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Molecules ; 26(13)2021 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-34279398


The aim of this study was to compare the influence of the extraction method, chemical composition, antimicrobial effects, antioxidant activity, and cytotoxicity on human cells of the non-polar extracts of grape (Vitis labrusca) and blackberry (Rubus fruticosus) seeds. The Soxhlet (Sox), Bligh-Dyer (BD), and ultrasound (US) methods were used for extractions. For blackberry non-polar seed extract, extraction via the BD method showed the highest mean values of total phenolic content (TPC), expressed in milligrams of gallic acid equivalent per 100 mL of non-polar seed extracts (102.37 mg GAE/100 mL), and higher antioxidant activity in relation to the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, expressed in milligrams of gallic acid equivalent per 100 mL of non-polar seed extracts (11.50 mg AAE/100 mL), if compared with the Sox and US extractions. Similar results were obtained for the non-polar grape seed extracts, where BD extraction obtained the highest values for TPC (28.61 mg GAE/100 mL) and DPPH (35.36 mg AAE/100 mL). The type of extraction method had an impact on the composition of fatty acids. Only the non-polar blackberry and grape seed extracts obtained via the Sox method showed some in vitro inhibitory effect against Escherichia coli (IAL 2064) and Staphylococcus aureus (ATCC 13565). Regardless of the extraction method used, the non-polar blackberry and grape seed extracts did not decrease the cell viability (IC50 >1000 µg/mL) of cancer and normal cell lines, thus indicating the relative safety of the extracts. All the seed extracts decreased the generation of reactive oxygen species in the cell lines. Blackberry and grape seed lipid fractions can be utilized as antioxidants, and the extraction methods used cause significant changes in relation to their bioactivity and chemical composition.

Anti-Infecciosos/química , Antioxidantes/química , Extrato de Sementes de Uva/química , Rubus/química , Anti-Infecciosos/farmacologia , Anti-Infecciosos/toxicidade , Antioxidantes/farmacologia , Antioxidantes/toxicidade , Escherichia coli/efeitos dos fármacos , Ácidos Graxos/análise , Flavonoides/análise , Extrato de Sementes de Uva/farmacologia , Staphylococcus aureus/efeitos dos fármacos
Molecules ; 24(21)2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31731548


The circular economy is an umbrella concept that applies different mechanisms aiming to minimize waste generation, thus decoupling economic growth from natural resources. Each year, an estimated one-third of all food produced is wasted; this is equivalent to 1.3 billion tons of food, which is worth around US$1 trillion or even $2.6 trillion when social and economic costs are included. In the fruit and vegetable sector, 45% of the total produced amount is lost in the production (post-harvest, processing, and distribution) and consumption chains. Therefore, it is necessary to find new technological and environmentally friendly solutions to utilize fruit wastes as new raw materials to develop and scale up the production of high value-added products and ingredients. Considering that the production and consumption of fruits has increased in the last years and following the need to find the sustainable use of different fruit side streams, this work aimed to describe the chemical composition and bioactivity of different fruit seeds consumed worldwide. A comprehensive focus is given on the extraction techniques of water-soluble and lipophilic compounds and in vitro/in vivo functionalities, and the link between chemical composition and observed activity is holistically explained.

Agricultura/economia , Frutas/química , Compostos Fitoquímicos/química , Sementes/química , Antioxidantes/química , Humanos , Resíduos Industriais/economia
Environ Sci Pollut Res Int ; 24(7): 6055-6060, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27005279


In trinitrotoluene (TNT) purification process, realized in industries, there are two washes carried out at the end of the procedure. The first is performed with vaporized water, from which the first effluent, called yellow water, is originated. Then, a second wash is performed using sodium sulfite, generating the red water effluent. The objective of this work was to get the best conditions for photocatalytic degradation of the second effluent, red water, in order to reduce toxicity and adjust legal parameters according to regulatory agencies for dumping these effluents into waterways. It has used a statistical evaluation for factor interaction (pH, concentration) that affects heterogeneous photocatalysis with titanium dioxide (TiO2). Thus, the treatment applied in the factorial experimental design consisted of using a volume equal to 500 mL of the effluent to 0.1 % by batch treatment, which has changed TiO2 pH and concentration, according to the design, with 20 min time for evaluation, where it was used as response to the reduction of UV-Vis absorption. According to the design responses, it has obtained optimum values for the parameters evaluated: pH = 6.5 and concentration of 100 mg/L of TiO2 were shown to be efficient when applied to red water effluent, obtaining approximately 91 % of discoloration.

Resíduos Industriais/análise , Trinitrotolueno , Águas Residuárias/química , Poluentes Químicos da Água , Purificação da Água/métodos , Fotólise , Titânio , Trinitrotolueno/análise , Trinitrotolueno/química , Trinitrotolueno/efeitos da radiação , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/química , Poluentes Químicos da Água/efeitos da radiação
J AAPOS ; 8(6): 576-9, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15616507


PURPOSE: To evaluate the results of the Susanna implant in children with primary congenital glaucoma. PATIENTS AND METHODS: The authors report a retrospective noncomparative interventional case series of data from 24 eyes from 24 pediatric patients who underwent Susanna implant surgery for primary congenital glaucoma. All the patients were operated by the same surgeon. The postoperative follow-up time was 24 months for all patients. Success was defined by an IOP higher than 6 mm Hg and less than or equal to 15 mm Hg, with the concomitant use of a single medication if necessary. RESULTS: The age range of the patients was 1 to 15 years and the mean age was 5.04 +/- 4.12 years. At 12 months, 87.5% of the patients were considered as success, and at 24 months, the proportion dropped to 79.16%. Mean preoperative and postoperative intraocular pressure were 26.17 +/- 5.16 and 14.04 +/- 4.19 mm Hg ( p < 0.001), respectively. All 24 children had undergone previous glaucoma surgeries. Cataract was the only complication found during follow-up, occurring in three patients. Cox's regression model did not show influence of gender ( P = 0.740) and previous surgery ( P = 0.262) on the outcome through time. Age at the time of surgery was the only variable which was statistically associated with success through time, younger patients presenting higher probability of failure ( P = 0.05). CONCLUSIONS: The results of the present study reinforce the role of drainage implants as a safe alternative in difficult cases of primary congenital glaucoma, after failure of the initial approach.

Humor Aquoso/metabolismo , Implantes para Drenagem de Glaucoma , Glaucoma/congênito , Glaucoma/cirurgia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Pressão Intraocular , Masculino , Implantação de Prótese , Estudos Retrospectivos , Resultado do Tratamento