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1.
An. psicol ; 37(2): 341-351, mayo-sept. 2021. tab, graf, mapas
Artigo em Espanhol | IBECS | ID: ibc-202557

RESUMO

El presente estudio bibliométrico tuvo como objetivo conocer y analizar la actividad científica disponible sobre percepción y detección de violencia de género (VG) e identificación como víctimas. Se realizó una búsqueda sin límite temporal en la base de datos Scopus hallando 2.152 documentos. Para reducir el ruido documental de la búsqueda, se cribaron los resultados y se analizaron 974 documentos finales procedentes de 465 fuentes documentales, 160 revistas, 2.758 autores/as, 159 instituciones y 79 países. Los resultados muestran un aumento en la producción en los últimos años, destacando la publicación de artículos originales. Asimismo, predomina la autoría única por país, siendo Estados Unidos el país puntero. Entre los objetivos de los documentos más citados se encuentra la detección de VG por el personal sanitario, la valoración del riesgo de reincidencia mediante la percepción de las víctimas, así como el estudio de percepciones y actitudes de diferentes actores hacia la VG


This bibliometric study seeks to know and analyse the available scientific activity on the perception and detection of gender violence as well as in the identification as victims. An unlimited search was conducted in the Scopus database, finding 2,152 documents. Subsequently, the results were screened by reducing the documentary noise. The results were obtained from 1984-2020 and the final 974 documents were analysed from 465 documentary sources, 160 journals, 2,758 authors, 159 institutions, and 79 countries. The results show an increase in production in recent years, highlighting the publication of original articles. Likewise, the single author-ship per country predominates, being the United States the leading country. The main objectives of the most cited documents are detection of gender violence by healthcare personnel, assessment of the risk of recidivism through the perception of the victims, as well as the study of perceptions and attitudes of different actors towards gender-violence


Assuntos
Humanos , Violência de Gênero/estatística & dados numéricos , Vítimas de Crime/estatística & dados numéricos , Bibliometria , Publicações Periódicas como Assunto/estatística & dados numéricos , Fatores de Tempo , Autoria e Coautoria na Publicação Científica , Bases de Dados Bibliográficas
2.
F1000Res ; 10: 401, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34408850

RESUMO

Background: The reliable and usable (semi)automation of data extraction can support the field of systematic review by reducing the workload required to gather information about the conduct and results of the included studies. This living systematic review examines published approaches for data extraction from reports of clinical studies. Methods: We systematically and continually search MEDLINE, Institute of Electrical and Electronics Engineers (IEEE), arXiv, and the dblp computer science bibliography databases. Full text screening and data extraction are conducted within an open-source living systematic review application created for the purpose of this review. This iteration of the living review includes publications up to a cut-off date of 22 April 2020. Results: In total, 53 publications are included in this version of our review. Of these, 41 (77%) of the publications addressed extraction of data from abstracts, while 14 (26%) used full texts. A total of 48 (90%) publications developed and evaluated classifiers that used randomised controlled trials as the main target texts. Over 30 entities were extracted, with PICOs (population, intervention, comparator, outcome) being the most frequently extracted. A description of their datasets was provided by 49 publications (94%), but only seven (13%) made the data publicly available. Code was made available by 10 (19%) publications, and five (9%) implemented publicly available tools. Conclusions: This living systematic review presents an overview of (semi)automated data-extraction literature of interest to different types of systematic review. We identified a broad evidence base of publications describing data extraction for interventional reviews and a small number of publications extracting epidemiological or diagnostic accuracy data. The lack of publicly available gold-standard data for evaluation, and lack of application thereof, makes it difficult to draw conclusions on which is the best-performing system for each data extraction target. With this living review we aim to review the literature continually.


Assuntos
Publicações , Relatório de Pesquisa , Automação , Bases de Dados Bibliográficas , MEDLINE
3.
BMJ Open ; 11(8): e048031, 2021 08 24.
Artigo em Inglês | MEDLINE | ID: mdl-34429311

RESUMO

INTRODUCTION: Complex organisational arrangements are required to deliver antenatal and newborn screening programmes. Decision-makers consider the benefits and harms of screening when reviewing the evidence about these programmes. Economic evaluations contribute one important part of this assessment process. However, it is not fully understood what approaches health economic assessments have adopted to measure and value benefits and harms. This study aims to systematically review and critique the published and grey literature on methods for identifying, measuring and valuing the benefits and harms of antenatal and newborn screening adopted by health economic assessments. METHODS AND ANALYSIS: Nine bibliographic databases will be searched from 2000 onwards. These search strategies will be supplemented by manual reference searching of bibliographies, forward citation searching, contacts with experts, author searching and web searching for grey literature. Studies will be selected for review if they report health economic assessments of an antenatal or newborn screening programme. Assessments of title and abstracts and full reports will be undertaken independently with disagreements resolved through discussion. Data extraction will include fields to assess the reporting quality of the studies using the Consolidated Health Economic Evaluation Reporting Standards statement and a bespoke ancillary form to assess how benefits and harms have been accounted for. ETHICS AND DISSEMINATION: This is an evidence synthesis review from already published materials and hence ethics committee approval or written informed consent will not be required. Our results will be disseminated by publishing in high-impact peer-review journals and presenting at relevant conferences. PROSPERO REGISTRATION NUMBER: CRD42020165236.


Assuntos
Economia Médica , Triagem Neonatal , Análise Custo-Benefício , Bases de Dados Bibliográficas , Feminino , Literatura Cinzenta , Humanos , Recém-Nascido , Gravidez , Revisões Sistemáticas como Assunto
4.
BMJ Open ; 11(6): e041036, 2021 06 03.
Artigo em Inglês | MEDLINE | ID: mdl-34083325

RESUMO

INTRODUCTION: Chronic pain is a distressing condition and often poorly treated and managed. Psychological therapies are considered first-line intervention for people with chronic pain. Common psychological therapies require extensive clinician training and specialist qualifications. One approach that does not need lengthy training nor specialist qualification, but has empirical support in other health domains, is behavioural activation (BA). BA seeks to increase engagement in behaviours that are valued by the person and progress through behaviours that can increase mood and develop skills that build satisfying routines. BA can help people to manage their condition through scheduling behaviours, promoting routine and mastery over their condition. The extent to which BA has been used to support people living with chronic pain is not clear. METHODS AND ANALYSIS: This scoping review aims to identify published studies describing the application of BA to support people living with chronic pain. To map the evidence regarding BA and chronic pain, including the study type and the associated evidence, a scoping review was adopted. The search will be conducted in bibliographic databases, clinical trial registries and grey literature. No date limits will be applied to the search strategy. Screening of titles and abstracts, and full-text screening, will be independently undertaken by two investigators using Covidence software. Any disagreement between investigators will be resolved by a third investigator. Data from included publications will be extracted using a customised data extraction tool. ETHICS AND DISSEMINATION: The scoping review is an analysis of existing data and therefore ethics approval is not required. The findings of this scoping review will further our understanding of how BA has been used to support people living with chronic pain and inform future training and education programmes in this area.


Assuntos
Dor , Projetos de Pesquisa , Bases de Dados Bibliográficas , Escolaridade , Humanos , Revisões Sistemáticas como Assunto
5.
Rev. ADM ; 78(3): 162-166, mayo-jun. 2021.
Artigo em Espanhol | LILACS | ID: biblio-1254811

RESUMO

La enfermedad COVID-19 fue declarada pandemia por la Organización Mundial de la Salud el 11 de marzo de 2020. El síndrome respiratorio agudo severo coronavirus-2 (SARS-CoV-2) es un virus transmitido de animales a seres humanos, altamente contagioso, cuyo periodo de incubación es de uno a 14 días. Los momentos por los que atraviesan la mayoría de los países debido a la pandemia declarada del COVID-19 han llevado a la proclamación de órdenes gubernamentales y/o recomendaciones en relación a la atención dental que debe dispensarse. En el momento actual, no se dispone de protocolos específicos oficiales, ni nacionales ni internacionales, que aborden de manera clara cómo debe proceder el odontólogo en su práctica diaria en la etapa posterior al confinamiento para trabajar con las mejores garantías de protección para los pacientes y el equipo humano de la consulta odontológica. Este estudio tuvo como objetivo analizar consideraciones para la atención de tratamientos endodóncicos en el contexto de la pandemia de COVID-19. Para lograr este objetivo se realizó una revisión bibliográfica en diferentes bases de datos, como: Google Scholar, Springer Link, Scopus, PubMed, para ello se emplearon estrategias de búsqueda, utilizando descriptores como: «endodontic¼, «recomendations¼, «odontology¼, «COVID-19¼, «pandemic¼ y operadores booleanos, con la finalidad de obtener información relevante y precisa. Contribuyendo a la práctica de la endodoncia con un protocolo general para el manejo de emergencias que muestre el fundamento del diagnóstico, los procedimientos clínicos y el uso de equipos de protección personal y barreras en el consultorio odontológico durante el brote de COVID-19 (AU)


The COVID-19 disease was declared a pandemic by the World Health Organization on March 11, 2020. The severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a virus transmitted from animals to humans, highly contagious, whose incubation period is one to 14 days. The times that most countries are going through due to the declared COVID-19 pandemic have led to the proclamation of government orders and/or recommendations regarding the dental care that should be provided. At the present time, there are no specific official national or international protocols that clearly address how the dentist should proceed, in their daily practice, in the post-confinement stage, to work with the best guarantees of protection for the patients and the human team of the dental practice. The objective of this study was to analyze considerations for the care of endodontic treatments in the context of the COVID-19 pandemic. To achieve this objective, a bibliographic review was carried out in different databases, such as: Google Scholar, Springer Link, Scopus, PubMed, for this, search strategies were used, using descriptors such as: «endodontic¼, «recommendations¼, «odontology¼, «COVID-19¼, «pandemic¼ and Boolean operators, in order to obtain relevant and accurate information. Contributing to the practice of endodontics a general protocol for emergency management that shows the rationale for diagnosis, clinical procedures and the use of personal protective equipment and barriers in the dental office during the COVID-19 outbreak (AU)


Assuntos
Humanos , Tratamento do Canal Radicular/normas , COVID-19 , Esterilização , Controle de Doenças Transmissíveis , Protocolos Clínicos , Desinfecção , Bases de Dados Bibliográficas , Controle de Infecções Dentárias/métodos , Consultórios Odontológicos/normas
6.
Rev. cuba. cir ; 60(2): e1010, tab
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1280221

RESUMO

La rehabilitación multimodal constituye un conjunto de medidas perioperatorias que sustituye prácticas tradicionales. Su implementación está fundada en criterios de medicina basada en la evidencia. El objetivo del artículo es implementar el protocolo ERAS (Enhanced Recovery After Surgery) por sus siglas en inglés, en la cirugía esofágica electiva por cáncer. Se tuvo en cuenta como documento base el protocolo ERAS del servicio. Se apoyó en la sistemática revisión de la evidencia. Se amplió la búsqueda bibliográfica en las bases de datos Biblioteca Cochrane Plus (Cochrane Library) y Medline desde el 2000 hasta 2018. Las medidas a aplicar se dividen en 3 bloques: preoperatorio, perioperatorio y postoperatorio. Su conjunto da lugar al documento de consenso que integra todas las medidas. La aplicación de protocolos de rehabilitación multimodal en cirugía esofágica reducirá la morbimortalidad postoperatoria, la estancia y los costes hospitalarios(AU)


Multimodal rehabilitation involves a set of perioperative measures that substitutes traditional practices. Its implementation is founded upon evidence-based medicine criteria. The objective of the article is to implement of the ERAS (Enhanced Recovery After Surgery) protocol for elective esophageal cancer surgery. The ERAS protocol of the service was taken into account as a base document. It was supported by systematic evidence review. The bibliographic search was broadened in the Cochrane Library and the Medline databases, from 2000 to 2018. The measures to be applied are divided into three blocks: preoperative, perioperative and postoperative. This set gives rise to the consensus document that integrates all the measures. The application of multimodal rehabilitation protocols in esophageal surgery will reduce postoperative morbidity and mortality, hospital stay and costs(AU)


Assuntos
Humanos , Neoplasias Esofágicas/cirurgia , Indicadores de Morbimortalidade , Medicina Baseada em Evidências/métodos , Recuperação Pós-Cirúrgica Melhorada , Literatura de Revisão como Assunto , Bases de Dados Bibliográficas
7.
Rev. cuba. cir ; 60(2): e989,
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1280220

RESUMO

Introducción: El cáncer de colon constituye un grave problema sanitario debido a su alta incidencia y mortalidad. Objetivo: Describir algunos aspectos epidemiológicos, etiopatogénicos, diagnósticos, terapéuticos y evolutivos del cáncer de colon con metástasis hepáticas. Métodos: Revisión documental en bases de datos bibliográficos biomédicas sobre el tema durante el período 2015-2020. Se seleccionaron 31 artículos relacionados con el objetivo propuesto. Desarrollo: Los pacientes con cáncer de colon con metástasis hepáticas sincrónicas son tratados mediante tres estrategias: la tradicional o clásica consiste en la resección quirúrgica del tumor primario y posteriormente, quimioterapia, radioterapia o ambas, para proceder a la resección de las lesiones hepáticas tres a seis meses después; la simultánea, consistente en la resección de la lesión tumoral primaria y de las metástasis hepáticas en un mismo acto quirúrgico, seguida de quimioterapia, radioterapia o ambas y la inversa, que administra de tres a seis ciclos de quimioterapia sistémica, seguidos por la resección de las metástasis hepáticas y en un segundo tiempo resecar el tumor primario, todo esto con quimioterapia durante el intervalo entre ambas cirugías. Conclusiones: El único tratamiento con potencial curativo en los pacientes con metástasis hepáticas debe ser la resección de todo el volumen tumoral hepático con márgenes adecuados y la suficiente preservación del parénquima sano (25 - 30 por ciento), según criterios oncológicos y anatómicos establecidos, lo que incide en la calidad de vida y la supervivencia de estos enfermos(AU)


Introduction: Colon cancer is a serious health concern due to its high incidence and mortality. Objective: To describe some epidemiological, etiopathogenic, diagnostic, therapeutic and evolutionary aspects of colon cancer with hepatic metastases. Methods: Documentary review about the subject carried out in biomedical bibliographic databases, during the period 2015-2020. Thirty-one articles related to the proposed objective were selected. Development: Colon cancer patients with synchronous hepatic metastases are treated using three strategies: the traditional, or classic, strategy consists in surgical resection of primary tumor and, subsequently, chemotherapy, radiotherapy or both, before proceeding then to resection of liver lesions three to three six months later; the simultaneous strategy consists in resection of primary tumor lesion and hepatic metastases in the same surgical procedure, followed by chemotherapy, radiotherapy or both; and the reverse strategy, in which three to six cycles of systemic chemotherapy are administered, followed by resection of hepatic metastases and, in a second stage, resection of primary tumor, all this with chemotherapy during the interval between both surgeries. Conclusions: The only treatment with curative potential in patients with hepatic metastases should be the resection of the entire hepatic tumor volume with adequate margins and sufficient preservation of the healthy parenchyma (25-30 percent), according to established oncological and anatomical criteria, which has an incidence on the quality of life and survival of these patients(AU)


Assuntos
Humanos , Qualidade de Vida , Bases de Dados Bibliográficas , Neoplasias do Colo/cirurgia , Neoplasias do Colo/epidemiologia , Metástase Neoplásica/terapia , Sobrevivência , Fígado/lesões
8.
Rev. cuba. estomatol ; 58(2): e3154, 2021. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1289406

RESUMO

Introducción: La recesión gingival es uno de los defectos estético-funcionales más comunes en la cavidad oral. Se caracteriza por la exposición de la superficie de la raíz debido a un desplazamiento del margen gingival apical a la unión amelocementaria. La literatura reporta un porcentaje de recubrimiento de la raíz favorable en recesiones gingivales clases I y II de Miller; sin embargo, varios estudios no lograron el recubrimiento total, lo que ha sido asociado a varios factores. Objetivo: Identificar los factores asociados al recubrimiento total de recesiones gingivales clases I y II de Miller en dientes tratados con colgajo de reposición coronal. Métodos: Se consultaron las bases de datos PubMed SciELO, Redalyc, Lilacs y Scopus. De 105 investigaciones, se analizaron 7 que cumplieron los criterios de inclusión. Análisis e integración de las informaciones: El metaanálisis dio resultados no concluyentes, debido a la alta heterogeneidad de los estudios. Sin embargo, se detectaron los siguientes factores: el uso de ácido etilendiaminotetraacético (p < 0,0001), la presencia de tejido queratinizado adjunto ≥ 2 mm (p = 0,019), una profundidad de recesión gingival inicial > 3 mm (p = 0,020) y pacientes que fumaban más de 10 cigarrillos diarios (p < 0,05). Conclusiones: Se identificaron el uso de ácido etilendiaminotetracético, la presencia de tejido queratinizado, la profundidad de la recesión y pacientes fumadores como posibles factores que intervienen el recubrimiento total de recesiones gingivales clases I y II de Miller en dientes tratados con colgajo de reposición coronal(AU)


Introduction: Gingival recession is one of the most common esthetic-functional defects of the oral cavity. It is characterized by exposure of the root surface due to displacement of the apical gingival margin to the cementoenamel junction. The literature about the topic reports a percentage of favorable root coverage of Miller class I and II gingival recessions. However, several studies do not report complete coverage, which has been associated to a number of factors. Objective: Identify the factors associated to complete coverage of Miller class I and II gingival recessions in teeth treated with coronally repositioned flap. Methods: A search was conducted in the databases PubMed, SciELO, Redalyc, Lilacs and Scopus. Of a total 105 studies retrieved, seven met the inclusion criteria. Data analysis and integration: The meta-analysis did not achieve conclusive results, due to the high heterogeneity of the studies. However, the following factors were identified: use of ethylenediaminetetraacetic acid (p < 0.0001), presence of adjacent keratinized tissue ≥ 2 mm (p = 0.019), initial gingival recession depth > 3 mm (p = 0.020) and patients who smoked more than 10 cigarettes a day (p < 0.05). Conclusions: Use of ethylenediaminetetraacetic acid, presence of keratinized tissue, recession depth and smoker patients were identified as possible factors involved in the complete coverage Miller class I and II gingival recessions in teeth treated with coronally repositioned flap(AU)


Assuntos
Humanos , Fatores de Risco , Fumantes , Retração Gengival/epidemiologia , Bases de Dados Bibliográficas
9.
Rev. cuba. estomatol ; 58(2): e3053, 2021. graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1289405

RESUMO

Introducción: Los desórdenes temporomandibulares son un grupo de trastornos que afectan la articulación temporomandibular y/o los tejidos musculoesqueléticos asociados. Objetivo: Determinar la efectividad de los concentrados de plaquetas en el tratamiento de los desórdenes temporomandibulares. Métodos: La búsqueda de la literatura fue realizada desde enero del 2014 hasta abril del 2019, en las bases de datos biomédicas: PubMed, Embase, SciELO, Scopus, Science Direct, Sistema de información sobre literatura gris en Europa, Literatura Latinoamericana y del Caribe en Ciencias de la Salud, Google Académico y el Registro Central de Ensayos Clínicos Cochrane. Se definieron como criterios de selección de los estudios que fueran ensayos clínicos aleatorizados, con una antigüedad máxima de cinco años, que reportarann la efectividad (reducción del dolor y aumento de apertura máxima) de los concentrados plaquetarios en el tratamiento de los desórdenes temporomandibulares. El riesgo de sesgo de los estudios fue analizado por medio del Manual Cochrane de revisiones sistemáticas de intervenciones. Resultados: La estrategia de búsqueda resultó en nueve artículos, de los cuales el 100 por ciento reportó que no había diferencia en la reducción del dolor y el aumento de apertura máxima de los concentrados plaquetarios en el tratamiento de los desórdenes temporomandibulares. Conclusiones: La literatura revisada sugiere que existe una ligera evidencia de los beneficios potenciales de las inyecciones intraarticulares de los concentrados plaquetarios en pacientes con desórdenes temporomandibulares. Sin embargo, es necesario establecer un protocolo estandarizado para la preparación y aplicación de estos concentrados(AU)


Introduction: Temporomandibular disorders are a group of dysfunctions which affect the temporomandibular joint and/or associated musculoskeletal tissues. Objective: Determine the effectiveness of platelet concentrates in the treatment of temporomandibular disorders. Methods: A bibliographic search was conducted from January 2014 to April 2019 in the biomedical databases PubMed, Embase, SciELO, Scopus, Science Direct, System for Information on Gray Literature in Europe, Latin American and Caribbean Health Sciences Literature, Google Scholar, and Cochrane Central Register of Clinical Trials. The following selection criteria were defined for the studies: randomized clinical trials published in the last five years and reporting on the effectiveness (pain reduction and maximum opening increase) of platelet concentrates in the treatment of temporomandibular disorders. Bias risk analysis was based on the Cochrane manual of systematic reviews of interventions. Results: Nine papers were retrieved, of which 100 percent reported no differences in pain reduction or maximum opening increase resulting from the use of platelet concentrates in the treatment of temporomandibular disorders. Conclusions: The literature review conducted suggests that there is slight evidence of the potential benefits of intra-articular injections of platelet concentrates in patients with temporomandibular disorders. However, a standardized protocol should be established for the preparation and application of these concentrates(AU)


Assuntos
Humanos , Transtornos da Articulação Temporomandibular/terapia , Fibrina Rica em Plaquetas , Injeções Intra-Articulares/métodos , Literatura de Revisão como Assunto , Bases de Dados Bibliográficas
11.
Nucleic Acids Res ; 49(W1): W619-W623, 2021 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-34048576

RESUMO

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will be remembered as one of the defining events of the 21st century. The rapid global outbreak has had significant impacts on human society and is already responsible for millions of deaths. Understanding and tackling the impact of the virus has required a worldwide mobilisation and coordination of scientific research. The COVID-19 Data Portal (https://www.covid19dataportal.org/) was first released as part of the European COVID-19 Data Platform, on April 20th 2020 to facilitate rapid and open data sharing and analysis, to accelerate global SARS-CoV-2 and COVID-19 research. The COVID-19 Data Portal has fortnightly feature releases to continue to add new data types, search options, visualisations and improvements based on user feedback and research. The open datasets and intuitive suite of search, identification and download services, represent a truly FAIR (Findable, Accessible, Interoperable and Reusable) resource that enables researchers to easily identify and quickly obtain the key datasets needed for their COVID-19 research.


Assuntos
Pesquisa Biomédica , COVID-19 , Bases de Dados Factuais , Conjuntos de Dados como Assunto , Disseminação de Informação , Publicação de Acesso Aberto , SARS-CoV-2 , COVID-19/epidemiologia , COVID-19/genética , COVID-19/virologia , Bases de Dados Bibliográficas , Surtos de Doenças , Humanos , Pandemias , SARS-CoV-2/química , SARS-CoV-2/genética , SARS-CoV-2/metabolismo , SARS-CoV-2/ultraestrutura , Fatores de Tempo , Proteínas Virais/química , Proteínas Virais/genética
12.
PLoS Biol ; 19(4): e3001162, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33872298

RESUMO

Many randomized controlled trials (RCTs) are biased and difficult to reproduce due to methodological flaws and poor reporting. There is increasing attention for responsible research practices and implementation of reporting guidelines, but whether these efforts have improved the methodological quality of RCTs (e.g., lower risk of bias) is unknown. We, therefore, mapped risk-of-bias trends over time in RCT publications in relation to journal and author characteristics. Meta-information of 176,620 RCTs published between 1966 and 2018 was extracted. The risk-of-bias probability (random sequence generation, allocation concealment, blinding of patients/personnel, and blinding of outcome assessment) was assessed using a risk-of-bias machine learning tool. This tool was simultaneously validated using 63,327 human risk-of-bias assessments obtained from 17,394 RCTs evaluated in the Cochrane Database of Systematic Reviews (CDSR). Moreover, RCT registration and CONSORT Statement reporting were assessed using automated searches. Publication characteristics included the number of authors, journal impact factor (JIF), and medical discipline. The annual number of published RCTs substantially increased over 4 decades, accompanied by increases in authors (5.2 to 7.8) and institutions (2.9 to 4.8). The risk of bias remained present in most RCTs but decreased over time for allocation concealment (63% to 51%), random sequence generation (57% to 36%), and blinding of outcome assessment (58% to 52%). Trial registration (37% to 47%) and the use of the CONSORT Statement (1% to 20%) also rapidly increased. In journals with a higher impact factor (>10), the risk of bias was consistently lower with higher levels of RCT registration and the use of the CONSORT Statement. Automated risk-of-bias predictions had accuracies above 70% for allocation concealment (70.7%), random sequence generation (72.1%), and blinding of patients/personnel (79.8%), but not for blinding of outcome assessment (62.7%). In conclusion, the likelihood of bias in RCTs has generally decreased over the last decades. This optimistic trend may be driven by increased knowledge augmented by mandatory trial registration and more stringent reporting guidelines and journal requirements. Nevertheless, relatively high probabilities of bias remain, particularly in journals with lower impact factors. This emphasizes that further improvement of RCT registration, conduct, and reporting is still urgently needed.


Assuntos
Publicações , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto/estatística & dados numéricos , Viés , Bibliometria , Confiabilidade dos Dados , Gerenciamento de Dados/história , Gerenciamento de Dados/métodos , Gerenciamento de Dados/normas , Gerenciamento de Dados/tendências , Bases de Dados Bibliográficas/história , Bases de Dados Bibliográficas/normas , Bases de Dados Bibliográficas/tendências , História do Século XX , História do Século XXI , Humanos , Avaliação de Resultados em Cuidados de Saúde , Registros Públicos de Dados de Cuidados de Saúde , Publicações/história , Publicações/normas , Publicações/estatística & dados numéricos , Publicações/tendências , Melhoria de Qualidade/história , Melhoria de Qualidade/tendências , Ensaios Clínicos Controlados Aleatórios como Assunto/história , Revisões Sistemáticas como Assunto
13.
Salud(i)ciencia (Impresa) ; 24(5): 238-244, mar.-abr. 2021. tab.
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-1283917

RESUMO

Se realizó una revisión narrativa sobre la genética del hipotiroidismo congénito (HC). Se utilizaron las bases de datos Medline/PubMed, LILACS-BIREME y SciELO. Se identificaron los estudios originales publicados entre 2000 y agosto de 2020. Las palabras clave utilizadas durante la búsqueda fueron las siguientes: "hipotiroidismo congénito (congenital hypothyroidism)", "genética (genetic)", "polimorfismos de nucleótido único (SNP) (single polymorphisms nucleotid)". Se revisaron 58 estudios originales que informan las bases moleculares del HC. Se ha definido el concepto básico del HC, así como las bases moleculares que están asociados con la aparición de dicho trastorno. La revisión de la literatura ha permitido identificar al menos 12 genes que codifican las proteínas, las cuales, al producirse mutaciones, están implicadas en el HC. De los 12 genes informados que desempeñan un papel importante en el HC, errores en 6 genes se han vinculado con el HC con disgenesia tiroidea, lo cual implica alteraciones en la morfogénesis de la glándula tiroides, mientras que mutaciones en otros 6 genes se han asociado con dishormonogénesis, que genera un bloqueo total o parcial de los procesos bioquímicos implicados en la síntesis y secreción de hormonas tiroideas. La prevalencia en Sudamérica varía aproximadamente desde 1 por cada 1170 hasta 1 por cada 8285 neonatos. El estudio de la genética molecular pone de manifiesto que, en el futuro, aportará datos importantes en cuanto a la identificación de nuevas mutaciones y asociaciones con fenotipos clínicos que podrían relacionarse con el HC, para, de esta manera, potenciar el diagnóstico y tratamiento


A narrative review was conducted on the genetics of congenital hypothyroidism. The Medline/PubMed, LILACS-BIREME, and SciELO databases were used. Original studies published between 2000 and August 2020 were identified. The keywords used during the search were as follows: "congenital hypothyroidism", "genetics", "polymorphisms SNPs". Fifty-eight original studies reviewing the molecular basis of congenital hypothyroidism were reviewed. The basic concept of congenital hypothyroidism has been defined as well as the molecular bases that are associated with the development of this disorder. The literature review has identified at least 12 genes encoding proteins that, when mutations occur, are involved in congenital hypothyroidism. Of the 12 genes reported to play an important role in congenital hypothyroidism, errors in 6 genes have been associated with congenital hypothyroidism with thyroid dysgenesis, which implies alterations in the morphogenesis of the thyroid gland. On the other hand, mutations in 6 other genes have been associated with dyshormonogenesis that generates a total or partial blockage of the biochemical processes involved in the synthesis and secretion of thyroid hormones. The prevalence in South America is reported to vary from approximately 1 per 1000 to 1 per 8000 newborns. The study of molecular genetics shows that in the future it will contribute to the identification of new mutations and associations with clinical phenotypes that could be related to congenital hypothyroidism, thus enhancing diagnosis and treatment


Assuntos
Terapêutica , Glândula Tireoide , Hormônios Tireóideos , Epidemiologia , Hipotireoidismo Congênito , Genes , Genética , Bases de Dados Bibliográficas
14.
Femina ; 49(4): 251-256, 20210430.
Artigo em Português | LILACS | ID: biblio-1224096

RESUMO

O diabetes mellitus gestacional (DMG) é uma complicação que atinge o metabolismo da gestante, resultando em intolerância à glicose e consequente hiperglicemia, originada pela insuficiência de insulina materna. Este estudo tem como objetivo identificar os tratamentos disponíveis e mais utilizados para o DMG. Trata-se de um uma revisão de literatura, feita a partir de 22 referências, acerca dos tratamentos para o DMG. As bases de dados escolhidas foram Google Acadêmico, UpToDate, SciELO e o acervo da Universidade do Planalto Catarinense. Estudos apontam a insulina humana ­ NPH e regular ­ como a principal escolha, quando comparada aos seus análogos, apesar de ainda existirem muitas controvérsias quanto ao início do tratamento, o esquema terapêutico e os ajustes das doses. Pesquisas têm demonstrado bons resultados sobre a eficácia e a segurança dos hipoglicemiantes orais ­ gliburida e metformina ­ no tratamento de gestantes diabéticas, mas é evidente a necessidade de mais estudos para confirmar a efetividade deles e garantir um bom desenvolvimento do concepto. Concluiu-se que o controle dietético e o exercício físico são a primeira opção de tratamento para o DMG. Todavia, caso a euglicemia não seja atingida, opta-se pelo tratamento medicamentoso por meio da insulinoterapia ou hipoglicemiantes orais, o que possibilita a redução da incidência dos efeitos adversos ao binômio materno-fetal.(AU)


Gestational diabetes mellitus (DMG) is a complication that affects the pregnant woman's metabolism, resulting in glucose intolerance and consequent hyperglycemia, caused by insufficient maternal insulin. This study aims to identify the available and most used treatments for DMG. This is a literature review, based on 22 references, about treatments for Gestational Diabetes; the databases chosen were Google Scholar, UpToDate, SciELO and the collection of the Universidade do Planalto Catarinense. Studies point to human insulin ­ NPH and regular ­ as the main choice when compared to its analogues, although there are still many controversies about the beginning of treatment, therapeutic scheme and dose adjustments. Researches have shown good results on the efficacy and safety of oral hypoglycemic agents ­ glyburide and metformin ­ in the treatment of diabetic pregnant women, but it is evident the need for further studies to confirm their effectiveness and to guarantee a good development of the fetus. It was concluded that dietary control and physical exercise are the first treatment option for DGM. However, if euglycemia is not achieved, drug treatment is chosen through insulin therapy or oral hypoglycemic agents, which makes it possible to reduce the incidence of adverse effects to the maternal-fetal binomial.(AU)


Assuntos
Humanos , Feminino , Gravidez , Diabetes Gestacional/dietoterapia , Diabetes Gestacional/tratamento farmacológico , Diabetes Gestacional/terapia , Diabetes Mellitus/tratamento farmacológico , Exercício Físico , Bases de Dados Bibliográficas , Glibureto/efeitos adversos , Glibureto/uso terapêutico , Hipoglicemiantes/efeitos adversos , Hipoglicemiantes/uso terapêutico , Insulina/administração & dosagem , Insulina/uso terapêutico , Metformina/efeitos adversos , Metformina/uso terapêutico
15.
Femina ; 49(4): 246-250, 20210430. ilus
Artigo em Português | LILACS | ID: biblio-1224100

RESUMO

Hemorragia pós-parto é a maior causa de histerectomia periparto. Esta revisão descreve e ilustra as técnicas de ligaduras vasculares utilizadas no tratamento cirúrgico da hemorragia pós-parto. São apresentados os detalhes técnicos da ligadura das artérias uterinas, da ligadura das conexões útero-ovarianas, da ligadura tríplice de Tsirulnikov, das ligaduras sequenciais de AbdRabbo e de Morel e da ligadura das artérias ilíacas internas. Também são revistos os fatores que dificultam o sucesso dessas técnicas. As ligaduras vasculares são estratégias eficientes para o controle hemorrágico durante cesarianas e devem integrar o conjunto de técnicas que preservam o útero no tratamento da hemorragia pós-parto.(AU)


Postpartum hemorrhage is the major cause of peripartum hysterectomy. This review describes and illustrates the techniques of vascular ligations used in the surgical treatment of postpartum hemorrhage. The technical details of the uterine arteries ligation, of the ligation of the utero-ovarian connections, of the Tsirulnikov triple ligation, of the AbdRabbo and Morel sequential ligations and of the internal iliac arteries ligation are presented. The factors that hinder the success of these techniques also are reviewed. Vascular ligations are efficient strategies for hemorrhagic control during cesarean sections and should integrate the set of techniques that preserve the uterus in the treatment of postpartum hemorrhage.(AU)


Assuntos
Humanos , Feminino , Gravidez , Artéria Uterina/cirurgia , Hemorragia Pós-Parto/cirurgia , Ligadura/métodos , Bases de Dados Bibliográficas , Preservação da Fertilidade/métodos , Hemorragia Pós-Parto/mortalidade
16.
Biosci Trends ; 15(2): 64-73, 2021 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-33746182

RESUMO

Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has affected tens of millions of people globally since it was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. There is an urgent need for safe and effective preventive vaccines to curb this pandemic. A growing amount of related research has been published. This study aimed to provide the current status of COVID-19 vaccine using bibliometric analysis. We searched Embase.com and MEDLINE comprehensively and included articles, articles in press, reviews, short surveys, conference abstracts and conference papers about COVID-19 vaccine. VOSviewer1.6.11 (Leiden University, Leiden, Netherlands) was applied to perform the bibliometric analysis of these papers. A total of 1,312 papers were finally included. The BMJ has been the most popular journal in this field. The United States maintained a top position worldwide and has provided a pivotal influence, followed by China, India and United Kingdom. Among all the institutions, Harvard University was regarded as a leader for research collaboration. We analyzed the keywords and identified seven COVID-19 vaccine research hotspot clusters. COVID-19 vaccine research hotspots focus on clinical trials on vaccine safety and efficacy, research on vaccine immunology and immunoinformatics, and vaccine hesitancy. Our analysis results demonstrated that cooperation between countries, institutions, and authors were insufficient. The results suggested that clinical trials on vaccine safety, efficacy, immunology, immunoinformatics, production and delivery are research hotspots. Furthermore, we can predict that there will be a lot of research focusing on vaccine adverse reactions.


Assuntos
Bibliometria , Vacinas contra COVID-19 , COVID-19/prevenção & controle , Pandemias/prevenção & controle , SARS-CoV-2 , Pesquisa Biomédica/tendências , COVID-19/epidemiologia , COVID-19/imunologia , Vacinas contra COVID-19/efeitos adversos , Vacinas contra COVID-19/imunologia , Vacinas contra COVID-19/farmacologia , Bases de Dados Bibliográficas , Humanos , MEDLINE , SARS-CoV-2/imunologia , Segurança
17.
Einstein (Sao Paulo) ; 19: eAO6002, 2021.
Artigo em Inglês, Português | MEDLINE | ID: mdl-33729287

RESUMO

OBJECTIVE: To carry out a scoping review of the meta-analyses published regarding about coronavirus disease 2019 (COVID-19), evaluating their main characteristics, publication trends and methodological quality. METHODS: A bibliometric search was performed in PubMed®, Scopus and Web of Science, focusing on meta-analyses about COVID-2019 disease. Bibliometric and descriptive data for the included articles were extracted and the methodological quality of the included meta-analyses was evaluated using A Measurement Tool to Assess Systematic Reviews. RESULTS: A total of 348 meta-analyses were considered eligible. The first meta-analysis about COVID-19 disease was published on February 26, 2020, and the number of meta-analyses has grown rapidly since then. Most of them were published in infectious disease and virology journals. The greatest number come from China, followed by the United States, Italy and the United Kingdom. On average, these meta-analyses included 23 studies and 15,200 participants. Overall quality was remarkably low, and only 8.9% of them could be considered as of high confidence level. CONCLUSION: Although well-designed meta-analyses about COVID-19 disease have already been published, the majority are of low quality. Thus, all stakeholders playing a role in COVID-19 deseases, including policy makers, researchers, publishers and journals, should prioritize well-designed meta-analyses, performed only when the background information seem suitable, and discouraging those of low quality or that use suboptimal methods.


Assuntos
Bibliometria , COVID-19 , China , Bases de Dados Bibliográficas , Humanos , Itália , Metanálise como Assunto , Revisões Sistemáticas como Assunto , Reino Unido , Estados Unidos
18.
Femina ; 49(3): 183-186, 20210331.
Artigo em Português | LILACS | ID: biblio-1224086

RESUMO

Os autores apresentam a evolução histórica dos caminhos percorridos até a criação do primeiro programa público de interrupção legal da gestação no Brasil. Mencionam o atendimento antes desse programa, que era realizado por poucos, de maneira dissimulada e sem publicidade nem publicações para a preservação das equipes. Mencionam como o Hospital Municipal Dr. Arthur Ribeiro de Saboya foi escolhido para esse desafio. Resgatam a luta das mulheres e dos movimentos feministas, e a criação da portaria que determinava a obrigatoriedade do atendimento para a realização do abortamento legal nos casos de antijuricidade, pela Prefeitura Municipal de São Paulo. Mencionam os difíceis caminhos até a constituição das equipes de atendimento e o desenrolar de uma sequência de fatos históricos, passando pelo início do atendimento imediato às vítimas no sentido de realizar as profilaxias pertinentes, a utilização de aspiração manual intrauterina (AMIU) como técnica principal para atendimento ao abortamento em todas as suas situações, os Fóruns Nacionais de Aborto Legal realizados pelo Cemicamp, Ministério da Saúde e Federação Brasileira das Associações de Ginecologia e Obstetrícia (Febrasgo), entre outros, que culminaram com tudo o que temos hoje em termos de atendimento integral à saúde da mulher, mormente no que tange aos direitos sexuais e reprodutivos, à violência sexual e à interrupção legal da gestação.(AU)


The authors present the historical evolution of the paths traveled until the creation of the First Public Program for Legal Interruption of Pregnancy in Brazil. They mention the care before this program that was carried out by a few, in a covert way and without advertisements or publications for the preservation of the team. Mention as the Municipal Hospital Dr. Arthur Ribeiro de Saboya was chosen for this challenge. They rescued the struggle of women and feminist movements, the creation of the ordinance that determined the mandatory care for the performance of legal abortion in cases of anti-juristy, by the city of São Paulo. They mention the difficult paths to the constitution of care teams and the development of a sequence of historical facts, through the beginning of immediate care to victims in order to perform the relevant prophylaxis, in the use of the AMIU as the main technique for abortion care in all its situations, the National Legal Abortion Forums held by Cemicamp, Ministry of Health and Federação Brasileira das Associações de Ginecologia e Obstetrícia (Febrasgo), among others, which culminated in all that we have today in terms of comprehensive care for women's health, especially with regard to sexual and reproductive rights, sexual violence and legal interruption of pregnancy.(AU)


Assuntos
Humanos , Feminino , Gravidez , História do Século XX , Aborto Legal/história , Aborto Legal/legislação & jurisprudência , Aborto Legal/métodos , Programas Governamentais/história , Estupro/legislação & jurisprudência , Brasil , Bases de Dados Bibliográficas , Portarias , Violência contra a Mulher
19.
Rev. cuba. oftalmol ; 34(1): e929, 2021. graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1289535

RESUMO

La queratitis por Acanthamoeba es una infección corneal de baja incidencia, condicionada por varios factores, pero con manifestación clínica variada y sintomatología típica. En su fase epitelial debe ser diferenciada de otras queratitis, específicamente de la queratitis por herpes simple, por la similitud entre ambas en cuanto a las características de la lesión corneal. La microscopia confocal in vivo constituye una alternativa diagnóstica. Es una biopsia fotográfica en cuyas imágenes podemos describir los quistes y trofozoítos de Acanthamoeba desde etapas iniciales, que nos ayudan a diferenciarla de otros tipos de queratitis e iniciar el tratamiento precoz. Se realizó una búsqueda de artículos publicados, con el objetivo de mostrar las imágenes por microscopia confocal de la fase epitelial de la infección corneal por Acanthamoeba y herpes simple. Se utilizó la plataforma Infomed, específicamente la Biblioteca Virtual de Salud(AU)


Acanthamoeba keratitis is a low-incidence corneal infection caused by several factors and characterized by a variety of clinical manifestations and typical symptoms. In its epithelial phase, it should be differentiated from other keratitis, particularly from herpes simplex keratitis, due to the similar characteristics of the corneal lesion. In vivo confocal microscopy is a diagnostic alternative consisting in a photographic biopsy showing images of Acanthamoeba cysts and trophozoites since their initial stages, thus allowing differentiation from other types of keratitis and the initiation of early treatment. A search was conducted of published papers with the purpose of showing confocal microscopy images of the epithelial phase of Acanthamoeba and herpes simplex corneal infection. Use was made of the platform Infomed, specifically the Virtual Health Library(AU)


Assuntos
Humanos , Ceratite por Acanthamoeba/epidemiologia , Ceratite Herpética/diagnóstico por imagem , Microscopia Confocal/métodos , Literatura de Revisão como Assunto , Bases de Dados Bibliográficas
20.
Rev. ADM ; 78(2): 84-89, mar.-abr. 2021. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-1247548

RESUMO

Objetivo: Identificar y analizar en la literatura científica reciente el uso de la oximetría de pulso como método diagnóstico de vitalidad pulpar. Metodología: En este trabajo se llevó a cabo una revisión de la literatura en las plataformas de PubMed y Google Académico, en la cual se analizó el uso de la oximetría de pulso en el diagnóstico y monitoreo odontológico del estado pulpar. Resultados: Después de una exhaustiva revisión, y de acuerdo con los criterios de inclusión y exclusión, se analizaron 21 artículos. La mayoría de los trabajos consideran la oximetría de pulso un método alternativo de diagnóstico indoloro, seguro y eficaz; sin embargo, la adaptación de un instrumento de uso exclusivo odontológico es necesaria para una medición exacta de la saturación de oxígeno en la pulpa dental. Los avances tecnológicos en el campo clínico de la odontología nos han llevado a la búsqueda de nuevas técnicas diagnósticas clínicas para mejorar la atención y los tratamientos de los pacientes que acuden día con día a recibir una consulta odontológica. Conclusiones: En los últimos años la oximetría de pulso ha demostrado ser una herramienta de diagnóstico eficaz para el diagnóstico de la vitalidad pulpar. El análisis de los artículos incluidos en esta revisión concluye que la oximetría de pulso es una técnica innovadora que puede ser utilizada como una herramienta diagnóstica adyuvante en el diagnóstico de la vitalidad pulpar (AU)


Objective: To identify and analyze in the recent scientific literature the use of pulse oximetry as a diagnostic method for pulp vitality. Methodology: In this work, a literature review was carried out on the PubMed and Google Scholar platforms in which the use of pulse oximetry in the dental diagnosis and monitoring of pulp status was analyzed. Results: After an exhaustive review and in accordance with the inclusion and exclusion criteria, 21 articles were analyzed. Most of the studies consider pulse oximetry an alternative method of painless, safe and effective diagnosis, however, the adaptation of an instrument for exclusive dental use is necessary for an exact measurement of the oxygen saturation in the dental pulp. Technological advances in the clinical field of dentistry have led us to search for new clinical diagnostic techniques to improve the care and treatment of patients who come every day to receive a dental consultation. Conclusions: In recent years, pulse oximetry has proven to be an effective diagnostic tool for the diagnosis of pulp vitality. The analysis of the articles included in this review concludes that pulse oximetry is an innovative technique that can be used as an adjunct diagnostic tool in the diagnosis of pulp vitality (AU)


Assuntos
Humanos , Pulpite/diagnóstico , Oximetria , Teste da Polpa Dentária/métodos , Nível de Oxigênio , Diagnóstico Clínico , Bases de Dados Bibliográficas , Sensibilidade e Especificidade , PubMed , Cavidade Pulpar
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