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1.
J Nutr Biochem ; 53: 9-19, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29175142

RESUMO

The "first hit" to atherogenesis is driven by toll-like receptor 4, endoplasmic reticulum stress and ultimately metabolic dysfunction. In this study, we hypothesized that a flaxseed oil-enriched diet (FS) abolishes these inflammatory signaling pathway and restore metabolic homeostasis by activating the fatty acid receptor GPR120 in aorta of obese mice. Glucose homeostasis was assessed by GTT and ITT; lipidomics was performed using a Hybrid Ion Trap-Orbitrap Mass Spectrometer; serum lipids were measured using colorimetric assays; GPR120 and infiltrating macrophages were analyzed by immunofluorescence; protein immunoprecipitation and gene expression were evaluated by Western blot and RT-PCR, respectively. There were no differences in body weight and food intake between the groups from both strains (Swiss and LDLr-KO mice). GTT and cholesterol levels were improved by FS in both mice models. Lipidomics showed an increase in ω3 (C18:3) content, meanwhile stearic acid (C18:0) was not detected in endothelial tissue in response to FS. Moreover, FS markedly decreased pro-inflammatory (IL-1ß, TNF-α, pIκBα, pIKKß) and unfolded protein response markers (ATF6 and GRP78) in aorta. In Swiss mice, GPR120 was partially involved in the ω3-mediated anti-inflammatory actions, disrupting TLR4 pathway, but not in LDLr-KO mice. Partial replacement of dietary saturated by unsaturated ω3 fatty acids contributes to inhibition of cardiovascular risk markers, pro-inflammatory cytokines and ER stress sensors and effectors in the aorta. However, downregulation of inflammation is not mediated by arterial GPR120 activation.


Assuntos
Aortite/prevenção & controle , Estresse do Retículo Endoplasmático/efeitos dos fármacos , Óleo de Semente do Linho/farmacologia , Receptores Acoplados a Proteínas-G/metabolismo , Animais , Aortite/metabolismo , Modelos Animais de Doenças , Dislipidemias/dietoterapia , Dislipidemias/fisiopatologia , Ácidos Graxos Ômega-3/farmacologia , Óleo de Semente do Linho/química , Lipídeos/sangue , Macrófagos/efeitos dos fármacos , Macrófagos/metabolismo , Masculino , Camundongos , Camundongos Knockout , Obesidade/dietoterapia , Obesidade/fisiopatologia , Substâncias Protetoras/farmacologia , Receptores de LDL/genética
2.
Eye (Lond) ; 27(1): 92-9, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23154488

RESUMO

PURPOSE: Our aim was to evaluate the potential effect of imatinib mesylate (IM), a small molecule that specifically inhibits the tyrosine quinase receptors, on the proliferation and invasive abilities of two human retinoblastoma (Rb) cell lines. Furthermore, the ability of IM to radiosensitize Rb cells was evaluated. The potential targets of IM (C-kit, PDGRF-α and -ß, and c-Abl) were also investigated in these cell lines. METHODS: Two human Rb cell lines (WERI-RB-1 and Y79) were cultured under normal growth conditions. An MTT-based proliferation assay and a Matrigel invasion assay were performed with and without exposure to 10 µM of IM. The cells were also irradiated with graded dosages of 0, 2, 4, 6, 8, and 10 Gy with and without IM and their proliferations rates were analyzed. Western blot and immunocytochemical analysis of cytospins were performed to evaluate the expression of C-kit, PDGRF-α and -ß, and c-Abl. RESULTS: When IM was added to both cell lines a statistically significant (P<0.05) reduction in proliferation and invasive ability were observed. Exposure to IM also significantly increased the radiosensitivity of both Rb cell lines. The c-Abl expression was strongly positive, PDGRF-α and -ß expression were also positive but the C-kit expression was negative in both cell lines. CONCLUSIONS: These results indicate that Gleevec may be useful as an adjuvant treatment in Rb patients, specially those considered for radiation therapy.


Assuntos
Antineoplásicos/farmacologia , Benzamidas/farmacologia , Linhagem Celular Tumoral/efeitos dos fármacos , Piperazinas/farmacologia , Inibidores de Proteínas Quinases/farmacologia , Pirimidinas/farmacologia , Tolerância a Radiação/efeitos dos fármacos , Neoplasias da Retina/tratamento farmacológico , Retinoblastoma/tratamento farmacológico , Western Blotting , Linhagem Celular Tumoral/metabolismo , Linhagem Celular Tumoral/efeitos da radiação , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta à Radiação , Humanos , Mesilato de Imatinib , Imuno-Histoquímica , Invasividade Neoplásica , Proteínas Proto-Oncogênicas c-kit/metabolismo , Receptor alfa de Fator de Crescimento Derivado de Plaquetas/metabolismo , Neoplasias da Retina/metabolismo , Retinoblastoma/metabolismo
3.
Trop Med Int Health ; 6(3): 219-26, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11299039

RESUMO

We compared saline (S) and sodium dodecyl sulphate (SDS) extracts from Taenia solium (homologous species - HO) and Taenia crassiceps (heterologous species - HE) metacestodes in order to detect IgG by ELISA and immunoblot assay (IBA) in cerebrospinal fluid (CSF) for the diagnosis of human neurocysticercosis (NC). CSF samples were obtained from 93 patients. Of these, 40 had NC, five had a diagnosis of probable NC, nine had central nervous system schistosomiasis or strongyloidiasis and 39 had other neurological alterations. Samples were analysed by ELISA and the results were compared with IBA in all samples with confirmed and probable NC diagnosis, in all samples with other central nervous system parasitic infection, and in 10 of those with another neurological alterations. ELISA sensitivity was 100%, 85%, 95% and 87.5% for the S-HO, S-HE, SDS-HO and SDS-HE extracts, respectively, and ELISA specificity was 100% for S-HO, S-HE, SDS-HO extracts and 97.9% for SDS-HE antigen. Immunodominant peptides detected by IBA were, by decreasing percentage of recognition: 64-68 and 45 kDa for S-HO; 108-114, 92-95, 64-68, 83 and 88 kDa for S-HE; 64-68, 108-114, 77 and 86 kDa for SDS-HO; and 108-114, 88 and 92-95 kDa for SDS-HE. Overall the homologous antigenic extracts showed higher sensitivity than the heterologous extracts in the diagnosis of NC in CSF samples. The heterologous extracts contained most of the immunodominant peptides presented in the homologous extracts, which are recognized by IgG antibodies in CSF samples.


Assuntos
Anticorpos Anti-Helmínticos/líquido cefalorraquidiano , Imunoglobulina G/líquido cefalorraquidiano , Neurocisticercose/diagnóstico , Taenia/imunologia , Animais , Ensaio de Imunoadsorção Enzimática , Humanos , Immunoblotting , Peso Molecular , Testes Sorológicos , Cloreto de Sódio/farmacologia , Dodecilsulfato de Sódio/farmacologia
4.
Rev Bras Enferm ; 54(3): 435-45, 2001.
Artigo em Português | MEDLINE | ID: mdl-12221942

RESUMO

The present study is the result of an experience in the hospital Correia Picanço in Recife, Pernambuco Federal State, a reference hospital for HIV patients. The objective of this investigation is to supply the discrepancy of information on elderly carriers of HIV. This is a quantitative, transversal and retrospective research. A diagram form was used to organize the data collected from 46 medical records. Results showed that there was an increase on the number of women, especially married women, heterosexuals, and elderly infected by HIV. The study also showed an increase on the number of infections through sexual contact and the predominance of carriers who were undereducated. It was also observed that the medical records were incomplete. The conclusion was that preventive education programs have to be elaborated in order to reach the population in general, including the elderly.


Assuntos
Infecções por HIV/epidemiologia , Síndrome de Imunodeficiência Adquirida/epidemiologia , Distribuição por Idade , Idoso , Brasil/epidemiologia , Feminino , Infecções por HIV/transmissão , Humanos , Masculino , Pessoa de Meia-Idade , Distribuição por Sexo , Fatores Socioeconômicos
5.
Trop Med Int Health ; 5(6): 443-9, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10929145

RESUMO

A comparative study of total saline extract (SE) and cyst vesicular fluid (VF) of Taenia solium metacestodes by ELISA and Western blotting assay (WB) tests was conducted to detect IgG in sera for diagnosis of human cysticercosis. Sera were obtained and analysed by ELISA in 1 : 20 and 1 : 100 dilutions from 208 individuals: 22 confirmed neurocysticercosis (NC) (group 1), 101 suspected NC (group 2), 55 with various intestinal parasitosis (group 3) and 30 healthy individuals (group 4). The WB test was carried out on SE and VF extracts with and without reducing agent, 2-beta-mercaptoethanol (2-ME) in 20 sera of each group. WB using extracts without 2-ME and ELISA at 1 : 100 dilution were compared in 20 sera from each group; sensitivity and specificity were calculated using samples from groups 1, 3 and 4. By ELISA, in the 1 : 100 sera dilution reactivity was reduced for both antigens without changes in the sensitivity of the test. By WB, antigens treated with 2-ME demonstrated low specificity. For SE and VF antigens, the proteins of 24, 39-42, 47-52, 56, 64-68, 126-155 kDa and 18, 24, 26-28, 32-36, 47-52, 75 kDa, respectively, were considered immunodominant markers, with high indices of specificity, suggesting a profile for NC patients. However, as the sensitivity was found to be low, it might still not be a definitive test for NC when used alone. These data suggest WB as an indicative test to determine exposure to T. solium. ELISA and WB together may supply reliable results for the diagnosis of human cysticercosis, since appropriate purified antigens are not available yet.


Assuntos
Anticorpos Anti-Helmínticos/sangue , Imunoglobulina G/sangue , Neurocisticercose/diagnóstico , Taenia/imunologia , Adolescente , Adulto , Idoso , Animais , Western Blotting/normas , Criança , Pré-Escolar , Eletroforese em Gel de Poliacrilamida , Ensaio de Imunoadsorção Enzimática/normas , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Sensibilidade e Especificidade , Taenia/isolamento & purificação
6.
Rev Assoc Med Bras (1992) ; 44(2): 87-93, 1998.
Artigo em Português | MEDLINE | ID: mdl-9699324

RESUMO

OBJECTIVE: To evaluate the utility of kidney aspiration cytology in the sequential monitorization of acute rejection in renal transplant patients. PATIENTS AND METHODS: Thirty patients were submitted to 376 aspirations. The clinical diagnoses were independently established. RESULTS: The representativity of the samples reached 82.7%. The total corrected increment index and the number of immunoactivated cells were higher during acute rejection as compared to normal allograft function, acute tubular necrosis, and cyclosporine nephrotoxicity. The parameters to the diagnosis of acute rejection were sensitivity: 71.8%, specificity: 87.3%, positive predictive value: 50.9%, negative predictive value: 94.9% and accuracy 84.9%. The false positive results were mainly related to cytomegalovirus infection or to the administration of OKT3. In 10 out of 11 false negative results incipient immunoactivation was present alerting to the possibility of acute rejection. CONCLUSIONS: Kidney aspiration cytology is a useful tool for the sequential monitorization of acute rejection in renal transplant patients. The best results are reached when the results of aspiration cytology are analyzed with the clinical data.


Assuntos
Doença Aguda , Biópsia por Agulha/métodos , Rejeição de Enxerto/patologia , Transplante de Rim/patologia , Técnicas Citológicas , Rejeição de Enxerto/tratamento farmacológico , Rejeição de Enxerto/epidemiologia , Humanos , Imunossupressores/uso terapêutico , Incidência , Transplante de Rim/imunologia , Monitorização Fisiológica , Muromonab-CD3/uso terapêutico , Estatísticas não Paramétricas
7.
Rev Gaucha Enferm ; 18(2): 94-103, 1997 Jul.
Artigo em Português | MEDLINE | ID: mdl-9633445

RESUMO

This paper is an historical review of the health policy in Brazil. Ranged since the arrival of the real portuguese family to Brazil until nowadays. The review intent to contextualize present facts based on historical, social and political facts for the needed foundation to give best comprehension of the ways in which is organizing the health policy in Brazil.


Assuntos
Política de Saúde/história , Brasil , Governo , História do Século XIX , História do Século XX , Humanos , Sistemas Políticos/história , Política
8.
J Am Soc Nephrol ; 8(3): 361-7, 1997 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9071704

RESUMO

Whole-kidney function and glomerular hemodynamics were evaluated after acute (50 mg/kg, iv, in bolus) and short-term chronic (50 mg mg/kg, ip, 5 days) acyclovir (ACV) and short-term chronic ganciclovir (Gan; 30 mg/kg, ip, 5 days) treatment in envolemic Munich-Wistar rats. The evaluation of whole-kidney function of the ACV groups showed a significant reduction in total GFR (0.96 +/- 0.10 to 0.28 +/- 0.02 mL/min in the acute group, P < 0.05, and 1.04 +/- 0.09 to 0.33 +/- 0.04 mL/min in the chronic group, P < 0.05) with a marked increase in total renal vascular resistance (TRVR) (33 +/- 5 to 122 +/- 26 mm Hg.min/mL in the acute group and 28 +/- 3 to 74 +/- 18 mm Hg.min/mL in the chronic group, P < 0.05) and a reduction in RPF (2.29 +/- 0.25 to 0.81 +/- 0.15 mL/min in the acute group and 2.57 +/- 0.36 to 1.30 +/- 0.40 mL/min in the chronic group, P < 0.05). Conversely, urinary flow (V') was unchanged (3.6 +/- 0.4 to 3.6 +/- 0.2 microL/min in the acute group) or elevated (3.7 +/- 0.6 to 6.6 +/- 1.4 microL/min in the chronic group, P < 0.05). The evaluation of glomerular hemodynamics after ACV treatment showed a reduction in single-nephron GFR (SNGFR) (46.4 +/- 5.3 to 26.2 +/- 3.4 nL/min in the acute group and 38.7 +/- 5.7 to 21.1 +/- 5.7 nL/min in the chronic group, P < 0.05), a significant elevation in total arteriolar resistance (RT) (2.90 +/- 0.44 to 4.94 +/- 0.77 x 10(10) dyn.s.cm-5 in the acute group and 3.72 +/- 0.45 to 9.00 +/- 2.40 x 10(10) dyn.s.cm-5 in the chronic group, P < 0.05) and a severe reduction in glomerular plasma flow rate (QA) (152.6 +/- 29.5 to 103.8 +/- 27.8 nL/min in the acute group and 149.1 +/- 29.8 to 68.5 +/- 10.0 nL/min in the chronic group, P < 0.05). However, the glomerular ultrafiltration coefficient, Kf, was changed only in the chronic group (0.1002 +/- 0.0165 to 0.0499 +/- 0.0090 nL/(s.mm Hg), P < 0.05). After Gan treatment, no changes were observed in GFR (1.04 +/- 0.09 to 0.96 +/- 0.08 mL/min, with the maintenance of RPF (2.57 +/- 0.36 to 2.66 +/- 0.34 mL/min) and a nonsignificant reduction in TRVR (28 +/- 3 to 20 +/- 3 mm Hg.min/mL. The short-term Gan treatment also showed a different pattern in glomerular hemodynamics by inducing an elevation in SNGFR (38.7 +/- 5.7 to 50.3 +/- 2.8 nL/min, P < 0.05) with no changes in QA (150 +/- 30 to 135 +/- 22 nL/min) and a mild vasodilation, RT (3.7 +/- 0.5 to 2.7 +/- 0.3 x 10(10) dyn.s.cm-5, P < 0.05) associated with an increment in Kf (0.1002 +/- 0.0165 to 0.2400 +/- 0.0700 nL/(s.mm Hg), P < 0.05). Thus, ACV induced acute renal failure by reducing GFR and SNGFR by an increase in TRVR and RT with a reduction in RPF and QA. Also, after short-term treatment with ACV, a reduction in Kf led to a reduction of SNGFR. On the other hand, Gan treatment did not induce acute renal failure by the adopted techniques.


Assuntos
Aciclovir/envenenamento , Antivirais/envenenamento , Ganciclovir/envenenamento , Glomérulos Renais/irrigação sanguínea , Rim/efeitos dos fármacos , Lesão Renal Aguda/induzido quimicamente , Animais , Taxa de Filtração Glomerular/efeitos dos fármacos , Hemodinâmica/efeitos dos fármacos , Rim/fisiopatologia , Masculino , Ratos , Ratos Wistar , Circulação Renal/efeitos dos fármacos , Resistência Vascular/efeitos dos fármacos
10.
Nephrol Dial Transplant ; 10(12): 2306-9, 1995 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-8808230

RESUMO

BACKGROUND: Although it has been used as a diagnostic tool in many renal transplant centres the reproducibility of fine-needle aspiration biopsy (FNAB) has not been critically evaluated. METHODS: In the present study material sequentially obtained from 15 patients (177 aspirations) over a 3-month period following renal transplantation was evaluated by two independent observers. Intraobserver reproducibility was studied through the analysis of two evaluations by observer 1 performed 8 months apart. Interobserver reproducibility was calculated comparing the second evaluation of observer 1 with the evaluation of observer 2. All evaluations were performed blindly. Slides and protocols of individual patients were chronologically arranged and thus interpreted. Representation, total corrected increment (TCI), accuracy, and the percent agreement for the diagnosis of acute rejection were evaluated. RESULTS: No intraobserver statistically significant differences were observed. Differences observed in interobserver evaluation of TCI either during, or out of acute rejection episodes, well as the representative quality of the sample and accuracy, were not statistically significant. The percent of agreement for the presence or absence of acute rejection was 77.5% for the intraobserver comparison and 76.7% for the interobserver evaluation. Both values showing either a non-significant value for the difference or a statistical significance for the concordance. CONCLUSION: We concluded that FNAB is an accurate method with fairly good intra- and interobserver reproducibility for the diagnosis of acute rejection of renal allografts.


Assuntos
Rejeição de Enxerto/patologia , Transplante de Rim/patologia , Transplante Homólogo/patologia , Doença Aguda , Biópsia por Agulha , Humanos , Variações Dependentes do Observador , Reprodutibilidade dos Testes
11.
Arq Neuropsiquiatr ; 52(1): 82-6, 1994 Mar.
Artigo em Português | MEDLINE | ID: mdl-8002815

RESUMO

The involvement of central nervous system in paracoccidiodomycosis has rarely been described, with an incidence rate varying from 9.99% to 27.27%. There are two basic forms of clinical presentation: meningeal and tumor-like (abscesses, granulomas, nodules, and cysts). The Paracoccidioides brasiliensis is preferentially described in cerebral hemispheres, cerebellum, medulla oblonga and meninges, and exceptionally in the spinal cord. The authors present a case of paracoccidioidomycosis which diagnosis was achieved by microscopic examination of material from oral lesions and specific serology. The patient presented clinical signs of spinal cord involvement confirmed by lesions found in magnetic resonance imaging. They emphasize the inedit therapeutic response to a new antifungal agent (fluconazole) used for the first time in this kind of clinical manifestation, and the excellent prognosis when diagnosis is promptly made.


Assuntos
Mielite Transversa/etiologia , Paracoccidioidomicose/complicações , Fluconazol/administração & dosagem , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Mielite Transversa/diagnóstico , Mielite Transversa/tratamento farmacológico , Paracoccidioides/isolamento & purificação , Paracoccidioidomicose/diagnóstico , Paracoccidioidomicose/tratamento farmacológico
12.
Rev Saude Publica ; 25(2): 159-62, 1991 Apr.
Artigo em Português | MEDLINE | ID: mdl-1784974

RESUMO

Psychosocial aspects which arise with regard to people directly or indirectly involved with AIDS: patients, relatives and professional staff, are studied. The results show that the population assisted in the Ribeirão Preto region is predominantly young, male and drug-addicted. The patients with "positive" results show reactions similar to those described by Kluber-Ross (1977) for terminal patients. The behavior observed in relatives forms a continuum which varies from the negation of the illness to the overprotection of the patient. For the professionals, perplexity is the most common reaction when they face a population which is different from that with which they are used to dealing. Finally, the data acquired indicate that the psychologist can help the professionals to deal with the reactions of the patients by integrating them into their organic and emotional aspects.


Assuntos
Síndrome de Imunodeficiência Adquirida/psicologia , Atitude do Pessoal de Saúde , Família , Feminino , Humanos , Masculino
14.
AMB Rev Assoc Med Bras ; 35(5): 167-70, 1989.
Artigo em Português | MEDLINE | ID: mdl-2486411

RESUMO

In order to analyse the etiology of recurrent hematuria in childhood, we studied 250 children, referred to our Service (age: 6 mo-17 ys; 102 female and 148 male). They were submitted to the following protocol: urine analyses, uroculture, serum total and fraction complement, electrophoresis of hemoglobin, serum creatinine, BUN, 24h urinary calcium, uric acid and protein, oral calcium load test in children with hypercalciuria (UCa greater than 4mg/kg/day). Radiological evaluation and renal percutaneous biopsy was performed when necessary. The following diagnostic distribution was obtained: Alport syndrome, 19; Berger disease, 15; other glomerulopathies, 45; hypercalciuria, 67; uric acid hyperexcretion, 10; nephrolithiasis, 27; urinary tract infection, 14; renal malformation, 8; no diagnosis, 43. Based in these results, we conclude that appropriate investigation on recurrent hematuria, leads to determination of etiology in over 80% of cases.


Assuntos
Hematúria/etiologia , Adolescente , Cálcio/urina , Criança , Pré-Escolar , Eritrócitos/ultraestrutura , Feminino , Hematúria/patologia , Humanos , Lactente , Cálculos Renais/complicações , Masculino , Microscopia de Contraste de Fase , Ácido Úrico/urina
16.
Clin Chem ; 31(5): 767-8, 1985 May.
Artigo em Inglês | MEDLINE | ID: mdl-3886197

RESUMO

We used an enzyme immunoassay to determine the normal reference intervals for thyroxin, triiodothyronine, and thyrotropin in groups of children, ranging from newborns to 15-year-olds. Results compared well with those by radioimmunoassay. There were no substantial differences between plasma and serum samples for thyroxin and triiodothyronine, but thyrotropin concentrations differed significantly (p less than 0.05, n = 20 each).


Assuntos
Técnicas Imunoenzimáticas , Glândula Tireoide/fisiologia , Adolescente , Fenômenos Químicos , Química , Criança , Pré-Escolar , Feminino , Sangue Fetal/análise , Humanos , Lactente , Masculino , Testes de Função Tireóidea , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangue
17.
Otolaryngology ; 86(6 Pt 1): ORL-924-9, 1978.
Artigo em Inglês | MEDLINE | ID: mdl-113751

RESUMO

A surgical procedure is described that minimizes the lifting of the hairline in rhytidectomy by locating most of the incision inside the hair. Traction of the skin is directed at producing a soft, rounded contour. The author reports good results on 30 patients in two years' time. Appropriateness of rhytidectomy depends on psychologic factors and on biologic rather than chronologic age. Operation under general anesthesia is preferred and should be confined to a simple procedure. However, blepharoplasty, rhinoplasty, and mentoplasty are often performed at the same time. Forehead lifting is a desirable associated procedure in which the incisions can be joined. Cutting of the muscle fibers is preferred to resection of the frontal corrugator. Minilifting to obtain Oriental slant eyes is considered a wasted effort.


Assuntos
Face/cirurgia , Cirurgia Plástica/métodos , Anestesia Geral , Anestesia Local , Dermabrasão , Procedimentos Cirúrgicos Dermatológicos , Estética , Feminino , Testa , Humanos , Masculino , Psicologia
18.
Otolaryngology ; 86(5): ORL-685-8, 1978.
Artigo em Inglês | MEDLINE | ID: mdl-226917

RESUMO

A malignant fibrous histiocytoma from the maxillary sinus of a 51-year-old woman was treated surgically with adjuvant chemotherapy and radiation. The maxillary sinus is an unusual site for this rare and controversial neoplasm, as a review of the literature shows.


Assuntos
Histiocitoma Fibroso Benigno/patologia , Seio Maxilar/patologia , Neoplasias dos Seios Paranasais/patologia , Diagnóstico Diferencial , Feminino , Histiocitoma Fibroso Benigno/terapia , Humanos , Pessoa de Meia-Idade , Neoplasias dos Seios Paranasais/terapia
19.
Artigo em Inglês | MEDLINE | ID: mdl-335616

RESUMO

A surgical procedure is described which corrects the ansiform ear by repositioning and reconstructing the anthelix and the anterior crus with the formation of the triangular fossa. This corrects the scaphoconchal angle and improves the cephaloauricular angle, overcoming the problem of prominent ears. Correction in early childhood is recommended in order to avoid personality problems that may result from the deformity, particularly in boys. The technique employed yields important advantages: (1) prolonged use of the helmet-type of surgical dressing is unnecessary; (2) scars are less conspicuous; (3) the outcome is attractive and normal; (4) bleeding and inflammatory complications are avoided; and (5) recurrence of the malformation is unlikely.


Assuntos
Orelha Externa/anormalidades , Cirurgia Plástica/métodos , Cartilagem/cirurgia , Pré-Escolar , Orelha Externa/cirurgia , Humanos , Masculino , Técnicas de Sutura
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