Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 41
Filtrar
Mais filtros










Base de dados
Tipo de estudo
Intervalo de ano de publicação
1.
Biomed Pharmacother ; 125: 110032, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32187961

RESUMO

This study was devised to investigate if P-glycoprotein (P-gp) mediated the drug-drug interaction (DDI) between genistein and repaglinide. When genistein was added, the plasma concentrations of repaglinide in rats were increased. The maximum plasma concentration (Cmax) of repaglinide increased from 70.80 ± 7.98 ng/mL to 124.71 ± 9.02 ng/mL and the area under the plasma concentration-time curve (AUC) increased from 134.89 ± 13.65 µg·h/L to 245.95 ± 7.24 µg·h/L. Intestinal absorption of repaglinide was markedly enhanced by genistein or P-gp inhibitor verapamil (Ver), both in situ rat jejunal perfusion studies and in vitro transport assays using everted rat intestinal sac preparations. Furthermore, the accumulation of repaglinide in both Caco-2 cells and IEC-6 cells also increased significantly in the presence of genistein and Ver. The transepithelial transport rate of repaglinide from basolateral-to-apical in MDR1-MDCK cells was 3.6-fold higher than the apical-to-basolateral rate with a net efflux ratio of 1.92 compared with mock-MDCK cells, which was significantly decreased following co-administration with genistein or Ver. In an intracellular accumulation experiment using Rhodamine 123 as a P-gp substrate, genistein significantly increased the intracellular fluorescence of Rhodamine 123. These results indicated that genistein had an inhibitory effect on the efflux function of P-gp. Through molecular docking assays we further found that genistein could bind to the nucleotide-binding domains (NBD) in the cytoplasm of P-gp, thus affecting the functions of P-gp. In conclusion, genistein inhibited the efflux of repaglinide mediated by P-gp in rats and in vitro. The findings suggested that the DDI between genistein and repaglinide is mediated by P-gp, and a dosage adjustment may be needed when they are co-administered in a clinical setting.

2.
Public Health Nutr ; : 1-10, 2020 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-31910936

RESUMO

OBJECTIVE: The association of Fe metabolism with obesity in children remains unclear. The present study aimed to assess the status of Fe metabolism parameters, the prevalence of anaemia, Fe deficiency (ID) and Fe-deficiency anaemia (IDA), and the associations of these variables with obesity in Chinese schoolchildren. DESIGN: A cross-sectional study conducted in 5295 schoolchildren aged 7-11 years in Guangzhou, China, 2014-2015. Full data of anthropometric and Fe metabolic parameters were collected to assess obesity, anaemia, ID and IDA. Logistic regression models were established to determine the possible associations of anaemia, ID and IDA with obesity. Two-tailed P values of <0·05 was considered statistically significant. SETTING: Guangzhou City, China. PARTICIPANTS: Schoolchildren aged 7-11 years (n 5295). RESULTS: In this sample, mean Hb concentration was 128·1 g/l and the prevalence of anaemia, ID and IDA was 6·6, 6·2 and 0·6 %, respectively. Of the participants, 14·0 % were overweight and 8·8 % were obese. Importantly, obesity was associated with lower anaemia risk (adjusted OR = 0·553; 95 % CI 0·316, 0·968) but higher ID risk (adjusted OR = 1·808; 95 % CI 1·146, 2·853) after adjustment for confounders. No significant relationship was found between obesity and IDA. CONCLUSIONS: Our results confirmed that anaemia and ID remain public health concerns among schoolchildren in Guangzhou, while IDA is remarkably less prevalent. Furthermore, obesity was associated with lower anaemia risk, but higher ID risk. More efforts should be made to prevent the onset of ID and obesity in the same individual, thus improving the health and fitness of children.

3.
Public Health Nutr ; : 1-11, 2020 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-31915093

RESUMO

OBJECTIVE: High sugar-sweetened beverage (SSB) intake has been shown to correlate with a higher risk for CVD and metabolic disorders, while the association between SSB intake and the risk of metabolic syndrome (MetS) remains unclear. The present study aimed to explore the association between SSB intake and MetS among children and adolescents in urban China. DESIGN: A cross-sectional study involving 7143 children and adolescents was conducted in urban China. MetS definition proposed by the International Diabetes Federation was adopted. Data on SSB intake, diet, physical activity and family environment factors were obtained through questionnaires. Logistic regression models with multivariable adjustment were adopted to analyse the association between SSB intake and the risk of MetS and its components. SETTING: Primary and secondary schools in three urban cities of China. PARTICIPANTS: Children and adolescents (n 5258) aged 7-18 years. RESULTS: Among the participants, 29·9 % of them had high SSB intake (at least 0·3 servings/d) and the overall MetS prevalence was 2·7 %. Participants with high SSB intake were at higher risk for MetS (OR = 1·60; 95 % CI 1·03, 2·54) and abdominal obesity (OR = 1·55; 95 % CI 1·28, 1·83) compared with their counterparts with no SSB intake (0 servings/d). CONCLUSIONS: High SSB intake is significantly associated with increased MetS and abdominal obesity risk among children and adolescents in urban China. These results suggest that strong policies focusing on controlling SSB intake might be effective in preventing MetS and abdominal obesity.

4.
Br J Pharmacol ; 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-32000294

RESUMO

BACKGROUND AND PURPOSE: Diclofenac is a widely used nonsteroidal anti-inflammatory drug. However, adverse effects in the kidney limit its clinical application. The present study was aimed to evaluate the potential effect of cilastatin on diclofenac-induced acute kidney injury and to clarify the potential roles of renal organic anion transporters (OATs) in the drug-drug interaction between cilastatin and diclofenac. EXPERIMENTAL APPROACH: The effect of cilastatin was evaluated in diclofenac-induced acute kidney injury in mice. Human OAT1/3-transfected HEK293 cells and renal primary proximal tubule cells (RPTCs) were used to investigate OAT1/3-mediated transport and the cytotoxicity of diclofenac. KEY RESULTS: Cilastatin treatment decreased the pathological changes, renal dysfunction and elevated renal levels of oxidation products, cytokine production and apoptosis induced by diclofenac in mice. Moreover, cilastatin increased the plasma concentration and decreased the renal distribution of diclofenac and its glucuronide metabolite, diclofenac acyl glucuronide (DLF-AG). Similarly, cilastatin inhibited cytotoxicity and mitochondrial damage in RPTCs but did not change the intracellular accumulation of diclofenac. DLF-AG but not diclofenac exhibited OAT-dependent cytotoxicity and was identified as an OAT1/3 substrate. Cilastatin inhibited the intracellular accumulation and decreased the cytotoxicity of DLF-AG in RPTCs. CONCLUSION AND IMPLICATIONS: Cilastatin alleviated diclofenac-induced acute kidney injury in mice by restoring the redox balance, suppressing inflammation, and reducing apoptosis. Cilastatin inhibited OATs and decreased the renal distribution of diclofenac and DLF-AG, which further ameliorated the diclofenac-induced nephrotoxicity in mice. Cilastatin can be potentially used in the clinic as a therapeutic agent to alleviate the adverse renal reaction to diclofenac.

5.
J Atheroscler Thromb ; 2019 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-31827007

RESUMO

AIMS: Metabolic syndrome (MetS) has become a worldwide epidemic; however, few studies have described its status in Chinese children. This study aimed to estimate MetS status and its associations with geography, economic development, birth weight, and parental education of Chinese children and adolescents. METHODS: Data were derived from 15,045 participants aged 7-18 years across seven Chinese provinces. Physical measurement and blood tests were conducted to assess the five classical MetS components described by the International Diabetes Federation, including abdominal obesity (the essential component), high blood pressure, low high-density cholesterol (HDL-C), high triglyceride, and elevated fasting glucose (FG). Logistic regression was adopted to explore possible associations between MetS and other factors. RESULTS: Overall, MetS prevalence was 2.3%, higher in males (2.8% vs. 1.7% in females), northern regions (3.1%), more developed regions (2.9%), and older participants (aged 16-18 years) (P<0.05 for all). Among the five MetS components, abdominal obesity and low HDL-C level were most prevalent (21.8% and 14.4%), and 35.9% of the participants had at least one component. In logistic regression, MetS itself did not correlate with birth weight or parental education. High birth weight was positively correlated with abdominal obesity (odds ratio, 1.48) butnegatively associated with elevated FG (odds ratio, 0.49). Concusions: MetS itself was not common in Chinese children and adolescents, whereas its certain components were far more prevalent. Children from North China, more-developed areas, and at an older age were more likely to develop MetS. Strategies designed to prevent pediatric MetS in China should focus on prevalent components as well as its geographic and economic development predilections.

6.
BMC Public Health ; 19(1): 1725, 2019 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-31870330

RESUMO

BACKGROUND: With rapid development of China's economy, there were over 68.7 million left-behind children (LBC) in China whose mental health has become a problem of public concern. The present cross-sectional study aimed to investigate the status of mental health and its associated factors of LBC aged 3-16 years old in both rural and urban areas. METHODS: A total of 4187 children (aged 3-16), including 1471 LBC and 2716 non-left-behind children (NLBC), were recruited from 50 communities (22 in urban areas and 28 in rural areas) in Guangdong, China in August, 2014. The mental health problems were assessed using the Strength and Difficulties Questionnaire (SDQ). RESULTS: No statistically significant difference of SDQ subscales scores about difficulties were found between LBC and NLBC on the whole participants as well as in rural areas or in urban areas within the same age group after adjustments were made (all p > 0.05). However, compared with NLBC in the same areas, urban LBC tended to have higher prosocial behaviours scores, while rural LBC had the lowest prosocial behaviours scores not only in the whole age group but also in different age subgroups (p < 0.05). Besides, compared with urban LBC, rural LBC were not worse in SDQ subscales scores except for prosocial behaviour at 7-9 age group (p = 0.003). Furthermore, higher paternal educational level and longer duration of parental absence, were associated with less difficulties in both rural and urban LBC. Besides, shorter duration of talk per-time but higher communication frequency were associated with less difficulties in rural LBC. CONCLUSIONS: The present study demonstrated that in general, no difference of mental health problems were found between LBC and NLBC. Besides, longer duration of parental absence, shorter duration of talk per time but more communication frequency, and higher paternal educational level tend to have better development of mental health. The findings reinforce the importance of the stability of caregivers and the effective parent-child communication for Chinese rural LBC.


Assuntos
Criança Abandonada/psicologia , Saúde Mental/estatística & dados numéricos , Adolescente , Criança , Criança Abandonada/estatística & dados numéricos , Pré-Escolar , China , Estudos Transversais , Feminino , Humanos , Masculino , Fatores de Risco , População Rural/estatística & dados numéricos , População Urbana/estatística & dados numéricos
7.
Acta Pharm Sin B ; 9(5): 986-996, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31649848

RESUMO

Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed. In present study, the potential roles of renal organic anion transporters (OATs) in alleviating the nephrotoxicity of imipenem by cilastatin were investigated in vitro and in rabbits. Our results indicated that imipenem and cilastatin were substrates of hOAT1 and hOAT3. Cilastatin inhibited hOAT1/3-mediated transport of imipenem with IC50 values comparable to the clinical concentration, suggesting the potential to cause a clinical drug-drug interaction (DDI). Moreover, imipenem exhibited hOAT1/3-dependent cytotoxicity, which was alleviated by cilastatin and probenecid. Furthermore, cilastatin and probenecid ameliorated imipenem-induced rabbit acute kidney injury, and reduced the renal secretion of imipenem. Cilastatin and probenecid inhibited intracellular accumulation of imipenem and sequentially decreased the nephrocyte toxicity in rabbit primary proximal tubule cells. Renal OATs, besides DHP-I, was also the target of interaction between imipenem and cilastatin, and contributed to the nephrotoxicity of imipenem. This therefore gives in part the explanation about the mechanism by which cilastatin protected against imipenem-induced nephrotoxicity. Thus, OATs can potentially be used as a therapeutic target to avoid the renal adverse reaction of imipenem in clinic.

8.
Environ Technol ; : 1-11, 2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31633453

RESUMO

ABSTRACTResource-based cities rise in the process of industrialization in China. These cities provide important resources for economic development of the country. However, due to the long-term and high-intensity exploitation of resources, resource-based cities are generally facing serious environmental pollution and ecological damages, which seriously threaten the survival and development of them. In order to evaluate and monitor ecological vulnerability of resource-based cities effectively, and solve the problem of fuzziness and randomness in the evaluation process, a comprehensive evaluation model based on entropy-set pair analysis has been built. First, the evaluation index system of resource-based cities' ecological vulnerability is constructed from four aspects of resource, economy, society and ecological environment. Second, the paper gets weights by entropy and evaluates vulnerability using the set pair theory. Finally, the level of ecological vulnerability of the case city is confirmed according to the principle of maximum connection degree. The results show that the evaluation indexes of resource, economy, society and ecological environment fluctuated but improved eventually in the year 2010 to 2016. And during this period, the ecological vulnerability of the case city changed from IV level to II level with a fluctuating state.

9.
BMJ Open ; 9(8): e030084, 2019 08 20.
Artigo em Inglês | MEDLINE | ID: mdl-31434778

RESUMO

INTRODUCTION: Successful surgical treatment of congenital heart disease improves neonates' long-term survival and leads to catch-up growth, which however does not occur in part of the patient population for largely undetermined reasons. METHODS AND ANALYSIS: A multicentre, prospective cohort study is being conducted in four paediatric medical institutions in China to collect detailed nutritional, anthropometric and clinical data at perioperative phases and during a 1-year period of follow-up after surgery. The study is expected to recruit approximately 5000 patients by the year of 2023 when the cohort is fully established. The primary endpoint of this study is the occurrence of postoperative catch-up growth, which will be determined in both absolute and relative terms (ie, reduced anthropometric deficits from the reference measures and improved z-scores that have passed the -2 SD cut-offs). Multivariable regression analyses will be performed to identify factors that are statistically significantly associated with the absence of postoperative catch-up growth. ETHICS AND DISSEMINATION: The protocol of this study has been approved by the individual ethics committees of the participating centres (Guangzhou Women and Children's Medical Centre (2008071601), the Children's Hospital of Zhejiang University School of Medicine (2018-IRB-094), Gansu Provincial Maternity and Child-Care Hospital (2019-IRB-01) and Zhengzhou Cardiovascular Hospital (2019012001)). Written informed consent from parents will be obtained before study entry. Findings of this study will be disseminated through publications in international peer-reviewed journals and will be presented in academic conferences.

10.
BMC Public Health ; 19(1): 558, 2019 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-31088522

RESUMO

BACKGROUND: The relationship between sleep duration and food intake is unclear. This study aims to examine the relationship among children aged 6-17 years in China. METHODS: The sample consisted of 70,519 children aged 6-17 years, which were randomly selected from 7 representative areas from China, from September to November, 2013. In the structured questionnaire, children reported daily sleep hours (less than 7 h, 7-9 h and more than 9 h), weekly food intake amount (including vegetables, fruit, sugar beverages and meat), physical activity and sedentary time. The relationship of sleep duration with vegetable, sugar beverage, fruit and meat intake was evaluated by multi-nominal logistic regression and multi-variable adjusted. RESULTS: A total of 62,517 children (51.6% boys) completed the study. Short sleep duration (SSD, < 7 h) was independently associated with increased sugar beverage intake (SBI, Odd Ratio, OR: 1.29, 95% CI: 1.19-1.40) but decreased vegetable (VI, OR: 0.94, 95% CI: 0.90-0.98) & fruit intake (FI, OR: 0.94, 95% CI: 0.88-0.99). Stratified by age and gender, SSD increased SBI for boys of both young (6-12 years) & older (13-17 years) groups and older girls (ORs: 1.25, 1.25, 1.49, 95% CI: 1.08-1.44, 1.04-1.50, 1.22-1.81, respectively), but decreased VI and FI for older girls (ORs: 0.84& 0.81, 95% CI: 0.74-0.96& 0.68-0.96, respectively). CONCLUSIONS: Among school-aged children in China, short sleep duration was associated with increased risks of more sugar beverage intake among those younger and boys but less vegetable & fruit intake among those older and girls. Longitudinal research is needed to clarify the causation in between.


Assuntos
Dieta/estatística & dados numéricos , Ingestão de Alimentos/fisiologia , Sono/fisiologia , Fatores de Tempo , Adolescente , Bebidas/análise , Criança , China , Estudos Transversais , Açúcares da Dieta/análise , Exercício , Feminino , Frutas , Humanos , Modelos Logísticos , Masculino , Razão de Chances , Inquéritos e Questionários , Verduras
11.
Lipids Health Dis ; 18(1): 50, 2019 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-30755213

RESUMO

BACKGROUND: Information on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association between iron metabolism and dyslipidaemia risk. METHOD: In total, 1866 children and adolescents aged 7-18 were enrolled in this study, including 912 boys and 954 girls. In this cross-sectional study, parameters for anthropometry, lipids and iron metabolism including transferrin, soluble transferrin receptor (sTfR), ferritin and serum iron (SF) were evaluated. Data regarding demographic characteristics, diet, and physical activity were collected by self-reported questionnaires. RESULTS: The prevalence of dyslipidaemia and iron deficiency in children and adolescents increased based on BMI categories (both P < 0.05) and were 58.3 and 8.9% in subjects with obesity, respectively. The lowest SF and the highest ferritin levels were observed in subjects who were obese (both P < 0.001). Subjects with dyslipidaemia had lower SF, transferrin and sTfR levels by different BMI categories, and those who were obese had higher ferritin levels (all P < 0.05). Most importantly, higher concentrations of transferrin and sTfR were related to lower dyslipidaemia risk (OR for transferrin: 0.49, 95% CI: 0.33-0.71; OR for sTfR: 0.68, 95% CI: 0.46-0.99). CONCLUSIONS: A downward trend in SF level by BMI categories and the highest ferritin level in subjects with obesity suggested that iron storage was associated with BMI in children and adolescents. Moreover, an inverse relationship was observed between transferrin and sTfR concentrations and dyslipidaemia risk in children with different BMI.


Assuntos
Anemia Ferropriva/sangue , Dislipidemias/sangue , Ferritinas/sangue , Ferro/sangue , Receptores da Transferrina/sangue , Transferrina/metabolismo , Adolescente , Anemia Ferropriva/complicações , Anemia Ferropriva/diagnóstico , Antropometria , Índice de Massa Corporal , Criança , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Estudos Transversais , Dieta , Dislipidemias/complicações , Dislipidemias/diagnóstico , Exercício , Feminino , Humanos , Masculino , Inquéritos e Questionários , Triglicerídeos/sangue
12.
JPEN J Parenter Enteral Nutr ; 43(5): 658-667, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30465333

RESUMO

BACKGROUND: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes. METHOD: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates. RESULTS: Across NICUs, large differences were observed for time to reach full enteral feeding (TFF; 8-33 days), weight gain (5.0-14.6 g/kg/day), ∆z-scores (-0.54 to -1.64), incidence of NEC (1%-13%), and mortality (1%-18%). Adjusted for gestational age, GD units had longer TFF (26 vs 11 days), lower weight gain (8.7 vs 10.9 g/kg/day), and more days on antibiotics (17 vs 11 days; all P < .001) than non-GD units, but NEC incidence and mortality were similar. CONCLUSION: Feeding practices for VLBW infants vary markedly around the world. Use of formula and long TFF in South China was associated with more use of antibiotics and slower weight gain, but apparently not with more NEC or higher mortality. Both infant- and hospital-related factors influence feeding practices for preterm infants. Multicenter, randomized controlled trials are required to identify the optimal feeding strategy during the first weeks of life.

13.
Toxicol Lett ; 295: 195-204, 2018 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-29964132

RESUMO

The present study aimed to investigate the regulation of JBP485 on the expressions of renal organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp), which can accelerate the renal excretion of accumulated endogenous toxins to attenuate vancomycin-induced nephrotoxicity (VIN) in rats. Vancomycin suppressed the mRNA and protein expressions of Oat1, Oat3, Oct2, Mrp2 and P-gp to reduce the renal excretion of endogenous toxins (e.g. indoxyl sulfate). However, JBP485 could reverse these effects and improved the pathological condition and morphology of rat kidney with a decrease in wet weight. Moreover, JBP485 decreased the number of apoptosis cells in TUNEL staining as well as reversed the decreased expression of B-cell lymphoma-2 (Bcl-2) and the increased expressions of Bcl-2-like protein 4 (Bax) and Caspase-3 in rat kidney. In addition, JBP485 also increased the level of superoxide dismutase (SOD) and decreased the level of malondialdehyde (MDA) in rat kidney. But JBP485 did not affect the plasma concentrations of vancomycin. In conclusion, the mechanism of VIN might be involved in, at least in part, suppressing the expressions of Oat1, Oat3, Oct2, Mrp2 and P-gp, and JBP485 could attenuate VIN in rats.


Assuntos
Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo , Transportadores de Cassetes de Ligação de ATP/metabolismo , Nefropatias/prevenção & controle , Rim/efeitos dos fármacos , Proteína 1 Transportadora de Ânions Orgânicos/metabolismo , Transportadores de Ânions Orgânicos Sódio-Independentes/metabolismo , Transportador 2 de Cátion Orgânico/metabolismo , Peptídeos Cíclicos/farmacologia , Vancomicina , Subfamília B de Transportador de Cassetes de Ligação de ATP/genética , Transportadores de Cassetes de Ligação de ATP/genética , Animais , Apoptose/efeitos dos fármacos , Proteínas Reguladoras de Apoptose/metabolismo , Citoproteção , Modelos Animais de Doenças , Regulação da Expressão Gênica , Rim/metabolismo , Rim/patologia , Nefropatias/induzido quimicamente , Nefropatias/metabolismo , Nefropatias/patologia , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Proteína 1 Transportadora de Ânions Orgânicos/genética , Transportadores de Ânions Orgânicos Sódio-Independentes/genética , Transportador 2 de Cátion Orgânico/genética , Estresse Oxidativo/efeitos dos fármacos , Ratos Wistar , Eliminação Renal/efeitos dos fármacos
14.
BMC Public Health ; 18(1): 615, 2018 05 11.
Artigo em Inglês | MEDLINE | ID: mdl-29747605

RESUMO

BACKGROUND: The relationship between sleep duration and overweight risk remains unexplored among Chinese children. This study aims to evaluate this association in a national investigation with school-aged population. METHODS: There were 18,302 normal weight children in this Chinese national study which conducted during 2013-2014 included in the research. Anthropometric measurements were performed both at baseline and after 6-9 month. Sleep duration, physical activity, food intake and social economic information were collected by self-report questionnaire. Overweight was defined according to the updated Chinese criterion. Cox regression was used to evaluate the relationships between sleep duration and overweight incidence with multivariable adjusted. RESULTS: In total, there were 443 new overweight cases recorded at the end of observation. Overweight incidence with greater than 9 h (long sleep duration, LSD), 7 to 9 h (middle sleep duration, MSD), and less than 7 h of sleep (short sleep duration, SSD) were 2.7, 3.1 and 3.3% respectively. Stratified by gender and compared with LSD, the hazard ratio (HR) of overweight for females with MSD was 1.60 (95% CI: 1.02-2.52). Stratified by age and gender, the HR in the group of MSD was 2.13 (1.20-3.77) in female aged 6-10 years and 0.24 (0.06-0.93) in female aged 15-17 years. CONCLUSION: The association between short sleep duration and overweight is age- and gender dependent. In group of small age and elder age, girls' adiposity states are independently associated with sleep duration. Sleep recommendation is a potential preventive action for overweight/obesity among girls.


Assuntos
Obesidade Pediátrica/epidemiologia , Sono , Estudantes/estatística & dados numéricos , Adolescente , Distribuição por Idade , Criança , China/epidemiologia , Feminino , Seguimentos , Humanos , Incidência , Masculino , Fatores de Risco , Autorrelato , Distribuição por Sexo , Fatores de Tempo
15.
Zhongguo Dang Dai Er Ke Za Zhi ; 20(4): 314-317, 2018 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-29658458

RESUMO

OBJECTIVE: To explore the abilities of verbal and visual-spatial memory in Chinese children with developmental dyslexia. METHODS: Thirty-two children with developmental dyslexia (aged 8-12 years) and thirty-nine age- and gender-matched normal children were involved in the study. Their verbal short-term and verbal working memories were measured using the digit ordering and the digit span tests, respectively. Their visual-spatial short-term and visual-spatial working memories were examined using the forward and backward block-tapping tests, respectively. RESULTS: The DD children scored lower in the digit ordering and the digit span tests than the control children (P<0.05). The scores for the forward and backward block-tapping tests did not vary between the two groups (P>0.05). CONCLUSIONS: The children with DD have the deficits in both verbal short-term memory and verbal working memory.


Assuntos
Dislexia/psicologia , Memória de Curto Prazo , Memória Espacial , Criança , Feminino , Humanos , Masculino
16.
J Atheroscler Thromb ; 25(1): 81-89, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-28652525

RESUMO

AIMS: Excessive consumption of sugar-sweetened beverages (SSBs) may increase the prevalence of obesity and other metabolic risk factors. However, data regarding the relationship between SSB consumption and metabolic risk factors are insufficient in Chinese children. Hence, we aimed to explore the association between SSB consumption and cardio-metabolic risk factors in children aged 7-18 years living in South China. METHODS: A cross-sectional study was conducted in a total of 2,032 children aged 7-18 years were enrolled, including 1,013 boys and 1,019 girls. Based on a multistage cluster sampling, five elementary and four secondary schools in Guangzhou, China were included. Fasting blood glucose levels, lipid profiles, and anthropometric characteristics were evaluated. Information on demography, dietary, and physical activities were self-reported. RESULTS: Overall, 34.7% participants were non-drinkers and 21.6% consumed more than 120 mL/day SSB. The body mass index (19.43±0.18 kg/m2) and triglyceride concentration (0.96±0.03 mmol/L) were higher and high-density lipoprotein concentration (1.32±0.31 mmol/L) was lower in consumers than in non-consumers (all P<0.001). Furthermore, in contrast to non-consumers, the adjusted odds ratio of SSB consumption more than 120 mL/day was 2.08 (95% CI: 1.21-3.54) for obesity, 1.83 (95% CI: 1.25-2.69) for abdominal obesity, and 1.70 (95% CI: 1.02-3.06) for hypertriglyceridemia in consumers. CONCLUSION: A positive association between SSB consumption and the risks of obesity and hypertriglyceridemia was observed in children living in South China, which suggests that high SSB consumption enhances the risk of cardio-metabolic risk factors and the consequent cardio-metabolic diseases.


Assuntos
Bebidas , Hipertrigliceridemia/etiologia , Hipertrigliceridemia/prevenção & controle , Obesidade Pediátrica/etiologia , Obesidade Pediátrica/prevenção & controle , Açúcares/efeitos adversos , Edulcorantes/efeitos adversos , Adolescente , Antropometria , Glicemia/química , Criança , China , Análise por Conglomerados , Estudos Transversais , Comportamento Alimentar , Feminino , Promoção da Saúde , Humanos , Estilo de Vida , Lipídeos/química , Lipoproteínas HDL/metabolismo , Masculino , Razão de Chances , Fatores de Risco
17.
Environ Technol ; 39(23): 3013-3019, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28832258

RESUMO

With the large exploitation of mineral resources, a series of problems have appeared in the ecological environment of the mining area. Therefore, evaluating the ecological security of mining area is of great significance to promote its healthy development. In this paper, the evaluation index system of ecological security in mining area was constructed from three dimensions of nature, society and economy, combined with Pressure-State-Response framework model. Then network analytic hierarchy process and GRAY relational analysis method were used to evaluate the ecological security of the region, and the weighted correlation degree of ecological security was calculated through the index data of a coal mine from 2012 to 2016 in China. The results show that the ecological security in the coal mine area is on the rise as a whole, though it alternatively rose and dropped from 2012 to 2016. Among them, the ecological security of the study mining area is at the general security level from 2012 to 2015, and at a relatively safe level in 2016. It shows that the ecological environment of the study mining area can basically meet the requirement of the survival and development of the enterprises.


Assuntos
Fator Natriurético Atrial , Conservação dos Recursos Naturais , China , Ecologia , Modelos Teóricos
18.
Int J Pharm ; 537(1-2): 172-182, 2018 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-29277663

RESUMO

This study aimed to demonstrate that organic anion transporters (OATs) mediate the drug-drug interaction (DDI) between piperacillin and tazobactam. After co-administration with piperacillin in rats, the AUC of tazobactam in plasma was significantly increased, and t1/2ß was prolonged with significant reduction in plasma clearance, renal clearance and cumulative urinary excretion. In rat and human kidney slices, probenecid, p-aminohippurate and benzylpenicillin inhibited the uptake of piperacillin and tazobactam. Piperacillin significantly inhibited the uptake of tazobactam. Moreover, the uptakes of piperacillin, tazobactam and sulbactam in hOAT1/3-HEK293 cells were significantly higher compared with mock-HEK293 cells, respectively. Piperacillin significantly inhibited the uptake of tazobactam in hOAT1/3-HEK293 cells. The Km values of tazobactam (431 ±â€¯67 µM for hOAT1, 377 ±â€¯63 µM for hOAT3) were significantly higher than those of piperacillin (37 ±â€¯5 µM for hOAT1, 172 ±â€¯28 µM for hOAT3). This suggested that piperacillin has a stronger affinity to hOAT1/3 than tazobactam. Meanwhile, the Km values of tazobactam were increased in the presence of piperacillin with unchanged Vmax. This indicated that piperacillin inhibited the uptake of tazobactam in a competitive manner. In conclusion, piperacillin and tazobactam are the substrates of hOAT1/3, and OAT1/3 mediate the DDI between piperacillin and tazobactam.


Assuntos
Interações de Medicamentos/fisiologia , Proteína 1 Transportadora de Ânions Orgânicos/metabolismo , Transportadores de Ânions Orgânicos Sódio-Independentes/metabolismo , Ácido Penicilânico/análogos & derivados , Piperacilina/farmacologia , Animais , Linhagem Celular , Células HEK293 , Humanos , Rim/efeitos dos fármacos , Rim/metabolismo , Masculino , Ácido Penicilânico/farmacologia , Penicilina G/metabolismo , Probenecid/metabolismo , Ratos , Ratos Wistar , Sulbactam/farmacologia , Tazobactam , Ácido p-Aminoipúrico/metabolismo
19.
Nutrients ; 9(12)2017 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-29189729

RESUMO

We investigated the consumption of sugar-sweetened beverage (SSB) and its association with obesity and hypertension in a national sample of children and adolescents in China, where many low- and middle-income families live. Data were obtained from a 2014 national intervention program against obesity in Chinese children and adolescents aged 6-17 years. Height, weight, waist circumference, and blood pressure were measured. Information of SSB consumption, socioeconomic status, dietary intake, screen time, and physical activity were self-reported. Multivariate logistic regression was used to assess the association of SSB consumption with obesity and hypertension. A total of 66.6% of the 53,151 participants reported consuming SSB. The per capita and per consumer SSB intake were 2.84 ± 5.26 servings/week and 4.26 ± 5.96 servings/week, respectively. Boys, older children, and adolescents, and individuals with long screen time or high physical activity or low parental education level were more likely to consume SSB. Participants who were high SSB consumers had a higher odds ratio (1.133, 95% CI: 1.054-1.217) than non-consumers for having abdominal obesity after adjustment for age, sex, residence, socioeconomic status, diet, screen time, and physical activity. However, SSB consumption was not associated with general obesity or hypertension in children and adolescents. In conclusion, more than half of the children and adolescents in China consumed SSB, which was independently related to a high risk of abdominal obesity. The results of this study indicated that SSB reduction strategies and policies may be useful in preventing obesity among Chinese children and adolescents.


Assuntos
Bebidas , Hipertensão , Obesidade/etiologia , Açúcares/administração & dosagem , Açúcares/efeitos adversos , Adolescente , Criança , China , Estudos Transversais , Sacarose na Dieta , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Obesidade/epidemiologia , Fatores de Risco , Edulcorantes
20.
Nutr Metab (Lond) ; 13: 86, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27933092

RESUMO

BACKGROUND: It is becoming increasingly evident that platelet chemokines are involved in distinct aspects of atherosclerosis. The aim of this study was to examine the effects of long-term supplementation with purified anthocyanins on platelet chemokines in hypercholesterolemic individuals and to identify correlations of decreased platelet chemokine levels with serum lipid and inflammatory marker levels. METHODS: A total of 146 hypercholesterolemic individuals were recruited and treated with 320 mg of purified anthocyanins (n = 73) or a placebo (n = 73) daily for 24 weeks in this randomized, double-blind, placebo-controlled trial. RESULTS: Anthocyanin supplementation for 24 weeks significantly decreased the plasma CXCL7 (-12.32% vs. 4.22%, P = 0.001), CXCL5 (-9.95% vs. 1.93%, P = 0.011), CXCL8 (-6.07% vs. 0.66%, P = 0.004), CXCL12 (-8.11% vs. 5.43%, P = 0.023) and CCL2 levels (-11.63% vs. 12.84%, P = 0.001) compared with the placebo. Interestingly, the decreases in the CXCL7 and CCL2 levels were both positively correlated with the decreases in the serum low-density lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein (hsCRP) and interleukin-1ß (IL-1ß) levels after anthocyanin supplementation for 24 weeks. The decrease in the CXCL8 level was negatively correlated with the increase in the how-density lipoprotein-cholesterol (HDL-C) level and was positively correlated with the decrease in the soluble P-selectin (sP-selectin) level in the anthocyanin group. In addition, a positive correlation was observed between the decreases in the CXCL12 and tumornecrosis factor-α (TNF-α) levels after anthocyanin supplementation. However, the plasma CXCL4L1, CXCL1, macrophage migration inhibitory factor (MIF) and human plasminogen activator inhibitor 1 (PAI-1) levels did not significantly change following anthocyanin supplementation. CONCLUSIONS: The present study supports the notion that platelet chemokines are promising targets of anthocyanins in the prevention of atherosclerosis. TRIAL REGISTRATION: ChiCTR-TRC-08000240. Registered: 10 December 2008.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA