and stress that predict depressive symptoms in Chinese adolescents. METHODS: A total of 252 healthy adolescents (131 females and 121 males, aged from 14 to 18, mean = 16.00, standard deviation = 0.60) participated in this study. During the initial assessment, all participants completed the Center for Epidemiological Studies Depression Scale (CES-D) and Adolescent Life Events Questionnaire (ALEQ) and were genotyped for the 5-HTTLPR polymorphism. Participants subsequently completed CES-D and ALEQ once every three months during the subsequent 24 months. A multilevel model was used to investigate the 5-HTTLPR × stress interaction in predicting depressive symptoms. RESULTS: The results indicated no main effect of 5-HTTLPR and a significant 5-HTTLPR × stress interaction in females only. Females with at least one 5-HTTLPR S allele exhibited more depressive symptoms under stressful situations. No significant 5-HTTLPR × stress interaction was found in males. CONCLUSIONS: In Chinese adolescents, there are gender differences on the interaction between 5-HTTLPR and stress that predict depressive symptoms. The association between stress and depressive symptoms is moderated by 5-HTTLPR in Chinese female adolescents.


Assuntos
Depressão/genética , Interação Gene-Ambiente , Polimorfismo Genético , Regiões Promotoras Genéticas , Proteínas da Membrana Plasmática de Transporte de Serotonina/genética , Estresse Psicológico/psicologia , Adolescente , Alelos , Depressão/psicologia , Feminino , Genótipo , Humanos , Estudos Longitudinais , Masculino , Caracteres Sexuais , Estresse Psicológico/genética
11.
J Affect Disord ; 147(1-3): 421-4, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-22995944

RESUMO

BACKGROUND: Developing accurate and time-efficient tools to measure depressive symptoms is important for research and clinical practice. This study aimed to test the psychometric properties of the Chinese version of the 16-item Quick Inventory of Depressive Symptomatology - Clinician Rating (C-QIDS-C) and Self-Report (C-QIDS-SR). METHODS: This study included 998 patients with major depressive disorder (MDD) established using the Mini International Neuropsychiatric Interview (MINI). The severity of depressive symptoms was assessed using the Hamilton Rating Scale for Depression (HAMD), C-QIDS-C and C-QIDS-SR at baseline and 6 weeks later. RESULTS: Internal consistency (Cronbach's alpha) ranged from 0.73 to 0.82 for C-QIDS-C and C-QIDS-SR at both the baseline and exit. The involvement and energy domains at baseline, and sad mood, concentration/decision making, self outlook, involvement and agitation/retardation domains at exit had the highest item-total correlations across the two C-QIDS scales. The C-QIDS-C and C-QIDS-SR total scores were highly correlated with the HAMD total score at both baseline (r=0.61, p<0.01 and r=0.54, p<0.01, respectively) and exit (r=0.75, p<0.01 and r=0.72, p<0.01, respectively). The C-QIDS-C, C-QIDS-SR and HAMD were equally sensitive to change of depressive symptoms, suggesting high concurrent validity. The C-QIDS-C and C-QIDS-SR showed uni-dimensional measurement properties in exploratory factor analyses at both baseline and exit. CONCLUSIONS: The C-QIDS-C and C-QIDS-SR have excellent psychometric properties and are sensitive measurement of symptom severity in MDD.


Assuntos
Transtorno Depressivo Maior/diagnóstico , Escalas de Graduação Psiquiátrica , Adulto , China , Terapia Cognitivo-Comportamental , Transtorno Depressivo Maior/psicologia , Transtorno Depressivo Maior/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Psicometria , Autorrelato , Inibidores de Captação de Serotonina/uso terapêutico
12.
J Clin Child Adolesc Psychol ; 42(4): 531-44, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23237030

RESUMO

The present study examined the relation between attachment cognitions, stressors, and emotional distress in a sample of Chinese adolescents. Specifically, it was examined whether negative attachment cognitions predicted depression and anxiety symptoms, and if a vulnerability-stress or stress generation model best explained the relation between negative attachment cognitions and internalizing symptoms. Participants included 558 adolescents (310 females and 248 males) from an urban school in Changsha and 592 adolescents (287 female, 305 male) from a rural school in Liuyang, both in Hunan province located in mainland China. Participants completed self-report measures of negative attachment cognitions at baseline, and self-report measures of negative events, depression symptoms, and anxiety symptoms at baseline and at regular 1-month intervals for an overall 6-month follow-up (i.e., six follow-up assessments). Higher levels of negative attachment cognitions predicted prospective depression and anxiety symptoms. Furthermore, support was found for a stress generation model that partially mediated this longitudinal association. No support was found for a vulnerability-stress model. Overall, these findings highlight new developmental pathways for development of depression and anxiety symptoms in mainland Chinese adolescents.


Assuntos
Adaptação Psicológica , Cognição , Apego ao Objeto , Estresse Psicológico/diagnóstico , Adolescente , Ansiedade/diagnóstico , Ansiedade/psicologia , China , Depressão/diagnóstico , Depressão/psicologia , Emoções , Feminino , Humanos , Acontecimentos que Mudam a Vida , Masculino , Modelos Psicológicos , Estudos Prospectivos , Escalas de Graduação Psiquiátrica , Autorrelato , Estresse Psicológico/psicologia , Inquéritos e Questionários
13.
J Soc Clin Psychol ; 32(6): 596-618, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25798026

RESUMO

The present study examined the prospective relation between two personality predispositions, self-criticism and dependency, and internalizing symptoms. Specifically, it was examined whether self-criticism and dependency predicted symptoms of depression and social anxiety, and if a moderation (e.g. diathesis-stress) or mediation model best explained the relation between the personality predispositions and emotional distress in Chinese adolescents. Participants included 1,150 adolescents (597 females and 553 males) from mainland China. Participants completed self-report measures of self-criticism, dependency, and neuroticism at baseline, and self-report measures of negative events, depressive symptoms, and social anxiety symptoms once a month for six months. Findings showed that self-criticism predicted depressive symptoms, while dependency predicted social anxiety symptoms. In addition, support was found for a mediation model, as opposed to a moderation model, with achievement stressors mediating the relation between self-criticism and depressive symptoms. Overall, these findings highlight new developmental pathways for the development of depression and social anxiety symptoms in mainland Chinese adolescents. Implications for cross-cultural developmental psychopathology research are discussed.

14.
J Abnorm Psychol ; 120(4): 765-78, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21910514

RESUMO

The current multiwave longitudinal study examined the applicability of two cognitive vulnerability-stress models of depression-Beck's (1967, 1983) cognitive theory and the hopelessness theory (Abramson, Metalsky, & Alloy, 1989)-in two independent samples of adolescents from Hunan Province, China (one rural and one urban). During an initial assessment, participants completed measures assessing dysfunctional attitudes (Beck, 1967, 1983), negative cognitive style (Abramson et al., 1989), neuroticism (Costa & McCrae, 1992), depressive symptoms, and anxiety symptoms. Once a month for the subsequent 6 months, participants completed measures assessing the occurrence of different types of negative events, depressive symptoms, and anxiety symptoms. Results provided support for cognitive vulnerability factors as predictors of increases in depressive symptoms following the occurrence of higher than average levels of negative events in Chinese adolescents. The results also supported the specificity of these two cognitive vulnerability factors as predictors of depressive versus anxiety symptoms following the occurrence of higher than average levels of negative events (i.e., symptom specificity), and the ability of cognitive vulnerability factors to predict prospective change in depressive symptoms above and beyond the effects of trait neuroticism (i.e., etiological specificity).


Assuntos
Ansiedade/psicologia , Cognição , Depressão/psicologia , Teoria Psicológica , Estresse Psicológico/psicologia , Adaptação Psicológica , Adolescente , Análise de Variância , Ansiedade/epidemiologia , China/epidemiologia , Cultura , Depressão/epidemiologia , Depressão/patologia , Suscetibilidade a Doenças , Feminino , Humanos , Acontecimentos que Mudam a Vida , Estudos Longitudinais , Masculino , Negativismo , Escalas de Graduação Psiquiátrica , População Rural/estatística & dados numéricos , Autorrelato , Enquadramento Psicológico , Estresse Psicológico/epidemiologia , População Urbana/estatística & dados numéricos
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