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1.
J Trace Elem Med Biol ; 50: 615-621, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29716762

RESUMO

Changes in zinc metabolism caused by aging and the institutionalization process may contribute to zinc deficiency in elderly individuals. Hypozincemia results in changes in glycemic, lipid, and inflammatory profiles. The aim of this study was to evaluate plasma zinc concentrations and their relationships with sociodemographic, dietary, inflammatory, and cardiometabolic biomarkers in institutionalized elderly individuals. A cross-sectional study was carried out including 255 elderly adults living in nursing homes. The associations between plasma zinc and dietary zinc intake, sociodemographic indicators, and glycemic, lipid, and inflammatory biomarkers were evaluated. Independent variables were analyzed according to quartiles of plasma zinc concentrations (Q1: <71.1 µg/dL; Q2: 71.1-83.3 µg/dL; Q3: <83.3-93.7 µg/dL; Q4: >93.7 µg/dL). The relationship between plasma zinc concentrations and predictor variables was also tested. In Q1, higher concentrations of the following variables were observed, compared with those in other quartiles: total cholesterol and low-density lipoprotein cholesterol (LDL-c; Q1 > Q2, Q3, Q4; all p <0.001); triglycerides (Q1 > Q3, Q4; all p < 0.001); interleukin (IL)-6 (Q1 > Q3, Q4; p = 0.024 and p = 0.010, respectively); tumor necrosis factor (TNF)-α (Q1 > Q3, p = 0.003). A significant reduction in plasma zinc concentrations was observed with increasing age-adjusted institutionalization time (Δ = - 0.10; 95% confidence interval [CI]: -0.18 to -0.01). The concentrations of total cholesterol (Δ = - 0.19; 95% CI: -0.23 to -0.15), LDL-c (Δ = - 0.19; 95% CI: -0.23 to -0.15), triglycerides (Δ = - 0.11; 95% CI: -0.16 to -0.06), IL-6 (Δ = - 1.41; 95% CI: -2.64 to -0.18), and TNF-α (Δ = - 1.04; 95% CI: -1.71 to -0.36) were also significantly increased. In conclusion, decreased plasma zinc concentrations were associated with longer institutionalization time and worse lipid and inflammatory profiles in elderly institutionalized individuals.

2.
J Voice ; 2018 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-29678439

RESUMO

OBJECTIVES: This study aimed to estimate the prevalence and factors associated with voice disorders (VDs) in Brazilian community-dwelling older adults. STUDY DESIGN: This is a cross-sectional study. METHODS: The sample comprised 463 older adults (60 years or more) of both sexes living in a Brazilian northeastern city. Variables were related to socioeconomic and demographic profile, lifestyle, and general health conditions, in addition to the validated "Screening for Voice Disorders in Older Adults" (RAVI) questionnaire. A bivariate analysis was performed using the Pearson chi-square test or the Fisher exact test, and the magnitude of the association was the prevalence ratio (PR). Poisson regression model was performed, considering only the variables with a critical value of P < 0.20. The significance level was 5%. RESULTS: There was a prevalence of women (60.9%), and the average age of participants was 70 (±7.74) years. The prevalence of VDs was 51.4% (95% confidence interval [CI]: 46.8-55.9). The most common symptoms were throat sensation of phlegm (46.9%) and dry throat (46.7%), both related to physical sensations of laryngeal discomfort. Multivariate analysis indicated that the prevalence of VDs was independently associated with hyposalivation (PR = 2.28, 95% CI = 1.80-2.88), smoking (PR = 2.04, 95% CI = 1.65-2.52), self-reported hearing loss (PR = 1.51, 95% CI = 1.28-1.78), and not seeking a physician or other health professional care for VDs (PR = 0.73, 95% CI = 0.60-0.88). CONCLUSION: VDs are prevalent among Brazilian community-dwelling older adults and are associated with variables related to general health and lifestyle.

3.
Value Health Reg Issues ; 17: 8-13, 2018 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-29544112

RESUMO

OBJECTIVES: To identify the diseases that lead older persons to hospitalizations in the public health system in the state of Rio de Janeiro and, through a study of spatial distribution among hospitalization rates of the municipal districts, discuss the social contexts involved in the hospitalization of the elderly. METHODS: An ecological cross-sectional study using secondary data from the Brazilian hospital information system from the period 2009 to 2015 was performed. The hospitalization rates of people 60 years and older, residing in 92 municipalities in the state of Rio de Janeiro, were calculated. The municipal districts were grouped according to the similarity of such rates using K-means nonhierarchical clustering analysis. RESULTS: Diseases of the circulatory and respiratory systems, endocrine disorders, illnesses of the genitourinary system or the digestive tract, and certain infectious and parasitic diseases were the most discriminatory diseases for cluster composition. The first cluster, the municipal districts with the lowest hospitalization rates, which were more urbanized and had greater access to social and health services, was named Access and Inclusion. The second group, which had the highest hospitalization rates, was named Isolation and Vulnerability. CONCLUSIONS: The primary care-sensitive conditions are the main causes of hospitalization of the elderly in the state, with greater intensity in the municipalities that are geographically rugged and remote. These outcomes reinforce the importance of valuing geographical knowledge, the guidelines of the unified health system concerning equity and regionalization, and the determinants and social determinations involved in the process of health and disease.

4.
J Voice ; 31(4): 510.e15-510.e21, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28069466

RESUMO

OBJECTIVES: To estimate the prevalence and the associated factors with voice disorders (VDs) in older adults living in nursing homes. STUDY DESIGN: Cross-sectional. METHODS: A sample of 117 Brazilian individuals of both sexes and preserved cognitive function, aged >59 years, living in 10 nursing homes, was studied. VDs were screened using the validated tool "Rastreamento de Alterações Vocais em Idosos" (RAVI-Screening for Voice Disorders in Older Adults). Associated factors included variables related to socioeconomic and demographic profile; nursing home; general health; ear, nose, and throat conditions; lifestyle; functionality; and psychosocial status. Bivariate analysis was performed by Pearson's chi-square or Fisher's exact test. Multivariate analysis was performed by multiple binomial regression. The significance level was 5%. RESULTS: The prevalence of VDs was 39.3% (95% confidence interval [CI] = 30.4-48.1). There was no significant difference in prevalence according to age and sex. Multivariate analysis revealed that the prevalence of VDs were independently associated with anxiety symptoms (prevalence ratio [PR] = 1.97, 95% CI = 1.17-3.29), smoking (PR = 1.56, CI = 1.02-2.38), general daily inactivity (PR = 1.62, CI = 1.10-2.38), temporomandibular disorder (PR = 1.68, CI = 1.11-2.54), choking (PR = 1.53, CI = 1.06-2.20), and self-reported hearing loss (PR = 1.52, CI = 1.04-2.21). CONCLUSION: VDs are common among older adults with preserved cognitive function living in nursing homes. The associated factors with VDs in this population can be prevented, diagnosed, controlled, or treated. Screening procedures and early intervention should be considered.


Assuntos
Distúrbios da Voz/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Comorbidade , Estudos Transversais , Feminino , Humanos , Masculino , Casas de Saúde/estatística & dados numéricos , Prevalência
5.
BMC Oral Health ; 17(1): 5, 2016 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-27430364

RESUMO

BACKGROUND: Brazil has severe socioeconomic inequalities, resulting in major oral health problems for the Brazilian elderly, such as tooth loss and, consequently, a need for oral rehabilitation. The aim of this study was to evaluate inequalities in complete denture need among older Brazilian adults in relation to social determinants at individual and contextual levels. METHODS: This retrospective study was based on data from the national oral health survey, SB Brasil 2010, in which 7,619 older adults aged 65-74 years participated. The dependent variable was complete denture need. The independent variables at the first level were age, sex, race, and socioeconomic status. The independent variables that were used to identify inequality at the contextual level were geographic region of Brazil, the population of the municipality where the subject lived, whether the subject lived in the state capital or not, and the Human Development Index. In order to describe the socioeconomic characteristics, a socioeconomic cluster variable was created using the multivariable cluster analysis technique. Prevalence ratios (PRs) with 95 % confidence intervals (CIs) were determined to evaluate the effect of each variable. Two-level multivariable modeling was performed to examine the individual and contextual effects. RESULTS: There was a high prevalence of complete denture need among older Brazilian adults. The main factors associated with the prevalence of complete denture need were individual socioeconomic status (PR: 1.81; 95 % CI: 1.65-1.99), and the city-level contextual effect (PR: 1.20; 95 % CI: 1.08-1.34). CONCLUSIONS: Consistently poor rates of oral health rehabilitation were found among older Brazilian adults, and were associated with significant social inequality. Complete denture need was strongly associated with individual socioeconomic position. It was also verified that the Human Development Index, the city-level contextual effect, was associated with complete denture need.


Assuntos
Prótese Total , Disparidades em Assistência à Saúde , Saúde Bucal , Fatores Socioeconômicos , Idoso , Brasil , Estudos Transversais , Feminino , Humanos , Masculino , Estudos Retrospectivos
6.
Radiol Bras ; 49(2): 104-11, 2016 Mar-Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27141133

RESUMO

A solitary pulmonary nodule is a common, often incidental, radiographic finding. The investigation and differential diagnosis of solitary pulmonary nodules remain complex, because there are overlaps between the characteristics of benign and malignant processes. There are currently many strategies for evaluating solitary pulmonary nodules. The main objective is to identify benign lesions, in order to avoid exposing patients to the risks of invasive methods, and to detect cases of lung cancer accurately, in order to avoid delaying potentially curative treatment. The focus of this study was to review the evaluation of solitary pulmonary nodules, to discuss the current role of (18)F-fluorodeoxyglucose positron-emission tomography, addressing its accuracy and cost-effectiveness, and to detail the current recommendations for the examination in this scenario.

7.
Cien Saude Colet ; 21(4): 1217-26, 2016 Apr.
Artigo em Português | MEDLINE | ID: mdl-27076020

RESUMO

The aim of the study was to evaluate the perception of parents/caregivers regarding the financial impact of oral health problems on the families of preschool children. A preschool-based, cross-sectional study was conducted with 834 preschool children in Campina Grande, Brazil. Parents/caregivers answered the Early Childhood Oral Health Impact Scale. "Financial impact" was the dependent variable. Questionnaires addressing socio-demographic variables, history of toothache and health perceptions were administered. Clinical exams were performed by three dentists previously calibrated (Kappa: 0.85-0.90). Descriptive statistics were performed, followed by logistic regression for complex samples (α = 5%). The frequency of financial impact due to oral health problems in preschool children was 7.7%. The following variables were significantly associated with financial impact: parental perception of child's oral health as poor, the interaction between history of toothache and absence of dental caries and the interaction between history of toothache and presence of dental caries. It is concluded that often parents/caregivers reported experiencing a financial impact due to seeking treatment late, mainly by the presence of toothache and complications of the clinical condition.


Assuntos
Cárie Dentária/economia , Financiamento Pessoal , Saúde Bucal/economia , Brasil , Pré-Escolar , Estudos Transversais , Feminino , Custos de Cuidados de Saúde , Humanos , Masculino , Qualidade de Vida , Inquéritos e Questionários
8.
Radiol Bras ; 49(1): 35-42, 2016 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26933274

RESUMO

Solitary pulmonary nodule corresponds to a common radiographic finding, which is frequently detected incidentally. The investigation of this entity remains complex, since characteristics of benign and malignant processes overlap in the differential diagnosis. Currently, many strategies are available to evaluate solitary pulmonary nodules with the main objective of characterizing benign lesions as best as possible, while avoiding to expose patients to the risks inherent to invasive methods, besides correctly detecting cases of lung cancer so as the potential curative treatment is not delayed. This first part of the study focuses on the epidemiology, the morfological evaluation and the methods to determine the likelihood of cancer in cases of indeterminate solitary pulmonary nodule.

9.
Radiol Bras ; 49(1): 35-42, 2016 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26929459

RESUMO

Solitary pulmonary nodule corresponds to a common radiographic finding, which is frequently detected incidentally. The investigation of this entity remains complex, since characteristics of benign and malignant processes overlap in the differential diagnosis. Currently, many strategies are available to evaluate solitary pulmonary nodules with the main objective of characterizing benign lesions as best as possible, while avoiding to expose patients to the risks inherent to invasive methods, besides correctly detecting cases of lung cancer so as the potential curative treatment is not delayed. This first part of the study focuses on the epidemiology, the morfological evaluation and the methods to determine the likelihood of cancer in cases of indeterminate solitary pulmonary nodule.

10.
Asian Pac J Cancer Prev ; 17(1): 147-51, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26838200

RESUMO

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of these have been documented in association or preceded by oral epithelial dysplasia (OED). Aggressive cancers with fast growth have demonstrated overexpression of some glucose transporters (GLUTs). Thus, the aim of this study was to analyze the immunohistochemical expression of the glucose transporter, GLUT-1, in OEDs and OSCCs, seeking to better elucidate the biological behavior of neoplasias. Fifteen cases were selected this research of both lesions. Five areas were analyzed from each case by counting the percentage of positive cells at 400x magnification. Immunoreactivity of GLUT-1 was observed in 100% of the samples ranging from 54.2% to 86.2% for the OSCC and 73.9% to 97.4% for the OED. Statistical test revealed that there was greater overexpression of GLUT-1 in OED than the OSCC (p=0.01). It is believed the high expression of GLUT-1 may reflect the involvement of GLUT-1 in early stages of oral carcinogenesis.


Assuntos
Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/patologia , Transportador de Glucose Tipo 1/metabolismo , Neoplasias Bucais/metabolismo , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/metabolismo , Lesões Pré-Cancerosas/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/metabolismo , Feminino , Humanos , Imuno-Histoquímica/métodos , Masculino , Pessoa de Meia-Idade , Boca/metabolismo , Boca/patologia , Mucosa Bucal/metabolismo , Mucosa Bucal/patologia , Adulto Jovem
11.
J Voice ; 30(2): 246.e19-27, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25979791

RESUMO

PURPOSE: To determine the validity evidence based on the internal structure and relations to other variables and the reliability of an epidemiologic questionnaire for screening older adults with voice disorders. STUDY DESIGN: This is a prospective, nonrandomized, cross-sectional, validation study. METHODS: To assess the validity evidence based on the internal structure, 160 older adults of both sexes, either community-dwelling or institutionalized, completed the "Rastreamento de Alterações Vocais em Idosos" (RAVI; "Screening for Voice Disorders in Older Adults"). The data were analyzed using item-total and interitem correlations, principal component analysis, confirmatory factor analysis, and differential item functioning. For validity evidence based on relations to other variables, measures of concurrent and discriminant validity were calculated according to the self-reported number of factors associated with voice disorders. Reliability was assessed using a test-retest procedure conducted with 121 older adults with the same characteristics as the previous sample. In this stage, the reproducibility, internal consistency, and measurement error of the instrument were analyzed. RESULTS: The RAVI showed adequate validity evidence based on the internal structure and relations to other variables, as well as good reliability. This indicates that the results produced by the instrument are valid and reliable. CONCLUSIONS: The RAVI is a self-reported outcome questionnaire that yields valid and reliable responses for epidemiologic detection of voice disorders in older adults and can be easily administered by any health care provider. Further ongoing studies will assess accuracy measures and cutoff values of the RAVI.


Assuntos
Inquéritos e Questionários , Distúrbios da Voz/diagnóstico , Qualidade da Voz , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Percepção Auditiva , Brasil/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Reprodutibilidade dos Testes , Fatores de Risco , Distúrbios da Voz/epidemiologia , Distúrbios da Voz/fisiopatologia
12.
J Voice ; 30(2): 246.e9-17, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25979792

RESUMO

PURPOSE: To identify the validity evidence based on the content and response processes of the Rastreamento de Alterações Vocais em Idosos (RAVI; "Screening for Voice Disorders in Older Adults"), an epidemiologic screening for voice disorders in older adults. STUDY DESIGN: This is a prospective, nonrandomized, cross-sectional, validation study. METHODS: Criteria for defining the domains and elaborating the questions were established to confirm the validity evidence based on the content. A multidisciplinary committee of 19 experts evaluated the questions, and the relevance and representation of the domains were analyzed using the Content Validity Index for Items (CVI-I) and the Content Validity Index (CVI), respectively. For validity evidence based on the response processes, 40 individuals of both sexes, aged ≥60 years, were stratified by demographic and socioeconomic condition. They responded to the RAVI, made suggestions, and their verbal and nonverbal reactions were observed. RESULTS: The first version of the RAVI consisted of 20 questions related to sensations and perceptions associated with the voice. Although the CVI value of 0.80 was satisfactory, the CVI-I and the suggestions of the expert committee indicated that the scale needed to be reformulated. Consultation with older adults indicated a need for further adjustment. The preliminary version of the RAVI consisted of 16 questions. CONCLUSIONS: The two aspects of validity evidence described in the present study were essential for adapting the questions to better fit the construct of the questionnaire. Other aspects of validity evidence and reliability analysis will be described in part II of this study.


Assuntos
Inquéritos e Questionários , Distúrbios da Voz/diagnóstico , Qualidade da Voz , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Percepção Auditiva , Brasil/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Reprodutibilidade dos Testes , Fatores de Risco , Distúrbios da Voz/epidemiologia , Distúrbios da Voz/fisiopatologia
13.
J Indian Soc Periodontol ; 20(5): 503-508, 2016 Sep-Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29242685

RESUMO

Background: Combating biofilm-dependent oral infections involves the use of synthetic antibiotics, which are often associated with bacterial resistance and adverse effects. As a result, herbs such as cranberry have emerged as an alternative treatment. The aim of this study was to evaluate, through an integrative literature review, the effectiveness of cranberry extract on cultures and biofilms of periodontopathogenic bacteria. Materials and Methods: In vitro and in vivo studies evaluating the action of cranberry extract on the growth, coaggregation and formation of periodontopathogenic bacteria and periodontal biofilm were identified. Searches were carried out in the "Cochrane Library," "MEDLINE," "Web of Science," "Scopus," "LILACS," "Scielo," and "Google Scholar" databases, using the terms: "vaccinium macrocarpon;" "cranberries;" "cranberry;" "biofilms;" "periodontitis;" "chronic periodontitis;" "aggressive periodontitis;" "periodontal diseases;" and "periodont*." Results: a low number of studies evaluating the effectiveness of cranberry extract on periodontal disease were found, and no human studies were identified. In general, the eight studies included in the revision found that the compounds effectively inhibited the formation of a biofilm of Porphyromonas gingivalis and Fusobacterium nucleatum at concentrations equal or superior to 62.5 µg/ml, but did not significantly inhibit bacterial growth or promote the breakdown of preformed biofilm. Conclusions: while most of the studies presented certain methodological limitations, they did identify an inhibiting effect of cranberry on periodontal bacteria. These results serve as support for the development of further studies evaluating the most effective vehicle and ideal concentration that can be used without causing adverse effects on oral tissues.

14.
Int Dent J ; 65(6): 331-7, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26397722

RESUMO

OBJECTIVE: The aim of the present study was to evaluate the influence of oral conditions in preschool children and associated factors on work absenteeism experienced by parents or guardians. METHODS: A preschool-based, cross-sectional study was conducted of 837 children, 3-5 years of age, in Campina Grande, Brazil. Parents or guardians answered the Brazilian version of the Early Childhood Oral Health Impact Scale. The item 'taken time off work' was the dependent variable. Questionnaires addressing sociodemographic variables, history of toothache and health perceptions (general and oral) were also administered. Clinical examinations for dental caries and traumatic dental injury (TDI) were performed by three dentists who had undergone training and calibration exercises. Cohen's kappa (κ) was 0.83-0.88 for interexaminer agreement and 0.85-0.90 for intra-examiner agreement. Descriptive, analytical statistics were conducted, followed by logistic regression for complex samples (α = 5%). RESULTS: The prevalence of parents' or guardians' work absenteeism because of the oral conditions of their children was 9.2%. The following variables were significantly associated with work absenteeism: mother's low schooling [odds ratio (OR) = 2.31; 95% confidence interval (95% CI): 1.31-4.07]; history of toothache (OR = 6.33; 95% CI: 3.18-12.61); and avulsion or luxation types of TDI (OR = 8.54; 95% CI: 1.80-40.53). CONCLUSION: Other oral conditions that do not generally cause pain, such as dental caries with a low degree of severity or inactive dental caries and uncomplicated TDI, were not associated with parents' or guardians' work absenteeism of preschool children. It is concluded that toothache, avulsion, luxation and a low degree of mother's schooling are associated with work absenteeism.


Assuntos
Absenteísmo , Saúde Bucal , Pais , Trabalho , Fatores Etários , Atitude Frente a Saúde , Brasil/epidemiologia , Saúde da Criança , Pré-Escolar , Estudos Transversais , Cárie Dentária/epidemiologia , Escolaridade , Saúde da Família , Feminino , Nível de Saúde , Humanos , Renda , Masculino , Pais/psicologia , Qualidade de Vida , Avulsão Dentária/epidemiologia , Traumatismos Dentários/epidemiologia , Odontalgia/epidemiologia
15.
PLoS One ; 10(2): e0116799, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25689279

RESUMO

Oral mucositis (OM) is a common complication of treatments for head and neck cancer, particularly radiotherapy with or without chemotherapy. OM is characterised by oral erythema, ulceration, and pain. The aim of this study was to evaluate the effect of azilsartan (AZT), an angiotensin II receptor antagonist, on 5-fluorouracil (5-FU)-induced oral mucositis (OM) in Syrian hamsters. OM was induced by the intraperitoneal administration of 5-FU on experimental days 1 (60 mg/Kg) and 2 (40 mg/Kg). Animals were pretreated with oral AZT (1, 5, or 10 mg/kg) or vehicle 30 min before 5-FU injection and daily until day 10. Experimental treatment protocols were approved by the Animal Ethics Committee Use/CEUA (Number 28/2012) of the UFRN. Macroscopic analysis and cheek pouch samples were removed for histopathologic analysis. Myeloperoxidase (MPO), Malonyldialdehyde (MDA), interleukin-1 beta (IL-1ß), interleukin-10 (IL-10), and tumour necrosis factor-alpha (TNF-α) were analysed by Enzyme Linked Immuno Sorbent Assay (ELISA). Vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), keratinocyte growth factor (KGF), and transforming growth factor (TGF)-α were measured by immunohistochemistry. Analysis of variance followed by Bonferroni's test was used to calculate the means of intergroup differences (p ≤ 0.05). Treatment with 1 mg/kg AZT reduced levels MPO (p<0.01), MDA (p<0.5) and histological inflammatory cell infiltration, and increased the presence of granulation tissue. AZT treatment at 1 mg/kg reduced the TNF-α (p<0.05) and IL-1ß (p<0.05) levels, increased the cheek pouch levels of IL-10 (p<0.01), and upregulated VEGF, FGF, KGF, and TGF-α. Administration of AZT at higher doses (5 and 10 mg/kg) did not significantly reverse the OM. AZT at a dose of 1 mg/kg prevented the mucosal damage and inflammation associated with 5-FU-induced OM, increasing granulation and tissue repair.


Assuntos
Citocinas/metabolismo , Peptídeos e Proteínas de Sinalização Intercelular/metabolismo , Estomatite/metabolismo , Animais , Bacteriemia/metabolismo , Benzimidazóis/efeitos adversos , Cricetinae , Modelos Animais de Doenças , Fator 7 de Crescimento de Fibroblastos/metabolismo , Fatores de Crescimento de Fibroblastos/metabolismo , Interleucina-10/metabolismo , Interleucina-1beta/metabolismo , Leucócitos/metabolismo , Masculino , Oxidiazóis/efeitos adversos , Peroxidase/metabolismo , Estomatite/induzido quimicamente , Estomatite/patologia , Fator de Crescimento Transformador alfa/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Regulação para Cima , Fator A de Crescimento do Endotélio Vascular/metabolismo
16.
Appl Ergon ; 47: 93-8, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25479978

RESUMO

The aim of the present study was to assess the relationship between physical load and musculoskeletal complaints in dentistry and to analyze the prevalence and severity of such complaints in nine anatomical regions using a cross-sectional study of 387 dentists from Natal, Brazil. The highest prevalence of complaints was related to the lower back (58.4%) and the lowest prevalence was found in the elbow (10.3%). In general, symptoms were classified as mild because they did not cause absence due to illness. Pain complaints were associated with the following characteristics: awkward posture at work; prolonged standing or sitting; strenuous position of the upper limbs; excessive tightening of the hands during clinical treatment; and the use of vibrating tools. The results of the present study suggest a high prevalence of musculoskeletal complaints in dentists that are significantly associated with variables related to their physical workload.


Assuntos
Odontologia , Dor Musculoesquelética/epidemiologia , Doenças Profissionais/epidemiologia , Postura , Carga de Trabalho , Adulto , Tornozelo , Brasil/epidemiologia , Estudos Transversais , Cotovelo , Feminino , Quadril , Humanos , Dor Lombar/epidemiologia , Masculino , Pessoa de Meia-Idade , Cervicalgia/epidemiologia , Prevalência , Fatores de Risco , Índice de Gravidade de Doença , Dor de Ombro/epidemiologia , Inquéritos e Questionários , Vibração , Suporte de Carga/fisiologia
17.
Eur Arch Otorhinolaryngol ; 272(10): 2601-9, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25149291

RESUMO

Voice disorders can occur in the elderly as a result of natural anatomical and physiological changes or greater exposure to pathological conditions in the aging, affecting communication and quality of life. Nevertheless, data about the prevalence of voice disorders in this phase of life are not well known in a population-based perspective. The aim of the present systematic review was to identify the prevalence of vocal disorders in persons aged 60 years or more in population-based studies. A systematic review was undertaken in eleven electronic databases based on preferred reporting items for systematic reviews and meta-analysis statement (PRISMA) criteria. The methodological quality of the studies was analyzed with strengthening the reporting of observational studies in epidemiology (STROBE) directives. The search was conducted independently by two researchers. Four articles satisfied the criteria of eligibility. The prevalence of vocal disorders in the general population aged 60 years or more ranged from 4.8 to 29.1%. The studies were different in terms of the methodological procedures and the STROBE directives were not completely satisfied by any of the articles selected. The prevalence of vocal disorders in the general elderly population ranged from low to moderate in population-based studies. The methodological discrepancies of the studies compromised the reliability of the estimated data. Upgrading the methodological quality of studies and designing a short, valid and easy-to-use functional voice-related instrument are urgently required in health surveys to determine the prevalence of vocal disorders among elderly individuals.


Assuntos
Envelhecimento , Vigilância da População , Distúrbios da Voz/epidemiologia , Fatores Etários , Idoso , Saúde Global , Humanos , Prevalência , Reprodutibilidade dos Testes
18.
Cien Saude Colet ; 19(1): 105-13, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24473608

RESUMO

The scope of this study was to correlate toothache with social and economic conditions, access to oral health facilities and the lifestyle of adolescents in Sobral in the state of Ceará. It was conducted as a cross-sectional analytical study with a sample composed of 688 adolescents. The prevalence of toothache in the study group was 31.8%. A chi-square test of association was performed to measure the relationship between independent variables and toothache, estimating the prevalence ratio by Poisson regression. The factors that demonstrated the closest relationship with toothache were cavity severity, the reason for dental treatment being related to urgency, frequency of dental appointments and the distribution of toothbrushes at school. It was observed that the high prevalence of dental pain in adolescents is directly linked to the access conditions, as well as the characteristics of the actions developed by the health services. Just as there is a need for the deployment of services related to health promotion, based on equity and integration, it is necessary to introduce emergency services to intervene not just to curtail crippling pain, but also as a mechanism to stimulate the development of procedures for the prevention of oral diseases.


Assuntos
Odontalgia/epidemiologia , Adolescente , Brasil , Criança , Estudos Transversais , Inquéritos de Saúde Bucal , Feminino , Acesso aos Serviços de Saúde , Humanos , Estilo de Vida , Masculino , Prevalência , Fatores Socioeconômicos
19.
Cien Saude Colet ; 18(12): 3495-506, 2013 Dec.
Artigo em Português | MEDLINE | ID: mdl-24263866

RESUMO

From a critical analysis of experiments in the use of screening tools for functional loss in the elderly, it was observed that the main motivation to develop and implement a screening instrument is to improve health care for the frail elderly or those at risk of functional loss and repeated hospital admissions. The instruments are preferably short questionnaires with no more than 16 self-reported questions. The main intervention performed after screening was monitoring the elderly by a specialized nursing service that, when necessary, referring them to the medical service. The results of this approach included the reduction of functional loss, hospital admissions, deaths, lower health expenses and greater consumer satisfaction.


Assuntos
Atividades Cotidianas , Avaliação Geriátrica , Serviços de Saúde para Idosos/organização & administração , Idoso , Humanos , Medição de Risco , Inquéritos e Questionários
20.
Arch Gerontol Geriatr ; 57(3): 389-97, 2013 Nov-Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23773366

RESUMO

The aim of the present study was to analyze the relationship between oral health conditions and socio-demographic factors in an elderly population from Macaíba/RN (Brazil). A questionnaire was used to characterize the socio-demographic profiles and a clinical examination was performed to assess oral health conditions such as tooth decay, gum disease, use of dental prosthesis, need for dental prosthesis and soft tissue injuries. The technique of random sampling by conglomerates was used, taken from randomly selected census drafts, with a total sample of 441 individuals. The prevalence of edentulism, bleeding and dental calculus was 50.8%, 27.2% and 32%, respectively, excluding all sextants in 59% of the elderly. Data analysis was conducted using the chi-squared test with the level of significance set at 5%. Prior to association tests, the dependant variables were submitted to principal component analysis. Four factors were extracted to represent the oral health conditions of elderly individuals. A statistically significant association was found between the following variables: gender and the presence of a caregiver with gum disease; age, residence area, presence of a caregiver and household density with need for dental prosthesis; and household density with soft tissue injuries. Therefore, precarious oral health conditions were found among the elderly and associations were found between these conditions and the socio-demographic factors, particularly gender, age and residence area. The results obtained demonstrated the need for improved oral health conditions in the elderly. The study of these conditions, allied to socio-demographic factors, is important in terms of both dental care and public policy planning related to these individuals.


Assuntos
Saúde Bucal/estatística & dados numéricos , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Índice CPO , Escolaridade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Amostragem , Fatores Sexuais , Fatores Socioeconômicos
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