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1.
Rev Fac Cien Med Univ Nac Cordoba ; 77(1): 49-51, 2020 03 13.
Artigo em Espanhol | MEDLINE | ID: mdl-32238259

RESUMO

Introduction: celiac disease is a medical condition that is characterized by its varied forms of clinical presentation and its association with other autoimmune pathologies. The objective is to describe the case of a patient who presented for consultation due to alopecia areata. Methodology: observational, descriptive, retrospective study of a 24-year-old obese male Results: among the routine studies positive serology for celiac disease was detected and confirmed with digestive endoscopy. Conclusions: the alopecia areata of this patient allowed to reveal another autoimmune disease.


Assuntos
Alopecia em Áreas/etiologia , Doença Celíaca/complicações , Obesidade/complicações , Biópsia , Doença Celíaca/diagnóstico , Doença Celíaca/patologia , Humanos , Masculino , Estudos Retrospectivos , Adulto Jovem
4.
J Nepal Health Res Counc ; 17(1): 21-25, 2019 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-31110371

RESUMO

BACKGROUND: Alopecia areata is the commonest cause of non-scarring alopecia. Few previous studies have found correlation between AA and vitamin D deficiency, suggesting that vitamin D deficiency can be a risk factor for Alopecia areata. To compare serum vitamin D level between Alopecia areata patients and healthy controls; and to assess the relation between serum vitamin D levels and AA disease severity. METHODS: This case control study included 30 newly diagnosed Alopecia areata patients. Thorough history was taken, detail examination was done and relevant findings were recorded in the standardized pro-forma. Their serum vitamin D (25-hydroxyvitamin D) levels were determined by competitive chemiluminescence methods; and were compared with that of age and sex matched healthy controls. Chi square test and Spearman's rho correlation test were used for the inferential statistics using SPSS version 11.5. RESULTS: There were 30 AA patients with mean age 28.37+10.07 years. Mean Severity of Alopecia Tool score was 3.56+3.50. Prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency was significantly higher in AA group (83.3%) compared to the control group (53.3%) (P=0.01). Similarly, serum 25(OH)D level was reduced more in Alopecia areata group (12.84, IQR=8.87-20.47) than the control group (29.5, IQR=19.85-41.27) (P=0.06). There was inverse co-relation between serum 25(OH)D level and SALT score. CONCLUSIONS: Prevalence of serum 25(OH)D deficiency was significantly higher in Alopecia areata group compared to the control, with inverse co-relation between its level and Alopecia areata disease severity.


Assuntos
Alopecia em Áreas/etiologia , Deficiência de Vitamina D/complicações , Vitamina D/sangue , Adulto , Alopecia em Áreas/sangue , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Fatores de Risco , Índice de Gravidade de Doença , Deficiência de Vitamina D/sangue
5.
Curr Drug Saf ; 14(2): 167-170, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30767750

RESUMO

BACKGROUND: Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer an improved side effect profile compared to older treatments, which improves patients' adherence and quality of life. CASE REPORT: Here we discuss a case of an uncommon, but a distressing side effect of citalopram. A 76-year old woman was referred to the psychiatry clinic for bizarre behavior. The patient was diagnosed with behavioral variant frontotemporal dementia and was started on citalopram 20 mg and aripiprazole 5 mg daily. At 3.5 months the patient complained of diffuse hair thinning on her scalp. Citalopram was considered the offending agent and was discontinued. Within a few months, the patient regained most of her hair. Although drug-induced alopecia is common among other SSRIs, it is relatively rare with citalopram. RESULTS AND CONCLUSION: Early recognition, withdrawal of offending agent, and reassurance to the patient that hair loss is reversible can help alleviate patient distress and avoid relapse.


Assuntos
Alopecia em Áreas/etiologia , Citalopram/efeitos adversos , Idoso , Feminino , Humanos , Qualidade de Vida
6.
Mod Rheumatol ; 29(3): 538-541, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-27846747

RESUMO

A 53-year-old man with autoimmune pancreatitis as IgG4-related disease presented alopecia. Immunostaining showed perifollicular infiltration of IgG4-positive cells and perifollicular/intrafollicular infiltration of predominantly CD4-positive cells, especially in the upper and lower parts. Alopecia areata is characterized by perifollicular/intrafollicular lymphocyte infiltration of the lower bulb and inflammation in the upper dermis. We determined the patient had IgG4-related skin disease, rather than alopecia areata. Alopecia as IgG4-related skin disease has not been reported previously.


Assuntos
Alopecia em Áreas/diagnóstico , Doença Relacionada a Imunoglobulina G4/complicações , Alopecia em Áreas/etiologia , Alopecia em Áreas/imunologia , Linfócitos T CD4-Positivos/imunologia , Humanos , Doença Relacionada a Imunoglobulina G4/patologia , Masculino , Pessoa de Meia-Idade
7.
J Cosmet Dermatol ; 18(1): 401-407, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29774652

RESUMO

BACKGROUND: Diffuse hair loss (DHL) is a common problem in adult women and has a major impact on quality of life. Ascertaining the etiological diagnosis is a challenging task in such patients. Satisfactory treatment can only be instituted after ascertaining the cause of hair loss. OBJECTIVE: To study the clinico-epidemiological profile of nonscarring DHL in females and to ascertain its underlying etiological factors. STUDY DESIGN: Of a total of 110 females, who presented with nonscarring DHL to the outpatient dermatology department, 100 qualified for inclusion in the study. A detailed history, clinical examination, and laboratory investigations were performed in all the patients. Statistical analysis was performed on the data collected. RESULTS: Of 100 cases of DHL which were included in the study, commonest was chronic telogen effluvium (CTE) (62%), followed by female pattern hair loss (FPHL) (22%) and acute telogen effluvium (ATE) (16%). Incidence of hair loss was highest in 21-40 years age group. Psychological stress was seen to be a precipitating factor in 18 patients and found most commonly in women belong to CTE group (n-16, 25.8%). Hemoglobin levels ranged from 80 to 142 gm/L (mean: 119 ± 110). Low hemoglobin level (<120 gm/L) was observed in 57% patients. Total serum ferritin <10 ng/mL was seen in 20 patients, vitamin B12 < 211 pg/mL in 76 cases, vitamin D3 < 30 ng/mL in 81 cases. Subclinical hypothyroidism was present in 11% cases. CONCLUSIONS: Nonscarring DHL is a multifactorial condition with highest incidence in 21- to 40-year age group. Serum ferritin, serum vitamin B12, and D3 levels seem to have a contributing role in the pathogenesis of hair loss, and their supplementation may be needed for a faster regrowth of hair in all cases of hair loss irrespective of the pattern.


Assuntos
Alopecia em Áreas/epidemiologia , Alopecia em Áreas/etiologia , Adolescente , Adulto , Distribuição por Idade , Alopecia em Áreas/sangue , Colecalciferol/sangue , Feminino , Ferritinas/sangue , Hemoglobinas/metabolismo , Humanos , Hipotireoidismo/epidemiologia , Incidência , Índia/epidemiologia , Pessoa de Meia-Idade , Estudos Prospectivos , Estresse Psicológico/complicações , Centros de Atenção Terciária , Vitamina B 12/sangue , Adulto Jovem
8.
Clin Dermatol ; 36(6): 709-713, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30446192

RESUMO

Psychologic and social effects of scalp hair are more important than its biologic significance. Etiology of alopecia areata (AA) suggests a predominantly autoimmune reaction. Correlation between AA and psychologic disorders is reciprocal. Psychiatric disorders can trigger the onset of AA and its negative consequences may develop or exacerbate psychologic problems. The high incidence of a neurotic personality, depression, anxiety, and deficiency in coping with stress strengthen the role of psychic factors in the pathogenesis of AA. Strategies to assess these patients are often not apparent for the clinician and identifying patients in need of extra psychologic support should be a mainstay for successful treatment. Women, young patients, and those with significant AA or previous psychiatric disorders are at greater risk, requiring careful monitoring. Proper awareness and consciousness about the close relationship between AA and psychologic factors are essential.


Assuntos
Alopecia em Áreas/etiologia , Alopecia em Áreas/psicologia , Transtornos Mentais/psicologia , Transtornos Psicofisiológicos/psicologia , Estresse Psicológico/psicologia , Adaptação Psicológica , Nível de Saúde , Humanos , Qualidade de Vida
9.
Front Immunol ; 9: 1279, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29951053

RESUMO

The treatment of autoimmune diseases still poses a major challenge, frequently relying on non-specific immunosuppressive drugs. Current efforts aim at reestablishing self tolerance using immune cells with suppressive activity like the regulatory T cells (Treg) or the myeloid-derived suppressor cells (MDSC). We have demonstrated therapeutic efficacy of MDSC in mouse Alopecia Areata (AA). In the same AA model, we now asked whether MDSC exosomes (MDSC-Exo) can replace MDSC. MDSC-Exo from bone marrow cells (BMC) cultures of healthy donors could substantially facilitate treatment. With knowledge on MDSC-Exo being limited, their suitability needs to be verified in advance. Protein marker profiles suggest comparability of BMC- to ex vivo collected inflammatory MDSC/MDSC-Exo in mice with a chronic contact dermatitis, which is a therapeutic option in AA. Proteome analyses substantiated a large overlap of function-relevant molecules in MDSC and MDSC-Exo. Furthermore, MDSC-Exo are taken up by T cells, macrophages, NK, and most avidly by Treg and MDSC-Exo uptake exceeds binding of MDSC themselves. In AA mice, MDSC-Exo preferentially target skin-draining lymph nodes and cells in the vicinity of remnant hair follicles. MDSC-Exo uptake is accompanied by a strong increase in Treg, reduced T helper proliferation, mitigated cytotoxic activity, and a slight increase in lymphocyte apoptosis. Repeated MDSC-Exo application in florid AA prevented progression and sufficed for partial hair regrowth. Deep sequencing of lymphocyte mRNA from these mice revealed a significant increase in immunoregulatory mRNA, including FoxP3 and arginase 1. Downregulated mRNA was preferentially engaged in prohibiting T cell hyperreactivity. Taken together, proteome analysis provided important insights into potential MDSC-Exo activities, these Exo preferentially homing into AA-affected organs. Most importantly, changes in leukocyte mRNA seen after treatment of AA mice with MDSC-Exo sustainably supports the strong impact on the adaptive and the non-adaptive immune system, with Treg expansion being a dominant feature. Thus, MDSC-Exo could potentially serve as therapeutic agents in treating AA and other autoimmune diseases.


Assuntos
Alopecia em Áreas/etiologia , Alopecia em Áreas/metabolismo , Doenças Autoimunes/imunologia , Doenças Autoimunes/metabolismo , Exossomos/metabolismo , Células Supressoras Mieloides/imunologia , Células Supressoras Mieloides/metabolismo , Animais , Biomarcadores , Técnicas de Cocultura , Modelos Animais de Doenças , Feminino , Imunomodulação , Leucócitos/imunologia , Leucócitos/metabolismo , Camundongos , Fenótipo
10.
Rev Endocr Metab Disord ; 19(4): 311-323, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-29948572

RESUMO

The skin is the largest organ of the body, at the boundary with the outside environment. Primarily, it provides a physical and chemical barrier against external insults, but it can act also as immune organ because it contains a whole host of immune-competent cells of both the innate and the adaptive immune systems, which cooperate in eliminating invading pathogens following tissue injury. On the other hand, improper skin immune responses lead to autoimmune skin diseases (AISD), such as pemphigus, bullous pemphigoid, vitiligo, and alopecia. Although the interplay among genetic, epigenetic, and environmental factors has been shown to play a major role in AISD etiology and progression, the molecular mechanisms underlying disease development are far from being fully elucidated. In this context, epidemiological studies aimed at defining the association of different AISD with other autoimmune pathologies revealed possible shared molecular mechanism(s) responsible for disease progression. In particular, over the last decades, a number of reports have highlighted a significant association between thyroid diseases (TD), mainly autoimmune ones (AITD), and AISD. Here, we will recapitulate the epidemiology, clinical manifestations, and pathogenesis of the main AISD, and we will summarize the epidemiological evidence showing the associations with TD as well as possible molecular mechanism(s) underlying TD and AISD pathological manifestations.


Assuntos
Alopecia em Áreas , Doenças Autoimunes , Dermatite Herpetiforme , Psoríase , Dermatopatias Vesiculobolhosas , Doenças da Glândula Tireoide , Vitiligo , Alopecia em Áreas/epidemiologia , Alopecia em Áreas/etiologia , Alopecia em Áreas/imunologia , Doenças Autoimunes/epidemiologia , Doenças Autoimunes/etiologia , Doenças Autoimunes/imunologia , Dermatite Herpetiforme/epidemiologia , Dermatite Herpetiforme/etiologia , Dermatite Herpetiforme/imunologia , Humanos , Psoríase/epidemiologia , Psoríase/etiologia , Psoríase/imunologia , Dermatopatias Vesiculobolhosas/epidemiologia , Dermatopatias Vesiculobolhosas/etiologia , Dermatopatias Vesiculobolhosas/imunologia , Doenças da Glândula Tireoide/epidemiologia , Doenças da Glândula Tireoide/etiologia , Doenças da Glândula Tireoide/imunologia , Vitiligo/epidemiologia , Vitiligo/etiologia , Vitiligo/imunologia
13.
J Cosmet Dermatol ; 17(6): 1271-1274, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29336112

RESUMO

BACKGROUND/OBJECTIVES: Alopecia areata (AA) is an autoimmune disease characterized by noncicatricial hair loss localized on hair, beard, mustache, eyebrow, eyelash, and sometimes on the body. Although etiopathogenesis is not fully understood, many studies show remarkable associations between various diseases and ABO blood groups. However, there is no study with AA and blood groups. METHODS: Healthy people and patients with AA were included in this study. A total of 155 patients with AA and 299 healthy controls were included in the study. RESULTS: ABO blood group distribution in patients with AA and distribution of healthy donors were similar. However, Rhesus factor positivity in the AA group was significantly higher than in healthy donors. The relationship between stress and AA was high as known. But, ABO blood group and Rhesus factor were not in a significant connection with stress. CONCLUSION: We conclude that there was no association between ABO blood group and AA, but the observed distribution of Rhesus blood group differed slightly but significantly from that of the healthy population. The result of the study shows a small but statistically significant difference in the Rh blood group between patients with AA and the healthy population blood groups. This result is important because it suggests that genetic factors may influence the development of AA. The role of blood groups in the development of AA remains to be determined. We believe that the studies which will be carried out in other centers with wider series will be more valuable to support this hypothesis.


Assuntos
Sistema ABO de Grupos Sanguíneos , Alopecia em Áreas/sangue , Sistema do Grupo Sanguíneo Rh-Hr , Adulto , Alopecia em Áreas/etiologia , Estudos de Casos e Controles , Feminino , Humanos , Masculino
14.
Kathmandu Univ Med J (KUMJ) ; 16(62): 161-165, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30636758

RESUMO

Background Alopecia areata (AA) is one of the non-scarring alopecia. Its etiology has not been well established till date. The most convincing hypothesis is autoimmune process for its causation. Amongst all, most frequent association was found with thyroid disorder. Objective To study the association of thyroid dysfunction in patients with alopecia areata. Method All patients of alopecia areata attending dermatology outpatient department and currently not receiving any treatment for alopecia areata were enrolled in the study. Relevant history and examination findings were recorded in the preset pro-forma. All of them were subjected for thyroid function test by chemiluminescence microparticle immunoassay method. Then thyroid function test of cases was compared with that of equal number of age and sex matched healthy controls. Result A total of 75 patients were enrolled in both case and control groups. Mean age of case and control groups were 29.40±9.90 and 28.96±9.89 years respectively (P=0.786). Median Severity of Alopecia Tool score was 2.47 (IQR=0.96-5.79). Prevalence of thyroid disorder was significantly higher in alopecia areata group (17.3%) as compared to the control group (1.3%) (P=0.001). Likewise, in individuals with abnormal thyroid function, alopecia areata disease severity grade and median severity of alopecia tool (SALT) score was higher as compared to those with normal thyroid function. Conclusion We found a significant association between alopecia areata and thyroid dysfunction. Hence thyroid function evaluation must be considered in individuals with alopecia areata. However, further studies with larger sample size are recommended before its generalization.


Assuntos
Alopecia em Áreas/etiologia , Doenças da Glândula Tireoide/diagnóstico , Adulto , Alopecia em Áreas/complicações , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Nepal , Prevalência , Índice de Gravidade de Doença , Doenças da Glândula Tireoide/complicações , Testes de Função Tireóidea , Adulto Jovem
15.
J Investig Dermatol Symp Proc ; 19(1): S3-S8, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29273102

RESUMO

Alopecia areata (AA) is a common autoimmune skin disease that results in the loss of hair on the scalp and elsewhere on the body and affects over 146 million people worldwide at some point in their lives. Founded in 1981, the National Alopecia Areata Foundation is a nonprofit organization that supports research to find a cure or acceptable treatment for AA, supports those with the disease, and educates the public about AA. The National Alopecia Areata Foundation conducts research summits every 2 years to review progress and create new directions in its funded and promoted research. The Foundation brings together scientists from all disciplines to get a broad and varied perspective. These AA research summits are part of the Foundation's main strategic initiative, the AA Treatment Development Program, to enhance the understanding of AA and accelerate progress toward a viable treatment.


Assuntos
Alopecia em Áreas/terapia , Alopecia em Áreas/etiologia , Animais , Modelos Animais de Doenças , Fundações , Humanos , Pesquisa Médica Translacional/tendências
16.
J Invest Dermatol ; 138(3): 549-556, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29080678

RESUMO

Alopecia areata (AA) is one of the most common forms of human hair loss. Although genetic studies have implicated autoimmune processes in AA etiology, understanding of the etiopathogenesis is incomplete. Recent research has implicated microRNAs, a class of small noncoding RNAs, in diverse autoimmune diseases. To our knowledge, no study has investigated the role of microRNAs in AA. In this study, gene-based analyses were performed for microRNAs using data of the largest genome-wide association meta-analysis of AA to date. Nominally, significant P-values were obtained for 78 of the 617 investigated microRNAs. After correction for multiple testing, three of the 78 microRNAs remained significant. Of these, miR-30b/d was the most significant microRNA for the follow-up analyses, which also showed lower expression in the hair follicle of AA patients. Target gene analyses for the three microRNAs showed 42 significantly associated target genes. These included IL2RA, TNXB, and ERBB3, which had been identified as susceptibility loci in previous genome-wide association studies. Using luciferase assay, site-specific miR-30b regulation of the AA risk genes IL2RA, STX17, and TNXB was validated. This study implicates microRNAs in the pathogenesis of AA. This finding may facilitate the development of future treatment strategies.


Assuntos
Alopecia em Áreas/etiologia , MicroRNAs/fisiologia , Alopecia em Áreas/genética , Estudo de Associação Genômica Ampla , Células HEK293 , Humanos , Subunidade alfa de Receptor de Interleucina-2/genética , MicroRNAs/análise , Proteínas Qa-SNARE/genética , Tenascina/genética
19.
An Bras Dermatol ; 92(5): 724-726, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29166518

RESUMO

Yellow dots are follicular ostium filled with keratin and/or sebum. Initially, they were exclusively associated with alopecia areata. Currently they have also been described in androgenetic alopecia, chronic cutaneous (discoid) lupus erythematosus, and dissecting cellulitis. Due to the growing importance of trichoscopy and its findings in the evaluation of the scalp, this article describes the main diseases in which yellow dots are a common trichoscopic finding, highlighting its characteristics in each dermatosis.


Assuntos
Alopecia em Áreas/diagnóstico por imagem , Celulite (Flegmão)/diagnóstico por imagem , Dermatoses do Couro Cabeludo/diagnóstico por imagem , Dermatopatias Genéticas/diagnóstico por imagem , Alopecia em Áreas/etiologia , Celulite (Flegmão)/complicações , Dermoscopia , Diagnóstico Diferencial , Humanos , Dermatoses do Couro Cabeludo/complicações , Dermatopatias Genéticas/complicações
20.
Arch Argent Pediatr ; 115(6): e404-e411, 2017 Dec 01.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29087123

RESUMO

Alopecia areata (AA) is a dermatological disease characterized by non-scarring hair loss of the scalp and/or body, with an unpredictable and variable evolution in the patients in which, despite multidisciplinary efforts, its etiology is not entirely known, although some evidence suggests that environmental, immunological and genetic factors could be generating the disease. The aim of this review is to provide an updated panorama of the clinical characteristics, diagnosis and treatment of AA, to analyze the mechanisms that could participate in its etiology, as well as to review some of the most important genetic variants that could confer susceptibility to the development of this disease.


Assuntos
Alopecia em Áreas , Adolescente , Alopecia em Áreas/diagnóstico , Alopecia em Áreas/epidemiologia , Alopecia em Áreas/etiologia , Alopecia em Áreas/terapia , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Prognóstico
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