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1.
Artigo em Russo | MEDLINE | ID: mdl-33605130

RESUMO

Moscow in modern borders is the largest metropolitan area in the country with a fairly high and unevenly distributed population density. This predetermines the need to address environmental regulation of urbanization in order to create the most comfortable living conditions for the population. Health care and the maintenance of health of all age groups are the leading role in the list of the most important tasks to ensure the social well-being of citizens. In the bowels of the Moscow region there are natural therapeutic resources: low-mineralized (M 3-5 g/l) sulfate sodium-magnesium-calcium drinking mineral water and chloride sodium bromine brine. The article presents the characteristics of the natural therapeutic resources of the Moscow region, the area of their therapeutic use, justified the possibility of wider use based on the available scientific data on the effect on the body of these waters and their analogues. All this provides an opportunity to achieve the main goal of medical resortology - the use of mineral water as a means of therapy, rehabilitation and prevention of most existing human diseases.


Assuntos
Água Potável , Água Subterrânea , Águas Minerais , Água Potável/análise , Humanos , Águas Minerais/análise , Moscou , Turismo
2.
Shokuhin Eiseigaku Zasshi ; 61(2): 72-76, 2020.
Artigo em Japonês | MEDLINE | ID: mdl-32336712

RESUMO

We used ion chromatography with post column derivatization to measure chromium (VI) concentrations in 155 mineral water (MW) products purchased from markets in Japan in 2018. Chromium (VI) recovery in spiked samples of the 155 MW products ranged from 95 to 106%, suggesting that this method is well suited for ensuring that MW products meet the requisite health and food safety standards. Chromium (VI) levels were above detection limits in 54 of the MW products, giving a total detection rate of 35%. The minimum and maximum chromium (VI) concentrations in all of the MW products were 0.0001 mg/L and 0.045 mg/L, respectively. The median chromium (VI) concentration was 0.0003 mg/L, with most MW products having chromium (VI) concentrations in the range of 0.0001 to 0.0002 mg/L. None of the MW products had chromium (VI) concentrations that exceeded the current standard value (0.05 mg/L) for MW in Japan.


Assuntos
Cromo/análise , Água Potável/análise , Águas Minerais/análise , Japão
3.
Wei Sheng Yan Jiu ; 49(1): 112-117, 2020 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-32290925

RESUMO

OBJECTIVE: The method for analyzing of 20 polychlorinated biphenyls(PCBs) in water by stable isotope internal standard-automatic solid-phase extraction membrane(auto SPEM) coupled to gas chromatography-mass spectrometer(GC-MS) was established, and applied to the analysis of trace PCBs in water samples. METHODS: The sample backgrounds of bottled mineral water production in Fuzhou(groundwater), inland water in Fuzhou university city(surface water), tap water(pipe tip water) and stream water in Xiyuan Gong(water source of life) were analyzed by GC-MS. Surrogate solution(SS)internal standards including ~(13)C_(12 )PCBs stable isotope was used for quantification. The method was confirmed by calculating recovery rate(RR) and relative standard deviation(RSD) of spiked water samples(20, 40 and 80 ng/L, n=7). And recovery rates of SS were used to evaluate the effect of the pretreatment. And the method was used to determine PCBs of a total of 17 cross-sectiona river water in minjiang river tributaries upstream to the downstream estuary. RESULTS: The method detection limits(MDL) were 1. 9-6. 6 ng/L, and RRs were 70. 9%-127%, and RSDs were 0. 5%-13%. The RRs of SS were 40%-90%. Positive sample was not detected. CONCLUSION: The method of auto SPEM is less solvent, more automatic than traditional manual SPE. And the method is more accurate and reliable by stable isotope internal standard coupled to GC-MS. Therefore, it is useful for the trace PCBs determination of waters.


Assuntos
Bifenilos Policlorados/análise , Poluentes Químicos da Água/análise , China , Água Potável/análise , Cromatografia Gasosa-Espectrometria de Massas , Água Subterrânea/análise , Técnicas de Diluição do Indicador , Isótopos , Águas Minerais/análise , Rios/química , Extração em Fase Sólida
4.
Curr Urol Rep ; 21(1): 6, 2020 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-32016596

RESUMO

PURPOSE OF REVIEW: The role of the mineral constituents in water and their role in kidney stone disease (KSD) have been a long-standing subject of debate. The aim of our systematic review was to evaluate the relevance of different types of water in stone disease. RECENT FINDINGS: Studies to date have had varying results regarding the importance of hardness of water which is mostly determined by its calcium content. Other elements including magnesium and bicarbonate also play a crucial role in prevention of renal stones. Patients with stone disease are provided varying advice due to a lack of consensus on the types of water recommended. Increased fluid intake prevents stone formation. Our review of the literature suggests that hard water and bottled mineral water might be helpful for calcium stone formers. High calcium content in them leads to hypercalciuria; however, other factors also influence stone formation and the overall impact seems to be a reduction in calcium stone formation. The mineral content varies across different water types but high magnesium and bicarbonate content in water is also recommended for kidney stone patients.


Assuntos
Cálcio/análise , Água Potável , Cálculos Renais/prevenção & controle , Águas Minerais/uso terapêutico , Bicarbonatos/análise , Ingestão de Líquidos , Água Potável/química , Humanos , Cálculos Renais/etiologia , Cálculos Renais/terapia , Magnésio/análise , Águas Minerais/análise
5.
Molecules ; 25(3)2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-32019189

RESUMO

Nanoemulsions are submicron-size colloidal systems that have the ability to encapsulate, protect, and deliver active ingredients. They have been used in the pharmaceutical, cosmetics, and food industries to improve the absorption of drugs by the skin or via the gastrointestinal tract, aide in food conservation, and treat skin problems. To proper formulate a nanoemulsion, it is important to know the characteristics of its components (aqueous and oil phases, surfactants and additives), as well as the influence on the production method that will be used. This study investigates the influence of aqueous phase composition, stability and particle size in an oil-and-water nanoemulsion formation. By using a low energy method, the purified water was exchanged for different commercial mineral water and saline solutions, and the results of stability, particle size, pH and conductivity tests, were compared. These results show that the minerals present in commercial waters may alter the particle size, pH and conductivity values of nanoemulsions, as well as their stability.


Assuntos
Emulsões/química , Águas Minerais/análise , Nanoestruturas/química , Óleos/química , Tensoativos/química , Concentração de Íons de Hidrogênio , Termodinâmica
6.
Int J Mol Med ; 45(2): 658-668, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31894254

RESUMO

Mineral­balanced deep sea water (MBDSW), an unlimited natural sea source, has been demonstrated to minimize the risk of developing cardiovascular diseases, such as obesity, hypertension, inflammation and hyperlipidemia. This study investigated the effects of MBDSW [magnesium (Mg):calcium (Ca) ratio, 3:1] on platelet activation. MBDSW significantly inhibited the collagen­ and thrombin­induced platelet aggregation of human platelets. In collagen­induced platelets, MBDSW inhibited intracellular calcium mobilization, granule secretion [serotonin, adenosine triphosphate (ATP) and P­selectin expression] and thromboxane A2 (TXA2) production. Moreover, MBDSW markedly inhibited Akt and extracellular signal­regulated kinase (ERK) phosphorylation, but not that of c­Jun N­terminal kinase (JNK) and p38. Moreover, MBDSW phosphorylated inositol 1,4,5­triphosphate receptor (IP3R) and vasodilator­stimulated phosphoprotein (VASP), and it increased the cyclic adenosine monophosphate (cAMP) level in collagen­induced human platelets. Dipyridamole, a phosphodiesterase (PDE) inhibitor, significantly increased the cAMP level and regulated the Akt, ERK and VASP (Ser157) levels in a manner similar to that of MBDSW. In addition, LY294002, an Akt inhibitor, inhibited the phosphorylation of ERK, and U0126, an ERK inhibitor, inhibited the phosphorylation of Akt. Taken together, the results of the present investigation suggest that the inhibitory effects of MBDSW on platelet aggregation may be associated with the cross­inhibition of Akt and ERK phosphorylation. These results strongly indicate that MBDSW may have preventive or therapeutic potential for platelet aggregation­mediated diseases, such as thrombosis, atherosclerosis and myocardial infarction.


Assuntos
Águas Minerais , Inibidores da Agregação de Plaquetas/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Água do Mar , Plaquetas/citologia , Plaquetas/efeitos dos fármacos , Plaquetas/metabolismo , MAP Quinases Reguladas por Sinal Extracelular/metabolismo , Humanos , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Águas Minerais/análise , Inibidores da Agregação de Plaquetas/análise , Proteínas Proto-Oncogênicas c-akt/metabolismo , Água do Mar/análise , Transdução de Sinais/efeitos dos fármacos
7.
Environ Geochem Health ; 42(7): 2039-2057, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31776886

RESUMO

The common therapeutic indications of Portuguese Natural Mineral Waters (NMWs) are primarily for respiratory, rheumatic and musculoskeletal systems. However, these NMWs have been increasingly sought for dermatologic purposes. Opposing to what is observed in the major European Thermal Centres, there are few scientific evidences supporting the use of Portuguese NMWs for clinical applications. The aim of this study was to characterize the antimicrobial profile of individual NMWs from the central region of Portugal and correlate the results with their physicochemical characterization. An extensive multivariate analysis (principal component analysis) was also performed to further investigate this possible correlation. Six collection strains representing skin microbiota, namely Staphylococcus aureus, Escherichia coli, Corynebacterium amycolatum, Candida albicans, Staphylococcus epidermidis and Cutibacterium acnes, were analysed, and their antimicrobial profile was determined using Clinical and Laboratory Standards Institute M07-A10, M45-A2, M11-A6 and M27-A3 microdilution methods. Different NMWs presented different antimicrobial profiles against the strains used; the physicochemical composition of NMWs seemed to be correlated with the different susceptibility profiles. Cutibacterium acnes showed a particularly high susceptibility to all NMWs belonging sulphurous/bicarbonated/sodic ionic profile, exhibiting microbial reductions up to 65%. However, due to the complex physicochemical composition of each water an overall conclusion regarding the effect of a specific ion on the growth of different microorganisms is yet to be known.


Assuntos
Anti-Infecciosos/farmacologia , Águas Minerais/análise , Águas Minerais/uso terapêutico , Pele/microbiologia , Corynebacterium/efeitos dos fármacos , Escherichia coli/efeitos dos fármacos , Humanos , Testes de Sensibilidade Microbiana , Microbiota , Portugal , Análise de Componente Principal , Propionibacterium acnes/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus epidermidis/efeitos dos fármacos
8.
Environ Geochem Health ; 42(2): 353-364, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31630285

RESUMO

Medicinal mineral water, being provided by recognized immunosuppressive properties, results useful for treating many pathological conditions. A well-known source of sulfurous and oligomer medicinal mineral waters is located in Caramanico Terme (Pescara, Italy). Caramanico Terme is a small town in the Majella's National Park, and its precious and peculiar environment offers a medicinal mineral water (also known as cures or crenotherapy), that since 1576 is administrated to a large number of patients (around 15,000 per year). However, no scientific conclusions on the efficacy of Caramanico's Terme medicinal mineral water properties are available. Therefore, we have carried out an epidemiological study, enrolling a population of 370 subjects that have received crenotherapy. Such a population has been also compared to a control group of individuals (untreated, N = 287), never undergone any medicinal mineral water administration. Detailing the geomorphological characteristics of Caramanico Terme environment, we have also analyzed the results of the study that showed that pathology-relapses, as well as related manifestations of symptoms and drug employments, were largely reduced after one or more cycles of crenotherapy. On the other hand, a sub-group of subjects receiving crenotherapy for more than 5 years (N = 166) presented a highly reduced prevalence of a large spectrum of pathologies (cardiovascular, inflammatory, neurological and cancer diseases), with respect to an overlapping population (in terms of age and genders) of untreated subjects. We have also clarified the role of aging and long-term effects of medicinal mineral-water administration. Altogether, these data indicated that the clinical employment of Caramanico's Terme medicinal mineral water produces short- as well as long-term beneficial effects, both with respect to the amelioration of life quality of patients and in reducing the probability to develop major disabling pathologies (i.e., cardiovascular, cancer and neurological diseases). Therefore, these data will open novel strategies for a larger application of crenotherapy.


Assuntos
Balneologia/métodos , Águas Minerais/administração & dosagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Balneologia/estatística & dados numéricos , Criança , Pré-Escolar , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Águas Minerais/análise , Minerais/análise , Resultado do Tratamento , Adulto Jovem
9.
Talanta ; 206: 120207, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31514857

RESUMO

Herein, a multicommuted flow-batch setup and a photometric procedure for the determination of mercury at the ppb level in aqueous samples are described. The setup was designed to implement a versatile solvent extraction and pre-concentration strategy by combining flow-batch and multicommuted flow analysis approaches. The photometric method was based on Hg(II) reaction with dithizone in a chloroform medium, which was also used as the extracting organic solvent. The flow analysis system was composed of a homemade syringe pump module, a set of solenoid valves, two Aquarius mini-pumps, and a flow-batch chamber. The homemade photometer was comprised of a light emitting diode (LED), photodiode, and homemade flow cell (50 mm length). The flow system and photometer were controlled using an Arduino Due board, running custom-written software. After optimizing the operational conditions, the effectiveness of the developed system was evaluated for the determination of the mercury concentration in drinking water. For accuracy assessment, samples were analyzed using a spiking methodology and an independent method, yielding a recovery ranging from 92% to 108%. Other important characteristics of the proposed method were found as follows: linear response range, 0.5-10.0 µg L-1 (r = 0.9984); limit of detection 0.38 µg L-1 Hg(II); consumption of dithizone and chloroform, 1.85 µg L-1 and 0.8 mL per analysis, respectively; coefficient of variation, 2% (n = 10); sampling throughput, 20 determinations per h.


Assuntos
Água Potável/análise , Mercúrio/análise , Fotometria/métodos , Poluentes Químicos da Água/análise , Clorofórmio/química , Ditizona/química , Química Verde/instrumentação , Química Verde/métodos , Limite de Detecção , Águas Minerais/análise , Fotometria/instrumentação , Rios/química
10.
Sensors (Basel) ; 20(24)2020 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-33419266

RESUMO

Hormones have a harmful impact on the environment and their detection in water bodies is an urgent matter. In this work, we present and analyze a sensor device able to detect traces of the synthetic hormone 17α-ethinylestradiol (EE2) below 10-9 M in media of different complexities, namely, ultrapure, mineral and tap waters. This device consists of solid supports with interdigitated electrodes without and with a polyethylenimine (PEI) and poly (sodium 4-styrenesulfonate) (PSS) layer-by-layer film deposited on it. Device response was evaluated through capacitance, loss tangent and electric modulus spectra and the data were analyzed by principal component analysis method. While the three types of spectra were demonstrated to be able to clearly discriminate the different media, loss tangent spectra allow for the detection of EE2 concentration, with a sensitivity of -0.072 ± 0.009 and -0.44 ± 0.03 per decade of concentration, for mineral and tap water, respectively. Detection limits values were found to be lower than the ones present in the literature and presenting values of 8.6 fM (2.6 pg/L) and of 7.5 fM (22.2 pg/L) for tap and mineral waters, respectively. Moreover, the obtained response values follow the same behavior with EE2 concentration in any medium, meaning that loss tangent spectra allow the quantification of EE2 concentration in aqueous complex matrices.


Assuntos
Água Potável/análise , Etinilestradiol , Águas Minerais/análise , Poluentes Químicos da Água , Etinilestradiol/análise , Poluentes Químicos da Água/análise
11.
Rev Esp Salud Publica ; 932019 12 17.
Artigo em Espanhol | MEDLINE | ID: mdl-31844039

RESUMO

OBJECTIVE: The daily consumption of fluoridated water is one of the most beneficial measures in dental caries prevention. The objective of this paper was to analyze the content of fluorine and heavy metals in the bottled natural mineral water available in stores in Spain. METHODS: A descriptive and transversal study was done throughout 2019. Analysing a total of 20 bottled waters marketed in Spain during this year. Mainly, fluoride concentration (ppm/ml) was analyzed with an ion-specific electrode (Orion model 96-09, Orion Research, Cambridge, MA) coupled to an ion analyzer (Orion EA-940). The heavy metals were analyzed by ICP-MS (Agilent model 7900). A descriptive statistical study of the data was carried out. RESULTS: The minimum value of fluorine found was 0.05 ppm and the maximum 0.95ppm. 80% of the brands analyzed contain less than 0.6 ppm F. Only 1 brand exceeds 0.8 ppm F. Chromium and arsenic were the heavy metals present in all brands, without exceeding the maximum dose. No brand of bottled water indicated heavy metals on the label, and only 1 mark indicated the fluoride concentration on the label. CONCLUSIONS: There is a great variability in the chemical composition of bottled waters marketed in Spain. Most have a fluoride concentration lower than that recommended to prevent tooth decay, which would require an extra supply of fluoride. In the bottled waters analyzed there are heavy metals but they did not exceed the maximum doses established by legislation.


Assuntos
Cárie Dentária/prevenção & controle , Água Potável/química , Fluoretos/análise , Fluorose Dentária/prevenção & controle , Metais Pesados/análise , Águas Minerais , Poluentes Químicos da Água/análise , Estudos Transversais , Cárie Dentária/etiologia , Água Potável/análise , Fluorose Dentária/etiologia , Humanos , Águas Minerais/análise , Espanha , Qualidade da Água
12.
Environ Monit Assess ; 191(12): 749, 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31728744

RESUMO

Twelve different brands of mineral water were collected from the Algerian market and analyzed to determine the initial antimony (Sb) content in both the PET package and mineral water. Experiments were conducted under different time conditions: 1, 10, to 365 days, different temperatures: 6, 25, and 40 °C, and different bottles sizes: 0.33 L and 1.5 L. The Sb in mineral water bottles varies between 0.50 and 1.12 µg/L for 0.33 L bottles, and 0.37 to 0.77 µg/L for 1.5 L ones. All of these values remain below the limit set by the European Union of 5 µg/L in drinking water. The diffusion coefficient of Sb in PET has been experimentally determined at 6, 25, and 40 °C, after the content of Sb in 1.5 L PET bottles had been determined. In the second part of the study, a factorial design 23 enabled a model the migration of antimony (Sb) in the bottled solutions and highlighted the influencing effects, such as temperature (°C), time (h), and thickness (mm) for two different time domains encompassing the entire validity period of the product. A simple polynomial function based on a single parameter has been determined with a precision indicator R2 = 0.98. This model has the advantage of being simple and fast. The Chronic Daily Intake (CDI) of Sb has been calculated, for adults. It does not exceed the Environmental Protection Agency (USEPA) regulated CDI value of 400 ng/kg/day. The CDI values for children increase as the weight of the children decreases. The passage from the maximum child weight to the minimum value in the study increases the CDI of 77%.


Assuntos
Antimônio/análise , Água Potável/química , Monitoramento Ambiental/métodos , Águas Minerais/análise , Plásticos/química , Polietilenotereftalatos/química , Poluentes Químicos da Água/análise , Adulto , Criança , Humanos , Tomografia por Emissão de Pósitrons , Temperatura
13.
Environ Monit Assess ; 191(11): 648, 2019 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-31624912

RESUMO

The goal of this study is to evaluate the quality of seven natural mineral water sources in the Vrnjacka Banja area used in the treatment of various diseases. The 24 macro- and microelements were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The results show that element content was within allowed limits of concentration, except for B, As, and Se. The evaluated content of these elements can be associated with geological and anthropogenic factors. The sample S6 contains more than twice the concentration of As, meaning that the use of water from this source should be limited due to the negative impact of this element on human health. The calculated values of weekly (EWI) and oral (OI) intakes as well as the acute hazard quotient (HQA) of selected toxic and potentially toxic elements indicate no health risks to the consumers. The highest hazard quotient (HQL) observed for As in sample S6 (2.0·10-1) demonstrated a significant risk of carcinogenic diseases in long-term consumption from this source. The estimated non-carcinogenic (DIA) and carcinogenic (DIL) dermal intakes with acute (HQA) and long-term (HQL) hazard quotient values for sample S3 show that there is no health risk to those who use the water from this thermal source for bathing. The presence of aerobic mesophilic bacteria at 22 °C and 37 °C in samples S3, S6, and S7 as well as sulphite-reducing Clostridia species in sample S5 were detected, potentially indicating some non-faecal or faecal contamination.


Assuntos
Monitoramento Ambiental/métodos , Águas Minerais/análise , Águas Minerais/microbiologia , Minerais/análise , Poluentes Químicos da Água/análise , Qualidade da Água , Saúde , Humanos , Medição de Risco , Sérvia
14.
Sci Rep ; 9(1): 14252, 2019 10 03.
Artigo em Inglês | MEDLINE | ID: mdl-31582775

RESUMO

Since 2013, the Council Directive 2013/51/Euratom has been regulating the content of radioactive substances in water intended for human consumption. However, mineral waters are exempted from this regulation, including self-bottled springs waters, where higher radon concentration are expected. Therefore, a systematic survey has been conducted on all the 33 mineral spring waters of Lazio (a region of Central Italy) in order to assess if such waters, when self-bottled, may be of concern for public health. Waters have been sampled in two different ways to evaluate the impact of bottling on radon concentration. Water sampling was possible for 20 different spring waters, with 6 samples for each one. The results show that 2 (10%) of measured mineral spring waters returned radon concentrations higher than 100 Bq L-1, i.e., the parametric value established by the Council Directive. These results, if confirmed by other surveys involving a higher number of mineral spring waters, would suggest regulating also these waters, especially in countries like Italy for which: (i) mineral water consumption is significant; (ii) mineral concession owners generally allow the consumers to fill bottles and containers, intended for transport and subsequent consumption, directly from public fountains or from fountains within the plant; (iii) the consumers' habit of drinking self-bottled mineral water is widespread.


Assuntos
Água Potável/análise , Águas Minerais/análise , Radônio/análise , Poluentes Radioativos da Água/análise , Água Potável/efeitos adversos , Humanos , Itália , Águas Minerais/efeitos adversos , Saúde Pública , Radônio/efeitos adversos , Poluentes Radioativos da Água/efeitos adversos , Abastecimento de Água/métodos
15.
J Nutr ; 149(11): 1994-2000, 2019 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-31373351

RESUMO

BACKGROUND: Our previous study found that consumption of very low mineral drinking water may retard height development in schoolchildren; however, its association with bone modeling remained unknown. OBJECTIVES: The aim of this study was to investigate the influence of very low mineral water on biomarkers of bone modeling in children. METHODS: A retrospective cohort study was conducted among 2 groups of 10-13-y-old children who had consumed drinking water with normal mineral contents (conductivity 345 µs/cm, the NW group including 119 boys and 110 girls) or very low mineral contents (conductivity 40.0 µs/cm, the VLW group including 223 boys and 208 girls) in school for 4 y. Differences in daily total mineral intakes, developmental parameters, serum biomarkers of osteoblast activity, and bone formation and resorption between the 2 groups were analyzed with independent t test and chi-square test. Associations of developmental parameters and serum biomarkers with Ca intake from drinking water were analyzed with multiple linear regression and binary logistic regression. RESULTS: Compared with the NW group, the VLW group had lower daily Ca intake, height increase, bone mineral content (BMC), osteoblast activity [serum bone alkaline phosphatase (BALP)] (means ± SDs: 433 ± 131 mg, 16.6 ± 8.27 cm, 1.92 ± 0.431 kg, and 9.28 ± 1.42 µg/L compared with 497 ± 155 mg, 22.3 ± 8.45 cm, 2.14 ± 0.354 kg, and 11.0 ± 0.823 µg/L, respectively, P < 0.001), and higher bone resorption [serum crosslinked C-telopeptide of type I collagen (CTX), mean ± SD: 142 ± 46.9 nmol/L compared with 130 ± 40.6 nmol/L, P = 0.001). Ca intake from drinking water was positively associated with height increase, BMC, and BALP (ß: 0.0667, 95% CI: 0.0540, 0.0793; ß: 3.22, 95% CI: 2.37, 4.08; and ß: 23.9, 95% CI: 20.6, 27.2), respectively, P < 0.001), and was negatively associated with CTX (ß: -0.206, 95% CI:-0.321, -0.0904, P < 0.001). CONCLUSIONS: These changes suggested that consumption of very low mineral water may be associated with osteoblast inhibition, bone resorption activation, bone mineral reduction, and height development retardation. The health risk of consuming very low mineral water should be considered in children.


Assuntos
Densidade Óssea/efeitos dos fármacos , Densidade Óssea/fisiologia , Água Potável/administração & dosagem , Águas Minerais/administração & dosagem , Adolescente , Fosfatase Alcalina/sangue , Biomarcadores/sangue , Estatura/efeitos dos fármacos , Estatura/fisiologia , Desenvolvimento Ósseo/efeitos dos fármacos , Desenvolvimento Ósseo/fisiologia , Remodelação Óssea/efeitos dos fármacos , Remodelação Óssea/fisiologia , Cálcio na Dieta/administração & dosagem , Cálcio na Dieta/análise , Criança , Estudos de Coortes , Colágeno Tipo I/sangue , Água Potável/análise , Feminino , Humanos , Magnésio/sangue , Masculino , Águas Minerais/análise , Peptídeos/sangue , Estudos Retrospectivos
16.
Methods Mol Biol ; 2027: 49-59, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31309471

RESUMO

Photochromic molecules can respond to external stimulations and undergo reversible conversion between different chemical structures, providing one photochromic molecule with multiple recognition states for targeting compounds. Here we design a facile sensor microchip with only one photochromic molecule (spirooxazine) to discriminate multiplex metal ions. The sensor chip performs in dark, ultraviolet, or visual stimulation, resulting in different molecular states of spirooxazine-metallic coordination and patterned fluorescent signals for analysis. By using this sensor microchip, 11 metal ions are discriminated. Furthermore, mineral water of 16 different brands and metal ions in human serum are distinguished.


Assuntos
Ensaios de Triagem em Larga Escala/instrumentação , Íons/sangue , Metais/sangue , Análise em Microsséries/instrumentação , Benzodiazepinonas , Corantes Fluorescentes/química , Compostos Heterocíclicos de 4 ou mais Anéis , Humanos , Íons/química , Metais/química , Águas Minerais/análise , Oxazinas/química , Compostos de Espiro/química
17.
Environ Monit Assess ; 191(7): 452, 2019 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-31218433

RESUMO

This study monitors the elemental composition of different brands of bottled natural mineral waters marketed in Turkey and discusses compositional parameters. Natural mineral water samples were analyzed for cesium (Cs), rubidium (Rb), thallium (Tl), cobalt (Co), arsenic (As), chromium (Cr), lead (Pb), gallium (Ga), vanadium (V), silver (Ag), cadmium (Cd), uranium (U), thorium (Th), and molybdenum (Mo) by inductively coupled plasma mass spectrometry (ICP-MS). Method trueness was confirmed by using 1640A natural water certified reference materials purchased from Laboratory of the Government Chemist (LGC). The linearity, limit of detection, limit of quantification, repeatability, and recovery (%) were assessed. Method validation data and results obtained from the certified reference material suggested that the method could be applied to determine elemental contaminants of the samples. Cd, Tl, Ag, and Th could not be determined (< LOD) in the samples. Pb, Cs, Co, Rb, Ga, V, U, As, Cr, and Mo were determined in samples. The results were compared with elemental standards for natural mineral waters set according to the World Health Organization and United States Environmental Protection Agency, and the concentrations of all metals did not exceed these values.


Assuntos
Arsênico/análise , Água Potável/análise , Metais Pesados/análise , Águas Minerais/análise , Poluentes Químicos da Água/análise , Monitoramento Ambiental , Espectrometria de Massas/métodos , Turquia
18.
Food Chem ; 292: 151-159, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31054660

RESUMO

A simple and fast solid phase microextraction method using magnetic dextran (Sephadex G-150) as a sorbent was developed for the extraction, separation and speciation analysis of chromium ions. The retained Cr(VI) ions on the magnetic dextran sorbents were eluted and detected by linear sweep voltammetry at the gold nanoparticles modified screen- printed carbon electrode. The linear range, detection limit, quantification limit, and preconcentration factor of the established method for Cr(VI) and Cr(III) were calculated to be 0.5-10 µM, 0.01 µM, 0.1 µM, and 40, respectively. Chromium(III) concentration was determined after conversion of Cr(III) to Cr(VI) by H2O2 in alkaline media (NH4OH). The method was successfully applied to the speciation and determination of Cr(VI) and Cr(III) in artificial water and food samples using the standard addition method. The applicability of the method was confirmed by analysis of real food samples yielding good recovery values (92% and 102%).


Assuntos
Bebidas/análise , Cromo/análise , Nanopartículas de Magnetita/química , Águas Minerais/análise , Extração em Fase Sólida/métodos , Adsorção , Cromo/isolamento & purificação , Dextranos/química , Óxido Ferroso-Férrico/química , Peróxido de Hidrogênio/química , Concentração de Íons de Hidrogênio , Limite de Detecção , Reprodutibilidade dos Testes
19.
Food Chem ; 294: 405-413, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31126481

RESUMO

In the present paper, a new analytical preconcentration/speciation method for antimony species determination in bottled mineral water samples using the SiO2/Al2O3/SnO2 adsorbent was developed. The method is based on selective adsorption of Sb(III) ions by SiO2/Al2O3/SnO2 under a wide pH range (2.5-7.5). Total antimony was determined with previous sample treatment using 0.1% (w/v) l-cysteine and the concentration of Sb(V) species was determined by the difference between total and Sb(III). The proposed method provided an analytical curve ranging from 0.50 to 5.00 µg L-1 (r = 0.999), limit of detection (LD) of 0.17 µg L-1 and preconcentration factor (PF) of 136-fold. The method exhibited tolerance to different metal ions and the accuracy was attested from addition and recovery tests (95.2-106.0%) in bottled mineral water samples using 2.0% (w/v) l-cysteine, as well as by analysis of certified material. Only Sb(III) species were determined in mineral water (0.54-1.04 µg L-1).


Assuntos
Antimônio/análise , Água Potável/análise , Águas Minerais/análise , Espectrofotometria Atômica/métodos , Óxido de Alumínio/química , Antimônio/química , Cisteína/química , Análise de Injeção de Fluxo , Limite de Detecção , Oxirredução , Dióxido de Silício/química , Compostos de Estanho/química
20.
Molecules ; 24(7)2019 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-30934973

RESUMO

Iodine is an essential nutrient necessary for the production of thyroid hormones. A valuable source of iodide, which is the bio-available iodine form could be mineral waters offered by different spas. In this work, the method capable of direct determination of iodide in mineral water samples based on IAM liquid chromatography on the phosphatidylcholine column (IAM.PC.DD2 Regis HPLC) with DAD detection without sample pretreatment or any pre-concentration steps is presented. The calibration graph for iodide was linear in the range of 0.5⁻10.0 mg L-1 with a correlation coefficient of 0.9996. The limit of detection was 22.84 ng mL-1. The relative recoveries were in the interval of 98.5⁻100.2% and the repeatability, expressed as a relative standard deviation (RSD) was less than 5%. The RSA (Response Surface Analysis) investigated the effect of the sample concentration and the injection volume. The iodide concentrations in the mineral water samples ranged from 0.58 to 2.88 mg L-1. The accuracy of the method was assessed through independent analysis by ICP-MS. Iodide levels measured by these two procedures did not significantly differ. The effects of interfering ions like HCO3-, Cl-, SO42-, F-, and Br- were also tested. The analysis has shown insignificant differences in the values of the iodide peak area and its height measured in multicomponent mixtures with an error smaller than 5%.


Assuntos
Cromatografia Líquida de Alta Pressão , Iodetos/análise , Águas Minerais/análise , Fosfatidilcolinas/química , Ânions/química , Íons , Controle de Qualidade , Reprodutibilidade dos Testes
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