Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.374
Filtrar
1.
Life Sci ; 242: 117227, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31881226

RESUMO

INTRODUCTION: Misuse of AAS is emergent among both genders, however, few studies were performed evaluating AAS effects on female body and none evaluate the impact of nandrolone decanoate (ND) in renal function. AIM: Determine the effects of chronic treatment with ND on kidney function of female rats and evaluate the influence of oxidative stress on it. MATERIAL AND METHODS: Female rats were separated into two groups (n = 8 each), the treated group (DECA), which received ND at a dose of 20 mg/kg/week (i.m), and the control group (C), which was treated with the vehicle (peanut oil, i.m.). All treatments were performed during eight weeks. After this period, 24 h urine, blood and organs (heart, gastrocnemius muscle, liver and kidney) were collected. Organ hypertrophy was calculated, and kidney collagen content was evaluated. AOPP, TBARS, SOD and catalase activity were determined in the kidney. Moreover, proteinuria and creatinine clearance were also investigated. KEY-FINDINGS: Hypertrophy was observed in the liver, gastrocnemius muscle, heart and kidney. Kidney hypertrophy was followed by a reduced organ function and an increase in collagen deposition. Oxidative stress upsurge occurred in both proteins and lipids, followed by a reduction in SOD activity. SIGNIFICANCE: Administration of DN in rats was followed by renal damage and kidney fibrosis due to increased oxidative stress on that organ.


Assuntos
Lesão Renal Aguda/induzido quimicamente , Anabolizantes/efeitos adversos , Homeostase/efeitos dos fármacos , Decanoato de Nandrolona/efeitos adversos , Estresse Oxidativo/efeitos dos fármacos , Lesão Renal Aguda/metabolismo , Lesão Renal Aguda/fisiopatologia , Anabolizantes/farmacologia , Animais , Western Blotting , Catalase/metabolismo , Feminino , Rim/efeitos dos fármacos , Rim/metabolismo , Rim/patologia , Rim/fisiologia , Decanoato de Nandrolona/farmacologia , Ratos , Ratos Wistar , Superóxido Dismutase/metabolismo
2.
J Forensic Leg Med ; 68: 101871, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31557629

RESUMO

Anabolic-androgenic steroids (AAS) are image and performance enhancing drugs (IPEDs) that can improve endurance and athletic performance, reduce body fat and stimulate muscle growth. The use of steroids has been studied in the medical and psychological literature, in the sociology of sport, health and masculinity, and relatively recently in criminology. Whilst there is significant medical and psychological evidence on the short term and longer side effects of AAS, there is surprisingly very little evidence based on the users' perception of the negative aspects of AAS use. Drawing on ethnographic research conducted in a locale in the Northeast of England and additional interviews with 24 AAS users, the article offers an account of the negatives aspects of AAS as put forwards by users (acne, abscess, and mood alterations), and highlights the 'code of silence' that exists around AAS use. This 'code' makes AAS users a 'hard-to-reach' group for medical professionals. By listening to the participants' perspectives, forensic and medical professionals can be better informed towards monitoring and reducing harms from AAS.


Assuntos
Anabolizantes/efeitos adversos , Atletas/psicologia , Doping nos Esportes , Doping nos Esportes/psicologia , Humanos , Entrevistas como Assunto , Masculino
3.
Forensic Sci Int ; 303: 109925, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31499423

RESUMO

A 34-year old male was found breathless and panting at home by his girlfriend three hours after a gym workout. Minutes later, he collapsed and died. Autopsy, histological and chemical analyses were conducted. The examination of the heart showed left ventricular hypertrophy, while the right coronary artery showed only a small vascular lumen (3 mm in diameter), due to its anatomical structure. In femoral blood concentrations of approx. 1 µg/L clenbuterol, approx. 56 µg/L stanozolol and approx. 8 µg/L metandienone, with trenbolone (

Assuntos
Anabolizantes/efeitos adversos , Clembuterol/efeitos adversos , Doping nos Esportes , Metandrostenolona/efeitos adversos , Estanozolol/efeitos adversos , Adulto , Anabolizantes/análise , Androstanóis/urina , Clembuterol/análise , Clomifeno/urina , Vasos Coronários/patologia , Evolução Fatal , Insuficiência Cardíaca/induzido quimicamente , Humanos , Hipertrofia Ventricular Esquerda/patologia , Masculino , Metandrostenolona/análise , Estanozolol/análise , Testosterona/análogos & derivados , Testosterona/urina , Acetato de Trembolona/sangue , Acetato de Trembolona/urina
4.
Forensic Sci Med Pathol ; 15(4): 616-621, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31359306

RESUMO

Even if there are well-known consequences of anabolic androgenic steroid (AAS) abuse, their full pathway of action is still being investigated. In this context, the presented case report aims to discuss and provide evidence of unusual adverse effects linked to immunodeficiency in an AAS abuser. In fact, this kind of chronic complication, even if not usually considered, may lead sudden death. In this case a 31-year-old aesthetic weightlifter, who presented to the emergency department due to an accidental fall that resulted in left thigh trauma. This subsequently developed into left thigh necrotizing myofasciitis in the following few days. Although surgery and hyperbaric therapy were carried out, the man died. An autopsy with complete biological sampling for toxicological studies was performed. This case highlights the close relationship between AAS abuse and immunodeficiency and highlights it's importance for further studies. However, it should be considered that of all the dangerous effects produced by AAS use, necrotizing fasciitis is not such an unusual consequence.


Assuntos
Anabolizantes/efeitos adversos , Fasciite Necrosante/etiologia , Hospedeiro Imunocomprometido , Miosite/etiologia , Transtornos Relacionados ao Uso de Substâncias/complicações , Acidentes por Quedas , Adulto , Anabolizantes/administração & dosagem , Fasciite Necrosante/patologia , Evolução Fatal , Humanos , Injeções Intramusculares , Masculino , Miosite/patologia , Coxa da Perna , Levantamento de Peso
5.
BMJ Case Rep ; 12(6)2019 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-31175112

RESUMO

Anabolic steroid use is prevalent among athletes and bodybuilders. There are known cardiovascular, reproductive, musculoskeletal and neuropsychiatric risks associated with their prolonged use. Although there have been very few documented cases of strokes associated with anabolic steroid use, cardiomyopathy and secondary erythropoiesis can increase the risk of strokes in users with no other risk factors. We present a 49-year-old man with left parietal ischaemic stroke with haemorrhagic conversion resulting in Gerstmann syndrome secondary to a hypercoagulable state from chronic anabolic steroid use.


Assuntos
Anabolizantes/efeitos adversos , Síndrome de Gerstmann/diagnóstico , Esteroides/efeitos adversos , Isquemia Encefálica/induzido quimicamente , Isquemia Encefálica/diagnóstico por imagem , Hemorragia Cerebral/induzido quimicamente , Hemorragia Cerebral/diagnóstico por imagem , Hemorragia Cerebral/terapia , Síndrome de Gerstmann/induzido quimicamente , Humanos , Masculino , Pessoa de Meia-Idade , Flebotomia , Policitemia/induzido quimicamente , Policitemia/diagnóstico por imagem , Levantamento de Peso
6.
Psychopharmacology (Berl) ; 236(9): 2667-2676, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30941469

RESUMO

RATIONALE: Illicit use of anabolic androgenic steroids (AAS) has grown into a serious public health concern throughout the Western World. AAS use is associated with adverse medical, psychological, and social consequences. Around 30% of AAS users develop a dependence syndrome with sustained use despite adverse side effects. AAS dependence is associated with a high frequency of intra- and interpersonal problems, and it is central to identify factors related to the development and maintenance of dependence. METHODS: The present study investigated the ability to recognize emotion from biological motion. The emotional biological motion task was administered to male AAS dependent users (AAS dependents; n = 45), AAS non-dependent users (AAS non-dependents; n = 38) and a comparison-group of non-using weightlifters (non-users; n = 69). RESULTS: Multivariate analysis of variance showed a general impairment in emotion recognition in AAS dependents, compared to the non-using weightlifters, whereas no significant impairment was observed in AAS non-dependents. Furthermore, AAS dependents showed impaired recognition of fearful stimuli compared to both AAS non-dependents and non-using weightlifters. The between-group effect remained significant after controlling for Intelligence Quotient (IQ), past 6 months of non-AAS drug use, antisocial personality problems, anxiety, and depression. CONCLUSION: AAS dependents show impaired emotion recognition from body movement, fear in particular, which could potentially contribute to higher frequency of interpersonal problems and antisocial behaviors in this population.


Assuntos
Anabolizantes/efeitos adversos , Androgênios/efeitos adversos , Emoções/efeitos dos fármacos , Movimento/efeitos dos fármacos , Transtornos Relacionados ao Uso de Substâncias/psicologia , Adulto , Anabolizantes/administração & dosagem , Androgênios/administração & dosagem , Transtornos de Ansiedade/induzido quimicamente , Transtornos de Ansiedade/psicologia , Estudos Transversais , Depressão/induzido quimicamente , Depressão/psicologia , Emoções/fisiologia , Humanos , Masculino , Movimento/fisiologia , Estimulação Luminosa/métodos , Treinamento de Resistência/métodos , Transtornos Relacionados ao Uso de Substâncias/diagnóstico , Congêneres da Testosterona/administração & dosagem , Congêneres da Testosterona/efeitos adversos , Adulto Jovem
7.
J Pharmacol Exp Ther ; 369(2): 188-199, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30819762

RESUMO

The anabolic effects of ß 2-adrenoceptor (ß 2-AR) agonists on skeletal muscle have been demonstrated in various species. However, the clinical use of ß 2-AR agonists for skeletal muscle wasting conditions has been limited by their undesired cardiovascular effects. Here, we describe the preclinical pharmacological profile of a novel 5-hydroxybenzothiazolone (5-HOB) derived ß 2-AR agonist in comparison with formoterol as a representative ß 2-AR agonist that have been well characterized. In vitro, 5-HOB has nanomolar affinity for the human ß 2-AR and selectivity over the ß 1-AR and ß 3-AR. 5-HOB also shows potent agonistic activity at the ß 2-AR in primary skeletal muscle myotubes and induces hypertrophy of skeletal muscle myotubes. Compared with formoterol, 5-HOB demonstrates comparable full-agonist activity on cAMP production in skeletal muscle cells and skeletal muscle tissue-derived membranes. In contrast, a greatly reduced intrinsic activity was determined in cardiomyocytes and cell membranes prepared from the rat heart. In addition, 5-HOB shows weak effects on chronotropy, inotropy, and vascular relaxation compared with formoterol. In vivo, 5-HOB significantly increases hind limb muscle weight in rats with attenuated effects on heart weight and ejection fraction, unlike formoterol. Furthermore, changes in cardiovascular parameters after bolus subcutaneous treatment in rats and rhesus monkeys are significantly lower with 5-HOB compared with formoterol. In conclusion, the pharmacological profile of 5-HOB indicates superior tissue selectivity compared with the conventional ß 2-AR agonist formoterol in preclinical studies and supports the notion that such tissue-selective agonists should be investigated for the safe treatment of muscle-wasting conditions without cardiovascular limiting effects.


Assuntos
Benzotiazóis/química , Benzotiazóis/farmacologia , Sistema Cardiovascular/efeitos dos fármacos , Músculo Esquelético/efeitos dos fármacos , Receptores Adrenérgicos beta 2/metabolismo , Segurança , Agonistas de Receptores Adrenérgicos beta 2/efeitos adversos , Agonistas de Receptores Adrenérgicos beta 2/química , Agonistas de Receptores Adrenérgicos beta 2/farmacologia , Agonistas de Receptores Adrenérgicos beta 2/uso terapêutico , Anabolizantes/efeitos adversos , Anabolizantes/química , Anabolizantes/farmacologia , Anabolizantes/uso terapêutico , Animais , Benzotiazóis/efeitos adversos , Benzotiazóis/uso terapêutico , Células CHO , Cricetulus , Coração/efeitos dos fármacos , Humanos , Hipertrofia/tratamento farmacológico , Cinética , Macaca mulatta , Masculino , Músculo Esquelético/metabolismo , Músculo Esquelético/patologia , Miócitos Cardíacos/efeitos dos fármacos , Ratos
8.
J Forensic Leg Med ; 64: 28-30, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30921558

RESUMO

Anabolic androgenic steroids (AAS) are the drug of choice in many cultures of the UK. Whilst there is an abundance of evidence relating to the physiological and psychological effects of steroid abuse on the individual, surprisingly there is a paucity of information relating to the perspectives of steroid users regarding the social impact of steroid use on self and society. The lack of data from steroid users has implications for forensic and legal medicine. Specifically, evidence is limited in terms of the user's voice. This is a crucial omission; the unheard voices of steroid users have much to offer into future research. 24 IPED using participants (using substituted names to protect anonymity), engaged in semi structured interviews to discuss their own personal usage, culture issues, social media and more.


Assuntos
Anabolizantes/efeitos adversos , Imagem Corporal , Substâncias para Melhoria do Desempenho/efeitos adversos , Mídias Sociais , Anabolizantes/provisão & distribução , Informação de Saúde ao Consumidor , Humanos , Entrevistas como Assunto , Substâncias para Melhoria do Desempenho/provisão & distribução , Transtornos Relacionados ao Uso de Substâncias/psicologia , Reino Unido , Levantamento de Peso
9.
Orthop Clin North Am ; 50(2): 171-179, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30850076

RESUMO

Active assessment and management of hypovitaminosis D among orthopedic patients is low-risk and low-cost while retaining significant potential to improve patient care. Vitamin D has an established role in musculoskeletal development and calcium homeostasis, and vitamin D deficiency is pervasive in orthopedic trauma populations. Clinical guidelines for screening and supplementation for hypovitaminosis D are lacking. Literature on the effects of vitamin K on bone health is limited. Anabolic hormone analogues may have a future role in delayed union or nonunion treatment. Vitamin D deficiency and other endocrine abnormalities should be considered in orthopedic trauma patients presenting with fracture nonunion of uncertain cause.


Assuntos
Fraturas não Consolidadas/etiologia , Fraturas não Consolidadas/prevenção & controle , Sistema Musculoesquelético/efeitos dos fármacos , Deficiência de Vitamina D/epidemiologia , Vitamina D/administração & dosagem , Adulto , Idoso , Anabolizantes/efeitos adversos , Antifibrinolíticos/uso terapêutico , Conservadores da Densidade Óssea/uso terapêutico , Cálcio/administração & dosagem , Cálcio/uso terapêutico , Programas de Triagem Diagnóstica/normas , Feminino , Fraturas não Consolidadas/fisiopatologia , Homeostase/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Resultado do Tratamento , Vitamina D/uso terapêutico , Deficiência de Vitamina D/etiologia , Deficiência de Vitamina D/prevenção & controle , Vitamina K/administração & dosagem , Vitamina K/uso terapêutico
10.
Exp Clin Transplant ; 17(Suppl 1): 169-171, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30777547

RESUMO

Posttransplant diabetes is a common complication of solid-organ transplantation. We present the possible role of diabetes education in improvement of posttransplant diabetes in a 36-year-old bodybuilder who was a kidney transplant recipient. The patient had been abusing some medications to help in bodybuilding. He underwent living unrelated-donor renal transplant with thymoglobulin induction and was maintained on steroids, tacrolimus, and mycophenolate mofetil. Posttransplant diabetes was confirmed by blood tests. His blood sugar was partially controlled by 3 oral agents. The patient participated in our structured diabetes education program. This program was created to cover different items related to diabetes control, including diet, proper exercise, blood sugar monitoring, sick day management, and pathophysiologic roles of diabetes medications. Within 4 months of participation in this program, the patient's blood sugar became well controlled and his diabetes medications started to be minimized. He presently has stable graft function with hemoglobin A1c level around 5.6% on only diet management. Bodybuilders are at risk of deterioration of their kidney function. A proper diabetes education program is recommended to help renal transplant recipients with early posttransplant diabetes mellitus to control their disease. Success requires close evaluation and a multidisciplinary approach.


Assuntos
Glicemia/efeitos dos fármacos , Composição Corporal , Diabetes Mellitus/tratamento farmacológico , Hipoglicemiantes/administração & dosagem , Transplante de Rim/efeitos adversos , Educação de Pacientes como Assunto/métodos , Autocuidado/métodos , Levantamento de Peso , Administração Oral , Adulto , Anabolizantes/efeitos adversos , Biomarcadores/sangue , Glicemia/metabolismo , Monitorização Ambulatorial da Pressão Arterial , Composição Corporal/efeitos dos fármacos , Diabetes Mellitus/sangue , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/etiologia , Exercício , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Hipoglicemiantes/efeitos adversos , Imunossupressores/uso terapêutico , Masculino , Adesão à Medicação , Fatores de Risco , Comportamento de Redução do Risco , Transtornos Relacionados ao Uso de Substâncias/complicações , Fatores de Tempo , Resultado do Tratamento
11.
J Sports Med Phys Fitness ; 59(3): 489-495, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29687691

RESUMO

BACKGROUND: A large number of Saudi athletes are recently shown to use androgenic anabolic steroid (AAS) products to achieve rapid muscle growth without realizing the serious health risks of these drugs. Aim of this study was to elucidate the side effects encountered with prolonged use of AAS products by Saudi athletes. METHODS: A cross-sectional study was conducted, in which 16 regular gym members, 12 of them used AAS, were asked to answer a questionnaire and provide blood samples following current AAS course completion. Hemoglobin, serum proteins, lipid profile and hematological parameters were measured. Meanwhile, the parameters of kidneys, liver, heart, and immune system function were monitored. RESULTS: The subjects reported taking a 3-month course of an AAS comprising three compounds (testosterone enanthate, nandrolone decanoate and methandienone). A two-week gap separated every two courses, during which tamoxifen citrate (40 mg per day) and clomiphene citrate (10 mg per day) were taken to control serum testosterone levels. The intake of AAS one course had remarkable effects on some parameters related to kidney function. However, AAS three courses or more treatments showed abnormal liver and heart enzymes. Moreover, endogenous testosterone levels decreased dramatically with prolonged use of AAS (more than 10 courses). Alpha 2 protein increased by taking more than 10 courses, which might cause acute phase reactant of liver infection or inflammation. CONCLUSIONS: AAS products must be controlled by Saudi ministry of health and should not be taken randomly without the supervision of the healthcare professional.


Assuntos
Anabolizantes/efeitos adversos , Metandrostenolona/efeitos adversos , Decanoato de Nandrolona/efeitos adversos , Testosterona/análogos & derivados , Adulto , Atletas , Estudos Transversais , Humanos , Masculino , Projetos Piloto , Arábia Saudita , Inquéritos e Questionários , Testosterona/efeitos adversos
12.
Drug Test Anal ; 11(1): 8-26, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30488582

RESUMO

A number of high profile revelations concerning anti-doping rule violations over the past 12 months have outlined the importance of tackling prevailing challenges and reducing the limitations of the current anti-doping system. At this time, the necessity to enhance, expand, and improve analytical test methods in response to the substances outlined in the World Anti-Doping Agency (WADA) Prohibited List represents an increasingly crucial task for modern sports drug testing programs. The ability to improve analytical testing methods often relies on the expedient application of novel information regarding superior target analytes for sports drug testing assays, drug elimination profiles, and alternative sample matrices, together with recent advances in instrumental developments. This annual banned-substance review evaluates literature published between October 2017 and September 2018 offering an in-depth evaluation of developments in these arenas and their potential application to substances reported in WADA's 2018 Prohibited List.


Assuntos
Doping nos Esportes/prevenção & controle , Substâncias para Melhoria do Desempenho/análise , Detecção do Abuso de Substâncias/métodos , Anabolizantes/efeitos adversos , Anabolizantes/análise , Ansiolíticos/efeitos adversos , Ansiolíticos/análise , Doping nos Esportes/tendências , Eritropoetina/efeitos adversos , Eritropoetina/análise , Humanos , Substâncias para Melhoria do Desempenho/efeitos adversos , Esportes/normas , Esportes/tendências , Detecção do Abuso de Substâncias/tendências
13.
Scand J Med Sci Sports ; 29(3): 422-429, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30387184

RESUMO

Disturbed shear rate (SR), characterized by increased retrograde and oscillatory SR in the brachial artery, is associated with inflammation, atherosclerosis, endothelial dysfunction, and sympathetic hyperactivity. Young subjects do not have disturbed SR; however, elderly subjects do, which seems to be associated with sympathetic hyperactivity. Anabolic androgenic steroids (AAS) abuse in young is associated with increased muscle sympathetic nerve activity (MSNA). We hypothesized that AAS users might have disturbed SR. We tested the association between retrograde and oscillatory SR with MSNA. In addition, we measured the high-sensitivity C-reactive protein (hs-CRP). We evaluated 10 male AAS users, age 27 ± 4 years, and 10 age-matched AAS nonusers, age 29 ± 5 years. At rest, retrograde and oscillatory SR were evaluated by Doppler ultrasound, MSNA was measured with microneurography, and hs-CRP was measured in blood sample. Flow-mediated dilation (FMD) was also assessed. AAS users had higher retrograde SR (24.42 ± 17.25 vs 9.15 ± 6.62 s- 1 , P = 0.01), oscillatory SR (0.22 ± 0.13 vs 0.09 ± 0.07 au P = 0.01), and MSNA (42 ± 9 vs 32 ± 4 bursts/100 heart beats, P = 0.018) than nonusers. MSNA (bursts/100 heart beats) was correlated with retrograde SR (r = 0.50, P = 0.050) and oscillatory SR (r = 0.51, P = 0.042). AAS users had higher hs-CRP [1.17 (0.44-3.63) vs 0.29 (0.17-0.70) mg/L, P = 0.015] and decreased FMD (6.42 ± 2.07 vs 8.28% ± 1.53%, P = 0.035) than nonusers. In conclusion, AAS abuse is associated with retrograde and oscillatory SR which were associated with augmented sympathetic outflow. In addition, AAS seems to lead to inflammation characterized by increased hs-CRP. These alterations may have the potential of increasing the early risk of atherosclerotic disease in young AAS users.


Assuntos
Anabolizantes/efeitos adversos , Artéria Braquial/fisiopatologia , Esteroides/efeitos adversos , Transtornos Relacionados ao Uso de Substâncias/fisiopatologia , Adulto , Aterosclerose , Proteína C-Reativa/análise , Estudos de Casos e Controles , Estudos Transversais , Frequência Cardíaca , Humanos , Masculino , Oscilometria , Fatores de Risco , Sistema Nervoso Simpático , Adulto Jovem
14.
Burns ; 45(4): 891-897, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30545697

RESUMO

The benefits of oxandrolone in burn patients has led to its accepted use in the burn care community, however details regarding the most common adverse effect, transaminitis, remains unclear. The purpose of this study was to determine the incidence of transaminitis in patients with burn injury and identify risk factors associated with the development of transaminitis. This single-center, retrospective risk factor analysis compared burn patients on oxandrolone with and without the development of transaminitis, defined as any aspartate aminotransferase or alanine aminotransferase value >100mg/dL. Patient demographics, past medical history, lab values, and burn characteristics were recorded. Overall 28 out of 66 (42%) patients developed transaminitis. The transaminitis group had a significantly higher proportion of other concomitant medications with a transaminitis risk (p=0.045). No significant difference in liver dysfunction or length of stay was observed between the two groups. Oxandrolone induced transaminitis is occurring in patients significantly more frequently than previously reported warranting further research to guide monitoring requirements, use of concomitant medications, and to determine if rechallenging after resolution should be considered.


Assuntos
Anabolizantes/efeitos adversos , Queimaduras/terapia , Doença Hepática Induzida por Substâncias e Drogas/epidemiologia , Oxandrolona/efeitos adversos , Adulto , Alanina Transaminase/sangue , Fosfatase Alcalina/sangue , Aspartato Aminotransferases/sangue , Bilirrubina/sangue , Doença Hepática Induzida por Substâncias e Drogas/sangue , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Feminino , Hidratação , Mortalidade Hospitalar , Humanos , Incidência , Coeficiente Internacional Normatizado , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Ressuscitação , Estudos Retrospectivos , Fatores de Risco
15.
Subst Use Misuse ; 54(5): 779-786, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30572768

RESUMO

BACKGROUND: Reports indicate that 4% of the adolescent males in 2015 had taken steroids without a doctor's prescription. Anabolic-androgenic steroids (AAS) are illicit drugs that have commonly been used to help build muscle mass. AAS use is associated with negative biological, psychological, and social side effects including substance use, suicidal behavior, and violent behavior. OBJECTIVES: This exploratory study, guided by an integrated theoretical framework that included the General Aggression Model and the Biopsychosocial Model, examined the relationship between adolescent male AAS use and teen dating violence. METHODS: This cross-sectional, secondary data analysis was conducted using the 2013 and 2015 Massachusetts Youth Health Survey (MYHS). Participants were high school-aged males with a total sample of 2,080. Primary data analysis was conducted using hierarchical logistic regression. RESULTS: Findings suggested that adolescent males who used steroids at least once in their lifetime, compared to those who did not, had greater odds of engaging in teen dating violence. Further, males who identified as a sexual minority had greater odds of using anabolic-androgenic steroids, as were those who had at least one suicide attempt in the previous 12 months. CONCLUSIONS: Adolescent male AAS use is associated with multiple psychosocial factors that practitioners, school personnel, and parents must be aware of.


Assuntos
Agressão/fisiologia , Anabolizantes/efeitos adversos , Violência por Parceiro Íntimo/psicologia , Transtornos Relacionados ao Uso de Substâncias/psicologia , Congêneres da Testosterona/efeitos adversos , Adolescente , Comportamento do Adolescente/psicologia , Estudos Transversais , Humanos , Masculino , Massachusetts
16.
Can J Physiol Pharmacol ; 97(2): 130-139, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30562047

RESUMO

Despite the chronic effects of nandrolone decanoate (ND), the acute effects of ND on passive avoidance learning (PAL) and memory and its mechanism have not been investigated. This research examines the acute effect of ND on PAL, CA1 synaptic plasticity, testosterone and corticosterone serum levels, and the role of androgenic receptors (ARs). Adolescent male rats were treated with ND, 30 min before training and retention and after training test. AR antagonist was applied 15 min before ND. Hippocampal slices were perfused by ND. ND administration had an inverted U-shape effect on acquisition of PAL and on testosterone and corticosterone serum levels. The consolidation was only affected by high dose of ND. ND significantly decreased the retention of PAL across all doses. The magnitude of field excitatory postsynaptic potential long term potentiation was lower than that of control slices. In addition, an attenuation of field excitatory postsynaptic potential population spike coupling was also observed. Nilutamide could nullify the ND impairment effect. We concluded although a single dose of ND could affect all stages of PAL, its effects were more potent on retrieval, possibly arising from the acute effect of ND on the alterations of CA1 synaptic plasticity. In addition, ND may induce its effects directly through ARs and indirectly through plasma testosterone and corticosterone.


Assuntos
Anabolizantes/efeitos adversos , Aprendizagem da Esquiva/efeitos dos fármacos , Região CA1 Hipocampal/efeitos dos fármacos , Potenciação de Longa Duração/efeitos dos fármacos , Decanoato de Nandrolona/efeitos adversos , Anabolizantes/administração & dosagem , Animais , Comportamento Animal/efeitos dos fármacos , Região CA1 Hipocampal/fisiologia , Relação Dose-Resposta a Droga , Potenciais Pós-Sinápticos Excitadores/efeitos dos fármacos , Masculino , Modelos Animais , Decanoato de Nandrolona/administração & dosagem , Ratos , Ratos Wistar , Receptores Androgênicos/metabolismo
17.
Artigo em Espanhol | LILACS | ID: biblio-1048475

RESUMO

La rotura bilateral y simultánea del tendón cuadricipital es una lesión rara con pocos reportes en la literatura, que suele ocurrir en mayores de 50 años con enfermedades sistémicas crónicas subyacentes. Presentamos el caso de un paciente masculino sano de 32 años con rotura bilateral de tendón cuadricipital durante la práctica de musculación asociada a la administración de anabolizantes esteroideos y el tratamiento realizado


Bilateral and simultaneous rupture of the quadriceps tendon is a rare injury with a few reports in record that usually occurs in people older than 50 years with underlying chronic systemic diseases. We present the case of a healthy 32-year-old male patient with bilateral quadriceps tendon rupture during weight training practice associated to anabolic steroids administration and the treatment provided


Assuntos
Adulto , Traumatismos dos Tendões/cirurgia , Transtornos Relacionados ao Uso de Substâncias/complicações , Músculo Quadríceps/lesões , Anabolizantes/efeitos adversos , Traumatismos do Joelho/patologia , Ruptura , Levantamento de Peso/lesões
19.
Semin Thromb Hemost ; 44(8): 734-746, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30267392

RESUMO

Anabolic androgenic steroid (AAS) abuse surged during the 1980s and is seen in approximately 1 in 20 of all males today. A wide spectrum of AAS compounds and abuse regimens are applied and AAS abuse has been associated with an unfavorable cardiovascular profile. The aim of this review is to critique the collected data concerning effects of AAS abuse on thrombosis risk through presentation of condensed evidence from studies investigating AAS-induced changes in coagulation, fibrinolysis, and cardiovascular risk markers. AAS abuse inflicts a procoagulant distribution of cardiovascular risk markers including dyslipidemia and atherosclerosis proneness. AAS abuse overall stimulates synthesis of coagulation factors, inhibitors, and fibrinolytic proteins resulting in both increased global coagulation and stimulation of fibrinolysis. Overall, supported by many case reports and some epidemiological studies, AAS abuse is associated with an increased risk of thrombosis. However, to provide clear evidence for a causal relationship between AAS abuse and thrombosis risk, future studies need to address a range of potential biases, insufficient methodology, and other shortcomings of the current literature as highlighted in this review.


Assuntos
Anabolizantes/efeitos adversos , Doping nos Esportes , Esteroides/efeitos adversos , Transtornos Relacionados ao Uso de Substâncias/fisiopatologia , Coagulação Sanguínea/efeitos dos fármacos , Doenças Cardiovasculares/induzido quimicamente , Fibrinólise/efeitos dos fármacos , Humanos , Fatores de Risco , Trombose/induzido quimicamente
20.
Can J Cardiol ; 34(10): 1369.e1-1369.e3, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30205989

RESUMO

A 39-year-old male weightlifter presented in fulminant heart failure. An echocardiogram revealed severe global biventricular failure. Left ventricular (LV) systolic function was estimated at 15%. His dilated cardiomyopathy was attributed to his use of both testosterone and boldenone in the 3-month period before his presentation. Although the deleterious effects of androgenic- anabolic steroids on diastolic function are well known, the effects of these drugs on systolic function is an area of ongoing investigation. Our case suggests that androgenic anabolic steroid use should be considered in the differential diagnosis of patients presenting with acute heart failure.


Assuntos
Anabolizantes/efeitos adversos , Androgênios/efeitos adversos , Insuficiência Cardíaca/induzido quimicamente , Esteroides/efeitos adversos , Doença Aguda , Adulto , Biópsia , Combinação de Medicamentos , Ecocardiografia , Eletrocardiografia , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/fisiopatologia , Humanos , Imagem Cinética por Ressonância Magnética , Masculino
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA