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3.
Can Bull Med Hist ; 17(1-2): 155-92, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14526803

RESUMO

In 1995, Canadian scientists Robert Noble and Charles Beer were inducted into the Canadian Medical Hall of Fame for their 1950s "discovery" of Vinblastine. Their "chance" finding of an anticancer drug in the leaves of the periwinkle plant (Vinca rosea, Linn.), is used to explore the historical issue of discovery, accidental discovery, and priority. The elements of the discovery are reconstructed through the oral testimony of key players and their published and unpublished records. Several "unsung heroes" played key roles in this project and reasons for their relative invisibility will be presented. Special attention is paid to the relationship between the small Canadian academic group working at UWO and the large pharmaceutical company (Eli Lilly) engaged in similar research at the same time.


Assuntos
Tratamento Farmacológico/história , Achados Incidentais , Neoplasias/história , Alcaloides de Vinca/história , Canadá , História do Século XX
4.
Biochem Cell Biol ; 68(12): 1344-51, 1990 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-2085431

RESUMO

In folklore medicine, extracts of the leaves of the subtropical plant Catharanthus roseus (L.) G. Don (sometimes known as Madagascar periwinkle) were reputed to be useful in the treatment of diabetes. This review describes how attempts to verify the antidiabetic properties of the extracts led instead to the discovery and isolation of two complex indole alkaloids, vinblastine and vincristine, which are used in the clinical treatment of a variety of cancers. The two alkaloids, although structurally almost identical, nevertheless differ markedly in the type of tumors that they affect and in their toxic properties. These and related alkaloids have been the subject of many pharmacological and biochemical investigations both in vivo and in vitro in the search for improved cancer treatments. A model system used in these studies, a transplantable lymphoma in Noble strain rats designated Nb2 node, has serendipitously led to the development of a highly sensitive and specific bioassay for lactogenic hormones.


Assuntos
Oncologia/história , Alcaloides de Vinca/história , Animais , Diabetes Mellitus Tipo 1/tratamento farmacológico , Ensaios de Seleção de Medicamentos Antitumorais , Feminino , História do Século XX , Hipoglicemiantes/história , Hipoglicemiantes/uso terapêutico , Jamaica , Linfoma/tratamento farmacológico , Linfoma/patologia , Masculino , Medicina Tradicional , Neoplasias/tratamento farmacológico , Ontário , Extratos Vegetais/uso terapêutico , Ratos , Células Tumorais Cultivadas/efeitos dos fármacos , Alcaloides de Vinca/isolamento & purificação , Alcaloides de Vinca/uso terapêutico
5.
Biochem Cell Biol ; 68(12): 1344-51, Dec. 1990.
Artigo em Inglês | MedCarib | ID: med-7862

RESUMO

In folklore medicine, extracts of the leaves of the subtropical plant Catharanthus roseus (L.) G. Don (sometimes known as Madagascar periwinkle) were reputed to be useful in the treatment of diabetes. This review describes how attempts to verify the antidiabetic properties of the extracts led instead to the discovery and isolation of two complex indole alkaloids, vinblastine and vincristine, which are used in the clinical treatment of a variety of cancers. The two alkaloids, although structurally almost identical, nevertheless differ markedly in the type of tumors that they affect and in their toxic properties. These and related alkaloids have been the subject of many pharmacological and biochemical investigations both in vivo and in vitro in the search for improved cancer treatments. A model system used in these studies, a transplantable lymphoma in Noble strain rats designated Nb2 node, has serendipitously led to the development of a highly sensitive and specific bioassay for lactogenic hormones. (AU)


Assuntos
Ratos , Oncologia/história , Alcaloides de Vinca/história , /tratamento farmacológico , Ensaios de Seleção de Medicamentos Antitumorais , Hipoglicemiantes/história , Hipoglicemiantes/uso terapêutico , Jamaica , Linfoma/tratamento farmacológico , Linfoma/patologia , Medicina Tradicional , Neoplasias/tratamento farmacológico , Ontário , Extratos Vegetais/uso terapêutico , Células Tumorais Cultivadas/efeitos dos fármacos , Alcaloides de Vinca/isolamento & purificação , Alcaloides de Vinca/uso terapêutico
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