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1.
Food Chem Toxicol ; 135: 110940, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31693914

RESUMO

Eplingiella fruticosa (Lamiaceae), formally known as Hyptis fruticosa, is an important aromatic medicinal herb used in folk medicine in northeastern Brazil. We aimed to evaluate the anti-hyperalgesic effect of essential oil obtained from E. fruticosa (HypEO) complexed with ßCD (HypEO-ßCD) in a chronic widespread non-inflammatory muscle pain animal model (a mice fibromyalgia-like model, FM). The HypEO was extracted by hydro distillation and its chemical composition was determined by GC-MS/FID. Moreover, Fos protein expression in the spinal cord was assessed by immunofluorescence. (E)-caryophyllene, bicyclogermacrene, 1,8-cineole, α-pinene, ß-pinene and 21 other compounds were identified in the HypEO. The treatment with HypEO-ßCD produced a longer-lasting anti-hyperalgesic effect compared to HypEO, without alterations in motor coordination or myorelaxant effects. Moreover, HypEO and HypEO-ßCD produced a significant anti-hyperalgesic effect over 7 consecutive treatment days. Immunofluorescence assay demonstrated a decrease in Fos protein expression in the spinal cord (p < 0.001). We demonstrated that the anti-hyperalgesic effect produced by HypEO was improved after complexation with ß-CD and this seems to be related to the central pain-inhibitory pathway, suggesting the possible use of E. fruticosa for chronic pain management.


Assuntos
Analgésicos/uso terapêutico , Hiperalgesia/tratamento farmacológico , Lamiaceae/química , Mialgia/tratamento farmacológico , Óleos Voláteis/uso terapêutico , beta-Ciclodextrinas/uso terapêutico , Analgésicos/isolamento & purificação , Animais , Masculino , Camundongos , Óleos Voláteis/isolamento & purificação , Folhas de Planta/química , Proteínas Proto-Oncogênicas c-fos/metabolismo , Medula Espinal/efeitos dos fármacos , Medula Espinal/metabolismo
2.
Food Chem Toxicol ; 135: 110936, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31682933

RESUMO

Palygorskite (PGS) is a kind of clay minerals with the property of absorbent capacity, and ginger essential oil (GEO) is a kind of natural antibacterial substances. In the present study PGS was used as carrier of GEO, and thus, a kind of new anti-bacterial composite GEO-PGS has been obtained. Characterization, inhibitory effect of GEO-PGS on Escherichia coli (E. coli) and its function of improvement of intestinal health would be investigated. Results showed that characterization analysis of GEO-PGS (FTIR, TG-DSC, BET, Zeta potential, specific surface area, total pore volume and size, TEM observation) demonstrated combination of GEO and PGS, and GEO was absorbed on the surface of PGS, partially filled the micropores of PGS. GEO-PGS had obvious inhibitory effect on E.coli, in combination of the antibacterial activity of GEO and bacteria-absorbed capability of PGS. GEO-PGS also had ameliorating effect on enteritis and intestinal dysfunction in vivo, which might be related to the inhibition of gene expression of inflammatory cytokines (TLR2, IL-6, TNFα, and IL-8). In conclusion, the novel composite GEO-PGS has the potential usage as functional component having effect of improving intestinal health.


Assuntos
Antibacterianos/uso terapêutico , Enterite/tratamento farmacológico , Escherichia coli/efeitos dos fármacos , Gengibre/química , Compostos de Magnésio/uso terapêutico , Óleos Voláteis/uso terapêutico , Compostos de Silício/uso terapêutico , Animais , Citocinas/genética , Citocinas/metabolismo , Sinergismo Farmacológico , Enterite/microbiologia , Expressão Gênica/efeitos dos fármacos , Intestino Delgado/efeitos dos fármacos , Intestino Delgado/patologia , Camundongos , Testes de Sensibilidade Microbiana
3.
J Altern Complement Med ; 25(12): 1193-1199, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31556690

RESUMO

Objectives: The objective of this study was to determine if there was a significant difference between the sleep quality of patients who inhaled placebo and those who inhaled an aroma comprising a mixture of Lavandula x intermedia (Lavandin Super), Citrus bergamia (bergamot), and Cananga odorata (ylang ylang). Design: This was a randomized, double-blind crossover study, which compared a treatment with placebo. Settings/location: The study was conducted in an outpatient cardiac rehabilitation unit located in an urban, private nonprofit hospital in north Texas. Subjects: Participants included 42 adult patients referred to the rehabilitation service following hospitalizations by local cardiologists. Interventions: Cotton balls infused with a combination of lavender, bergamot, and ylang ylang or placebo were placed at subjects' bedsides for five nights. After a washout period, subjects crossed over to the other condition for five nights. Outcome measures: Participants completed the Pittsburgh Sleep Quality Index (PSQI) after treatment and placebo periods. Lower PSQI scores indicate better sleep quality. Results: The mean PSQI global score was statistically significantly lower when receiving the intervention oil (mean = 4.9) than the mean PSQI global score when receiving placebo (mean = 8). Duration of sleep and the time it took to fall asleep were no different between treatment groups, but patient-reported sleep quality was significantly better when participants were exposed to essential oils (χ2 = 4.5, p = 0.03) than when exposed to placebo. Although sleep efficiency (time asleep while lying in bed) was perceived as the same under both conditions, participants reported that they had to get up to use the bathroom significantly less often when exposed to the treatment than when exposed to placebo (t = -2.04, p = 0.05; Wilcoxon p = 0.05). Participants also reported that they had trouble sleeping because they felt too cold, which occurred significantly less often when exposed to the treatment than when exposed to placebo (t = -2.03, p = 0.05; Wilcoxon p = 0.05). Conclusions: Sleep quality of participants receiving intervention oils was significantly better than the sleep quality of participants receiving the placebo oil. Low-cost, nontraditional aromatherapy treatment is potentially effective for improving sleep quality among cardiac rehabilitation patients.


Assuntos
Reabilitação Cardíaca/métodos , Óleos Voláteis/uso terapêutico , Sono/efeitos dos fármacos , Idoso , Idoso de 80 Anos ou mais , Estudos Cross-Over , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Óleos Voláteis/farmacologia , Óleos Vegetais/farmacologia , Óleos Vegetais/uso terapêutico , Transtornos do Sono-Vigília/terapia
4.
Medicine (Baltimore) ; 98(36): e17009, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31490383

RESUMO

Erythrina corallodendron L., a kind of landscape tree, has long been used as a traditional medicine. In this study, the composition of essential oil extracted from the leaves was analysed by GC-MS (gas chromatograph-mass spectrometer), with linalool identified as the main compound. Its cytotoxicity against MDA-MB-231, MCF-7 and HMLE cells was examined by MTT and cloning assays. Transwell and wound-healing assays were used to examine the inhibition of migration and invasion. Western blot, qRT-PCR and immunofluorescence staining were used to measure the mRNA and protein expression of factors related to EMT (snail, slug, E-cadherin, N-cadherin and vimentin). The essential oil of Erythrina corallodendron leaves was found to inhibit the proliferation, migration and invasion of breast cancer cells in a dose-dependent manner. The findings of this study suggest that the essential oil of E. corallodendron leaves may merit further investigation as a potential clinical or adjuvant drug for treating breast cancer migration and invasion.


Assuntos
Adenocarcinoma/tratamento farmacológico , Antineoplásicos Fitogênicos/análise , Neoplasias da Mama/tratamento farmacológico , Erythrina/química , Óleos Voláteis/uso terapêutico , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Transição Epitelial-Mesenquimal/efeitos dos fármacos , Humanos , Células MCF-7 , Óleos Voláteis/química , Óleos Voláteis/isolamento & purificação , Óleos Voláteis/farmacologia , Fitoterapia , Folhas de Planta/química
5.
Eur J Oncol Nurs ; 42: 90-96, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31476706

RESUMO

PURPOSE: To examine the effects of the addition of lavender essential oil to the colostomy bag of the patients with permanent colostomy on the elimination of odor, quality of life, and ostomy adjustment. METHODS: As a parallel group, single-blinded randomized controlled trial with repeated measures, this study was conducted between November 2016 and February 2018. Patients with a permanent colostomy that had opened at least three months before the study were stratified according to age and sex and were randomized according to days of week. The study sample included 15 patients in the experimental group and 15 in the control group. Patients in the experimental group used lavender essential oil in the ostomy bag, and patients in the control group continued their routine practices about nutrition and stoma care for 1 month. RESULTS: There were no statistically significant differences in demographic characteristics between the experimental and control groups (p > 0.05). As compared with the control group patients, the experimental group patients who used lavender essential oil in the ostomy bag experienced statistically significant less odor, a higher quality of life, and better adjustment to ostomy (all p < 0.05). CONCLUSIONS: The use of lavender essential oil in the ostomy bag is a simple, low-cost, easy-to-use, and natural method that is effective for increasing both ostomy adjustment and quality of life levels and for eliminating odor in permanent colostomy patients.


Assuntos
Neoplasias Colorretais/terapia , Colostomia/psicologia , Ajustamento Emocional , Lavandula , Óleos Voláteis/uso terapêutico , Qualidade de Vida , Adulto , Idoso , Neoplasias Colorretais/psicologia , Colostomia/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Odorantes
6.
Complement Ther Clin Pract ; 36: 64-68, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31383445

RESUMO

BACKGROUND AND PURPOSE: Fatigue is a common complication of hemodialysis. This study aimed to compare the effects of aromatherapy with essential oils of lavender and orange on the fatigue of hemodialysis patients. MATERIALS AND METHODS: Ninety subjects were randomly allocated into three groups of aromatherapy with lavender essential oil, aromatherapy with orange essential oil and control. Data collection tool was the Fatigue Severity Scale. In each experimental group, subjects inhaled five drops of lavender essential oil and orange essential oil. RESULTS: The difference in the mean of fatigue before and after the intervention in each of the experimental groups was statistically significant, but this difference was not significant in the control group. Between the two groups of aromatherapy, no significant difference was observed in terms of the mean fatigue after the intervention. CONCLUSION: Aromatherapy with lavender essential oil and orange essential oil might reduce fatigue in hemodialysis patients.


Assuntos
Aromaterapia , Fadiga , Óleos Voláteis/uso terapêutico , Óleos Vegetais/uso terapêutico , Diálise Renal/efeitos adversos , Fadiga/etiologia , Fadiga/terapia , Humanos
7.
Arq. bras. med. vet. zootec. (Online) ; 71(4): 1251-1259, jul.-ago. 2019. tab, graf
Artigo em Português | LILACS, VETINDEX | ID: biblio-1038617

RESUMO

O objetivo deste estudo foi avaliar a atividade antimicrobiana in vitro do óleo essencial de Tagetes minuta L. contra Staphylococcus aureus e Escherichia coli e a citotoxicidade sobre células epiteliais da glândula mamária bovina (MAC-T), visando a seu uso no tratamento da mastite bovina. A análise qualitativa do óleo revelou cis-tagetona (24,24%), di-hidrotagetona (16,65%), 1,3,6-octatrieno-3,7-dimetil-E (13,61%), trans-ocimenona (13,52%) e cis-ocimenona (10,06%) como compostos majoritários. Nos ensaios da atividade antimicrobiana, a concentração inibitória mínima (CIM) verificada foi de 1 mg/mL para a cepa padrão (ATCC 25923), cinco isolados de S. aureus provenientes de leite de vacas com mastite e a cepa padrão resistente à meticilina (MRSA) (ATCC 33592). Para a cepa padrão de E. coli (ATCC 8739) e dois isolados de leite de vacas com mastite, a CIM foi de 3 mg/mL. Elevado efeito citóxico do óleo sobre as células da linhagem MAC-T foi constatado. Concentrações superiores a 10 (g/mL do óleo resultaram em mais de 90% de morte celular. Tais resultados sugerem que, apesar da atividade antimicrobiana contra agentes causadores da mastite bovina, a utilização intramamária do óleo de T. minuta não seria recomendada. É importante destacar a sensibilidade da cepa MRSA ao óleo essencial, o que evidencia seu potencial como antisséptico e sanitizante.(AU)


The aim of this study was to evaluate the in vitro antimicrobial activity of Tagetes minuta L. essential oil against Staphylococcus aureus and Escherichia coli, and its cytotoxicity to bovine mammary epithelial cells (MAC-T line), aiming at its use for bovine mastitis treatment. The qualitative analysis of the oil by GC-MS identified cis-tagetone (24.24%), dihydrotagetone (16.65%), 1,3,6-Octatriene 3,7-Dimethyl-E (13.61%); trans-ocimenone (13.52%) and cis-ocimenone (10.06%) as major compounds. Antimicrobial activity was determined by broth microdilution technique and revealed the minimum inhibitory concentration of 1mg/mL for the standard strain of S. aureus (ATCC 25923) and five bacterias isolated from mastitic milk, including a multiresistant strain (ATCC 33592); and 3mg/ml for the standard strain of E. coli (ATCC 8739) and two bacterias isolated from mastitic milk. However, a strong citotoxic effect on MAC-T cells was found. Oil concentrations from 10(g/mL resulted in over 90% of cell death. The results suggest that although the antimicrobial activity was identified against the main agents of bovine mastitis, the intramammary use of T. minuta oil may not be recommended. On the other hand, it is important to highlight the sensibility of the MSRA strain to the essential oil, which evidences its potential as an antiseptic or sanitizer.(AU)


Assuntos
Animais , Feminino , Bovinos , Óleos Voláteis/uso terapêutico , Tagetes , Mastite Bovina/prevenção & controle , Anti-Infecciosos/análise , Plantas Medicinais
8.
Complement Ther Med ; 45: 156-166, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31331554

RESUMO

PURPOSE: The objective of this study was to conduct a systematic review and meta-analysis to examine the effects of aromatherapy on sleep improvements. METHODS: A search of randomized controlled trials was conducted in four English and two Chinese medical electronic databases. Two authors independently performed the search, assessed the methodological quality, and extracted data. Then, final studies were selected after consensus with the third author. RESULTS: In total, 31 trials met the inclusion criteria, of which four had low risk, while the overall bias in 26 was uncertain in terms of methodological quality. The heterogeneity was high among the trials (Q = 341.544, p < 0.001, I2 = 91.216%). There was a significant effect of aromatherapy on sleep quality (Hedges's g = 1.103 (95% confidence interval: 0.813˜1.393, p < 0.001). There was a publication bias (Egger's regression intercept = 7.127, t = 3.055, p = 0.004 and Begg test, Kendall's tau with continuity correction, tau = 0.335 and Z = 2.651, p = 0.008). The subgroup analysis showed that there was a significant difference in the methodological quality among different studies (Q = 18.350, p <  0.001). Sensitivity analyses still revealed high heterogeneity after omitting one study at a time. CONCLUSIONS: The results showed that aromatherapy can be applied by clinical staff to effectively improve sleep quality. However, because there was a high degree of heterogeneity among studies, the inferences of the results need to be applied with caution.


Assuntos
Óleos Voláteis/uso terapêutico , Sono/efeitos dos fármacos , Sono/fisiologia , Animais , Aromaterapia/métodos , Humanos , Terapias Mente-Corpo/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto , Sensibilidade e Especificidade
9.
BMC Complement Altern Med ; 19(1): 174, 2019 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-31299970

RESUMO

BACKGROUND: The use of essential oils is growing in the United States, but clinician attitudes, experience, and beliefs regarding their use have not previously been studied. METHODS: One hundred five of 106 clinician attendees (99.1%) of an integrative medicine continuing education conference were surveyed using an audience response system to obtain baseline information. Response frequencies of each item were reported. Nonparametric correlations were assessed comparing the statement "In the last 12 months, I have used essential oils for myself and/or my family" with the other agree/disagree statements using Spearman's rho. RESULTS: A majority of participants personally used integrative medicine approaches other than aromatherapy (92.6%) and recommended them clinically (96.8%). Most had personally used essential oils (61%) and wished to offer essential oil recommendations or therapies to their patients (74.0%). Only 21.9% felt confident in their ability to counsel patients on safe use. Personal use of essential oils was highly correlated with confidence in the ability to counsel patients on safe use (Spearman coefficient 0.376, P = 0.000). CONCLUSIONS: This study indicates that clinicians interested in integrative medicine desire to provide aromatherapy recommendations, but do not feel confident in their ability to do so.


Assuntos
Aromaterapia , Medicina Integrativa/educação , Óleos Voláteis/uso terapêutico , Adulto , Idoso , Aromaterapia/tendências , Educação Médica Continuada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
10.
J Ethnopharmacol ; 242: 112060, 2019 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-31279865

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) is a plant traditionally used as medicine for anxiety symptoms. This activity was confirmed in preclinical studies. However, its efficacy was never studied in human clinical trials. AIM OF THE STUDY: We aimed to test the hypothesis that the herbal medicine of A. polystachya is superior to placebo for the treatment of anxiety-related symptoms in adults after 8 weeks. PATIENTS AND METHODS: This was a randomized, double-blind, placebo-controlled, phase-2 clinical trial. Fifty-four adults with self-reported anxiety symptoms were randomly allocated to receive either capsules containing A. polystachya powdered leaves (300 mg, twice a day) or placebo (maltodextrin), for 8 weeks. The intensity of anxiety symptoms was assessed by the Hamilton Anxiety Ranking Scale (HAM-A) at baseline and after 2, 4 and 8 weeks. All analyses were adjusted for physical activity (assessed by the International Physical Activity Questionnaire [IPAQ], short version) and gender. RESULTS: We confirmed the presence of acteoside (chromatographic analysis) and carvone and limonene (gas chromatography) as major constituents in our plant material. Only patients that received A. polystachya experienced a significant decrease in their HAM-A scores, with none or mild side-effects. CONCLUSION: Administration of powdered leaves of A. polystachya, rich in acteoside, carvone and limonene, to adults with anxiety symptoms was significantly superior to placebo in decreasing HAM-A scores after 8 weeks. This finding confirms the ethnopharmacological use of this plant for anxiety symptoms.


Assuntos
Ansiolíticos/uso terapêutico , Ansiedade/tratamento farmacológico , Preparações de Plantas/uso terapêutico , Verbenaceae , Adulto , Ansiolíticos/química , Cápsulas , Método Duplo-Cego , Feminino , Glucosídeos/análise , Glucosídeos/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Óleos Voláteis/análise , Óleos Voláteis/uso terapêutico , Fenóis/análise , Fenóis/uso terapêutico , Fitoterapia , Folhas de Planta/química , Preparações de Plantas/química , Pós
11.
Holist Nurs Pract ; 33(4): 222-229, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31192834

RESUMO

The aim of this study was to examine the effect of the application of lavender oil on fatigue and anxiety levels in patients undergoing hemodialysis treatment. This randomized controlled study was conducted with 60 patients (30 patients in intervention group, 30 patients in control group) in a province located in southeastern Turkey. After the patients in both groups were informed about the study, a questionnaire, the Fatigue Severity Scale, and the Beck Anxiety Inventory were applied to the patients. In the intervention group, a statistically significant difference was found between pretest and posttest scores of the Fatigue Severity Scale (t = 7.177, P = .001) and the Beck Anxiety Inventory (t = 10.371, P = .001). Mean scores of fatigue and anxiety decreased significantly following aromatherapy and also fatigue and anxiety levels declined. Lavender aromatherapy can be applied as an effective nursing intervention to reduce fatigue and anxiety of patients with chronic renal failure and undergoing hemodialysis treatment.


Assuntos
Ansiedade/terapia , Aromaterapia/normas , Fadiga/terapia , Diálise Renal/efeitos adversos , Adulto , Idoso , Ansiedade/etiologia , Ansiedade/psicologia , Aromaterapia/métodos , Fadiga/etiologia , Fadiga/psicologia , Feminino , Humanos , Falência Renal Crônica/psicologia , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Óleos Voláteis/administração & dosagem , Óleos Voláteis/uso terapêutico , Óleos Vegetais/administração & dosagem , Óleos Vegetais/uso terapêutico , Diálise Renal/psicologia , Inquéritos e Questionários , Turquia
12.
Chemotherapy ; 64(1): 1-7, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31234166

RESUMO

Infections with herpes simplex virus type (HSV)-1 and HSV-2 are distributed worldwide. Although standard therapies with acyclovir and other synthetic drugs are available, the safety and efficacy of these drugs are limited due to the development of drug resistance and adverse side effects. The literature on essential oils and isolated compounds was reviewed regarding their antiviral activities against HSV-1 and HSV-2. The present overview aims to review experimental data and clinical trials focusing on the antiviral activity of selected essential oils and isolated oil components. HSV was found to be susceptible to many essential oils and their constituents. Whereas some essential oils and compounds exhibit direct virucidal activity or inhibit intracellular replication, many essential oils and compounds interact with HSV particles thereby inhibiting cell adsorption. Ayclovir-resistant HSV strains are also susceptible to essential oils since their mode of action is different from the synthetic drug. There are numerous publications on the antiherpetic activity of essential oils and their isolated active compounds. This field of research is still growing, and more clinical trials are required to explore the full potential of different essential oils for the topical treatment of herpetic infections.


Assuntos
Herpes Simples/tratamento farmacológico , Óleos Voláteis/uso terapêutico , Antivirais/química , Antivirais/farmacologia , Antivirais/uso terapêutico , Adesão Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Ensaios Clínicos como Assunto , Humanos , Óleos Voláteis/química , Óleos Voláteis/farmacologia , Simplexvirus/efeitos dos fármacos , Simplexvirus/fisiologia
13.
J Altern Complement Med ; 25(8): 833-839, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31211612

RESUMO

Objective: This study evaluated the antianxiety effect of Citrus aurantium aroma (neroli oil) inhalation on patients with acute coronary syndrome (ACS). Design: A double-blind, placebo-controlled randomized trial. Setting/Location: This study was conducted in the Coronary Care Unit of Torfeh Hospital in Tehran, Iran, from September 2017 to February 2018. Subjects: A total of 140 hospitalized ACS patients (mean age = 56.72 ± 11.38 years) Interventions: Eligible patients were randomly assigned to citrus aroma and placebo groups to receive inhalation aromatherapy 2 days after hospitalization. Citrus aroma was 30% essential oil of Citrus aurantium L. flowers in paraffin, which was administrated three times a day. The placebo group received paraffin similarly. Outcome measures: The rate of anxiety was measured at baseline and after intervention using the State-Trait Anxiety Inventory. Results: At baseline, citrus aroma and placebo groups were similar in demographic characteristics as well as anxiety scores. After intervention, mean anxiety scores in the two groups become significantly different; the scores were 34.66 ± 9.6 and 42.36 ± 6.4 for citrus aroma and placebo groups, respectively (p < 0.0001). No side effect was observed. Conclusions: According to the current findings, aromatherapy with Citrus aurantium L. aroma (neroli oil) may be a safe and efficient intervention and can be considered an easy and applicable method to reduce anxiety in patients with ACS.


Assuntos
Síndrome Coronariana Aguda/complicações , Ansiedade , Aromaterapia/métodos , Citrus , Óleos Voláteis/uso terapêutico , Idoso , Ansiedade/etiologia , Ansiedade/terapia , Método Duplo-Cego , Feminino , Humanos , Masculino , Medicina Tradicional , Pessoa de Meia-Idade
14.
Drug Dev Ind Pharm ; 45(9): 1547-1555, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31216904

RESUMO

Chinese herbs such as Flos magnoliae (FM) and Centipeda minima (CM) can be effective in treating allergic rhinitis (AR). However, there is little research on the therapeutic mechanism of these two drugs acting on AR at the same time. In order to systematically understand the mechanism of action of two drugs acting on AR at the same time, we searched various databases to obtain 31 components and 289 target proteins of FM, 25 components and 465 target proteins of CM. The interaction networks of FM, CM, and AR proteins were constructed by Cytoscape-v3.2.1 software. The core protein of two network intersections was obtained by using Venny 2.1.0. The R platform was used for the core target protein gene ontology (GO) comment analysis and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis. Thirteen common targets and seven acting pathways were obtained. The results of animal experiments showed that FM and CM volatile oil could effectively improve the symptoms of AR by regulating the common targets. In summary, this study successfully explained the potential therapeutic mechanism of FM and CM in the treatment of AR. At the same time, it indicates that the two drugs can be compatible as a new application.


Assuntos
Asteraceae/química , Medicamentos de Ervas Chinesas/farmacologia , Magnoliaceae/química , Óleos Voláteis/farmacologia , Rinite Alérgica/tratamento farmacológico , Animais , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada/métodos , Medicamentos de Ervas Chinesas/uso terapêutico , Humanos , Masculino , Mucosa Nasal/efeitos dos fármacos , Mucosa Nasal/imunologia , Mucosa Nasal/patologia , Óleos Voláteis/uso terapêutico , Ovalbumina/administração & dosagem , Ovalbumina/imunologia , Mapas de Interação de Proteínas/efeitos dos fármacos , Mapas de Interação de Proteínas/imunologia , Ratos , Rinite Alérgica/diagnóstico , Rinite Alérgica/imunologia , Rinite Alérgica/patologia , Resultado do Tratamento
15.
Molecules ; 24(9)2019 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-31035694

RESUMO

The antispasmodic effect of drugs is used for the symptomatic treatment of cramping and discomfort affecting smooth muscles from the gastrointestinal, billiary or genitourinary tract in a variety of clinical situations.The existing synthetic antispasmodic drugs may cause a series of unpleasant side effects, and therefore the discovery of new molecules of natural origin is an important goal for the pharmaceutical industry. This review describes a series of recent studies investigating the antispasmodic effect of essential oils from 39 plant species belonging to 12 families. The pharmacological models used in the studies together with the mechanistic discussions and the chemical composition of the essential oils are also detailed. The data clearly demonstrate the antispasmodic effect of the essential oils from the aromatic plant species studied. Further research is needed in order to ascertain the therapeutic importance of these findings.


Assuntos
Óleos Voláteis/química , Óleos Voláteis/farmacologia , Parassimpatolíticos/química , Parassimpatolíticos/farmacologia , Animais , Bloqueadores dos Canais de Cálcio/química , Bloqueadores dos Canais de Cálcio/farmacologia , Canais de Cálcio/metabolismo , Estudos Clínicos como Assunto , AMP Cíclico/metabolismo , Avaliação Pré-Clínica de Medicamentos , Humanos , Estrutura Molecular , Contração Muscular/efeitos dos fármacos , Músculo Liso/efeitos dos fármacos , Músculo Liso/metabolismo , Óleos Voláteis/análise , Óleos Voláteis/uso terapêutico , Parassimpatolíticos/uso terapêutico , Compostos Fitoquímicos/química , Compostos Fitoquímicos/farmacologia , Extratos Vegetais/análise , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Relação Estrutura-Atividade , Resultado do Tratamento
16.
J Ethnopharmacol ; 238: 111887, 2019 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-31004726

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine (TCM) holds that deficiency of spleen-Qi is the major pathogenesis of chemotherapy-induced diarrhea (CID). Herb pair of Atractylodes macrocephala Koidz. (AM) and Panax ginseng C. A. Mey. (PG) has good effects of supplementing Qi and strengthening spleen. AIM OF THE STUDY: To investigate therapeutic effects and mechanism of Atractylodes macrocephala essential oil (AMO) and Panax ginseng total saponins (PGS) alone and in combination (AP) on 5-fluorouracil (5-FU) chemotherapy induced diarrhea in mice. MATERIALS AND METHODS: The mice were administered with AMO, PGS and AP respectively for 11 days, and intraperitoneally injected with 5-FU for 6 days since the 3rd day of the experiment. During the experiment, the body weights and diarrhea scores of mice were recorded daily. Thymus and spleen indexes were calculated after sacrifice of the mice. Pathological changes in ileum and colonic tissues were examined by hematoxylin-eosin (HE) staining. And the content levels of intestinal inflammatory cytokines were measured by enzyme-linked immmunosorbent assays (ELISA). 16S rDNA Amplicon Sequencing was used to analyze and interpret the gut microbiota of fecal samples. RESULTS: AP significantly inhibited body weights loss, diarrhea, reductions of thymus and spleen indexes, and pathological changes of ileums and colons induced by 5-FU. Neither AMO nor PGS alone significantly improved above-mentioned abnormalities. Besides, AP could significantly suppressed the 5-FU-mediated increases of the intestinal inflammatory cytokines (TNF-α, IFN-γ, IL-6, IL-1ß and IL-17), while AMO or PGS only inhibited some of them after 5-FU chemotherapy. Gut microbiota analysis indicated that 5-FU induced overall structural changes of gut microbiota were reversed after AP treatment. Additionally, AP significantly modulated the abundances of different phyla similar to normal values, and restored the ratios of Firmicutes/Bacteroidetes (F/B). At genus level, AP treatment dramatically decreased potential pathogens like Bacteroides, Ruminococcus, Anaerotruncus and Desulfovibrio. AP also antagonized the abnormal effects of AMO and PGS alone on certain genera like Blautia, Parabacteroides and Lactobacillus. Neither AMO nor PGS alone inhibited changes of gut microbial structure caused by 5-FU. CONCLUSIONS: AP, combination of AMO and PGS, not AMO or PGS alone, significantly ameliorated diarrhea, inhibited intestinal pathology, and modulated gut microbial structure in 5-FU induced mice. AP also antagonized abnormal effects of AMO or PGS on certain genera. The results illustrated that gut microbiota was involved in the combined effects of AP on 5-FU induced diarrhea.


Assuntos
Atractylodes/química , Diarreia/induzido quimicamente , Óleos Voláteis/uso terapêutico , Panax/química , Óleos Vegetais/uso terapêutico , Saponinas/uso terapêutico , Animais , Diarreia/tratamento farmacológico , Fluoruracila/toxicidade , Ginsenosídeos/química , Ginsenosídeos/uso terapêutico , Camundongos , Óleos Voláteis/química , Óleos Vegetais/química , Organismos Livres de Patógenos Específicos
17.
Medicina (Kaunas) ; 55(4)2019 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-30999703

RESUMO

Synergy is a process in which some substances cooperate to reach a combined effect that is greater than the sum of their separate effects. It can be considered a natural "straight" strategy which has evolved by nature to obtain more efficacy at low cost. In this regard, synergistic effects may be observed in the interaction between herbal products and conventional drugs or biochemical compounds. It is important to identify and exploit these interactions since any improvement brought by such kind of process can be advantageously used to treat human disorders. Even in a complex disease such as cancer, positive synergistic plant-drug interactions should be investigated to achieve the best outcomes, including providing a greater benefit to patients or avoiding adverse side effects. This review analyzes and summarizes the current knowledge on the synergistic effects of plant-drug interactions with a focus on anticancer strategies.


Assuntos
Antineoplásicos/uso terapêutico , Sinergismo Farmacológico , Interações Ervas-Drogas , Neoplasias/tratamento farmacológico , Compostos Fitoquímicos/uso terapêutico , Fitoterapia , Animais , Antagonismo de Drogas , Humanos , Camundongos , Óleos Voláteis/uso terapêutico , Polifenóis/uso terapêutico , Ratos
18.
Int J Med Mushrooms ; 21(3): 267-273, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31002610

RESUMO

A mixture of Laetiporus sulphureus (LS) and essential oils of Origanum vulgare, Cinnamomum verum, and Syzygium aromaticum (LOCS) was recommended for 24 patients with Crohn disease (CD). Patients were followed up for at least 24 months (median 32 months; range, 24-54 months). Nineteen patients were compliant with the treatment, although 3 stopped taking it, relapsed, began the LOCS regimen again, and recovered; 5 patients were not compliant at all. Compliant patients experienced flares of CD, with a CD Activity Index > 220, for 5.6% of the surveillance period (median 34 months). Noncompliant patients experienced flares of CD, with a CD Activity Index > 220, for 75.0% of the surveillance period (median 26 months; P < 10-6). Each case was then analyzed with a Bayesian approach that considered the probability of CD spontaneously disappearing within 2 weeks after intake of LOCS, the reappearance of CD within 2 weeks after stopping LOCS, and the disappearance of CD again after rechallenge. For the 19 compliant patients, the global posterior probability (probability that all the events observed were due to coincidence only) was equal to 10-6. Thus it can be concluded that LOCS decreases the CD Activity Index. Further investigations are necessary to unravel the mechanism of action of LOCS and to confirm its positive effect over periods as long as 5 to 10 years.


Assuntos
Agaricales/química , Produtos Biológicos/uso terapêutico , Doença de Crohn/tratamento farmacológico , Óleos Voláteis/uso terapêutico , Teorema de Bayes , Produtos Biológicos/química , Cinnamomum zeylanicum/química , Seguimentos , Humanos , Intestino Delgado/diagnóstico por imagem , Intestino Delgado/efeitos dos fármacos , Óleos Voláteis/química , Syzygium/química , Ultrassonografia
19.
Complement Ther Clin Pract ; 35: 177-182, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31003654

RESUMO

OBJECTIVE: The present study was conducted as a randomised controlled design in order to evaluate the effect of lavender oil inhalation on pain development during vascular access among patients undergoing haemodialysis. METHODS: The study was conducted involving a total of 60 patients receiving treatment at the haemodialysis unit of a public hospital. The data of study were collected using a questionnaire and a Visual Analogue Scale. Lavender oil inhalation containing a 1:10 ratio of lavender and sweet almond oil was prepared. RESULTS: The pain mean score of the intervention group was 3.8 ±â€¯0.3 prior to the application of lavender oil inhalation and decreased to 3.0 ±â€¯0.2 following the inhalation application; whereas, the pain mean score of the control group increased from 5.4 ±â€¯0.3 to 5.6 ±â€¯0.6. CONCLUSION: It was observed that applying lavender oil inhalation to patients undergoing haemodialysis did decrease pain level experienced by patients during vascular access and caused no negative effects.


Assuntos
Aromaterapia , Óleos Voláteis/uso terapêutico , Dor Processual/prevenção & controle , Óleos Vegetais/uso terapêutico , Diálise Renal/efeitos adversos , Administração por Inalação , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Dor Processual/diagnóstico , Dor Processual/etiologia , Resultado do Tratamento
20.
J Ethnopharmacol ; 239: 111916, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31034956

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Gynura procumbens is applied topically for the treatment of traumatic injuries in South China. MATERIALS AND METHODS: This study was conducted to identify the active ingredients in the essential oils from Gynura procumbens (GPEO) by Gas Chromatography-Mass Spectrometer (GC-MS) and to elucidate the mechanisms underlying the anti-inflammatory and antinociceptive effects in vivo and in vitro. RESULTS: A reduction in dswelling and pain were observed in mice treated with GPEO or its active ingredients (α-pinene, 3-carene, and limonene) compared with mice treated with a solvent control. GPEO or its three active ingredients had potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. All three ingredients inhibited nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, which could be responsible for the anti-inflammatory effect of GPEO. However, only 3-carene produced an antinociceptive effect. CONCLUSION: Consistent with the traditional usage in Southern China, GPEO may serve as a promising potent external therapeutic agent for the treatment of chronic pain.


Assuntos
Analgésicos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Asteraceae , Edema/tratamento farmacológico , Óleos Voláteis/uso terapêutico , Dor/tratamento farmacológico , Animais , Movimento Celular/efeitos dos fármacos , Edema/induzido quimicamente , Alimentos , Formaldeído , Temperatura Alta/efeitos adversos , Masculino , Medicina Tradicional Chinesa , Camundongos , Dor/induzido quimicamente , Fitoterapia , Células RAW 264.7
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