RESUMO
The indications for nystatin as prophylaxis or treatment are limited. In the PASOAP (Pediatric Antifungal Stewardship Optimizing Antifungal Prescription) study, high use of nystatin in hospitalized children beyond the neonatal age was observed. In this report, we present the data on nystatin use in infants and children ≥ 3 months who participated in the PASOAP study. Nystatin was prescribed mainly for prophylaxis. Congenital heart disease, cystic fibrosis, and chronic renal disease were the most commonly reported conditions in children receiving prophylactic nystatin. There is sparse evidence supporting the use of nystatin prophylaxis beyond neonates; trials in specific pediatric patient groups are required.
The topical antifungal nystatin has not many indications. Prophylaxis of invasive candidiasis in very low birth weight neonates is one of them. In our study, we found that nystatin prophylaxis was used frequently beyond this specific neonatal group. Stronger evidence justifying its use is required.
Assuntos
Fibrose Cística , Doenças do Prematuro , Animais , Humanos , Recém-Nascido , Nistatina/uso terapêutico , Antifúngicos/uso terapêutico , Doenças do Prematuro/tratamento farmacológico , Doenças do Prematuro/veterinária , Recém-Nascido de muito Baixo Peso , Fibrose Cística/tratamento farmacológico , Fibrose Cística/veterináriaRESUMO
El síndrome de maladaptación del neonato afecta a potros en su primera semana de vida (generalmente en las primeras 24 horas) y se manifiesta con alteraciones importantes del comportamiento de causa no infecciosa. Este síndrome también incluye los déficits neurológicos que presentan los potros prematuros, que se asocian con hipoactividad adrenocortical. Resultan escasos los trabajos publicados sobre hipoactividad adrenocortical en la especie equina, en concreto en potros, en relación con el síndrome de maladaptación. Este trabajo describe los hallazgos clínicos y laboratoriales en una potra con pocas horas de vida, las técnicas diagnósticas seguidas así como el tratamiento empleado, que dio lugar a la curación del animal. (AU)
Assuntos
Animais , Doenças do Prematuro/veterinária , Adaptação Biológica/fisiologia , Doenças dos Cavalos/prevenção & controle , Doenças dos Cavalos/fisiopatologia , Cavalos/fisiologia , Corticosteroides/administração & dosagem , Corticosteroides/uso terapêutico , Hidratação/veterinária , Oxigênio/uso terapêutico , Alimentação com Mamadeira/veterinária , Antibacterianos/uso terapêuticoRESUMO
The authors used the premature rabbit model to examine the pathophysiology of intraventricular hemorrhage (IVH). They studied the brains of 167 control animals, of 45 animals after a hypertensive insult, of three animals after a bolus infusion of normal saline, and of 10 animals after both insults. In none of the brains was IVH identified. Limited reproducibility may restrict the use of this animal model.