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1.
Medicine (Baltimore) ; 100(4): e24191, 2021 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-33530211

RESUMO

BACKGROUND: Parkinson disease (PD), the second most common neurodegenerative disease, has no cure or applicable disease-modifying approach, only symptomatic therapy. Oxidative stress and mitochondrial dysfunction play key roles in PD pathophysiology. Animal studies have demonstrated that photobiomodulation (PBM) may enhance mitochondrial function and boost adenosine triphosphate production, thus alleviating PD symptoms; however, this process can cause increased reactive oxygen species (ROS) production. Molecular hydrogen (H2) is a potent and possibly therapeutic antioxidant that can mitigate the effect of ROS. PBM targeting the brainstem may facilitate neuronal activity, and the concomitant H2 may clear additional ROS produced by PBM. Therefore, this study aimed to determine the safety and effectiveness of PBM + H2 in patients with PD. METHODS: We included 18 patients with PD (age 30-80 years) who were at Hoehn and Yahr stages II-III. All the participants received daily PBM + H2 therapy for 2 weeks. The adverse event and the Unified Parkinson Disease Rating Scale (UPDRS) scores were recorded. RESULTS: We noted that the UPDRS scores began significantly decreasing from the first week, and this improvement persisted until the end of therapy. Moreover, no adverse event was recorded. After 1 week of therapy cessation, UPDRS scores slightly increased but the improvement remained significant compared with the baseline. CONCLUSION: This novel, proof-of-concept study demonstrated that PBM+H2 therapy is safe and reduces disease severity. A larger-scaled clinical trial is warranted to completely investigate the effects of PBM + H2 therapy on PD.


Assuntos
Antioxidantes/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Doença de Parkinson/terapia , Água/administração & dosagem , Água/química , Adulto , Idoso , Idoso de 80 Anos ou mais , Antioxidantes/administração & dosagem , Antioxidantes/efeitos adversos , Terapia Combinada , Método Duplo-Cego , Feminino , Humanos , Hidrogênio/química , Terapia com Luz de Baixa Intensidade/efeitos adversos , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo/fisiologia , Projetos Piloto , Índice de Gravidade de Doença , Água/efeitos adversos
2.
Am J Emerg Med ; 42: 103-109, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33503531

RESUMO

AIM: Low back pain (LBP) is a common musculoskeletal complaint among emergency department (ED) admissions. In this study, it was aimed to compare the effectiveness of systemic treatment with intradermal sterile water injection (ISWI) treatment protocol combined with systemic therapy in patients with LBP of unclear chronicity. METHODS: A prospective randomized, unblinded, controlled clinical study was conducted on patients admitted to the ED for LBP of unclear chronicity. One hundred twelve patients were randomly assigned to two groups; Group ISWI (n = 56) administered ISWI in the LBP region of patients along with systemic intravenous dexketoprofen therapy, while the other group (n = 56) received only systemic intravenous dexketoprofen therapy. The treatment methods' effectiveness was compared by measuring the pain intensity with the Visual Analog Scale (VAS) at admission, 10th minutes, 20th minutes, 30th minutes, and 24 h later. Also, opioid and analgesic consumptions in 24 h after treatment and patient satisfactions were compared. RESULTS: In the treatment of LBP, ISWI treatment was found to be more effective in relieving pain than systemic therapy alone (p < 0.001). Also, it was observed that opioid consumption in the ED and analgesic consumption within 24 h after treatments were decreased in the ISWI group (p < 0.001). The patient satisfaction in the ED was statistically increased (p < 0.001). DISCUSSION: In this unblinded study, ISWI with systemic therapy improved pain outcomes more than systemic therapy alone. Further research is needed to determine whether this was due entirely to placebo effect.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Serviço Hospitalar de Emergência , Cetoprofeno/análogos & derivados , Dor Lombar/terapia , Manejo da Dor/métodos , Trometamina/uso terapêutico , Água/administração & dosagem , Adulto , Analgésicos não Entorpecentes/uso terapêutico , Analgésicos Opioides/uso terapêutico , Anti-Inflamatórios não Esteroides/efeitos adversos , Feminino , Humanos , Injeções Intradérmicas , Cetoprofeno/efeitos adversos , Cetoprofeno/uso terapêutico , Masculino , Pessoa de Meia-Idade , Medição da Dor , Satisfação do Paciente , Estudos Prospectivos , Trometamina/efeitos adversos , Água/efeitos adversos
3.
Biochem Biophys Res Commun ; 535: 1-5, 2021 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-33340760

RESUMO

Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway, and the increased pro-inflammatory cytokines trigger respiratory burst of inflammatory cells that further accelerates ROS production in the inflamed tissue. Such crosstalk between ROS and inflammatory responses leads to a chain reaction of negativity, and cause progression of several chronic pathologies. Since molecular hydrogen is known to preferentially remove cytotoxic hydroxyl radicals and peroxynitrites, and to prevent cell and tissue damage, we here examined whether electrolyzed hydrogen water (EHW) enriched with molecular hydrogen and reactive hydrogen storing platinum nanoparticles dissolved from an electrode could alleviate oxidative stress and inflammation induced by continuous stress challenges. Five-day continuous stress loading to rats elevated reactive oxygen metabolites-derived compounds (d-ROMs), interleukin (IL)-1ß, and adrenocorticotropic hormone (ACTH) levels and decreased the biological antioxidant potential (BAP) level. Drinking EHW during 5-day continuous stress loading significantly alleviated all of these changes. The results suggest that EHW could suppress stress-response-associated oxidative stress and IL-1ß level elevation in vivo, and that drinking of EHW is effective for controlling stress responses via its antioxidant potential.


Assuntos
Anti-Inflamatórios/farmacologia , Antioxidantes/farmacologia , Eletrólise , Hidrogênio/farmacologia , Estresse Oxidativo/efeitos dos fármacos , Água/farmacologia , Hormônio Adrenocorticotrópico/sangue , Animais , Eletrodos , Hidrogênio/administração & dosagem , Inflamação/sangue , Inflamação/tratamento farmacológico , Inflamação/metabolismo , Interleucina-18/sangue , Masculino , Ratos , Espécies Reativas de Oxigênio/metabolismo , Água/administração & dosagem
4.
Nutr. hosp ; 37(5): 1072-1086, sept.-oct. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-198024

RESUMO

Aunque el agua es un nutriente esencial para la vida y el componente más abundante de nuestro cuerpo, recibe escasa atención en las recomendaciones dietéticas y las guías clínicas. Existen inconvenientes para determinar las cifras óptimas, tanto para la cantidad de agua que debe contener el cuerpo como para su ingesta. La ingesta y eliminación del agua dependen de factores no constantes y difíciles de medir, a su vez compensados por la capacidad del organismo para la homeostasis. Dada la falta de evidencia científica para el establecimiento de recomendaciones, se han estimado las "ingestas adecuadas" (para mantener un estado de hidratación adecuado) utilizando datos de ingestas de agua en grupos de personas sanas. La Autoridad Europea de Seguridad Alimentaria (EFSA) también considera la osmolaridad deseable en la orina para estimar la ingesta adecuada de agua en los adultos. Los estudios clínicos han mostrado en general beneficios con una hidratación adecuada y perjuicios con sus desequilibrios, ya sean cuantitativos (deshidratación y sobrehidratación) o cualitativos (agua extracelular e intracelular). Desafortunadamente, estos estudios son escasos y suelen tener diseños deficientes, ya sean transversales, de casos y controles o prospectivos, utilizando muestras pequeñas o métodos indirectos para evaluar el estado de hidratación. En este artículo se presenta información de actualización respecto a: 1) la adherencia a las recomendaciones de consumo de agua y sugerencias para mejorarla; 2) técnicas disponibles para medir el estado de hidratación y sus aplicaciones clínicas; 3) efectos de la hidratación/deshidratación en las actividades físicas o cognitivas y en las enfermedades crónicas; y 4) normativa española sobre calidad y salubridad del agua


Water is an essential nutrient for life and the most abundant component in the human body. However, its dietary recommendations or clinical management guidelines do not receive as much attention as they deserve. In addition, there are some obstacles to establishing optimal values, both for the amount of water the body must contain and for water ingestion. Water intake and elimination depend on unsteady factors that are difficult to measure and, at the same time, compensated by the body's ability to regulate homeostasis. Since scientific evidence is lacking for establishing recommendations, "adequate intakes" (to maintain an adequate hydration state) have been estimated using data on water intake from groups of healthy people. The European Food Safety Authority (EFSA) also considers desirable the use of urine osmolarity to estimate the adequacy of water intake in adults. Clinical studies have generally shown the benefits of adequate hydration and the damage caused by water imbalance, whether quantitative (dehydration and overhydration) or qualitative (extracellular and intracellular water). Unfortunately, these studies are few and often have poor cross-sectional, case-control, or prospective designs, and use small samples or indirect methods to assess hydration status. This article presents up-to-date information on subjects such as: 1) compliance with water consumption recommendations and suggestions for improvement; 2) techniques available to measure hydration status and their clinical applications; 3) effects of hydration/dehydration on physical or cognitive activities and chronic diseases; and 4) existing Spanish regulations on the quality and salubrity of water


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Ingestão de Líquidos/fisiologia , Água/administração & dosagem , Medicina Preventiva , Água Corporal/fisiologia , Necessidades Nutricionais , Composição Corporal/fisiologia , Bebidas , Desidratação/prevenção & controle , Desidratação/terapia , Nível de Saúde , Grupos de Risco
5.
Sci Rep ; 10(1): 6813, 2020 04 22.
Artigo em Inglês | MEDLINE | ID: mdl-32321959

RESUMO

Consecutive adults scheduled to undergo abdominal CT with oral contrast were asked to choose between 1000 ml water only or positive oral contrast (50 ml Télébrix-Gastro diluted in 950 ml water). Two abdominal radiologists independently reviewed each scan for image quality of the abdomen, the diagnostic confidence per system (gastrointestinalsystem/organs/peritoneum/retroperitoneum/lymph nodes) and overall diagnostic confidence to address the clinical question (not able/partial able/fully able). Radiation exposure was extracted from dose reports. Differences between both groups were evaluated by Student's t-test, Mann-Whitney-U-test or chi-square-test. Of the 320participants, 233chose water only. All baseline characteristics, image quality of the abdomen and the diagnostic confidence of the organs were comparable between groups and both observers. Diagnostic confidence in the water only group was more commonly scored as less than good by observer1. The results were as follows: the gastrointestinal system(18/233vs1/87; p = 0.031), peritoneum (21/233vs1/87; p = 0.012), retroperitoneum (11/233vs0/87; p = 0.040) and lymph nodes (11/233vs0/87; p = 0.040). These structures were scored as comparable between both groups by observer2. The diagnostic confidence to address the clinical question could be partially addressed in 6/233 vs 0/87 patients (p = 0.259). The water only group showed a tendency towards less radiation exposure. In summary, most scan ratings were comparable between positive contrast and water only, but slightly favored positive oral contrast for one reader for some abdominal structures. Therefore, water only can replace positive oral contrast in the majority of the outpatients scheduled to undergo an abdominal CT.


Assuntos
Abdome/diagnóstico por imagem , Meios de Contraste/administração & dosagem , Tomografia Computadorizada por Raios X , Água/administração & dosagem , Administração Oral , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Especificidade de Órgãos , Estudos Prospectivos , Exposição à Radiação
6.
J Int Soc Sports Nutr ; 17(1): 20, 2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-32293471

RESUMO

BACKGROUND: This study examined the effects of whey protein supplementation, compared with an isocaloric carbohydrate beverage and water, consumed immediately following an intense swimming trial on bone turnover in adolescent swimmers. METHODS: Fifty-eight (31 female, 27 male) swimmers (14.1 ± 0.4 years) were stratified into three groups matched for age, sex and body mass. The protein and carbohydrate groups consumed two isocaloric post-exercise beverages each containing 0.3 g.kg- 1 of whey protein (with ~ 6 mg of calcium) or maltodextrin while the control group consumed water. Participants provided a morning, fasted, resting blood sample, then performed an intense swimming trial consisting of a maximal 200 m swim followed by a high intensity interval swimming protocol (5x100m, 5x50m and 5x25m; 1:1 work-to-rest ratio). Following swimming, they consumed their first respective post-exercise beverage, and 2 h later, they performed a second maximal swim immediately followed by the second beverage. Approximately 3 h after the second beverage, two post-consumption blood samples were collected at 8 h and 24 h from baseline. Procollagen type 1 intact N-terminal propeptide (PINP) and carboxy-terminal collagen crosslinks (CTXI) were measured in serum. The multiples of medians of PINP and CTXI were also used to calculate bone turnover rate and balance. RESULTS: No significant changes were observed in PINP. CTXI increased (+ 11%) at 8 h in all groups, but then significantly decreased (- 22%) at 24 h in the protein group only. The protein group also had a significantly higher calculated rate of bone turnover at 8 h and 24 h compared to baseline, which was not observed in the other groups. CONCLUSIONS: These results shed light on the potential importance of protein consumed shortly after intense swimming in promoting positive bone turnover responses up to 24 h following exercise in adolescent athletes. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov PRS; NCT04114045. Registered 1 October 2019 - Retrospectively registered.


Assuntos
Remodelação Óssea , Suplementos Nutricionais , Natação , Proteínas do Soro do Leite/administração & dosagem , Adolescente , Bebidas , Método Duplo-Cego , Feminino , Humanos , Masculino , Polissacarídeos/administração & dosagem , Fenômenos Fisiológicos da Nutrição Esportiva , Água/administração & dosagem
7.
Rev. esp. enferm. dig ; 112(4): 258-261, abr. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-187503

RESUMO

INTRODUCCIÓN: la insuflación de dióxido de carbono (CO2) durante la enteroscopia reduce el tiempo del procedimiento y los síntomas posteriores al mismo e incrementa la profundidad de inserción comparado con aire ambiente. En colonoscopia, la técnica de intercambio de agua (IA) se asocia a menor dolor en comparación con la insuflación de CO2. La técnica IA no está bien estudiada en enteroscopia. El objetivo de este estudio es comparar la seguridad y eficacia de la enteroscopia con IA y la enteroscopia con CO2. MÉTODOS: estudio prospectivo, comparativo y observacional, que incluyó enteroscopias de doble balón (EDB) que fueron aleatorizadas en dos grupos: el primero con IA y el segundo con insuflación de CO2. Los datos recopilados se evaluaron mediante análisis univariado y una regresión logística múltiple (variables con p ≤ 0.10 en análisis univariado). RESULTADOS: se incluyeron 46 EDB (23 por brazo; mediana de edad 63,5 años, 37% mujeres). No hubo diferencias estadísticas en la vía de acceso, los hallazgos, la terapéutica y las complicaciones entre grupos. Cuatro pacientes (20%) en el grupo de CO2 tuvieron eventos adversos (distensión abdominal y dolor) y uno en el grupo IA (náuseas) sin diferencia estadística. La mediana de profundidad de inserción fue mayor en el grupo de CO2 (260 cm vs. 160 cm; p = 0,048). La regresión logística múltiple mostró una diferencia estadística en la profundidad de inserción utilizando insuflación de CO2 (OR 1,009, 1,001-1,017; p = 0,034). CONCLUSIONES: las EDB con técnica de insuflación de CO2 y con IA son seguras con una mayor profundidad de inserción con CO2


No disponible


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Ciências da Saúde , Enteroscopia de Balão/métodos , Dióxido de Carbono/administração & dosagem , Hemorragia Gastrointestinal/cirurgia , Água/administração & dosagem , Enteroscopia de Balão/efeitos adversos , Resultado do Tratamento , Estudos Prospectivos , Insuflação/métodos
8.
BMC Res Notes ; 13(1): 103, 2020 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-32098621

RESUMO

OBJECTIVE: Although the eyes occupy 0.1% of the total body surface, eye injuries are serious because vision is arguably the most important sense. We aimed to assess knowledge of Saudi Arabian residents regarding steps to be taken in cases of chemical eye injury, in order to promote awareness of such procedures. RESULTS: A cross-sectional design was done. A random sampling method was utilized to select 888 individuals in the Saudi community. Participants completed an electronic closed ended, validated, anonymous, self-administered questionnaire. Two experts assessed content and face validity. Respondents were 18-29 years of age. 74 (8.3%) had a history of chemical eye injury. Regarding the first step taken in case of chemical eye injury, 697 (78.5%) respondents indicated washing with water, 164 (18.5%) indicated visiting the emergency department, 11 (1.2%) indicated using eye drops, and 5 (0.6%) indicated covering the eye immediately. Seventy-five (8.4%) respondents agreed that an eye injured with an acidic material should be washed with an alkaline solution. These results should be confirmed by health authorities and appropriate interventions should be developed for improving knowledge among masses, thereby promoting a healthier society.


Assuntos
Serviços Médicos de Emergência/métodos , Traumatismos Oculares/diagnóstico , Conhecimentos, Atitudes e Prática em Saúde , Soluções Oftálmicas/administração & dosagem , Inquéritos e Questionários , Água/administração & dosagem , Adolescente , Adulto , Estudos Transversais , Traumatismos Oculares/induzido quimicamente , Traumatismos Oculares/prevenção & controle , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Arábia Saudita , Adulto Jovem
9.
Sci Rep ; 10(1): 1579, 2020 01 31.
Artigo em Inglês | MEDLINE | ID: mdl-32005899

RESUMO

Heat stress is one of the common agrometeorological hazards in rice production in the middle and lower reaches of the Yangtze River in China. To study the mechanism of mist spray in ameliorating heat stress injury, a field experiment was conducted at Nanjing (China) with an early and a late hybrid rice varieties (Oryza sativa L.). The mist spray treatments were conducted at the flowering period, which were at August 6-10 for early rice variety and September 1-5 for late one. Four treatments at different irrigation times (T1: 08:00; T2: 12:00; T3: 14:00; CK: no mist spray; mist spray amount of 1 L·m-2) were included. The temperature and humidity at the different heights of the rice canopy and the net solar radiation above the canopy were measured. The leaf senescence, chlorophyll content, photosynthetic rate and the yields of the rice were determined. The results showed that mist spray rapidly reduced the temperature and increased the relative humidity in the canopy. The cooling effect was most significant at the top of the canopy and decreased downward from the top of canopy. The duration of the temperature decrease caused by the mist spray was 2 h. Mist spray could lead to an increase in latent heat flux (LE) and a decrease in sensible heat flux (H) in the rice field. The mist spray treatments delayed the senescence of the rice leaves, increased the activity levels of the superoxide dismutase, peroxidase, catalase, and soluble protein, reduced the malondialdehyde content, increased leaf chlorophyll content, photosynthetic rate and yield. The T2 treatment showed the most significant effect against heat stress, with the yield of the two varieties increased 13.7 and 13.6% respectively. Compared with mist spray at 08:00 or 14:00, spraying at 12:00 had the strongest resistance to heat stress in rice field.


Assuntos
Produção Agrícola/métodos , Oryza/crescimento & desenvolvimento , Clima , Metabolismo Energético , Resposta ao Choque Térmico , Temperatura Alta , Oryza/fisiologia , Folhas de Planta/fisiologia , Temperatura , Água/administração & dosagem
10.
J Dermatol ; 47(2): 166-168, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31793058

RESUMO

Hematidrosis is a rare disorder involving spontaneous excretion of sweat contaminated by blood cells. We report the case of a 6-year-old girl with hematidrosis from her palms with no underlying disease or psychotic disorder. Before the onset of this symptom, the patient was given an indoor horizontal exercise bar with which she had been frequently playing. This symptom appeared without apparent triggers and was not associated with subjective symptoms. To examine her hematidrosis, metabolites in the red bodily fluid were analyzed using nuclear magnetic resonance analysis. We found the fluid had a metabolome profile similar to that of eccrine sweat. Pathological analysis revealed no abnormal findings, including expression of the tight junction protein claudin 3. Her symptom decreased after treatment with tap-water iontophoresis. Here, we describe our case and discuss its etiology by reviewing previous reports.


Assuntos
Hemorragia/diagnóstico , Hiperidrose/diagnóstico , Iontoforese/métodos , Doenças Raras/diagnóstico , Suor/química , Suor/citologia , Biópsia , Criança , Feminino , Mãos/patologia , Hemorragia/etiologia , Humanos , Hiperidrose/etiologia , Doenças Raras/etiologia , Pele/patologia , Água/administração & dosagem
11.
Urology ; 136: 263-265, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31704457

RESUMO

OBJECTIVE: To find a method of safely inserting a suprapubic catheter (SPC) under local anesthetic and under ultrasound guidance in patients who may not be fit for a general anesthetic but also are seen to have bowel overlying the anterior bladder wall which obscures a safe route to the bladder. MATERIALS AND METHODS: We used ultrasonography to visualize the bladder which was initially filled via the indwelling urethral catheter. A 22-gauge needle attached to a syringe filled with 30 mL of fluid (made up of 10 mL of 1% lidocaine plus 20 mL sterile water) was inserted transabdominally under ultrasound guidance into a space between the pubic symphysis and bowel. The fluid was then injected into the space to hydrodissect the bowel away from the bladder. Once the space had been created, an 18-guage needle was passed into the bladder and a SPC was inserted via the Seldinger technique. RESULTS: Successful SPC insertion was confirmed on ultrasound guidance with no associated bowel or other injury. Telephone follow-up with the patient 6 months later revealed that the patient had no complications and no infections. CONCLUSION: Hydrodissection can be considered when inserting SPC under local anesthetic under ultrasound guidance when there is bowel obscuring any safe route to the bladder. This may be particularly useful in patients who may not be fit for a general an aesthetic.


Assuntos
Cateteres de Demora , Ultrassonografia de Intervenção , Cateterismo Urinário/métodos , Idoso , Dissecação/métodos , Humanos , Masculino , Água/administração & dosagem
12.
Res Vet Sci ; 128: 24-34, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31707097

RESUMO

The effectiveness of 7% hypertonic saline solution (HSS) and 6% hypertonic bicarbonate solution (HBS) followed by intraruminal water administration for the treatment of acute rumen lactic acidosis (ARLA) has not been evaluated yet. The hypothesis of the study is that treatment with HBS causes a faster correction of imbalances and clinical recovery than treatment with HSS. ARLA was induced in six healthy mature female sheep with sucrose twice. The sheep received both treatment regimens in a cross over design. After 18 h of induction, rumen lavage was performed and IV infusion of 7% HSS (4 mL/kg BW) or 6% HBS (6.7 mL/kg BW) was done over 5 min, followed by intraruminal administration of water (8% BW). The solutions provided 4.8 mmol/kg BW of sodium. Physical and laboratory tests were performed for 168 h. Both treatments increased plasma volume. After HSS treatment, pH and HCO3- returned to baseline values at 144 h and BE at 168 h. With HBS treatment, pH returned to baseline at 24 h, and HCO3- and BE at 48 h. In both treatments, the ruminal motility and the maximum hay intake were restored at 96 and 120 h, respectively. In conclusion, administration of HSS or HBS followed by intraruminal water corrects dehydration and mild-to-moderate metabolic acidosis in sheep with ARLA. Treatment with HBS promoted a faster correction of metabolic acidosis and could be indicated for the most severe cases.


Assuntos
Acidose Láctica/veterinária , Bicarbonatos/administração & dosagem , Solução Salina Hipertônica/administração & dosagem , Doenças dos Ovinos/terapia , Cloreto de Sódio/administração & dosagem , Água/administração & dosagem , Acidose Láctica/terapia , Animais , Feminino , Infusões Intravenosas/veterinária , Distribuição Aleatória , Rúmen/fisiopatologia , Ovinos
13.
Ann Emerg Med ; 75(1): 75-85, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31474480

RESUMO

STUDY OBJECTIVE: First-aid guidelines recommend the administration of cool running water in the early management of thermal injury. Our objective is to analyze the associations between first aid and skin-grafting requirements in children with burns. METHODS: This cohort study used a prospectively collected registry of patients managed at a tertiary children's hospital. Multivariate logistic regression models were used to evaluate the relationship between first aid and the requirement for skin grafting. Secondary outcomes included time to re-epithelialization, wound depth, hospital admission and length of stay, and operating room interventions. Adequate first aid was defined as 20 minutes of cool running water within 3 hours of injury. RESULTS: In our cohort of 2,495 children, 2,259 (90.6%) received first aid involving running water, but only 1,780 (71.3%) were given the adequate duration. A total of 236 children (9.5%) required grafting. The odds of grafting were decreased in the adequate first aid group (odds ratio [OR] 0.6; 95% confidence interval [CI] 0.4 to 0.8). The provision of adequate running water was further associated with reductions in full-thickness depth (OR 0.4; 95% CI 0.2 to 0.6), hospital admission (OR 0.7; 95% CI 0.3 to 0.9), and operating room interventions (OR 0.7; 95% CI 0.5 to 0.9), but not hospital length of stay (hazard ratio=0.9; 95% CI 0.7 to 1.2; P=.48). CONCLUSION: Burn severity and clinical outcomes improved with the administration of cool running water. Adequate first aid must be prioritized by out-of-hospital and emergency medical services in the preliminary management of pediatric burns.


Assuntos
Queimaduras/terapia , Primeiros Socorros/normas , Transplante de Pele/estatística & dados numéricos , Água/administração & dosagem , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Escala de Gravidade do Ferimento , Masculino , Guias de Prática Clínica como Assunto , Sistema de Registros , Fatores de Tempo , Resultado do Tratamento
14.
Eur J Nutr ; 59(1): 67-80, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30648220

RESUMO

PURPOSE: The French Nutri-Bébé 2013 study aimed to assess the nutritional intake of infants and young children in comparison with the recommendations of the 2013 European Food Safety Authority (EFSA). METHODS: This cross-sectional study enrolled a random sample of families selected according to the Quota sampling method. A 3-day dietary record was conducted and supervised by two face-to-face interviews. All foods and beverages consumed were qualitatively and quantitatively reported in a diary, and their composition calculated using a food composition database. RESULTS: A total of 1035 non-breastfed children were included. Formula was abandoned early, amounting to approximately 50% of the total food intake at 7 months in 50% of infants and 22% at 1 year. A similar trend was observed for specific complementary foods. After 1 year, 50% of children consumed cow's milk, which was semi-skimmed in 88% of cases. Drinking water intake was low. Protein intake reached 1.4 times the average requirements before 3 months, 2 times at 8-9 months, and > 4 times at 30-35 months. Fat intake was below the EFSA adequate intake (AI) in > 90% of children. Alpha-linolenic acid intake was equal to or greater than the AI in all infants < 3 months, 85% of children at 6 months, 34% at 12-17 months, and 8% >24 months. Regardless of age, docosahexaenoic acid (DHA) intake was less than the AI. CONCLUSION: Strong discrepancies are observed between the actual and recommended intake in young, non-breastfed children namely, a high-protein intake, and a low fat intake, especially DHA.


Assuntos
Registros de Dieta , Dieta/métodos , Ingestão de Energia , Nutrientes/administração & dosagem , Inquéritos Nutricionais/estatística & dados numéricos , Água/administração & dosagem , Pré-Escolar , Estudos Transversais , Feminino , França , Humanos , Lactente , Fórmulas Infantis , Masculino , Inquéritos Nutricionais/métodos
16.
Gen Thorac Cardiovasc Surg ; 68(2): 158-163, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31468277

RESUMO

OBJECTIVE: Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia-reperfusion injury via anti-inflammatory and -oxidative mechanisms. We investigated whether molecular hydrogen-saturated water can preserve lung allograft function in a heterotopic tracheal allograft mouse model of obliterative airway disease METHODS: Obliterative airway disease was induced by heterotopically transplanting tracheal allografts from BALB/c donor mice into C57BL/6 recipient mice, which were subsequently administered hydrogen water (10 ppm) or tap water (control group) (n = 6 each) daily without any immunosuppressive treatment. Histological and immunohistochemical analyses were performed on days 7, 14, and 21. RESULTS: Hydrogen water decreased airway occlusion on day 14. No significant histological differences were observed on days 7 or 21. The cluster of differentiation 4/cluster of differentiation 3 ratio in tracheal allografts on day 14 was higher in the hydrogen water group than in control mice. Enzyme-linked immunosorbent assay performed on day 7 revealed that hydrogen water reduced the level of the pro-inflammatory cytokine interleukin-6 and increased that of forkhead box P3 transcription factor, suggesting an enhancement of regulatory T cell activity. CONCLUSIONS: Hydrogen water suppressed the development of mid-term obliterative airway disease in a mouse tracheal allograft model via anti-oxidant and -inflammatory mechanisms and through the activation of Tregs. Thus, hydrogen water is a potential treatment strategy for BOS that can improve the outcome of lung transplant patients.


Assuntos
Bronquiolite Obliterante/prevenção & controle , Modelos Animais de Doenças , Hidrogênio , Pulmão/fisiopatologia , Traqueia/transplante , Água/administração & dosagem , Obstrução das Vias Respiratórias/etiologia , Aloenxertos , Animais , Bronquiolite Obliterante/fisiopatologia , Ensaio de Imunoadsorção Enzimática , Imunossupressores , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Transplante Homólogo
17.
Molecules ; 25(1)2019 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-31861678

RESUMO

In this study, we present the potential application of deuterium-depleted water (DDW) for the prevention and adjuvant treatment of obesity in rats. We tested the hypothesis that DDW can alleviate diet-induced obesity (DIO) and its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, and level of certain proinflammatory cytokines; decreased levels of insulin in the serum; decreased tryptophan and serotonin in the brain, and a decreased concentration of some heavy metals in the liver. Drinking DDW at a concentration of 10 ppm deuterium/protium (D/H) ad libitum for 3 weeks restored the BWI, glucose (serum), tryptophan (brain), and serotonin (brain) levels and concentration of Zn in the liver in the DIO animals to those of the controls. The levels of proinflammatory cytokines (IL-1ß, IL-6, IFNγ) and anti-inflammatory TNFα were decreased in DIO rats, while anti-inflammatory cytokine (IL-4, IL-10) levels remained at the control levels, which is indicative of a pathophysiological syndrome. In contrast, in groups of rats treated with DDW, a significant increase in anti-inflammatory (IL-4, IL-10) and proinflammatory cytokines (IFNγ) was observed. This finding indicates a reduction in systemic inflammation in obese animals treated with DDW. Similarly, the high-fat diet caused an increased level of oxidative stress products, which was accompanied by decreased activity of both superoxide dismutase and catalase, whereas the administration of DDW decreased the level of oxidative stress and enhanced antioxidant enzyme activities.


Assuntos
Química Encefálica/efeitos dos fármacos , Dieta Hiperlipídica/efeitos adversos , Obesidade/tratamento farmacológico , Água/administração & dosagem , Adjuvantes Farmacêuticos , Animais , Glicemia/efeitos dos fármacos , Citocinas/metabolismo , Deutério/química , Modelos Animais de Doenças , Masculino , Obesidade/induzido quimicamente , Obesidade/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Ratos , Serotonina/metabolismo , Triptofano/metabolismo , Água/farmacologia
18.
Obesity (Silver Spring) ; 27(12): 2037-2045, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31746555

RESUMO

OBJECTIVE: This study aimed to estimate the cost-effectiveness and impact on childhood obesity of installation of chilled water dispensers ("water jets") on school lunch lines and to compare water jets' cost, reach, and impact on water consumption with three additional strategies. METHODS: The Childhood Obesity Intervention Cost Effectiveness Study(CHOICES) microsimulation model estimated the cost-effectiveness of water jets on US childhood obesity cases prevented in 2025. Also estimated were the cost, number of children reached, and impact on water consumption of the installation of water jets and three other strategies. RESULTS: Installing water jets on school lunch lines was projected to reach 29.6 million children (95% uncertainty interval [UI]: 29.4 million-29.8 million), cost $4.25 (95% UI: $2.74-$5.69) per child, prevent 179,550 cases of childhood obesity in 2025 (95% UI: 101,970-257,870), and save $0.31 in health care costs per dollar invested (95% UI: $0.15-$0.55). In the secondary analysis, installing cup dispensers next to existing water fountains was the least costly but also had the lowest population reach. CONCLUSIONS: Installating water jet dispensers on school lunch lines could also save almost half of the dollars needed for implementation via a reduction in obesity-related health care costs. School-based interventions to promote drinking water may be relatively inexpensive strategies for improving child health.


Assuntos
Análise Custo-Benefício/métodos , Obesidade Pediátrica/prevenção & controle , Serviços de Saúde Escolar/economia , Água/química , Criança , Feminino , Humanos , Masculino , Serviços de Saúde Escolar/normas , Água/administração & dosagem
19.
Expert Rev Gastroenterol Hepatol ; 13(12): 1153-1160, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31755802

RESUMO

Introduction: Among the Gastrointestinal (GI) Endoscopy Editorial Board top 10 topics in advances in endoscopy in 2018, water exchange colonoscopy and artificial intelligence were both considered important advances. Artificial intelligence holds the potential to increase and water exchange significantly increases adenoma detection.Areas covered: The authors searched MEDLINE (1998-2019) using the following medical subject terms: water-aided, water-assisted and water exchange colonoscopy, adenoma, artificial intelligence, deep learning, computer-assisted detection, and neural networks. Additional related studies were manually searched from the reference lists of publications. Only fully published journal articles in English were reviewed. The latest date of the search was Aug10, 2019. Artificial intelligence, machine learning, and deep learning contribute to the promise of real-time computer-aided detection diagnosis. By emphasizing near-complete suction of infused water during insertion, water exchange provides salvage cleaning and decreases cleaning-related multi-tasking distractions during withdrawal, increasing adenoma detection. The review will address how artificial intelligence and water exchange can complement each other in improving adenoma detection during colonoscopy.Expert opinion: In 5 years, research on artificial intelligence will likely achieve real-time application and evaluation of factors contributing to quality colonoscopy. Better understanding and more widespread use of water exchange will be possible.


Assuntos
Pólipos Adenomatosos/patologia , Neoplasias do Colo/patologia , Pólipos do Colo/patologia , Colonoscopia/métodos , Aprendizado Profundo , Diagnóstico por Computador , Interpretação de Imagem Assistida por Computador , Água/administração & dosagem , Humanos , Valor Preditivo dos Testes , Reprodutibilidade dos Testes
20.
PLoS One ; 14(10): e0223238, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31600256

RESUMO

There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson's disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and hepatic injury. Moreover, we tested if the co-treatment with an electrolyzed reduced (ERW) was effective to protect against alterations induced by PERM. Rats (from postnatal day 6 to 21) were gavaged daily with PERM, PERM+ERW or vehicle and gut, liver and feces were analyzed in 2-months-old rats. Increased gut permeability, measured by FITC-dextran assay, was detected in PERM group compared to control and PERM+ERW groups. In duodenum and ileum, concentration of occludin was higher in control group than those measured in PERM group, whereas only in duodenum ZO-1 was higher in control than those measured in PERM and PERM+ERW groups. Number of inflammatory focis and neutrophils as well as iNOS protein levels were higher in livers of PERM-treated rats than in those of PERM+ERW and control rats. Fecal microbiota analysis revealed that Lachnospira was less abundant and Defluviitaleaceae more abundant in the PERM group, whereas the co-treatment with ERW was protective against PERM treatment since the abundances in Lachnospira and Defluviitaleaceae were similar to those in the control group. Higher abundances of butyrate- producing bacteria such as Blautia, U.m. of Lachnospiraceae family, U.m. of Ruminococcaceae family, Papillibacter, Roseburia, Intestinimonas, Shuttleworthia together with higher butyric acid levels were detected in PERM+ERW group compared to the other groups. In conclusion, the PD animal model showed increased intestinal permeability together with hepatic inflammation correlated with altered gut microbiota. The positive effects of ERW co-treatment observed in gut, liver and brain of rats were linked to changes on gut microbiota.


Assuntos
Inflamação/tratamento farmacológico , Doença de Parkinson Secundária/tratamento farmacológico , Doença de Parkinson/tratamento farmacológico , Água/administração & dosagem , Animais , Eletrólise , Fezes/microbiologia , Microbioma Gastrointestinal/efeitos dos fármacos , Humanos , Inflamação/induzido quimicamente , Inflamação/complicações , Inflamação/microbiologia , Intestinos/efeitos dos fármacos , Intestinos/microbiologia , Intestinos/patologia , Fígado/efeitos dos fármacos , Fígado/lesões , Fígado/patologia , Doença de Parkinson/complicações , Doença de Parkinson/microbiologia , Doença de Parkinson Secundária/induzido quimicamente , Doença de Parkinson Secundária/complicações , Doença de Parkinson Secundária/microbiologia , Permeabilidade/efeitos dos fármacos , Permetrina/toxicidade , Ratos , Água/química
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