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1.
Int J Hyperthermia ; 35(1): 37-43, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29807444

RESUMO

PURPOSE: We used an impedance-controlled generator with an internally cooled electrode to perform radiofrequency ablation (RFA) in ex vivo bovine livers, with a single injection of either 38.5% sodium chloride (NaCl) or 10% hydrochloric acid (HCl), to determine the relative effects of these two solutions on tissue impedance, temperature and ablation volume. MATERIALS AND METHODS: We performed 10 ablations each with injections of NaCl (NaCl-RFA), HCl (HCl-RFA) or nothing (RFA-alone), with a power setting of 200 W for 15 minutes. We recorded tissue impedance before and after injection. We logged temperatures obtained from thermocouple probes positioned 5, 10, 15 and 20 mm from the internally cooled RF electrode. After ablation, we measured ablation zone longitudinal and transverse diameters, and we calculated a spherical ratio (SR) for each ablation. RESULTS: Mean post-injection impedance of 30.3 (standard deviation [SD] 2.5) ohms for HCl was significantly lower than that of 55.4 (SD 3.5) ohms for NaCl (p < .001). Mean maximum temperatures recorded at each respective distance from the RFA electrode were all highest for HCl-RFA and lowest for RFA-alone (p < .001). Mean longitudinal and transverse diameters after HCl-RFA (5.50 [SD 0.25] cm and 5.28 [SD 0.22] cm, respectively) were significantly larger than those after NaCl-RFA (4.24 [SD 0.35] cm and 3.55 [SD 0.43] cm, respectively) and after RFA-alone (3.60 [SD 0.10] cm and 2.70 [SD 0.13] cm, respectively) (p < .001). Mean SR after HCl-RFA (0.93, SD 0.02) was significantly higher than mean SR after NaCl-RFA (0.76, SD 0.06) and RFA-alone (0.72, SD 0.04) (p < .001). CONCLUSION: Monopolar, impedance-controlled RFA, with an internally cooled electrode and a single 10% HCl injection may allow larger tumors to be treated, potentially resulting in improved patient outcomes.


Assuntos
Ácido Clorídrico/uso terapêutico , Fígado/cirurgia , Ablação por Radiofrequência/métodos , Animais , Bovinos , Temperatura Baixa , Eletrodos , Ácido Clorídrico/farmacologia , Modelos Animais
2.
Int J Hyperthermia ; 34(7): 925-933, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-29457524

RESUMO

PURPOSE: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissues, prospectively using in vivo rabbit and ex vivo porcine liver models. MATERIALS AND METHODS: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103 °C and 30 W for 3 min. For each experimental setting, six ablations were created. Safety was assessed by comparing baseline weight and selected laboratory values with those at 2, 7, and 14 days' post-ablation, and by histopathological analysis. The livers in 25 pigs were treated ex vivo with the same five perfusions during RFA at 103 °C, at both 30 W and 60 W, for 30 min. Ablation diameters and volumes were measured by two examiners. RESULTS: Rabbit weights and selected laboratory values did not differ significantly from baseline to 7 and 14 days' post-ablation, liver tissues outside the ablation zones were normal histologically, and adjacent organs showed no macroscopic damage. The mean ablation volumes in the porcine livers treated with HCl-RFA were all larger than those treated with normal saline perfusion during RFA (NS-RFA), at both 30 W and 60 W (p < 0.001). The largest ablation volume and transverse diameter were observed in the porcine livers during 10% HCl-RFA at 60 W, measuring 179.22 (SD = 24.79) cm3 and 6.84 (SD = 0.36) cm, respectively. CONCLUSIONS: Based on our experiments, HCl-RFA in the liver appears to be as safe as NS-RFA while also resulting in larger ablation zones.


Assuntos
Ácido Clorídrico/uso terapêutico , Ablação por Radiofrequência/métodos , Animais , Modelos Animais de Doenças , Ácido Clorídrico/farmacologia , Fígado/cirurgia , Perfusão , Coelhos , Suínos
3.
Chin J Cancer ; 36(1): 1, 2017 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-28061892

RESUMO

BACKGROUND: A ruptured hepatocellular carcinoma (HCC) is often fatal. In addition to surgery and transarterial embolization, radiofrequency ablation (RFA) might be another option for treating a ruptured HCC. Unfortunately, conventional RFA has a limited ablation zone; as such, it is rarely used to treat ruptured tumors. CASE PRESENTATION: This case was a 60-year-old man who had a large, ruptured HCC in which hydrochloric acid (HCl)-enhanced RFA successfully controlled the bleeding and made the tumor completely necrotic. CONCLUSION: Considering the effectiveness of HCl-enhanced RFA in achieving hemostasis and tumor ablation, it might be a new option for treating large, ruptured HCCs.


Assuntos
Carcinoma Hepatocelular/terapia , Ablação por Cateter/métodos , Ácido Clorídrico/administração & dosagem , Neoplasias Hepáticas/terapia , Carcinoma Hepatocelular/diagnóstico por imagem , Humanos , Ácido Clorídrico/uso terapêutico , Neoplasias Hepáticas/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Ruptura Espontânea/terapia , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
4.
Appl Immunohistochem Mol Morphol ; 25(2): 144-149, 2017 02.
Artigo em Inglês | MEDLINE | ID: mdl-27028239

RESUMO

CONTEXT: In the United States, it is estimated that 100,000 people are living with metastatic breast cancer (BC) with bone representing the most common site of involvement. However, patients with isolated bone metastasis at presentation may have a longer survival. Therapeutic options for BC bone metastases often include systemic anticancer therapy (endocrine, chemotherapy, monoclonal antibodies, and/or other targeted therapies), which is largely dependent on the immunohistochemical (IHC) repertoire of the cancer for the prognostic markers [estrogen (ER) and progesterone receptors (PR), Ki-67, p53, and Her-2/neu] at its osseous metastatic site. Traditionally, specimens obtained from the bone metastasis require decalcification, which may affect the immunoreactivity of these prognostic markers. To the best of our knowledge, limited studies describe the effect of decalcification on immunoexpression of the above-mentioned markers. A detailed illustration of the effect of decalcification on BC specimens in a real-time manner is lacking in the literature. OBJECTIVE: Herein, we sought to determine the impact of decalcification on the IHC expression pattern of the above listed markers on BC tissue following decalcification. DESIGN: After Institutional Review Board approval, sections from the residual tumor specimens were collected prospectively from 15 BC excision specimens and 1 curetting from a BC bone metastasis. The sections (3 to 6 sections/case) for decalcification were collected following routine submission for pathologic evaluation. The sections were subjected to hydrochloric acid (HCl)-based Decal Stat decalcifying solution for 2, 12, 18, and 24 hours in each case. IHC studies for ER, PR, Ki-67, p53, and Her-2/neu were performed on 1 representative section of the regularly processed tumor block and 1 decalcified tumor block from each time point. Scoring of ER and PR were performed according to the Allred scoring system. Scoring of Her-2/neu was performed according to CAP/ASCO guidelines. RESULTS: The tumors comprised 11 grade 3 invasive ductal carcinomas, 2 grade 2 invasive ductal carcinomas, 2 grade 3 invasive lobular carcinoma, and 1 metastatic BC to bone. Nine cases showed Allred score 8 for ER, 1 case showed Allred score 4, 1 case showed Allred score 2, and the remaining 5 were ER negative. For PR, 1 showed Allred score 8, 2 Allred score 7, 4 Allred score 6, 1 each Allred score 5 and score 2 with the remainder negative for PR. Ki-67 ranged from 5% to 95%. Five cases showed p53 overexpression ranging from 35% to 95%. Five cases each showed 3+, 6 cases showed 2+ Her-2/neu, 3 cases showed 1+ Her-2/neu, and the remaining 2 were negative. All specimens demonstrated decline in ER, PR, Ki-67, and p53 immunoreactivity after 2 hours of decalcification, with additional decline up to 24 hours. The most significant declines in immunoreactivity occurred with Ki-67 and p53. Most of the Her-2/neu cases with an equivocal score declined to zero after 24 hours of decalcification. However, 3 out of 11 cases showing Her-2/neu overexpression remained at the baseline scoring even after extended (24 h) decalcification. CONCLUSIONS: Our results demonstrated that the decalcification process affects the immunoreactivity of the prognostic BC markers. There is progressive loss of reactivity at 2 hours and beyond for markers with lower degrees of expression. In addition, heterogeneity in marker distribution progressed from diffuse to more focal beyond 1 hour.


Assuntos
Neoplasias Ósseas/secundário , Neoplasias da Mama/patologia , Calcinose/tratamento farmacológico , Ácido Clorídrico/uso terapêutico , Adulto , Idoso , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto Jovem
5.
Head Face Med ; 11: 32, 2015 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-26407628

RESUMO

BACKGROUND: The aim of this study was to investigate the influence of etching time with 15% hydrochloric acid (HCl) on the enamel surface destruction by studying the resulting roughness and erosion depth. METHODS: The vestibular surfaces of 12 extracted, caries free human incisors were divided into four quadrants, and each quadrant was etched with 15% HCl for different numbers of etching cycles (1×2, 2×2, 3×2 and 4×2 min). Surface roughness and erosion depth were measured quantitatively with optical profilometry, and the surface morphology was imaged with scanning electron microscopy (SEM). RESULTS: After two minutes of 15% HCl application a median enamel substance loss of 34.02 µm was observed. Lengthening of etching time (2×2, 3×2 and 4×2 min) resulted in significantly increase in erosion depth to each additionally, between 13.28 -15.16 µm (p < 0.05) ending up in a total median enamel surface loss of 77 µm. Regarding surface roughness no significant (p > 0.05) difference was found between unetched enamel and the etched enamel surfaces. CONCLUSION: Repeated 15% HCl conditioning of the enamel surface increases the depth of the etched surface erosion. However, the total erosion depth is rather shallow and therefore negligible.


Assuntos
Condicionamento Ácido do Dente/efeitos adversos , Esmalte Dentário/efeitos dos fármacos , Ácido Clorídrico/efeitos adversos , Condicionamento Ácido do Dente/métodos , Humanos , Ácido Clorídrico/uso terapêutico , Incisivo , Microscopia Eletrônica de Varredura , Propriedades de Superfície
6.
Antimicrob Agents Chemother ; 59(11): 6968-74, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26324263

RESUMO

Mucormycosis is a fatal fungal disease caused by several organisms within the order Mucorales. In recent years, traumatic injury has emerged as a novel risk factor for mucormycosis. Current antifungal therapy is ineffective, expensive, and typically requires extensive surgical debridement. There is thus a pressing need for safe prophylactic treatment that can be rapidly and easily applied to high-risk patients, such as those with major trauma injuries. Acetic acid has been used as a topical treatment for burn wounds for centuries and has proven activity against Gram-negative bacteria. Here, we demonstrate that acetic acid is also highly effective against major pathogenic groups of Mucorales, even at very low concentrations (0.3%). This antifungal effect is not seen with other acids, such as hydrochloric and lactic acid, suggesting that acetic acid activity against Mucorales spores is not solely evoked by low environmental pH. In agreement with this, we demonstrate that the antifungal activity of acetic acid arises from a combination of its ability to potently lower intracellular pH and from pH-independent toxicity. Thus, dilute acetic acid may offer a low-cost, safe, prophylactic treatment for patients at risk of invasive mucormycosis following traumatic injury.


Assuntos
Mucormicose/tratamento farmacológico , Antifúngicos/uso terapêutico , Humanos , Ácido Clorídrico/uso terapêutico , Concentração de Íons de Hidrogênio , Ácido Láctico/uso terapêutico , Mucorales/efeitos dos fármacos , Mucorales/patogenicidade
7.
J Clin Pediatr Dent ; 38(3): 207-13, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25095314

RESUMO

OBJECTIVE: The present study was conducted to compare and evaluate the relative efficacy of enamel microabrasion (using 18% HCl) and bleaching with McInnes solution in the esthetic improvement of fluorosed teeth and to check postoperative sensitivity. STUDY DESIGN: 30 children aged between 9-14yrs with a mild or moderate grade of fluorosis as classified according to Dean's fluorosis index and who complained of objectionable esthetics were selected. Split mouth study design was selected in our study. Each subject had one of their maxillary central incisor randomly selected for Enamel microabrasion and the contra lateral maxillary central incisor for McInnes bleaching. Esthetic improvement was assessed by comparing the pre and postoperative digital photographs. During the evaluation session, the pre and postoperative photographs of 30 subjects were incorporated into a power point presentation and were projected side by side in a darkened room. Four calibrated and blinded examiners, including a layman rated the photographs under standardized viewing conditions. Esthetic improvement was assessed for both short and long term improvement. The postoperative sensitivity was recorded for both the procedures immediately after treatment and at one, three and six months interval. RESULTS: The results proved that both immediate and long term (6 month) esthetic improvement achieved by McInnes bleaching were superior to enamel microabrasion. There is a reduction in aesthetics of teeth in both the procedures after six months, which was very minimal in McInnes procedure and significant in enamel micro abrasion. Postoperative sensitivity in both techniques were negligible. The sensitivity observed were transient and subsided within an one-month post operatively. None of the subjects reported sensitivity at one, three and six months intervals. CONCLUSION: McInnes bleaching is a better procedure compared to enamel microabrasion in improving the appearance of fluorosed teeth. Both techniques are conservative and safe.


Assuntos
Abrasão Dental por Ar/métodos , Esmalte Dentário/patologia , Fluorose Dentária/terapia , Clareamento Dental/métodos , Descoloração de Dente/terapia , Adolescente , Abrasão Dental por Ar/instrumentação , Criança , Esmalte Dentário/efeitos dos fármacos , Sensibilidade da Dentina/etiologia , Estética Dentária , Seguimentos , Humanos , Ácido Clorídrico/uso terapêutico , Peróxido de Hidrogênio/uso terapêutico , Fotografia Dentária/métodos , Silicatos/uso terapêutico , Clareadores Dentários/uso terapêutico , Resultado do Tratamento
8.
J Clin Pediatr Dent ; 39(1): 27-9, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25631722

RESUMO

The aim of the present study was to describe a clinical protocol for the treatment of white spots with the use of an abrasive material. A four-year-old patient presented with a white spot on tooth 51 and a white spot associated with a carious lesion in the cervical region of tooth 52. Treatment was planned with microabrasion and restoration of the upper right lateral incisor. Prophylaxis was first performed, followed by protection with a dental dam and the application of the abrasive material (silicon carbide and hydrochloric acid 6%). Five applications were needed to remove the spots. The restoration of the upper right lateral incisor was then performed with a resin composite. A good esthetic outcome was achieved and both the patient and her guardians were satisfied with the results. Microabrasion is a conservative treatment option that achieves satisfactory results with regard to tooth color.


Assuntos
Cárie Dentária/terapia , Microabrasão do Esmalte/métodos , Compostos Inorgânicos de Carbono/uso terapêutico , Pré-Escolar , Protocolos Clínicos , Resinas Compostas/química , Materiais Dentários/química , Profilaxia Dentária , Restauração Dentária Permanente/instrumentação , Restauração Dentária Permanente/métodos , Estética Dentária , Humanos , Ácido Clorídrico/uso terapêutico , Incisivo/patologia , Masculino , Diques de Borracha , Compostos de Silício/uso terapêutico , Colo do Dente/patologia
9.
Arq. odontol ; 50(03): 142-148, 2014. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-850180

RESUMO

Objetivo: O objetivo desse artigo é relatar um caso clínico apresentando a técnica de microabrasão de esmalte como opção eficaz de tratamento de fluorose dentária moderada. Relato de caso: O paciente de 12 anos de idade, sexo masculino, exibia graus TF=5 nos incisivos superiores e TF=4 nos demais dentes. O tratamento consistiu de três sessões, com intervalo de 1 semana, de aplicação da pasta microabrasiva contendo ácido clorídrico 6% e carbeto de silício como meio abrasivo, seguido da aplicação de fluoreto de sódio neutro 1,23%. Os resultados estéticos foram clinicamente satisfatórios com notável clareamento das superfícies dentáriasafetadas e remoção do esmalte fluorótico com perda de estrutura focal. Além disso, como a queixa principaldo paciente foi a insatisfação com a aparência dos seus dentes e as consequências causadas por esse fator, ao término do tratamento o paciente demonstrou muita satisfação com o resultado obtido. Conclusão: A técnicade microabrasão favorece a estética do sorriso e contribui para a melhora da auto-estima e o convívio social.


Assuntos
Humanos , Masculino , Feminino , Fluorose Dentária/terapia , Microabrasão do Esmalte , Ácido Clorídrico/uso terapêutico , Esmalte Dentário/lesões
12.
J Surg Res ; 184(2): 1143-9, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23706563

RESUMO

BACKGROUND: We tested whether an injured lung graft from category-3 donation after cardiac death donor could be reconditioned with an ex vivo lung perfusion (EVLP) system by intrabronchial diluted surfactant lavage before transplantation. METHODS: In a pig model, cardiac arrest was induced by deconnecting from the ventilator. Left lung injury was done by intrabronchial instillation of 1 mL/kg pepsin + HCl. After retrieval, the heart-lung block was stored at 4°C for 2 h. In the treated group, transplantation was performed after reconditioning with intrabronchial diluted surfactant lavage in EVLP system. RESULTS: During EVLP, surfactant group showed better oxygenation and lower pulmonary vascular resistance. After transplantation, better oxygenation, lower mean pulmonary artery pressure, and lower lung edema were observed in surfactant group. Lower blood IL-1 beta and IL-6 cytokine levels were measured in the surfactant group. In bronchoalveolar lavage, the percentage of neutrophils, IL-1 beta and IL-6 cytokine levels, amount of protein, and neutrophil infiltration in the lung tissue at the end of the experiment were significantly lower in the surfactant group. CONCLUSIONS: Our data demonstrate the feasibility of reconditioning and transplantation of an acutely damaged lung graft due to aspiration from a category-3 DCD donor. Implementation of an EVLP system is an efficacious tool to recondition and assess a questionable graft before transplantation.


Assuntos
Lesão Pulmonar/terapia , Transplante de Pulmão , Pulmão/patologia , Pulmão/cirurgia , Perfusão/métodos , Tensoativos/uso terapêutico , Animais , Animais não Endogâmicos , Lavagem Broncoalveolar , Ácido Clorídrico/farmacologia , Ácido Clorídrico/uso terapêutico , Interleucina-1beta/metabolismo , Interleucina-6/metabolismo , Pulmão/efeitos dos fármacos , Modelos Animais , Pepsina A/farmacologia , Pepsina A/uso terapêutico , Tensoativos/farmacologia , Suínos , Resistência Vascular/fisiologia
13.
J Pediatr Hematol Oncol ; 33(2): e64-8, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21285898

RESUMO

BACKGROUND: Long-term tunneled central venous catheters (CVCs) are often the source of catheter-associated bloodstream infections (CABSIs), which may be difficult to eradicate and may lead to premature catheter removal. PROCEDURE: This prospective controlled study used instillation of 2 M hydrochloric acid (HCl) as an adjuvant to the intravenous antibiotic treatment of children with bacteremia and compared the results with those from the immediate preceding period. The primary outcome variable was infection-related CVC removal within 100 days of bacteremia. Only patients with double lumen Hickman CVC with external tubings were included. RESULTS: During a period of 36 months, 109 episodes of bacteremia were treated, 51 during the period where HCl was not used and 58 during the period where HCl was used. Forty-two out of 58 bacteremias were treated with HCl during the "HCl period." An intention-to-treat analysis showed that the median time to infection-related CVC removal was significantly longer during the HCl period compared with the non-HCl period (94 d vs. 12.5 d). At day 100 significantly more CVCs remained in place compared with the non-HCl period. Of the 42 CVCs treated with HCl, 2 had to be removed because of infection before day 30 and further 7 CVCs were removed before day 100. There was no difference in the occurrence of new bacteremias within the first 30 days of bacteremia in the 2 groups. CONCLUSION: HCl may successfully supplement intravenous antibiotics in the treatment of CABSI and contribute to CVC salvage.


Assuntos
Bacteriemia/tratamento farmacológico , Infecções Relacionadas a Cateter/tratamento farmacológico , Cateteres de Demora/efeitos adversos , Ácido Clorídrico/uso terapêutico , Neoplasias/complicações , Antibacterianos/uso terapêutico , Bacteriemia/etiologia , Cateterismo Venoso Central/efeitos adversos , Criança , Pré-Escolar , Remoção de Dispositivo , Humanos , Lactente , Recém-Nascido
14.
Gen Dent ; 58(6): e225-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21062704

RESUMO

Esthetic alterations (such as fluorosis) that result from intrinsic dental staining in enamel and dentin can be controlled or softened by noninvasive methods such as dental bleaching or enamel microabrasion. Part of the enamel is removed during microabrasion; however, this wear is clinically insignificant and does not harm the dental structure. This article presents a case in which the microabrasion technique was used to remove fluorosis staining. Based on the results of this case report, it can be concluded that this technique is efficient and can be considered a minimally invasive procedure.


Assuntos
Microabrasão do Esmalte/métodos , Estética Dentária , Fluorose Dentária/terapia , Adulto , Compostos Inorgânicos de Carbono/uso terapêutico , Profilaxia Dentária/instrumentação , Profilaxia Dentária/métodos , Dentifrícios/uso terapêutico , Microabrasão do Esmalte/instrumentação , Feminino , Humanos , Ácido Clorídrico/uso terapêutico , Compostos de Silício/uso terapêutico , Clareadores Dentários/uso terapêutico , Descoloração de Dente/terapia
15.
Am J Dent ; 20(2): 67-72, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17542197

RESUMO

PURPOSE: To review of the current status of enamel microabrasion method and its results 18 years after the development and application of this method. METHODS: A technique performing enamel microabrasion with hydrochloric acid mixed with pumice and other techniques employing a commercially available compound of hydrochloric acid and fine-grit silicon carbide particles in a water-soluble paste have been described. Much has been learned about the application of this esthetic technique, long-term treatment results and microscopic changes to the enamel surface that has significant clinical implications. The latest treatment protocol is presented and photographic case histories document the treatment results. Clinical observations made over 18 years are discussed. RESULTS: According to our findings, the dental enamel microabrasion technique is a highly satisfactory, safe and effective procedure.


Assuntos
Esmalte Dentário/efeitos dos fármacos , Microabrasão do Esmalte/métodos , Ácido Clorídrico/uso terapêutico , Descoloração de Dente/terapia , Compostos Inorgânicos de Carbono/uso terapêutico , Criança , Esmalte Dentário/química , Materiais Dentários/uso terapêutico , Feminino , Humanos , Masculino , Silicatos/uso terapêutico , Compostos de Silício/uso terapêutico , Descoloração de Dente/tratamento farmacológico
16.
Dent Update ; 34(3): 160-2, 164, 166, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17506456

RESUMO

UNLABELLED: The first article in this series discussed the minimal intervention approach to discoloured teeth, starting with dental bleaching. This second article goes on to explain the technique of microabrasion and the use of direct composite techniques. CLINICAL RELEVANCE: Microabrasion and composite can provide minimally invasive treatments for discoloured teeth.


Assuntos
Abrasão Dental por Ar/métodos , Resinas Compostas , Restauração Dentária Permanente/métodos , Estética Dentária , Descoloração de Dente/terapia , Abrasão Dental por Ar/efeitos adversos , Compostos Inorgânicos de Carbono/uso terapêutico , Cor , Misturas Complexas/uso terapêutico , Resinas Compostas/química , Contraindicações , Humanos , Ácido Clorídrico/uso terapêutico , Ácidos Fosfóricos/uso terapêutico , Silicatos/uso terapêutico , Compostos de Silício/uso terapêutico , Clareamento Dental/métodos , Preparo do Dente/métodos
17.
JBD, Rev. Íbero-Am. Odontol. Estét. Dent. Oper ; 4(14): 131-136, abr.-jun. 2005. ilus, CD-ROM
Artigo em Português | BBO - Odontologia | ID: biblio-851709

RESUMO

A presença de manchas ou descolorações nas estruturas dentárias pode ser, na maioria das vezes, tratada por meio de técnicas de clareamento dentário e/ou microabrasão do esmalte. O procedimento de microabrasão consiste do desgaste superficial do esmalte através da ação de um agente ácido associado a partículas abrasivas, formando uma pasta que é aplicada sobre a superfície dentária por meio de uma ponta abrasiva. Este procedimento promove a remoção de uma pequena camada de esmalte superficial e, consequentemente, das manchas. Para isso, diversas associações de agentes ácidos/abrasivos têm sido preconizadas. O presente relato de caso clínico apresenta a resolução estética de um caso de manchas de fluorese tratado pela técnica da microabrasão, em que se associaram duas técnicas diferentes: macroabrasão e microabrasão com ácido fosfórico a 37%/pedra-pomes na superfície vestibular e ácido clorídrico a 18%/pedra-pomes nas superfícies proximais


Assuntos
Adolescente , Humanos , Feminino , Clareamento Dental/métodos , Microabrasão do Esmalte , Fluorose Dentária , Ácido Clorídrico/uso terapêutico , Estética Dentária , Esmalte Dentário/lesões
18.
Dentum (Barc.) ; 5(1): 12-15, ene.-mar. 2005. ilus
Artigo em Espanhol | IBECS | ID: ibc-84118

RESUMO

La microabrasión del esmalte representa una alternativa terapéutica válida y conservadora frente a defectos superficiales en esmalte. Estos defectos abarcan lesiones que cursan con descalcificación incipiente. Para el procedimiento de microabrasión se utiliza una pasta de ácido clorhídrico al 6,6% y copas abrasivas1 la que aplicada prudentemente genera una remoción uniforme de cantidades insignificantes deesmalte2-6, debido a su efecto erosivo- abrasivo. Así mismo, este procedimiento puede ser complementado con alguna técnica de blanqueamiento dental, para obtener resultados óptimos7,8,que pueden satisfacer los requerimientos estéticos de los pacientes, sin necesidad de recurrir a alternativas terapéuticas restauradoras 8,9 (AU)


The enamel microabrasion is a conservative method available for treatment of surface defects in enamel such as incipient decalcification. In this procedure, hydrochloric acid was applied in a pumice slurry and bristle cups, that correctly applied insignificant and undetectable amount of enamel is uniformly removed due to their “abrosionerosion effects”. In combination with tooth bleaching produce results that may totally satisfy the patient`s esthetic requirements without the need for restorations (AU)


Assuntos
Humanos , Microabrasão do Esmalte/métodos , Ácido Clorídrico/uso terapêutico , Estética Dentária
20.
Cancer ; 101(8): 1866-72, 2004 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-15386305

RESUMO

BACKGROUND: The use of central venous catheters (CVCs) in pediatric cancer patients is associated with substantial risk of producing sepsis. The treatment of catheter-related infections has generally consisted of antibiotic administration with or without catheter removal. The authors report the first published experience using intraluminal hydrochloric acid (HCl) instillation as an adjunct to systemic antimicrobials in the management of catheter-related infections in children with cancer. METHODS: All episodes of intraluminal instillation of 2 M HCl in oncology patients at The Children's Hospital at Westmead between December 1994 and August 2000 were reviewed. Episodes of HCl use were identified from a prospectively maintained infection data base. Successful treatment was defined as no recurrence of infection and no need for CVC removal in the 100 days after HCl administration. RESULTS: Forty-two episodes of HCl instillation were evaluated that occurred in children in whom blood cultures remained positive despite 48 hours of appropriate, systemic antibiotics and formed the basis of this review. All patients had in situ a surgically placed, subcutaneously tunneled CVC. The combination of systemic antibiotic therapy and HCl instillation was successful in eradicating infection in 67% of infection episodes in this patient cohort. The catheter salvage rate was 83% in patients with isolated Gram-negative infections, 75% in patients with isolated fungemia, and 50% in patients with isolated Gram-positive infections. CONCLUSIONS: The results suggest that HCl instillation is a useful adjunct to systemic antibiotic therapy, enabling both catheter salvage and eradication of antibiotic-refractory catheter-related infection.


Assuntos
Bacteriemia , Cateterismo Venoso Central/efeitos adversos , Cateterismo Venoso Central/instrumentação , Fungemia , Ácido Clorídrico/uso terapêutico , Neoplasias/complicações , Anti-Infecciosos/uso terapêutico , Bacteriemia/diagnóstico , Bacteriemia/tratamento farmacológico , Bacteriemia/etiologia , Bactérias/isolamento & purificação , Candida/isolamento & purificação , Criança , Pré-Escolar , Quimioterapia Combinada , Feminino , Fungemia/diagnóstico , Fungemia/tratamento farmacológico , Fungemia/etiologia , Humanos , Lactente , Masculino , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/etiologia , Neoplasias/terapia , Fatores de Risco , Terapia de Salvação
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