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4.
J Dermatol ; 45(12): 1459-1462, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30320485

RESUMO

Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue, resulting in macular atrophy or herniated saclike skin. Some families with hereditary anetoderma have been described, but there have been no reports on Japanese familial anetoderma so far. We herein report two Japanese sibling cases of primary anetoderma. A healthy 13-year-old Japanese girl and a healthy 15-year-old Japanese girl presented to our hospital with a 6-month history of small atrophic pittings on their arms and trunks. All lesions were less than 0.5 cm in diameter, which are relatively small for non-familial anetoderma. Preceding infections or skin lesions were not observed. A skin biopsy revealed a focal, complete loss of elastic tissue in the superficial to mid-dermis which was surrounded by fine, irregular or twisted elastic fibers. Based on these findings, the diagnosis of anetoderma was made. Review of published works demonstrated that the mode of inheritance of familial anetoderma is not simple, suggesting that it is important to survey any family member of the patients with anetoderma.


Assuntos
Anetodermia/diagnóstico , Anamnese , Herança Multifatorial , Doenças Raras/diagnóstico , Adolescente , Anetodermia/genética , Anetodermia/patologia , Biópsia , Feminino , Humanos , Japão , Doenças Raras/genética , Doenças Raras/patologia , Pele/patologia
5.
Pediatr Dermatol ; 35(6): e416-e417, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30152553

RESUMO

A 15-month-old boy presented with 1-4 cm, pink edematous plaques with overlying round erosions and hemorrhagic bullae in the setting of a gastrointestinal illness and was ultimately diagnosed with bullous-type Sweet syndrome. Despite appropriate treatment with oral steroids, the patient's cutaneous lesions healed with secondary anetoderma. This case should prompt practitioners to be aware of bullous-type Sweet syndrome and the possibility of lesions healing with postinflammatory scarring.


Assuntos
Anetodermia/etiologia , Síndrome de Sweet/diagnóstico , Anetodermia/patologia , Glucocorticoides/uso terapêutico , Humanos , Lactente , Masculino , Prednisolona/uso terapêutico , Pele/patologia , Síndrome de Sweet/complicações , Síndrome de Sweet/tratamento farmacológico , Cicatrização
7.
J Dtsch Dermatol Ges ; 16(2): 183-191, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29418081

RESUMO

Along with collagen, elastic fibers are integral components of cutaneous connective tissue. A decrease in elastic fibers or loss thereof has been described in a number of clinically distinct skin diseases, both hereditary and acquired. In disorders associated with inflammation, elastophagocytosis is an important histological hallmark. Treatment is generally difficult.


Assuntos
Tecido Elástico/patologia , Dermatopatias/patologia , Pele/patologia , Anetodermia/diagnóstico , Anetodermia/patologia , Anetodermia/terapia , Cútis Laxa/diagnóstico , Cútis Laxa/patologia , Cútis Laxa/terapia , Granuloma de Células Gigantes , Humanos , Ceratodermia Palmar e Plantar/diagnóstico , Ceratodermia Palmar e Plantar/patologia , Ceratodermia Palmar e Plantar/terapia , Linfoma Cutâneo de Células T/diagnóstico , Linfoma Cutâneo de Células T/patologia , Linfoma Cutâneo de Células T/terapia , Pseudoxantoma Elástico , Dermatopatias/diagnóstico , Dermatopatias/terapia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/terapia
9.
J Cutan Pathol ; 44(9): 786-789, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28605051

RESUMO

Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue due to unknown mechanisms. Primary anetoderma develops on clinical normal skin, without any preceding dermatosis and it can be associated with autoimmune conditions. Secondary anetoderma develops on the same area of a previous disorder, such as infectious, neoplastic or inflammatory diseases. A 37-year-old female patient noticed for 4 years circumscribed, normochromic, asymptomatic herniated plaques on the trunk and upper limbs. Family history was negative. Only a positive antinuclear factor (ANF) test, with titer of 1:160 and nuclear homogeneous pattern was found. Light microscopy with Weigert staining showed a lessening of elastic fibers with fragmentation; the oxytalanic fibers were also affected or absent. Transmission electron microscopy showed fragmentation and granular degeneration of elastic fibers. With greater magnification, fragments similar to those seen with optical microscopy were identified. The collagen fibers did not present any alteration. The examination of the dermis with scanning electron microscopy also identified fragmentation and significant fissures of the elastic tissue, granular degeneration was also observed. With greater magnification fragmented elastic fibers were seen.


Assuntos
Anetodermia/patologia , Adulto , Feminino , Humanos , Microscopia Eletrônica , Pele/patologia , Pele/ultraestrutura
11.
Int J STD AIDS ; 28(14): 1456-1460, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28571518

RESUMO

Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature, the pathogenesis is still poorly determined. Anetoderma in syphilis is rare, and occurs even in the most uncommon cutaneous manifestations of the disease, such as the nodular form. In order to better understand the changes that lead to elastolysis, we propose a better correlation with the histopathological findings of the lesions that precede it. We present two cases of anetoderma secondary to syphilis, whose clinical aspects resembled the pattern of their initial secondary syphilis rash.


Assuntos
Anetodermia/tratamento farmacológico , Anetodermia/etiologia , Tecido Elástico/patologia , Penicilina G Benzatina/uso terapêutico , Sífilis/complicações , Adulto , Anetodermia/diagnóstico , Anetodermia/patologia , Biópsia , Feminino , Humanos , Penicilina G Benzatina/efeitos adversos , Pele/patologia , Dermatopatias , Sífilis/patologia , Terapêutica
12.
Dermatol Online J ; 23(3)2017 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-28329518

RESUMO

INTRODUCTION: Anetoderma is an elastolytic skindisorder that has been associated with the presenceof antiphospholipid antibodies (aPL). Patients withantiphospholipid antibody-positive anetoderma havebeen reported to develop symptoms of Graves disease,antiphospholipid syndrome, and other autoimmuneconditions. The temporal relationship, however,between anetoderma onset and the emergence ofaPL remains unclear, a clarification of which may haveimplications for the screening and monitoring ofpatients with anetoderma. CASE: Herein we report acase of a patient with systemic lupus erythematosuspresenting with anetoderma that preceded thedevelopment of aPL. The patient was found to havesubsequently developed IgM cardiolipin antibodiesat a serology follow-up approximately two years later.Conclusion and Relevance: This finding suggests thatanetoderma can precede aPL seroconversion andthat patients with anetoderma may require continuedserology monitoring. Such long-term monitoring willbe important for identifying laboratory indicationsthat may portend the development of furtherautoimmune symptoms associated with anetoderma.


Assuntos
Anetodermia/imunologia , Anticorpos Anticardiolipina/imunologia , Imunoglobulina M/imunologia , Lúpus Eritematoso Sistêmico/imunologia , Anetodermia/complicações , Anetodermia/diagnóstico , Anetodermia/patologia , Anticorpos Antifosfolipídeos/imunologia , Cotovelo , Feminino , Humanos , Lúpus Eritematoso Sistêmico/complicações , Fatores de Tempo , Adulto Jovem
13.
14.
Dermatol Online J ; 23(12)2017 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-29447658

RESUMO

Anetoderma is a rare benign elastolytic disorder that is characterized by focal loss of elastin fibers on histopathology and is often recalcitrant to treatment. We present a case of a patient with a 20-year history of pruritic and painful hyperpigmented atrophic papules clustered on the neck, axillae, inframammary folds, and right medial thigh. Although the histopathologyof her axillary lesions was consistent with anetoderma, her clinical presentation is unusual given the extent of involvement, reported pain and pruritus, and sharp demarcation of the distribution. The diagnosticuncertainty of this case led to added difficulty in management of a disease that is already notoriously difficult to treat and may significantly impact patient's quality of life.


Assuntos
Anetodermia/diagnóstico , Doenças do Tecido Conjuntivo Indiferenciado/diagnóstico , Anetodermia/complicações , Anetodermia/patologia , Anetodermia/terapia , Diagnóstico Tardio , Feminino , Humanos , Pessoa de Meia-Idade , Doenças do Tecido Conjuntivo Indiferenciado/complicações , Doenças do Tecido Conjuntivo Indiferenciado/patologia
18.
J Cosmet Laser Ther ; 18(1): 38-40, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-25968163

RESUMO

Anetoderma is a skin disorder characterized by a focal loss of dermal elastic tissue whereby patients present with soft, depressible lesions. We postulated that a series of combination treatment using the 595-nm pulsed dye laser (PDL) and the 1550-nm non-ablative fractionated laser (NAFL) would improve the anetoderma lesions. Our patient with biopsy proven anetoderma received 3 treatments with a combination of 595-nm PDL and 1550-nm NAFL spaced 3 weeks apart. Skin biopsies were performed at baseline and immediately prior to the third treatment. Stains for hematoxylin and eosin and Verhoeff Van Gieson (VVG) were performed. Improvement in lesion color, texture, and overall appearance was noted after the second treatment and continued following the third treatment. Post-treatment VVG staining demonstrated an increase in dermal elastin fibers and a decrease in elastin fiber fragmentation. Thus, the combination of 595-nm PDL and 1550-nm NAFL should be considered as a treatment modality for anetoderma.


Assuntos
Anetodermia/radioterapia , Lasers de Corante/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Anetodermia/patologia , Elastina , Humanos , Terapia com Luz de Baixa Intensidade/métodos , Masculino , Adulto Jovem
19.
J Immunol Res ; 2016: 4325463, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-28116317

RESUMO

Background. The clinical and histopathologic classification of anetoderma are not well characterized. Objective. We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings. Methods. We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2. Results. Protruding type (n = 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type (n = 13). MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls (p < 0.05). MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue. TIMP-1 was highly expressed in anetoderma lesions and controls. TIMP-2 expression was variable. Conclusions. Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma.


Assuntos
Anetodermia/classificação , Anetodermia/patologia , Progressão da Doença , Pele/patologia , Adulto , Anetodermia/imunologia , Biomarcadores/metabolismo , Elastina/metabolismo , Feminino , Fibrilina-1/metabolismo , Humanos , Imuno-Histoquímica , Masculino , Metaloproteinase 12 da Matriz/metabolismo , Metaloproteinase 2 da Matriz/metabolismo , Metaloproteinase 7 da Matriz/metabolismo , Metaloproteinase 9 da Matriz/metabolismo , Estudos Retrospectivos , Inibidor Tecidual de Metaloproteinase-1/metabolismo , Inibidor Tecidual de Metaloproteinase-2/metabolismo , Adulto Jovem
20.
Indian J Lepr ; 88(2): 129-131, 2016 04.
Artigo em Inglês | MEDLINE | ID: mdl-29757546

RESUMO

Elastophagocytosis is the engulfment of the elastic fibres by the histiocytes, multinucleated giant cells, or both. The cutaneous lesions showing elastophagocytosis are annular elastolytic giant cell granuloma, actinic keratoses, persistent insect-bite reactions, elastosis perforans serpiginosa, foreign body granuloma. Occasionally, it may occur in infectious diseases like leprosy, granulomatous syphilis, North-American blastomycosis, bacterial folliculitis, and cutaneous leishmaniasis. We report a case of lepromatous leprosy with necrotic erythema nodosum leprosum with secondary anetoderma. Histopathology from the atrophic macule of anetoderma revealed periappendageal, perineural infiltration, elastophagocytosis and reduction in elastic fibres.


Assuntos
Tecido Elástico/metabolismo , Hanseníase Virchowiana/diagnóstico , Fagocitose , Anetodermia/diagnóstico , Anetodermia/etiologia , Anetodermia/metabolismo , Anetodermia/patologia , Tecido Elástico/patologia , Eritema Nodoso/diagnóstico , Eritema Nodoso/etiologia , Eritema Nodoso/metabolismo , Eritema Nodoso/patologia , Histiócitos/fisiologia , Humanos , Hanseníase Virchowiana/complicações , Hanseníase Virchowiana/metabolismo , Hanseníase Virchowiana/patologia , Masculino , Pessoa de Meia-Idade
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