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1.
Int J Mol Sci ; 22(5)2021 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-33807577

RESUMO

Inflammation is a well-characterized critical driver of gastrointestinal cancers. Previous findings have shown that intestinal low-grade inflammation can be promoted by the consumption of select dietary emulsifiers, ubiquitous component of processed foods which alter the composition and function of the gut microbiota. Using a model of colitis-associated cancer, we previously reported that consumption of the dietary emulsifiers carboxymethylcellulose or polysorbate-80 exacerbated colonic tumor development. Here, we investigate the impact of dietary emulsifiers consumption on cancer initiation and progression in a genetical model of intestinal adenomas. In APCmin mice, we observed that dietary emulsifiers consumption enhanced small-intestine tumor development in a way that appeared to be independent of chronic intestinal inflammation but rather associated with emulsifiers' impact on the proliferative status of the intestinal epithelium as well as on intestinal microbiota composition in both male and female mice. Overall, our findings further support the hypothesis that emulsifier consumption may be a new modifiable risk factor for colorectal cancer (CRC) and that alterations in host-microbiota interactions can favor gastrointestinal carcinogenesis in individuals with a genetical predisposition to such disorders.


Assuntos
Adenoma/induzido quimicamente , Neoplasias Colorretais/induzido quimicamente , Dieta/efeitos adversos , Emulsificantes/efeitos adversos , Trato Gastrointestinal/efeitos dos fármacos , Intestinos/efeitos dos fármacos , Animais , Carboximetilcelulose Sódica/química , Carcinogênese/induzido quimicamente , Proliferação de Células/efeitos dos fármacos , Feminino , Aditivos Alimentares/efeitos adversos , Microbioma Gastrointestinal/efeitos dos fármacos , Inflamação/induzido quimicamente , Mucosa Intestinal/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Polissorbatos/química
5.
Medicine (Baltimore) ; 100(14): e25306, 2021 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-33832102

RESUMO

ABSTRACT: Pituitary tumors commonly cause visual impairment and the degree of impairment can depend on the size, location, and type of the tumor. However, no studies have been made regarding the differences caused by functioning pituitary adenoma (FPA) and non-functioning pituitary adenoma (NFPA). We aimed to investigate the relationship between clinical characteristics and visual impairment in patients with FPA and NFPA.This case series study included 73 pituitary adenoma patients. All patients underwent ophthalmic evaluations, and we retrospectively reviewed their medical records. Tumor types were confirmed by histological analysis, and the tumor volume was calculated. Magnetic resonance imaging was used to determine the tumor diameter. The observation indices of the two groups were compared. The correlation between the visual field and tumor volume was analysed using scatter plots.We enrolled 30 patients in the FPA group and 43 in the NFPA group. The first symptoms presented in the eyes in 23% of FPA patients and 41.9% of NFPA patients. The best-corrected visual acuity of the FPA group was better than that of the NFPA group, and 34 (56.7%) and 73 (84.9%) eyes in these groups had visual field defects, respectively. The visual field defects of the FPA patients were lighter than those of the NFPA patients. Except for the anteroposterior diameter, there were no differences in the other parameters of tumor diameter between the groups. The tumor volume of the FPA group was smaller than that of the NFPA group. The tumor size was positively correlated with the mean deviation and negatively correlated with the mean sensitivity in both groups.There was a longer delay between the onset of signs and symptoms and treatment in the FPA group than in the NFPA group. Future studies should focus on visual field defects caused by FPA and NFPA.


Assuntos
Adenoma/complicações , Adenoma/patologia , Neoplasias Hipofisárias/complicações , Neoplasias Hipofisárias/patologia , Transtornos da Visão/etiologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo , Carga Tumoral/fisiologia , Adulto Jovem
6.
Nat Commun ; 12(1): 2281, 2021 04 16.
Artigo em Inglês | MEDLINE | ID: mdl-33863879

RESUMO

Interleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in multiple cellular responses, including tumor development. However, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood. To characterize IL-11+ cells in vivo, we generate Il11 reporter mice. IL-11+ cells appear in the colon in murine tumor and acute colitis models. Il11ra1 or Il11 deletion attenuates the development of colitis-associated colorectal cancer. IL-11+ cells express fibroblast markers and genes associated with cell proliferation and tissue repair. IL-11 induces the activation of colonic fibroblasts and epithelial cells through phosphorylation of STAT3. Human cancer database analysis reveals that the expression of genes enriched in IL-11+ fibroblasts is elevated in human colorectal cancer and correlated with reduced recurrence-free survival. IL-11+ fibroblasts activate both tumor cells and fibroblasts via secretion of IL-11, thereby constituting a feed-forward loop between tumor cells and fibroblasts in the tumor microenvironment.


Assuntos
Adenoma/imunologia , Colite/patologia , Neoplasias Colorretais/imunologia , Fibroblastos/imunologia , Interleucina-11/metabolismo , Recidiva Local de Neoplasia/epidemiologia , Adenoma/genética , Adenoma/mortalidade , Adenoma/cirurgia , Idoso , Idoso de 80 Anos ou mais , Animais , Linhagem Celular Tumoral , Colite/induzido quimicamente , Colite/imunologia , Colo/citologia , Colo/imunologia , Colo/patologia , Colo/cirurgia , Neoplasias Colorretais/genética , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/cirurgia , Sulfato de Dextrana/administração & dosagem , Sulfato de Dextrana/toxicidade , Modelos Animais de Doenças , Intervalo Livre de Doença , Feminino , Fibroblastos/metabolismo , Regulação Neoplásica da Expressão Gênica/imunologia , Técnicas de Silenciamento de Genes , Genes Reporter , Proteínas de Fluorescência Verde/genética , Humanos , Interleucina-11/genética , Subunidade alfa de Receptor de Interleucina-11/genética , Subunidade alfa de Receptor de Interleucina-11/metabolismo , Mucosa Intestinal/citologia , Mucosa Intestinal/imunologia , Mucosa Intestinal/patologia , Estimativa de Kaplan-Meier , Masculino , Camundongos , Camundongos Knockout , Camundongos Transgênicos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/imunologia , Organoides , Cultura Primária de Células , Estudos Retrospectivos , Transcriptoma/imunologia , Microambiente Tumoral/imunologia
7.
Pathologe ; 42(3): 333-351, 2021 May.
Artigo em Alemão | MEDLINE | ID: mdl-33877399

RESUMO

The 2017 WHO classification of pituitary tumors is still based on structural analyses and expression of various pituitary hormones. Three innovations have to be considered: (1) The expression of pituitary transcription factors Pit­1, T­Pit and SF­1. (2) The term "atypical adenoma" was replaced by "aggressive adenoma". (3) The three tumor types of the neurohypophysis (pituicytoma, spindle cell oncocytoma, granular cell tumor) are defined by their common expression of TTF­1. Craniophyryngiomas are identified as adamantinomatous type by focal nuclear expression of ß­catenin or as papillary type by demonstration of BRAF V600E mutation. Further primary tumors of the pituitary are extremely rare. These and also the other tumors of the sellar region can be structurally very similar to pituitary adenomas but can be-nearly without exception-differentiated by immunocytochemistry.


Assuntos
Adenoma , Craniofaringioma , Neuro-Hipófise , Neoplasias Hipofisárias , Adenoma/genética , Humanos , Neoplasias Hipofisárias/genética , Organização Mundial da Saúde
8.
Zhonghua Bing Li Xue Za Zhi ; 50(5): 458-464, 2021 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-33915651

RESUMO

Objective: To observe the clinicopathological features of bronchiolar adenoma (BA) and mixed squamous cell and glandular papilloma (MSGP). The relationship between them was also analyzed. Methods: Clinical data of eight patients with BA and four patients with MSGP diagnosed in China-Japan Friendship Hospital were collected from January 2018 to January 2020. Hematoxylin-eosin staining and immunohistochemical staining (EnVision method) were used to compare their histopathological characteristics. The hotspots regions of cancer-associated driver genes in lung cancer, using real-time quantitative PCR, were detected in all the cases and the literatures were reviewed. Results: The clinical and imaging manifestations of BA and MSGP were analogous. Histologically they had a two-layer structure including bronchial or bronchiolar-type epithelium and a continuous layer of basal cells,similar to bronchial/bronchiole mucosae. P16 protein was highly expressed in 7/8 of BA and 1/4 of MSGP. Mutations of cancer-associated genes were detected in 4/8 of BA, but none in MSGP. Conclusions: BA and MSGP, derived from different parts of the respiratory tract in the lungs, are rare and benign. Their morphological features overlapped with each other, and some cases are accompanied by genetic changes. It is necessary to pay attention to the differential diagnosis between them and lung adenocarcinoma, especially during the intraoperative diagnosis; and be alert to the potentially malignant components in the tumor or combined cancers.


Assuntos
Adenoma , Neoplasias Pulmonares , Papiloma , Adenoma/genética , Bronquíolos , China , Células Epiteliais , Humanos , Neoplasias Pulmonares/genética , Papiloma/genética
9.
Sensors (Basel) ; 21(8)2021 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-33920357

RESUMO

A colonoscopy is a medical examination used to check disease or abnormalities in the large intestine. If necessary, polyps or adenomas would be removed through the scope during a colonoscopy. Colorectal cancer can be prevented through this. However, the polyp detection rate differs depending on the condition and skill level of the endoscopist. Even some endoscopists have a 90% chance of missing an adenoma. Artificial intelligence and robot technologies for colonoscopy are being studied to compensate for these problems. In this study, we propose a self-supervised monocular depth estimation using spatiotemporal consistency in the colon environment. It is our contribution to propose a loss function for reconstruction errors between adjacent predicted depths and a depth feedback network that uses predicted depth information of the previous frame to predict the depth of the next frame. We performed quantitative and qualitative evaluation of our approach, and the proposed FBNet (depth FeedBack Network) outperformed state-of-the-art results for unsupervised depth estimation on the UCL datasets.


Assuntos
Adenoma , Inteligência Artificial , Colonoscópios , Colonoscopia , Retroalimentação , Humanos
10.
BMC Cancer ; 21(1): 207, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33648461

RESUMO

BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers worldwide; it is the fourth leading cause of death in the world and the third in Brazil. Mutations in the APC, DCC, KRAS and TP53 genes have been associated with the progression of sporadic CRC, occurring at defined pathological stages of the tumor progression and consequently modulating several genes in the corresponding signaling pathways. Therefore, the identification of gene signatures that occur at each stage during the CRC progression is critical and can present an impact on the diagnosis and prognosis of the patient. In this study, our main goal was to determine these signatures, by evaluating the gene expression of paired colorectal adenoma and adenocarcinoma samples to identify novel genetic markers in association to the adenoma-adenocarcinoma stage transition. METHODS: Ten paired adenoma and adenocarcinoma colorectal samples were subjected to microarray gene expression analysis. In addition, mutations in APC, KRAS and TP53 genes were investigated by DNA sequencing in paired samples of adenoma, adenocarcinoma, normal tissue, and peripheral blood from ten patients. RESULTS: Gene expression analysis revealed a signature of 689 differentially expressed genes (DEG) (fold-change> 2, p< 0.05), between the adenoma and adenocarcinoma paired samples analyzed. Gene pathway analysis using the 689 DEG identified important cancer pathways such as remodeling of the extracellular matrix and epithelial-mesenchymal transition. Among these DEG, the ETV4 stood out as one of the most expressed in the adenocarcinoma samples, further confirmed in the adenocarcinoma set of samples from the TCGA database. Subsequent in vitro siRNA assays against ETV4 resulted in the decrease of cell proliferation, colony formation and cell migration in the HT29 and SW480 colorectal cell lines. DNA sequencing analysis revealed KRAS and TP53 gene pathogenic mutations, exclusively in the adenocarcinomas samples. CONCLUSION: Our study identified a set of genes with high potential to be used as biomarkers in CRC, with a special emphasis on the ETV4 gene, which demonstrated involvement in proliferation and migration.


Assuntos
Adenocarcinoma/genética , Adenoma/genética , Neoplasias Colorretais/genética , Genes Neoplásicos , Proteínas de Neoplasias/fisiologia , Proteínas Proto-Oncogênicas c-ets/fisiologia , Adenocarcinoma/química , Adenocarcinoma/patologia , Adenoma/química , Adenoma/patologia , Idoso , Biomarcadores Tumorais/genética , Brasil , Divisão Celular/genética , Linhagem Celular Tumoral , Movimento Celular/genética , Transformação Celular Neoplásica/genética , Neoplasias Colorretais/química , Neoplasias Colorretais/patologia , DNA de Neoplasias/genética , Progressão da Doença , Feminino , Regulação Neoplásica da Expressão Gênica , Ontologia Genética , Humanos , Masculino , Pessoa de Meia-Idade , Proteínas de Neoplasias/antagonistas & inibidores , Proteínas de Neoplasias/genética , Proteínas Proto-Oncogênicas c-ets/antagonistas & inibidores , Proteínas Proto-Oncogênicas c-ets/genética , Interferência de RNA , RNA Interferente Pequeno/genética , RNA Interferente Pequeno/farmacologia , Análise Serial de Tecidos , Transcriptoma , Ensaio Tumoral de Célula-Tronco
11.
Endoscopy ; 53(4): v18, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33780980

Assuntos
Adenoma , Humanos
12.
South Med J ; 114(4): 199-206, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33787931

RESUMO

OBJECTIVES: Endoscopic mucosal resection (EMR) is an alternative to surgery for the treatment of large laterally spreading lesions. Residual or recurrent adenoma is a major limitation. This study aimed to quantify early and late recurrences and to assess its associated risk factors. METHODS: The study was a single-center, multiendoscopist, longitudinal study conducted between January 1, 2013 and April 26, 2017. A total of 480 patients with 500 polyps who underwent an endoscopic resection were included. Surveillance colonoscopy (SC) was performed at 4 to 6 months (SC1) and 16 to 18 months (SC2). RESULTS: At SC1, early recurrence was noted in 77 of 354 (21.8%) lesions; 76 (98.7%) were treated endoscopically. The remaining 277 of 354 (78.2%) lesions had no recurrence at SC1; only 41 lesions (15%) were followed up at SC2. Recurrence at SC2 was found in 4 lesions (9.8%), all of which were treated endoscopically. Lesion size >40 mm was associated with recurrence. Recurrence at both SC1 and SC2 was successfully treated endoscopically in 78 of 81 lesions (96.3%). CONCLUSIONS: EMR is an effective, minimally invasive technique for the treatment of large laterally spreading lesions. Although recurrence is a concern, its risk is low (21.8% on SC1 and 9.8% on SC2) and was managed endoscopically in 96.3% cases on follow-up endoscopy.


Assuntos
Adenoma/cirurgia , Neoplasias do Colo/cirurgia , Pólipos do Colo/cirurgia , Ressecção Endoscópica de Mucosa , Recidiva Local de Neoplasia/epidemiologia , Adenoma/diagnóstico por imagem , Adenoma/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias do Colo/diagnóstico por imagem , Neoplasias do Colo/patologia , Pólipos do Colo/diagnóstico por imagem , Pólipos do Colo/patologia , Colonoscopia , Ressecção Endoscópica de Mucosa/métodos , Feminino , Seguimentos , Humanos , Modelos Logísticos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico por imagem , Recidiva Local de Neoplasia/etiologia , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
13.
Can Vet J ; 62(3): 226-232, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33692576

RESUMO

A 34-year-old female greater sulfur-crested cockatoo (Cacatua galerita galerita) was referred for suspected left globe rupture. Ophthalmic examination revealed effacement of the anterior chamber and cornea by a large mass. The left eye was enucleated due to suspicion of globe rupture, secondary to a neoplastic process or chronic trauma. Histopathological examination revealed complete effacement of the internal ocular structures by a neoplasm morphologically consistent with an iridociliary adenoma. The diagnosis was confirmed by Periodic acid-Schiff histochemistry and immunohistochemistry for S100, Melan-A/PNL2, and vimentin antigens. The cockatoo recovered well from surgery, with appropriate healing of the enucleation site, and no evidence of recurrence at 1-year follow-up. Key clinical message: To the authors' knowledge, this is the first report of iridociliary adenoma in a greater sulfur-crested cockatoo, and the third report of such a neoplasm in a psittacine species with a description of the use of immunohistochemistry to confirm a diagnosis of a rare tumor in a bird species.


Assuntos
Adenoma , Doenças das Aves , Cacatuas , Adenoma/veterinária , Animais , Doenças das Aves/diagnóstico , Doenças das Aves/cirurgia , Feminino , Recidiva Local de Neoplasia/veterinária , Enxofre
15.
Anticancer Res ; 41(3): 1515-1521, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33788744

RESUMO

BACKGROUND/AIM: We recently noticed in nonpolypoid adenomas (NPA) and the adjacent normal mucosa, nondysplastic crypts in symmetric and asymmetric fission (NDCSAF). PATIENTS AND METHODS: All NDCSAF found in 80 small NPA and in the adjacent mucosa were registered. RESULTS: A total of 178 NDCSAF (mean, 2.2) were found: 12 (6.7%) interspersed between adenomatous glands, 36 (20.2%) partially replaced by dysplastic epithelium, and 130 (73%) underneath the adenomatous tissue. Of the 61 cases with normal mucosa adjacent to NPA, 40 (65.6%) disclosed NDCSAF, and the remaining 21 (34.4%) normal crypts, exclusively. CONCLUSION: The accruing of NDCSAF within NPA and surrounding mucosa, are outstanding findings. Given that colonic crypts may undergo only one fission every 30-40 years, the accruing of NDCSAF in and about small NPA reveals mucosal hubs with pathological aberrations of cryptogenesis, probably conveyed by somatic mutations. The findings support the existence of field cancerization in the colonic mucosa.


Assuntos
Adenoma/patologia , Colo/patologia , Neoplasias do Colo/patologia , Mucosa Intestinal/patologia , Humanos
16.
Medicine (Baltimore) ; 100(13): e25377, 2021 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-33787642

RESUMO

RATIONALE: Female adnexal tumors of probable Wolffian origin (FATWOs) are rare gynecologic neoplasms arising from the mesonephric duct remnants. Less than 90 cases have been reported in the English literature. Although most cases of FATWO are considered benign, recurrence and metastasis may occur in very few cases during the course of the disease. Due to the small number of recurrent and metastatic FATWO cases, there are no clear recommendations regarding optimal treatment. PATIENT CONCERNS: A 75-year-old postmenopausal woman, who underwent a mass excision of the right broad ligament three years ago, was found to have a right adnexal mass during a regular postoperative physical examination. DIAGNOSES: Vaginal ultrasound examination revealed a cystic and solid mass approximately 3.6 × 4.4 × 3.8 cm on the right side of the uterus. Three years ago, the mass of the right broad ligament was diagnosed with FATWO in the local hospital. Following extensive immunohistochemistry analysis and after reviewing the histology slides from the primary tumor, the final diagnosis of the mass on the right side of the uterus was recurrent and metastatic FATWO. INTERVENTIONS: The patient underwent laparoscopic mass excision, hysterectomy and resection of the metastatic lesion in the small intestine, and then she received 6 cycles of docetaxel and carboplatin-based chemotherapy. OUTCOMES: The disease has recurred three years after the first surgery in the local hospital. After the second surgery followed by systemic chemotherapy, there is no evidence of recurrence with 24 months of follow-up till now. LESSONS: FATWO is considered a benign entity. However, a few FATWOs have been shown to behave aggressively. Due to only a few reported cases, there are no comprehensive recommendations regarding the optimal clinical management of recurrent and metastatic FATWOs. Complete surgical resection followed by combination chemotherapy is considered to be the most effective therapy for recurrent and metastatic FATWOs. Chemotherapy with docetaxel plus carboplatin, which is most commonly used in malignant cases, may be effective in the treatment of recurrent and metastatic FATWOs.


Assuntos
Adenoma/diagnóstico , Doenças dos Anexos/diagnóstico , Neoplasias Intestinais/diagnóstico , Recidiva Local de Neoplasia/diagnóstico , Adenoma/patologia , Adenoma/terapia , Doenças dos Anexos/patologia , Doenças dos Anexos/terapia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ligamento Largo/diagnóstico por imagem , Ligamento Largo/patologia , Ligamento Largo/cirurgia , Quimioterapia Adjuvante , Feminino , Humanos , Histerectomia , Neoplasias Intestinais/secundário , Neoplasias Intestinais/terapia , Intestino Delgado/patologia , Intestino Delgado/cirurgia , Laparoscopia , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/terapia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Ultrassonografia
17.
No Shinkei Geka ; 49(2): 301-315, 2021 Mar.
Artigo em Japonês | MEDLINE | ID: mdl-33762451

RESUMO

Pituitary adenomas are the most common cause of sellar masses although there are a number of other neoplastic, infectious, inflammatory, developmental, and vascular etiologies that should be considered. Pregnancy promotes a physiological increase in the size of the maternal pituitary gland, especially adenohypophysis. The normal maturation sequence of the pituitary gland apparently involves a period of physiological hypertrophy in teenagers. As most incidentalomas in pediatric patients are not associated with hormonal hypersecretion or hypopituitarism, and structural progression is not common, it is hypothesized that the extensive follow-up assessment recommended for adults might not be necessary for children. Patients presenting with a pituitary lesion should undergo a complete history and physical examination that includes evaluations for evidence of hypopituitarism and hormone hypersecretion syndrome. Patients with evidence for either of these conditions should undergo an appropriately directed biochemical evaluation. All patients presenting with a pituitary lesion abutting the optic nerves or chiasm on magnetic resonance imaging should undergo a formal visual field examination. Emergencies in pituitary disease can result from the failure of the pituitary gland to secrete one or more pituitary hormones or from neuro-ophthalmological symptoms due to the mass effect of an expanding hypothalamic-pituitary lesion. Early diagnosis and prompt treatment of endocrine emergencies are mandatory.


Assuntos
Adenoma , Hipopituitarismo , Neoplasias Hipofisárias , Adolescente , Adulto , Criança , Humanos , Hipertrofia , Hipopituitarismo/diagnóstico por imagem , Hipopituitarismo/etiologia , Imagem por Ressonância Magnética , Hipófise , Neoplasias Hipofisárias/diagnóstico por imagem
18.
Indian J Ophthalmol ; 69(4): 992-994, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33727476

RESUMO

COVID-19 is a respiratory virus, which has affected various organ systems as well. Here we report a neuro-ophthalmic presentation of pituitary apoplexy under the setting of COVID-19 infection in a middle-aged man who presented to ophthalmic emergency with sudden bilateral loss of vision along with a history of fever past 10 days. There was sluggishly reacting pupils and RT-PCR for COVID was positive. Imaging pointed the diagnosis as pituitary macroadenoma with apopexy. In view of pandemic situation, patient was given symptomatic treatment as per the protocols and stabilized. Vision also showed improvement to some extent and the patient is awaiting neurosurgery.


Assuntos
Adenoma/diagnóstico , Infecções Oculares Virais/diagnóstico , Apoplexia Hipofisária/diagnóstico , Neoplasias Hipofisárias/diagnóstico , Adenoma/tratamento farmacológico , Adenoma/virologia , Infecções Oculares Virais/tratamento farmacológico , Infecções Oculares Virais/virologia , Glucocorticoides/uso terapêutico , Humanos , Imagem por Ressonância Magnética , Masculino , Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade , Apoplexia Hipofisária/tratamento farmacológico , Apoplexia Hipofisária/virologia , Neoplasias Hipofisárias/tratamento farmacológico , Neoplasias Hipofisárias/virologia
19.
Zhonghua Nei Ke Za Zhi ; 60(4): 345-349, 2021 Apr 01.
Artigo em Chinês | MEDLINE | ID: mdl-33765704

RESUMO

Objective: To explore the clinical characteristics of patients with pituitary thyrotropin-secreting adenoma and evaluate the effect of preoperative short-acting octreotide treatment on hyperthyroidism. Methods: A retrospective analysis was performed in 40 patients with pituitary thyrotropin adenoma diagnosed in Beijing Tiantan Hospital from January 2008 to January 2018. The general data, laboratory examinations and imaging findings were reviewed and analyzed. The clinical effect of preoperative octreotide on hyperthyroidism was evaluated. Results: The age of onset year of the 40 patients (male: female = 24∶16) was (30.5±5.1) years. Among them, 35 patients (87.5%) were with macroadenoma. The most common symptoms were thyroid hypermetabolism syndrome, followed by headache, dizziness, visual field damage and hypogonadism. The thyroid function of 30 patients (75%) recovered to normal within 3-5 days after the octreotide treatment. The total effective rate of the octreotide was 90.0%. The level of free thyroxine (FT4) before treatment in patients with more than 10 times of effective cumulative dose was significantly higher than that in patients with less than 10 doses. Conclusions: Thyroid hypermetabolism syndrome and pituitary occupying effect are the most common clinical manifestations of thyrotropin-secreting adenoma. Preoperative octreotide treatment can effectively control hyperthyroidism. The level of FT4 is a crucial factor affecting the efficacy of octreotide.


Assuntos
Adenoma , Neoplasias Hipofisárias , Adenoma/tratamento farmacológico , Feminino , Humanos , Masculino , Octreotida/uso terapêutico , Neoplasias Hipofisárias/tratamento farmacológico , Estudos Retrospectivos , Tireotropina
20.
Artigo em Russo | MEDLINE | ID: mdl-33560625

RESUMO

The combination of intracranial tumors and asymptomatic brain aneurysms is an urgent problem, since it can significantly affect surgical intervention. Aneurysms are common in patients with meningioma, glioma and pituitary adenoma. According to certain authors, combination of aneurysms with pituitary adenomas is 7 times more common than with other tumors. In these cases, a comprehensive examination of the patient and decision-making on surgical strategy are required. This review is devoted to epidemiology, diagnosis and treatment of patients with a combination of pituitary adenomas and intracranial aneurysms detected intraoperatively or at the preoperative stage. The manuscript is illustrated by cases observed at the Burdenko Neurosurgery Center.


Assuntos
Adenoma , Aneurisma Intracraniano , Neoplasias Meníngeas , Neoplasias Hipofisárias , Adenoma/epidemiologia , Adenoma/cirurgia , Humanos , Aneurisma Intracraniano/epidemiologia , Aneurisma Intracraniano/cirurgia , Procedimentos Neurocirúrgicos , Neoplasias Hipofisárias/cirurgia
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