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2.
Expert Opin Drug Metab Toxicol ; 13(9): 925-934, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28772091

RESUMO

INTRODUCTION: When in flight, pilots of high performance aircraft experience conditions unique to their profession. Training flights, performed as often as several times a week, can expose these pilots to altitudes in excess of 15 km (~50,000 ft, with a cabin pressurized to an altitude of ~20,000 ft), and the maneuvers performed in flight can exacerbate the G-forces felt by the pilot. While the pilots specifically train to withstand these extreme conditions, the physiologic stress could very likely lead to differences in the disposition of chemicals in the body, and consequently, dangerously high exposures. Unfortunately, very little is known about how the conditions experienced by fighter pilots affects chemical disposition. Areas covered: The purpose of this review is to present information about the effects of high altitude, G-forces, and other conditions experienced by fighter pilots on chemical disposition. Using this information, the expected changes in chemical exposure will be discussed, using isopropyl alcohol as an example. Expert opinion: There is a severe lack of information concerning the effects of the fighter pilot environment on the pharmacokinetics and pharmacodynamics of chemicals. Given the possibility of exposure prior to or during flight, it is important that these potential effects be investigated further.


Assuntos
Altitude , Doenças Profissionais/fisiopatologia , Pilotos , 2-Propanol/envenenamento , Aeronaves , Animais , Gravitação , Humanos , Exposição Ocupacional/efeitos adversos , Estresse Fisiológico/fisiologia
3.
Clin Nephrol ; 88(10): 218-220, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28655383

RESUMO

Traditionally, ingestion of alcohol-based hand rub solution results in isopropanol poisoning, which has a low toxicity. We describe a case of combined methanol and isopropanol intoxication by ingestion of alcohol-based hand rub solution. Metabolic acidosis was absent in our patient, presumably because formic acid production is blocked by isopropanol, which inhibits alcohol dehydrogenase. Our case highlights the importance of considering methanol intoxication in patients who ingested alcohol-based hand rub solution, even when there is no metabolic acidosis, and timely removal of the toxic alcohols by dialysis in these patients would prevent permanent retinal damage.
.


Assuntos
2-Propanol/envenenamento , Intoxicação Alcoólica/terapia , Metanol/envenenamento , Diálise Renal/métodos , Adulto , Humanos , Masculino , Resultado do Tratamento
4.
Clin Toxicol (Phila) ; 55(3): 221-226, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28081653

RESUMO

BACKGROUND: Automotive screenwashes commonly contain ethylene glycol, methanol, and/or isopropanol; ethanol is also included in many formulations. The concentrations and combinations of each constituent vary considerably between the products. This study was undertaken to investigate the toxicity of automotive screenwashes as reported by telephone to the United Kingdom National Poisons Information Service (NPIS). METHODS: Enquiries to the NPIS relating to automotive screenwashes were analyzed retrospectively for the period January 2012 to December 2015. RESULTS: There were 295 enquiries involving 255 individual exposures. The majority (n = 241, 94.5%) of exposures involved ingestion and 14 of these also involved other routes. Six cases were due to skin contact alone, three to inhalation alone, three to eye contact alone, one to ear exposure alone and another occurred from inhalation and skin contact. Children below 5 years of age accounted for 26% of all ingestions. The identity (and therefore composition) of the screenwash was known with certainty in 124 of 241 ingestions and included methanol in 106 formulations, isopropanol in 72, ethylene glycol in 38, and ethanol in 104. The World Health Organisation/International Programme on Chemical Safety/European Commission/European Association of Poison Centres and Clinical Toxicologists Poisoning Severity Score was known in 235 of 241 cases of ingestion: most patients were asymptomatic (n = 169, 71.9%), but 59 (25.1%) developed minor (PSS 1), six (2.6%) moderate (PSS 2), and one patient severe (PSS 3) features; this patient later died. Nausea (n = 10), vomiting (n = 11), abdominal pain (n = 10), metabolic acidosis (n = 8) and raised anion gap (n = 8) were reported most commonly after ingestion. CONCLUSIONS: Most patients (71.9%) ingesting automotive screenwash did not develop features. The implication is that the amount of screenwash ingested was very small. Skin and eye exposure produced either no features or only minor toxicity.


Assuntos
2-Propanol/envenenamento , Etanol/envenenamento , Etilenoglicol/envenenamento , Metanol/envenenamento , Envenenamento/epidemiologia , 2-Propanol/química , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Etanol/química , Etilenoglicol/química , Humanos , Metanol/química , Pessoa de Meia-Idade , Centros de Controle de Intoxicações , Estudos Retrospectivos , Índice de Gravidade de Doença , Reino Unido/epidemiologia , Adulto Jovem
5.
Iran J Kidney Dis ; 10(6): 344-350, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27903992

RESUMO

The information on burden of alcohol abuse in Iran is scarce. However, the available data show that mortality rates and frequency of its use have increased in the Iranian community. In particular, Iran occupies the 1st rank in the number of outbreak incidents and victims of toxic alcohols such as methanol in the Middle East. Mortality and morbidity of toxic alcohols are high if prompt diagnosis and treatment are not initiated rapidly. On-time diagnosis, proper case finding, and standard treatment have an essential role to reduce mortality and morbidity of toxic alcohols particularly blindness and other physical and psychological disabilities. This review focuses on intoxication with methanol, ethylene glycol, and isopropanol, and their treatment.


Assuntos
Acidose/terapia , Antídotos/uso terapêutico , Etanol/uso terapêutico , Envenenamento/terapia , Pirazóis/uso terapêutico , Diálise Renal/métodos , Bicarbonato de Sódio/uso terapêutico , Solventes/envenenamento , 2-Propanol/metabolismo , 2-Propanol/envenenamento , Acidose/induzido quimicamente , Acidose/diagnóstico , Acidose/metabolismo , Alcoolismo/epidemiologia , Etilenoglicol/metabolismo , Etilenoglicol/envenenamento , Fomepizol , Humanos , Irã (Geográfico)/epidemiologia , Metanol/metabolismo , Metanol/envenenamento , Envenenamento/diagnóstico , Envenenamento/etiologia , Envenenamento/metabolismo , Solventes/metabolismo , Solventes/uso terapêutico
6.
Emerg Med Pract ; 18(9): 1-20, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27538060

RESUMO

Identifying patients with potential toxic alcohol exposure and initiating appropriate management is critical to avoid significant patient morbidity. Sources of toxic alcohol exposure include ethylene glycol, methanol, diethylene glycol, propylene glycol, and isopropanol. Treatment considerations include the antidotes fomepizole and ethanol, and hemodialysis for removal of the parent compound and its toxic metabolites. Additional interventions include adjunctive therapies that may improve acidosis and enhance clearance of the toxic alcohol or metabolites. This issue reviews common sources of alcohol exposure, basic mechanisms of toxicity, physical examination and laboratory findings that may guide rapid assessment and management, and indications for treatment.


Assuntos
Álcoois/envenenamento , Gerenciamento Clínico , Serviço Hospitalar de Emergência , Envenenamento/diagnóstico , Envenenamento/terapia , 2-Propanol/envenenamento , Acidose/induzido quimicamente , Acidose/diagnóstico , Acidose/terapia , Antídotos , Diagnóstico Diferencial , Etilenoglicol/envenenamento , Etilenoglicóis/envenenamento , Humanos , Metanol/envenenamento , Exame Físico , Propilenoglicol/envenenamento , Diálise Renal
7.
Int J Legal Med ; 130(4): 975-980, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26712504

RESUMO

A fatality of an inpatient ingesting a disinfectant containing ethanol, propan-1-ol, and propan-2-ol is reported. The alleged survival time was about 1 h. Major findings at autopsy were an extended hemorrhagic lung edema, an edematous brain, and shock kidneys. Concentrations of alcohols and acetone, a major metabolite of propan-2-ol, were determined from body fluids (blood from the heart and the femoral vein, urine, gastric contents) and tissues (brain, muscle, liver, kidneys, lungs) by headspace/gas chromatography using 2-methylpropan-2-ol as the internal standard. All samples investigated were positive for propan-1-ol, propan-2-ol, ethanol, and acetone except stomach contents, where acetone was not detectable. The low concentration of acetone compared to propan-2-ol likely supports the short survival time. The concentration ratios estimated from the results are in accordance with the physico-chemical properties of the particular alcohols, their different affinities towards alcohol dehydrogenase as well as their interdependence during biotransformation. Autopsy did not reveal the cause of death. According to the few published data, blood concentrations of 1.44 and 1.70 mg/g of propan-2-ol and propan-1-ol, respectively, are considered sufficient to have caused the death. This case also points to the need to restrict access to antiseptic solutions containing alcohols in wards with patients at risk.


Assuntos
1-Propanol/envenenamento , 2-Propanol/envenenamento , Desinfetantes/química , Desinfetantes/envenenamento , 1-Propanol/análise , 2-Propanol/análise , Acetona/análise , Transtorno da Personalidade Borderline/psicologia , Química Encefálica , Edema Encefálico/patologia , Etanol/análise , Etanol/envenenamento , Feminino , Conteúdo Gastrointestinal/química , Humanos , Rim/química , Rim/patologia , Fígado/química , Pulmão/química , Músculo Esquelético/química , Edema Pulmonar/patologia , Adulto Jovem
8.
Emerg Med Pract ; 18(9 Suppl Points & Pearls): S1-S2, 2016 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-28745842

RESUMO

Identifying patients with potential toxic alcohol exposure and initiating appropriate management is critical to avoid significant patient morbidity. Sources of toxic alcohol exposure include ethylene glycol, methanol, diethylene glycol, propylene glycol, and isopropanol. Treatment considerations include the antidotes fomepizole and ethanol, and hemodialysis for removal of the parent compound and its toxic metabolites. Additional interventions include adjunctive therapies that may improve acidosis and enhance clearance of the toxic alcohol or metabolites. This issue reviews common sources of alcohol exposure, basic mechanisms of toxicity, physical examination and laboratory findings that may guide rapid assessment and management, and indications for treatment. [Points & Pearls is a digest of Emergency Medicine Practice].


Assuntos
Alcoolismo/diagnóstico , Alcoolismo/fisiopatologia , 2-Propanol/efeitos adversos , 2-Propanol/envenenamento , Alcoolismo/epidemiologia , Antídotos/farmacologia , Antídotos/uso terapêutico , Diagnóstico Diferencial , Serviço Hospitalar de Emergência/organização & administração , Serviço Hospitalar de Emergência/estatística & dados numéricos , Etanol/farmacologia , Etanol/uso terapêutico , Etilenoglicol/efeitos adversos , Etilenoglicol/toxicidade , Etilenoglicóis/efeitos adversos , Etilenoglicóis/envenenamento , Fomepizol , Humanos , Metanol/efeitos adversos , Metanol/envenenamento , Propilenoglicol/efeitos adversos , Propilenoglicol/toxicidade , Pirazóis/farmacologia , Pirazóis/uso terapêutico , Diálise Renal/métodos
10.
Clin Toxicol (Phila) ; 52(5): 470-8, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24815348

RESUMO

INTRODUCTION: Isopropanol is a clear, colorless liquid with a fruity odor and a mild bitter taste. Most commonly found domestically as rubbing alcohol, isopropanol is also found in numerous household and commercial products including cleaners, disinfectants, antifreezes, cosmetics, solvents, inks, and pharmaceuticals. AIM: The aim of this review is to critically review the epidemiology, toxicokinetics, mechanisms of toxicity, clinical features, diagnosis, and management of isopropanol poisoning. METHODS: OVID MEDLINE and ISI Web of Science were searched to November 2013 using the words "isopropanol", "isopropyl alcohol", "2-propanol", "propan-2-ol", and "rubbing alcohol" combined with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", or "intoxication". These searches identified 232 citations, which were then screened via their abstract to identify relevant articles referring specifically to the epidemiology, toxicokinetics, mechanisms of toxicity, clinical features, diagnosis, and management of isopropanol poisoning; 102 were relevant. Further information was obtained from book chapters, relevant news reports, and internet resources. These additional searches produced eight non-duplicate relevant citations. EPIDEMIOLOGY: The majority of isopropanol exposures are unintentional and occur in children less than 6 years of age. Although isopropanol poisoning appears to be a reasonably common occurrence, deaths are rare. TOXICOKINETICS: Isopropanol is rapidly absorbed following ingestion with peak plasma concentrations occurring within 30 min. It can also be absorbed following inhalation or dermal exposure. Isopropanol is widely distributed with a volume of distribution of 0.45-0.55 L/kg. Isopropanol is metabolized by alcohol dehydrogenase to acetone, acetol and methylglyoxal, propylene glycol, acetate, and formate with conversion of these metabolites to glucose and other products of intermediary metabolism. The elimination of isopropanol is predominantly renal, though some pulmonary excretion of isopropanol and acetone occurs. In one case 20% of the absorbed dose was eliminated unchanged in urine, with the remainder excreted as acetone and metabolites of acetone. The elimination half-life of isopropanol is between 2.5 and 8.0 h, whereas elimination of acetone is slower with a half-life following isopropanol ingestion of between 7.7 and 27 h. MECHANISMS OF TOXICITY: While the exact mechanism of action of isopropanol has not been fully elucidated, brain stem depression is thought to be the predominant mechanism. While the clinical effects are thought to be mostly due to isopropanol, acetone may also contribute. CLINICAL FEATURES: The major features of severe poisoning are due to CNS and respiratory depression, shock, and circulatory collapse. The most common metabolic effects are an increased osmol (osmolal) gap, ketonemia, and ketonuria. Diagnosis. Poisoning can be diagnosed using the measurement of isopropanol serum concentrations, though these may not be readily available. Diagnosis is therefore more typically made on the basis of the patient's history and clinical presentation. An osmol gap, ketonemia, and/or ketonuria without metabolic acidosis, along with a fruity or sweet odor on the breath and CNS depression support the diagnosis. Management. Supportive care is the mainstay of management with primary emphasis on respiratory and cardiovascular support. Hemodialysis enhances elimination of isopropanol and acetone and should be considered in very severe poisoning. CONCLUSIONS: Severe isopropanol poisoning results in CNS and respiratory depression and circulatory collapse. Treatment primarily consists of symptom-directed supportive care. Although hemodialysis increases the elimination of isopropanol and acetone substantially, it should only be considered in severe life-threatening poisonings. Patients usually make a full recovery provided they receive prompt supportive care.


Assuntos
2-Propanol/envenenamento , Acetona/envenenamento , Solventes/envenenamento , 2-Propanol/farmacocinética , Animais , Criança , Pré-Escolar , Meia-Vida , Humanos , Diálise Renal/métodos , Solventes/farmacocinética , Distribuição Tecidual
11.
Przegl Lek ; 71(9): 479-83, 2014.
Artigo em Polonês | MEDLINE | ID: mdl-25632786

RESUMO

UNLABELLED: The purpose of the research was to present the analysis of acute alcohol poisonings (ethanol, methanol, ethylene glycol, isopropanol) in Toxicology Unit (TU), Nofer Institute of Occupational Medicine (NIOM), Lódz, Poland. MATERIALS AND METHODS: To further analysis were chosen all cases, whose were coded according to the International Statistical Classification of Diseases and Related Health Problems 10th Revision. RESULTS: There were 10,936 acute poisonings in the analyzed period of time 2007-2012 years, 3,088 of them referred to alcohol poisonings (28%). The largest group of patients included cases with ethanol intoxication (2,883 subjects), the second and third one-cases with methanol and ethylene glycol poisonings (99 and 98 respectively), 8 cases were poisoned with isopropanol. The largest group of patients includes cases at age less than 30 years. Patients at age above 60 years formed the lowest group among the total number of poisonings. Most of the admitted cases were men (2,417 patients) and cases hospitalized due to ethanol abuseladdiction (93%). Ethylene glycol poisonings constituted the leading cause of deaths (10 subjects). CONCLUSIONS: The study shows, that intoxications with alcohols are a big problem in NIOM and the number of alcohol poisonings markedly increased in the years 2007-2012.


Assuntos
Intoxicação Alcoólica/epidemiologia , Etanol/envenenamento , 2-Propanol/envenenamento , Adulto , Distribuição por Idade , Etilenoglicol/envenenamento , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Masculino , Metanol/envenenamento , Pessoa de Meia-Idade , Medicina do Trabalho/estatística & dados numéricos , Polônia/epidemiologia , Prevalência , Distribuição por Sexo
14.
J Forensic Sci ; 57(3): 674-8, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22268588

RESUMO

Isopropanol (IPA) detected in deaths because of diabetic ketoacidosis (DKA) or alcoholic ketoacidosis (AKA) may cause concern for IPA poisoning. This study addressed this concern in a 15-year retrospective review of 260 deaths in which concentrations of acetone and IPA, as well as their ratios, were compared in DKA (175 cases), AKA (79 cases), and IPA intoxication (six cases). The results demonstrated the frequency of detecting IPA in ketoacidosis when there was no evidence of IPA ingestion. IPA was detectable in 77% of DKA cases with quantifiable concentrations averaging 15.1 ± 13.0 mg/dL; 52% of AKA cases with quantifiable concentrations averaging 18.5 ± 22.1 mg/dL; and in cases of IPA intoxication, averaging 326 ± 260 mg/dL. There was weak correlation of IPA production with postmortem interval in DKA only (r = -0.48). Although IPA concentrations were much higher with ingestion, potentially toxic concentrations were achievable in DKA without known ingestion.


Assuntos
2-Propanol/sangue , Cetose/sangue , Cetose/diagnóstico , Mudanças Depois da Morte , 2-Propanol/envenenamento , Acetona/sangue , Biomarcadores/sangue , Depressores do Sistema Nervoso Central/sangue , Diagnóstico Diferencial , Etanol/sangue , Feminino , Ionização de Chama , Patologia Legal , Toxicologia Forense , Humanos , Masculino , Pessoa de Meia-Idade , Envenenamento/diagnóstico , Estudos Retrospectivos , Solventes/envenenamento
15.
Toxicol Lett ; 210(1): 44-52, 2012 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-22266471

RESUMO

Short-chain alcohols are embedded into several aspects of modern life. The societal costs emanating from the long history of use and abuse of the prototypical example of these molecules, ethanol, have stimulated considerable interest in its general toxicology. A much more modest picture exists for other short-chain alcohols, notably as regards their immunotoxicity. A large segment of the general population is potentially exposed to two of these alcohols, methanol and isopropanol. Their ubiquitous nature and their eventual use as ethanol surrogates are predictably associated to accidental or deliberate poisoning. This review addresses the immunological consequences of acute exposure to methanol and isopropanol. It first examines the general mechanisms of short-chain alcohol-induced biological dysregulation and then provides a tentative model to explain the molecular events that underlie the immunological dysfunction produced by methanol and isopropanol. The time-related context of serum alcohol concentrations in acute poisoning, as well as the clinical implications of their short-term immunotoxicity, is also discussed.


Assuntos
2-Propanol/toxicidade , Sistema Imunitário/efeitos dos fármacos , Metanol/toxicidade , 2-Propanol/farmacocinética , 2-Propanol/envenenamento , Citocinas/efeitos dos fármacos , Humanos , Imunidade Celular/efeitos dos fármacos , Imunidade Inata/efeitos dos fármacos , Metanol/farmacocinética , Metanol/envenenamento , Linfócitos T/efeitos dos fármacos
16.
Forensic Sci Med Pathol ; 8(1): 19-22, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21805374

RESUMO

The Armanni-Ebstein lesion is a histological change in the kidney consisting of sub-nuclear vacuolation of the proximal tubules. It has been most associated with diabetic ketoacidosis. The vacuoles have been reported to contain glycogen. More recent studies show them to contain fat. Recent papers have associated the Armanni-Ebstein lesion with non-diabetic ketoacidosis. We present 11 cases of alcoholic ketoacidosis where the Armanni-Ebstein lesion was identified. None had a history of diabetes mellitus and none showed any changes of diabetic nephropathy. All 11 cases had raised acetone levels (3-67 mg/100 mL (mean 17.9 mg/100 mL and median value of 16 mg/100 mL). In addition a case of isopropanol poisoning was found to have the Armanni-Ebstein lesion. Isopropanol is converted to acetone but is not associated with acidosis. These results indicate that the Armanni-Ebstein lesion is not specific to diabetes mellitus.


Assuntos
Alcoolismo/complicações , Cetose/etiologia , Cetose/patologia , Túbulos Renais Proximais/patologia , Vacúolos/patologia , 2-Propanol/envenenamento , Adulto , Idoso , Alcoolismo/patologia , Feminino , Patologia Legal , Humanos , Corpos Cetônicos/análise , Masculino , Pessoa de Meia-Idade , Solventes/envenenamento
17.
Am J Ther ; 18(4): e113-6, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20093926

RESUMO

Isopropyl ingestion is usually a benign occurrence with little metabolic or renal abnormalities. We describe a case of a false elevation of serum creatinine due to laboratory interference in the setting of a toxic alcohol exposure that could have led to a misdiagnosis of ethylene glycol intoxication and a different treatment plan. Clinicians should be aware of this laboratory anomaly when treating suspected toxic alcohol ingestions.


Assuntos
2-Propanol/envenenamento , Creatinina/sangue , Insuficiência Renal/diagnóstico , Idoso , Diagnóstico Diferencial , Etilenoglicol/envenenamento , Feminino , Humanos , Envenenamento/sangue , Envenenamento/diagnóstico , Insuficiência Renal/sangue , Insuficiência Renal/induzido quimicamente
18.
J Forensic Sci ; 55(4): 998-1002, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20384919

RESUMO

Isopropanol is an important chemical to forensic pathologists in that intoxication can result in death yet presence does not necessarily indicate intoxication. Several reports have been published, which indicate that isopropanol can be created endogenously in certain situations including diabetes mellitus, starvation, dehydration, and chronic ethanol use; however, a large-scale analysis addressing all of the possible causes of postmortem isopropanol detection has not been performed. A retrospective review of all cases examined at the Bexar County Medical Examiner's Office between 1993 and 2008 in which isopropanol was detected in routine alcohol screening was undertaken. The cases were categorized by the source of the isopropanol, and the concentrations of isopropanol and acetone were analyzed. Analysis revealed isopropanol concentrations to be low (<100 mg/dL) in cases of antemortem and postmortem creation and in postmortem contamination and high (>100 mg/dL) in cases of antemortem exposure. These results are consistent with other published reports.


Assuntos
2-Propanol/análise , 2-Propanol/metabolismo , Solventes/análise , Solventes/metabolismo , 2-Propanol/envenenamento , Acetona/análise , Acetona/metabolismo , Alcoolismo/metabolismo , Médicos Legistas , Desidratação/metabolismo , Diabetes Mellitus/metabolismo , Embalsamamento , Toxicologia Forense , Humanos , Desnutrição/metabolismo , Mudanças Depois da Morte , Solventes/envenenamento , Inanição/metabolismo , Coleta de Tecidos e Órgãos , Corpo Vítreo/química
19.
Am J Med Sci ; 339(3): 276-81, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20090509

RESUMO

In clinical practice, poisoning with ethylene glycol, methanol, and isopropyl alcohol is common. These alcohol-related intoxications can present with high anion gap metabolic acidosis and increased osmolality. Toxicity and clinical symptoms are due to the accumulation of their metabolites, causing increased anion gap, rather than the parent compounds that are associated with an increase of serum osmolality. Clinical manifestations result from abnormalities of neurologic, cardiopulmonary, and renal function. Laboratory abnormalities when present are helpful for diagnosis but may be absent depending on the time of ingestion and time of presentation. Fomepizole and ethanol are potent inhibitors of alcohol dehydrogenase and reduce generation of toxic metabolites. Hemodialysis is an effective way of detoxification because it can remove unmetabolized alcohol in addition to the organic anions. High index of suspicion and early diagnosis can prevent the significant morbidity and mortality associated with these intoxications.


Assuntos
2-Propanol/envenenamento , Etilenoglicol/envenenamento , Metanol/envenenamento , 2-Propanol/toxicidade , Animais , Etilenoglicol/toxicidade , Humanos , Metanol/toxicidade
20.
J Anal Toxicol ; 34(1): 49-52, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20109303

RESUMO

This paper presents the case of a woman with a history of schizophrenia found deceased in her residence after she apparently ingested an unknown quantity of a pine oil-containing product. A strong lemon-pine odor emanated from the body. Autopsy revealed a large volume of oily fluid in the stomach. The lungs were heavy, hemorrhagic, and necrotic. There was no evidence of significant recent injury or pre-existing disease. The toxicological screening and quantitation of 1-alpha-terpineol in postmortem fluids was performed by gas chromatography-mass spectrometry. Isopropanol and its metabolite acetone were determined by means of flame-ionization gas chromatography. Postmortem blood, urine, and stomach content levels of 1-alpha-terpineol were 276 mg/L, 0.5 mg/L, and 4.0 g/total contents, respectively, and isopropanol levels were 730 mg/dL, 20 mg/dL, and 1000 mg/dL, respectively. No acetone could be detected. Her death was attributed to the combined toxicity of isopropanol and pine oil.


Assuntos
2-Propanol/envenenamento , Produtos Domésticos/envenenamento , Pinus/química , Óleos Vegetais/envenenamento , 2-Propanol/farmacocinética , Cicloexenos/análise , Evolução Fatal , Feminino , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Pessoa de Meia-Idade , Monoterpenos/análise , Óleos Vegetais/farmacocinética , Suicídio
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