1.
Clin Immunol
; 207: 36-39, 2019 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31299380
RESUMO
Overproduction of interleukin (IL)-18 is closely related to the pathogenesis of adult-onset Still's disease (AOSD) and the development of macrophage activation syndrome (MAS), a life-threating complication of AOSD. We reported three cases of MAS occurring in infants born to mothers with AOSD. The infants developed MAS at age 13 and 8â¯days and at birth. Serum IL-18 levels were extremely elevated in all infants (147,000â¯pg/mL; 378,000â¯pg/mL; 95,000â¯pg/mL) as well as in their mothers (58,500â¯pg/mL; 367,000â¯pg/mL; 84,000â¯pg/mL). Physicians should be aware that infants born to mothers with AOSD are at a risk of developing MAS. Serum IL-18 levels in mothers with AOSD and their infants should be monitored.