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1.
Med Sci Monit ; 27: e933915, 2021 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-34561413

RESUMO

BACKGROUND The aim of this study was to assess the effectiveness of bone conduction hearing aids in children under 2 years old who have congenital microtia and atresia. MATERIAL AND METHODS This prospective study involved 42 children under 2 years old with congenital microtia and atresia who were divided into 2 groups: 21 with unilateral defect and 21 with bilateral defect. All children were provided with bone conduction hearing aids on a softband. Air and bone auditory thresholds were assessed by auditory brainstem responses (ABRs). The LittlEARS questionnaire was used to evaluate auditory development at baseline and after 6 months of hearing aids use. Behavioral observation audiometry (BOA) was used to assess auditory thresholds and compare aided and unaided hearing. RESULTS After 6 months of hearing aid use, the total score of the LittlEARS questionnaire in children with unilateral defect was 24±5.60, while children with bilateral defect achieved a result of 26.29±6.17. Hearing thresholds in both groups with bone conduction hearing aids improved significantly and approached the normal level. CONCLUSIONS Our results confirm that bone conduction hearing aids provide an effective method of auditory rehabilitation for children with conductive and mixed hearing loss caused by microtia and atresia. Using bone conduction hearing aids in such children is crucial for proper hearing, speech, and language development.


Assuntos
Condução Óssea/fisiologia , Anormalidades Congênitas/terapia , Microtia Congênita/terapia , Orelha/anormalidades , Auxiliares de Audição , Audiometria/métodos , Anormalidades Congênitas/fisiopatologia , Microtia Congênita/fisiopatologia , Orelha/fisiopatologia , Feminino , Humanos , Lactente , Masculino , Estudos Prospectivos , Inquéritos e Questionários , Resultado do Tratamento
2.
J Laryngol Otol ; 135(9): 810-814, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34344488

RESUMO

OBJECTIVE: This study aimed to evaluate different auditory regions with audiological tests, based on the presumption that there may be damage to the structures in the hearing system after coronavirus disease 2019. METHODS: Twenty individuals with no history of coronavirus disease 2019 and 27 individuals diagnosed with coronavirus disease 2019 were compared. Pure tone, speech and extended high-frequency audiometry, acoustic immitansmetry, transient evoked and distortion product otoacoustic emissions testing, and auditory brainstem response testing were conducted. RESULTS: The pure tone audiometry and extended high-frequency mean threshold values were higher in the coronavirus disease 2019 group. The transient evoked otoacoustic emissions signal-to-noise ratios were bilaterally lower at 4 kHz in individuals with a coronavirus disease 2019 history. In the auditory brainstem response test, only the interpeak latencies of waves III-V were significantly different between groups. CONCLUSION: Coronavirus disease 2019 may cause damage to the hearing system. Patients should be followed up in the long term with advanced audiological evaluation methods in order to determine the extent and level of damage.


Assuntos
COVID-19/complicações , Transtornos da Audição/etiologia , Adulto , Audiometria , Audiometria de Resposta Evocada , Audiometria de Tons Puros , Limiar Auditivo , Estudos de Casos e Controles , Feminino , Transtornos da Audição/diagnóstico , Transtornos da Audição/virologia , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
3.
Med Clin North Am ; 105(5): 799-811, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34391534

RESUMO

A focused history, otoscopic and tuning fork examination and formal hearing testing are the diagnostic pillars for the workup of hearing loss and tinnitus. The causes of hearing loss and tinnitus are varied and range from relatively common age-related hearing loss to rare tumors of the brain and skull base. In this chapter, the authors explain the diagnostic workup of hearing loss and tinnitus, review the pathophysiology of the most common causes, and describe the treatments available.


Assuntos
Perda Auditiva/fisiopatologia , Zumbido/fisiopatologia , Audiometria , Implantes Cocleares , Auxiliares de Audição , Perda Auditiva/diagnóstico , Perda Auditiva/etiologia , Perda Auditiva/terapia , Perda Auditiva Condutiva/diagnóstico , Perda Auditiva Condutiva/fisiopatologia , Perda Auditiva Condutiva/terapia , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Neurossensorial/terapia , Testes Auditivos , Humanos , Atenção Primária à Saúde , Índice de Gravidade de Doença , Zumbido/diagnóstico , Zumbido/etiologia , Zumbido/terapia
4.
Biomed Res Int ; 2021: 6667531, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34409106

RESUMO

The results of recent animal studies have suggested that cochlear synaptopathy may be an important factor involved in presbycusis. Therefore, here, we aimed to examine whether cochlear synaptopathy frequently exists in patients with presbycusis and to describe the effect of cochlear synaptopathy on speech recognition in noise. Based on the medical history and an audiological examination, 94 elderly patients with bilateral, symmetrical, sensorineural hearing loss were diagnosed as presbycusis. An electrocochleogram, auditory brainstem responses, auditory cortical evoked potentials, and speech audiometry were recorded to access the function of the auditory pathway. First, 65 ears with hearing levels of 41-50 dB HL were grouped based on the summating potential/action potential (SP/AP) ratio, and the amplitudes of AP and SP were compared between the two resulting groups. Second, 188 ears were divided into two groups: the normal SP/AP and abnormal SP/AP groups. The speech recognition abilities in the two groups were compared. Finally, the relationship between abnormal electrocochleogram and poor speech recognition (signal-to-noise ratio loss ≥7 dB) was analyzed in 188 ears. The results of the present study showed: (1) a remarkable reduction in the action potential amplitude was observed in patients with abnormal SP/AP ratios; this suggests that cochlear synaptopathy was involved in presbycusis. (2) There was a large proportion of patients with poor speech recognition in the abnormal SP/AP group. Furthermore, a larger number of cases with abnormal SP/AP ratios were confirmed among patients with presbycusis and poor speech recognition. We concluded that cochlear synaptopathy is not uncommon among elderly individuals who have hearing ability deficits, and it may have a more pronounced effect on ears with declining auditory performance in noisy environments.


Assuntos
Audiometria/métodos , Cóclea/fisiopatologia , Presbiacusia/fisiopatologia , Idoso , Idoso de 80 Anos ou mais , Audiometria da Fala , Limiar Auditivo , Potenciais Evocados Auditivos do Tronco Encefálico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Percepção da Fala
5.
J Laryngol Otol ; 135(8): 684-690, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34342559

RESUMO

OBJECTIVE: The main purpose of the present study was to evaluate whether complications related to surgery for exostoses are associated with a decrease in patients' quality of life. METHODS: This was a retrospective study for which the following information was collected: sex, age, pre- and post-operative symptoms, pre- and post-operative audiological evaluation results, surgical approach, instruments used, complications, and Glasgow Benefit Inventory score. RESULTS: The study included 67 patients (94 ears). The three main complaints reported were wax retention, otitis externa and hearing loss. Surgical complications occurred in 14.9 per cent of patients. Patients experienced a significant benefit from surgery, especially in relation to somatic state, with a global Glasgow Benefit Inventory score of + 44.3. No significant difference was found between the global Glasgow Benefit Inventory changes and surgery-related complications (p = 0.093). CONCLUSION: After surgery for exostoses, the vast majority of patients showed improvement. Complications related to surgery in general do not seem to influence patients' satisfaction with surgery.


Assuntos
Meato Acústico Externo/cirurgia , Exostose/cirurgia , Procedimentos Cirúrgicos Otológicos , Adulto , Idoso , Audiometria , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Otológicos/efeitos adversos , Procedimentos Cirúrgicos Otológicos/métodos , Procedimentos Cirúrgicos Otológicos/psicologia , Satisfação do Paciente , Qualidade de Vida , Estudos Retrospectivos , Adulto Jovem
6.
J Laryngol Otol ; 135(9): 795-798, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34266511

RESUMO

OBJECTIVE: To statistically analyse the hearing thresholds of two cohorts undergoing stapedotomy for otosclerosis with two different prostheses. METHOD: A retrospective study was conducted comparing NiTiBOND (n = 53) and Nitinol (n = 38) prostheses. RESULTS: Average follow-up duration was 4.1 years for NiTiBOND and 4.4 years for Nitinol prostheses. The post-operative air-bone gap was 10 dB or less, indicating clinical success. The p-values for differences between (1) pre- and post-operative values in the NiTiBOND group, (2) pre- and post-operative values in the Nitinol group, (3) pre-operative values and (4) post-operative values in the two groups were: air-bone gap - p < 0.001, p < 0.001, p = 0.631 and p = 0.647; four-frequency bone conduction threshold - p = 0.076, p = 0.129, p < 0.001 and p = 0.005; four-frequency air conduction threshold - p < 0.001, p < 0.001, p = 0.043 and p = 0.041; three-frequency (1, 2 and 4 kHz) bone conduction threshold pre-operatively - p = 0.639, p = 0.495, p = 0.001 and p = 0.01; and air conduction threshold at 4 kHz: - p < 0.001, p < 0.001, p = 0.03 and p = 0.058. CONCLUSION: Post-operative audiological outcomes for NiTiBOND and Nitinol were comparable.


Assuntos
Audiometria/estatística & dados numéricos , Audição , Prótese Ossicular , Otosclerose/fisiopatologia , Cirurgia do Estribo/instrumentação , Adulto , Idoso , Ligas , Limiar Auditivo , Condução Óssea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Otosclerose/cirurgia , Período Pós-Operatório , Desenho de Prótese , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
7.
Codas ; 33(4): e20190266, 2021.
Artigo em Português, Inglês | MEDLINE | ID: mdl-34259779

RESUMO

PURPOSE: To describe the performance of elderly individuals in Pitch Pattern Sequence (PPS) and Duration Pattern Sequence (DPS) tests and research related factors. METHODS: An observational, cross-sectional study conducted with elderly people aged 60 to 79 years. The participants underwent cognitive screening tests, interviews containing socio-demographic data and general health, as well as audiologic evaluation and temporal auditory processing (PPS and DPS) evaluation tests. A descriptive analysis of the association between the performance in temporal processing and the variables gender, age, level of education and audiometric alterations was conducted through multiple linear regression. RESULTS: 86 elderly people participated in the study, most of them female, with ages between 60 and 69. Male participants performed better in both tests as well as the participants with higher education, whereas no difference in performance was observed across the different age ranges. In the DPS, the participants with auditory alteration performed worse in relation to the ones with average frequencies of 0.5 to 4 kHz. CONCLUSION: The male gender and higher level of education were associated with better results in the temporal ordering tests, whereas auditory alteration was associated with worse performance only in the pitch pattern sequence test.


Assuntos
Testes Auditivos , Percepção do Tempo , Idoso , Audiometria , Percepção Auditiva , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
8.
J Int Adv Otol ; 17(4): 348-352, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34309557

RESUMO

OBJECTIVES: Fibromyalgia syndrome is a disorder of widespread pain with unknown etiology. These patients frequently suffer from otologic complaints. This study aims to analyze the audiovestibular functions in patients with fibromyalgia syndrome. METHODS: The study included 33 fibromyalgia patients and 33 healthy volunteers. All the study subjects underwent audiological assessment, multifrequency tympanometry, transient otoacoustic emission, and ocular and cervical vestibular-evoked myogenic potentials tests. RESULTS: Pure-tone hearing thresholds of right and left ears were found to be decreased in fibromyalgia patients compared to controls (P < 0.05). Middle ear resonance frequency values were significantly decreased in patients with fibromyalgia syndrome compared to controls (P < .05). The values for signal-to-noise ratios were higher in controls than in the FMS patients. The difference was significant for 1000, 2000, and 4000 Hz (P > .005). Cervical vestibular-evoked myogenic potential waves were obtained in all controls, but could not be obtained in 5 right ears and 4 left ears of the fibromyalgia patients (P < .05). Also, ocular vestibular-evoked myogenic potentials were obtained in all controls, but could not be obtained in 7 right ears and 10 left ears of the patients with fibromyalgia syndrome (P < .05). CONCLUSION: Our findings support the presence of audiovestibular dysfunction in patients with fibromyalgia. Further research that focuses on the pathogenesis of these dysfunctions is required.


Assuntos
Fibromialgia , Potenciais Evocados Miogênicos Vestibulares , Testes de Impedância Acústica , Audiometria , Fibromialgia/complicações , Humanos , Emissões Otoacústicas Espontâneas
9.
Otol Neurotol ; 42(9): e1250-e1255, 2021 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-34282098

RESUMO

OBJECTIVE: Concurrent bilateral congenital aural atresia (CAA) and profound sensorineural hearing loss are rare. While not a contraindication, temporal bone and cochleovestibular abnormalities are an important consideration for cochlear implantation (CI) candidacy. Intraoperative image-guided surgical navigation may play a role during CI surgery in patients with complex anatomy, such as CAA. PATIENT: One patient with bilateral CAA, cochlear dysplasia, speech delay, and profound sensorineural hearing loss underwent candidacy evaluation for cochlear implantation. INTERVENTIONS: Cochlear implantation using intraoperative image-guided navigation. MAIN OUTCOME MEASURES: (1) Registration accuracy, (2) surgical outcomes, (3) audiometry. RESULTS: A four-year-old girl with complete bilateral CAA and profound sensorineural hearing loss successfully underwent a right transmastoid approach for CI using intraoperative image-guided navigation with sticker fiducials. Bony landmarks included the mastoid tip, tympanomastoid suture line, helical root, zygomatic root, and lateral brow. A registration accuracy of 0.9 mm was achieved. There were no intraoperative or immediate postoperative complications. Postoperatively, Neural Response Imaging was confirmed on 9 electrodes and behavioral testing demonstrated Ling-6 access at 30 dB. On most recent follow-up, she has demonstrated gains in language development, vocalizations, and uses total communication in a hearing-impaired educational environment. CONCLUSIONS: Children with CAA and profound sensorineural hearing loss may be candidates for cochlear implantation, with successful outcomes in the setting of complex anatomy. Surgical navigation may play a role corroborating intraoperative landmarks.


Assuntos
Implante Coclear , Implantes Cocleares , Perda Auditiva Neurossensorial , Perda Auditiva , Percepção da Fala , Audiometria , Criança , Pré-Escolar , Cóclea/cirurgia , Feminino , Perda Auditiva/cirurgia , Perda Auditiva Neurossensorial/cirurgia , Humanos , Resultado do Tratamento
10.
J Coll Physicians Surg Pak ; 31(8): 969-974, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34320717

RESUMO

OBJECTIVE: To analyse postoperative audiological findings in fenestral otosclerosis patients treated with stapedotomy, focal location-extensiveness findings on temporal high-resolution computed tomography (HRCT), and intraoperative macroscopic stapes footplate findings. Moreover, preoperative audiological findings were compared with HRCT and intraoperative macroscopic findings. STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: Department of Otorhinolaryngology, University of Health Sciences, Ankara Numune Training and Research Hospital, Turkey from January 2015 to January 2018. METHODOLOGY: Patients were classified according to the temporal bone HRCT findings into three groups based on otosclerotic focus location and extensiveness. Macroscopic classification was based on the intraoperative findings of blue and white footplate. Patients with obliterative otosclerosis were not included in the study. Preoperative and postoperative audiological findings as well as surgical success were investigated. Findings were compared with HRCT and macroscopic classification groups. RESULTS: Postoperative air bone gap (ABG) increased as HRCT class increased from 0 to 3, meaning a more extensive otosclerotic focus (p=0.002). The comparison of the audiological outcomes, in accordance with the intraoperative findings, revealed that the postoperative air conduction pure-tone averages (AC PTA), ABG and ABG difference were higher in the white footplate group, with statistically significant differences compared to blue footplate group (p = 0.039, p = 0.001 and p=0.029, respectively). CONCLUSION: Postoperative audiological findings were found to be correlated with intraoperative and HRCT findings. A white footplate seen at surgery or a more extensive otosclerotic focus on temporal HRCT indicates a suboptimal audiological outcome. HRCT findings should be taken into account when planning the surgery. Key Words: Otosclerosis, Temporal bone HRCT, Footplate color, Stapedotomy, Audiometry.


Assuntos
Otosclerose , Cirurgia do Estribo , Audiometria , Humanos , Otosclerose/diagnóstico por imagem , Otosclerose/cirurgia , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Turquia/epidemiologia
11.
Artigo em Chinês | MEDLINE | ID: mdl-34304485

RESUMO

Objective:To investigate the key factors related to the severity of chronic subjective tinnitus through a complex network analysis. Methods:A retrospective study about patients with chronic subjective tinnitus presented to Peking Union Medical College Hospital from December 2019 to October 2020 was conducted. The demographic information, audiometric and tinnitus-related tests, and scores of Tinnitus Handicap Inventory(THI), Hospital Anxiety and Depression Scale(HADS), Pittsburgh Sleep Quality Index(PSQI) and Visual Analogue Scale(VAS) of tinnitus loudness and annoyance were set as nodes in a complex network which was conducted and analyzed through the R package. Results:A total of 183 patients were enrolled, including 99(54.1%) males and 84(45.9%) females, with an average age of(41.65±1.05) years. The results of the complex network analysis showed that anxiety and sleep disorder were closely related to THI score, and anxiety was more important than sleep disorder. There was a strong correlation between self-reported anxiety and insomnia. Demographic characteristics, audiologic and tinnitus-associated tests were not significantly related to THI score. Conclusion:Anxiety and sleep disturbance were key factors related to tinnitus severity, and anxiety played a more important role. There was an obvious correlation between sleep disorder and anxiety, and they might have a superimposed effect on tinnitus severity. Future therapies of tinnitus should pay more attention on releasing anxiety and insomnia.


Assuntos
Distúrbios do Início e da Manutenção do Sono , Zumbido , Adulto , Ansiedade/epidemiologia , Audiometria , Feminino , Humanos , Masculino , Estudos Retrospectivos , Inquéritos e Questionários
12.
Afr J Prim Health Care Fam Med ; 13(1): e1-e7, 2021 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-34212742

RESUMO

BACKGROUND: Childhood hearing loss is a global epidemic most prevalent in low- and middle-income countries where hearing healthcare services are often inaccessible. Referrals for primary care services to central hospitals add to growing lists and delays the time-sensitive treatment of childhood hearing loss. AIM: To compare a centralised tertiary model of hearing healthcare with a decentralised model through district hearing screening for children in the Western Cape province, South Africa. SETTING: A central paediatric tertiary hospital in Cape Town and a district hospital in the South Peninsula region. METHODS: A pragmatic quasi-experimental study design was used with a 7-month control period at a tertiary hospital (June 2019 to December 2019). Decentralising was measured by attendance rates, travelling distance, number of referrals to the tertiary hospital and hearing outcomes. There were 315 children in the tertiary group and 158 in the district group. Data were collected from patient records and an electronic database at the tertiary hospital. RESULTS: Attendance rate at the district hospital was significantly higher (p 0.001). Travel distance to the district hospital was significantly shorter (p 0.001). Number of referrals to the tertiary hospital decreased significantly during the intervention period (p 0.001). Most children in both the tertiary and district groups (78.7% and 80.4%, respectively) passed initial hearing screening bilaterally. CONCLUSION: Hearing screening should be conducted at the appropriate level of care to increase access, reduce patient travelling distances and associated costs and reduce the burden on tertiary-level hospitals.


Assuntos
Audiometria/métodos , Atenção à Saúde/organização & administração , Acesso aos Serviços de Saúde/estatística & dados numéricos , Transtornos da Audição/diagnóstico , Perda Auditiva/diagnóstico , Testes Auditivos/métodos , Programas de Rastreamento/organização & administração , Pediatria , Audiologia/métodos , Pré-Escolar , Atenção à Saúde/métodos , Feminino , Audição , Humanos , Masculino , Emissões Otoacústicas Espontâneas , África do Sul/epidemiologia
13.
Vestn Otorinolaringol ; 86(3): 41-45, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34269022

RESUMO

The features of impedance audiometry with a 226 Hz probe frequency in newborns and children in the first months of life after acute otitis media were analyzed. The age dynamics of tympanograms in children in the first year of life is determined.


Assuntos
Otite Média com Derrame , Otite Média , Testes de Impedância Acústica , Audiometria , Criança , Humanos , Recém-Nascido , Microcirurgia , Otite Média/diagnóstico
14.
Laryngoscope ; 131 Suppl 6: S1-S25, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34142720

RESUMO

OBJECTIVES/HYPOTHESIS: To document the history of hearing seeing in children and adults. STUDY DESIGN: A literature search in all languages was carried out with the terms of hearing screening from the following sources: Pub Med, Science Direct, World Catalog, Index Medicus, Google scholar, Google Books, National Library of Medicine, Welcome historical library and The Library of Congress. METHODS: The primary sources consisting of books, scientific reports, public documents, governmental reports, and other written material were analyzed to document the history of hearing screening. RESULTS: The concept of screening for medical conditions that, when found, could influence some form of the outcome of the malady came about during the end of 19th century. The first applications of screening were to circumscribe populations, schoolchildren, military personnel, and railroad employees. During the first half of the 20th century, screening programs were extended to similar populations and were able to be expanded on the basis of the improved technology of hearing testing. The concept of universal screening was first applied to the inborn errors of metabolism of newborn infants and particularly the assessment of phenylketonuria in 1963 by Guthrie and Susi. A limited use of this technique has been the detection of genes resulting in hearing loss. The use of a form of hearing testing either observational or physiological as a screen for all newborns was first articulated by Larry Fisch in 1957 and by the end of the 20th century newborn infant screening for hearing loss became the standard almost every nation worldwide. CONCLUSIONS: Hearing screening for newborn infants is utilized worldwide, schoolchildren less so and for adults many industrial workers and military service undergo hearing screening, but this is not a general practice for screening the elderly. LEVEL OF EVIDENCE: NA Laryngoscope, 131:S1-S25, 2021.


Assuntos
Testes Auditivos/história , Triagem Neonatal/história , Adulto , Fatores Etários , Audiometria/história , Audiometria/instrumentação , Criança , Cristianismo/história , Perda Auditiva/diagnóstico , Perda Auditiva/história , História do Século XIX , História do Século XX , História do Século XXI , História Antiga , Humanos , Lactente , Recém-Nascido , Judaísmo/história , Erros Inatos do Metabolismo/diagnóstico , Erros Inatos do Metabolismo/história , Fenilcetonúrias/diagnóstico , Fenilcetonúrias/história
15.
Medicine (Baltimore) ; 100(25): e24691, 2021 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-34160378

RESUMO

ABSTRACT: Branchio-Oto (BO) syndrome is one of the common syndromic forms of hearing loss. In this study, we aimed to characterize the clinical and genetic features of BO syndrome in a Chinese deaf family.The proposita in this study was a 29-years-old Chinese female with hearing loss, microtia, anterior concave auricle, and right branchial fistula. The family members agreed to undergo clinical examination. We collected blood samples from 7 family members, including 4 affected by the syndrome. Genomic DNA was extracted and subjected to Sanger sequencing. In addition, bioinformatics software SWISS MODEL was used to predict the protein encoded by EYA transcriptional coactivator and phosphatase 1 (EYA1) gene.Intra-familial consistency can be observed in the clinical phenotypes of BO syndrome in this family. EYA1 c.1627C>T (p.Gln543Ter) mutation was identified as the pathogenic cause in this family.This study reports a mutation associated with BO syndrome in a Chinese Han family. We highlight the utility of genetic testing in the diagnosis of BO syndrome. Thus, we believe that this report would provide a basis for the diagnosis of similar diseases in the future.


Assuntos
Síndrome Brânquio-Otorrenal/genética , Microtia Congênita/genética , Perda Auditiva/genética , Peptídeos e Proteínas de Sinalização Intracelular/genética , Proteínas Nucleares/genética , Proteínas Tirosina Fosfatases/genética , Adulto , Idoso , Grupo com Ancestrais do Continente Asiático/genética , Audiometria , Síndrome Brânquio-Otorrenal/diagnóstico , Criança , Biologia Computacional , Microtia Congênita/diagnóstico , Análise Mutacional de DNA , Feminino , Testes Genéticos , Perda Auditiva/congênito , Perda Auditiva/diagnóstico , Humanos , Cariotipagem , Masculino , Pessoa de Meia-Idade , Linhagem
16.
Int Arch Occup Environ Health ; 94(6): 1191-1199, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34023963

RESUMO

OBJECTIVES: To evaluate whether there is an increased risk for noise-induced hearing loss at high altitude rsp. in hypobaric hypoxia. METHODS: Thirteen volunteers got standard audiometry at 125, 250, 500, 750, 1000, 1500, 2000, 3000, 4000, 6000, and 8000 Hz before and after 10 min of white noise at 90 dB. The system was calibrated for the respective altitude. Measurements were performed at Kathmandu (1400 m) and at Gorak Shep (5300 m) (Solo Khumbu/Nepal) after 10 days of acclimatization while on trek. Temporary threshold shift (TTS) was analyzed by descriptive statistics and by factor analysis. RESULTS: TTS is significantly more pronounced at high altitudes. Acclimatization does not provide any protection of the inner ear, although it increases arterial oxygen saturation. CONCLUSION: The thresholds beyond which noise protection is recommended (> 80 dB) or necessary (> 85 dB) are not sufficient at high altitudes. We suggest providing protective devices above an altitude of 1500 m ("ear threshold altitude") when noise level is higher than 75 dB and using them definitively above 80 dB. This takes the individual reaction on hypobaric hypoxia at high altitude into account.


Assuntos
Altitude , Limiar Auditivo , Exposição Ambiental/efeitos adversos , Ruído/efeitos adversos , Oxigênio , Aclimatação , Adulto , Audiometria , Expedições , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
17.
Clin Neurophysiol ; 132(7): 1694-1707, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34038848

RESUMO

OBJECTIVE: To investigate oscillatory brain activity changes following acoustic stimulation in tinnitus and whether these changes are associated with behavioral measures of tinnitus loudness. Moreover, differences in ongoing brain activity between individuals with and without residual inhibition (RI) are examined (responders vs. non-responders). METHODS: Three different types of noise stimuli were administered for acoustic stimulation in 45 tinnitus patients. Subjects resting state brain activity was recorded before and after stimulation via EEG alongside with subjective measurements of tinnitus loudness. RESULTS: Delta, theta and gamma band power increased, whereas alpha and beta power decreased from pre to post stimulation. Acoustic stimulation responders exhibited reduced gamma and a trend for enhanced alpha activity with the latter localized in the right inferior temporal gyrus. Post stimulation, individuals experiencing RI showed higher theta, alpha and beta power with a peak power difference in the alpha band localized in the right superior temporal gyrus. Neither correlations with behavioral tinnitus measures nor stimulus-specific changes in EEG activity were present. CONCLUSIONS: Our observations might be indicative of trait-specific forms of oscillatory signatures in different subsets of the tinnitus population related to acoustic tinnitus suppression. SIGNIFICANCE: Results and insights are not only useful to understand basic neural mechanisms behind RI but are also valuable for general neural models of tinnitus.


Assuntos
Estimulação Acústica/métodos , Eletroencefalografia/métodos , Inibição Neural/fisiologia , Zumbido/diagnóstico , Zumbido/fisiopatologia , Adulto , Idoso , Audiometria/métodos , Ondas Encefálicas/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
18.
BMJ Case Rep ; 14(5)2021 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-34045191

RESUMO

A 45-year-old man presented with a history of sudden sensory neural hearing loss and severe tinnitus in his left ear. Audiological investigations revealed a profound hearing loss on his left ear and mild conductive hearing loss on his right. Tinnitus pitch and loudness were matched to a 4 kHz narrow-band noise at 50dBHL and subjective tinnitus questionnaires revealed that he had a catastrophic handicap (grade IV). Traditional audiological treatment approaches (tinnitus maskers, hearing aid and sound therapy) that stimulate the cochlea to induce cortical reorganisation were futile. Hence, a top-down approach (transcranial direct current stimulation (tDCS)) to directly modulate the cortical centres was attempted. tDCS was provided for a sum of 15 sessions across 2 phases. There was a substantial improvement in the tinnitus loudness, distress and depression scores which maintained for 3 months post-treatment. tDCS is a potential treatment for phantom perceptions (tinnitus) in cases of profound sensory neural hearing loss where there is no residual sensory ability. Tailor-made approaches seem to be more appropriate until a standard protocol for tDCS in tinnitus is established.


Assuntos
Auxiliares de Audição , Zumbido , Estimulação Transcraniana por Corrente Contínua , Audiometria , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Zumbido/terapia
19.
Ear Hear ; 42(4): 870-885, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33974792

RESUMO

OBJECTIVES: Military Service members and Veterans commonly report hearing loss and tinnitus, both of which can result in significant disability. During military service, Service members are exposed to many different types of loud noise, which is strongly associated with hearing loss and tinnitus. Other military-related exposures, such as chemicals and traumatic brain injury (TBI), are also linked with auditory problems. The purpose of the "Noise Outcomes in Servicemembers Epidemiology" (NOISE) study is to gather information from Active-Duty Service members and recently separated Veterans about their military and nonmilitary noise exposures, other relevant military and nonmilitary exposures, and potential outcomes of these exposures including tinnitus, hearing loss, and other hearing-related health concerns. DESIGN: The NOISE study assesses lifetime noise exposures, chemical and blast exposures, TBI, physical and psychiatric comorbidities, and other military and nonmilitary exposures and outcomes that can affect auditory function. Participants undergo comprehensive in-person audiologic examinations; those who experience tinnitus undergo a complete tinnitus assessment. Exposures and select outcomes are reassessed annually by mail, and the comprehensive in-person assessment is completed every 5 years. This report presents descriptive, baseline data obtained from the first 690 participants enrolled between 2014 and 2018. RESULTS: Some notable findings from this analysis include: (1) the prevalence of hearing loss in the sample was 8% for low frequencies (0.25 to 2 kHz), 20% for high frequencies (3 to 8 kHz), and 39% for extended high frequencies (9 to 16 kHz); (2) the prevalence of tinnitus was 53%; (3) the prevalence of both hearing loss and tinnitus was higher among those with higher age, more years of military service, greater degree of noise exposure, and exposures to blasts and/or TBI in the military; and (4) tinnitus was most prevalent among participants who serve/served in the Army relative to the other military branches. CONCLUSIONS: The NOISE study is acquiring comprehensive data on military-related auditory dysfunction. It is the first of its kind to enroll active Service members and recently separated Veterans into a longitudinal study to examine the etiology and outcomes of tinnitus and hearing loss in this population. Although these data do not necessarily represent the entire military and Veteran populations, ongoing enrollment is focused on increasing generalizability and will also provide the statistical power to conduct multivariable analyses. This will allow us to examine longitudinal associations of interest while controlling for potential confounders and other possible sources of error. These data will provide critical knowledge to refine future military hearing conservation efforts and inform efforts to develop future treatments.


Assuntos
Perda Auditiva Provocada por Ruído , Zumbido , Audiometria , Audição , Perda Auditiva Provocada por Ruído/epidemiologia , Humanos , Estudos Longitudinais , Ruído , Zumbido/epidemiologia
20.
Int J Pediatr Otorhinolaryngol ; 144: 110686, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33838463

RESUMO

OBJECTIVES: Extended high frequency (EHF) audiometry is the recommended method for monitoring oxotoxic hearing loss in children. This study aims to provide high quality reference audiological data for the EHF range in healthy children. METHODS: Participants were 126 healthy schoolchildren between 6 and 14 years of age. All participants were term born with normal birthweight, had not suffered severe neonatal illness and had no history of middle ear disease. RESULTS: The averaged mean (SD) hearing threshold for the EHF 9, 10, 11.2, 12.5, 14 and 16 kHz was -0.4 (6.0) dB HL. The lowest mean hearing thresholds were observed at 14 kHz with -4.2 (8.7) dB and at 16 kHz with -6.4 (12.1) dB HL. We found significantly lower thresholds at 16 kHz for children aged 6-9 years (-8.7 dB HL) compared to age 10-14 years (-3.9 db HL), p 0.042. For both age groups the inter-subject variability increased in the highest frequencies. We found no significant differences in mean hearing thresholds between right and left ears at any frequency, and no gender differences in the EHF range. CONCLUSION: Our findings support that decreased hearing sensitivity in the EHF's may start around or even before the age of 10 years. In order to use EHF audiometry for ototoxic monitoring in children, we suggest to establish an international reference standard for hearing levels in children under the age of 18. Specific references for different age groups are needed as hearing in the EHF range appears to gradually deteriorate from an early age. CLINICAL TRIAL REGISTRATION: NCT03253614.


Assuntos
Perda Auditiva , Audição , Adolescente , Audiometria , Audiometria de Tons Puros , Limiar Auditivo , Criança , Humanos , Recém-Nascido , Instituições Acadêmicas
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