What does the Thinking about Relationalism and Humanness in African Philosophy imply for Different Modes of Being Present in the Metaverse?

In this article, I interrogate whether the deployment and development of the Metaverse should take into account African values and modes of knowing to foster the uptake of this hyped technology in Africa. Specifically, I draw on the moral norms arising from the components of communal interactions and humanness in Afro-communitarianism to contend that the deployment of the Metaverse and its development ought to reflect core African moral values to foster its uptake in the region. To adequately align the Metaverse with African core values and thus foster its uptake among Africans, significant technological advancement that makes simulating genuine human experiences possible must occur. Additionally, it would be necessary for the developers and deployers to ensure that higher forms of spiritual activities can be had in the Metaverse to foster its uptake in Africa. Finally, I justify why the preceding points do not necessarily imply that the Metaverse will have a higher moral status than real life on the moral scale that can be grounded in Afro-communitarianism.

Repurposing of therapeutic antibodies against dengue virus envelope protein receptor binding domain.

Dengue virus (DENV) is the leading cause of numerous deaths every year due to its high infectivity. In this study we have tried to target the DENV envelope protein receptor binding domain, the region crucial for binding to host receptors which leads to membrane fusion and entry of the viral genome into the human host cell. We have taken 13 known FDA approved antiviral therapeutic antibodies from therapeutic antibody database and tried to repurpose them against the DENV envelope protein. Based on the humanness analysis, 10 antibodies were selected against the DENV envelope protein. Computational affinity maturation of the 10 selected antibodies was performed to increase their binding affinity and specificity against the DENV envelope protein which ultimately led to 8 mutant antibodies having better binding affinity than the native ones. Molecular Dynamics (MD) simulation shows that, the stability of the complexes involving both the native and mutant antibodies were found to be the same although the binding energy between the protein and the respective antibodies was seen to improve upon computational affinity maturation. Contact analyses show similar robustness of the interaction for both the mutant and native antibodies during complex formation with the DENV envelope protein. This has led to the selection of total 18 antibodies including 10 natural and 8 affinity matured mutants which have a high probability of interacting with the DENV envelope protein. Finally, based on all these analyses along with heated MD simulation, Bamlanivimab, Etesivimab and Tixagevimab with a mutation of residue 100 of the heavy chain from serine to tyrosine were selected as prospective therapeutic antibodies to combat DENV infection. This study may open a new avenue in designing therapeutics to combat Dengue viral infection.

Prospects for the computational humanization of antibodies and nanobodies.

To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the 'humanness' of the candidate drug. However, despite the emergence of new discovery technologies, many of which start from entirely human gene fragments, most antibody therapeutics continue to be derived from non-human sources with concomitant humanization to increase their human compatibility. Early experimental humanization strategies that focus on CDR loop grafting onto human frameworks have been critical to the dominance of this discovery route but do not consider the context of each antibody sequence, impacting their success rate. Other challenges include the simultaneous optimization of other drug-like properties alongside humanness and the humanization of fundamentally non-human modalities such as nanobodies. Significant efforts have been made to develop in silico methodologies able to address these issues, most recently incorporating machine learning techniques. Here, we outline these recent advancements in antibody and nanobody humanization, focusing on computational strategies that make use of the increasing volume of sequence and structural data available and the validation of these tools. We highlight that structural distinctions between antibodies and nanobodies make the application of antibody-focused in silico tools to nanobody humanization non-trivial. Furthermore, we discuss the effects of humanizing mutations on other essential drug-like properties such as binding affinity and developability, and methods that aim to tackle this multi-parameter optimization problem.

Discrepancies in perceived humanness between spatially filtered and unfiltered faces and their associations with uncanny feelings.

Human and artificial features that coexist in certain types of human-like robots create a discrepancy in perceived humanness and evoke uncanny feelings in human observers. However, whether this perceptual mismatch in humanness occurs for all faces, and whether it is related to the uncanny feelings toward them, is unknown. We investigated this by examining perceived humanness for a variety of natural images of robot and human faces with different spatial frequency (SF) information: that is, faces with only low SF, middle SF, and high SF information, and intact (spatially unfiltered) faces. Uncanny feelings elicited by these faces were also measured. The results showed perceptual mismatches that LSF, MSF, and HSF faces were perceived as more human than intact faces. This was particularly true for intact robot faces that looked slightly human, which tended to evoke strong uncanny feelings. Importantly, the mismatch in perceived humanness between the intact and spatially filtered faces was positively correlated with uncanny feelings toward intact faces. Given that the human visual system performs SF analysis when processing faces, the perceptual mismatches observed in this study likely occur in real life for all faces, and as such might be a ubiquitous source of uncanny feelings in real-life situations.

Perceiving humanness across ages: neural correlates and behavioral patterns.

Humanness perception, which attributes fundamental and unique human characteristics to other objects or people, has significant consequences for people's interactions. Notably, the failure to perceive humanness in older adults can lead to prejudice. This study investigates the effect of a target's age on humanness perception in terms of two dimensions: agency (the ability to act and do) and experience (the ability to feel and sense). We also examined brain activity using a magnetic resonance imaging (MRI) scanner in order to understand the underlying neural mechanisms. Healthy university students viewed the facial images of older and younger individuals and judged the humanness of each individual in terms of agency and experience while inside the MRI scanner. The results indicated that older adults were rated higher on experience, and no difference was found in ratings for agency between younger and older face images. Analysis of brain imaging data indicated that positive functional connectivity between the ventral and dorsal regions of the medial prefrontal cortex (mPFC) was greater when judging the humanness of younger faces than older faces. We also found that the negative functional connectivity between the left inferior frontal gyrus and postcentral gyrus was greater when judging the humanness of older faces as compared to that of younger faces. Although the current study did not show distinct brain activities related to humanness perception, it suggests the possibility that different brain connectivities are related to humanness perception regarding targets belonging to different age groups.

Joint action with human and robotic co-actors: Self-other integration is immune to the perceived humanness of the interacting partner.

When performing a joint action task, we automatically represent the action and/or task constraints of the co-actor with whom we are interacting. Current models suggest that, not only physical similarity, but also abstract, conceptual features shared between self and the interacting partner play a key role in the emergence of joint action effects. Across two experiments, we investigated the influence of the perceived humanness of a robotic agent on the extent to which we integrate the action of that agent into our own action/task representation, as indexed by the Joint Simon Effect (JSE). The presence (vs. absence) of a prior verbal interaction was used to manipulate robot's perceived humanness. In Experiment 1, using a within-participant design, we had participants perform the joint Go/No-go Simon task with two different robots. Before performing the joint task, one robot engaged in a verbal interaction with the participant and the other robot did not. In Experiment 2, we employed a between-participants design to contrast these two robot conditions as well as a human partner condition. In both experiments, a significant Simon effect emerged during joint action and its amplitude was not modulated by the humanness of the interacting partner. Experiment 2 further showed that the JSE obtained in robot conditions did not differ from that measured in the human partner condition. These findings contradict current theories of joint action mechanisms according to which perceived self-other similarity is a crucial determinant of self-other integration in shared task settings.

Effects of avatar shape and motion on mirror neuron system activity.

Humanness is an important characteristic for facilitating interpersonal communication, particularly through avatars in the metaverse. In this study, we explored the mirror neuron system (MNS) as a potential neural basis for perceiving humanness in avatars. Although previous research suggests that the MNS may be influenced by human-like shape and motion, the results have been inconsistent due to the diversity and complexity of the MNS investigation. Therefore, this study aims to investigate the effects of shape and motion humanness in avatars on MNS activity. Participants viewed videos of avatars with four different shapes (HumanShape, AngularShape, AbbreviatedShape, and ScatteredShape) and two types of motion (HumanMotion and LinearMotion), and their µ-wave attenuation in the electroencephalogram was evaluated. Results from a questionnaire indicated that HumanMotion was perceived as human-like, while AbbreviatedShape and ScatteredShape were seen as non-human-like. AngularShape's humanity was indefinite. The MNS was activated as expected for avatars with human-like shapes and/or motions. However, for non-human-like motions, there were differences in activity trends depending on the avatar shape. Specifically, avatars with HumanShape and ScatteredShape in LinearMotion activated the MNS, but the MNS was indifferent to AngularShape and AbbreviatedShape. These findings suggest that when avatars make non-human-like motions, the MNS is activated not only for human-like appearance but also for the scattered and exaggerated appearance of the human body in the avatar shape. These findings could enhance inter-avatar communication by considering brain activity.

Enhancing component-specific trust with consumer automated systems through humanness design.

Consumer automation is a suitable venue for studying the efficacy of untested humanness design methods for promoting specific trust in multi-component systems. Subjective (trust, self-confidence) and behavioural (use, manual override) measures were recorded as 82 participants interacted with a four-component automation-bearing system in a simulated smart home task for two experimental blocks. During the first block all components were perfectly reliable (100%). During the second block, one component became unreliable (60%). Participants interacted with a system containing either a single or four simulated voice assistants. In the single-assistant condition, the unreliable component resulted in trust changes for every component. In the four-assistant condition, trust decreased for only the unreliable component. Across agent-number conditions, use decreased between blocks for only the unreliable component. Self-confidence and overrides exhibited ceiling and floor effects, respectively. Our findings provide the first evidence of effectively using humanness design to enhance component-specific trust in consumer systems.Practitioner summary: Participants interacted with simulated smart-home multi-component systems that contained one or four voiced assistants. In the single-voice condition, one component's decreasing reliability coincided with trust changes for all components. In the four-voice condition, trust decreased for only the decreasingly reliable component. The number of voices did not influence use strategies.Abbreviations: ACC: adaptive cruise control; CST: component-specific trust; SWT: system-wide trust; UAV: unmanned aerial vehicle; CPRS: complacency potential rating scale; MANOVA: multivariate analysis of variance.

The Faure report, Sylvia Wynter and the undoing of the Man of lifelong learning.

It is rare in contemporary times to encounter international education policy reports that inspire hope and excitement for the future, such as we are offered in the 1972 report of the International Commission on the Development of Education set up by UNESCO in 1971 and chaired by Edgar Faure. Learning to be: The world of education today and tomorrow, also known as the Faure report, is both philosophical and "of a practical nature", aiming "to lead to action". Faure and his collaborators offered governments, scholars and educational actors evocative concepts for a society-to-come, such as lifelong education (and later, lifelong learning), the learning society, international solidarity and personalised learning. Animating the report and its imaginary of lifelong learning is "the ideal of the complete man", a modernist project to realise Man's destiny at the centre of the universe. The Faure report and the ideal of lifelong learning continue to inspire education policy today. But in the context of climate crisis and deeper global inequality, what kind of enabling future is possible under the guidance of the exclusionary story of Man-as-human? To what extent can the Faure report continue to inspire? This article brings the Faure report's utopia of Man into conversation with Black feminist theorist Sylvia Wynter, exploring the idea central to Wynter's work that if learning is the way out of perpetual crises, of socio-biological collapse, a force for equity, democracy and justice that the authors of the Faure report envisioned it to be, then it must be de-coupled from the overrepresented, biocentric, 'referent-we' of Man-as-human. Wynter proposes a different future for humanness. The article concludes by speculating what this future might suggest for the material grounding of scholarly practices in adult education and beyond.

Le rapport Faure, Sylvia Wynter et le détricotage de l'Homme de l'apprentissage tout au long de la vie ­ Il est rare à notre époque de tomber sur des rapports politiques internationaux sur l'éducation qui inspirent de l'enthousiasme pour l'avenir comme l'a fait le rapport de 1972 de la Commission internationale sur le développement de l'éducation, créée par l'UNESCO en 1971 et présidée par Edgar Faure. Apprendre à être, également connu sous le nom de rapport Faure, est  à la fois philosophique et « d'ordre pratique ¼, visant « à conduire à l'action ¼. Faure et ses collaborateurs offrirent aux gouvernements, aux universitaires et aux acteurs de l'éducation des concepts évocateurs pour une société à venir, par exemple l'éducation permanente (et plus tard l'apprentissage tout au long de la vie), la société apprenante, la solidarité internationale et l'apprentissage personnalisé. « L'idéal de l'homme complet ¼, un projet moderniste visant à réaliser le destin de l'Homme au centre de l'univers, animait le rapport et son imaginaire de l'apprentissage tout au long de la vie. Le rapport Faure et l'idéal de l'apprentissage tout au long de la vie continuent aujourd'hui d'inspirer la politique de l'éducation. Mais dans le contexte de la crise climatique et des profondes inégalités dans le monde, quel type de future peut-on envisager quand on est guidé par le narratif exclusif de l'Homme en tant qu'humain ? Dans quelle mesure le rapport Faure peut-il encore être une inspiration ? Le présent article engage un dialogue entre l'utopie de l'Homme du rapport Faure et la théoricienne féministe noire Sylvia Wynter, et il se penche sur l'idée centrale de ses travaux selon laquelle si l'apprentissage est la voie de sortie des crises perpétuelles et de l'effondrement sociobiologique, et une force d'équité, de démocratie et de justice comme le considéraient les auteurs du rapport Faure, alors, il faut le désengager de ce « nous ¼ surreprésenté et biocentrique de l'Homme en tant qu'humain auquel il se réfère. Sylvia Wynter propose un avenir différent pour l'humanisme. L'article conclut en spéculant sur ce que cet avenir pourrait proposer comme base matérielle pour les pratiques scientifiques dans l'éducation des adultes et au-delà.

Rethinking benefit sharing in collaborative human genetic research from an Afrocommunitarian perspective.

This article draws on reflections about humanness, friendliness and partiality, in the writings of Afro-communitarians to develop principles for thinking critically about why benefit sharing, what may count as benefits within the context of human research in Africa and the limits of the obligation of benefit sharing. Suppose the thinking about humanness, friendliness, and partiality in Afro-communitarianism were the foundation of human genetic research in Africa, then, individuals who have contributed to research or borne its burden would benefit from its rewards. This is even more important if participants have pressing needs that researchers and/or research institutions can help ease. A failure to aid sample contributors and data providers in need when researchers and research institutions can-as well as an indifference to the serious needs of contributors-are failures to exhibit friendliness in the relevant ways. Finally, though providing benefits to contributors can be an important way of showing humanity to them, nonetheless, this obligation is not absolute and may be limited by the stronger obligation of shared experience-to advance science. Studies are still required to inquire how well these norms will work in practice and inform regulatory and legal frameworks.

Is It Time for Australia to Reassess Its Legislation on Human Embryo Experimentation?

The United Kingdom Warnock Committee (1984) was a landmark contributor to the ethics and law governing human embryo experimentation. It recommended a time limit up to 14 days of development after fertilisation within which such experimentation may take place, which mirrors the late 1970s' proposal of the United States Department of Health, Education, and Welfare Ethics Advisory Board (EAB). This study analyses the EAB's and the Warnock Committee's reasoning and conclusions regarding what constitutes ethical behaviour towards the human embryo. Current embryology and recently created embryo-like structures are considered. After the Warnock Report, several Australian Federal and State committees in Australia investigated the ethics which should guide experimentation on human embryos. The reports of these Australian committees are reviewed and the potential influence of both earlier committees on their deliberations is discussed. The rationale informing current Australian law governing human embryo experimentation is examined. Considering current more advanced knowledge of embryology, it is concluded that this legislation should be reassessed.

BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning.

Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development. Traditionally, humanization is manual, laborious, and requires expert knowledge. Although automation efforts are advancing, existing methods are either demonstrated on a small scale or are entirely proprietary. To predict the immunogenicity risk, the human-likeness of sequences can be evaluated using existing humanness scores, but these lack diversity, granularity or interpretability. Meanwhile, immune repertoire sequencing has generated rich antibody libraries such as the Observed Antibody Space (OAS) that offer augmented diversity not yet exploited for antibody engineering. Here we present BioPhi, an open-source platform featuring novel methods for humanization (Sapiens) and humanness evaluation (OASis). Sapiens is a deep learning humanization method trained on the OAS using language modeling. Based on an in silico humanization benchmark of 177 antibodies, Sapiens produced sequences at scale while achieving results comparable to that of human experts. OASis is a granular, interpretable and diverse humanness score based on 9-mer peptide search in the OAS. OASis separated human and non-human sequences with high accuracy, and correlated with clinical immunogenicity. BioPhi thus offers an antibody design interface with automated methods that capture the richness of natural antibody repertoires to produce therapeutics with desired properties and accelerate antibody discovery campaigns. The BioPhi platform is accessible at https://biophi.dichlab.org and https://github.com/Merck/BioPhi.

The Impact of Sexualized Video Game Content and Cognitive Load on State Rape Myth Acceptance.

The potential negative impact of sexualized video games on attitudes toward women is an important issue. Studies that have examined this issue are rare and contain a number of limitations. Therefore, it largely remains unclear whether sexualized video games can have an impact on attitudes toward women. This study examined the consequences of sexualized video game content and cognitive load (moderator) on rape victim blame and rape perpetrator blame (used as a proxy of rape myth acceptance), and whether the degree of humanness of the victim and of the perpetrator mediated these effects. Participants (N = 142) played a video game using sexualized or non-sexualized female characters. Cognitive load was manipulated by setting the difficulty level of the game to low or high. After gameplay, participants read a rape date story, and were then asked to judge the victim's and the perpetrator's degree of responsibility and humanness. Based on the General Aggression Model (GAM), it was hypothesized that playing the video game with a sexualized content would increase the responsibility assigned to the victim and diminish the responsibility assigned to the perpetrator. Further, degree of humanness of the victim and the perpetrator was expected to mediate this relation. The results were partially consistent with these predictions: Playing a video game containing sexualized female characters increased rape victim blame when cognitive load was high, but did not predict degree of humanness accorded to the victim. Concerning the perpetrator, video game sexualization did not influence responsibility, but partly influenced humanness. This study concludes that video games impact on attitudes toward women and this, in part, due to its interactive nature.

Improving nursing students' perspective taking, perceptions of humanness, and attitudes toward older adults.

Whereas prior work has examined the role of nursing courses in improving empathic skills and reducing dehumanization of older adults, little research has explored how perspective taking and perceptions of humanness of older adults acquired through nursing curricula predict attitudes toward this age group. Nursing students (N = 43) completed surveys at the beginning (Time 1) and end of gerontological coursework (Time 2). Perspective taking and perceived human nature and human uniqueness of older adults increased from Time 1 to Time 2. Perceived human nature of older adults was associated with more positive attitudes at the end of the semester, compared to the beginning. Improved perceptions of the human nature of older adults also predicted lower ageism at the end of the semester. Strategies for improving perspective taking and perceptions of humanness of older adults in nursing courses are discussed.

Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity.

Transgenic animals incorporating human antibody genes are extremely attractive for drug development because they obviate subsequent antibody humanization procedures required for therapeutic translation. Transgenic platforms have previously been established using mice, but also more recently rats, chickens, and cows and are now in abundant use for drug development. However, rabbit-based antibody generation, with a strong track record for specificity and affinity, is able to include gene conversion mediated sequence diversification, thereby enhancing binder maturation and improving the variance/selection of output antibodies in a different way than in rodents. Since it additionally frequently permits good binder generation against antigens that are only weakly immunogenic in other organisms, it is a highly interesting species for therapeutic antibody generation. We report here on the generation, utilization, and analysis of the first transgenic rabbit strain for human antibody production. Through the knockout of endogenous IgM genes and the introduction of human immunoglobulin sequences, this rabbit strain has been engineered to generate a highly diverse human IgG antibody repertoire. We further incorporated human CD79a/b and Bcl2 (B-cell lymphoma 2) genes, which enhance B-cell receptor expression and B-cell survival. Following immunization against the angiogenic factor BMP9 (Bone Morphogenetic Proteins 9), we were able to isolate a set of exquisitely affine and specific neutralizing antibodies from these rabbits. Sequence analysis of these binders revealed that both somatic hypermutation and gene conversion are fully operational in this strain, without compromising the very high degree of humanness. This powerful new transgenic strategy will allow further expansion of the use of endogenous immune mechanisms in drug development.

The life stories and experiences of the children admitted to the Institute for Imbecile Children from 1895 to 1913.

BACKGROUND: South African scholarship on intellectual disability has produced a sizeable body of research, yet there are numerous areas where there is a paucity of research. One area in which there is a conspicuous paucity of research is historical studies of people with intellectual disability (PWID). The existing works devoted to the history of PWID in South Africa are primarily focused on the legal provisions and institutions for the protection and care of PWID. Missing from these works are the life stories and experiences of PWID. OBJECTIVES: The article offers a study devoted to the life stories and experiences of the children with intellectual disability (CWID) who were admitted to the Institute for Imbecile Children from 1895 to 1913. The institute opened in April 1895 in Makhanda (formerly known as Grahamstown), South Africa. The institute was the first of its kind in the Cape Colony for CWID. METHOD: The study presents a qualitative investigation of the life stories and experiences of the children that were recorded in the institute's casebook. The entire set of 101 cases contained in the casebook was analysed by adopting a Gadamerian approach to hermeneutics. RESULTS: The examination of the institute's casebook identified several broad themes relating to the children's admittance, daily life at the institute and their routes out of the institute. The study also extols the individuality of each child's life story to provide an awareness and richer appreciation of the humanness and personhood of the children. CONCLUSION: The article contributes a positive narrative to the identity and the history of South African children with intellectual disability living in the late 19th and early 20th centuries.

How the Realism of Robot Is Needed for Individuals With Autism Spectrum Disorders in an Interview Setting.

The preliminary efficacy of interview training using an android robot whose appearance and movements resemble those of an actual human for treating social and communication difficulties in individuals with autism spectrum disorders (ASD) has been demonstrated. Patient preferences regarding the appearance of robots are crucial for incentivizing them to undergo robot-assisted therapy. However, very little is known about how the realistic nature of an android robot is related to incentivizing individuals with ASD in an interview setting. In this study, individuals with ASD underwent an interview with a human interviewer and an android robot. Twenty-three individuals with ASD (age, 17-25 years) participated in this study. After the interview, the participants were evaluated in terms of their motivation to practice an interview with an android robot and their impression of the nature of the android robot in terms of humanness. As expected, subjects exhibited higher motivation to undergo interview training with an android robot than with a human interviewer. Higher motivation to undergo an interview with the android robot was negatively correlated with the participants' impressions of the extent to which the android robot exhibited humanness. This study brings us one step closer to understanding how such an android robot should be designed and implemented to provide sufficiently realistic interview training that can be of therapeutic value.

The effects of ethnic group membership on bullying at school: when do observers dehumanize bullies?

The purpose of this experiment was to test how ethnic group membership of both the bullies and the victims influence the way that observers attribute human characteristics to bullies. Ethnic group membership was manipulated in terms of bullies' and victims' ethnicity (ingroup-majority group versus outgroup-minority group). Furthermore, we examined the mediating role of empathic concern towards the victim and perspective taking of the bully in the relation between ethnic group membership of bullies and victims and attributions of humanness to the bullies. We hypothesized that observers would attribute lower human characteristics to outgroup bullies when bullies inflict harm on an ingroup victim. Moreover, we expected that perspective taking of the bully and empathic concern towards the victim would mediate this relation. Analysis of data from a sample of 293 Greek-Cypriot adolescents fully corroborated our hypotheses. The findings are discussed in terms of the discrimination-based nature of bullying at school.

From 'automation' to 'autonomy': the importance of trust repair in human-machine interaction.

Modern interactions with technology are increasingly moving away from simple human use of computers as tools to the establishment of human relationships with autonomous entities that carry out actions on our behalf. In a recent commentary, Peter Hancock issued a stark warning to the field of human factors that attention must be focused on the appropriate design of a new class of technology: highly autonomous systems. In this article, we heed the warning and propose a human-centred approach directly aimed at ensuring that future human-autonomy interactions remain focused on the user's needs and preferences. By adapting literature from industrial psychology, we propose a framework to infuse a unique human-like ability, building and actively repairing trust, into autonomous systems. We conclude by proposing a model to guide the design of future autonomy and a research agenda to explore current challenges in repairing trust between humans and autonomous systems. Practitioner Summary: This paper is a call to practitioners to re-cast our connection to technology as akin to a relationship between two humans rather than between a human and their tools. To that end, designing autonomy with trust repair abilities will ensure future technology maintains and repairs relationships with their human partners.

Impressions of Humanness for Android Robot may Represent an Endophenotype for Autism Spectrum Disorders.

Identification of meaningful endophenotypes may be critical to unraveling the etiology and pathophysiology of autism spectrum disorders (ASD). We investigated whether impressions of "humanness" for android robot might represent a candidate characteristic of an ASD endophenotype. We used a female type of android robot with an appearance similar to that of a real person. Significant differences in overall impressions of 'humanness' for android robot were found between adolescents with ASD and typical development (TD) controls, as well as parents of children with ASD and parents of TD controls. Our current work does suggest robotic systems could potentially play an intelligent role in dissecting ASD heterogeneity.