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1.
No Shinkei Geka ; 47(2): 205-210, 2019 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-30818277

RESUMO

We present a rare case of subdural empyema with cerebral arteritis and brain ischemia in the middle cerebral artery distribution secondary to odontogenic maxillary sinusitis. A 32-year-old man was admitted to our hospital because of high fever and generalized convulsions. Computed tomography(CT)and magnetic resonance imaging(MRI)showed subdural empyema at the left convexity, with a small amount of air. An interruption of the right maxillary sinus floor corresponding to the alveolar process was evident on coronal CT. He was diagnosed as having subdural empyema caused by odontogenic maxillary sinusitis. MR angiography showed stenosis of the left middle cerebral artery(MCA). Despite antibiotic administration, he became drowsy and developed aphasia with right hemiparesis. Repeat MRI showed enlargement of the encapsulated subdural empyema with increased midline shift to the right. We performed prompt surgical evacuation with craniotomy, endoscopic drainage of the sinusitis, and tooth extraction. A hyperintense lesion was observed on subsequent diffusion-weighted imaging in the left MCA distribution. After repeat drainage of the re-enlarged subdural empyema, he was discharged without apparent neurological deficits. This case indicates that subdural empyema from odontogenic sinusitis requires a suitable imaging study of the brain, head, and neck region, and a multidisciplinary approach involving a neurosurgeon, otolaryngologist, and oral surgeon. Prompt initiation of appropriate antibiotic therapy with surgical intervention is recommended for treatment of subdural empyema from odontogenic sinusitis.


Assuntos
Arterite , Isquemia Encefálica , Empiema Subdural , Sinusite Maxilar , Levantamento do Assoalho do Seio Maxilar , Adulto , Arterite/complicações , Arterite/diagnóstico , Arterite/terapia , Empiema Subdural/complicações , Empiema Subdural/diagnóstico , Empiema Subdural/terapia , Humanos , Masculino , Artéria Cerebral Média , Tomografia Computadorizada por Raios X
2.
Am J Ophthalmol ; 200: 123-129, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30633893

RESUMO

PURPOSE: To determine whether nonarteritic ischemic optic neuropathy (NAION) raises the risk of subsequent stroke in the general population. DESIGN: Population-based, retrospective cohort study. METHODS: Setting: Nationwide, population-based, retrospective cohort study. PATIENTS: Of 1 025 340 beneficiaries in the National Health Insurance Service-National Sample Cohort database (2002-2013), we included 400 952 eligible individuals in the analysis. OBSERVATIONS: To determine the effect of incident NAION on the occurrence of subsequent stroke, we used time-varying covariate Cox regression models. Model 1 included only incident NAION as a time-varying covariate. Model 2 included Model 1 and defined demographics. Model 3 included Model 2, comorbidity, co-medication, and Charlson index score. MAIN OUTCOME MEASURES: Effect (hazard ratio [HR]) of NAION on stroke development. RESULTS: Of 400 952 eligible individuals, 1125 patients developed NAION and 16 998 patients suffered from stroke. NAION was not associated with an increased risk of subsequent stroke in Model 1, with HR of 1.31 (95% confidence interval [CI], 0.89-1.92). This was consistent, after adjusting for demographics and/or confounding factors, in Model 2 (HR = 1.19, 95% CI, 0.81-1.75) and Model 3 (HR = 1.10, 95% CI, 0.75-1.62). CONCLUSIONS: Our results suggest that NAION per se is not associated with a subsequent risk of stroke in the general population.


Assuntos
Neuropatia Óptica Isquêmica/complicações , Acidente Vascular Cerebral/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Arterite/complicações , Estudos de Coortes , Bases de Dados Factuais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Programas Nacionais de Saúde/estatística & dados numéricos , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Fatores de Risco
3.
Rev. iberoam. micol ; 35(3): 159-161, jul.-sept. 2018. ilus
Artigo em Inglês | IBECS | ID: ibc-179578

RESUMO

Background: T2 magnetic resonance imaging (T2MR) is a new method for the diagnosis of invasive candidiasis, although most studies have analyzed its role in patients with candidemia or not infection. Case report: We present the case of a patient with arteritis and thrombosis of the hepatic graft resulted from an undocumented fungal infection in the explanted liver.T2MR in serum was a suitable diagnostic tool for the diagnosis of the deep-seated invasive candidiasis in the absence of candidemia or the isolation of the yeast in culture. Conclusions: T2MR allowed the diagnosis of deep-seated invasive candidiasis in an immunodepressed patient without candidemia, even before the onset of symptoms


Antecedentes: La técnica T2 de visualización en resonancia magnética (T2MR, por su abreviatura en inglés) es un método nuevo de diagnóstico de candidiasis invasora, si bien la mayoría de los estudios la ha validado en casos de candidemia o cuando no hay infección. Caso clínico: Se presenta el caso de una paciente con arteritis y trombosis de la arteria hepática en el injerto secundarias a una infección profunda por Candida en el hígado explantado. La positividad de la técnica T2MR en suero constituyó la única evidencia de infección profunda por Candida en ausencia de candidemia o existencia de la levadura en cultivo. Conclusiones: La técnica T2MR permitió el diagnóstico de una infección profunda por Candida en una paciente inmunodeprimida en una fase muy precoz de la enfermedad


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Espectroscopia de Ressonância Magnética/métodos , Candida/isolamento & purificação , Candidíase Invasiva/diagnóstico por imagem , Transplante de Fígado/efeitos adversos , Trombose/complicações , Hospedeiro Imunocomprometido , Complicações Pós-Operatórias , Arterite/complicações
4.
Eur Ann Otorhinolaryngol Head Neck Dis ; 135(6): 449-451, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30072286

RESUMO

INTRODUCTION: Neurological complications of acute sinusitis are exceptional, but potentially serious. CASE REPORT: The authors report the case of a 6-year-old diabetic girl who presented with middle cerebral artery ischemic stroke secondary to inflammatory arteritis of the left internal carotid artery in a context of bilateral acute maxillary sinusitis. MRI confirmed ischaemic stroke associated with carotid arteritis and complete obstruction of the maxillary sinuses. A favourable outcome was observed after endoscopic drainage of the sinuses associated with broad-spectrum antibiotic therapy. DISCUSSION: This complication was probably due to spread of an infectious inflammatory reaction of the intrapetrosal carotid artery and its branches via the pterygoid venous plexus. To our knowledge, this is the first published case report of maxillary sinusitis complicated by stroke.


Assuntos
Arterite/complicações , Doenças das Artérias Carótidas/complicações , Infarto da Artéria Cerebral Média/etiologia , Sinusite Maxilar/complicações , Artéria Carótida Interna , Criança , Feminino , Humanos , Infarto da Artéria Cerebral Média/diagnóstico por imagem , Imagem por Ressonância Magnética , Sinusite Maxilar/diagnóstico por imagem
5.
Australas J Dermatol ; 59(3): 223-225, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29624649

RESUMO

Lymphocytic thrombophilic arteritis (LTA) is a recently described entity defined by primary lymphocytic vasculitis; it typically has a chronic indolent course. We describe a patient who presented with clinical and histological findings consistent with LTA and later developed bilateral focal testicular infarcts as well as an acute median nerve neuropathy.


Assuntos
Arterite/complicações , Infarto/etiologia , Livedo Reticular/complicações , Testículo/irrigação sanguínea , Trombofilia/complicações , Adulto , Arterite/tratamento farmacológico , Humanos , Livedo Reticular/tratamento farmacológico , Livedo Reticular/patologia , Linfócitos , Masculino , Neuropatia Mediana , Mononeuropatias/etiologia , Trombofilia/tratamento farmacológico
6.
Clin Neurol Neurosurg ; 169: 103-106, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29653415

RESUMO

OBJECTIVE: To present and review the vascular consequences of arteritis in neurosarcoidosis. PATIENT AND METHODS: neurosarcoidosis is typically an inflammatory disorder of the meninges surrounding the brain and spinal cord. Although inflammation of small and medium sized vessels is seen pathologically and vasculitis is occasionally described, a large intracerebral arteritis has not previously been reported. A few case reports exist, however, which describe the vascular consequences of large vessel compromise in the disorder. We review the literature and present a new case with novel MRI features which imply carotid arteritis. RESULTS: The case presented with a disorder of the carotid artery on one side leading to a series of TIAs. Inflammation of the wall of the carotid artery was seen adjacent to a granulomatous leptomeningitis. The disorder responded to immunosuppressive therapy without recurrence. CONCLUSIONS: The imaging features suggest a granulomatous infiltration of the carotid artery wall leading to arteritis followed by disorganisation of the internal elastic lamina and fibrosis. The data provide further insight into the pathogenesis of neurological impairments in neurosarcoidosis. The MRI features of carotid arteritis in neurosarcoidosis have not previously been demonstrated.


Assuntos
Amaurose Fugaz/diagnóstico por imagem , Arterite/diagnóstico por imagem , Artéria Carótida Interna/diagnóstico por imagem , Doenças do Sistema Nervoso Central/diagnóstico por imagem , Ataque Isquêmico Transitório/diagnóstico por imagem , Sarcoidose/diagnóstico por imagem , Amaurose Fugaz/etiologia , Arterite/complicações , Doenças do Sistema Nervoso Central/complicações , Humanos , Ataque Isquêmico Transitório/etiologia , Masculino , Pessoa de Meia-Idade , Sarcoidose/complicações
7.
Australas J Dermatol ; 59(2): e127-e132, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-28752544

RESUMO

We describe three patients who presented with a striking erythematous non-blanching annular eruption and features of lymphocytic thrombophilic arteritis (LTA), with a prominent lymphocytic vasculitis involving deep dermal vessels. Lymphocytic inflammation was also evident in the superficial vessels and one patient had small superficial ulcers over the ankle area resembling livedoid vasculopathy (LV). Multiple biopsies demonstrated a persistent absence of neutrophils in the infiltrate consistent with a lymphocytic process. In addition to highlighting the annular morphology as a novel presentation of LTA, these cases suggest a possible relationship between LV and LTA and support the notion that they are distinct from neutrophilic vasculitides such as cutaneous polyarteritis nodosa.


Assuntos
Arterite/complicações , Dermatopatias/etiologia , Trombofilia/complicações , Adulto , Arterite/tratamento farmacológico , Arterite/patologia , Aspirina/uso terapêutico , Feminino , Fibrinolíticos/uso terapêutico , Humanos , Linfócitos , Pessoa de Meia-Idade , Pentoxifilina/uso terapêutico , Inibidores da Agregação de Plaquetas/uso terapêutico , Trombofilia/tratamento farmacológico , Trombofilia/patologia
9.
Graefes Arch Clin Exp Ophthalmol ; 255(11): 2255-2261, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28861697

RESUMO

PURPOSE: The purpose of our study was to describe the feature of acute non-arteritic or arteritic anterior ischemic optic neuropathy (NA-AION and A-AION) using optical coherence tomography angiography (OCT-A) and to compare it with fluorescein angiography (FA) and indocyanine green angiography (ICGA). METHODS: In this retrospective, observational case-control study four NA-AION patients and one A-AION patient were examined by FA, ICGA and OCT-A within 2 weeks from disease presentation. The characteristics of the images were analyzed. Optic nerve head (ONH) and radial peripapillary capillaries (RPC) vessel densities (VDs) were compared between NA-AION and controls. RESULTS: In two of four NA-AION cases and in the A-AION patient, OCT-A clearly identified the boundary of the ischemic area at the level of the optic nerve head, which was comparable to optic disc filling defects detected by FA. In the other two NA-AION cases, a generalized leakage from the disc was visible with FA, yet OCT-A still demonstrated sectorial peripapillary capillary network reduction. Both ONH and RPC VDs were reduced in NA-AION patients, when compared to controls. CONCLUSIONS: OCT-A was able to identify microvascular defects and VD reduction in cases of acute optic disc edema due to NA-AION and A-AION. OCT-A provides additional information in ischemic conditions of the optic nerve head.


Assuntos
Arterite/complicações , Angiofluoresceinografia/métodos , Disco Óptico/patologia , Neuropatia Óptica Isquêmica/diagnóstico , Vasos Retinianos/patologia , Tomografia de Coerência Óptica/métodos , Doença Aguda , Idoso , Idoso de 80 Anos ou mais , Arterite/diagnóstico , Estudos de Casos e Controles , Feminino , Seguimentos , Fundo de Olho , Humanos , Masculino , Microvasos/patologia , Disco Óptico/irrigação sanguínea , Neuropatia Óptica Isquêmica/etiologia , Estudos Retrospectivos , Fatores de Tempo
10.
Intern Med ; 56(18): 2445-2450, 2017 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-28824056

RESUMO

Immunoglobulin G4 (IgG4)-related disease is a systemic inflammatory disorder that was first described in patients with autoimmune pancreatitis. Although IgG4-related disease is thought to involve the cardiovascular system, case reports describing coronary artery involvement are relatively rare. We describe a patient who was previously diagnosed with autoimmune pancreatitis and found to have coronary periarteritis and luminal narrowing. After the initiation of steroid treatment, the patient's coronary periarteritis and luminal stenosis were both ameliorated with an improvement in the serum IgG4 concentration. The present findings collectively suggest that IgG4-related immuno-inflammation may have a role in the development of coronary periarteritis and luminal atherosclerosis.


Assuntos
Arterite/complicações , Doenças Autoimunes/complicações , Doença da Artéria Coronariana/complicações , Imunoglobulina G/imunologia , Pancreatite/complicações , Corticosteroides/uso terapêutico , Idoso , Arterite/tratamento farmacológico , Arterite/imunologia , Doenças Autoimunes/tratamento farmacológico , Doenças Autoimunes/imunologia , Constrição Patológica , Doença da Artéria Coronariana/tratamento farmacológico , Doença da Artéria Coronariana/imunologia , Humanos , Inflamação , Masculino , Pancreatite/imunologia
11.
Invest Ophthalmol Vis Sci ; 58(10): 4286-4291, 2017 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-28846776

RESUMO

Purpose: We hypothesized that the edema/swelling in the retina due to acute nonarteritic anterior ischemic optic neuropathy (NAION) can induce retinal folds (RF). We determined the pattern and frequency of folds in NAION at presentation and in follow-up, and the relationship between folds and a number of functional and structural parameters over time. Methods: We prospectively studied eyes with acute NAION by spectral-domain optic coherence tomography (SD-OCT). We used transaxial and en face views to evaluate the presence of peripapillary fluid (PPF), peripapillary wrinkles (PPW), RF, choroidal folds (CF), creases, macular edema, and vitreous traction on the optic disc. Retinal deformations were correlated with the retinal nerve fiber layer (RNFL) thickness, logMAR visual acuity (VA) and mean deviation (MD). Results: At presentation, 60 eyes had mean RNFL = 224 ± 75 µm, no vitreous traction, and similar VA and MD regardless of the retinal deformation or macular edema. There was PPF in 73%, PPW in 57%, RF in 38%, creases in 20%, and macular edema in 18% of eyes, and no CF. Eyes with retinal deformations had significantly greater RNFL thickness (P< 0.026). At 1 to 2 months, 49 eyes had reduction of the RNFL (112 ± 40 µm, P = 0.001) and unchanged VA and MD that did not correlate with fewer eyes having PPF (15%, P = 0.001), PPW (10%, P = 0.001), RF (10%, P = 0.001), creases (17%), and macular edema (0%, P = 0.007). Conclusions: RF in NAION reflect stresses and strains due to extracellular fluid without increased pressure in the retrolaminar tissue and subarachnoid space, seen with papilledema. In NAION, the deformations and their resolution do not correlate with vision loss.


Assuntos
Edema Macular/etiologia , Neuropatia Óptica Isquêmica/complicações , Doenças Retinianas/etiologia , Doença Aguda , Arterite/complicações , Doenças da Coroide/etiologia , Doenças da Coroide/fisiopatologia , Feminino , Humanos , Edema Macular/fisiopatologia , Masculino , Pessoa de Meia-Idade , Fibras Nervosas/patologia , Disco Óptico/patologia , Neuropatia Óptica Isquêmica/fisiopatologia , Estudos Prospectivos , Doenças Retinianas/fisiopatologia , Células Ganglionares da Retina/patologia , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia
12.
BMJ Case Rep ; 20172017 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-28663358

RESUMO

A 56-year-old woman presented with acute onset of typical chest pain. She was diagnosed with acute coronary syndrome with ST-segment elevation myocardial infarction. Although significant obstructive coronary artery disease was ruled out by coronary angiography, cardiac MRI showed transmural necrosis of the lateral free wall with extensive microvascular obstruction consistent with ischaemic heart disease. Within 48 hours after initial presentation, the patient suddenly arrested due to pulseless electrical activity with futile resuscitation efforts. Autopsy revealed myocardial perforation with extensive haematothorax due to pericardial laceration, caused by the mechanical chest compressions. Eventually, histology identified diffuse necrotising coronary vasculitis as a rare cause of ischaemic heart disease.


Assuntos
Síndrome Coronariana Aguda/etiologia , Arterite/complicações , Vasos Coronários/patologia , Parada Cardíaca/etiologia , Infarto do Miocárdio/etiologia , Arterite/patologia , Evolução Fatal , Feminino , Hemotórax , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Isquemia Miocárdica/etiologia , Miocárdio/patologia , Necrose/etiologia , Pericárdio/lesões , Ressuscitação
13.
Rinsho Shinkeigaku ; 57(6): 307-310, 2017 06 28.
Artigo em Japonês | MEDLINE | ID: mdl-28552872

RESUMO

A 55-year-old man was admitted with paralysis of the left lower leg. He had purpura in the left lower extremity for three years, left calf pain for two years, and dysesthesia in the left plantar region and first toe for one year. A physical examination revealed livedo reticularis on the left leg and mononeuritis multiplex was diagnosed in the bilateral tibial and left peroneal nerve area. Anti-neutrophil cytoplasmic antibody was negative. A nerve conduction study showed decreased amplitude of compound muscle-action potential in the bilateral tibial and the left peroneal nerve, sensory nerve action potential in the bilateral sural nerve. A skin biopsy revealed inflammatory cells on blood vessel walls and cutaneous arteritis was diagnosed. Cyclophosphamide pulse therapy with steroid and anti-coagulation improved the neurological symptoms. A skin biopsy should be considered when patients present with mononeuritis multiplex in the lower extremities and cutaneous findings such as livedo reticularis in the symptomatic area.


Assuntos
Arterite/complicações , Biópsia , Mononeuropatias/diagnóstico , Mononeuropatias/etiologia , Pele/irrigação sanguínea , Pele/patologia , Anticoagulantes/administração & dosagem , Arterite/tratamento farmacológico , Arterite/patologia , Ciclofosfamida/administração & dosagem , Diagnóstico Diferencial , Humanos , Masculino , Metilprednisolona/administração & dosagem , Pessoa de Meia-Idade , Mononeuropatias/tratamento farmacológico , Mononeuropatias/patologia , Prednisolona/administração & dosagem , Pulsoterapia , Resultado do Tratamento
14.
Clin Chim Acta ; 471: 76-80, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28526535

RESUMO

BACKGROUND: Tumor necrosis factor (TNF) -α is of inflammatory cytokines produced chiefly by activated monocyte/macrophages, and has been implicated in the pathogenesis of Kawasaki disease (KD). We elucidated the relationship of plasma TNF-α with conventional inflammatory mediators, clinical classification, intravenous immunoglobulin (IVIG) response and coronary arteritis in the course of KD. METHODS: Seventy Chinese children with KD were enrolled and divided into 6 subgroups, including complete KD, incomplete KD, IVIG-responsive KD, IVIG-nonresponsive KD, coronary artery (CA) -noninvolvement KD and CA-involvement KD. Blood samples were collected from all subjects at 24h pre- and 48h post-IVIG therapy, respectively. TNF-α, white blood cells counts (WBC), absolute neutrophil counts (ANC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and procalcitonin (PCT) were detected. RESULTS: Plasma TNF-α markedly increased in the acute phase of KD and was positively correlated with CRP and PCT, whereas remained high after IVIG therapy. TNF-α as well as conventional inflammatory mediators could not be used to differentiate the clinical classification of KD, but they may prove beneficial to heighten or reduce the suspicion of incomplete KD. Plasma TNF-α was significantly higher in both IVIG-nonresponsive patients and coronary arteritis patients, but no significant differences were observed in all the other inflammatory mediators. Moreover, plasma TNF-α was positively correlated with the internal diameter of CA. CONCLUSIONS: TNF-α is superior to conventional inflammatory mediators in forecasting IVIG nonresponse and coronary arteritis in Chinese children with KD.


Assuntos
Arterite/complicações , Doença da Artéria Coronariana/complicações , Imunoglobulinas Intravenosas/uso terapêutico , Mediadores da Inflamação/sangue , Síndrome de Linfonodos Mucocutâneos/sangue , Síndrome de Linfonodos Mucocutâneos/tratamento farmacológico , Fator de Necrose Tumoral alfa/sangue , Arterite/diagnóstico , Pré-Escolar , Doença da Artéria Coronariana/diagnóstico , Feminino , Humanos , Masculino , Síndrome de Linfonodos Mucocutâneos/complicações , Prognóstico , Resultado do Tratamento
17.
BMC Neurol ; 17(1): 33, 2017 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-28209139

RESUMO

BACKGROUND: Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through increased susceptibility or direct induction. CASE PRESENTATION: A 46-year-old Chinese male initially presented with fever, headache, and impaired memory and developed disturbance of consciousness after admission. A clinical diagnosis of Staphylococcus aureus sepsis, massive cerebral infarction and haemorrhagic transformation (left internal carotid arterial system, inflammatory thrombus) were made based on brain radiography, blood culture and postoperative pathological examinations. These symptoms improved following antibiotic therapy with vancomycin and conventional treatments for stroke. CONCLUSION: For stroke patients without traditional cerebrovascular risk factors but with signs of infection, infectious causes should be considered.


Assuntos
Arterite/complicações , Trombose das Artérias Carótidas/complicações , Acidente Vascular Cerebral/etiologia , Infarto Cerebral/complicações , Humanos , Masculino , Pessoa de Meia-Idade
18.
Eur J Nucl Med Mol Imaging ; 44(1): 141-150, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27738728

RESUMO

PURPOSE: It remains unclear whether changes in arterial wall inflammation are associated with subsequent changes in the rate of structural progression of atherosclerosis. METHODS: In this sub-study of the dal-PLAQUE clinical trial, multi-modal imaging was performed using 18-fludeoxyglucose (FDG) positron emission tomography (PET, at 0 and 6 months) and magnetic resonance imaging (MRI, at 0 and 24 months). The primary objective was to determine whether increasing FDG uptake at 6 months predicted atherosclerosis progression on MRI at 2 years. Arterial inflammation was measured by the carotid FDG target-to-background ratio (TBR), and atherosclerotic plaque progression was defined as the percentage change in carotid mean wall area (MWA) and mean wall thickness (MWT) on MRI between baseline and 24 months. RESULTS: A total of 42 participants were included in this sub-study. The mean age of the population was 62.5 years, and 12 (28.6 %) were women. In participants with (vs. without) any increase in arterial inflammation over 6 months, the long-term changes in both MWT (% change MWT: 17.49 % vs. 1.74 %, p = 0.038) and MWA (% change MWA: 25.50 % vs. 3.59 %, p = 0.027) were significantly greater. Results remained significant after adjusting for clinical and biochemical covariates. Individuals with no increase in arterial inflammation over 6 months had no significant structural progression of atherosclerosis over 24 months as measured by MWT (p = 0.616) or MWA (p = 0.373). CONCLUSIONS: Short-term changes in arterial inflammation are associated with long-term structural atherosclerosis progression. These data support the concept that therapies that reduce arterial inflammation may attenuate or halt progression of atherosclerosis.


Assuntos
Arterite/complicações , Arterite/diagnóstico por imagem , Doenças das Artérias Carótidas/diagnóstico por imagem , Doenças das Artérias Carótidas/etiologia , Imagem por Ressonância Magnética/métodos , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos , Artérias Carótidas/diagnóstico por imagem , Progressão da Doença , Feminino , Fluordesoxiglucose F18 , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Prognóstico , Compostos Radiofarmacêuticos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
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