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J Obstet Gynaecol Can ; 45(4): 283-293.e2, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-37149340


OBJECTIF: Évaluer les risques et bénéfices de la chirurgie minimalement invasive dans la prise en charge des patientes atteintes d'infertilité et fournir des conseils aux gynécologues qui prennent en charge les problèmes les plus fréquents chez ces patientes. POPULATION CIBLE: Patientes atteintes d'infertilité (incapacité à concevoir après 12 mois de rapports sexuels non protégés) en processus diagnostique ou sous traitement. BéNéFICES, RISQUES ET COûTS: On peut recourir à la chirurgie de la reproduction minimalement invasive pour traiter l'infertilité, améliorer les résultats des traitements de fertilité ou préserver la fertilité. Toutes les interventions chirurgicales comportent des risques et des complications associées. La chirurgie de la reproduction n'améliore pas toujours la fertilité et peut, dans certains cas, compromettre la réserve ovarienne. Toutes les interventions entraînent des coûts, lesquels sont assumés par la patiente ou son assureur. DONNéES PROBANTES: Des recherches ont été faites dans les bases de données PubMed-Medline, Embase, Science Direct, Scopus et Cochrane Library pour répertorier les articles publiés en anglais dans la période de janvier 2010 à mai 2021 (voir les termes de recherche MeSH à l'annexe A). MéTHODES DE VALIDATION: Les auteurs ont évalué la qualité des données probantes et la force des recommandations en utilisant le cadre méthodologique GRADE (Grading of Recommendations Assessment, Development and Evaluation). Voir l'annexe B en ligne (tableau B1 pour les définitions et tableau B2 pour l'interprétation des recommandations fortes et conditionnelles [faibles]). PROFESSIONNELS CONCERNéS: Gynécologues qui prennent en charge les affections courantes chez les patientes atteintes d'infertilité. DÉCLARATIONS SOMMAIRES: RECOMMANDATIONS.

Ann Pathol ; 2023 May 16.
Artigo em Francês | MEDLINE | ID: mdl-37202297


Peritoneal inclusion cyst is a rare benign tumor. It usually affects women of reproductive age. Its etiology is poorly understood; a history of endometriosis, pelvic inflammatory disease and pelvic surgery are sometimes implicated in its occurrence. Its diagnosis is difficult with complex management. We report the case of a 29-year-old woman presenting a rectal mass for which the analysis of echo-endoscopic samples was not contributory. The PET-scan revealed a rectal submucosal mass and deep adenopathy. An exploratory laparoscopy was performed, and allowed to remove cystic inflammatory areas and lymph nodes. The histopathological study confirmed the diagnosis of peritoneal inclusion cyst with endometriosis and reactive adenitis. Peritoneal inclusion cyst is a rare condition that develops at the expense of the serosa. The risk of recurrence is high with a possibility of malignant transformation. Excision and monitoring are essential for good management.

Artigo em Francês | MEDLINE | ID: mdl-37080293


OBJECTIVE: Preoperative assessment of rectal damage in digestive endometriosis requires rectal endoscopic ultra-sonography an invasive exam that is not well received by the patients. A standardized approach using an Ultrasound-Based Endometriosis Staging System (UBESS)could be an interesting tool in this indication. This article aims to evaluate the performance of UBESS in the prediction of rectal involvement and the type of surgical procedure. MATERIALS AND METHODS: This monocentric retrospective study was conducted on patients with rectal endometriosis who underwent a curative surgical procedure, evaluated by UBESS ultrasound between January 2016 and December 2019 at the Poissy referral centre. The main analysis of the study was to assess the adequacy of the UBESS ultrasound stage, the presence of rectal involvement during surgery and the surgical technique required. The secondary objective was to determine the correlation between UBESS stages and RCOG levels of surgical difficulty. RESULTS: A total of one hundred and twenty-two patients were included and one hundred were analysed. Of these, thirty-nine had rectal involvement. There was a statistically significant association between the UBESS stage and the presence of a digestive lesion(P<0.0001). The ultrasound's parameters of thickness(P=0.0007), width(P=0.0082) and volume(P=0.0013) of the digestive lesion were significantly correlated with the extent of the surgical procedure. The correlation between the UBESS and RCOG classifications was very weak. CONCLUSION: UBESS is a powerful diagnostic tool for digestive damage allowing to give clear information to patients before surgery and optimizing the management plan of the surgery.

Med Anthropol ; 42(2): 136-148, 2023 02 17.
Artigo em Inglês | MEDLINE | ID: mdl-36745574


Medical egg freezing (MEF) allows women with fertility-threatening diseases to have their oocytes cryopreserved and stored for later use. Endometriosis is a common gynecological disease that might cause infertility. Qualitative research on endometriosis patients' experiences with MEF is minimal. I report on in-depth interviews among French endometriosis patients undertaking MEF. Their experiences are profoundly shaped by endometriosis-related pain. Egg freezing was described as a disease management strategy to cope with potential future infertility integral to their commitment to motherhood. Singlehood was a determining element for agreeing to undertake a physically and psychologically costly "additional" medical intervention.

Endometriose , Preservação da Fertilidade , Infertilidade , Feminino , Humanos , Endometriose/terapia , Antropologia Médica , Criopreservação
Gynecol Obstet Fertil Senol ; 51(2): 111-116, 2023 Feb.
Artigo em Francês | MEDLINE | ID: mdl-36623707


OBJECTIVES: A significant proportion of women with suspected endometriosis present neuropathic pain. The aim of this study is to assess this prevalence and the relevance of specific tests used. METHODS: This is a single-center retrospective study in the CHI of Poissy Saint Germain en Laye with patients who were referred for suspected endometriosis and who benefited from evaluation of neuropathic pain by two distinct questionnaires. The PAINdetect was evaluated by a series of 7 questions scored from 0 to 5 with a positive test if score>18. For the DN4, 7 binary questions were asked and 3 other questions were related to the clinical examination with a positivity threshold reached if score≥4 and in the absence of clinical examination if score≥3. RESULTS: From November 2020 to June 2022, 57 patients were examined with a prevalence of neuropathic pain (one of the two test positive) evaluated at 36.8%. PAINdetect and DN4 positivity rates were at 26.8% and 30.9%. A discordance was found in 14.8% of cases with a kappa coefficient calculated at 0.63. There was a significant association between radiological examination and neuropathic pain with more neuropathic pain when the radiological examination was negative (P=0.03). The myofascial syndrome was present in only 59.5% of the patients and wasn't associated with neuropathic pain (P=1.00). CONCLUSION: Prevalence of neuropathic pain in case of suspected endometriosis appears to be high. This need to be confirmed in a multicenter study with also assessment of the validity of the two diagnostic tests.

Endometriose , Neuralgia , Humanos , Feminino , Estudos Retrospectivos , Endometriose/complicações , Endometriose/diagnóstico , Endometriose/epidemiologia , Medição da Dor , Neuralgia/diagnóstico , Neuralgia/epidemiologia , Inquéritos e Questionários
Artigo em Francês | MEDLINE | ID: mdl-36423880


INTRODUCTION: The diagnosis of endometriosis is often difficult to make, generating a median diagnostic delay ranging from 2 to 10.7 years. A study of the care pathway of these patients seems essential in order to evaluate the diagnostic delay of endometriosis in France and the factors related to the diagnostic delay. METHODS: This is a prospective multicenter study, conducted between 2017 and 2019. A questionnaire concerning their care pathway and their feelings about the diagnosis was distributed to all patients consulting for endometriosis. Statistical analyses were performed using the Kruskal-Wallis, Chi2 and Student's t tests. RESULTS: 57 of the 84 patients (67.8%) who completed the questionnaire were included in the evaluation of diagnostic delays. The total diagnostic delay was 12 years (min 0; max 33) and was comparable between all inclusion cities (p=0.68). Regarding the care pathway according to specialties, the diagnosis of endometriosis was made by gynecologists in 81% of patients versus 19% by general practitioners. The time between the onset of symptoms and the first consultation was significantly shorter in favor of the general practitioner (2 years versus 4 years, p=0.012). 60% of the patients reported that their symptoms were labelled as "normal" by the physicians and 35% of them considered them normal themselves. CONCLUSION: Our study showed that the delay in diagnosis in France was still very long and that the mechanisms of the delay in management were multifactorial. Awareness raising and training of health care providers remains one of the major areas to be optimized.

Rev. bras. ginecol. obstet ; 44(11): 1040-1046, Nov. 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1423271


Abstract Objective The purpose was to assess the rates of postoperative complications and the need of temporary stoma of laparoscopic surgical treatment for bowel endometriosis in a referral center. Methods The surgical indication, type of operation, operative time, length of hospital stay, need for a temporary stoma, rate of conversion to open surgery, postoperative complications were evaluated. Results One-hundred and fifty patients were included. The average duration of surgery was significantly longer for segmental resection (151 minutes) than for disc excision (111.5 minutes, p < 0.001) and shaving (96.8 minutes, p < 0.001). Patients with segmental resection had longer postoperative lengths of hospital stay (1.87 days) compared with patients with disc excision (1.43 days, p < 0.001) and shaving (1.03 days, p < 0.001). A temporary stoma was performed in 2.7% of patients. Grade II and III postoperative complications occurred in 6.7% and 4.7% patients, respectively. Conclusion Laparoscopic intestinal resection has an acceptable postoperative complication rate and a low need for a temporary stoma.

Resumo Objetivo O objetivo foi avaliar as taxas de complicações pós-operatórias e a necessidade de estomia temporária do tratamento cirúrgico laparoscópico para endometriose intestinal em um centro de referência. Métodos Foram avaliados a indicação cirúrgica, tipo de operação, tempo operatório, tempo de internação, necessidade de estomia temporária, taxa de conversão para cirurgia aberta, complicações pós-operatórias. Resultados Cento e cinquenta pacientes foram incluídos. A duração média da cirurgia foi significativamente maior para a ressecção segmentar (151 minutos) do que para a excisão do disco (111,5 minutos, p < 0,001) e shaving (96,8 minutos, p < 0,001). Pacientes com ressecção segmentar tiveram maior tempo de internação pós-operatória (1,87 dias) em comparação com pacientes com excisão de disco (1,43 dias, p < 0,001) e shaving (1,03 dias, p < 0,001). Um estoma temporário foi realizado em 2,7% dos pacientes. Complicações pós-operatórias de grau II e III ocorreram em 6,7% e 4,7% dos pacientes, respectivamente. Conclusão A ressecção intestinal laparoscópica apresenta taxa aceitável de complicações pós-operatórias e baixa necessidade de estomia temporária.

Gynecol Obstet Fertil Senol ; 50(12): 762-769, 2022 12.
Artigo em Francês | MEDLINE | ID: mdl-36183984


OBJECTIVE: Assessment of the practices and knowledge of general practitioners in the south of France regarding the diagnosis and management of endometriosis. METHOD: A descriptive cross-sectional study was conducted among general practitioners in the south of France from November 14, 2021 to February 14, 2022. A questionnaire was developed in consultation with and validated by two university endometriosis reference services of the AP-HM and was sent to general practitioners practicing in the south of France. It was distributed via professional emails, care networks and the south of France's medical order. The questionnaire was divided into three parts: the first simply collected demographic and epidemiological data, the second assessed knowledge of the disease, and the last assessed individual practices. The primary endpoint was the percentage of practitioners with>75% correct responses. RESULTS: 133 general practitioners responded to the questionnaire (133/407, 32.1%). 60.2% performed more than one gynecological consultation per week. 61.7% obtained a rate of correct answers>75%. The general practitioners with the best response rates were more aware of the latest HAS guidelines (P=0.027) and performed gynecological consultations more regularly in the office (P=0.025). Intense dysmenorrhea, chronic pelvic pain and deep dyspareunia were considered as evocative by 98.1%, 95.5% and 95.5% of respondents respectively. On the other hand, uro-digestive disorders were not often mentioned. In case of suspicion of endometriosis on questioning, 54.9% of general practitioners performed a clinical gynaecological examination. 76.7% prescribed an imaging test and 32.3% introduced hormonal treatment during the consultation. Referral of patients to specialists was made by the general practitioner as soon as clinical suspicion arose for 36.8%. CONCLUSION: The results of our study suggest that the knowledge and practices of general practitioners, performing gynecology consultations in the south of France, is perfectible. In the context of the announcement of a regional reorganization of endometriosis-related care, other similar studies should be conducted regularly in order to assess the evolution of general practitioner's practices.

Endometriose , Clínicos Gerais , Feminino , Humanos , Endometriose/diagnóstico , Endometriose/terapia , Estudos Transversais , Encaminhamento e Consulta , Inquéritos e Questionários , França
Arq. ciências saúde UNIPAR ; 26(2): 107-112, maio-ago. 2022.
Artigo em Português | LILACS | ID: biblio-1372953


O objetivo deste estudo é apresentar uma revisão atualizada sobre o papel dos polimorfismos genéticos na etiologia da endometriose. Trata-se de uma pesquisa bibliográfica feita no PubMed utilizando os descritores "polymorphism and endometriosis". Foram identificados 36 artigos e após aplicação dos critérios de inclusão foram selecionados 17 artigos para a amostra final. Os principais resultados foram: 1) cerca de 60% dos artigos foram publicados em 2019; 2) em 35,3% dos estudos o número de casos e controles investigados foi menor que 100; 3) a maioria dos trabalhos investigou de um a dois polimorfismos por gene; 4) a produção científica sobre endometriose é maior em países orientais; 5) houve heterogeneidade quanto aos periódicos onde os trabalhos foram publicados; 6) as principais técnicas para detecção de polimorfismos foi a PCR-RFLP e o PCR em tempo real, com frequências semelhantes. Em suma, os polimorfismos genéticos podem estar implicados na etiologia da endometriose.

The aim of this study is to present an updated review on the role of genetic polymorphisms in the etiology of endometriosis. This is a literature review made on PubMed using the descriptors "polymorphism and endometriosis". A total 36 articles were identified and, after applying the inclusion criteria, 17 articles were selected for the final sample. The main results were: 1) approximately 60% of the articles were published in 2019; 2) 35.3% of the studies investigated less than 100 cases and controls; 3) most studies investigated one to two polymorphisms per gene; 4) scientific production on endometriosis is higher in Eastern countries; 5) heterogeneity was observed regarding the journals where works were published; 6) the main techniques for detecting polymorphisms were PCR-RFLP and real-time PCR, with similar frequencies. In summary, it can be concluded that genetic polymorphisms may be implicated in the etiology of endometriosis.

Humanos , Feminino , Polimorfismo Genético , Endometriose/diagnóstico , Biomarcadores , Reação em Cadeia da Polimerase , Infertilidade Feminina/diagnóstico
Rev. bras. ginecol. obstet ; 44(5): 503-510, May 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1387910


Abstract Objectives To evaluate the impact of surgical treatment of deep infiltrative endometriosis (DIE) on pelvic floor dysfunction (urinary incontinence [UI], pelvic organ prolapse [POP], fecal incontinence [FI)] or constipation, and sexual function [dyspareunia]). Data Source The present systematic review was performed in the PubMed database. For the selection of studies, articles should be published by January 5, 2021, without language restriction. Study Selection Six randomized controlled studies that evaluated surgical treatment for DIE and the comparison of different surgical techniques were included. Data Collection The studies were selected independently by title and abstract by two authors. Disagreements were resolved by a third author. All included studies were also evaluated according to the Cochrane risk of bias tool and the quality of the evidence was analyzed using the GRADE criteria. Subgroup analysis by different treatments and follow-up periods was also performed. Results Six studies were included in the quantitative analysis. The risk of bias between studies showed an uncertain risk of bias for most studies, with concealment of allocation being the least reported category. The quality of the evidence was considered low. High heterogeneity was found between the studies. No study has evaluated UI or POP comparatively before and after surgery. Conclusion Dyspareunia and FI have improved after the surgical procedure, but it was not possible to demonstratewhich surgical technique was related to these outcomes as there was surgical heterogeneity. This diversity was found across data, with the recommendation of future prospective studies addressing pelvic floor disorders withDIE.

Resumo Objetivos Avaliar o impacto do tratamento cirúrgico para endometriose infiltrante profunda (EIP) nas disfunções do assoalho pélvico (incontinência urinária [IU], prolapso de órgãos pélvicos [POP], incontinência fecal [IF] ou constipação e função sexual [dispareunia]). Fonte de Dados A presente revisão sistemática foi realizada na base de dados PubMed. Para a seleção dos estudos, os artigos deveriam ser publicados até 5 de janeiro de 2021, sem restrição de idioma. Seleção dos Estudos Foram incluídos seis estudos randomizados e controlados que avaliaram o tratamento cirúrgico para EIP e a comparação de diferentes técnicas cirúrgicas. Coleta de Dados Os estudos foram selecionados de forma independente por título e resumo por dois autores. As discordâncias foram avaliadas por umterceiro autor. Todos os estudos incluídos foram avaliados de acordo coma ferramenta Cochrane de risco de viés e a qualidade de evidência foi analisada usando os critérios GRADE. A análise de subgrupo por diferentes tratamentos e períodos de acompanhamento também foi realizada. Resultados Seis estudos foram incluídos na análise quantitativa. O risco de viés mostrou um risco incerto de viés para a maioria dos estudos, sendo a ocultação da alocação a categoria menos relatada. A qualidade de evidência foi considerada baixa. Alta heterogeneidade foi encontrada entre os estudos. Nenhum estudo avaliou a IU ou o POP comparativamente antes e após a cirurgia. Conclusão A dispareunia e a IF melhoraram após o procedimento cirúrgico, mas não foi possível demonstrar qual técnica cirúrgica esteve relacionada a estes desfechos, pois houve heterogeneidade cirúrgica. Esta diversidade foi encontrada nos dados, com a recomendação de estudos prospectivos futuros abordando distúrbios do assoalho pélvico com EIP.

Prog Urol ; 32(7): 487-497, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35249825


INTRODUCTION: This randomized, crossover, double-blind, controlled trial evaluates the efficacy and safety of a preprogrammed transcutaneous electrical nerve stimulation (TENS) device versus placebo (SHAM) in women with primary dysmenorrhea (PD). MATERIAL: Forty women suffering from significant dysmenorrhea requiring the use of analgesics and/or non-steroidal anti-inflammatory drugs self-apply to the abdominal or lumbar region depending on the location of the pain, alternately according to randomization, the TENS device then the SHAM (dummy device) or conversely SHAM then TENS. The primary endpoint compares the evolution of pain intensity before and after application of TENS and SHAM. The speed of action, the persistence of the analgesic effect and the therapeutic savings are also evaluated. Adverse events (AEs) are collected. RESULTS: A statistically and clinically significant decrease in the pain of 53% (P<0.0001) is observed during the first 2 applications of TENS versus no analgesic effect (-5%, P=0.318) with SHAM. Over all 197 applications of TENS, the reduction of menstrual pain intensity by more than half is confirmed. The rapid relief, less than 20 minutes in 74% of cases, lasts on average more than 7 hours. A difference in analgesic consumption of -93% is observed in favor of TENS (P<0.01). Seven participants reported 10 non-serious AEs, 2 of which were possibly related to TENS. CONCLUSION: The TENS device tested represents a well-tolerated, rapidly and lastingly effective non-pharmacological analgesic solution, capable of replacing or being combined with analgesics in the management of PD.

Dismenorreia , Estimulação Elétrica Nervosa Transcutânea , Analgésicos/uso terapêutico , Método Duplo-Cego , Dismenorreia/terapia , Feminino , Humanos , Medição da Dor , Resultado do Tratamento
Rev. bras. ginecol. obstet ; 44(3): 295-303, Mar. 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1387872


Abstract Introduction Endometriosis is an inflammatory disease that affects women of reproductive age, causing pain and the possibility of infertility. Endometriosis was associated to low life quality and research shows the impact of endometriosis in several areas of life, justifying how these patients are more likely to develop depression, anxiety, and stress. Objective The aim of the present systematic review was to explore the field of psychology in endometriosis, identifying studies that used the cognitive behavioral therapy technique as a treatment for endometriosis and chronic pelvic pain. Methods The keywords used were Endometriosis and Behavioral Therapy; Behavioral Disciplines and Activities; Cognitive Behavioral Therapy; Mental Health; Psychological Techniques; Psychology; Psychotherapy; Mental Health Services; and the search was performed in the following databases: PubMed/Medline, Scielo, Lilacs, and Capes. The study followed the PRISMA guidelines and all studies whose intervention strategy used was related to cognitive-behavioral therapy were considered. Results Of the 129 articles found, only 5 were selected, and it was possible to identify that the psychological intervention whose approach brought cognitive-behavioral therapy techniques promoted a decrease in the sensation of pain, improvements in the scores of depression and stress, and significant changes in aspects of quality of life such as vitality, physical and social functioning, emotional well-being, control, and autonomy. Conclusion Cognitive-behavioral therapy can be very promising to take care of the emotional side of those who have endometriosis However, the present systematic review highlights the need to develop more structured studies with consistent, clear and replicablemethods to reach a psychological intervention protocol for patients who live with this gynecological-physical-emotional condition.

Resumo Introdução A endometriose é uma doença inflamatória que afeta mulheres em idade reprodutiva, causando dor e possibilidade de infertilidade. A endometriose foi associada a baixa qualidade de vida e pesquisas mostram o impacto da endometriose emdiversas áreas da vida, justificando como tais pacientes têmmaior probabilidade de desenvolver depressão, ansiedade e estresse. Objetivo O objetivo da presente revisão sistemática foi explorar o campo da psicologia na endometriose, identificando estudos que usaram a técnica da terapia cognitiva comportamental como tratamento da endometriose e da dor pélvica crônica. Métodos As palavras chaves utilizadas foram Endometriose AND Terapia comportamental; Disciplinas e atividades comportamentais; Terapia cognitiva comportamental; Saúde mental; Técnicas psicológicas; Psicologia; Psicoterapia; Serviços de saúde mental, e a busca foi realizada nos bancos de dados PubMed / Medline, SCIELO, LILACS e CAPES. O estudo seguiu as diretrizes dos Principais Itens para Relatar Revisões Sistemáticas e Metanálises (PRISMA, na sigla em inglês) e foram considerados todos os estudos cuja estratégia de intervenção utilizada estava relacionada à terapia cognitivocomportamental. Resultados Dos 129 artigos encontrados, somente 5 foram selecionados, e foi possível identificar que a intervenção psicológica cuja abordagem trouxe técnicas da terapia cognitivo-comportamental promoveu diminuição na sensação de dor, melhora nos escores de depressão e estresse e mudanças significativas em aspectos da qualidade de vida como vitalidade, funcionalidade física e social, bem-estar emocional, controle e autonomia. Conclusão A terapia cognitivo-comportamental pode ser muito promissora para o tratamento psicológico/emocional de quem tem endometriose. No entanto, a presente revisão sistemática destaca a necessidade de desenvolver estudos mais estruturados com métodos consistentes, claros e replicáveis para se chegar a um protocolo de intervenção psicológica para pacientes que convivem com esse quadro ginecológico-físico-emocional.

Rev. Assoc. Méd. Rio Gd. do Sul ; 66(1): 01022105, 20220101.
Artigo em Português | LILACS | ID: biblio-1424991


Introdução: Endometriose é uma doença estrogênio dependente caracterizada pela presença e crescimento de glândulas endometriais e estroma fora da cavidade uterina. A abordagem laparoscópica é o padrão ouro para o diagnóstico de endometriose, porém trata-se de um método invasivo. Atualmente, a Ressonância Nuclear Magnética (RNM) vem sendo usada como uma ferramenta para solução de problemas em casos de achados anexiais indeterminados na ultrassonografia, quando há suspeita de endometriose profunda infiltrativa ou para mapeamento pré-cirúrgico. Objetivo: Avaliar o perfil clínico e o uso da RNM em pacientes com suspeita de endometriose em uma clínica de diagnósticos por imagem em Criciúma/SC. Métodos: Trata-se de um estudo observacional, retrospectivo, descritivo, com coleta de dados secundários e abordagem quantitativa. Resultados: Analisaram-se 181 pacientes. A média de idade foi de 34,18 anos. 91,7% apresentavam exames anteriores, sendo o mais relatado à ultrassonografia transvaginal (73,5%). O sintoma mais referido foi dor abdominal pélvica (56,9%). O achado mais comum à RNM foi espessamento do ligamento uterossacro (57,5%). Não houve relação estatística entre os sintomas e seus achados à RNM. A média de idade foi estatisticamente maior nas mulheres sem dor pélvica, sem irregularidade menstrual, e com dor abdominal não pélvica. Conclusão: As manifestações clínicas dor pélvica, dor abdominal não pélvica e irregularidade menstrual foram os dados que se mostraram estatisticamente significativos quando comparados com a média de idade de aparecimento dos sinais e sintomas em pacientes com suspeita de endometriose. Por se tratar de uma doença com aspectos variados, torna-se imprescindível entender o perfil clínico e sua avaliação, objetivando-se contribuir com o avanço do conhecimento da doença.

Introduction: Endometriosis is an estrogen-dependent disease characterized by the presence and growth of endometrial glands and stroma outside the uterine cavity. The laparoscopic approach is the gold standard to diagnose endometriosis, but it is an invasive procedure. Currently, nuclear magnetic resonance imaging (NMRI) has been used as a tool to solve problems in cases of indeterminate adnexal findings on ultrasonography, when there is suspicion of deeply infiltrating endometriosis or for pre-surgical mapping. Objective: To assess the clinical profile and use of NMRI in patients with suspected endometriosis in a diagnostic imaging clinic of the municipality of Criciúma, state of Santa Catarina, Brazil. Methods: This is a descriptive, observational, retrospective study with collection of secondary data and quantitative approach. Results: A total of 181 patients were analyzed. Mean age was 34.18 years. Moreover, 91.7% of patients had previous exams, the most frequent of which was vaginal ultrasonography (73.5%). The most reported symptom was pelvic abdominal pain (56.9%). The most common NMRI finding was uterosacral ligament thickening (57.5%). There was no statistical relationship between symptoms and NMRI findings. Mean age was statistically higher in women without pelvic pain, with no menstrual Irregularities, and with non-pelvic abdominal pain. Conclusions: Clinical manifestations pelvic pain, non-pelvic abdominal pain and menstrual irregularity were the data that were statistically significant when compared with the mean age of onset of signs and symptoms in patients with suspected endometriosis. Since this disease has varied aspects, it is essential to understand and evaluate patients' clinical profile, in order to contribute to advances in disease knowledge.

Rev Mal Respir ; 39(3): 221-227, 2022 Mar.
Artigo em Francês | MEDLINE | ID: mdl-35219560


OBJECTIVE: To report our therapeutic approach toward catamenial hemothorax. PATIENTS AND METHODS: This retrospective study from January 1994 to November 2018 concerned patients operated under general anesthesia for catamenial hemothorax. A posterolateral thoracotomy approach was implemented either directly or after primary videothoracoscopy. Six-month hormone therapy was systematically prescribed postoperatively. The result was assessed in terms of occurrence or non-occurrence of hemothorax upon resumption of menses after discontinuation of hormone therapy. RESULTS: Eleven patients were selected, with an average age was 32years (25-41). Catamenial hemothorax was associated with hemorrhagic ascites in 5 cases. Endometriotic plaques in the form of diaphragmatic fenestrations were found nine times and were resected (1 case) or covered by a synthetic non-absorbable patch (8 cases). Pleural symphysis completed the surgical procedures. The one hormone used was triptorelin. Mortality was zero. Mean postoperative hospital stay was 10.24days and mean follow-up was 3.5years. One patient was lost to follow-up at 3months. One hemothorax recurrence was observed after discontinuation of hormone therapy at 4months [1], and repeated pleural punctures were carried out while awaiting revision surgery. The five cases of ascites recurred and the patients were monitored in the gynecology unit. CONCLUSION: In patients suffering from catamenial hemothorax with diaphragmatic fenestrations, we recommend phrenoplasty using synthetic patches associated with pleural talcage and 6-month complementary concomitant hormone therapy.

Hemotórax , Pneumotórax , Adulto , Ascite/complicações , Feminino , Hemotórax/complicações , Hemotórax/cirurgia , Hormônios , Humanos , Pneumotórax/terapia , Recidiva , Estudos Retrospectivos
Gynecol Obstet Fertil Senol ; 50(1): 69-74, 2022 Jan.
Artigo em Francês | MEDLINE | ID: mdl-34656789


AIM: Endometriosis is a disabling gynecological pathology. Couples who face it frequently encounter sexual difficulties related to dyspareunia. This study aims to understand the sexual experiences of endometriosis patients and their partners. METHODS: A total of 13 patients and 13 partners were interviewed prior to surgery. Semi-structured interviews were conducted separately and explored their sexual experiences. The interviews were transcribed verbatim and analyzed using content analysis. RESULTS: Both members of the couple reported pain during intercourses; decreased sexual desire; adaptation during sexual intercourses; communication about sexuality, which can be either open or a source of conflict, and the search for explanations for endometriosis. As for the emotional sphere, patients report anticipatory anxiety while partners report frustration and hope. CONCLUSION: These couples are in difficulty regarding sexuality, it is necessary to take care of both members of the couple and to encourage communication between them.

Dispareunia , Endometriose , Dispareunia/etiologia , Endometriose/complicações , Feminino , Humanos , Comportamento Sexual/psicologia , Parceiros Sexuais/psicologia , Sexualidade/psicologia
Fisioter. Mov. (Online) ; 35: e35124, 2022. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1384942


Abstract Introduction: Endometriosis is a disorder that can significantly affect quality of life (QOL) and interfere in biological, psychological, social, marital and family aspects. Objective: To analyze the influence of endometriosis on the QOL of women diagnosed with the disease. Methods: The study was carried out from March to April 2018, with 10 volunteers from the Santa Casa de Misericórdia do Pará Foundation, with a clinical diagnosis of endometriosis. The Portuguese version of the endometriosis health profile questionnaire (EHP-30) was applied in order to assess QOL in women with this pathology. Results: The sociodemographic results revealed a predominance of women aged between 29 and 55 years, most of whom were married (6) and high school graduates (5). Seven of the ten volunteers had previous pregnancies. Of the aspects evaluated in the EHP-30, 79% of the items associated with pelvic pain in the core questionnaire were present in the participants. In other questionnaires, sexual life (82%) was the most affected index, followed by professional life (70%) and infertility (58.82%). Conclusion: The aspects of QOL most impacted by pelvic pain associated with endometriosis in the women evaluated were sexuality and professional life, leading to biopsychosocial trauma.

Resumo Introdução: A endometriose é um distúrbio que pode atingir amplamente a qualidade de vida (QV) e interferir no âmbito biológico, psicológico, social, marital e familiar. Objetivo: Analisar a influência da endometriose na QV de mulheres portadoras dessa patologia. Métodos: O estudo foi realizado no período de março a abril de 2018, com dez voluntárias da Fundação Santa Casa de Misericórdia do Pará, que apresentavam diagnóstico clínico de endometriose. Aplicou-se o Questionário de Qualidade de vida em Endometriose (EHP-30), versão em português, a fim de avaliar a QV em mulheres com endometriose. Resultados: Os resultados sociodemográficos mostra-ram uma predominância de mulheres com idade entre 29 e 55 anos, sendo a maioria casada (6) e com colegial completo (5). Sete das dez voluntárias tiveram gestações. Dentre os âmbitos avaliados pelo EHP-30, o questionário central de QV relacionado à dor pélvica teve 79% dos itens comprometendo as participantes. Nos demais questionários, a vida sexual (82%) foi o índice mais afetado, seguido da vida profissional (70%) e infertilidade (58,82%). Conclusão: Nas mulheres avaliadas, os aspectos da QV mais influenciados pela dor pélvica relacionada à endometriose foram a sexualidade e a vida profissional, acarretando prejuízos biopsicossociais.

Cad. Saúde Pública (Online) ; 38(2): e00226320, 2022. graf
Artigo em Inglês | LILACS | ID: biblio-1360278


Abstract: The topics of endometriosis and pain imply far-reaching problems for women's health. Using a qualitative research approach, this paper addresses the subjective experience and effects of pain, the methods for dealing with these issues, and the needs of affected women in Austria. Data were collected by problem-focused interviews conducted with ten women suffering from endometriosis, which were later transcribed and subjected to qualitative content analysis. Findings are therefore described using content-related categories. Results show that negative thoughts and feelings like fear, despair, and anger are associated with endometriosis and pain. Moreover, predominantly negative impacts and changes are found in various areas of life, such as the well-being and psyche of those affected, their attitude towards life in general, partnerships, social life, leisure time and work-life balance. In dealing with endometriosis and pain, both Western biomedicine and complementary medicine treatments are used. Support from one's inner circle of friends and exchange and interaction with others affected by the disease are seen to be invaluable. Attending physicians as well as patients themselves and their private, social, and working environment should encourage open communication about endometriosis and the related pain.

Resumo: O tema da endometriose e dor tem implicações relevantes para a saúde das mulheres. O artigo procura contextualizar a experiência subjetiva e os efeitos da dor, os métodos para lidar com essas questões e as necessidades das mulheres afetadas por essa condição na Áustria. Foi escolhida uma abordagem qualitativa para examinar esses temas. Foram realizadas entrevistas focadas em problemas com dez mulheres com história de endometriose. Após a transcrição do material, foi realizada a análise qualitativa do conteúdo. Assim, os achados são retratados com o uso de categorias relacionadas ao conteúdo. Os resultados mostram que pensamentos e sentimentos negativos como medo, desesperança e raiva estão associados com a endometriose e dor. Além disso, são encontrados impactos e mudanças predominantemente negativos em vários domínios da vida, tais como o bem-estar e o estado psicológicos das mulheres afetadas, a atitude geral em relação à vida, parcerias, vida social, tempo de lazer e equilíbrio entre trabalho e vida pessoal. Tanto a medicina ocidental quanto os tratamentos da medicina complementar são utilizados no manejo da endometriose e da dor. O apoio do círculo próximo de amigas e as trocas e interação com outras pessoas afetadas pela doença são vistos como extremamente úteis. Os médicos atendentes e as próprias pacientes e seus ambientes privados, sociais e laborais devem incentivar a comunicação aberta sobre a endometriose e a dor associada.

Resumen: La endometriosis y su dolor asociado implican problemas profundos para la salud de las mujeres. El objetivo de este trabajo es identificar la experiencia subjetiva y los efectos del dolor, los métodos para tratarlos, así como las necesidades de las mujeres afectadas en Austria. Para el examen de los temas mencionados anteriormente, se eligió un enfoque de investigación cualitativo. Las entrevistas enfocadas en los problemas se realizaron con diez mujeres que sufrían endometriosis. Tras la transcripción material de los datos, el análisis se realizó usando un análisis cualitativo de contenido. Por lo tanto, los resultados se describen usando categorías relacionadas con el contenido. Los resultados muestran que los pensamientos negativos y los sentimientos como miedo, desesperación, y enfado están conectados con la endometriosis y el dolor. Además, predominantemente se encontraron impactos negativos y cambios en varias áreas de la vida, tales como: bienestar, psique de quienes se veían afectadas, su actitud ante la vida en general, relaciones, vida social, equilibrio entre tiempo de ocio y trabajo. Para enfrentarse a la endometriosis y el dolor, se utilizan tratamientos biomédicos occidentales, así como medicina complementaria. El apoyo del círculo íntimo de los afectados, como son los amigos, así como el intercambio e interacción con otras personas afectadas por la enfermedad parecen ser muy útiles. Ir al médico, el entorno privado, social y laboral de las pacientes, así como ellas mismas, deben estar y ser animadas para una comunicación abierta sobre la endometriosis y el dolor relacionado con la misma.

Endometriose/complicações , Endometriose/terapia , Dor/etiologia , Qualidade de Vida , Áustria , Brasil , Pesquisa Qualitativa
Ann. afr. méd. (En ligne) ; 15(2): e4605-e4613, 2022. figures
Artigo em Francês | AIM (África) | ID: biblio-1366667


Contexte et objectif. L'endométriose est une maladie gynécologique caractérisée par la présence des glandes et du stroma endométrial en dehors de la cavité utérine. Elle serait influencée par la nutrition. Cette maladie touche 10 à 15 % des femmes en âge de procréer et a comme composante essentielle l'inflammation chronique. Les symptômes les plus fréquents sont la douleur et l'infertilité. La littérature actuelle fait état des effets bénéfiques des aliments antiinflammatoires et antioxydants sur l'endométriose. L'objectif de la présente mini revue est d'établir des pistes de réflexion sur le bénéfice d'une supplémentation nutritionnelle dans l'endométriose. Méthodes. Nous avons effectué une recherche avec les bases de données de Pubmed, Cinahl, Cochrane Library et Embase pour identifier les articles et essais cliniques randomisés dont sept ont été retenus pour l'analyse. Résultats. La supplémentation en souches probiotiques, en vitamine E et en vitamine C a une influence positive sur les symptômes liés à l'endométriose. De plus, un ensemble des composés contenant des vitamines, sels minéraux, ferments lactiques et oméga 3 et 6 ainsi qu'une alimentation de type anti-inflammatoire et les aliments pauvres en glucides fermentés cibles auraient également une influence positive sur les symptômes. En revanche, la vitamine n'aurait aucun effet significatif. Conclusion. Une prise en charge nutritionnelle, notamment axée sur une supplémentation en antioxydants, anti-inflammatoires et en souches probiotiques constitue une piste prometteuse pour la prise en charge de l'endométriose

Context and objective. Endometriosis is a gynecological disease which is characterized by the presence of endometrial glands and stroma outside the uterine cavity and might be influenced by nutrition. It affects 10 to 15 % of women of childbearing age and has chronic inflammation as an essential component. The most common symptoms are pain and infertility. Current literature reports the beneficial effects of antiinflammatory and antioxidant foods on endometriosis. The present paper reviews the benefits of nutritional supplementation in endometriosis. Methods. A search was performed using the Pubmed, Cinahl, Cochrane Library and Embase database engines to identify articles and randomized clinical trials, of which seven were selected for analysis. Results. Supplementation with probiotic strains, vitamin E and vitamin C has a positive influence on the symptoms associated with endometriosis. In addition, a set of compounds containing vitamins, minerals, lactic ferments and omega 3 and 6 as well as an antiinflammatory type diet and foods low in fermentable carbohydrates would also have a positive influence on the symptoms. In contrast, vitamin D did not have any significant effect. Conclusion. Nutritional management, in particular focusing on supplementation with antioxidants, anti-inflammatory drugs and probiotic strains, is a promising avenue for the management of endometriosis.

Humanos , Feminino , Sinais e Sintomas , Vitamina E , Suplementos Nutricionais , Endometriose , Antioxidantes , Ácido Ascórbico
Artigo em Inglês, Português | LILACS, BDENF - Enfermagem | ID: biblio-1354998


Objetivo: determinar o número de mulheres diagnosticadas com endometriose em consultórios médicos particulares do munícipio de Cruz Alta ­ RS. Método: transversal, prospectivo e descritivo, com cinco médicos ginecologistas que responderam à um questionário sobre as formas de diagnóstico e tratamento da endometriose. Resultados: os resultados demonstraram que a média de mulheres com endometriose foi de quatro pacientes por médico (total de 20 pacientes). A forma de diagnóstico mais utilizada foi a videolaparoscopia, relatada por 80% dos médicos, e as principais formas de tratamento foram por meio dos Análogos do Gonadotrofina (GnRH), como a Gosserrelina e os progestogénos como o Dienogest®. Conclusão: verifica-se que houve um número elevado de mulheres diagnosticadas com endometriose em consultórios particulares no município de Cruz Alta

Objective: to determine the number of patients diagnosed with endometrioses in private medical consultancies in the municipality of Cruz Alta ­ RS. Method: cross-sectional, prospective and descriptive, with five gynecologist doctors who will answer a question about the forms of diagnosis and treatment of endometriose. Results: the results showed that by means of women with endometrium, there were four patients per doctor (total of 20 patients). The most commonly used form of diagnosis was videolaparoscopy, reported by 80% of doctors, and the main forms of treatment were by two Gonadotrophin Analogs (GnRH), such as Gosserrelin and progestogens such as Dienogest®. Conclusion: it was verified that there was a high number of patients diagnosed with endometrioses in private clinics in municipal Cruz Alta

Objetivo: determinar el número de mulheres diagnosticadas con endometriose en consultas médicas particulares del municipio de Cruz Alta ­ RS. Método: transversal, prospectivo y descriptivo, con cinco médicos ginecologistas que responden a un cuestionario sobre formas de diagnóstico y tratamiento de la endometriosis. Resultados: los resultados demostraron que un medio de mulheres com endometriosis de cuarto pacientes por médico (total de 20 pacientes). Una forma de diagnóstico más precisa para una videolaparoscopia, relatada por 80% de dos médicos, y como formas principales de tratamiento de forma por medio de Análogos do Gonadotrofina (GnRH), como Gosserrelina y os progestogénos como o Dienogest®. Conclusión: verifique que tiene un número elevado de multas diagnosticadas con endometrio en consultas particulares no municipales de Cruz Alta

Humanos , Feminino , Adulto , Hormônio Liberador de Gonadotropina , Terapia Combinada , Endometriose , Progestinas
Femina ; 50(3): 178-183, 2022. graf
Artigo em Português | LILACS | ID: biblio-1367572


Objetivo: Analisar o perfil epidemiológico e clínico e a assistência médica fornecida às pacientes acompanhadas no ambulatório específico para endometriose em um hospital universitário público brasileiro. Métodos: Trata-se de um estudo transversal retrospectivo. Foram incluídos os prontuários médicos de 153 pacientes com endometriose acompanhadas em nosso ambulatório desde sua criação, em fevereiro de 2017, até abril de 2020. Os dados coletados foram utilizados para estabelecer os sintomas mais prevalentes, os métodos diagnósticos utilizados, os locais acometidos com maior frequência, o tratamento clínico estabelecido e as características epidemiológicas da população estudada. Resultados: A idade média das pacientes foi de 35,2 ± 7,23 anos. Os sintomas mais prevalentes foram dismenorreia (88,2%), dispareunia (65,4%) e infertilidade (52,9%). O ovário foi o local mais acometido (60,1%). A coexistência de doenças autoimunes foi identificada em 7,2% das pacientes. Cerca de 47,7% das pacientes foram diagnosticadas com ressonância magnética pélvica e 45% foram tratadas com dienogeste. Conclusão: O reconhecimento da epidemiologia da endometriose, os sintomas mais frequentes e as comorbidades associadas à doença podem permitir aos profissionais de saúde melhorar sua capacidade diagnóstica e realizar uma assistência clínica individualizada e eficiente.(AU)

Objective: To analyze the epidemiological and clinical profile and the medical assistance provided to patients followed up in the specific outpatient clinic of endometriosis in a Brazilian public university hospital. Methods: It was a cross-sectional retrospective study. Medical records of 153 patients with endometriosis followed up in our specific outpatient clinic, since its creation, in February 2017, until April 2020 were included. Data collected was used to establish the most prevalent symptoms, diagnostic methods used, most frequent sites of involvement, clinical treatment and epidemiological characteristics of the study population. Results: The mean age of patients was 35.2 ± 7.23 years old. The most prevalent symptoms were dysmenorrhea (88.2%), dyspareunia (65.4%) and infertility (52.9%). Ovary was the most affected site (60.1%). The coexistence of autoimmune disease was identified in 7.2% patients. About 47.7% were diagnosed by pelvic magnetic resonance imaging (MRI) and 45% were treated with dienogest. Conclusion: The recognition of endometriosis epidemiology, the most frequent symptoms and the comorbidities associated with the disease may enable health care professionals to improve the diagnostic capacity and to perform an individualized and efficient clinical assistance.(AU)

Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Adulto Jovem , Endometriose/epidemiologia , Perfil de Saúde , Brasil/epidemiologia , Registros Médicos , Estudos Transversais , Endometriose/diagnóstico , Endometriose/tratamento farmacológico , Hospitais Públicos , Hospitais Universitários