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1.
Yonsei Med J ; 61(9): 797-804, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32882764

RESUMO

PURPOSE: Climate and lifestyle changes increase an individual's susceptibility to various allergens and also the incidence of allergic diseases. We aimed to examine the changes in sensitization rate for aeroallergens over a 10-year period in Korean children. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 4493 children who visited the allergy clinic at a tertiary hospital in Korea for allergic rhinitis or asthma from January 2009 to December 2018. The serum specific immunoglobulin E (IgE) levels were measured to confirm the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed and tree pollen mixtures, as well as cat and dog dander through ImmunoCAP test. RESULTS: D. farinae was the most common sensitizing aeroallergen (45.9%) during the 10-year span. The sensitization rate for tree pollen mixture (p for trend <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for trend=0.025), and cat dander (p for trend=0.003) showed ascending trends during the 10-year study period. Furthermore, the sensitization rate for multiple allergens (≥2) in 2018 increased significantly compared to that in 2009 (p for trend=0.013). Compared with children without sensitization to D. farinae, those with sensitization to D. farinae showed higher sensitization rates to other aeroallergens (p for interaction <0.001). CONCLUSION: Children's sensitization rate to cat and dog dander and weed and tree pollen mixtures significantly increased during the 10-year period in Korea. Children with sensitization to D. farinae are likely to be sensitized to other aeroallergens as well.


Assuntos
Alérgenos/imunologia , Asma/imunologia , Hipersensibilidade/diagnóstico , Imunoglobulina E/sangue , Rinite Alérgica/imunologia , Alérgenos/efeitos adversos , Animais , Asma/diagnóstico , Asma/epidemiologia , Gatos , Criança , Dermatophagoides farinae , Cães , Feminino , Humanos , Hipersensibilidade/imunologia , Masculino , Pólen/imunologia , República da Coreia/epidemiologia , Estudos Retrospectivos , Rinite Alérgica/diagnóstico
2.
Sci Total Environ ; 741: 140404, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-32887011

RESUMO

Allergic rhinitis caused by pollen exposure is one of the most common allergic diseases. Therefore monitoring pollen levels in ambient air is an important tool in research and health care. Most European monitoring stations collect airborne pollen at rooftop levels for measurements in the larger surrounding of the sampling station, and not in the direct environment of sensitized subjects. Here we present the development and evaluation of a portable pollen sampler, called "Pollensniffer", that was designed to collect pollen in the immediate environment of allergic subjects. Validation of the Pollensniffer against the standard volumetric pollen sampler showed for most pollen types high correlations between the number of pollen collected by those two devices (Spearman's Correlation Coefficient > 0.8); the Pollensniffer appeared to collect on average 5.8 times more pollen per hour than the static sampler. Pollen monitoring was performed using this Pollensniffer at street level at 3 different locations in the city of Leiden during 22 weeks in 2017 and 21 weeks in 2018, during three 15-min periods a day and at one day in the week. The results showed that the pollen levels for birch and grass pollen can significantly differ from location to location and per time of day. Furthermore, the Pollensniffer measurements at street level showed that birch and grass pollen grains were detected 1 1/2 and 2-3 weeks, respectively, before detection at rooftop level. The street measurements show that allergic subjects can encounter varying pollen levels throughout the city and that they can be exposed to grass and birch pollen and may experience hay fever symptoms, even before the sampler at rooftop level registers these pollen.


Assuntos
Alérgenos , Rinite Alérgica Sazonal , Betula , Cidades , Humanos , Pólen/imunologia
3.
Rev Prat ; 70(4): 453-459, 2020 Apr.
Artigo em Francês | MEDLINE | ID: mdl-32877109

RESUMO

The child and his allergenic environment. Environment's allergens may promote sensitization and after that generate symptoms (allergy). Allergic diseases are frequent in childhood and food allergy increase. Environmental factors may be aeroallergens but also food allergens. The first step of the therapeutic possibilities is to avoid the allergens, with lifestyle modifications. Emergency plan is necessary for school. A first prevention level is feasible and probably useful for food allergy, but not for respiratory allergy.


Assuntos
Alérgenos , Hipersensibilidade Alimentar , Criança , Família , Humanos
4.
S Afr Med J ; 110(7): 686-690, 2020 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-32880348

RESUMO

BACKGROUND: Allergy is a common health problem in South Africa (SA), and a rational approach to allergy testing is essential to ensure cost-effective as well as optimal patient diagnosis and management. OBJECTIVES: To review allergy testing data with respect to current national testing recommendations, and to explore the regional variations in sensitisation. METHODS: Retrospective data review on allergy testing from a private pathology provider in SA over a 2-year period. Data on skin-prick testing (SPT) and allergen-specific IgE testing originating from all the provinces of SA were collected and analysed with regards to allergen positivity rate and regional sensitisation patterns. RESULTS: Among the patients (N=45 0320) tested for a suspected inhalant allergy, 46% tested positive. Only 45% of these received additional testing for the nine recommended inhalant allergens included in the current national testing protocol. Among the patients (N=6 775) who received SPT for a suspected inhalant allergy, 59% yielded one or more positive results. The most frequent sensitising allergens were house dust mite (Dermatophagoides pteronyssinus) and grass pollen. The house dust mite, Blomia tropicalis, was a significant sensitiser in coastal regions. SPT identified two other important regional allergens which are not included in the current recommendations for inhalant allergen-specific IgE testing. CONCLUSIONS: The current diagnostic recommendations include allergens that demonstrate significant sensitisation in all regions of SA. Two additional allergens that show significant regional sensitisation in the South African population were identified. These findings may aid the recommendations for the most appropriate and cost-effective approach to allergy testing of symptomatic patients in SA.


Assuntos
Hipersensibilidade/epidemiologia , Alérgenos/imunologia , Animais , Humanos , Imunoglobulina E/sangue , Pólen/imunologia , Pyroglyphidae/imunologia , Estudos Retrospectivos , Testes Cutâneos , África do Sul/epidemiologia
5.
Lancet ; 396(10253): 753-754, 2020 09 12.
Artigo em Inglês | MEDLINE | ID: mdl-32919503
7.
BMC Infect Dis ; 20(1): 685, 2020 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-32948127

RESUMO

BACKGROUND: Recombinant fusion protein ESAT6-CFP10 (EC) is a newly developed skin test reagent for detecting Mycobacterium tuberculosis (M. tuberculosis) infection. In this study, we evaluated whether induration and erythema could be used as diagnostic indicators for EC skin test to detect M. tuberculosis infection. METHODS: A total of 743 tuberculosis patients and 1514 healthy volunteers underwent an EC skin test. The diameters of induration and erythema were measured with Vernier caliper, 24 h, 48 h, and 72 h after skin testing. Related indicators of EC reagent diagnostic test were tested, and the diagnostic effects of the four diagnostic indicators for EC skin test were compared. RESULTS: The sensitivity of induration / erythema measurement was lower at 24 h after EC skin test than at 48 h or 72 h (P<0.01). There was no difference in consistency (P = 0.16) between induration with clinical diagnosis, and erythema with clinical diagnosis at 48 h (88.88 and 90.16%, Kappa value was 0.75 and 0.78, respectively). In patients, the sensitivity of erythema measurement was higher than induration measurement (P<0.01). In healthy volunteers, the specificity of erythema measurement was lower than induration at 24 h after skin test, but there was no difference at 48 h after skin test (P = 0.22). In BCG vaccination volunteers, the specificity of induration and erythema were higher than 90%. In addition, there was a high consistency of induration and erythema. When induration or erythema was used as a positive diagnostic indicator, the sensitivity of the EC skin test was improved, and was no different from the other three indicators in terms of specificity and consistency with clinical diagnosis. CONCLUSIONS: Induration or erythema diameter not less than 5 mm could be used as a diagnostic indicator for detecting M. tuberculosis infection. TRIAL REGISTRATION: Phase III clinical trial of recombinant Mycobacterium tuberculosis ESAT6-CFP10 allergen; CTR20150695 ; registered in December 16, 2015.


Assuntos
Proteínas Recombinantes de Fusão , Teste Tuberculínico/métodos , Tuberculose/diagnóstico , Adulto , Alérgenos , Eritema/etiologia , Eritema/patologia , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/patogenicidade , Sensibilidade e Especificidade , Fatores de Tempo , Teste Tuberculínico/efeitos adversos , Tuberculose/microbiologia , Adulto Jovem
8.
Curr Allergy Asthma Rep ; 20(11): 68, 2020 09 05.
Artigo em Inglês | MEDLINE | ID: mdl-32889648

RESUMO

PURPOSE OF THE REVIEW: We provide a systematic review of experimental and clinical evidences linking allergy to acute, including common cold, and chronic rhinosinusitis in children. Furthermore, we questioned if anti-allergy treatment may prevent the occurrence of rhinosinusitis or improve outcomes of its specific management. RECENT FINDINGS: Allergic rhinitis is a common childhood disease in industrialized countries that is responsible for a major impact on quality of life and healthcare resources. Over the years many authors tried to correlate allergy with comorbidities and in particular to the onset of rhinosinusitis including common cold, even though conflicting results are frequently reached. We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process. Our search yielded 7103 that were finally screened. This resulted in 25 publications of which the full texts were assessed and included in a qualitative analysis per different phenotypes of rhinosinusitis. The evidence suggests that allergy may lead to overall impairment of mechanical and immunological defense function of the nasal mucosa against viruses and that anti-allergy treatment may significantly decrease the number and severity of upper respiratory tract infections including common colds in children. It was not possible to perform the analysis for allergy and post-viral acute rhinosinusitis, bacterial acute rhinosinusitis, and recurrent acute rhinosinusitis because of paucity and heterogeneity of data. Although there is no definitive proof of causation linking allergy to chronic rhinosinusitis, studies lead to suppose that anti-allergy treatment may improve outcomes of specific CRS treatments.


Assuntos
Antagonistas dos Receptores Histamínicos/uso terapêutico , Rinite Alérgica/complicações , Rinite Alérgica/tratamento farmacológico , Rinite/etiologia , Sinusite/etiologia , Doença Aguda , Alérgenos/imunologia , Biomarcadores/sangue , Criança , Doença Crônica , Humanos , Rinite Alérgica/sangue
9.
Rev Alerg Mex ; 67(2): 199-201, 2020.
Artigo em Espanhol | MEDLINE | ID: mdl-32892535
10.
Sci Total Environ ; 737: 140263, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-32783854

RESUMO

BACKGROUND: In epidemic thunderstorm asthma (ETSA) events a large number of people develop asthma symptoms over a short period of time. This is thought to occur because of a unique combination of high amounts of pollen and certain meteorological conditions. However, the exact cause and mechanism of epidemic thunderstorm asthma remains unclear. OBJECTIVES: The objective of this study was to test the hypothesis that convergence lines may be a causative factor in ETSA events, by investigating whether convergence line weather events are associated with the occurrence of high asthma presentations days during the Victorian grass pollen season (October-December). METHODS: A case control method was used. All public hospitals within 75 km of the Melbourne weather radar were included, and data were taken from 2009 to 2017 during the Victorian grass pollen season. Cases hospital days were hospitals with a high number of asthma presentations within a 24-h period, and controls were hospitals with an expected number of asthma presentations. Exposure was defined as geographical proximity of a convergence line to the hospital case or control. RESULTS: Eighty-one case hospital days and 157 hospital day controls were included in the study. The odds of exposure to a convergence line were significantly higher for cases than for controls at all exposure distances. At 4 km, 80 of the 81 cases had been exposed to a convergence line. CONCLUSION: Convergence lines appear to be a necessary, but not sufficient, element in the cause of epidemic thunderstorm asthma. This is the first study to show a clear link between epidemic thunderstorm asthma and convergence lines.


Assuntos
Alérgenos , Asma , Austrália , Estudos de Casos e Controles , Humanos , Pólen/imunologia , Tempo (Meteorologia)
11.
Medicine (Baltimore) ; 99(30): e21255, 2020 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-32791702

RESUMO

Atopic dermatitis (AD) is a common chronic relapsing inflammatory skin disease associated with a personal or family history of atopic diseases. Determining the objective severity scoring of AD index (SCORAD) and total immunoglobulin E (IgE) to help to stage the severity (lesions extent and intensity of the lesions and then the itch and sleep disturbance they may cause) of AD in children.In this study, we adopted the SCORAD index, which consists of severity, area, and sleep disturbance, to evaluate the AD status of children up to 18 years old. We examined the blood levels of total serum IgE, white blood cell count/differential count (WBC/DC), eosinophil counts (EC), eosinophil cationic protein (ECP) and specific IgE.A total of 208 children with AD were enrolled in this study. Serum IgE values and a number of specific IgE that are positive significantly different SCORAD index through simple linear regression; however, after multiple linear regression, only IgE values (95% CI: 0.001-0.004, P < .001), total WBC count (95% CI: 0.112-1.736, P = .026), EC (95% CI: 0.045-6.706, P = .047), and specific IgE to Cheddar cheese (95% CI: 1.814-16.731, P = .015) remain different. After applying the Phi coefficient, we found that specific IgE to tuna (r = 0.632), codfish (r = 0.613), and clam (r = 0.613) each had a moderate correlation with specific IgE to Cheddar cheese. The 6 most common allergens were found to be mite (D. Farinae: 65.9%), mite (D. Pterony: 64.9%), house dust (47.6%), cockroach mix (37.0%), shrimp (30.8%), and crab (22.6%). Covariates of SCORAD index, severity, area, and sleep disturbance differed.In this study, we found that total IgE values, specific IgE values, WBC, EC, and specific IgE to Cheddar cheese have significant correlations with SCORAD index in AD of Taiwanese children.


Assuntos
Dermatite Atópica/sangue , Hipersensibilidade Alimentar/sangue , Imunoglobulina E/sangue , Alérgenos/sangue , Biomarcadores/sangue , Queijo/efeitos adversos , Criança , Pré-Escolar , Dermatite Atópica/etiologia , Hipersensibilidade Alimentar/complicações , Humanos , Lactente , Contagem de Leucócitos , Índice de Gravidade de Doença , Taiwan
12.
Artigo em Chinês | MEDLINE | ID: mdl-32791635

RESUMO

Objective:To observe the safety of omalizumab and glucocorticoid in the dose-increasing phase of rush allergen immunotherapy(RIT). Method:The clinical data of 88 patients with allergic rhinitis treated with RIT were retrospectively studied, including gender, age, pre-treatment total VAS score, blood EOS%, serum total IgE, local and systemic adverse reactions. Of all patients, fifty-seven were treated with omalizumab combined with RIT(experimental group) and thirty-one were treated with hormone/antiallergic drugs combined with RIT(control group). The safety of the two groups was compared in the dose-increasing phase. Result:There was no grade Ⅰ systemic adverse reactions during the whole process in the experimental group, while Grade Ⅱ systemic adverse reactions were 4 cases(7.1%) during the period of hospitalization, 2 cases(3.6%) after the first injection after discharge, zero(0) after the second injection after discharge. No local pruritus and induration were observed. During the period of hospitalization, the first and second injection after discharge, control group had grade Ⅰ level systemic adverse reactions were 1 case(3.4%), 2 cases(6.9%), 1 case(3.4%) at different time point, respectively. Grade Ⅱ systemic adverse reactions were 5 cases(17.2%), 1 case(3.4%), zero(0) at different time point, respectively. Local injection site itching was observed in 8 patients(5 cases were mild and 3 cases were moderate) and 4 cases(13.8%) had induration during hospitalization. Conclusion:Omalizumab combined with RIT not only shortens the duration of dose-increasing phase of specific immunotherapy, but also increases the safety of the dose-increasing phase during hospitalization, the first and second injection after discharge and improves patient compliance.


Assuntos
Glucocorticoides , Rinite Alérgica , Alérgenos , Dessensibilização Imunológica , Humanos , Imunoterapia , Omalizumab , Estudos Retrospectivos
13.
Artigo em Chinês | MEDLINE | ID: mdl-32842222

RESUMO

Objective:To investigate the distribution of allergens in patients with allergic rhinitis(AR) in Rikaze. Method:A retrospective analysis was performed in patients with AR diagnosed by skin prick test (SPT) between June 2017 and June 2018 from Rikaze People's Hospital. Result:One hundred and thirty-one patients were diagnosed with AR using SPT. The most common inhalant allergens were pollen, including Artemisia sieversiana willd(64.8%), Artemisia annua L. (64.1%) and Humulus Scandens(45.8%), while soybean(17.6%), mango(15.3%) and carp(12.2%) were the most common food allergens. Conclusion:The most common inhalant allergens in patients with AR is the pollen in Rikaze area.


Assuntos
Alérgenos , Rinite Alérgica , Humanos , Pólen/imunologia , Estudos Retrospectivos , Testes Cutâneos
14.
J Chromatogr A ; 1627: 461396, 2020 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-32823101

RESUMO

Comprehensive two-dimensional gas chromatography (GC×GC) based on flow-modulation (FM) is gaining increasing attention as an alternative to thermal modulation (TM), the recognized GC×GC benchmark, thanks to its lower operational cost and rugged performance. An accessible, rational procedure to perform method translation between the two platforms would be highly valuable to facilitate compatibility and consequently extend the flexibility and applicability of GC×GC. To enable an effective transfer, the methodology needs to ensure preservation of the elution pattern, separation power, and sensitivity. Here, a loop-type thermal modulation system with dual detection (TM-GC×GC-MS/FID) used for the targeted analysis of allergens in fragrances is selected as reference method. Initially, six different columns configurations are systematically evaluated for the flow-modulated counterpart. The set-up providing the most consistent chromatographic separation (20 m x 0.18 mm dc x 0.18 µm df + 1.8 m x 0.18 mm dc x 0.18 µm df) is further evaluated to assess its overall performance in terms of sensitivity, linearity, accuracy, and pattern reliability. The experimental results convincingly show that the method translation procedure is effective and allows successful transfer of the target template metadata. Additionally, the FM-GC×GC-MS/FID system is suitable for challenging applications such as the quantitative profiling of complex fragrance materials.


Assuntos
Cromatografia Gasosa/métodos , Alérgenos/análise , Calibragem , Cromatografia Gasosa/normas , Ionização de Chama , Limite de Detecção , Perfumes/análise , Perfumes/normas , Reprodutibilidade dos Testes
18.
Environ Monit Assess ; 192(8): 537, 2020 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-32696086

RESUMO

A thunderstorm is a risk factor for severe respiratory allergy or asthma attacks in patients suffering from pollen/spore allergy. This study aimed to investigate the changes in the spectrum and quantity of pollen and fungal spores in the air of Bratislava during summer storms as well as the impact of selected environmental parameters on these changes. Pollen/spore samples were collected using a Burkard volumetric aerospore trap during summer 2016. To identify those types of pollen/spores that may harm human health during the storm episodes, we analysed how the concentration of individual bioparticles in the air changed during pre-storm/storm/post-storm periods. The effect of environmental variables on the concentration of selected pollen/spore types was evaluated through Spearman's correlation analysis. The results of our study suggest that thunderstorm-related respiratory allergy symptoms in the study area may be caused by (1) spores of Myxomycetes, the airborne concentration of which increases due to an increase in wind speed during the pre-storm period; (2) ruptured pollen and Diatripaceae spores, the concentration of which increases due to increase in precipitation and relative air humidity, respectively, during the storm period; and (3) spores of Fusarium and Leptosphaeria, the concentration of which increases due to increase in precipitation and air temperature, respectively, during the post-storm period.


Assuntos
Microbiologia do Ar , Poluentes Atmosféricos/análise , Alérgenos/análise , Monitoramento Ambiental , Europa (Continente) , Humanos , Estações do Ano , Esporos Fúngicos
19.
Wei Sheng Yan Jiu ; 49(3): 463-466, 2020 May.
Artigo em Chinês | MEDLINE | ID: mdl-32693898

RESUMO

OBJECTIVE: To investigate the potential allergenicity of oryza sativa recombinant human serum albumin(OsrHSA)in BALB/c mice. METHODS: Eighty BALB/c mice were randomly divided into four groups i. e ovalbumin(OVA) positive control group, potato acid phosphatase(PAP) negative control group, Oryza sativa recombinant HAS(OsrHSA) group and solvent control group(phosphate buffer saline, PBS), respectively. Mice were administered by intraperitoneal injections of tested proteins and histamine levels in plasma and sIgE, sIgG, sIgG1, sIgG2 a, and tIgE antibody levels in serum were measured. RESULTS: Compared with the other groups, serum tIgE, sIgE, sIgG, sIgG1 and plasma histamine levels in the OVA group were significantly increased, while serum sIgG2 a levels were decreased(P<0. 05). There was no significant difference in serum sIgE level and histamine level between the OsrHSA group and the control group(P>0. 05). Serum sIgG, sIgG1 and sIgG2 a levels were lower than those in the PAP group(P<0. 05). There was no significant difference in serum tIgE content between PAP group and OsrHSA group(P>0. 05). CONCLUSION: The potential allergenicity of OsrHSA through traperitioneal injection in BALB/c mice was very low.


Assuntos
Oryza , Alérgenos , Animais , Humanos , Camundongos , Camundongos Endogâmicos BALB C , Ovalbumina , Albumina Sérica Humana
20.
J Environ Sci (China) ; 95: 43-48, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32653191

RESUMO

Pollen pollution and allergy are becoming prominent issues in China. However, few studies on pollinosis have been reported. As an allergen in the atmosphere, allergenic Humulus scandens pollen was collected from four districts of Shanghai, including Wusong (WS), Jiading (JD), Xujiahui (XJH) and Songjiang (SJ). The mass concentrations of SO2, NO2, O3, PM10, and PM2.5 (particulate matter with air dynamic diameter less than 10 and 2.5 µm, respectively) near the four sampling sites were also recorded during Humulus scandens pollen season. The allergenicity of the Humulus scandens pollen was assessed by using of a rat model and enzyme linked immunosorbent assay (ELISA). Relationships between the allergenicity and air pollutants were correlated. Our results demonstrated that the biological viability of the pollens collected from the four districts exhibited no significant differences. ELISA and dot blotting results further demonstrated that the serum of sensitized rats exhibited much higher immune-reactive response than that of control groups. Western blotting showed that the 15 KD (1KD = 1000 dalton) proteins of Humulus pollen led to the allergic response. The allergenic intensity of Humulus pollen protein from different samples followed the pattern: WS > JD > XJ > SJ. There was a negative relationship between the allergenicity of Humulus pollens and PM10 (R = -0.99) / PM2.5 (R = -0.73), and a positive relationship with O3 (R = 0.92). These data clearly showed that PM10 and PM2.5 could enhance Humulus pollen protein release, and O3 could aggravate the allergenicity of the Humulus pollen.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/análise , Humulus/imunologia , Alérgenos/análise , Animais , China , Material Particulado/análise , Pólen/química , Pólen/imunologia , Ratos
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