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1.
Medicine (Baltimore) ; 100(35): e27069, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34477141

RESUMO

ABSTRACT: To investigate the difference in chorioretinal microcirculation between acute central serous chorioretinopathy (aCSC) and chronic central serous chorioretinopathy (cCSC) using optical coherence tomography angiography.In total, 65 patients previously diagnosed with central serous chorioretinopathy (33 aCSC and 32 cCSC) were included in our cross-sectional study. All patients underwent complete ophthalmologic assessment including logarithm of the minimum angle of resolution best-corrected visual acuity, fundus fluorescein angiography, and optical coherence tomography angiography. Sixty eyes of 60 refractive error and age matched healthy people were selected as control.The vessel density of inner retina in patients with aCSC were higher than that in patients with cCSC (51.32 ±â€Š2.01 vs 49.15 ±â€Š3.68, P = .004), however, the vessel density of superficial choroid layer in aCSC were significantly lower than that in cCSC (49.83 ±â€Š6.96 vs 53.42 ±â€Š6.28, P = .033). Further analysis of the data reveals the presence of a distinct choroidal neovascularization (CNV) in 8 patients (25%) with cCSC while there was no evidence of CNV in patients with aCSC.Our study can contribute to a better understanding of the difference in retinochoroid microcirculation between aCSC and cCSC. The vessel density of inner retina was lower and the vessel density of superficial choroid was higher in cCSC, and patients with cCSC were more susceptible to CNV than patients with aCSC.


Assuntos
Capilares/fisiopatologia , Coriorretinopatia Serosa Central/classificação , Microcirculação/fisiologia , Adulto , Neovascularização de Coroide/fisiopatologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Acuidade Visual/fisiologia
2.
Invest Ophthalmol Vis Sci ; 62(10): 20, 2021 08 02.
Artigo em Inglês | MEDLINE | ID: mdl-34410299

RESUMO

Purpose: Diabetic retinopathy results in vision loss with changes to both retinal blood vessels and neural retina. Recent studies have revealed that animal models of diabetes demonstrate early loss of visual function. We explored the time course of retinal change in three different mouse models of diabetes in a longitudinal study using in vivo measures of retinal structure (optical coherence tomography [OCT]) and visual function (optomotor and pupillary responses). Methods: OCT analysis of retinal microstructure, optokinetic response as a measure of visual acuity, and pupillary response to light stimulation were compared among the db/db, Ins2Akita, and streptozotocin (STZ)-induced mouse models of diabetes at 1.5, 3, 6, and 9 months of diabetes. Results: The db/db, Ins2Akita, and STZ-induced models of diabetes all exhibited vision loss and retinal thinning as disease progressed. Both structural changes and functional measures were significantly correlated with the blood glucose levels. Despite this, vision loss and retinal thinning were not consistently correlated, except for the inner retinal layer thickness at 6 months of diabetes. Conclusions: This longitudinal study compiled structural measures and functional outcome data for type 1 and 2 diabetes mouse models commonly used for diabetes studies and demonstrated an overall decline in retinal-related health in conjunction with weight change and blood glucose alterations. The relationship between the structural change and functional outcome could be correlative but is not necessarily causative, as retinal thinning was not sufficient to explain visual acuity decline.


Assuntos
Diabetes Mellitus Experimental/diagnóstico , Retinopatia Diabética/patologia , Retina/patologia , Vasos Retinianos/patologia , Tomografia de Coerência Óptica/métodos , Acuidade Visual/fisiologia , Animais , Diabetes Mellitus Experimental/fisiopatologia , Retinopatia Diabética/fisiopatologia , Seguimentos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Retina/fisiopatologia , Vasos Retinianos/fisiopatologia
3.
Cell Prolif ; 54(9): e13100, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34347352

RESUMO

OBJECTIVES: To evaluate the long-term biosafety and efficacy of transplantation of human embryonic stem cells-derived retinal pigment epithelial (hESC-RPE) cells in early-stage of Stargardt macular degeneration (STGD1). MATERIALS AND METHODS: Seven patients participated in this prospective clinical study, where they underwent a single subretinal transplantation of 1 × 105 hESC-RPE cells in one eye, whereas the fellow eye served as control. These patients were reassessed for a 60-month follow-up through systemic and ophthalmic examinations. RESULTS: None of the patients experienced adverse reactions systemically or locally, except for two who had transiently high intraocular pressure post-operation. Functional assessments demonstrated that all of the seven operated eyes had transiently increased or stable visual function 1-4 months after transplantation. At the last follow-up visit, two of the seven eyes showed visual function loss than the baseline; however, one of them showed a stable visual acuity when compared with the change of fellow eye. Obvious small high reflective foci in the RPE layer were displayed after the transplantation, and maintained until the last visit. Interestingly, three categories of patients who were classified based on autofluorescence, exhibited distinctive patterns of morphological and functional change. CONCLUSIONS: Subretinal transplantation of hESC-RPE in early-stage STGD1 is safe and tolerated in the long term. Further investigation is needed for choosing proper subjects according to the multi-model image and function assessments.


Assuntos
Células Epiteliais/citologia , Células-Tronco Embrionárias Humanas/citologia , Degeneração Macular/patologia , Epitélio Pigmentado da Retina/citologia , Pigmentos da Retina/fisiologia , Doença de Stargardt/patologia , Adulto , Diferenciação Celular/fisiologia , Linhagem Celular , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Transplante de Células-Tronco/métodos , Acuidade Visual/fisiologia , Adulto Jovem
4.
J Binocul Vis Ocul Motil ; 71(3): 110-117, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34348581

RESUMO

BACKGROUND: The coronavirus (COVID-19) global pandemic has been a poignant reminder of the value of telehealth services to deliver care, especially as a means of reducing the risk of infectious disease transmission caused by close personal contact, decreasing unnecessary travel for medical consultations, and limiting the number of individuals in waiting rooms. The role of telehealth in ophthalmology has historically been limited to store-and-forwarding of images, much like what is used in radiology. PATIENTS AND METHODS: Remote evaluation using two-way audio-video communications over the initial 10-week period of clinic shutdowns. Visual acuity (VA) measurement was attempted using a printed single surrounded HOTV or Snellen chart. The VA measurement of fellow eyes was compared to the prior in person clinical visit. External and strabismus examinations were also conducted. RESULTS: Fifty-eight patients were evaluated with a mean age 12.5 years (range 5 months to 82 years). Twenty of 58 (34%) were younger than 5 years of age. Reasons for evaluation were strabismus in 26 patients (45%), refractive error in 25 (43%), and amblyopia in 10 patients (19%). Recognition visual acuity was obtained in 69% (40 of 58), including every patient older than 5 years of age. Nine children from 2 to 5 years of age (mean 3 years) were unable to perform HOTV VA testing. Of nine children unable to do complete VA testing, five had been premature and seven had developmental delay. There was a mean bias of -0.12 logMAR in favor of the prior in office test in the right eyes of 21 non-amblyopic patients. The 95% limits of agreement between the in-person visit and the subsequent telehealth video visit logMAR VA were +0.20 logMAR upper limit, -0.44 logMAR lower limit. CONCLUSIONS: Telehealth video visits provided basic ophthalmic information in patients who are physically incapable to come to the office, leading to improved triage. Vision could be tested remotely in young children, but we found substantial variability in the measurement of clinically normal eyes. Improvements in the reliability of at-home visual acuity testing are needed.


Assuntos
COVID-19/epidemiologia , Consulta Remota/métodos , SARS-CoV-2 , Estrabismo/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Atropina/administração & dosagem , Criança , Pré-Escolar , Óculos , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Antagonistas Muscarínicos/administração & dosagem , Oftalmologia/métodos , Pediatria/métodos , Consulta Remota/organização & administração , Privação Sensorial , Estrabismo/fisiopatologia , Estrabismo/terapia , Estados Unidos/epidemiologia , Testes Visuais/métodos , Acuidade Visual/fisiologia
5.
Cornea ; 40(11): 1502-1504, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34320598
6.
Invest Ophthalmol Vis Sci ; 62(7): 20, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-34137807

RESUMO

Purpose: Synaptosomal actin dynamics are essential for synaptic structural stability. Whether actin dynamics are involved in structural and functional synaptic plasticity within the primary visual cortex (V1) or behavioral visual acuity in rats has still not been thoroughly investigated. Methods: Synaptosome preparation and western blot analysis were used to analyze synaptosomal actin dynamics. Transmission electron microscopy was used to detect synaptic density and mitochondrial area alterations. A visual water maze task was applied to assess behavioral visual acuity. Microinjection of the actin polymerization inhibitor or stabilizer detected the effect of actin dynamics on visual function. Results: Actin dynamics, the mitochondrial area, and synaptic density within the area of V1 are increased during the critical period for the development of binocularity. Microinjection of the actin polymerization inhibitor cytochalasin D into the V1 decreased the mitochondrial area, synaptic density, and behavioral visual acuity. Long-term monocular deprivation reduced actin dynamics, the mitochondrial area, and synaptic density within the V1 contralateral to the deprived eye compared with those ipsilateral to the deprived eye and impaired visual acuity in the amblyopic eye. In addition, the mitochondrial area, synaptic density, and behavioral visual acuity were improved by stabilization of actin polymerization by jasplakinolide microinjection. Conclusions: During the critical period of visual development of binocularity, synaptosomal actin dynamics regulate synaptic structure and function and play roles in behavioral visual acuity in rats.


Assuntos
Actinas , Plasticidade Neuronal/fisiologia , Sinaptossomos/metabolismo , Acuidade Visual/fisiologia , Córtex Visual/fisiologia , Actinas/química , Actinas/metabolismo , Ambliopia/metabolismo , Ambliopia/fisiopatologia , Animais , Antineoplásicos/farmacologia , Comportamento Animal/fisiologia , Depsipeptídeos/farmacologia , Aprendizagem em Labirinto , Polimerização/efeitos dos fármacos , Ratos , Visão Ocular/fisiologia
7.
Medicine (Baltimore) ; 100(22): e26227, 2021 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-34087903

RESUMO

RATIONALE: Retinopathy of prematurity (ROP) is one of the major leading causes of childhood visual morbidity worldwide. Retinal break and traction develop in regressed ROP can further result in rhegmatogenous or tractional retinal detachment years or even decades later. PATIENT CONCERNS: Here, we reported a case of bilateral ROP related late complication in a 36-year-old male with a chief complaint of increased floaters in his left eye. DIAGNOSES: The fundus examination showed demarcation lines over temporal side in both eyes with tractional retinal detachment and retinal breaks anterior to the lines. A diagnosis of ROP-related late complication of combined tractional and rhegmatogenous retinal detachment was made. INTERVENTIONS: Peripheral laser photocoagulation along the demarcation lines for confining the detachment area in both eyes was performed with a stable condition during follow up. OUTCOMES: After laser retinopexy, the patient was followed up at one week and four months later with stable laser scars and without progression of the retinal detachments. CONCLUSION: Regressed ROP-associated retinal detachment can occur at any time during life. Special care and follow-up may be necessary for these patients.


Assuntos
Fotocoagulação a Laser/métodos , Descolamento Retiniano/diagnóstico , Descolamento Retiniano/terapia , Adulto , Assistência ao Convalescente , Fundo de Olho , Humanos , Fotocoagulação a Laser/efeitos adversos , Masculino , Descolamento Retiniano/etiologia , Perfurações Retinianas/complicações , Retinopatia da Prematuridade/complicações , Retinopatia da Prematuridade/epidemiologia , Resultado do Tratamento , Acuidade Visual/fisiologia
8.
N Z Med J ; 134(1536): 105-112, 2021 06 04.
Artigo em Inglês | MEDLINE | ID: mdl-34140717

RESUMO

AIM: This cross-sectional study aimed to investigate whether presenting visual acuity or patient demographic variables were associated with geographic proximity to primary and secondary ophthalmic services. METHODS: Demographics for all patients referred within the Waikato District between October 2017 and March 2019 that met the threshold for publicly funded cataract surgery were analysed. GPS coordinates for all patient and optometrist addresses were obtained. The driving distance and driving time for each patient to travel to their referring optometrist were calculated. Quality-of-life data were obtained. Analysis of visual acuity, driving distance, age, ethnicity and gender was completed using. Furthermore, a comparative analysis of Maori and New Zealand European defined as having remote access was completed. RESULTS: A total of 1,260 patients were included. Multivariate analysis showed no significant association between driving distance and visual acuity. Comparative analysis of Maori and New Zealand European defined as having remote access showed Maori had significantly worse visual acuity than New Zealand Europeans at the time of referral. No significant difference was found in quality of life. Maori were on average younger than New Zealand European. Driving time and distance were on average 27% longer for Maori compared with New Zealand Europeans defined as having remote access. CONCLUSIONS: Maori presenting with cataract typically are younger and have lower visual acuity than New Zealand European. Longer driving distances represent a potential geographic barrier for Maori to access ophthalmic care and referral to tertiary services. No significant association was found between driving distance and visual acuity.


Assuntos
Condução de Veículo/estatística & dados numéricos , Catarata/terapia , Acesso aos Serviços de Saúde/estatística & dados numéricos , Acuidade Visual/fisiologia , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos , Humanos , Pessoa de Meia-Idade , Nova Zelândia , Grupo com Ancestrais Oceânicos/estatística & dados numéricos
9.
Invest Ophthalmol Vis Sci ; 62(6): 6, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-33944891

RESUMO

Purpose: To investigate the associations between visual function and the optical coherence tomography (OCT) parameters in eyes with idiopathic epiretinal membrane (ERM). Methods: Thirty-nine consecutive eyes with ERM were enrolled. In addition to OCT parameters, such as central retinal thickness (CRT), the area of gap between the ERM and the retinal surface (SUKIMA) was newly defined and calculated from the vertical and horizontal OCT images (SUKIMAv and SUKIMAh). The average of SUKIMAv and SUKIMAh (SUKIMAave) was used for the statistical analysis. The vertical and horizontal metamorphopsia scores (MV, MH) and the average of MV and MH (Mave) were also used for the analysis. Results: The Mave was not significantly associated with logMAR visual acuity (VA) (P = 0.57, linear regression analysis). Analysis using second-order bias-corrected Akaike information criterion model selection identified the age, CRT, and SUKIMAave as being associated with logMAR VA. On the other hand, among the OCT parameters, SUKIMAave and CRT were associated with the Mave. In addition, there was a significant relationship between SUKIMAh and MV (P = 0.011) and between SUKIMAv and MH (P = 0.0014). Conclusions: We identified SUKIMA as a novel OCT parameter that is useful to predict both VA and metamorphopsia in patients with ERM.


Assuntos
Membrana Epirretiniana/fisiopatologia , Tomografia de Coerência Óptica , Transtornos da Visão/fisiopatologia , Acuidade Visual/fisiologia , Idoso , Idoso de 80 Anos ou mais , Membrana Epirretiniana/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Retina/diagnóstico por imagem , Retina/fisiopatologia , Estudos Retrospectivos , Microscopia com Lâmpada de Fenda
10.
Invest Ophthalmol Vis Sci ; 62(6): 4, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-33944893

RESUMO

Purpose: Dichoptic training is becoming a popular tool in amblyopia treatment. Here we investigated the effects of dichoptic demasking training in children with amblyopia who never received patching treatment (NPT group) or were no longer responsive to patching (PT group). Methods: Fourteen NPT and thirteen PT amblyopes (6-16.5 years; 24 anisometropic, two strabismus, and one mixed) received dichoptic demasking training for 17 to 22 sessions. They used the amblyopic eye (AE) to practice contrast discrimination between a pair of Gabors that were dichoptically masked by a band-filtered noise pattern simultaneously presented in the fellow eye (FE). Dichoptic learning was quantified by the increase of maximal tolerable noise contrast (TNC) for AE contrast discrimination. Computerized visual acuities and contrast sensitivity functions for both eyes and the Randot stereoacuity were measured before and after training. Results: Training improved maximal TNC by six to eight times in both groups, along with a boost of AE acuities by 0.15 logMAR (P < 0.001) in the NPT group and 0.06 logMAR (P < 0.001) in the PT group. This visual acuity improvement was significantly dependent on the pretraining acuity. Stereoacuity was significantly improved by 41.6% (P = 0.002) in the NPT group and 64.2% (P < 0.001) in the PT group. The stereoacuity gain was correlated to the pretraining interocular acuity difference (r = -0.49, P = 0.010), but not to the interocular acuity difference change (r = -0.28, P = 0.15). Training improved AE contrast sensitivity in the NPT group (P = 0.009) but not the PT group (P = 0.76). Moreover, the learning effects in 12 retested observers were retained for 10 to 24 months. Conclusions: Dichoptic training can improve, and sometimes even restore, the stereoacuity of amblyopic children, especially those with mild amblyopia (amblyopic VA ≦0.28 logMAR). The dissociation of stereoacuity gain and the interocular acuity difference change suggests that the stereoacuity gain may not result from a reduced interocular suppression in most amblyopes. Rather, the amblyopes may have learned to attend to, or readout, the stimulus information to improve stereopsis.


Assuntos
Ambliopia/terapia , Aprendizagem por Associação/fisiologia , Visão Binocular/fisiologia , Acuidade Visual/fisiologia , Percepção Visual/fisiologia , Adolescente , Ambliopia/fisiopatologia , Criança , Feminino , Humanos , Masculino , Privação Sensorial
11.
Invest Ophthalmol Vis Sci ; 62(6): 15, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-33984120

RESUMO

Purpose: Children with cerebral visual impairment (CVI) often have abnormal visual orienting behaviors due to impaired or damaged visual cortex. Alternatively, visual-cortical function is intact but visual information is not transformed downstream into an appropriate oculomotor output (visuomotor dysfunction). We examined visual, anatomic, and oculomotor assessments to distinguish visuomotor dysfunction from CVI associated with severely reduced visual-cortical response. Methods: We reviewed the medical records from children with CVI having abnormal visual orienting behaviors, normal ocular examinations, and born near term. Relevant data were visual evoked potentials (VEPs), Teller card acuity, eye movements recorded by video-oculography (VOG), and neuroimaging (magnetic resonance imaging [MRI]) including diffusion tensor imaging (DTI) tractography. Results: Thirty subjects had visuomotor dysfunction based on a normal VEP; of these 33% had a normal MRI and 67% had white matter abnormalities associated with metabolic disease and/or decreased volume of brain parenchyma. VOG recordings showed smooth pursuit gains were uniformly reduced and saccades were dysmetric but followed the main sequence. Ten subjects had severe CVI based on VEPs at noise levels; visual acuities and MRI findings overlapped those of the visuomotor dysfunction group. Developmental delay, seizures, microcephaly, and hypotonia were common across all groups. All subjects with an abnormal conventional MRI had abnormal metrics on DTI tractography from the occipital lobe. Conclusions: A subset of patients with CVI have abnormal visual orienting behaviors despite a normal VEP (visuomotor dysfunction). A majority have abnormal white matter metrics on tractography suggesting a downstream defect in sensorimotor transformation. Clinically, visuomotor dysfunction is indistinguishable from severe CVI.


Assuntos
Cegueira Cortical/fisiopatologia , Potenciais Evocados Visuais/fisiologia , Córtex Visual/fisiopatologia , Substância Branca/patologia , Cegueira Cortical/diagnóstico por imagem , Pré-Escolar , Feminino , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Acompanhamento Ocular Uniforme , Movimentos Sacádicos/fisiologia , Acuidade Visual/fisiologia , Córtex Visual/diagnóstico por imagem , Substância Branca/diagnóstico por imagem
12.
Invest Ophthalmol Vis Sci ; 62(6): 19, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-34008001

RESUMO

Purpose: The PROM1 p.Arg373Cys variant has been reported to cause dominant Stargardt disease, cone-rod dystrophy, and occasionally retinitis pigmentosa. This study aimed to evaluate the common phenotype associated with this variant in Chinese patients. Methods: Variants in PROM1 were collected from in-house exome data. Potential pathogenic variants were selected, verified, and then confirmed by Sanger sequencing and co-segregation analysis. Ocular phenotypes were reviewed and further clarified by ophthalmologic examinations. Results: The heterozygous c.1117C>T (p.Arg373Cys) variant was identified in four unrelated families, and biallelic variants were detected in three families. Of the 10 patients from four families with the p.Arg373Cys variant, six patients from three families who underwent full fundus examination demonstrated various degrees of macular dystrophy, as well as typical bone-spicule pigment deposits in the peripheral retina. The remaining four patients did not undergo a full dilated fundus examination. A relatively preserved zone was observed between the macular and peripheral lesions. Electroretinography results showed cone and rod involvement in three patients. Conclusions: Unlike Stargardt disease alone, which was considered to be the main phenotype of the p.Arg373Cys variant, all patients with full-field fundus examination in our study presented with macular dystrophy plus peripheral retinopathy resembling retinitis pigmentosa. Different phenotypes associated with the p.Arg373Cys variant may actually reflect different stages of the same disease: a predominant central cone phenotype at an early stage and peripheral rod involvement as degeneration progresses. Evaluation of the full fundus, especially the peripheral region in additional patients, is expected to confirm our findings.


Assuntos
Antígeno AC133/genética , Grupo com Ancestrais do Continente Asiático/genética , Degeneração Macular/genética , Mutação de Sentido Incorreto/genética , Retinite Pigmentosa/genética , Adulto , Idoso , China/epidemiologia , Feminino , Angiofluoresceinografia , Humanos , Degeneração Macular/diagnóstico , Masculino , Pessoa de Meia-Idade , Osteófito , Linhagem , Fenótipo , Retinite Pigmentosa/diagnóstico , Acuidade Visual/fisiologia , Sequenciamento Completo do Exoma , Adulto Jovem
13.
Invest Ophthalmol Vis Sci ; 62(6): 22, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-34015078

RESUMO

Purpose: Autosomal recessive bestrophinopathy (ARB) and vitelliform macular dystrophy (VMD) are distinct phenotypes, typically inherited through recessive and dominant patterns, respectively. Recessively inherited VMD (arVMD) has been reported, suggesting that dominant and recessive BEST1-related retinopathies represent a single disease spectrum. This study compares adVMD, arVMD, and ARB to determine whether a continuum exists and to define clinical and genetic features to aid diagnosis and management. Methods: One arVMD patient and nine ARB patients underwent standard ophthalmic examination, imaging, electrophysiology, and genetic assessments. A meta-analysis of reported BEST1 variants was compiled, and clinical parameters were analyzed with regard to inheritance and phenotype. Results: Among 10 patients with biallelic BEST1 variants, three novel ARB variants (p.Asp118Ala, p.Leu224Gln, p.Val273del) were discovered. A patient with homozygous p.Glu35Lys was clinically unique, presenting with VMD, including hyperautofluorescence extending beyond the macula, peripheral punctate lesions, and shortened axial-length. A tritan-axis color vision deficit was seen in three of six (50%) of ARB patients. Attempts to distinguish recessively-inherited ARB and dominantly-inherited VMD genotypically, by variant frequency and residue location, did not yield significant differences. Literature meta-analysis with principle component analysis of clinical features demonstrated a spectrum of disease with arVMD falling between adVMD and ARB. Conclusions: This study suggests that arVMD is part of a continuum of autosomal recessive and dominant BEST1-related retinopathies. Detailed clinical and molecular assessments of this cohort and the literature are corroborated by unsupervised analysis, highlighting the overlapping heterogeneity among BEST1-associated clinical diagnoses. Tritan-axis color vision deficit is a previously unreported finding associated with ARB.


Assuntos
Bestrofinas/genética , Oftalmopatias Hereditárias/genética , Doenças Retinianas/genética , Distrofia Macular Viteliforme/genética , Adulto , Criança , Pré-Escolar , Defeitos da Visão Cromática/genética , Análise Mutacional de DNA , Eletroculografia , Eletrorretinografia , Oftalmopatias Hereditárias/diagnóstico , Oftalmopatias Hereditárias/fisiopatologia , Feminino , Genética , Humanos , Masculino , Metanálise como Assunto , Pessoa de Meia-Idade , Mutação/genética , Linhagem , Fenótipo , Doenças Retinianas/diagnóstico , Doenças Retinianas/fisiopatologia , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia , Distrofia Macular Viteliforme/diagnóstico , Distrofia Macular Viteliforme/fisiopatologia , Adulto Jovem
14.
PLoS One ; 16(5): e0242394, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34048428

RESUMO

While albino mice are widely used in research which includes the use of visually guided behavioral tests, information on their visual capability is scarce. We compared the spatial resolution (acuity) of albino mice (BALB/c) with that of pigmented mice (C57BL/6J). We used a high-throughput pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) method for objective assessment of retinal and cortical acuity, as well as optomotor head-tracking response/ reflex (OMR). We found that PERG, PVEP, and OMR acuities of C57BL/6J mice were all in the range of 0.5-0.6 cycles/degree (cyc/deg). BALB/c mice had PERG and PVEP acuities in the range of 0.1-0.2 cyc/deg but were unresponsive to OMR stimulus. Results indicate that retinal and cortical acuity can be reliably determined with electrophysiological methods in BALB/c mice, although PERG/PVEP acuities are lower than those of C57BL/6J mice. The reduced acuity of BALB/c mice appears to be primarily determined at retinal level.


Assuntos
Potenciais Evocados Visuais/fisiologia , Retina/fisiologia , Visão Ocular/fisiologia , Acuidade Visual/fisiologia , Animais , Eletrorretinografia , Potenciais Evocados Visuais/genética , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Retina/diagnóstico por imagem , Visão Ocular/genética , Acuidade Visual/genética , Vias Visuais
15.
Optom Vis Sci ; 98(5): 446-449, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33967251

RESUMO

SIGNIFICANCE: This report details how a case with degenerative myopia and symptoms secondary to laser peripheral iridotomies is managed with a modified piggyback contact lens system. The benefits of using a system with tinted and gas-permeable (GP) lenses are discussed. PURPOSE: This study aimed to report the positive outcome of a modified piggyback system in the treatment of degenerative myopia and iris abnormalities. CASE REPORT: A patient with degenerative myopia presented with visual disturbances secondary to laser peripheral iridotomies in both eyes. A modified piggyback system was trialed using a corneal GP lens overlaying a tinted soft contact lens to provide optimal vision and visual comfort in both eyes. After optimizing the fit, there was a reduction in glare and improved vision. CONCLUSIONS: Hard contact lenses often provide superior optics and vision compared with soft lenses, especially to patients with high refractive errors. Patients who require hard lenses and also have visual disturbances secondary to iris abnormalities could be managed with a modified piggyback contact lens systems using a corneal GP lens and tinted soft lens.


Assuntos
Lentes de Contato Hidrofílicas , Iridectomia , Doenças da Íris/terapia , Miopia Degenerativa/terapia , Humanos , Doenças da Íris/fisiopatologia , Terapia a Laser , Masculino , Pessoa de Meia-Idade , Miopia Degenerativa/fisiopatologia , Transtornos da Visão/fisiopatologia , Transtornos da Visão/terapia , Acuidade Visual/fisiologia
16.
Optom Vis Sci ; 98(5): 483-489, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33967252

RESUMO

SIGNIFICANCE: This pilot study compared subjective and objective vision of children wearing single-vision and +2.00, +3.00, and +4.00 D add power soft multifocal contact lenses to determine whether the higher add power-thought to provide better myopia control-resulted in visual compromise. PURPOSE: This study aimed to determine the maximum add power children wearing center-distance soft multifocal contact lenses could accept objectively and subjectively. METHODS: Myopic children were assigned in random order to wear omafilcon A single-vision or multifocal "D" contact lenses with +2.00, +3.00, or +4.00 D add power for 1 week each. High-contrast distance and near visual acuity, low-contrast distance visual acuity, and contrast sensitivity were measured at each visit along with a quality of vision questionnaire to assess their vision. The Friedman test was performed to evaluate the impact of add power on all outcome measures. RESULTS: Eleven subjects were enrolled, and nine subjects completed the study. The median age of completed subjects was 11 years. Median logMAR low-contrast distance visual acuity was reduced in the +3.00 (+0.20) and +4.00 (+0.28) D add lenses compared with the +2.00 (+0.16) D add and single-vision lenses (+0.10, P < .001). All three multifocal lenses resulted in reduced contrast sensitivity (+1.35 to +1.40) compared with single-vision lenses (+1.60, P < .001). In general, +3.00 and +4.00 D add lenses resulted in worse glare/starbursts, ghost images, computer vision, changing fixation distance, and overall vision, but results varied. There were no differences among the lenses with respect to subjective assessments of distance vision, near vision, strain or tiredness, contact lens comfort, or sporting activities. CONCLUSIONS: The +3.00 D and higher add powers result in more objective and subjective vision-related issues than single-vision lenses, but the +2.00 D add multifocal lenses were well tolerated.


Assuntos
Lentes de Contato Hidrofílicas , Sensibilidades de Contraste/fisiologia , Miopia/terapia , Acuidade Visual/fisiologia , Criança , Feminino , Humanos , Masculino , Miopia/fisiopatologia , Projetos Piloto , Inquéritos e Questionários
17.
Optom Vis Sci ; 98(5): 437-439, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33973909

RESUMO

SIGNIFICANCE: We report the use of anterior segment optical coherence tomography (AS-OCT) as a valuable tool for capsular block syndrome diagnosis and follow-up. PURPOSE: The purposes of this study are to report a case of late-onset capsular block syndrome or lacteocrumenasia and to describe differential diagnosis with other more common phacoemulsification complications such as intraocular lens (IOL) or posterior capsule opacification. CASE REPORT: We report the case of a 56-year-old man with a clinical history of cataract surgery in his left eye. Five years after cataract surgery, he complained of blurred vision and was referred for IOL removal to our hospital. After careful slit-lamp examination, we found that the lens was clear, and opacity belonged to the accumulation of a whitish material in the capsular bag behind the lens. AS-OCT gave the definite diagnosis of capsular block syndrome. Intraocular lens removal had been wrongly indicated, and we treated our patient by YAG laser posterior capsulotomy. AS-OCT confirmed the absence of a further accumulated material, so no other interventions were needed. After treatment, best-corrected visual acuity improved from 0.48 to 0.1 logMAR. CONCLUSIONS: Capsular block syndrome is a rare late-onset complication of cataract surgery causing a deep visual acuity decay. A precise slit-lamp examination and AS-OCT, together, avoid misdiagnosis and unnecessary surgical treatment, which may be needed in case of IOL opacity or fibrotic-like lacteocrumenasia. AS-OCT also helps in determining the treatment outcome. Immediate best-corrected visual acuity improvement is reached after a successful intervention.


Assuntos
Opacificação da Cápsula/diagnóstico por imagem , Cápsula Posterior do Cristalino/diagnóstico por imagem , Complicações Pós-Operatórias , Tomografia de Coerência Óptica , Opacificação da Cápsula/etiologia , Opacificação da Cápsula/fisiopatologia , Opacificação da Cápsula/cirurgia , Humanos , Implante de Lente Intraocular , Masculino , Pessoa de Meia-Idade , Facoemulsificação , Cápsula Posterior do Cristalino/fisiopatologia , Cápsula Posterior do Cristalino/cirurgia , Capsulotomia Posterior , Tomografia de Coerência Óptica/métodos , Transtornos da Visão/fisiopatologia , Acuidade Visual/fisiologia
18.
BMJ Health Care Inform ; 28(1)2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-34035050

RESUMO

BACKGROUND/AIMS: To assess the outcomes of home monitoring of distortion caused by macular diseases using a smartphone-based application (app), and to examine them with hospital-based assessments of visual acuity (VA), optical coherence tomography-derived central macular thickness (CMT) and the requirement of intravitreal injection therapy. DESIGN: Observational study with retrospective analysis of data. METHODS: Participants were trained in the correct use of the app (Alleye, Oculocare, Zurich, Switzerland) in person or by using video and telephone consultations. Automated threshold-based alerts were communicated based on a traffic light system. A 'threshold alarm' was defined as three consecutive 'red' scores, and turned into a 'persistent alarm' if present for greater than a 7-day period. Changes of VA and CMT, and the requirement for intravitreal therapy after an alarm were examined. RESULTS: 245 patients performing a total of 11 592 tests (mean 46.9 tests per user) were included and 85 eyes (164 alarms) examined. Mean drop in VA from baseline was -4.23 letters (95% CI: -6.24 to -2.22; p<0.001) and mean increase in CMT was 29.5 µm (95% CI: -0.08 to 59.13; p=0.051). Sixty-six eyes (78.5%) producing alarms either had a drop in VA, increase in CMT or both and 60.0% received an injection. Eyes with persistent alarms had a greater loss of VA, -4.79 letters (95% CI: -6.73 to -2.85; p<0.001) or greater increase in CMT, +87.8 µm (95% CI: 5.2 to 170.4; p=0.038). CONCLUSION: Smartphone-based self-tests for macular disease may serve as reliable indicators for the worsening of pathology and the need for treatment.


Assuntos
Injeções Intravítreas/estatística & dados numéricos , Degeneração Macular , Consulta Remota/estatística & dados numéricos , Smartphone , Acuidade Visual/fisiologia , Idoso , Feminino , Humanos , Degeneração Macular/diagnóstico , Degeneração Macular/patologia , Masculino , Aplicativos Móveis , Estudos Retrospectivos , Tomografia de Coerência Óptica
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