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2.
Hautarzt ; 71(3): 174-181, 2020 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-31965202

RESUMO

BACKGROUND: While the pathogenesis of contact allergy in recent years has increasingly focused on the mechanisms of the innate immune response, valid therapeutic options are still lacking. AIMS: This article intends to shed light on the background of contact allergy development as well as possible risk factors and to highlight potential new therapeutic options. MATERIALS AND METHODS: Allergic contact dermatitis (ACD) as well as the sensitization and trigger phase, potential risk factors as well as the therapy options including (current) PubMed-listed literature are described. RESULTS: Inflammation plays a central role in ACD. The innate immune system responds to contact allergens as well as to infection. Elucidation of the mechanisms will enable a targeted therapeutic intervention in the future. CONCLUSION: Although there is still a need for research, many parts of the contact allergy pathogenesis are now better understood. In particular, the essential role of the innate immune response not only for the sensitization but also for the elicitation phase seems to be established. Implementation of today's knowledge into new therapeutic approaches and their application testing remains important and exciting.


Assuntos
Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/patologia , Dermatite Alérgica de Contato/terapia , Humanos , Imunidade Inata , Inflamação
3.
Hautarzt ; 71(3): 205-210, 2020 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-31965206

RESUMO

The design and development of insulin pumps and various glucose sensor systems has an enormous impact on life quality of diabetic patients. Surveillance and therapy of diabetes has improved due to the new diabetic devices, which are affixed to the patients' skin for several days. Since their introduction, irritant and allergic contact dermatitis have been frequently reported. Patients often acquire contact sensitization to isobornyl acrylate, N,N-dimethylacrylamide or formerly to 2­ethyl-cyanoacrylate. These contact allergens were found in the patch, in the glue to affix the box on the patch or in the casing of the system itself. Development of contact allergy to substances of these systems may result in the need to abandon modern diabetic devices.


Assuntos
Adesivos/efeitos adversos , Alérgenos/efeitos adversos , Automonitorização da Glicemia/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Inflamação/etiologia , Sistemas de Infusão de Insulina/efeitos adversos , Testes do Emplastro/métodos , Acetatos , Automonitorização da Glicemia/instrumentação , Compostos Bicíclicos com Pontes , Dermatite Alérgica de Contato/prevenção & controle , Diabetes Mellitus , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 1/tratamento farmacológico , Reação a Corpo Estranho/etiologia , Glucose , Humanos , Insulinas/administração & dosagem , Insulinas/uso terapêutico
4.
Hautarzt ; 71(3): 197-204, 2020 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-31965209

RESUMO

BACKGROUND: Fragrances are regarded as the most common contact allergens after nickel. In this context, the frequency of positive patch test reactions to fragrance mix is often presented as proof. According to EU regulation No. 1223/2009, 26 fragrances that are regarded as significant allergens have to be declared on cosmetic products. OBJECTIVES: The frequency of patch test reactions to fragrances and differentiation between frequently and rarely sensitizing fragrances were evaluated. MATERIALS AND METHODS: Data from the Information Network of Departments of Dermatology (IVDK), mostly of the years 2016-2018, were retrospectively analyzed. RESULTS: Frequency of positive reactions to fragrance mix I in the departments of dermatology joining the IVDK reached a historical low of 5.4% in 2018. Since 2013, positive reactions to fragrance mix II have been declining, yielding 3.2% in 2018. Of fragrance mix I, the allergen with the most positive test reactions is no longer oakmoss absolute, but isoeugenol. In fragrance mix II, hydroxyisohexyl 3­cyclohexene carboxaldehyde (HICC) is still leading. Only 11 of the 26 fragrances subject to mandatory declaration elicited allergic test reactions in more than 1% of the patients tested. DISCUSSION: The decline of positive test reactions to the fragrance mixes is mainly due to the reduced use of oakmoss containing atranol and chloroatranol, and HICC. Use of these substances in cosmetic products was prohibited within the EU starting in August 2019. Therefore, a further decline of the sensitization frequencies can be expected. A differentiated consideration of the individual fragrances under allergological aspects is urgently required.


Assuntos
Dermatite Alérgica de Contato/diagnóstico , Odorantes , Perfumes/efeitos adversos , Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Humanos , Testes do Emplastro , Estudos Retrospectivos
5.
Hautarzt ; 71(3): 182-189, 2020 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-31950209

RESUMO

BACKGROUND: In the case of a contact allergy, there is only allergen avoidance instead of causal therapy. If the allergen is not identified, dermatitis persists, which is a major burden for patients. Patch testing is the diagnostic standard for detecting contact sensitization. Based on a systematic literature search, the German patch test guideline was updated and methodologically upgraded. OBJECTIVES: The most important practical aspects of patch testing with contact allergens and drugs are presented. MATERIALS AND METHODS: Current consensus guidelines for performing patch tests as well as the results of a supplementary selective literature search are summarized. RESULTS: According to the patch test guideline (AWMF registry no. 013-018, 2019), the baseline series, special series and, if necessary, test preparations prepared from the patient's own contact substances should be tested routinely. A new evidence-based recommendation is a late reading after 7-10 days, as otherwise numerous patch test reactions will be missed. Antihistamines may weaken the cellular reactions of the patch test and should be discontinued with a latency of 5 half-lives. Finally, if a false-negative patch test result is suspected, it is recommended to perform a strip patch test according to the validated protocol. CONCLUSIONS: All patients with a suspected contact allergy should receive a guideline-based patch test at an early stage. Targeted patch testing identifies clinically relevant allergens and provides suggestions for further systematic investigations.


Assuntos
Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Guias de Prática Clínica como Assunto , Humanos , Testes do Emplastro , Sistema de Registros
6.
Hautarzt ; 70(12): 948-952, 2019 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-31754739

RESUMO

Resorcinol is a frequently used hair dye, whose quantitative risk assessment (QRA) for hair color products is presented in this review as an example to assess its skin sensitization risk after topical application. Its purpose is to determine the maximum concentration that can be used without expecting skin sensitization to occur. The focus is to prevent the de novo development of a contact allergy. Epidemiological data which are provided via dermatological surveillance, e.g., by the IVDK (Information Network of Departments of Dermatology) in Germany, are an important source of information that help to assess the quality and the effectivity of the QRA.


Assuntos
Alérgenos , Dermatite Alérgica de Contato , Resorcinóis , Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/prevenção & controle , Alemanha , Humanos , Testes do Emplastro , Resorcinóis/efeitos adversos , Medição de Risco , Pele
7.
Tidsskr Nor Laegeforen ; 139(12)2019 Sep 10.
Artigo em Norueguês, Inglês | MEDLINE | ID: mdl-31502777

RESUMO

BACKGROUND: The hospital departments for occupational medicine and the National Institute of Occupational Health (STAMI) established a shared, anonymous patient register in 2009. This report describes the diagnoses, occupations and exposure factors that occur most frequently in the youngest patient group. This will reflect exposures in modern working life in particular, and thus produce important knowledge with regard to targeted prevention efforts. MATERIAL AND METHOD: We have undertaken a descriptive analysis of 910 examinations of patients in the age group 20-29 years, performed in occupational medicine departments in Norway during the period 2010-17. RESULTS: Examinations of patients aged 20-29 years accounted for 914 (8 %) of a total of 11 969 recorded patient examinations. We excluded four participants for whom information on their sex was missing. This age group encompassed 498 (55 %) men, compared to 75 % men in the total dataset. The most frequent diagnoses were asthma (187/910, 21 %), contact eczema (184/910, 20 %) and rhinitis (73/910, 8 %). The most frequent exposure factors were irritants/allergens (469/910, 52 %). The most common occupations were hairdresser (159/910, 17 %) and painter/varnisher (46/910, 5 %). Hairdresser was the predominant occupation among women (154/412, 37 %), while painter/varnisher (35/498, 7 %) and electrician (25/498, 5 %) predominated among men. INTERPRETATION: Young patients who are examined in occupational medicine departments in Norway are most frequently registered with asthma or hand eczema. Hairdressers are especially exposed, indicating a special need for primary prevention in this occupation to prevent development of illness. In cases of asthma and hand eczema, doctors should be aware of the possibility that this might be occupationally related.


Assuntos
Doenças Profissionais/epidemiologia , Adulto , Alérgenos/efeitos adversos , Asma Ocupacional/epidemiologia , Barbearia , Dermatite de Contato/epidemiologia , Traumatismos por Eletricidade/epidemiologia , Feminino , Humanos , Irritantes/efeitos adversos , Masculino , Noruega/epidemiologia , Exposição Ocupacional/efeitos adversos , Medicina do Trabalho , Pintura/efeitos adversos , Sistema de Registros , Rinite/epidemiologia , Adulto Jovem
8.
Hautarzt ; 70(10): 778-789, 2019 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-31506756

RESUMO

The head and hands are the two most common locations for allergic contact dermatitis manifestation. In hand eczema, contact with a contact allergen is a frequent (co-)factor in the triggering and maintenance of eczema. For all hand eczemas lasting longer than 3 months, an allergological examination by means of patch testing is recommended. In patients with allergic contact dermatitis of the hands, nickel, MCI/MI, fragrance mix I, cobalt, thiuram mix, Balsam of Peru, chromium and fragrance mix II have been described in a multicenter European study as the most common contact allergens of the standard series. In the information network of dermatological clinics (IVDK) a total of 56,170 patients were patch-tested in the years 2014 to 2018. In all, 16,807 of these patients (29.9%) suffered from hand eczema, of which 7725 (46.0%) had occupational dermatosis (OD) and 6820 (40.6%) had no OD. For the remaining patients this was unknown. The top 30-list of allergens in hand eczema patients without and with OD included 22 common contact allergens, but with different reaction frequency. In hand eczema patients without OD, the following contact allergens also belong to this list: octyl gallate, sorbic acid, tert-butylhydroquinone, propylene glycol, mercury (II) amide chloride, tolubalsam, jasmine absolute, and sandalwood oil. For hand eczema patients with OD, these are instead: tetramethylthiurammonosulfide, tetramethylthiuramdisulfide, 1,3-diphenylguanidine, p­phenylenediamine, p­toluylenediamine, iodopropinylbutylcarbamate, glutaraldehyde, and monoethanolamine. In the case of OD of the hands, early involvement of the responsible statutory accident insurance by initiating the dermatologist procedure ("Hautarztverfahren") is necessary in order to work together towards successful allergen avoidance by means of substitution and optimizing personal protective equiment.


Assuntos
Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Eczema/induzido quimicamente , Dermatoses da Mão/induzido quimicamente , Testes do Emplastro/métodos , Dermatite Ocupacional , Eczema/diagnóstico , Dermatoses da Mão/diagnóstico , Humanos
9.
Am J Chin Med ; 47(5): 1099-1112, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31366207

RESUMO

Asthma is the most prevalent chronic respiratory disease worldwide. Garlic extracts have long been used as a food source and in traditional medicine. Crude extracts of garlic are used as an anti-inflammatory agent and have been reported to exhibit antiasthmatic properties. However, molecular mechanisms of garlic extracts in the context of antiasthmatic airway inflammation are still unclear. In this study, the antiasthmatic effect of garlic extracts on Th1, Th2, and Th3 cytokine profiles and immunoregulatory mechanism were explored using an animal model of allergic asthma. Garlic extracts significantly reduced total inflammatory cell counts and eosinophil infiltration and decreased the production of Dermatophagoides pteronyssinus IgE in serum and Th1/Th2/Th3 cytokine in bronchoalveolar fluid. Enzyme-linked immunosorbent assay analysis demonstrated that garlic extracts downregulated the levels of cytokines and chemokines, namely Th2-related IL-4, IL-5, and IL-13; but they simultaneously upregulated Th1-related IFN-γ, IL-12, and Th3-related IL-10 and TGF-ß expression in BALF. The mechanism may be ascribed to the modulation of Th1-, Th2-, and Th3-related cytokine imbalance.


Assuntos
Asma/prevenção & controle , Alho/química , Extratos Vegetais/administração & dosagem , Substâncias Protetoras/administração & dosagem , Alérgenos/efeitos adversos , Animais , Anti-Inflamatórios/administração & dosagem , Asma/induzido quimicamente , Asma/genética , Asma/imunologia , Feminino , Humanos , Imunoglobulina E/imunologia , Interleucina-12/genética , Interleucina-12/imunologia , Interleucina-5/genética , Interleucina-5/imunologia , Camundongos , Camundongos Endogâmicos BALB C , Células Th1/efeitos dos fármacos , Células Th1/imunologia , Células Th2/efeitos dos fármacos , Células Th2/imunologia
10.
Anticancer Res ; 39(8): 4511-4516, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31366553

RESUMO

BACKGROUND/AIM: Gluconacetobacter hansenii (G. hansenii) is an acetic acid bacterium of vinegar production. Its anti-allergic effect on mice upon oral administration was examined. MATERIALS AND METHODS: The amount of LPS was measured by the Limulus reaction. Mice were sensitized by peritoneal and intranasal administration of cedar pollen and alum followed by oral administration of 30 or 150 mg/kg of heated G. hansenii cells. Pollen was administered intranasally to evaluate nasal symptoms, and at 8 weeks, IgE and IL-10 levels in blood were measured by ELISA. RESULTS: The amount of LPS in dried bacterial cells was 10.4±3.3 mg/g. In the cedar pollinosis model of mice, a significant reduction was observed in nose scratching of both groups administered with the bacterial cells (30, 150 mg/kg). CONCLUSION: G. hansenii contains LPS, and its oral administration showed an anti-allergic effect by a significant mitigation of the symptoms in a pollen allergy mouse model.


Assuntos
Antialérgicos/administração & dosagem , Gluconacetobacter/imunologia , Pólen/efeitos adversos , Rinite Alérgica Sazonal/prevenção & controle , Ácido Acético/química , Administração Oral , Alérgenos/efeitos adversos , Animais , Antialérgicos/imunologia , Modelos Animais de Doenças , Humanos , Imunoglobulina E/imunologia , Camundongos , Rinite Alérgica Sazonal/microbiologia , Rinite Alérgica Sazonal/patologia
11.
Pediatr Clin North Am ; 66(5): 981-993, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31466686

RESUMO

Allergic rhinitis is a common disorder that regularly occurs in children and adolescents. The disease is associated with other allergic diseases, such as asthma, and it carries a heavy burden, with effects on sleep, school performance, and quality of life. Classic symptoms include sneezing, rhinorrhea, nasal obstruction, and nasal itching. When the eyes are involved, the term allergic rhinoconjunctivitis is used. Triggers may include airborne pollens, molds, dust mites, and animals. Skin or blood allergy testing can be a useful diagnostic modality that may guide therapy. Immunotherapy can prevent the development of further allergic sensitizations as well as subsequent asthma.


Assuntos
Rinite Alérgica/etiologia , Rinite Alérgica/terapia , Adolescente , Alérgenos/efeitos adversos , Alérgenos/imunologia , Criança , Humanos , Imunoterapia , Qualidade de Vida , Rinite Alérgica/imunologia , Rinite Alérgica/fisiopatologia , Fatores de Risco
13.
Zhonghua Jie He He Hu Xi Za Zhi ; 42(7): 515-521, 2019 Jul 12.
Artigo em Chinês | MEDLINE | ID: mdl-31365968

RESUMO

Objective: Eosinophil progenitor cells (EoP) play a critical role in allergic airway inflammation in asthma. Previous studies have revealed that the expression of IL-25 receptor subunits (IL-17RA and IL-17RB) are increased on eosinophils (Eos) from allergic asthmatics upon allergen inhalation but few study has explored the role of IL-25 on EoP. Thus, in this research we examined the possible role of IL-25 on EoP in allergic asthmatics challenged by allergen, as well as in animal models where we verified the changes of newly produced Eos after IL-25 knockout. Methods: Asthmatics (n=14, during 2017-2018) who developed allergen-induced early and late responses were enrolled in this study. Blood was collected at pre-and 24 h post-challenge. Surface expression of IL-17RA and IL-17RB were evaluated by flow cytometry on EoP. In vitro migration assay was used to examine migrational responses of EoP and hematopoietic cells (HPC) from these subjects. In animal models, mice were grouped according to whether IL-25 was knock-out and whether mice were sensitized and challenged by ovalbumin (OVA) into asthmatic, control, knockout asthmatic and knockout control groups. Lung tissues, bronchoalveolar lavage flow (BALF) and bone marrow tissues of these mice were collected in order to evaluate airway inflammation and amount of newly produced (Brdu positive) and mature Eos. Results: EoP expressing IL-17RB were significantly increased after allergen inhalation in allergic asthmatics [(514±138) vs. (1146±450)/10(6) cells, pre-and post-challenge, F=6.819, P=0.022]. Pre-exposure to IL-25 primed the migrational responsiveness of EoP to stromal cell-derived factor (SDF)1α [(39.0±10.1)% vs. (73.0±7.9)%, control and IL-25 exposure groups respectively, P=0.021, 95% CI 5.19%~58.45%]. In OVA sensitized mice, knockout of IL-25 significantly reduced Eos and newly produced Eos percentage in the BALF [Eos, (7.8±2.0)% vs. (3.1±0.6)%, asthmatic and knockout asthmatic group respectively, P=0.002, 95% CI-7.57% to -1.98%; Brdu positive Eos, (50.0±7.6)% vs. (8.6±4.3)%, asthmatic and knockout asthmatic group respectively, P=0.011, 95% CI-72.41% to -10.27%], and newly produced Eos were also reduced in the bone marrow [(70.8±6.1)% vs. (1.3±1.3)%, asthmatic and knockout asthmatic group respectively, P=0.000, 95% CI -94.88% to -44.18%]. Conclusion: These results suggest an important role of IL-25 in allergen-induced EoP migration, local differentiation and eosinophilia in the airways.


Assuntos
Alérgenos/efeitos adversos , Asma , Eosinófilos/imunologia , Animais , Líquido da Lavagem Broncoalveolar , Interleucinas , Camundongos , Camundongos Endogâmicos BALB C , Ovalbumina , Células-Tronco
14.
Dermatitis ; 30(4): 264-267, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31261221

RESUMO

BACKGROUND: Allergic contact dermatitis is an inflammatory condition that less commonly presents with scalp involvement. Recently, T regulatory cells have been documented to be residents of hair follicles, illuminating why contact allergens are less likely to elicit dermatitis in the scalp. OBJECTIVE: The aims of the study were to determine the prevalence of scalp symptoms, with and without other affected areas, in patients presenting for evaluation of allergic contact dermatitis and to determine the allergens most likely to be associated with scalp dermatitis. METHODS: We examined allergens commonly found in hair products and stratified positive patch test results by the following affected areas: face, eyelid, neck, or hands, where exposure by runoff is common, versus scalp. CONCLUSIONS: Para-phenylenediamine (PPD) is the most common allergen in patients with scalp dermatitis. The rate of PPD sensitization is higher in nonwhite compared with white patients. In the small number of patients with isolated scalp involvement, positive patch tests to PPD were documented in a minority. Other allergens found in hair products may present without scalp symptoms. Patients with dermatitis affecting areas other than the scalp should provide their hair product ingredients to guide patch test selection.


Assuntos
Dermatite Alérgica de Contato/etiologia , Tinturas para Cabelo/efeitos adversos , Fenilenodiaminas/efeitos adversos , Dermatoses do Couro Cabeludo/diagnóstico , Adulto , Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro/métodos , Dermatoses do Couro Cabeludo/etiologia
15.
Chemosphere ; 234: 277-286, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31220661

RESUMO

Particulate matter (PM) exposure increases the risk of asthma. However, the effect of PM2.5 exposure on liver metabolism in mice with asthma symptoms remains unclear. We established an ovalbumin (OVA)-induced asthma model in mice and divided the animals into four groups: control group (C), PM2.5 exposure group (P), OVA-induced asthma group (O) and OVA-induced asthma PM2.5 exposure group (OP). Gas chromatography-mass spectrometry (GC-MS) was used to identify the metabolite markers and related perturbed metabolic pathways in mouse liver tissue after PM2.5 exposure. Multivariate analysis showed 9 and 12 potential metabolite markers in the P and OP groups, respectively, after PM2.5 exposure that were significantly correlated with lipid peroxidation indices. PM2.5 exposure perturbed 5 and 7 metabolic pathways in the P and OP groups, respectively. These metabolic pathways mainly involve the lipid metabolism, amino acid metabolism, carbohydrate metabolism, and nucleotide metabolism. These results highlight the potential to study PM2.5-triggered alterations via liver tissue in normal and OVA-induced asthmatic mice to gain a more realistic appraisal of the resulting early toxicity events. Additionally, these results revealed potential metabolite markers of early antioxidant defense events triggered by PM2.5 and indicated that metabolite markers are more sensitive than antioxidant indicators.


Assuntos
Asma/metabolismo , Fígado/metabolismo , Material Particulado/toxicidade , Alérgenos/efeitos adversos , Animais , Antioxidantes/farmacologia , Asma/induzido quimicamente , Cromatografia Gasosa-Espectrometria de Massas/métodos , Masculino , Redes e Vias Metabólicas/imunologia , Camundongos , Ovalbumina/farmacologia , Material Particulado/imunologia
16.
Actas Dermosifiliogr ; 110(8): 666-672, 2019 Oct.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31208672

RESUMO

INTRODUCTION: Foot eczema is a common complaint encountered by skin allergists. OBJECTIVE: To study a series of patients with foot eczema who underwent patch testing and describe their demographic profile, diagnoses, and the main allergens involved. MATERIAL AND METHODS: Cross-sectional observational study of all patients tested with the standard Spanish patch test series at a dermatology department over a period of 13 years (2004-2016). We studied patch test results and definitive diagnoses by comparing different subgroups of patients with foot eczema. RESULTS: Of the 3,265 patients included in the study, 308 (9.4%) had foot eczema, 176 (57.9%) had foot eczema only and 132 (42.1%) had concomitant foot and hand eczema. Positive patch test results were more common in patients with foot eczema only (positivity rate of 61.5% vs. 53.4% for foot and hand eczema). In the subgroup of patients with concomitant foot and hand involvement, patients aged under 18 years had a lower rate of positive results (51.3% vs. 64.6% for patients >18 years). Potassium dichromate was the most common allergen with current relevance in all subgroups. The main diagnosis in patients with foot involvement only was allergic contact dermatitis (49.1%). In the subgroup of patients with concomitant hand and foot eczema, the main diagnoses were psoriasis in adults (33.6%) and atopic dermatitis in patients aged under 18 years (60.0%). CONCLUSION: Patch tests are a very useful diagnostic tool for patients with foot eczema with or without concomitant hand involvement.


Assuntos
Dermatite Alérgica de Contato/diagnóstico , Eczema/diagnóstico , Doenças do Pé/diagnóstico , Testes do Emplastro , Psoríase/diagnóstico , Adolescente , Adulto , Fatores Etários , Alérgenos/efeitos adversos , Alérgenos/análise , Corantes/efeitos adversos , Estudos Transversais , Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Eczema/induzido quimicamente , Eczema/epidemiologia , Feminino , Doenças do Pé/induzido quimicamente , Doenças do Pé/epidemiologia , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/epidemiologia , Humanos , Masculino , Testes do Emplastro/métodos , Dicromato de Potássio/efeitos adversos , Psoríase/epidemiologia , Estudos Retrospectivos , Fatores de Tempo , Adulto Jovem
17.
Sante Publique ; S1(HS): 35-42, 2019 May 13.
Artigo em Francês | MEDLINE | ID: mdl-31210489

RESUMO

OBJECTIVE: Many research papers have addressed the beneficial qualities of forests in promoting mental and physical health. However, we should also be clear that forest environments could have detrimental effects. Some of them, which are of allergic nature, have hitherto been largely neglected. METHODS: A comprehensive literature search has allowed us to achieve an initial synthesis on this matter. The emphasis was on temperate forests, especially on French forests. RESULTS: Anemophilous pollen from deciduous trees is the major factor causing respiratory allergies in connection with forests. The risks are focused between mid-winter and late spring. Ash, hornbeam and birch pollen and, more incidentally, oak and beech pollen induce allergic reactions not only in the forests, but also at great distances. As a result of its high humidity and because decaying organic matter is very abundant, the forest environment presents also a breeding ground for mould growth. Accordingly, fungal spores can lead to allergic manifestations recalling pollinosis. Lastly, the "other" allergies mainly include contact dermatitis symptoms, which affect wood workers first and foremost. However, the pine processionary moth, whose zone of infestation is rapidly spreading northwards and whose setae contain several relevant allergens, represents one particular case. CONCLUSION: Allergic reactions observed in forests or originating in forests are sufficiently frequent to justify to set up a wide-reaching system for aerobiological and epidemiological monitoring.


Assuntos
Alérgenos/efeitos adversos , Florestas , Hipersensibilidade , Pólen/efeitos adversos , Humanos , Estações do Ano
18.
Nutrients ; 11(6)2019 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-31197093

RESUMO

Cow's milk allergy (CMA) belongs to one of the most common food allergies in early childhood affecting 2-3% of children under 3 years of age. However, approximately 1% of adults remain allergic to cow's milk, often showing severe reactions even to traces of milk. In our study, we recruited patients with different clinical manifestations of CMA, including patients with anaphylaxis and less severe symptoms. We assessed the sensitization patterns and allergic responses of these subgroups through different immunological and cell-based methods. Sera of patients were investigated for IgE against whole cow's milk and its single allergens by CAP- FEIA. In a newly developed in-house multiplex dot assay and a basophil activation test (BAT), cow's milk allergens, in addition to human breast milk and single allergens from cow's and human milk were analyzed for IgE recognition and severity of CMA in the included patients. Both the CAP-FEIA routine diagnostic and the multiplex dot test could differentiate CMA with severe from milder allergic reactions by means of the patients' casein sensitization. The BAT, which mirrors the clinical response in vitro, confirmed that basophils from patients with severe reactions were more reactive to caseins in contrast to the basophils from more moderate CMA patients. By means of this improved component-resolved diagnosis of CMA, individual sensitization patterns could be assessed, also taking sensitization against human milk into consideration.


Assuntos
Alérgenos/imunologia , Hipersensibilidade a Leite/imunologia , Leite Humano/imunologia , Leite/imunologia , Alérgenos/efeitos adversos , Animais , Caseínas/efeitos adversos , Caseínas/imunologia , Bovinos , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Leite/efeitos adversos
19.
Medicina (Kaunas) ; 55(6)2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-31159395

RESUMO

Background and Objectives: Zea m 1 is a pollen allergen, which is present in maize, is accountable for a type I hypersensitivity reaction in all over the world. Several effective medications are available for the disorder with various side effects. Design and verification of a peptide-based vaccine is a state-of-art technology which is more cost effective than conventional drugs. Materials and Methods: Using immunoinformatic methods, the T cell epitopes from the whole structure of this allergenic protein can be predicted. Worldwide conserved region study among the other pollen allergens has been performed for T cell predicted epitopes by using a conservancy tool. This analysis will help to identify completely conserved HLA (human leukocyte antigen) binding epitopes. Lastly, molecular docking study and MHC-oligopeptide complex binding energy calculation data are applied to determine the interacting amino acids and the affinity of the epitopes to the class II MHCmolecule. Results: The study of criteria-based analysis predicts the presence of two epitopes YVADDGDIV and WRMDTAKAL on this pollen allergen. Conclusions: The T cell epitopes identified in this study provide insight into a peptide-based vaccine for a type I hypersensitivity reaction induced by Zea m 1 grass pollen allergenic protein.


Assuntos
Epitopos de Linfócito T/imunologia , Pólen/imunologia , Zea mays/efeitos adversos , Alérgenos/efeitos adversos , Humanos , Imunização , Pólen/efeitos adversos , Zea mays/imunologia
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