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1.
Medicine (Baltimore) ; 99(17): e19842, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32332635

RESUMO

INTRODUCTION: Seborrheic alopecia (SA) has clinical manifestations, duration of disease, and priorities. In the current situation where there are many and complicated clinical treatments, Western medicine treatment can delay and control the development of the disease and promote hair regeneration. However, some patients may aggravate symptoms after taking the drug, and the condition is easy to repeat after stopping the drug. Acupuncture is an important method for non-surgical treatment of SA, and it has various methods, low side effects, high safety, and simple and economical. Therefore, we will use a clinical randomized controlled study to explore the effect of acupuncture on SA, and provide a new idea and reference for the treatment of this disease. METHODS/DESIGN: We will select 60 patients diagnosed with SA. They will be randomly divided into intervention group and control groups. The control group will be given conventional treatment measures. The intervention group will receive acupuncture. Efficacy will be evaluated by comparing the skin lesion score and dermatological quality of life index before and after treatment. DISCUSSION: This trial may provide evidence regarding the clinical effectiveness, safety, and cost-effectiveness of acupuncture for patients with SA. TRIAL REGISTRATION NUMBER: CTR2000030430.


Assuntos
Terapia por Acupuntura , Alopecia/etiologia , Alopecia/terapia , Dermatite Seborreica/complicações , Terapia por Acupuntura/economia , Adolescente , Adulto , Análise Custo-Benefício , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Resultado do Tratamento , Adulto Jovem
2.
An Bras Dermatol ; 94(4): 479-481, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644627

RESUMO

A 63-year-old black female patient with blisters and exulcerations on the face, neck, upper limbs, and subsequent evolution with hypochromic sclerotic areas and alopecia, is reported. Chronic hepatitis C and presence of high levels of porphyrins in urine were demonstrated. There was complete remission with the use of hydroxychloroquine, photoprotection, and treatment of hepatitis. Significant sclerodermoid involvement of the skin as a manifestation of porphyria cutanea tarda secondary to hepatitis C emphasizes the importance of diagnostic suspicion regarding skin manifestation in order to indicate the appropriate therapy, and to minimize the hepatic morbidity.


Assuntos
Hepatite C Crônica/complicações , Hepatite C Crônica/patologia , Porfiria Cutânea Tardia/etiologia , Porfiria Cutânea Tardia/patologia , Esclerodermia Localizada/etiologia , Esclerodermia Localizada/patologia , Alopecia/etiologia , Feminino , Hepatite C Crônica/terapia , Humanos , Pessoa de Meia-Idade , Porfiria Cutânea Tardia/terapia , Esclerodermia Localizada/terapia , Resultado do Tratamento
4.
Dermatol Online J ; 25(8)2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31553869

RESUMO

Folliculitis decalvans is a rare scarring alopecia that presents with indurated, tender pustules and papules on the vertex and occipital scalp. Although systemic antibiotics with activity against Staphylococcus species provide some symptomatic improvement, folliculitis decalvans remains a significant management challenge and often exhibits a relapsing-and-remitting course. In this report, we posit the potential utility of medical grade honey as a safe and cost-effective adjuvant therapy in the treatment of folliculitis decalvans. We describe a patient with painful, boggy scalp pustules who achieved clearance of his scalp lesions with the addition of Manuka honey. To our knowledge, this report is the first to demonstrate the clinical use of honey in the management of folliculitis decalvans and may lend support to the role of Staphylococcus in the pathogenesis of this disease.


Assuntos
Alopecia/terapia , Foliculite/terapia , Mel , Dermatoses do Couro Cabeludo/terapia , Infecções Cutâneas Estafilocócicas/terapia , Alopecia/etiologia , Alopecia/patologia , Antibacterianos/uso terapêutico , Cefalexina/uso terapêutico , Foliculite/complicações , Foliculite/patologia , Glucocorticoides/uso terapêutico , Humanos , Injeções Intralesionais , Masculino , Dermatoses do Couro Cabeludo/complicações , Dermatoses do Couro Cabeludo/patologia , Infecções Cutâneas Estafilocócicas/complicações , Infecções Cutâneas Estafilocócicas/patologia , Falha de Tratamento , Adulto Jovem
5.
Zoo Biol ; 38(5): 434-441, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31418481

RESUMO

The Andean bear alopecia syndrome is a progressive and chronic condition documented in ex situ populations. Recent advances focus on treating symptoms, not preventing future cases. We therefore explored the epidemiology of this syndrome through an analysis of husbandry and veterinary conditions of 63 Andean bears (26M:37F) housed in North and South American zoos and other ex situ circumstances. We had the most complete information for the North American population and found that 29% of females (n = 24) were affected. No males (n = 26) were affected. An analysis of generalized linear models indicated that three models were competitive in describing the occurrence of the condition (i.e., ΔAICc ≤ 2): the model including only the individual's sex (χ2 = 13.41, df = 1, p < .001), the model including both individual sex and social housing status (χ2 = 1.36, df = 2, p < .001), and the model including both individual sex and the expression of stereotypical behaviors (χ2 = 13.82, df = 2, p = .001). Stereotypical behaviors were common among both males (50%, n = 26) and females (51.9%, n = 27) whether or not they were affected, but the syndrome was seen only in females who had been socially housed. Therefore, we suggest that the Andean bear alopecia syndrome is a symptomatic response to the long-term social housing of bears that would otherwise not live socially. To prevent new cases, we recommend that female Andean bears be housed with adult conspecifics only when females choose to cohabitate.


Assuntos
Alopecia/veterinária , Abrigo para Animais , Ursidae , Alopecia/etiologia , Criação de Animais Domésticos , Animais , Animais de Zoológico , Feminino , Masculino , América do Norte , América do Sul
10.
An. bras. dermatol ; 94(4): 479-481, July-Aug. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1038315

RESUMO

Abstract: A 63-year-old black female patient with blisters and exulcerations on the face, neck, upper limbs, and subsequent evolution with hypochromic sclerotic areas and alopecia, is reported. Chronic hepatitis C and presence of high levels of porphyrins in urine were demonstrated. There was complete remission with the use of hydroxychloroquine, photoprotection, and treatment of hepatitis. Significant sclerodermoid involvement of the skin as a manifestation of porphyria cutanea tarda secondary to hepatitis C emphasizes the importance of diagnostic suspicion regarding skin manifestation in order to indicate the appropriate therapy, and to minimize the hepatic morbidity.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Esclerodermia Localizada/etiologia , Porfiria Cutânea Tardia/etiologia , Porfiria Cutânea Tardia/patologia , Hepatite C Crônica/complicações , Hepatite C Crônica/patologia , Esclerodermia Localizada/patologia , Esclerodermia Localizada/terapia , Resultado do Tratamento , Porfiria Cutânea Tardia/terapia , Hepatite C Crônica/terapia , Alopecia/etiologia
11.
Pediatr Dermatol ; 36(5): 697-701, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31355463

RESUMO

Erosive pustular dermatosis of the scalp (EPDS) is an uncommon chronic inflammatory response to scalp trauma that usually resolves with cicatricial alopecia. It most commonly affects elderly patients with a history of actinic damage. Herein, we describe a 16-year-old girl with acrofacial dysostosis type 1 presenting after surgery with crusting purulent scalp lesions, whose clinical presentation and histopathologic findings were consistent with EPDS. A review of the literature on EPDS in children is also detailed.


Assuntos
Alopecia/etiologia , Alopecia/patologia , Dermatoses do Couro Cabeludo/patologia , Dermatopatias Vesiculobolhosas/patologia , Adolescente , Alopecia/terapia , Feminino , Humanos , Dermatoses do Couro Cabeludo/complicações , Dermatoses do Couro Cabeludo/terapia , Dermatopatias Vesiculobolhosas/complicações , Dermatopatias Vesiculobolhosas/terapia
12.
Int J Mol Sci ; 20(14)2019 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-31337037

RESUMO

Hair bio-engineering has risen at the crossing point of various manipulations to meet a clinical requirement for innovations to advance hair growth. The authors reported the microscopic and trichoscopic results of an autologous cell biological technique to compare, through histological, immunocytochemistry, and cytospin analysis, hair re-growth obtained by micro-grafts from scalp tissue containing Human Intra- and Extra-Dermal Adipose Tissue-Derived Hair Follicle Stem Cells (HD-AFSCs) versus placebo (saline solution). An autologous solution of micro-grafts was obtained from mechanical fragmentation and centrifugation of scalp biopsy's (2 × 2 mm) using "Gentile protocol". The micro-grafts solution was mechanically infiltrated on half of the selected patients' scalps with Androgenic Alopecia (Norwood-Hamilton 2-5 and Ludwig 1-2). The other half was infiltrated with saline solution. Three injections were performed to each patient at 45-day intervals. Of the 35 patients who were enrolled, 1 was excluded and 1 was rejected. 23 and 44 weeks after the last micro graft's injections, the patients displayed a hair density improvement, with a mean increment of 33% ± 7.5% and 27% ± 3.5% respectively, contrasted with baseline values, for the treated region. Microscopic assessment appeared, in scalp biopsies, to show an expansion in the number of hair follicles per mm2 following 11 months from the last micro-grafts application compared with baseline (1.4 + 0.27 versus 0.46 + 0.15, respectively; p < 0.05). HD-AFSCs contained in micro-grafts may represent a safe and effective alternative therapy option against hair loss.


Assuntos
Tecido Adiposo/citologia , Tecido Adiposo/metabolismo , Alopecia/metabolismo , Alopecia/terapia , Folículo Piloso/citologia , Transplante de Células-Tronco , Células-Tronco/metabolismo , Alopecia/diagnóstico , Alopecia/etiologia , Animais , Biomarcadores , Derme/citologia , Humanos , Imunofenotipagem , Fenótipo , Transplante Autólogo , Resultado do Tratamento
13.
Clin Dermatol ; 37(3): 182-191, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31178101

RESUMO

Despite advances in the control, diagnosis, and treatment of syphilis, its recognition is ill- understood or often not considered by dermatologists and other physicians who either have little specialized training in the minutiae of sexually transmitted infections (STIs) or whose dermatologic practice is only occasionally consulted by individuals from communities where STIs are prevalent. Our aim is to highlight contemporary ideas and findings on syphilis so that not only is an accurate diagnosis of syphilis made and recognized treatment given, but also necessary measures, such as counseling to exclude other STIs and to prevent reinfection, partner notification, and public health epidemiology as for any other infectious disease, are not forgotten. For syphilis, like human immunodeficiency virus (HIV) infection, not only is the biomedical aspect important, but also are the social and psychologic components.


Assuntos
Sífilis , Alopecia/etiologia , Diagnóstico Diferencial , Doxiciclina/administração & dosagem , Feminino , Infecções por HIV , Humanos , Infusões Intravenosas , Injeções Intramusculares , Masculino , Membrana Mucosa/patologia , Neurossífilis , Penicilina G Benzatina/administração & dosagem , Gravidez , Prevenção Secundária , Pele/patologia , Sífilis/diagnóstico , Sífilis/tratamento farmacológico , Sífilis/patologia , Sífilis/transmissão , Sorodiagnóstico da Sífilis/métodos , Tetraciclina/administração & dosagem
15.
World Neurosurg ; 130: e222-e229, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31203064

RESUMO

OBJECTIVE: To present values for the dose parameters predictive of alopecia as an adverse effect induced by neuroembolization using a biplane fluoroscopy. METHODS: This study included a total of 151 patients (52 men, mean age of 55.1 ± 12.2 years) treated for intracranial neuroembolization between 2014 to 2018 with the following criteria: 1) obtainable dose report with digital subtraction angiographic image records, 2) no history of radiation exposure 6 months prior to the first procedure, and 3) and clinical follow-up performed through 12 months following the procedure. Patients were divided into 2 groups according to their presentation of alopecia during the follow-up period. RESULTS: Eighteen (11.9%) patients developed alopecia 10 to 30 days after the procedure (average: 18.5 ± 5.3 days). Sixteen (88.9%) patients in the alopecia group were affected by projection of the A-plane fluoroscopy. Area under the receiver operating characteristic analysis curves of 0.865 (P = 0.000) and 0.831 (P = 0.000) were used to compute the optimal A-plane dose area product (255.4 Gy-cm2; sensitivity: 0.875; specificity: 0.805; Youden J = 0.682) and cumulative dose (4437.5 mGy; sensitivity, 0.750; specificity, 0.805; Youden J = 0.556) cutoff values, respectively, capable of distinguishing patients with alopecia (n = 16) from subtotal patients (n = 149). CONCLUSIONS: The dose area product and the cumulative dose may be useful, intuitive factors for predicting the adverse effects of the neurointerventional radiation. Further multicenter research should be performed to confirm the efficacy and utility of the reference values of dose area product and cumulative dose for preventing excessive irradiation during neurointerventional procedures.


Assuntos
Alopecia/diagnóstico por imagem , Alopecia/etiologia , Embolização Terapêutica/efeitos adversos , Doses de Radiação , Exposição à Radiação/efeitos adversos , Radiografia Intervencionista/efeitos adversos , Adulto , Idoso , Embolização Terapêutica/métodos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Radiografia Intervencionista/métodos , Estudos Retrospectivos
17.
J Cosmet Dermatol ; 18(4): 966-975, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30980598

RESUMO

The second most common alopecia-Androgenetic alopecia (AGA)-occurs due to hormonal imbalance. Dihydrotestosterone (DHT) an androgenic hormone is a sex steroid, produced in the gonads. The target sites of DHT are similar to that of testosterone, and it attaches easily remaining bound for 53 minutes as compared to 35 minutes of testosterone. Excess of DHT causes miniaturization of hair reducing the anagen phase and increasing the telogen phase leading to hair loss. Normally up to ten percent of testosterone in the body irreversibly gets converted into DHT by the action of enzyme 5-alpha-reductase. Inadequate blood flow to the scalp can also be another reason for hair loss encountered due to lower oxygen and nutrients reaching it. AGA affects both sexes; however in males, it leads to major hair loss. Conventional drugs such as minoxidil and finasteride are widely used for the treatment. However, several drawbacks such as allergic contact dermatitis, burning, ejaculation disorder, and decreased libido are reported. Available literature suggests the role of herbal drugs to have the action against 5-alpha-reductase enzyme inhibiting it and reducing the hair loss. This can be further potentiated since they exhibit lesser side effects. Recent advancements observed in the medicinal, cosmetic, and engineering fields can prove to be an asset. This article focuses on herbs which can be used in AGA. A review of Saw palmetto (Serenoa repens), Green tea (Camellia sinensis), Pumpkin seed (Curcurbita pepo), Rosemary (Rosmarinus officinalis), Grape seed (Vitis vinifera), and Licorice (Glycyrrhiza glabra) is attempted.


Assuntos
Inibidores de 5-alfa Redutase/uso terapêutico , Alopecia/tratamento farmacológico , Di-Hidrotestosterona/antagonistas & inibidores , Extratos Vegetais/uso terapêutico , Inibidores de 5-alfa Redutase/farmacologia , Alopecia/etiologia , Camellia sinensis/química , Cucurbita/química , Di-Hidrotestosterona/metabolismo , Glycyrrhiza/química , Cabelo/efeitos dos fármacos , Cabelo/crescimento & desenvolvimento , Humanos , Extratos Vegetais/farmacologia , Serenoa/química , Vitis/química
18.
Seizure ; 69: 61-69, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30981051

RESUMO

PURPOSE: We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy. METHODS: We retrieved relevant publications and gathered data on alopecia in patients taking VPA and other drugs from prospective studies. RESULTS: Twenty-five articles met the inclusion criteria, and the overall incidence of alopecia in patients receiving VPA therapy was 11% (95% confidence interval (CI): 0.08-0.13). The pooled risk of alopecia showed a significant difference between patients treated with VPA and all other drugs (odds ratio (OR) 5.02, 95% CI: 3.58-7.03), other epileptic drugs (AEDs) (OR 4.82, 95% CI: 3.32-7.00) and other non-AEDs (OR 5.84, 95% CI: 2.67-12.81). Compared to other drugs, VPA increased the risk of alopecia both in patients with migraine headaches (OR 6.05, 95% CI: 2.89-12.63) and patients with epilepsy (OR 5.29, 95% CI: 3.53-7.92), and the increase risk was reported more frequently in patients with migraine. Both lower doses (OR 4.38, 95% CI: 2.32-8.25) and shorter treatments (OR 4.98, 95% CI: 2.41-10.25) with VPA posed a high risk of alopecia compared to other drugs, as did higher doses and longer treatment times. CONCLUSIONS: Based on our findings, VPA was significantly associated with a risk of alopecia compared to other drugs, and the risk did not depend on the dose and treatment time.


Assuntos
Alopecia/epidemiologia , Alopecia/etiologia , Epilepsia/tratamento farmacológico , Ácido Valproico/efeitos adversos , Ácido Valproico/uso terapêutico , Anticonvulsivantes/efeitos adversos , Anticonvulsivantes/uso terapêutico , Humanos , Incidência , Estudos Prospectivos
19.
Molecules ; 24(7)2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30939852

RESUMO

Ancocyanin-rich blackcurrant extract (BCE) has phytoestrogen activity; however, its effect on hair follicles is unknown. Additionally, hair loss is known to occur during menopause in women owing to decreased estrogen secretion. This study examined whether BCE alleviated female pattern hair loss using a rat model. RNA was extracted and analyzed using a microarray and ingenuity pathway analysis. A quantitative polymerase chain reaction revealed that 1 µg/mL BCE altered many genes downstream of beta-estradiol in human hair dermal papilla cells. Additionally, the expression of the hair follicle stem cell marker keratin 19 was greatly enhanced. In a menopause model, ovariectomized rats were fed a diet containing 3% BCE for three months. An analysis of the number of hair shafts revealed that BCE increased the number of hairs by 0.5 hairs/follicular unit. Moreover, immunostaining revealed that the expression of Ki67 also increased by 19%. Furthermore, fluorescent immunostaining showed that the expression of other stem cell markers, including keratin 15, CD34, and keratin 19, was induced in rat hair follicular cells. In conclusion, these findings suggest that BCE has phytoestrogen activity in hair follicles and contributes to the alleviation of hair loss in a menopausal model in rats.


Assuntos
Alopecia/prevenção & controle , Folículo Piloso/efeitos dos fármacos , Ovariectomia , Fitoestrógenos/farmacologia , Extratos Vegetais/farmacologia , Ribes/química , Alopecia/etiologia , Alopecia/patologia , Animais , Feminino , Perfilação da Expressão Gênica , Folículo Piloso/metabolismo , Folículo Piloso/patologia , Ratos , Ratos Sprague-Dawley
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