Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 414
Filtrar
2.
3.
Neth Heart J ; 23(2): 79-81, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25523512
4.
J Magn Reson Imaging ; 40(2): 287-93, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24677686

RESUMO

PURPOSE: To explore differences in arterial stiffness of the aorta and carotid artery, assessed by pulse wave velocity (PWV), to evaluate the blood flow volume distribution towards the carotid circulation and to assess the effect of aging on the coupling between aortic and carotid PWV using velocity-encoded magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sixteen adult younger volunteers (age <30 years) and 16 older volunteers (age >45 years) underwent 3T MRI examination to assess aortic and carotid flow volumes and PWV using the transit time method. RESULTS: Aortic versus carotid PWV-ratio was 1.2 for younger volunteers and 0.95 for older volunteers, demonstrating leveling of wall stiffness. Furthermore, flow volume per minute in the internal carotid artery was lower for older versus younger volunteers (mean volume 177 ± 42 mL/min/m(2) vs. 147 ± 32 mL/min/m(2), P = 0.028), whereas aorta and common carotid artery flow volumes were not different. Consequently, the fraction of blood flow volume towards the brain was smaller for older versus younger volunteers (61 ± 9% versus 71 ± 8%, P = 0.002). CONCLUSION: PWV-leveling between aorta and carotid artery at older age is associated with a reduction in blood flow volume towards the brain. Velocity-encoded MRI can be used to evaluate PWV and flow volume distribution in the aortic arch and the carotid circulation.


Assuntos
Envelhecimento/fisiologia , Aorta Torácica/fisiologia , Velocidade do Fluxo Sanguíneo/fisiologia , Artérias Carótidas/fisiologia , Angiografia por Ressonância Magnética/métodos , Fluxo Pulsátil/fisiologia , Análise de Onda de Pulso/métodos , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Adulto Jovem
5.
J Electrocardiol ; 47(2): 183-90, 2014 Mar-Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24388489

RESUMO

BACKGROUND: In acute coronary syndrome (ACS), ST-segment elevation (STE), often associated with a completely occluded culprit artery, is an important ECG criterion for primary percutaneous coronary intervention (PCI). However, several studies showed that in ACS a completely occluded culprit artery can also occur with a non-ST-elevation (NSTE) ECG. In order to elucidate reasons for this discrepancy we examined ST injury vector orientation and magnitude in ACS patients with and without STE, all admitted for primary PCI and having a completely occluded culprit artery. METHODS: We studied the ECGs of 300 ACS patients (214/86 STE/NSTE; 228/72 single/multivessel disease) who had a completely occluded culprit artery during angiography prior to primary PCI. The J+60 injury vector orientation and magnitude were computed from Frank XYZ leads derived from the 10-s standard 12-lead ECG. RESULTS: Demographic and anthropomorphic characteristics of the STE and NSTE patients did not differ. STE patients had a higher rate of right coronary artery occlusions, and a lower rate of left circumflex occlusions than NSTE patients (43 vs. 31%, and 13 vs. 22%, respectively; P<0.05). Injury vector elevation and magnitude were larger in STE than in NSTE patients (32° ± 37° vs. 6° ± 39°, and 304 ± 145 µV vs. 134 ± 72 µV, respectively; P<0.0001). CONCLUSION: STE criteria favor certain injury vector directions and larger injury vector magnitudes. Obviously, several ACS patients with complete culprit artery occlusions requiring primary PCI do not fulfill these criteria. Our study suggests that STE-NSTE-based ACS stratification needs further enhancement.


Assuntos
Síndrome Coronariana Aguda/diagnóstico , Eletrocardiografia/métodos , Síndrome Coronariana Aguda/diagnóstico por imagem , Síndrome Coronariana Aguda/terapia , Angiografia Coronária , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Intervenção Coronária Percutânea
6.
Int J Cardiovasc Imaging ; 30(1): 91-8, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24170260

RESUMO

To evaluate the regional association between vessel wall morphology [i.e. cross-sectional vessel wall area (VWA)] and function [i.e. wall stiffness expressed in the pulse wave velocity (PWV)] in both the aortic arch and the left carotid artery. Thirty-two healthy volunteers (mean age 41 ± 16 years) underwent 3T MRI examination to assess PWV and VWA of the aorta and the left carotid artery. PWV was determined by the transit-time method with velocity-encoded MRI recordings of the systolic blood flow propagation. VWA was assessed for both the aorta and the carotid artery, by detecting lumen and outer vessel wall contours in cross-sectional black blood images. Linear regression analyses were used to test associations between aortic and carotid vessel wall area and stiffness. Within the same vascular territory, correlation between PWV and VWA was stronger than across vascular territories. For the aorta, the correlation between PWVAO and VWAAO (r = 0.71, p < 0.0001) was stronger than between PWVAO and VWACA (r = 0.53, p = 0.002). For the carotid artery, the correlation between PWVCA and VWACA (r = 0.61, p < 0.0001) was stronger than between PWVCA and VWAAO (r = 0.46, p = 0.008). Morphologic and functional vessel wall properties assessed in the aortic arch and the left carotid artery are significantly stronger associated within the same vascular territory rather than across different vascular territories.


Assuntos
Aorta Torácica/anatomia & histologia , Aorta Torácica/fisiologia , Artérias Carótidas/anatomia & histologia , Artérias Carótidas/fisiologia , Imagem por Ressonância Magnética , Rigidez Vascular , Adulto , Idoso , Velocidade do Fluxo Sanguíneo , Estudos Transversais , Feminino , Voluntários Saudáveis , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Análise de Onda de Pulso , Fluxo Sanguíneo Regional , Adulto Jovem
7.
Eur Heart J ; 34(38): 2949-3003, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23996286
8.
Ann Thorac Surg ; 96(4): 1390-1397, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23866804

RESUMO

BACKGROUND: The arterial switch operation is the current treatment for transposition of the great arteries. Long-term outcome mainly depends on the patency of the transferred coronary arteries. This study assessed the presence of abnormal coronary findings and neoaortic root dilation late after arterial switch operation. METHODS: In 30 adult patients after arterial switch operation (22 men, 22 ± 3 years), computed tomography angiography was performed to assess the coronary anatomy and abnormal coronary findings, defined as significant stenosis, interarterial coronary course, and acute angled coronary origins. Neoaortic root dimensions and coronary takeoff height were also assessed. RESULTS: The most common coronary anatomy pattern was found in 24 of 30 patients. Variant anatomy patterns were seen in 6 patients (5 with aberrant circumflex artery, 1 with a single ostium). The prevalence of abnormal coronary findings was higher in patients with variant coronary pattern as compared with patients with common coronary pattern (100% and 29%, respectively; p = 0.003). In particular, an acute angle of the coronary origin was frequently observed. In patients with an acute angle, larger dimensions of the aortic annulus (p = 0.016) and the sinus of Valsalva (p = 0.002) were observed. Moreover, a higher takeoff of the right (p = 0.030) and left (p = 0.002) coronary ostium was noted in patients with acute angles. CONCLUSIONS: Abnormal coronary findings were frequently observed in adult patients after arterial switch operation, especially in patients with a variant coronary anatomy pattern. Neoaortic root dilation and a higher coronary takeoff may explain part of the pathophysiology. Long-term follow-up is needed to determine the clinical significance of these findings.


Assuntos
Angiografia Coronária/métodos , Vasos Coronários/anatomia & histologia , Tomografia Computadorizada por Raios X , Transposição dos Grandes Vasos/cirurgia , Adolescente , Adulto , Procedimentos Cirúrgicos Cardíacos/métodos , Dilatação Patológica , Feminino , Seguimentos , Humanos , Masculino , Estudos Retrospectivos , Fatores de Tempo , Grau de Desobstrução Vascular , Adulto Jovem
9.
Int J Cardiol ; 168(4): 3327-33, 2013 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-23643425

RESUMO

BACKGROUND: The mechanism of the beneficial effects of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure (CHF) is largely unexplained. In our here-presented hypothesis-generating study we propose that part of these effects is mediated by the exercise-accompanying somatosensory nerve traffic. To demonstrate this, we compared the effects of periodic electrical somatosensory stimulation in patients with CHF with the effects of exercise training and with usual care. METHODS: In a randomized controlled study we measured, in CHF patients, changes in blood pressure, baroreflex sensitivity (BRS), neurohormones, exercise capacity and quality of life (QOL) in response to periodic somatosensory stimulation in the form of 2 Hz transcutaneous electrical nerve stimulation (TENS) at both feet, in response to conventional exercise training (EXTR) and, as control (CTRL), in patients with usual care only. RESULTS: Group sizes were N=31 (TENS group), N=25 (EXTR group) and N=30 (CTRL group), respectively. Practically all improvements in BRS, neurohormone concentrations, exercise capacity and QOL in the TENS group were comparable to, or sometimes even better than in the EXTR group. These improvements were not observed in the CTRL group. CONCLUSIONS: This study demonstrates that periodic electrical somatosensory stimulation is as effective as exercise training in improving BRS, neurohormone concentrations, exercise capacity and QOL in CHF patients. These results encourage exploration of exercise modalities that concentrate on rhythm rather than on effort, with the purpose to normalize autonomic derangement and neurohumoral activation in CHF.


Assuntos
Potenciais Somatossensoriais Evocados/fisiologia , Teste de Esforço/métodos , Exercício/fisiologia , Insuficiência Cardíaca/fisiopatologia , Insuficiência Cardíaca/terapia , Estimulação Elétrica Nervosa Transcutânea/métodos , Idoso , Feminino , Insuficiência Cardíaca/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade
11.
EuroIntervention ; 8(10): 1199-206, 2013 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-23425544

RESUMO

AIMS: The optimal drug-eluting stent (DES) in ST-elevation myocardial infarction (STEMI) patients remains unclear. We sought to compare the long-term performance of everolimus-eluting stents (EES) and Endeavor zotarolimus-eluting stents (E-ZES) in STEMI. METHODS AND RESULTS: The current analysis of a prospective registry included consecutive patients treated with EES or E-ZES for STEMI. Adjustment for measured confounders was done using Cox regression. In total, 931 patients met the inclusion criteria (412 EES and 519 E-ZES). Baseline characteristics were balanced, apart from a lower rate of renal insufficiency in EES. Median follow-up duration was 2.4 years (IQR 1.6-3.1). Mortality outcomes were similar. Up to three-year follow-up, the composite endpoint of cardiac death, target vessel-related myocardial infarction and target lesion revascularisation (TLR) was lower in EES; 9.7% vs. 13.7% in E-ZES (HR 0.64, 95% CI: 0.42-0.99), primarily driven by reduced TLR rates; 3.4% in EES vs. 7.3% in E-ZES (HR 0.46, 95% CI: 0.23-0.92). Definite stent thrombosis rates were low and similar between groups (1.1% in EES vs. 1.9% in E-ZES, p=0.190). CONCLUSIONS: Use of EES led to lower rates of the composite endpoint, driven by reduced TLR. This suggests that EES are more efficacious than Endeavor ZES in STEMI. Definite ST rates were low, and the strategy of second-generation DES implantation and the administration of upfront GP IIb/IIIa inhibitors appear to be safe in STEMI.


Assuntos
Stents Farmacológicos , Infarto do Miocárdio/terapia , Sirolimo/análogos & derivados , Adulto , Idoso , Eletrocardiografia , Everolimo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complexo Glicoproteico GPIIb-IIIa de Plaquetas/antagonistas & inibidores , Modelos de Riscos Proporcionais , Sistema de Registros , Sirolimo/administração & dosagem , Resultado do Tratamento
12.
Int J Cardiol ; 167(6): 2977-82, 2013 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-23000269

RESUMO

BACKGROUND: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. METHODS: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional PWV and aortic luminal areas were assessed by 1.5 T MRI. At 2-year follow-up, the incidence of luminal growth, defined as mean luminal diameter increase >2mm was determined for five aortic segments (S1, ascending aorta; S2, aortic arch; S3, thoracic descending aorta, S4, supra-renal and S5, infra-renal abdominal aorta). Regional PWV at baseline was considered increased when exceeding age-related normal PWV (healthy volunteers (n=26; mean age 30 ± 10 years, 15 male)) by two standard-errors. Sensitivity and specificity of regional PWV-testing for prediction of regional luminal growth were determined. RESULTS: Regional PWV at baseline was increased in 17 out of 102 segments (17%). Significant luminal growth at follow-up was reported in 14 segments (14%). The specificity of regional PWV-testing was ≥ 78% for all aortic segments, sensitivity was ≤ 33%. CONCLUSIONS: Regional PWV was significantly increased in MFS patients as compared to healthy volunteers within similar age range, in all aortic segments except the ascending aorta. Furthermore, regional PWV-assessment has moderate to high specificity for predicting absence of regional aortic luminal growth for all aortic segments in MFS patients.


Assuntos
Aorta/patologia , Imagem por Ressonância Magnética/métodos , Síndrome de Marfan/diagnóstico , Análise de Onda de Pulso/métodos , Rigidez Vascular/fisiologia , Adulto , Aorta/fisiopatologia , Feminino , Seguimentos , Humanos , Masculino , Síndrome de Marfan/fisiopatologia , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Método Simples-Cego , Adulto Jovem
13.
Int J Cardiovasc Imaging ; 29(1): 221-8, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22576679

RESUMO

To determine the rate of subsequent invasive coronary angiography (ICA) and revascularization in relation to computed tomography coronary angiography (CTA) results. In addition, independent determinants of subsequent ICA and revascularization were evaluated. CTA studies were performed using a 64-row (n = 413) or 320-row (n = 224) multidetector scanner. The presence and severity of CAD were determined on CTA. Following CTA, patients were followed up for 1 year for the occurrence of ICA and revascularization. A total of 637 patients (296 male, 56 ± 12 years) were enrolled and 578 CTA investigations were available for analysis. In patients with significant CAD on CTA, subsequent ICA rate was 76%. Among patients with non-significant CAD on CTA, subsequent ICA rate was 20% and among patients with normal CTA results, subsequent ICA rate was 5.7% (p < 0.001). Of patients with significant CAD on CTA, revascularization rate was 47%, as compared to a revascularization rate of 0.6% in patients with non-significant CAD on CTA and no revascularizations in patients with a normal CTA results (p < 0.001). Significant CAD on CTA and significant three-vessel or left main disease on CTA were identified as the strongest independent predictors of ICA and revascularization. CTA results are strong and independent determinants of subsequent ICA and revascularization. Consequently, CTA has the potential to serve as a gatekeeper for ICA to identify patients who are most likely to benefit from revascularization and exclude patients who can safely avoid ICA.


Assuntos
Angiografia Coronária/métodos , Doença da Artéria Coronariana/diagnóstico por imagem , Vasos Coronários/diagnóstico por imagem , Tomografia Computadorizada Multidetectores , Adulto , Idoso , Distribuição de Qui-Quadrado , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Revascularização Miocárdica , Razão de Chances , Seleção de Pacientes , Valor Preditivo dos Testes , Prognóstico , Interpretação de Imagem Radiográfica Assistida por Computador , Sistema de Registros , Estudos Retrospectivos , Índice de Gravidade de Doença , Fatores de Tempo , Procedimentos Desnecessários
14.
Heart Vessels ; 28(2): 166-72, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22349692

RESUMO

Previous angiographic studies have shown that almost two-thirds of vulnerable plaques are located in non-obstructive lesions. Possibly, the maximum necrotic core (Max NC) area is not always identical to the site of most severe stenosis. Therefore, the purpose of this study was to evaluate the potential difference in location between the maximum necrotic core area and the site of most severe narrowing as assessed by virtual histology intravascular ultrasound (VH IVUS). Overall, 77 patients (139 vessels) underwent VH IVUS. The Max NC site was defined as the cross section with the largest necrotic core area per vessel. The site of most severe narrowing was defined as the minimum lumen area (MLA). Per vessel, the distance from both the Max NC site and MLA site to the origo of the coronary artery was evaluated. In addition, the presence of a virtual histology-thin cap fibroatheroma (VH-TCFA) was assessed. The mean difference (mm) between the MLA site and Max NC site was 10.8 ± 20.6 mm (p < 0.001). Interestingly, the Max NC site was located at the MLA site in seven vessels (5%) and proximally to the MLA site in 92 vessels (66%). Importantly, a higher percentage of VH-TCFA was demonstrated at the Max NC site as compared to the MLA site (24 vs. 9%, p < 0.001). In conclusion, the present findings demonstrate that the Max NC area is rarely at the site of most severe narrowing. Most often, the Max NC area is located proximal to the site of most severe narrowing.


Assuntos
Estenose Coronária/diagnóstico por imagem , Vasos Coronários/diagnóstico por imagem , Placa Aterosclerótica , Ultrassonografia de Intervenção , Idoso , Distribuição de Qui-Quadrado , Angiografia Coronária , Estenose Coronária/patologia , Vasos Coronários/patologia , Feminino , Fibrose , Humanos , Masculino , Pessoa de Meia-Idade , Necrose , Valor Preditivo dos Testes , Prognóstico , Estudos Retrospectivos , Índice de Gravidade de Doença , Calcificação Vascular/diagnóstico por imagem , Calcificação Vascular/patologia
16.
Invest Radiol ; 47(12): 697-704, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22996317

RESUMO

OBJECTIVES: Magnetic resonance imaging (MRI) of the vessel wall enables determination of luminal area, vessel wall thickness, and atherosclerotic plaque characteristics. For clinical application, high spatial resolution, derived from optimal signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), is paramount. Vessel wall MRI is expected to benefit from higher magnetic field strength. Therefore, the purposes of the present study were to develop an ultrahigh-field 7-T MRI hardware and protocols for vessel wall imaging of the carotid artery and to compare quantitative parameters of vessel wall morphology and image quality between 3-T and 7-T MRI. MATERIAL AND METHODS: Eighteen volunteers (11 men and 7 women; mean [SD] age, 29 [7] years) underwent MRI examinations at 7 T (using a custom-built surface transmit/receive coil of 15-cm diameter) and at 3 T (using a commercial phased-array coil with 2 flexible oval elements, 14 × 17 cm each). Magnetic resonance imaging of the left common carotid artery vessel wall was performed at 7 T with identical in-plane resolution as that of 3-T MRI (0.46 × 0.46 mm), providing transverse T1- and T2-weighted images. Blinded analysis of morphologic measurements (luminal area and vessel wall area), SNR for vessel wall (SNRVW), and the CNR between the lumen and the vessel wall were compared between 7 and 3 T. RESULTS: Morphologic carotid vessel wall measurements were comparable between 7 and 3 T for both T1-weighted images (luminal area: intraclass correlation [ICC], 0.81 and vessel wall area: ICC, 0.84) and T2-weighted images (luminal area: ICC, 0.97 and vessel wall area: ICC, 0.92). At 7 T, SNRVW and CNR were significantly higher compared with 3-T MRI for both T1- (P < 0.001) and T2-weighted images (P < 0.05), with gain factors ranging from 1.3 to 3.6. CONCLUSIONS: Ultrahigh-field 7-T MR carotid vessel wall imaging is feasible. 7-T MRI of the common carotid artery has comparable accuracy for determining luminal area and vessel wall area and has improved SNRVW and CNR compared with 3-T MRI. Therefore, ultrahigh-field 7-T vessel wall MRI may enable a more detailed assessment of plaque morphology.


Assuntos
Artérias Carótidas/anatomia & histologia , Imagem por Ressonância Magnética/métodos , Adulto , Protocolos Clínicos , Feminino , Humanos , Masculino
17.
Eur J Nucl Med Mol Imaging ; 39(10): 1599-608, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22790878

RESUMO

PURPOSE: Despite its high prognostic value, widespread clinical implementation of (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is hampered by a lack of validation and standardization. The purpose of this study was to assess the reliability of planar (123)I-MIBG myocardial scintigraphy in patients with heart failure (HF). METHODS: Planar myocardial MIBG images of 70 HF patients were analysed by two experienced and one inexperienced observer. The reproducibility of early and delayed heart-to-mediastinum (H/M) ratios, as well as washout rate (WR) calculated by two different methods, was assessed using the intraclass correlation coefficient (ICC) and the Bland-Altman analysis. In addition, a subanalysis in patients with a very low H/M ratio (delayed H/M ratio <1.4) was performed. The delayed H/M ratio was also assessed using fixed-size oval and circular cardiac regions of interest (ROI). RESULTS: Intra- and interobserver analyses and experienced versus inexperienced observer analysis showed excellent agreement for the measured early and delayed H/M ratios and WR on planar (123)I-MIBG images (the ICCs for the delayed H/M ratios were 0.98, 0.96 and 0.90, respectively). In addition, the WR without background correction resulted in higher reliability than the WR with background correction (the interobserver Bland-Altman 95 % limits of agreement were -2.50 to 2.16 and -10.10 to 10.14, respectively). Furthermore, the delayed H/M ratio measurements remained reliable in a subgroup of patients with a very low delayed H/M ratio (ICC 0.93 for the inter-observer analysis). Moreover, a fixed-size cardiac ROI could be used for the assessment of delayed H/M ratios, with good reliability of the measurement. CONCLUSION: The present study showed a high reliability of planar (123)I-MIBG myocardial scintigraphy in HF patients, confirming that MIBG myocardial scintigraphy can be implemented easily for clinical risk stratification in HF.


Assuntos
3-Iodobenzilguanidina , Insuficiência Cardíaca/diagnóstico por imagem , Imagem de Perfusão do Miocárdio/normas , Compostos Radiofarmacêuticos , Idoso , Tomografia Computadorizada por Emissão de Fóton Único de Sincronização Cardíaca/normas , Feminino , Humanos , Masculino , Prognóstico , Reprodutibilidade dos Testes
18.
Arch Cardiol Mex ; 82(2): 170-80, 2012 Apr-Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-22735658

RESUMO

Disclosure of potential conflicts of interest is used by biomedical journals to guarantee credibility and transparency of the scientific process. Conflict of interest disclosure, however, is not systematically nor consistently dealt with by journals. Recent joint editorial efforts paved the way towards the implementation of uniform vehicles for conflicts of interest disclosure. This paper provides a comprehensive editorial perspective on classical conflict of interest-related issues. New insights into current conflicts of interest policies and practices among European Society of Cardiology national cardiovascular journals, as derived from a cross-sectional survey using a standardized questionnaire, are discussed.


Assuntos
Cardiologia , Conflito de Interesses , Revelação/normas , Publicações Periódicas como Assunto/normas , Sociedades Médicas
19.
J Magn Reson Imaging ; 36(6): 1470-6, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22730278

RESUMO

PURPOSE: To evaluate the effect of spatial (ie, number of sampling locations along the aorta) and temporal sampling density on aortic pulse wave velocity (PWV) assessment from velocity-encoded MRI in patients with Marfan syndrome (MFS). MATERIALS AND METHODS: Twenty-three MFS patients (12 men, mean age 36 ± 14 years) were included. Three PWV-methods were evaluated: 1) reference PWV(i.p.) from in-plane velocity-encoded MRI with dense temporal and spatial sampling; 2) conventional PWV(t.p.) from through-plane velocity-encoded MRI with dense temporal but sparse spatial sampling at three aortic locations; 3) EPI-accelerated PWV(t.p.) with sparse temporal but improved spatial sampling at five aortic locations with acceleration by echo-planar imaging (EPI). RESULTS: Despite inferior temporal resolution, EPI-accelerated PWV(t.p.) showed stronger correlation (r = 0.92 vs. r = 0.65, P = 0.03) with reference PWV(i.p.) in the total aorta, with less error (8% vs. 16%) and variation (11% vs. 27%) as compared to conventional PWV(t.p.) . In the aortic arch, correlation was comparable for both EPI-accelerated and conventional PWV(t.p.) with reference PWV(i.p.) (r = 0.66 vs. r = 0.67, P = 0.46), albeit 92% scan-time reduction by EPI-acceleration. CONCLUSION: Improving spatial sampling density by adding two acquisition planes along the aorta results in more accurate PWV assessment, even when temporal resolution decreases. For regional PWV assessment in the aortic arch, EPI-accelerated and conventional PWV assessment are comparably accurate. Scan-time reduction makes EPI-accelerated PWV assessment the preferred method of choice.


Assuntos
Aorta/patologia , Aorta/fisiopatologia , Interpretação de Imagem Assistida por Computador/métodos , Imagem por Ressonância Magnética/métodos , Síndrome de Marfan/patologia , Síndrome de Marfan/fisiopatologia , Análise de Onda de Pulso/métodos , Adulto , Algoritmos , Velocidade do Fluxo Sanguíneo , Interpretação Estatística de Dados , Feminino , Humanos , Aumento da Imagem/métodos , Masculino , Reprodutibilidade dos Testes , Tamanho da Amostra , Sensibilidade e Especificidade
20.
Arch. cardiol. Méx ; 82(2): 170-180, abr.-jun. 2012. tab
Artigo em Espanhol | LILACS | ID: lil-657954

RESUMO

Las revistas biomédicas utilizan la declaración de posibles conflictos de intereses para garantizar la credibilidad y la transparencia del proceso científico. Sin embargo, las revistas no abordan la declaración de conflictos de intereses de manera sistemática ni uniforme. Recientes esfuerzos editoriales conjuntos han abierto el camino a la aplicación de herramientas uniformes para la declaración de conflictos de intereses. En este artículo se presenta una visión integral sobre cuestiones clásicas relacionadas con los conflictos de intereses desde un punto de vista editorial. Además, a partir de los datos de un estudio transversal basado en el empleo de un cuestionario estandarizado, se comentan nuevas apreciaciones sobre las políticas y los actuales procedimientos editoriales relativos a los conflictos de intereses en las diversas revistas cardiovasculares nacionales de la Sociedad Europea de Cardiología.


Disclosure of potential conflicts of interest is used by biomedical journals to guarantee credibility and transparency of the scientific process. Conflict of interest disclosure, however, is not systematically nor consistently dealt with by journals. Recent joint editorial efforts paved the way towards the implementation of uniform vehicles for conflicts of interest disclosure. This paper provides a comprehensive editorial perspective on classical conflict of interest-related issues. New insights into current conflicts of interest policies and practices among European Society of Cardiology national cardiovascular journals, as derived from a cross-sectional survey using a standardized questionnaire, are discussed.


Assuntos
Autoria/normas , Conflito de Interesses , Revelação , Políticas Editoriais , Publicações Periódicas como Assunto , Cardiologia , Coleta de Dados , Revelação/normas , Indústria Farmacêutica/economia , Indústria Farmacêutica , Europa (Continente) , Publicações Periódicas como Assunto/normas , Apoio à Pesquisa como Assunto , Sociedades Médicas
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA