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1.
Science ; 367(6475): 257-258, 2020 01 17.
Artigo em Inglês | MEDLINE | ID: mdl-31949072
2.
Wien Klin Wochenschr ; 132(1-2): 47-49, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31912288

RESUMO

Leishmaniasis is a severe vector-borne disease with two main clinical forms, visceral leishmaniasis and cutaneous leishmaniasis. Both forms of leishmaniasis are also endemic in Mediterranean countries including the Balkan region from where mainly visceral leishmaniasis is reported. Austrian soldiers returning from Kosovo were screened for anti-Leishmania antibodies to assess the risk of infection during operations. Anti-Leishmania antibodies were detected in more than 20% of the soldiers investigated, which indicates a considerable risk of infection during missions in this area and thus suggests the application of protective measures.


Assuntos
Leishmania , Leishmaniose , Militares , Animais , Áustria , Humanos , Insetos Vetores , Kosovo , Leishmania/imunologia , Leishmaniose/diagnóstico , Leishmaniose/imunologia , Testes Sorológicos
3.
J Insect Sci ; 20(1)2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31925424

RESUMO

Urbanization has a significant impact on abiotic and biotic factors in nature. We examined the morphometric characters of four carabid species (Abax parallelepipedus, Carabus scheidleri, Carabus violaceus, and Pterostichus oblongopunctatus) along urbanization gradients in and around the cities of Vienna (Austria) and Debrecen (Hungary). We found significant differences among urban, suburban, and rural areas in the parameters of antennomers, the maxillary palpus, the labial palpus, and the length of the tibia and the elytra of the carabids studied. We also found significant differences between males and females based on the parameters of antennomers, the maxillary palpus, the labial palpus, the femur, and the elytra. An interaction between urbanization and sex was found in the case of antennomers, the maxillary palpus, the labial palpus, the femur, and the elytra. Our findings suggested that in the cases of species from Carabini tribus the parameters of antennomers, the maxillary palpus, and the elytra could be useful for assessing the effects of urbanization because these morphometric characters responded sensitively to the environmental stress, whereas the most useful parameters are those of antennomers and the tibia for the species of Pterostichini tribus. Our findings also revealed that females are more sensitive to environmental stress than males.


Assuntos
Besouros/anatomia & histologia , Urbanização , Animais , Áustria , Cidades , Feminino , Hungria , Masculino , Especificidade da Espécie
4.
J Surg Oncol ; 121(1): 91-99, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31650565

RESUMO

BACKGROUND: Lymphedema surgery was not widely known in Austria before the introduction of lymphovenous anastomosis (LVA) and vascularized lymph node transfer (VLNT) in 2014. This study shares the experience and process of establishing and institutionalizing lymphedema surgery service in Austria. METHODS: The purpose of introducing reconstructive lymphedema surgery in Austria was to improve lymphedema patients' quality of life and provide them surgical therapy as an adjuvant treatment to complete decongestive therapy. To initialize reconstructive lymphedema surgery in Austria, LVA and VLNT had to be presented and introduced, in the manner of branding and advertizing a new product. Surgeries were performed with quality control by standardized documentation, pre- and postoperatively. RESULTS: Aligned with branding and marketing, presentations were given externally and internally to share knowledge and experience of lymphedema surgery. Lymphedema surgery service was introduced as a new brand in the medical service in Austria. After several communications with the Austrian Health Insurance Fund and with the final application, LVA and VLNT were listed as novel surgical therapies in its 2020 reimbursement catalog. Since 2014, more than 300 lymphedema patients were consulted, and 102 reconstructive lymphedema surgeries were performed. Circumference reduction of extremities after surgery was between 20% and 43%, postoperatively. CONCLUSION: Acceptance of surgery in lymphedema patients varies among continents, hospitals, and surgeons. Evaluation of the requirement of the surgical setup and insurance conditions for lymphedema surgery is essential to establish lymphedema surgery, providing targeted marketing and branding to spread knowledge of the novel technique and grant patients access to therapeutic treatment of their chronic disease.


Assuntos
Cirurgia Geral/organização & administração , Linfedema/cirurgia , Adolescente , Adulto , Idoso , Anastomose Cirúrgica , Áustria , Criança , Feminino , Humanos , Linfonodos/transplante , Vasos Linfáticos/cirurgia , Linfedema/diagnóstico , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Procedimentos Cirúrgicos Reconstrutivos/métodos , Centro Cirúrgico Hospitalar , Adulto Jovem
5.
World Neurosurg ; 133: e583-e591, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31561040

RESUMO

OBJECTIVE: To assess the prognostic profile, clinical outcome, treatment-associated morbidity, and treatment burden of elderly patients with glioblastoma (GBM) undergoing microsurgical tumor resection as part of contemporary treatment algorithms. METHODS: We retrospectively identified patients with GBM ≥65 years of age who were treated by resection at 2 neuro-oncology centers. Survival was assessed by Kaplan-Meier analyses; log-rank tests identified prognostic factors. RESULTS: The study population included 160 patients (mean age, 73.1 ± 5.1 years), and the median contrast-enhancing tumor volume was 31.0 cm3. Biomarker analyses revealed O(6)-methylguanine-DNA methyltransferase-promoter methylation in 62.7% and wild-type isocitrate dehydrogenase in 97.5% of tumors. The median extent of resection (EOR) was 92.3%, surgical complications were noted in 10.0% of patients, and the median postoperative hospitalization period was 8 days. Most patients (60.0%) received adjuvant radio-/chemotherapy. The overall treatment-associated morbidity was 30.6%. The median progression-free and overall survival were 5.4 months (95% confidence interval [CI], 4.6-6.4 months) and 10.0 months (95% CI, 7.9-11.7 months). The strongest predictors for favorable outcome were patient age ≤73.0 years (P = 0.0083), preoperative Karnofsky Performance Status Scale score ≥80% (P = 0.0179), postoperative modified Rankin Scale score ≤1 (P < 0.0001), adjuvant treatment (P < 0.0001), and no treatment-associated morbidity (P = 0.0478). Increased EOR did not correlate with survival (P = 0.5046), but correlated significantly with treatment-associated morbidity (P = 0.0031). CONCLUSIONS: Clinical outcome for elderly patients with GBM remains limited. Nonetheless, the observed treatment-associated morbidity and treatment burden were moderate in the patients, and patient age and performance status remained the strongest predictors for survival. The risks and benefits of tumor resection in the age of biomarker-adjusted treatment concepts require further prospective evaluation.


Assuntos
Neoplasias Encefálicas/cirurgia , Glioblastoma/cirurgia , Procedimentos Neurocirúrgicos , Idoso , Idoso de 80 Anos ou mais , Áustria , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/patologia , Feminino , Glioblastoma/mortalidade , Glioblastoma/patologia , Humanos , Masculino , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
6.
J Environ Manage ; 253: 109756, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31677424

RESUMO

Biogas is mainly discussed in the context of renewable energy, digestate is playing a minor role. However, in the upcoming EU Fertilizer Product Regulation digestate as eligible component material is in line with the circular economy action plan. This article discusses the quality of raw digestate based on analysis data from Austrian biogas plants regarding to the current Austrian as well as the European fertilizer regulatory framework. Therefore, a survey among Austrian biogas plant operators for results of digestate analysis and substrate input and energy output is used. The results show, that the legislative framework applies to a minimum of 1.5 million tonnes of digestate. Austrian digestate is of high quality with regards to the nutrient content, required limit values for heavy metals and is also safe with respect to their hygienic parameters. The following European fertilizer product function categories are available for international trade of digestate: "organic soil improver", "growing medium", and "organic, non-microbial plant biostimulant". Establishing legal criteria determining End-of-Waste and subsequently the product status for digestate is another important step in the European circular economy.


Assuntos
Comércio , Fertilizantes , Agricultura , Anaerobiose , Áustria , Biocombustíveis , União Europeia , Internacionalidade
7.
Wien Klin Wochenschr ; 131(Suppl 6): 489-590, 2019 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-31792659

RESUMO

Elevated blood pressure remains a major cause of cardiovascular disease, disability, and premature death in Austria, with suboptimal rates of detection, treatment and control also in recent years. Management of hypertension is a common challenge for physicians with different spezializations. In an attempt to standardize diagnostic and therapeutic strategies and, ultimately, to increase the rate of patients with controlled blood pressure and to decrease the burden of cardiovascular disease, 13 Austrian medical societies reviewed the evidence regarding prevention, detection, workup, treatment and consequences of high blood pressure in general and in various clinical scenarios. The result is presented as the first national consensus on blood pressure. The authors and societies involved are convinced that a joint national effort is needed to decrease hypertension-related morbidity and mortality in our country.


Assuntos
Anti-Hipertensivos , Doenças Cardiovasculares , Hipertensão , Anti-Hipertensivos/uso terapêutico , Áustria , Pressão Sanguínea , Doenças Cardiovasculares/prevenção & controle , Consenso , Humanos , Hipertensão/complicações , Hipertensão/tratamento farmacológico
8.
Z Geburtshilfe Neonatol ; 223(6): 373-394, 2019 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-31801169

RESUMO

AIMS: This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of this guideline is to improve the prediction, prevention and management of preterm birth based on evidence obtained from recently published scientific literature, the experience of the members of the guideline commission and the views of self-help groups. METHODS: The members of the participating medical societies and organizations developed Recommendations and Statements based on the international literature. The Recommendations and Statements were adopted following a formal consensus process (structured consensus conference with neutral moderation, voting done in writing using the Delphi method to achieve consensus). RECOMMENDATIONS: Part 2 of this short version of the guideline presents Statements and Recommendations on the tertiary prevention of preterm birth and the management of preterm premature rupture of membranes.


Assuntos
Ruptura Prematura de Membranas Fetais , Trabalho de Parto Prematuro/prevenção & controle , Guias de Prática Clínica como Assunto , Nascimento Prematuro , Sociedades Médicas , Prevenção Terciária , Incompetência do Colo do Útero , Áustria , Feminino , Ruptura Prematura de Membranas Fetais/prevenção & controle , Ruptura Prematura de Membranas Fetais/terapia , Humanos , Recém-Nascido , Obstetrícia , Gravidez , Nascimento Prematuro/prevenção & controle , Nascimento Prematuro/terapia , Sistema de Registros
9.
Z Psychosom Med Psychother ; 65(4): 341-352, 2019 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-31801441

RESUMO

Objectives: Description of the qualifications of psychotherapy-training candidates in Austria at the beginning of their training. Methods: Psychotherapists in training in Austria were interviewed at the beginning of their training concerning their socio-demographic background and prior education. These background data were collected using the Trainee Background Information Form (TBIF), which was designed by the Society for Psychotherapy Research Interest Section on Therapist Training and Development (SPRISTAD). Results: The group of 197 psychotherapy trainees from Austria consists largely of women, of persons with high school education and with a satisfactory, financially secure life situation. One-third of them show a "second career" pattern, which is in line with the predominantly part-time training programs in Austria. A high percentage of the candidates have previous professional experience in the psychosocial field. Conclusions: As this is a pilot study, results can be seen as a starting point for further research in psychotherapy training and competence development. In discussing the findings, both national conditions and opportunities for future interdisciplinary research are considered.


Assuntos
Mão de Obra em Saúde/estatística & dados numéricos , Psicoterapia/educação , Psicoterapia/estatística & dados numéricos , Áustria , Demografia , Feminino , Humanos , Masculino , Projetos Piloto
10.
Zootaxa ; 4608(1): zootaxa.4608.1.13, 2019 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-31717170

RESUMO

As part of an ongoing phylogenetic study on the Neotropical Philonthina (Coleoptera: Staphylinidae) that includes species of Belonuchus Nordmann, 1837, Hesperus Fauvel, 1874 and Paederomimus Sharp, 1885 (Chani Posse Ramírez Salamanca in prep.), we examined type material of species belonging to these genera as well as conspecific material from different European and North American collections. Type and non-type material were either examined by MCP during a visit to the Natural History Museum, London, UK (BMNH) or borrowed from the following institutions: Field Museum of Natural History, Chicago, IL, USA (FMNH), Museum für Naturkunde der Humboldt-Universität, Berlin, Germany (ZMHB), Naturhistorisches Museum Wien, Vienna, Austria (NMW), Canadian National Collection of Insects, Ottawa, Canada (CNC) and Snow Entomological Collection, Natural History Museum/Biodiversity Research Center, University of Kansas, Lawrence, USA (SEMC). Based on our revision of relevant material from the abovementioned collections, two new synonyms are here proposed.


Assuntos
Besouros , Animais , Áustria , Berlim , Canadá , Alemanha , Londres , Filogenia
12.
Dis Aquat Organ ; 136(2): 193-197, 2019 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-31621652

RESUMO

Carp edema virus disease (CEVD), also known as koi sleepy disease (KSD), is an emerging viral disease caused by the carp edema virus (CEV). It is characterized by lethargic behavior, gill necrosis, and generalized edema, leading to significant morbidity and mortality in common carp and koi Cyprinus carpio. Accurate diagnosis of CEVD relies on amplification of a P4a protein-encoding DNA segment from the CEV genome. A phylogenetic analysis of amplified fragments revealed 3 distinct CEV genogroups: I, IIa, and IIb. We explored the phylogenetic relationship between Austrian CEV isolates with existing CEV genogroups. The phylogenetic analysis (n = 18) established the presence of the 3 extant CEV genogroups as well as 2 new CEV genogroups (IIIa and IIIb) classified to identify the Austrian isolates that were distinct from the existing CEV genogroups. It is evident that CEV infection cases are growing in number each year, which may be due to development of sensitive diagnostic assays, while information regarding the virus is scarce. National and international efforts are required to study the epidemiology of the CEV in major carp-producing countries.


Assuntos
Carpas , Doenças dos Peixes , Infecções por Poxviridae , Poxviridae , Animais , Áustria , Edema , Genótipo , Filogenia , Infecções por Poxviridae/veterinária
13.
Z Geburtshilfe Neonatol ; 223(5): 304-316, 2019 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-31623006

RESUMO

AIMS: This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of this guideline is to improve the prediction, prevention and management of preterm birth based on evidence obtained from recent scientific literature, the experience of the members of the guideline commission and the views of self-help groups. METHODS: Based on the international literature, the members of the participating medical societies and organizations developed Recommendations and Statements. These were adopted following a formal process (structured consensus conference with neutral moderation, voting was done in writing using the Delphi method to achieve consensus). RECOMMENDATIONS: Part I of this short version of the guideline lists Statements and Recommendations on the epidemiology, etiology, prediction and primary and secondary prevention of preterm birth.


Assuntos
Guias de Prática Clínica como Assunto , Nascimento Prematuro , Áustria , Feminino , Humanos , Recém-Nascido , Gravidez , Nascimento Prematuro/epidemiologia , Nascimento Prematuro/etiologia , Nascimento Prematuro/prevenção & controle , Prevenção Primária , Sistema de Registros , Prevenção Secundária , Sociedades Médicas
14.
Artigo em Inglês | MEDLINE | ID: mdl-31584863

RESUMO

In the period from 2007 to 2017 furan levels of foods were analysed by the Austrian Agency for Health and Food Safety. Based on these analytical data and the Austrian consumption data the dietary exposure of children and adults to furan was estimated by using a deterministic approach. For the adult population the mean and 95th percentile dietary exposures to furan were estimated at 0.31 µg/kg bodyweight per day and at 0.72 µg/kg bodyweight per day, respectively. The mean dietary exposure of children was estimated at 0.18 µg/kg bodyweight per day and is thus only about half as high as for Austrian adults. At the 95th percentile the dietary exposure of children was estimated at 0.49 µg/kg bodyweight per day. The main contributor to the total dietary exposure for adults is coffee followed by convenience products and for children the main contributors are grain products as well as convenience products, bread and snacks. Based on the BMDL10 of 0.064 mg/kg bodyweight per day for the development of cholangiofibrosis, the MOE-calculation revealed that the current levels of dietary exposure to furan are of concern for Austrian adult high consumers. The MOE-calculation, based on the BMDL10 of 1.31 mg/kg bodyweight per day for the development of hepatocellular adenomas, indicated a health concern for Austrian children and adults.


Assuntos
Exposição Dietética/análise , Contaminação de Alimentos/análise , Furanos/análise , Adulto , Áustria , Criança , Café/química , Grão Comestível/química , Humanos
15.
Wien Klin Wochenschr ; 131(19-20): 485-492, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31591676

RESUMO

BACKGROUND: Fumaric acid esters are recommended in European guidelines for induction and maintenance treatment of patients with moderate to severe plaque psoriasis. A systemic medication with pure dimethyl fumarate without monoethyl fumarate salts was recently licensed in Europe. OBJECTIVE: The efficacy and safety of pure dimethyl fumarate were assessed in patients with severe (physician global assessment) plaque psoriasis in Austria in the BRIDGE trial. METHODS: In this double blind, randomized, placebo-controlled trial patients received 16-week treatment with pure dimethyl fumarate in a head to head comparison with dimethyl fumarate with monoethyl fumarate salts, which is licensed in Germany. In this post hoc analysis the efficacy and safety were assessed in patients with severe psoriasis in Austria. RESULTS: Efficacy measures significantly improved in both active treatment arms compared to placebo in 65 patients after 16 weeks of treatment. Physician global assessment of clear/almost clear in the dimethyl fumarate group was non-inferior to the dimethyl fumarate with monoethyl fumarate salts group 2 months after end of treatment. No serious adverse reaction occurred in patients with dimethyl fumarate in contrast to the second active treatment. Efficacy outcome was paralleled by quality of life improvements. CONCLUSION: This is the first report of dimethyl fumarate in a severely affected population with plaque psoriasis. Dimethyl fumarate is effective and safe in the systemic treatment of adults with severe psoriasis (physician global assessment).


Assuntos
Fumarato de Dimetilo , Psoríase , Adulto , Idoso , Áustria , Fumarato de Dimetilo/efeitos adversos , Fumarato de Dimetilo/uso terapêutico , Método Duplo-Cego , Europa (Continente) , Feminino , Alemanha , Humanos , Masculino , Pessoa de Meia-Idade , Psoríase/tratamento farmacológico , Qualidade de Vida , Índice de Gravidade de Doença , Resultado do Tratamento , Adulto Jovem
16.
Anticancer Res ; 39(9): 4589-4596, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31519555

RESUMO

Despite recent advances in the treatment of gastric cancer, mortality related to this disease is still substantial. Surgery and chemotherapy represent the cornerstones of patient management. Targeted treatments that include anti-angiogenic agents and the advent of immunotherapies can contribute to improved patient prognosis. Herein, we present an Austrian consensus on the systemic treatment of patients with gastric adenocarcinoma and lower gastroesophageal junction, including those with human epidermal growth factor receptor 2 (HER2)-positive disease. The consensus considers the curative setting, as well as first-line to late-line systemic treatment options in the palliative setting. For HER2-positive disease, first-line and second-line therapies are discussed, as well as HER2 testing. Potential future therapies are also listed, with a focus on anti-angiogenic treatments and checkpoint inhibition, that might provide a further step forward in the management of patients with gastric cancer.


Assuntos
Adenocarcinoma/terapia , Algoritmos , Neoplasias Gástricas/terapia , Adenocarcinoma/diagnóstico , Adenocarcinoma/etiologia , Áustria , Terapia Combinada , Consenso , Gerenciamento Clínico , Humanos , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/etiologia
17.
Environ Pollut ; 255(Pt 1): 112975, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31541831

RESUMO

We analysed the total mercury (Hg) accumulation in bodies and gut contents of 13 species of marine wild fish, 7 species of wild freshwater fish and 4 species of farmed fish. In addition, metal concentrations were recorded in water, sediment, fish prey and fodder materials, to track the dynamics of bio-accumulation. Cultured freshwater fish were collected at four Austrian farms and compared with samples obtained from markets. Wild marine fish were collected at Santa Croce bank, in Italy (Mediterranean Sea). Metal accumulation varied with sampling site, species, and age (or weight) of fish. Wild marine fish exhibited higher levels than wild freshwater fish, which in turn had higher Hg levels than cultured freshwater fish. Mercury increased according to trophic levels of consumers. Total Hg contents in muscle of cultured and wild freshwater fish sampled in 2006-2008 did not exceed legal nutritional limits. Similarly, in market samples of trout and carp collected in 2019, we found low or undetectable concentrations of total Hg in muscle tissue. In contrast, some marine fish (both market samples and some species from coastal waters) exceeded the legal limits. Environmental contamination, food webs and biological factors are the main causes of Hg accumulation in fish. Our results reflect the actual differences between specific European sites and should not be generalized. However, they support the generally increasing demand for monitoring mercury pollution in view of its impact on human health and its value as an indicator of ecosystem contamination.


Assuntos
Monitoramento Ambiental/métodos , Peixes/metabolismo , Mercúrio/análise , Tanques/química , Água do Mar/química , Poluentes Químicos da Água/análise , Ração Animal/análise , Animais , Aquicultura , Áustria , Bioacumulação , Ecossistema , Peixes/crescimento & desenvolvimento , Cadeia Alimentar , Conteúdo Gastrointestinal/química , Humanos , Itália , Mar Mediterrâneo , Músculos/química
18.
Int J Syst Evol Microbiol ; 69(12): 3946-3954, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31535962

RESUMO

Three actinobacterial strains, 27D-LEPIT, 1B-Mac and 36A-HELLB, were isolated from small standing and running freshwater habitats located in Salzburg, Austria. Phylogenetic reconstructions based on 16S rRNA gene sequences and genome based on concatenated amino acid sequences of 119 single-copy genes referred the three strains within the family Microbacteriaceae to the genus Rhodoluna. The strains showed 100 % 16S rRNA gene sequence similarities to the previously described Candidatus Rhodoluna limnophila. Cells were very small, approximately 0.5×0.3 µm, and showed a red pigmentation in liquid nutrient broth-soyotone-yeast extract medium as well as on agar plates. The strains assimilated a broad variety of substrates; however, the patterns differed a great deal between the three investigated strains. For strain 27D-LEPIT, the major fatty acids were iso-C14 : 0 and anteiso-C15 : 0; the identified polar lipids were phosphatidylglycerol and diphosphatidylglycerol; the major respiratory quinone was MK-11; and analysis of the peptidoglycan structure indicated the presence of type B2ß (typeB10). The genomic DNA of the three strains was very small (1.4 Mbp) and had a DNA G+C content of 54 mol%. The investigated traits suggested that strains 36A-HELLB (=DSM 107805=JCM 32927), 1B-Mac (=DSM 107802=JCM 32925) and 27D-LEPIT (=JCM 32926T =DSM 107804T) represent a new species for which the name Rhodolunalimnophila sp. nov. is proposed, with strain 27D-LEPIT as the type strain.


Assuntos
Actinobacteria/classificação , Água Doce/microbiologia , Filogenia , Actinobacteria/isolamento & purificação , Áustria , Técnicas de Tipagem Bacteriana , Composição de Bases , DNA Bacteriano/genética , Ácidos Graxos/química , Tamanho do Genoma , Hibridização de Ácido Nucleico , Peptidoglicano/química , Fosfolipídeos/química , RNA Ribossômico 16S/genética , Análise de Sequência de DNA , Vitamina K 2/química
19.
Rev Esp Salud Publica ; 932019 Sep 20.
Artigo em Espanhol | MEDLINE | ID: mdl-31537778

RESUMO

BACKGROUND: In the scientific literature, the impacts of plateletpheresis on leukogram parameters are not clear, with a high divergence in the studies that have evaluated changes in leukocytes. The objective of this paper was to meta-analyze the effect of plateletpheresis on the leukocyte count, based on studies published between 1980-2018. METHODS: Systematic review with meta-analysis of random effects for the difference of means. The phases of the PRISMA guide were applied with 132 search strategies in Pubmed, Scielo, Science direct and Scopus. Reproducibility and evaluation of methodological quality were guaranteed. Heterogeneity was evaluated with Galbraith and Dersimonian and Laird's, publication bias with Funnel Plot and Begg; sensitivity analysis, accumulated meta-analysis and Forest Plot were carried out. RESULTS: Nineteen studies were included with 2,358 donors, mostly from India, United States, Turkey, Germany and Austria. A mean difference of -0,80 x109/L (IC95%= -1,96; 0,36x109/L) between the predonation value and the value immediately after donation was founded; no publication bias was found and the conclusion presented good sensitivity since it does not vary with the elimination of studies in successive phases. CONCLUSIONS: The donation of platelets by apheresis does not affect the leukocyte count in the donors, in the last century there were reports of reductions in this parameter, explained by the blood loss in the cases used for the procedure and by effects produced in the blood cells by the biomaterials; however, at present the high safety of plateletpheresis for the white blood cell count is evidenced.


Assuntos
Contagem de Células Sanguíneas , Leucócitos/citologia , Contagem de Plaquetas , Plaquetoferese/métodos , Áustria , Materiais Biocompatíveis , Doadores de Sangue , Alemanha , Humanos , Índia , Reprodutibilidade dos Testes , Espanha/epidemiologia , Turquia , Estados Unidos
20.
Artigo em Inglês | MEDLINE | ID: mdl-31546974

RESUMO

Noise legislation in Austria does not provide an assessment of the cumulative effect of noise from different sources. The desire of citizens for a total noise assessment is getting stronger. Within the pilot project "Gesamtlärmbetrachtung" (Total Noise Investigation) Innsbruck, data from 1031 face-to-face interviews were correlated with exposure data from road, rail and air traffic noise. The interviews were selected in clusters according to the exposure combinations of these three sources. In addition to exposure-response relationships, it has also been found that the annoyance response to air and rail traffic noise is independent of the background noise from road traffic. The total noise annoyance response shows a cumulative effect in each source considered. From the source specific exposure-response relationships, a total noise assessment model based on the annoyance equivalents model was developed. This model is more suitable than the dominant source model and thus also considerable for legal application.


Assuntos
Exposição Ambiental/efeitos adversos , Exposição Ambiental/estatística & dados numéricos , Ruído dos Transportes/efeitos adversos , Ruído dos Transportes/estatística & dados numéricos , Estresse Psicológico/etiologia , Adulto , Aeronaves , Animais , Áustria , Estudos Transversais , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Ruído , Projetos Piloto , Ferrovias
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