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1.
Materials (Basel) ; 17(13)2024 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-38998277

RESUMO

Continuous fiber-reinforced material extrusion is an emerging additive manufacturing process that builds components layer by layer by extruding a continuous fiber-reinforced thermoplastic strand. This novel manufacturing process combines the benefits of additive manufacturing with the mechanical properties and lightweight potential of composite materials, making it a promising approach for creating high-strength end products. The field of design for additive manufacturing has developed to provide suitable methods and tools for such emerging processes. However, continuous fiber-reinforced material extrusion, as a relatively new technology, has not been extensively explored in this context. Designing components for this process requires considering both restrictive and opportunistic aspects, such as extreme anisotropy and opportunities for functional integration. Existing process models and methods do not adequately address these specific needs. To bridge this gap, a tailored methodology for designing continuous fiber-reinforced material extrusion is proposed, building on established process models. This includes developing process-specific methods and integrating them into the process model, such as a process selection analysis to assess the suitability of the method and a decision model for selecting the process for highly stressed components. Additionally, a detailed design process tailored to continuous fiber-reinforced material extrusion is presented. The application of the developed process model is demonstrated through a case study.

2.
Front Bioeng Biotechnol ; 12: 1384617, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38994126

RESUMO

Introduction: Functional electrical stimulation (FES) is an established method of supporting neurological rehabilitation. However, particularly on the forearm, it still cannot elicit selective muscle activations that form the basis of complex hand movements. Current research approaches in the context of selective muscle activation often attempt to enable targeted stimulation by increasing the number of electrodes and combining them in electrode arrays. In order to determine the best stimulation positions and settings, manual or semi-automated algorithms are used. This approach is limited due to experimental limitations. The supportive use of simulation studies is well-established, but existing simulation models are not suitable for analyses of selective muscle activation due to missing or arbitrarily arranged innervation zones. Methods: This study introduces a new modeling method to design a person-specific digital twin that enables the prediction of muscle activations during FES on the forearm. The designed individual model consists of three parts: an anatomically based 3D volume conductor, a muscle-specific nerve fiber arrangement in various regions of interest (ROIs), and a standard nerve model. All processes were embedded in scripts or macros to enable automated changes to the model and the simulation setup. Results: The experimental evaluation of simulated strength-duration diagrams showed good coincidence. The relative differences of the simulated amplitudes to the mean amplitude of the four experiments were in the same range as the inter-experimental differences, with mean values between 0.005 and 0.045. Based on these results, muscle-specific activation thresholds were determined and integrated into the simulation process. With this modification, simulated force-intensity curves showed good agreement with additionally measured curves. Discussion: The results show that the model is suitable for simulating realistic muscle-specific activations. Since complex hand movements are physiologically composed of individual, selective muscle activations, it can be assumed that the model is also suitable for simulating these movements. Therefore, this study presents a new and very promising approach for developing new applications and products in the context of the rehabilitation of sensorimotor disorders.

3.
J Pharm Bioallied Sci ; 16(Suppl 2): S1345-S1349, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38882775

RESUMO

Andrographis (A.) paniculata contains andrograpanin, which is both anti-inflammatory and anti-infective. Rosa comprises over 150-200 species from the family Rosaceae. Rosa exerts various properties, including anti-inflammatory property. Herbal mouthwash was made using A. paniculata leaf powder and Rosa extract. The anti-inflammatory effect was evaluated using an albumin denaturation assay and egg albumin denaturation. The percentage of protein denaturation that is inhibited by the formulation of A. paniculata and Rosa indicates that it has strong anti-inflammatory effect. According to the findings, as concentration is raised, the formulation's anti-inflammatory activity rises. The formulation's percentage inhibition values are also equivalent to those of a typical anti-inflammatory medicine, indicating that it may be effective as a natural anti-inflammatory agent.

4.
Clin Genitourin Cancer ; 22(4): 102113, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38845330

RESUMO

INTRODUCTION: Food and Drug Administration must make decisions about emerging high intensity focused ultrasound (HIFU) devices that may lack relevant clinical oncologic data but present with known side effects. This study aims to capture patients' perspective by quantifying their preferences regarding the available benefit and important side effects associated with HIFU for localized prostate cancer. MATERIALS AND METHODS: Preferences for HIFU outcomes were examined using a discrete choice experiment survey. Participants were asked to choose a preferred treatment option in 9 choice questions. Each included a pair of hypothetical treatment profiles that have similar attributes/outcomes with varying levels. Outcomes included prostate biopsy outcome and treatment-related risks of erectile dysfunction (ED) and urinary incontinence (UI). We calculated the maximum risk of side effect patients were willing to tolerate in exchange for increased benefit. Preferences were further explored via clinical and demographic data. RESULTS: About 223 subjects with a mean age of 64.8 years completed the survey. Respondents were willing to accept a 1.51%-point increase in new ED risk for a 1%-point increase in favorable biopsy outcome. They were also willing to accept a 0.93%-point increase in new UI risk for a 1%-point increase in biopsy outcome. Subjects who perceived their cancer to be more aggressive had higher risk tolerance for UI. Younger men were willing to tolerate less ED risk than older men. Respondents with greater than college level of education had a lower risk tolerance for ED or UI. CONCLUSIONS: Results may inform development and regulatory evaluation for future HIFU ablation devices by providing supplemental information from the patient perspective.


Assuntos
Preferência do Paciente , Neoplasias da Próstata , Humanos , Masculino , Neoplasias da Próstata/patologia , Neoplasias da Próstata/cirurgia , Pessoa de Meia-Idade , Idoso , Inquéritos e Questionários , Disfunção Erétil/etiologia , Incontinência Urinária/etiologia , Medição de Risco , Ultrassom Focalizado Transretal de Alta Intensidade/métodos , Resultado do Tratamento , Próstata/patologia , Próstata/cirurgia , Ablação por Ultrassom Focalizado de Alta Intensidade/métodos , Ablação por Ultrassom Focalizado de Alta Intensidade/efeitos adversos
5.
Food Res Int ; 190: 114625, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38945579

RESUMO

The cooked ham market is expanding with nitrite-free and meatless alternatives gaining traction as leading trends. An understanding of the attributes that influence the sensory quality of cooked ham is crucial for developing healthier and environmentally sustainable products. The primary aim of this study was to investigate how the removal of nitrites and the use of meatless ingredients affect the sensory characteristics of cooked ham currently available in the Irish market. Sensory evaluation of selected cooked hams (n = 8), including alternatives without nitrites or based on mycoprotein (meatless), was conducted using Temporal Dominance of Sensations (TDS) for in mouth processing and Partial Napping (PN) with Ultra-Flash Profiling (UFP) for the appearance, by a trained sensory panel (n = 9). The nitrite-free cooked ham displayed a similar temporal sensory profile and appearance to the products of the same category, highlighting the opportunity for more nitrite-free products to enter the market. The meatless product was dominated by a "smoky" flavour, which was perceived as "artificial". Meatless ham had a more distinct appearance than the meat-based products and was associated with attributes such as "fake", "artificial colour" and "unappealing". In general, results revealed distinct differences between whole-muscle and sectioned and formed cooked ham products in terms of texture, flavour, and appearance. PN and UFP grouped whole-muscle cooked hams together, which were associated with terms "natural-looking", "better quality" and "healthier", while sectioned and formed cooked hams were perceived as "cheap" and "artificial". The results of this study contribute to a better understanding of the sensory attributes of cooked ham products emphasising the challenges related to novel formulations, and offers valuable insights for the development of healthier and more sustainable meat products within the food industry.


Assuntos
Culinária , Produtos da Carne , Nitritos , Paladar , Humanos , Nitritos/análise , Produtos da Carne/análise , Culinária/métodos , Animais , Adulto , Masculino , Feminino , Suínos , Adulto Jovem , Comportamento do Consumidor , Pessoa de Meia-Idade , Cor
6.
SLAS Discov ; 29(5): 100168, 2024 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-38866329

RESUMO

Despite the efforts towards malaria eradication, latest estimates show that the number of malaria cases is still rising, and malaria continues to have a devastating impact on people's health and livelihoods particularly in populations located in sub-Saharan Africa 1. As a Product Development Partnership (PDP), MMV Medicines for Malaria Venture (MMV) plays a crucial role by using public and philanthropic funds to engage the pharmaceutical industry and academic research institutions to discover, develop and deliver the new drugs needed to control and eradicate malaria. MMV Discovery, working with partners, has developed a robust pipeline of molecules and a reliable discovery engine able to support research projects from screening to candidate nomination, providing access to centers of expertise and evaluating the profile and potential of molecules. To efficiently support this malaria discovery effort, MMV and its partners have established a state-of-the-art compound management network, supporting all discovery activities. This network serves both discovery projects and open innovation initiatives, such as MMV Open, tailoring workflows to align with distinct project objectives. In addition to this, MMV has implemented reliable integrated logistic tools and interfaces. These tools enable the efficient management and tracking of individual not solubilized (dry) samples of project compounds, as well as dedicated, solubilized libraries of compounds designated for primary screens targeting malaria and other neglected diseases.

7.
Health Aff Sch ; 2(1): qxad088, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38770112

RESUMO

Over the past quarter century, product development partnerships (PDPs) have importantly brought health technologies, particularly for neglected diseases, to market for low- and middle-income countries (LMICs). With public sector financing, PDPs de-risk the gulf between where the global burden of disease falls and where paying markets exist. From fighting COVID-19 to developing novel antibiotics, the work of PDPs now extends beyond these traditional bounds. As PDPs have shepherded more health technologies to market, they are also confronting new access challenges. This article lays out 5 areas to strategically leverage the PDP model for better access to new health technologies. Making the case for enhanced support of the PDP approach will require greater transparency, as well as recognition of the contributions made by both public and private sector partners. The governance and funding of PDPs must be accountable to meeting the needs and building capacity of target beneficiaries in LMICs. To take an end-to-end approach, PDPs must work in tandem with other public sector institutions as well as local manufacturers as part of a larger innovation ecosystem. PDPs will need to keep pace with both the dynamics of diseases and markets in delivering the next generation of much needed health technologies.


Product development partnerships (PDPs) play an important role in bringing new and needed health technologies to market, particularly in low- and middle-income countries. As these products emerge from the R&D pipeline, new access challenges in paying for and delivering them in the health care system have emerged. The COVID-19 pandemic has also both stretched and tapped into this work. These developments provide a window of opportunity, both to take stock of lessons learned and of strategic opportunities to leverage the PDP model beyond its traditional bounds of neglected diseases. Greater transparency and recognition of the contributions of PDPs, accountability of governance and surety of financing, and coordination with pooled procurement and local manufacturing initiatives can build a foundation for even more impactful contributions in the future.

8.
Front Reprod Health ; 6: 1272950, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38699591

RESUMO

Product development is a high-risk undertaking, especially so when investments are prioritized for low- and middle-income countries (LMICs) where markets may be smaller, fragile, and resource-constrained. New HIV prevention technologies, such as the dapivirine vaginal ring (DVR) and long-acting injectable cabotegravir (CAB-LA), are being introduced to these markets with one indication, meeting different needs of groups such as adolescent girls and young women (AGYW) and female sex workers (FSWs) in settings with high HIV burden. However, limited supply and demand have made their uptake a challenge. Economic evaluations conducted before Phase III trials can help optimize the potential public health value proposition of products in early-stage research and development (R&D), targeting investments in the development pathway that result in products likely to be available and taken up. Public investors in the HIV prevention pipeline, in particular those focused on innovative presentations such as multipurpose prevention technologies (MPTs), can leverage early economic evaluations to understand the intrinsic uncertainty in market characterization. In this perspective piece, we reflect on the role of economic evaluations in early product development and on methodological considerations that are central to these analyses. We also discuss methods, in quantitative and qualitative research that can be deployed in early economic evaluations to address uncertainty, with examples applied to the development of future technologies for HIV prevention and MPTs.

9.
Data Brief ; 54: 110363, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38590623

RESUMO

The IDEA Challenge 2022 prototyping dataset comprises a total of 240 prototype entries with 1049 edges (connections) and can provide valuable insights into prototyping practices, offering practical knowledge essential for developing prototyping strategies and generating hypotheses for future studies. Data were collected using Pro2booth - an online platform which captured comprehensive information about prototypes and participating teams' development process, including details about the creators, purpose, timing, and methods of creation. It is particularly relevant to design researchers, engineering and design students, educators, and industry professionals seeking to enhance their prototyping skills and strategies. It serves as a robust foundation for subsequent studies, allowing for comparative analyses, hypothesis verification, and trend exploration. It also has the potential to inform meta-analyses across similar design scenarios, providing a comprehensive understanding of prototyping processes.

10.
Soc Stud Sci ; : 3063127241246727, 2024 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-38654559

RESUMO

What is a diagnostic test for? We might assume the answer to this question is straightforward. A good test would help identify what disease someone suffers from, assist health providers to determine the correct course of treatment and/or enable public health authorities to know and intervene in health at the level of the population. In this article, we show that what a specific diagnostic test is for, the value it holds for different actors, and what makes it good, or not, is often far from settled. We tell the story of the development and design of a rapid antibody test for onchocerciasis, or river blindness, tracking multiple iterations of the device through three configurational moments in the framing of onchocerciasis disease and reshaping of the global health innovation ecosystem. Efforts to build that ecosystem for diagnostics are often premised on the notion that public health needs for diagnostics are pre-given and stable; the challenge is seen to be how to incentivize investment and find a customer base for diagnostics in under-resourced settings. By contrast, we show that for any disease, diagnostic needs are both multiple and constantly in flux, and are unlikely to be met by a single, stand-alone product. In the case of the onchocerciasis Ov-16 rapid test, the failure to recognize and address the multiplicity and instability of diagnostic needs in the innovation process resulted in the development of a rapid point of care test that might be manufactured, procured and used, but is unloved by public health experts and commercial manufacturers alike. The equivocal value of the onchocerciasis rapid test, we suggest, reveals the inadequacy of the current global health innovation ecosystem for developing diagnostic 'goods'.

11.
Cureus ; 16(3): e55472, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38571817

RESUMO

Background In this research, iron oxide nanoparticles were synthesized using Coleus amboinicus stem extract, which is used for various diseases such as throat infection, cough, fever, nasal congestion, and digestive problems.  Aim This study aimed to formulate a green synthesis of iron oxide nanoparticles mediated by Coleus amboinicus (known as karpuravalli in Tamil) and assess its antimicrobial and antioxidant properties.  Materials and methods Iron oxide nanoparticles were synthesized, and then their antimicrobial properties were tested against two specific pathogens, i.e., Streptococcus mutans and Candida albicans, using the agar well diffusion technique. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, hydroxyl radical scavenging (H2O2) assay, and ferric ion reducing antioxidant power (FRAP) assay were conducted to check the free radical scavenging activity.  Result The results obtained showed that these iron oxide nanoparticles showed better antimicrobial activity against Streptococcus mutans when compared to Candida albicans, and the antioxidant activity showed a very close efficacy when compared to the standard.  Conclusion The research has demonstrated the high antioxidant activity and high antibacterial activity of iron oxide nanoparticles using Coleus amboinicus stem, a natural and cheaper antimicrobial drug compared to the drugs present on the market.

12.
Cureus ; 16(2): e53671, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38455834

RESUMO

Introduction Nanotechnology holds considerable importance in biomedical and dental applications. Nanoparticles synthesized using green synthesis methods with herbal formulations offer various benefits to humans. Zinc oxide nanoparticles (ZnONPs), being semiconductors, exhibit potent antibacterial properties. Notably, treatments utilizing lemongrass and mint ensure potentially lower toxicity and antibacterial qualities for oral infections. The goal of the study is to prepare a mouthwash mediated by ZnONPs and assess its cytotoxic potential and antibacterial efficacy. Materials and methods A lemongrass and mint formulation was used in the synthesis of ZnONPs, and the mouthwash was prepared using the synthesized nanoparticles. The produced ZnONPs were tested for their antimicrobial activity using agar well diffusion technique against oral pathogens, and the ZnONPs-mediated mouthwash was evaluated for its cytotoxic effect using the brine shrimp lethality assay and compared to commercial mouthwash.  Results The green-synthesized ZnONPs were initially confirmed using a UV-visible spectrophotometer and exhibited a maximum peak at 362 nm. The antimicrobial activity was tested for the synthesized ZnONPs against oral pathogens, which showed a maximum zone of inhibition of 22 mm in Enterococcus faecalis and 23 mm in Candida albicans, as estimated by the agar well diffusion technique. Additionally, ZnONPs-based herbal mouthwash demonstrated lower cytotoxicity than the commercial mouthwash in the brine shrimp lethality assay. Conclusion In the current study, lemongrass and mint-mediated ZnONPs demonstrated an effective antibacterial activity against E. faecalis and antifungal activity against C. albicans. Furthermore, the cytotoxic effect tested using the brine shrimp lethality assay for ZnONPs-mediated mouthwash demonstrated lower toxicity as compared to the commercial mouthwash. This suggests that the green-synthesized ZnONPs-based mouthwash could be used as an alternative to synthetic mouthwash.

13.
Trop Med Infect Dis ; 9(3)2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38535880

RESUMO

Medicine development is a lengthy endeavour. Increasing regulatory stringency and trial complexity might lead to reduced efficiency, dwindled output, and elevated costs. However, alternative models are possible. We compared the operational differences between pharmaceutical industry sponsored trials, product development partnership trials, and investigator-initiated trials to identify key drivers of inefficiency in clinical research. We conducted an exploratory mixed-methods study with stakeholders, including clinical trial sponsors, contract research organisations, and investigators. The qualitative component included 40 semi-structured interviews, document reviews of 12 studies and observations through work shadowing in research institutions in Burkina Faso, Mali, and Switzerland. The findings were triangulated with an online survey polling clinical research professionals. The operational differences were grouped under five categories: (i) trial start-up differences including governance and management structure; (ii) study complexity; (iii) site structural and organisational differences; (iv) study conduct, quality approaches, and standard operating procedures; and (v) site capacity strengthening and collaboration. Early involvement of sites in the planning and tailored quality approaches were considered critical for clinical operations performance. Differences between the types of trials reviewed pertained to planning, operational complexities, quality approaches, and support to the sites. Integration of quality-by-design components has the potential to alleviate unnecessary process burden.

14.
Curr Alzheimer Res ; 2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38425107

RESUMO

OBJECTIVE: Alzheimer's disease, a progressive neurodegenerative disorder, severely impacts cognitive function and daily living. The current treatment provides only symptomatic relief, and thus, disease-modifying therapies targeting underlying causes are needed. Although several potential therapies are in various stages of clinical trials, bringing a new Alzheimer's drug to market remains challenging. Hence, researchers are also exploring monoclonal antibodies, tau protein inhibitors, and anti-inflammatory drugs as treatment options. Conventionally designed dosage forms come with limitations like poor absorption, first-pass metabolism, and low bioavailability. They also cause systemic adverse effects because these designed systems do not provide target- specific drug delivery. Thus, in this review, the authors highlighted the current advancements in the development of intranasal nanoformulations for the treatment of Alzheimer's disease. This strategy of delivering anti-Alzheimer drugs through the nasal route may help to target the drug exactly to the brain, achieve rapid onset of action, avoid first-pass metabolism, and reduce the side effects and dose required for administration. CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.

15.
Cureus ; 16(2): e53489, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38440044

RESUMO

Aim This study aimed to compare the antidiabetic effect of metal oxide nanoparticles (CuONPs and ZnONPs) prepared using lemongrass and mint herbal formulations. Introduction The study explores green-synthesized nanoparticles for potential applications in diabetes management, emphasizing sustainable synthesis methods, particularly zinc oxide nanoparticles (ZnONPs) and copper oxide nanoparticles (CuONPs) produced from lemongrass and mint herbal formulations. The study was prompted by the increasing importance of innovative therapeutic strategies, responding to emerging health challenges, and leveraging advancements in nanotechnology and eco-friendly practices to explore the potential of green-synthesized nanoparticles in diabetes management. Methods The methods involve herbal formulation preparation, CuONPs and ZnONPs synthesis, and UV-visible spectrophotometry for characterization. In vitro antidiabetic activity is assessed through α-amylase and ß-glucosidase enzyme assays using varied nanoparticle concentrations (10-50 µL). Results Visual observations confirm successful synthesis, with distinct color changes observed in both CuONPs and ZnONPs after 24 hours. UV-visible spectrophotometry reveals absorption peaks at 440 nm and 380 nm for CuONPs and ZnONPs, respectively. In the α-amylase assay, both nanoparticles exhibit concentration-dependent inhibition, with CuONPs ranging from 40% to 77% and ZnONPs ranging from 36% to 80%. The ß-glucosidase assay demonstrates similar concentration-dependent inhibition patterns, highlighting significant differences. Conclusion The study concludes that CuONPs and ZnONPs synthesis using lemongrass and mint herbal formulations show concentration-dependent antidiabetic activity. The comparative analysis underscores the need for tailored approaches based on nanoparticle composition. These findings contribute valuable insights into the therapeutic potential of green-synthesized nanoparticles, paving the way for future nanomedicine research and development in diabetes management.

16.
Heliyon ; 10(5): e27005, 2024 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-38495165

RESUMO

This paper explores the application of Set-based Design (SBD) in the design of a dates harvesting machine. Dates are a popular fruit with significant economic importance, especially in Saudi Arabia. However, the process of harvesting them is highly labour-intensive, and there is a need for an automated solution to improve efficiency and reduce costs. The study begins with a comprehensive review of the literature on other fruit-harvesting machines. The research then proposes an architectural design of a dates harvesting machine based on the understanding of the typical fruit harvesting machines. The dates harvesting machine design proposed in this study consists of several sub-assemblies. Each sub-assembly is designed as a set of alternatives, with different configurations of components, mechanisms and materials. The understanding of the customer requirements of typical date farms helped to identify the list of values that are essential to design the dates harvesting machine. These values were filtered and analysed using an analytical hierarchy process to define three key value attributes of 'design performance', 'safety' and 'cost'. The SBD approach helped to evaluate all the possible combinations of subsystems to identify the optimal solution that meets the customer's requirements and constraints. The SBD methodology resulted in the generation of 576 alternative design configurations which were aggressively narrowed down to 48 design solutions and then into 4 solutions where the final optimized design was selected using the PUGH matrix. The narrowing down is based on the combination of trade-off curves, solution performance and the identified key-value attributes. The proposed dates harvesting machine design shows great promise in improving the efficiency and sustainability of harvesting dates, and it can be adapted for use in agricultural applications.

17.
Arch. latinoam. nutr ; 74(1): 10-21, mar. 2024. ilus, tab
Artigo em Espanhol | LILACS, LIVECS | ID: biblio-1555081

RESUMO

Introducción: Las ciencias de la nutrición y los alimentos innovan en la industria elaborando productos con compuestos nutricionales que contribuyan a la resolución de problemáticas en salud pública. Pero, además de las características nutricionales, son importantes las características sensoriales, siendo un factor determinante en la aceptación de estos productos. Objetivo: Evaluar características fisicoquímicas, nutricionales y sensoriales de dos complementos alimenticios, tipo sopa y bebida achocolatada, desarrollados con biofortificación. Materiales y métodos: Se consideraron 3 fases, fase 1, preparación de dos tipos complementos alimenticios (4 formulaciones), usando la liofilización para la deshidratación de algunas materias primas, complementada con otras técnicas de procesamiento y cocción. Fase 2, evaluación sensorial por panel de expertos a través de prueba descriptiva cuantitativa y hedónica, y fase 3, caracterización bromatológica. El análisis de la información se realizó con el software Jamovi 2.3.21. mediante análisis descriptivo e inferencial. Resultados: El análisis sensorial evidenció que los alimentos que contiene corazón de res en un 5% fueron los más aceptados por los panelistas en todos los atributos sensoriales en ambos complementos. La caracterización bromatológica mostró que el complemento tipo bebida achocolatada con corazón es excelente fuente de proteína, zinc y calcio y buena fuente de hierro y vitamina E, mientras que, el complemento tipo sopa con corazón es excelente fuente de proteína, zinc, hierro, tiamina, omega 3, vitamina E y buena fuente de calcio de acuerdo con la normatividad colombiana de rotulado y etiquetado nutricional. Conclusiones: Ambos complementos con corazón mostraron una aceptación sensorial satisfactoria, presentaron una importante concentración de nutrientes, que, por su fuente natural y animal, son considerados de alta biodisponibilidad(AU)


Introduction: Nutrition and food sciences innovate in the industry by elaborating products with nutritional compounds that contribute to the resolution of public health problems. But, in addition to nutritional characteristics, sensory characteristics are important, being a determining factor in the acceptance of these products. Objective: To evaluate physicochemical, nutritional and sensory characteristics of two food supplements, soup and chocolate drink, developed with biofortification. Materials and methods: Three phases were considered: phase 1, preparation of two types of food supplements (4 formulations), using freeze-drying for dehydration of some raw materials, complemented with other processing and cooking techniques. Phase 2, sensory evaluation by expert panel through quantitative descriptive and hedonic test, and phase 3, bromatological characterization. The analysis of the information was carried out with Jamovi 2.3.21. software through descriptive and inferential analysis. Results: The sensory analysis showed that foods containing 5% beef heart were the most accepted by the panelists in all sensory attributes in both supplements. The bromatological characterization showed that the chocolate drink type supplement with heart is an excellent source of protein, zinc and calcium and a good source of iron and vitamin E, while the soup type supplement with heart is an excellent source of protein, zinc, iron, thiamine, omega 3, vitamin E and a good source of calcium in accordance with Colombian regulations on nutritional labeling and labeling. Conclusions: Both supplements with heart showed a satisfactory sensory acceptance, presented an important concentration of nutrients, which, due to their natural and animal source, are considered of high bioavailability(AU)


Assuntos
Alimentos Formulados , Suplementos Nutricionais
18.
Vaccine ; 42(6): 1230-1246, 2024 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-38326130

RESUMO

As an innovative vaccine delivery technology, vaccine microarray patches could have a meaningful impact on routine immunization coverage in low- and middle-income countries, and vaccine deployment during epidemics and pandemics. This review of the potential use cases for a subset of vaccine microarray patches in various stages of clinical development, including measles-rubella, measles-mumps-rubella, and typhoid conjugate, highlights the breadth of their applicability to support immunization service delivery and their potential scope of utilization within national immunization programs. Definition and assessment of the use cases for this novel vaccine presentation provide important insights for vaccine developers and policymakers into the strengths of the public health and commercial value propositions, and the preparatory requirements for public health systems for the future rollout of vaccine microarray patches. An in-depth understanding of use cases for vaccine microarray patches serves as a foundational input to overcoming the remaining technical, regulatory, and financial challenges. Additional efforts will help to realize the potential of vaccine microarray patches as part of the global effort to improve the coverage and equity of national immunization programs.


Assuntos
Sarampo , Caxumba , Rubéola (Sarampo Alemão) , Febre Tifoide , Vacinas Tíficas-Paratíficas , Humanos , Lactente , Caxumba/prevenção & controle , Vacinas Conjugadas , Febre Tifoide/prevenção & controle , Rubéola (Sarampo Alemão)/prevenção & controle , Sarampo/prevenção & controle , Vacina contra Rubéola , Vacina contra Caxumba , Vacinação , Vacina contra Sarampo-Caxumba-Rubéola
19.
Compr Rev Food Sci Food Saf ; 23(1): e13247, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-38284589

RESUMO

Low consumer acceptance of edible insects and insect-based products is one of the main barriers to the successful implementation of entomophagy in Western countries. This rejection is mainly caused by consumers' negative emotional responses, psychological/personality traits, and attitudes toward food choices. However, as the role of intrinsic product characteristics on such food choices has not been adequately studied, a systematic review was conducted following the PRISMA method, to analyze studies that have assessed hedonic evaluations, sensory profiling, or emotional responses to edible insects or insect-based products. The majority of studies performed with whole insects and insect flour highlight that insect-based products are more negatively evaluated than control products. Although the sensory properties of insects are affected by species and processing conditions, they are generally negative across sensory dimensions. In particular, insects and insect-based products are generally associated with odor and flavor/taste attributes that are related to old/spoiled food. These negative attributes can be linked to the fat fraction of edible insects, with insect oils being very negatively evaluated by consumers. On the other hand, defatted fractions and deodorized oils are not associated with these negative attributes, further supporting the hypothesis that the fat fraction is responsible for the negative odor and flavor/taste attributes. However, there is still a lack of studies assessing the sensory profile of edible insects and insect-based products, as well as consumers' emotional responses to their consumption. Future studies should focus on the effects of different processing conditions, products incorporating insect fractions (namely protein concentrates/isolates and defatted fractions), and evaluation by target consumer groups.


Assuntos
Insetos Comestíveis , Animais , Emoções , Farinha , Insetos , Óleos , Humanos
20.
Materials (Basel) ; 17(2)2024 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-38255591

RESUMO

This work aims to obtain recycled carbon fibre and develop an application for this new material. The carbon fibres were obtained by recycling aerospace prepreg waste via the pyrolysis process. The recycled fibres were combined with an Araldite LH5052/Aradur LY5053 epoxy resin/hardener system using manual lay-up and vacuum bagging processes. For comparison, the same resin/hardener system was used to produce a composite using commercial carbon fibre. The recycled and commercial composites were subjected to flexural, tensile and Mode I testing. Fracture aspects were analysed via scanning electron microscopy (SEM). The pyrolysis process did not affect the fibre surface as no degradation was observed. The fracture aspect showed a mixture of failure in the recycled composite laminate and interlaminar/translaminar failure near the surface of the commercial composite caused by flexural stress. Flexural and tensile tests showed a loss of mechanical strength due to the recycling process, but the tensile values were twice as high. The sand ladder platform was the project chosen for the development of a product made with recycled carbon fibres. The product was manufactured using the same manufacturing process as the specimens and tested with a 1243 kg car. The method chosen to design, manufacture and test the prototype sand ladder platform made of recycled carbon fibre was appropriate and gave satisfactory results in terms of high mechanical strength to bending and ease of use.

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