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1.
Artigo em Inglês | MEDLINE | ID: mdl-32225026

RESUMO

PURPOSE: The purpose of this study was to investigate the influence of natural environmental factors on the spatial distribution of marathon events in China, and to identify the suitable natural environmental factors for the marathon events. METHODS: Geographic information system (GIS) spatial analysis tools were used to perform coupling analysis, e.g. overlap, neighborhood, intersection and buffer for terrain, climate, air quality, mountains and water resources with 342 marathon events held in China in 2018. RESULTS: The results indicate that the spatial distribution of marathon events in China is negatively correlated with the elevation of the terrain (plain > hill > plateau > mountain > basin); climate (subtropical monsoon climate > temperate monsoon climate > temperate continental climate > tropical monsoon climate > plateau alpine climate), air quality (level 3 > level 2 > level 4 > level 1). Results indicate that buffer zones can protect water resources: there are 24 items in the buffer zone of river 0.5 km and lake 1 km, 131 items in the buffer zone of river 3 km and lake 5 km, 191 items in the buffer zone of river 5 km and lake 10 km, 298 items in the buffer zone of river 10 km and lake 20 km. Results indicate for mountain range buffer: 13 items in the 20 km buffer and 39 items in the 50 km buffer. CONCLUSIONS: Marathon events are more likely to be held on the third rung of China's topography where a city has a typical landform (plains, basins, hills, or mountain) with good climate and air quality. Meanwhile a city with water and mountain resources for recreational events such as cross-country or obstacle course are essential. The contribution of this study is to systematically and intuitively reflect the influence of natural environment factors on the distribution of marathon events in China, and to provide evidence for the medium and long-term planning of marathon events in China, the selection of venues for different types of marathon events and how to attract participants.

2.
Int J Nanomedicine ; 15: 521-536, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32021192

RESUMO

Introduction: The myelodysplastic syndromes (MDS) are a very heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increase risk of transformation to acute myeloid leukemia (AML). Daunorubicin (DNR) is an indispensable drug for the treatment of MDS and AML. However, its side effects including cardiac toxicity and bone marrow suppression severely limit clinical application. Many researches reported high expression of CD123 antigen on high-risk MDS cells, so we constructed a novel drug delivery system comprising daunorubicin-loaded CdTe QDs conjugated with anti-CD123 mAbs (DNR-CdTe-CD123) to develop targeted combination chemotherapy for MDS. Methods: CdTe conjugated antiCD123 through amide bond, co-loaded with DNR with electrostatic bonding. Then, we determined characterization and release rate of DNR-CdTe-CD123. The therapeutic effect and side effect of drug delivery system were evaluated through in vitro and in vivo experiments. Results: CdTe showed appropriate diameter and good dispersibility and DNR was loaded into CdTes with high encapsulation efficiency and drug loading. The maximum drug loading and encapsulation efficiency were 42.08 ± 0.64% and 74.52 ± 1.81%, respectively, at DNR concentration of 0.2mg/mL and anti-CD123 mAbs volume of 5ul (100ug/mL). Flow cytometry (FCM) showed that CD123 antigen was highly expressed on MUTZ-1 cells, and its expression rate was 72.89 ± 10.67%. In vitro experiments showed that the inhibition rate and apoptosis rate of MUTZ-1 cells treated with DNR-CdTe-CD123 were higher than those in the other groups (P<0.05). Compared with the other groups, the level of apoptosis-related protein (P53, cleaved caspase-9, Bax and cleaved caspase-3) were upregulated in DNR-CdTe-CD123 group (P<0.05). In vivo experiments, DNR-CdTe-CD123 can effectively inhibit the tumor growth of MDS-bearing nude mice and reduce the side effects of DNR on myocardial cells. Conclusion: The system of DNR-CdTe-CD123 enhances the therapeutic effects and reduce the side effects of DNR, thus providing a novel platform for MDS treatment.


Assuntos
Compostos de Cádmio/química , Daunorrubicina/administração & dosagem , Sistemas de Liberação de Medicamentos/métodos , Síndromes Mielodisplásicas/tratamento farmacológico , Telúrio/química , Animais , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais/farmacologia , Apoptose/efeitos dos fármacos , Caspase 3/metabolismo , Daunorrubicina/farmacologia , Humanos , Subunidade alfa de Receptor de Interleucina-3/imunologia , Camundongos Endogâmicos BALB C , Camundongos Nus , Síndromes Mielodisplásicas/patologia , Pontos Quânticos/química , Testes de Toxicidade , Ensaios Antitumorais Modelo de Xenoenxerto
3.
Artigo em Inglês | MEDLINE | ID: mdl-31835745

RESUMO

The purpose of this study is to explore the spatial distribution pattern and influencing factors of the Chinese marathon. Geographic Information System (GIS) related spatial analysis tools were used to calculate the following-averaged nearest neighbor index, nuclear density analysis and hot spot analysis among others. The spatial distribution evolution characteristics and the influencing factors of eighteen Chinese marathon events in 2010, 129 in 2015 and 342 in 2018 were analyzed. The results show that (a) in 2010 the nearest neighbor ratio was 1.164714, Moran's I was -0.010165 (type: Random), in 2015 it was 0.502146, Moran's I was 0.066267 (type: Clustered) and in 2018 it was 0.531149 and Moran's I was 0.083485 (type: Clustered); (b) in 2010 there was a 333.6 km search radius; the core circle of the Yangtze River Delta was adopted. In 2015 and 2018, a search radius of 556 km was adopted, which was respectively obtained from the core circle of the Yangtze River Delta, the core circle of Beijing-Tianjin-Hebei and the core circle of East China; (c) according to the Z-value data, East China and North China in 2015 passed 95% confidence in five provinces and municipal hot spots, passed 90% confidence in three hot spots and passed 95% confidence in Chongqing Cold Point. In 2018, East China, North China, Central Region and eight other provinces and cities' hot spots passed 95% confidence, four hot spots passed 90% confidence, the Tibet Autonomous Region cold spot passed 90% confidence. Conclusion: The overall distribution of marathon events is greater in the eastern region than the western region, greater in the southern region than the northern region and greater in coastal regions than the inland regions; the nuclear density distribution has spread from the Yangtze River Delta mononuclear circle in 2010 to the core circle of the entire East China region. Moreover, it spread to North China, Central China and South China; the distribution of hot spots spread from Shanghai, Jiangsu and Zhejiang to the entire North China and East China regions. During the past thirty-eight years of development of the Chinese marathon, it has been divided into three stages due to different political, economic and social environments.

4.
IEEE Trans Image Process ; 27(8): 4145-4159, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29993634

RESUMO

Guided depth map enhancement based on Markov Random Field (MRF) normally assumes edge consistency between the color image and the corresponding depth map. Under this assumption, the low-quality depth edges can be refined according to the guidance from the high-quality color image. However, such consistency is not always true, which leads to texture-copying artifacts and blurring depth edges. In addition, the previous MRF-based models always calculate the guidance affinities in the regularization term via a non-structural scheme which ignores the local structure on the depth map. In this paper, a novel MRF-based method is proposed. It computes these affinities via the distance between pixels in a space consisting of the Minimum Spanning Trees (Forest) to better preserve depth edges. Furthermore, inside each Minimum Spanning Tree, the weights of edges are computed based on explicit edge inconsistency measurement model, which significantly mitigates texture-copying artifacts. To further tolerate the effects caused by noise and better preserve depth edges, a bandwidth adaption scheme is proposed. Our method is evaluated for depth map super-resolution and depth map completion problems on synthetic and real datasets including Middlebury, ToF-Mark and NYU. A comprehensive comparison against 16 state-of-the-art methods is carried out. Both qualitative and quantitative evaluation present the improved performances.

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