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1.
Adv Wound Care (New Rochelle) ; 12(2): 68-84, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35951024

RESUMO

Significance: Laser use has become part of the gold standard of treatment as an effective adjuvant in multimodal therapy for pathologic scarring caused by burns, trauma, acne, and surgery, as well as vascular anomalies. Understanding indications and applications for laser therapy is essential for physicians to improve patient outcomes. Recent Advances: Since the 1980s, the medical use of lasers has continuously evolved with improvements in technology. Novel lasers and fractionated technologies are currently being studied in the hopes to improve treatment efficacy, while reducing complications. Recent advancements include acne treatment with novel picosecond lasers, new hypertrophic scar therapies with simultaneous laser and intense pulsed light use, and novel systems such as lasers with intralesional optical fiber delivery devices. In addition, optimizing the timing of laser therapy and its use in multimodal treatments continue to advance the field of photothermolysis. Critical Issues: Selecting the correct laser for a given indication is the fundamental decision when choosing a laser balancing effective treatment with minimal complications. This article covers the principles of laser therapy, the preferred lasers used for the treatment of scarring and vascular anomalies, and discusses the current evidence behind these laser choices. Future Directions: To optimize laser therapy, larger randomized control trials and split scar studies are needed. Continued advancement through better randomized controlled studies will help to improve patient outcomes on a broader scale.


Assuntos
Acne Vulgar , Cicatriz Hipertrófica , Terapia a Laser , Terapia com Luz de Baixa Intensidade , Doenças Vasculares , Malformações Vasculares , Humanos , Cicatriz Hipertrófica/radioterapia , Cicatriz Hipertrófica/cirurgia , Acne Vulgar/complicações , Acne Vulgar/cirurgia , Resultado do Tratamento , Doenças Vasculares/complicações , Doenças Vasculares/cirurgia , Malformações Vasculares/cirurgia , Malformações Vasculares/complicações
4.
Front Immunol ; 13: 1029818, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36439142

RESUMO

This review presents several aspects of the innovative concept of sebaceous immunobiology, which summarizes the numerous activities of the sebaceous gland including its classical physiological and pathophysiological tasks, namely sebum production and the development of seborrhea and acne. Sebaceous lipids, which represent 90% of the skin surface lipids in adolescents and adults, are markedly involved in the skin barrier function and perifollicular and dermal innate immune processes, leading to inflammatory skin diseases. Innovative experimental techniques using stem cell and sebocyte models have clarified the roles of distinct stem cells in sebaceous gland physiology and sebocyte function control mechanisms. The sebaceous gland represents an integral part of the pilosebaceous unit and its status is connected to hair follicle morphogenesis. Interestingly, professional inflammatory cells contribute to sebocyte differentiation and homeostasis, whereas the regulation of sebaceous gland function by immune cells is antigen-independent. Inflammation is involved in the very earliest differentiation changes of the pilosebaceous unit in acne. Sebocytes behave as potent immune regulators, integrating into the innate immune responses of the skin. Expressing inflammatory mediators, sebocytes also contribute to the polarization of cutaneous T cells towards the Th17 phenotype. In addition, the immune response of the perifollicular infiltrate depends on factors produced by the sebaceous glands, mostly sebaceous lipids. Human sebocytes in vitro express functional pattern recognition receptors, which are likely to interact with bacteria in acne pathogenesis. Sex steroids, peroxisome proliferator-activated receptor ligands, neuropeptides, endocannabinoids and a selective apoptotic process contribute to a complex regulation of sebocyte-induced immunological reaction in numerous acquired and congenital skin diseases, including hair diseases and atopic dermatitis.


Assuntos
Acne Vulgar , Dermatite Atópica , Adulto , Adolescente , Humanos , Imunidade Inata , Homeostase , Dermatite Atópica/complicações , Lipídeos
5.
Dermatol Surg ; 48(12): 1306-1311, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36449872

RESUMO

BACKGROUND: Treatment with filler injections using a microneedle fractional radiofrequency (MFRF) device is a promising modality with proven efficacy for acne scar treatment. OBJECTIVE: To investigate the efficacy and histologic differences of intradermal injection of a filler (poly-d, l-lactic acid, PDLA) using an MFRF device for the treatment of acne scars. METHODS: Patients with acne scars on both cheeks were included. Poly-d, l-lactic acid was injected via the MFRF device every 4 weeks for a total of 4 sessions. Patients were evaluated using the grading system for acne scars before each session, as well as personal satisfaction. For histologic evaluation, 2 patients (who consented) underwent a skin biopsy from the upper arm before and after the same single session. RESULTS: After the final session, the acne scar grading (échelle d'évaluation clinique des cicatrices d'acné) scale and visual analog scale for evaluation of satisfaction showed improvement compared with initial assessment (36.99% and 79.65% respectively [p < .001, respectively]). For histologic evaluation, biodegradation of PDLA materials and increase in collagen and elastic fibers were observed after 5 months of treatment. CONCLUSION: Intradermal injection of PDLA using the MFRF device could be used as an effective treatment with fewer side effects in acne scar patients with Fitzpatrick skin type III-IV.


Assuntos
Acne Vulgar , Cicatriz , Humanos , Injeções Intradérmicas , Cicatriz/etiologia , Cicatriz/terapia , Estudos Prospectivos , Acne Vulgar/complicações , Ácido Láctico
7.
Rev Col Bras Cir ; 49: e20223369, 2022.
Artigo em Inglês, Português | MEDLINE | ID: mdl-36449943

RESUMO

Located in areas of difficult access, the riverside population of the upper Amazon River has a great demand for health care, whether in the scope of basic health promotion or in general or specialized medical care, surgical procedures, dental and pharmaceutical care. Taking this to consideration, the Barco Hospital Papa Francisco project was conceived and implemented, which aims to provide health care to riverside communities through expeditions that safely transfer health resources to populations located on the banks of the river. Having participated in one of the expeditions, it was possible to carry out a survey of data regarding the attendance and writing of a personal report on the impact on the professional activity. The expedition allowed the performance of a large number of surgical procedures in a condensed period, covering a wide variety of technical approaches essential to the performance of the general surgeon, among them, we can mention inguinal and incisional hernioplasties, umbilical and inguinal herniorrhaphy, postectomy and tubal ligation, lipoma excision, sebaceous cyst excision, nevi excision, among others (data available in the vessels Wareline® system).


Assuntos
Acne Vulgar , Expedições , Cirurgiões , Humanos , Rios , Hospitais
8.
J Microbiol Biotechnol ; 32(11): 1390-1395, 2022 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-36437519

RESUMO

Acne is a chronic inflammatory disease of the sebaceous gland attached to the hair follicles. Cutibacterium acnes is a major cause of inflammation caused by acne. It is well known that C. acnes secretes a lipolytic enzyme to break down lipids in sebum, and free fatty acids produced at this time accelerate the inflammatory reaction. There are several drugs used to treat acne; however, each one has various side effects. According to previous studies, sulforaphene (SFEN) has several functions associated with lipid metabolism, brain function, and antibacterial and anti-inflammatory activities. In this study, we examined the effects of SFEN on bacterial growth and inflammatory cytokine production induced by C. acnes. The results revealed that SFEN reduced the growth of C. acnes and inhibited proinflammatory cytokines in C. acnes-treated HaCaT keratinocytes through inhibiting NF-κB-related pathways. In addition, SFEN regulated the expression level of IL-1α, a representative pro-inflammatory cytokine expressed in co-cultured HaCaT keratinocytes and THP-1 monocytes induced by C. acnes. In conclusion, SFEN showed antibacterial activity against C. acnes and controlled the inflammatory response on keratinocytes and monocytes. This finding means that SFEN has potential as both a cosmetic material for acne prevention and a pharmaceutical material for acne treatment.


Assuntos
Acne Vulgar , Propionibacterium acnes , Humanos , Inflamação/tratamento farmacológico , Acne Vulgar/tratamento farmacológico , Acne Vulgar/microbiologia , Antibacterianos/metabolismo
9.
J Cosmet Laser Ther ; 24(6-8): 112-117, 2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36384385

RESUMO

A chemical peel is chemexfoliation, a process of application of a chemical substance to the skin that causes controlled chemical destruction of the epidermis with or without part of the dermis leading to skin regeneration and remodeling. It can be classified depending upon the depth of penetration into superficial, medium, and deep peels. Among various indications, peels can be used to enhance treatment within a variety of conditions including skin- rejuvenation, inflammatory disorders like acne, rosacea, acne scar, and pigmentary disorders like melasma, freckles, lentigens, dyschromia, and post-inflammatory pigmentation. We did a chemical peel for six patients with facial melanosis, diagnosed with Riehl melanosis. All patients had visible clinical improvement. Detailed history and informed consent were taken both for photographs and procedures from all patients.


Assuntos
Acne Vulgar , Abrasão Química , Dermatite de Contato , Melanose , Transtornos da Pigmentação , Humanos , Dermabrasão , Transtornos da Pigmentação/induzido quimicamente , Transtornos da Pigmentação/terapia
10.
J Cosmet Laser Ther ; 24(6-8): 103-106, 2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36403157

RESUMO

Acne scars lead to physical and psychological problems for young adults therefore they should be treated effectively. Fractional carbon dioxide (FCL) and radiofrequency (FRFL) lasers have been both used for acne scars. The aim of this study was to evaluate the effectivity and satisfaction of combined FCL and FRFL treatment for acne scars and evaluate effect of these treatments especially on atrophic scar types retrospectively. A total of 41 patients with acne scars who received FCL + FRFL were included in this study. Photographs of patients before treatment and 1 month following the last treatment session were scored by the other blinded clinician, according to the ECCA acne scar scoring method. A significant decrease was noted in clinical scores after the treatment. Side effects were minimal and acceptable. When comparing atrophic scars to erythematous ones laser treatment was more effective for atrophic types. In conclusion, our findings revealed that laser treatment with FCL + FRFL for acne scars is successful, effective and comfortable. These combination is more effective in atrophic type acne scars.


Assuntos
Acne Vulgar , Cicatriz , Adulto Jovem , Humanos , Cicatriz/etiologia , Cicatriz/radioterapia , Estudos Retrospectivos , Lasers , Agulhas , Atrofia , Acne Vulgar/complicações , Acne Vulgar/radioterapia
11.
Dermatol Surg ; 48(11): 1203-1209, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36342251

RESUMO

BACKGROUND: Combination of microneedling and chemical peeling is a simple cost-effective treatment for acne scars. OBJECTIVE: To compare efficacy and safety of combining microneedling with 35% glycolic acid (GA) peel versus microneedling with 15% trichloroacetic acid (TCA) peel in facial atrophic acne scars. METHODS: Forty acne scars patients were randomly divided into 2 groups of 20 each. Patients underwent microneedling followed by 35% GA peeling in Group 1 and 15% TCA peeling in Group 2 at 2 weekly intervals. Improvement was graded by Goodman and Baron's qualitative and quantitative global acne scar grading systems, physician's global assessment, and visual analogue scale (VAS). Skin texture was graded by VAS. RESULTS: On comparing qualitative and quantitative acne scar grading within groups, there was significant difference from the baseline. When the two groups were compared for quantitative and qualitative acne scar grading, the difference was statistically not significant at the end of therapy. In VAS, greater number of patients assessed response as excellent and good in Group 1 than in Group 2 indicating better skin texture improvement in Group 1. CONCLUSION: Both combinations were equally efficacious in treating acne scars. Glycolic acid peel delivered additional advantage of improvement in skin texture.


Assuntos
Acne Vulgar , Doenças do Tecido Conjuntivo , Humanos , Cicatriz/etiologia , Cicatriz/terapia , Cicatriz/patologia , Ácido Tricloroacético/efeitos adversos , Agulhas , Acne Vulgar/complicações , Acne Vulgar/terapia , Atrofia , Resultado do Tratamento
12.
J Drugs Dermatol ; 21(11): 1191-1195, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36342733

RESUMO

The associated direct and indirect costs of acquiring acne vulgaris (acne) treatment from a clinician may prohibit some patients from doing so. Barriers to care may also influence patient preferences for treatment, and while both over-the-counter (OTC) and prescription acne treatments are efficacious, preferences for OTC or prescription acne medications are not well established. We recruited 529 adult subjects from the United States through Amazon Mechanical Turk (MTurk), and subjects were surveyed about acne, their acne treatment preferences, and any barriers to care. A total of 450 subjects passed the attention check and were included in the analysis. Of respondents who had tried both OTC and prescription treatments (n=223), more respondents reported that they preferred prescription treatments (130/223, 58.3%), compared with OTC treatments (64/223, 28.7%); or no preference (29/223, 13.0%; P=0.00001). Almost half of all respondents also stated that they experienced barriers to accessing medical care for acne treatment (192/450 42.7%); cost and transportation were the top 2 factors. Considering how common barriers are, and their everchanging nature, some patients may benefit from a discussion of alternative non-prescription acne treatments, serving as a bridge to therapy or while patients are unable to reach a medical provider. J Drugs Dermatol. 2022;21(11):1191-1195. doi:10.36849/JDD.6940.


Assuntos
Acne Vulgar , Medicamentos sob Prescrição , Adulto , Humanos , Estados Unidos , Preferência do Paciente , Acne Vulgar/diagnóstico , Acne Vulgar/tratamento farmacológico , Medicamentos sem Prescrição/uso terapêutico , Inquéritos e Questionários , Acesso aos Serviços de Saúde , Resultado do Tratamento
13.
J Drugs Dermatol ; 21(11): 1173-1180, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36342736

RESUMO

BACKGROUND: Gentle skin cleansing and exfoliation and the use of moisturizers as an adjunct to medical treatment should be part of the prevention, treatment, and maintenance of cutaneous conditions such as acne vulgaris (acne) psoriasis, and xerosis. A monofilament fiber debriding technology (MFDT) is used for effective, safe, and rapid skin cleansing and exfoliation and debris, slough, and biofilm removal. The current review addresses the clinical experience using MFDT for various cutaneous conditions that require cleansing or exfoliation or both and how to combine it with medical treatment. METHODS: A literature review explored clinical insights into the role of skin cleansing and exfoliation for patients with various dermatological conditions. The searches yielded 29 publications, 7 guidelines/algorithms, 13 reviews, 8 clinical studies, and one in vitro study. RESULTS: Mechanical cleansing using a device can be helpful; however, avoid injury of the skin as it may result in thickening of the epidermis leading to hyperkeratosis and disruption of the skin barrier. Clinical experience with MFDT for acne, psoriasis, atopic dermatitis, and xerosis is discussed. Additionally, MFDT was used to exfoliate hyperkeratosis, actinic keratosis, and traumatic skin tattoos. CONCLUSIONS: Mechanical cleansing using MFDT was shown to be safe and beneficial for skin cleansing and exfoliation of various cutaneous conditions; however, only anecdotal evidence or small studies are available to support its use for these conditions. J Drugs Dermatol. 2022;21(11):1173-1180. doi:10.36849/JDD.6261.


Assuntos
Acne Vulgar , Dermatite Atópica , Psoríase , Humanos , Acne Vulgar/tratamento farmacológico , Dermatite Atópica/tratamento farmacológico , Epiderme , Tecnologia , Psoríase/diagnóstico , Psoríase/tratamento farmacológico
14.
J Drugs Dermatol ; 21(11): s13223-s132214, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36342741

RESUMO

BACKGROUND: Racial/ethnic differences in the clinical presentation, sequelae, and desired treatment outcomes for acne have been reported. Post-inflammatory hyperpigmentation (PIH) frequently occurs in patients with richly pigmented skin complexions and can frequently be the most bothersome aspect of acne in this population. METHODS: The project used a modified Delphi hybrid process comprising face-to-face discussions followed by an online follow-up. A structured literature search was conducted to identify publications on racial/ethnic differences in the clinical presentation, sequelae, and desired treatment outcomes for skin of color (SOC) patients with acne . The advisors subsequently convened to review the results and draft an algorithm for the treatment and maintenance, including skincare recommendations, for SOC patients with acne. Online, the panel reviewed and adopted the algorithm using published evidence coupled with the panel's expert opinion and clinical experience. RESULTS: Studies suggest that strategies for improving outcomes in patients with acne who have SOC include: the early initiation and maintenance of treatment regimens; careful consideration of the tolerability of active ingredients, vehicle formulations, and dosing; and the use of skin care (eg, pH balanced, non-irritating cleansers, and non-comedogenic moisturizers) to minimize irritation or dryness. CONCLUSION: Acne treatment in patients with SOC involves unique therapeutic considerations, including management of PIH through efficacious longitudinal acne treatment, prevention of irritation, and potential active treatment of PIH. Skincare products are recommended as an adjunct to prescription therapy to maximize tolerability and may also play a role in maintenance therapy. J Drugs Dermatol. 2022;21:11(Suppl 2):s3-14.


Assuntos
Acne Vulgar , Hiperpigmentação , Humanos , Pigmentação da Pele , Índice de Gravidade de Doença , Acne Vulgar/tratamento farmacológico , Acne Vulgar/complicações , Higiene da Pele , Hiperpigmentação/complicações , Algoritmos
15.
Medicina (Kaunas) ; 58(11)2022 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-36422207

RESUMO

Carbon peel laser treatment has been described for the improvement of skin texture, with pore reduction and acne lesion treatment. The technique consists of applying a carbon mask to the face for about ten minutes followed by laser irradiation with a Q-switched 1064 nm laser. This mechanism of action seems to be related to small carbon molecules binding both the corneocytes and serum within the hair follicles; the effect of the laser eliminates carbon bound to skin particles and the high temperature generated reduces sebum production by sebaceous glands and inhibits Cutibacterium acnes replication. Although this method was described 20 years ago, scientific data supporting its efficacy and safety have only recently been reported in small case series. For this reason, we performed a retrospective study including patients treated from January to May 2022 in the context of a private practice. Even if this study is limited by the low number of patients and its retrospective nature, this is the first research to show that carbon peel laser, performed with a standardized technique, is an effective and safe treatment for patients with acne lesions, showing pores and wrinkles, and is able to improve the overall skin aspect.


Assuntos
Acne Vulgar , Carbono , Humanos , Estudos Retrospectivos , Carbono/uso terapêutico , Acne Vulgar/radioterapia , Pele/patologia , Lasers
16.
Medicina (Kaunas) ; 58(11)2022 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-36363566

RESUMO

Background and Objectives: Acne vulgaris is one of the most common dermatological disorders among adolescents and adults in the Kingdom of Saudi Arabia (KSA). Isotretinoin is a cost-effective way of treating severe acne patients compared to other methods used for severe forms of acne management. The present study investigated the knowledge of the use of isotretinoin and its side effects among female acne patients of the reproductive age group who were on isotretinoin. This study also assessed participants' awareness of the Saudi FDA-Pregnancy Prevention Program (SFDA-PPP). Materials and Methods: The present population-based cross-sectional survey was conducted among 768 participants using a standard and validated Arabic version questionnaire. We have applied logistic regression analysis to determine the predictors for awareness of SFDA-PPP. A Chi-square test was applied to identify the factors associated with knowledge related to isotretinoin. Results: Regarding the side effects of isotretinoin, participated female acne patients were most commonly aware of dry mouth and lips (84.5%), teratogenicity (68.2%), and headache (44.8%). Nearly 60% of the participants belonged to the low knowledge category. The present study participants' knowledge was significantly associated with education status (p = 0.007), occupation (p = 0.01), and those participants who were aware of SFDA-PPP (p = 0.001). Furthermore, we explored that only 37.5% were aware of the SFDA-PPP program implemented in Saudi Arabia. The awareness of SFDA-PPP was significantly higher among those participants belonging to health sectors (Adjusted OR (95% CI) = 1.39 (1.01-1.92), p = 0.049). Conclusion: The present survey explored inadequate knowledge among reproductive age group female acne patients regarding isotretinoin uses, precautions to be followed, and side effects, especially teratogenic effects. This survey findings suggest that improving female acne patients' knowledge of isotretinoin through health promotion activities is crucial, especially by giving them precise instructions about the teratogenic effects.


Assuntos
Acne Vulgar , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Adulto , Adolescente , Gravidez , Humanos , Feminino , Isotretinoína/efeitos adversos , Estudos Transversais , Arábia Saudita , Acne Vulgar/tratamento farmacológico , Inquéritos e Questionários
17.
Skin Res Technol ; 28(6): 865-871, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36321243

RESUMO

OBJECTIVE: The scar's appearance and psychological burden are the most esthetically challenging issues in acne vulgaris. This study investigated the effectiveness and safety profile of combined radiofrequency-assisted subcision, which, even though effective on both Icepeak and Rolling subtypes, is only mildly effective on boxcar lesions, and polycaprolactone-based dermal filler with collagen stimulation potency in managing atrophic postacne scars. METHODS: Our quasi-experimental single-arm study, after the inclusion of 10 cases over the age of 18 with moderate to severe mixed atrophic facial acne scarring, was carried out in two 3-month separate sessions, during and after the intended intervention of which the experienced lesion improvements and also adverse events were documented. Moreover, all cases were followed for 3 months after the last session, evaluating the differences in the mentioned outcomes. RESULTS: We found the combined intervention to be highly effective in improving the intended outcomes, with the total number of acne lesions (p-value < 0.001), along with the total number of Ice peak (p-value = 0.002), Rolling (p-value < 0.001), and boxcar (p-value = 0.023) lesions demonstrating statistically significant changes. CONCLUSION: Radiofrequency-assisted subcision combined with polycaprolactone-based dermal fillers can be an effective intervention in managing postacne scars. However, we recommend that randomized clinical trials with larger sample sizes be carried out for a more precise conclusion.


Assuntos
Acne Vulgar , Preenchedores Dérmicos , Humanos , Adulto , Pessoa de Meia-Idade , Cicatriz/etiologia , Cicatriz/terapia , Cicatriz/patologia , Resultado do Tratamento , Acne Vulgar/complicações , Acne Vulgar/terapia , Atrofia
18.
Sci Rep ; 12(1): 19217, 2022 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-36357775

RESUMO

Bacillus circulans (B. circulans) is widely used as an electrogenic bacterium in microbial fuel cell (MFC) technology. This study evaluated whether B. circulans can ferment glucose to generate electricity and mitigate the effects of human skin pathogens. The electricity production of B. circulans was examined by measuring the voltage difference and verified using a ferrozine assay in vitro. To investigate the fermentation effects of B. circulans on inhibition of human skin pathogens, Cutibacterium acnes (C. acnes) was injected intradermally into mice ears to induce an inflammatory response. The results revealed that the glucose-B. circulans co-culture enhanced electricity production and significantly supressed C. acnes growth. The addition of roseoflavin to inhibit flavin production considerably reduced the electrical energy generated by B. circulans through metabolism and, in vivo test, recovered C. acnes count and macrophage inflammatory protein 2 (MIP-2) levels. This suggests that B. circulans can generate electrons that affect the growth of C. acnes through flavin-mediated electron transfer and alleviate the resultant inflammatory response. Our findings demonstrate that probiotics separated from natural substances and antimicrobial methods of generating electrical energy through carbon source fermentation can help in the treatment of bacterial infections.


Assuntos
Acne Vulgar , Mel , Probióticos , Camundongos , Animais , Humanos , Elétrons , Acne Vulgar/terapia , Acne Vulgar/microbiologia , Propionibacterium acnes , Probióticos/farmacologia , Flavinas , Glucose/farmacologia
19.
Dermatol Ther ; 35(10): e15753, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36190007

RESUMO

The medical face mask, widely used by health care providers (HCPs) during the COVID-19 pandemic, is reported to be associated with adverse reactions, among which acne is one of the most common. This study aims to evaluate treatment strategies employed by HCPs affected by acne in association with prolonged medical face mask use, their openness towards accessing telemedicine as a patient, and other lifestyle factors with potential influence on the evolution of their acne. Our online-based cross-sectional survey was distributed between December 17, 2020, and February 17, 2021, and targeted HCPs from different medical centers in Romania. From the n = 134 respondents, 50% reported current acne lesions and 56.7% required treatment. Of the latter, 65.8% self-medicated and 34.2% sought medical advice. The most common treatment associations between anti-acne topical products were: retinoids and salicylic acid (18.18%; n = 8), retinoids and benzoyl peroxide (13.64%; n = 6), salicylic acid and benzoyl peroxide (13.64%; n = 6), and azelaic acid together with salicylic acid (9.09%; n = 4). The health care provider responders were reluctant to use telemedicine, as only 14.2% participants were open to telemedicine. Our results suggest inadequate management of acne in HCPs using medical face masks. As with other occupational hazards and proper usage of personal protective equipment, HCPs should receive adequate screening, training, and treatment for this condition.


Assuntos
Acne Vulgar , COVID-19 , Fármacos Dermatológicos , Acne Vulgar/induzido quimicamente , Acne Vulgar/epidemiologia , Acne Vulgar/terapia , Antibacterianos , Peróxido de Benzoíla , COVID-19/epidemiologia , Estudos Transversais , Pessoal de Saúde , Humanos , Pandemias , Retinoides , Ácido Salicílico/uso terapêutico
20.
Lasers Med Sci ; 37(9): 3639-3647, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36197599

RESUMO

Selective photothermolysis of the sebaceous glands has the potential to be an effective alternative for treating acne vulgaris. However, the translation of this technique to clinical settings has been hindered by a lack of appropriate energy sources to target sebaceous glands, concerns surrounding safety, and treatment-related discomfort and downtime. In this work, we introduce the first FDA-approved system that combines a 1726-nm laser and efficient contact cooling to treat mild, moderate, and severe acne effectively while ensuring safety and minimal patient discomfort without adjunct pain mitigation techniques. Light transport and bioheat transfer simulations were performed to demonstrate the system's efficacy and selectivity. The resulting thermal damage to the skin and sebaceous glands was modeled using the Arrhenius kinetic model. Numerical simulations demonstrated that combining laser energy and optimal contact cooling could induce a significant temperature increase spatially limited to the sebaceous gland; this results in highly selective targeting and maximum damage to the sebaceous gland while preserving other skin structures. In vivo human facial skin histology results corroborated the simulation results. The studies reported here demonstrate that the presented 1726-nm laser system induces selective photothermolysis of the sebaceous gland, providing a safe and effective method for the treatment of acne vulgaris.


Assuntos
Acne Vulgar , Humanos , Acne Vulgar/radioterapia , Glândulas Sebáceas/patologia , Pele/patologia , Resultado do Tratamento , Lasers
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