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2.
Chem Soc Rev ; 50(10): 5850-5862, 2021 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-34027942

RESUMO

This tutorial review focuses on recent advances in technologies for enzyme immobilisation, enabling their cost-effective use in the bio-based economy and continuous processing in general. The application of enzymes, particularly in aqueous media, is generally on a single use, throw-away basis which is neither cost-effective nor compatible with a circular economy concept. This shortcoming can be overcome by immobilising the enzyme as an insoluble recyclable solid, that is as a heterogeneous catalyst.


Assuntos
Biotecnologia/economia , Enzimas Imobilizadas/metabolismo , Biocatálise , Enzimas Imobilizadas/química , Reutilização de Equipamento , Grafite/química , Lipase/química , Lipase/metabolismo , Magnetismo , Estruturas Metalorgânicas/química
4.
Nat Biotechnol ; 39(10): 1300-1307, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34002098

RESUMO

The scientific ecosystem relies on citation-based metrics that provide only imperfect, inconsistent and easily manipulated measures of research quality. Here we describe DELPHI (Dynamic Early-warning by Learning to Predict High Impact), a framework that provides an early-warning signal for 'impactful' research by autonomously learning high-dimensional relationships among features calculated across time from the scientific literature. We prototype this framework and deduce its performance and scaling properties on time-structured publication graphs from 1980 to 2019 drawn from 42 biotechnology-related journals, including over 7.8 million individual nodes, 201 million relationships and 3.8 billion calculated metrics. We demonstrate the framework's performance by correctly identifying 19/20 seminal biotechnologies from 1980 to 2014 via a blinded retrospective study and provide 50 research papers from 2018 that DELPHI predicts will be in the top 5% of time-rescaled node centrality in the future. We propose DELPHI as a tool to aid in the construction of diversified, impact-optimized funding portfolios.


Assuntos
Bibliometria , Pesquisa Biomédica/estatística & dados numéricos , Aprendizado de Máquina , Pesquisa Biomédica/economia , Pesquisa Biomédica/tendências , Biotecnologia/economia , Biotecnologia/estatística & dados numéricos , Biotecnologia/tendências , Humanos , Fator de Impacto de Revistas , Reconhecimento Automatizado de Padrão , Fatores de Tempo
5.
Cells ; 10(5)2021 04 25.
Artigo em Inglês | MEDLINE | ID: mdl-33923045

RESUMO

Ubiquitination is a post-translational modification that has pivotal roles in protein degradation and diversified cellular processes, and for more than two decades it has been a subject of interest in the biotech or biopharmaceutical industry. Tripartite motif (TRIM) family proteins are known to have proven E3 ubiquitin ligase activities and are involved in a multitude of cellular and physiological events and pathophysiological conditions ranging from cancers to rare genetic disorders. Although in recent years many kinds of E3 ubiquitin ligases have emerged as the preferred choices of big pharma and biotech startups in the context of protein degradation and disease biology, from a surface overview it appears that TRIM E3 ubiquitin ligases are not very well recognized yet in the realm of drug discovery. This article will review some of the blockbuster scientific discoveries and technological innovations from the world of ubiquitination and E3 ubiquitin ligases that have impacted the biopharma community, from biotech colossuses to startups, and will attempt to evaluate the future of TRIM family proteins in the province of E3 ubiquitin ligase-based drug discovery.


Assuntos
Biotecnologia/economia , Indústrias/economia , Processamento de Proteína Pós-Traducional , Proteínas com Motivo Tripartido/metabolismo , Ubiquitina-Proteína Ligases/metabolismo , Ubiquitina/metabolismo , Ubiquitinação , Biotecnologia/estatística & dados numéricos , Humanos , Domínios Proteicos
9.
PLoS One ; 16(1): e0243813, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33406113

RESUMO

We compared the financial performance of 319 BIOTECH companies focused on developing therapeutics with IPOs from 1997-2016, to that of paired, non-biotech CONTROL companies with concurrent IPO dates. BIOTECH companies had a distinctly different financial structure with high R&D expense, little revenue, and negative profits (losses), but a similar duration of listing on public markets and frequency of acquisitions. Through 2016, BIOTECH and CONTROL companies had equivalent growth in market cap and shareholder value (>$100 billion), but BIOTECH companies had lower net value creation ($93 billion vs $411 billion). Both cohorts exhibited a high-risk/high reward pattern of return, with the majority losing value, but many achieving growth multiples. While investments in biotechnology are often considered to be distinctively risky, we conclude that value creation by biotech companies after IPO resembles that of non-biotech companies at a similar stage and does not present a disproportionate investment risk.


Assuntos
Biotecnologia/economia , Investimentos em Saúde/economia , Estimativa de Kaplan-Meier , Pesquisa , Fatores de Tempo
11.
N Biotechnol ; 61: 40-49, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33152528

RESUMO

Bioeconomy has been proposed as a strategy to overcome many global and national challenges, from climate action to income diversification in rural areas. Therefore, the ultimate goal is not to measure the bioeconomy per se, but its sustainability. One way to ensure sustainability of bioeconomy strategies would be by linking its reporting with internationally-agreed targets of Sustainable Development Goals (SDGs) of the United Nations. Although there are case studies, scientific articles and technical reports in the literature of bioeconomy and other related strategies (e.g. green economy, circular economy) and their links to SDGs, the complete picture on this heterogeneous literature is missing. The objective of this work is to lay out the opportunities to couple monitoring and evaluation of bioeconomy and bioeconomy-related concepts to aid the countries to report their status on attaining SDGs. This study is the first to review and harmonize the results through meta-analysis of the available literature and technical reports on linking bioeconomy and SDGs. The results suggest that bioeconomy monitoring and evaluation can provide opportunities in terms of SDG reporting, in all three dimensions of sustainability. Bioeconomy strategies and practices were found to have strong potential in coupled reporting with several SDGs related to economic development, access to basic services, and sustainable consumption, followed by biodiversity conservation, waste re-use, equality, gender equality, inclusiveness and international cooperation.


Assuntos
Biotecnologia/economia , Conservação dos Recursos Naturais/economia , Desenvolvimento Sustentável/economia , Humanos
12.
N Biotechnol ; 61: 1-8, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33161130

RESUMO

This article presents the current status of the development of bioeconomy in the Czech Republic. Although the country has no unified strategy on bioeconomy, there are ambitious governmental innovation strategies and focused strategies for each region. Traditionally, the country has had a strong research performance in chemistry and biology, which together with developed agriculture, forestry and food industries, provides a good foundation for the development of locally based circular systems. Moreover, the government supports research on tools and applications of new plant breeding technologies, including genome editing, and there is a strong initiative from the research community calling to update EU regulatory policy in this area.


Assuntos
Biotecnologia/economia , Conservação dos Recursos Naturais/economia , Agricultura/economia , República Tcheca , Desenvolvimento Econômico , União Europeia , Indústria Alimentícia/economia , Agricultura Florestal/economia
13.
N Biotechnol ; 61: 99-107, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33249179

RESUMO

The bioeconomy is a new and essential paradigm for reducing our dependence on natural resources and responding to the environmental threats that the Earth is currently facing. In this regard, microalgae offer almost unlimited possibilities for developing a modern bioeconomy given their metabolic flexibility and high biomass output rates, even when produced under harsh conditions, such as when treating wastewaters or using flue gases. In this article, the microalgal contribution to important economic activities such as the production of food and feed, cosmetics and health-related compounds is reviewed. Moreover, potential contributions of microalgae to emerging sectors are discussed, as in the production of biomaterials, agriculture-related products, biofuels and provision of services such as wastewater treatment and the clean-up of industrial gases. The different microalgal production technologies have also been analyzed to identify the main bottlenecks affecting microalgal use in different applications. Finally, the major challenges facing microalgal biotechnology in enlarging its contribution to the bioeconomy are evaluated, and future trends discussed.


Assuntos
Biotecnologia/economia , Microalgas/metabolismo , Agricultura/economia , Biocombustíveis/economia , Biomassa
14.
N Biotechnol ; 61: 57-68, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33220518

RESUMO

The transition to a sustainable bioeconomy by a customized approach would speed up its development and make it more targeted. There is still no common international method for determining, measuring and comparing the extent of sustainability. The aim of this research is to develop a methodology for the assessment of bioeconomy-influencing factor interlinkages, and creation of benchmarks through a top-down approach. The main output is the assessment of factor interlinkages that could be further used for composite index creation. A case of triple factor nexus is presented: policy, research and innovations, and technology nexus for EU countries. As a result, the empirical model presents the mathematical description of policy, research and innovation, and technology link benchmark.


Assuntos
Biotecnologia/economia , Conservação dos Recursos Naturais/economia , Indicadores e Reagentes/economia , Fatores de Transcrição/análise , Tomada de Decisões , Desenvolvimento Econômico
15.
N Biotechnol ; 61: 50-56, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33220519

RESUMO

Bioeconomy is becoming the main driver transforming European agri-food value chains towards global sustainability in the food supply chain. Intensive horticultural production systems based on medium and low-tech greenhouses are suitable scenarios implementing bioeconomy strategies to achieve sustainability targets. Since the publication of the European Strategy of Bioeconomy in 2012, policy measures intended to boost bioeconomy are responsible for changing what are now considered outdated production systems to more high-tech models capable of responding to climate-change challenges. This article describes the potential for the agri-food supply chain to drive the transition of medium and low-tech intensive greenhouse systems to biobased, circular economy value-chains. Key areas of impact relate to waste valorisation and management, new inputs based on biotechnological innovations, building clusters of innovative delivery partners within the sector, and the increase in public awareness of the impact of the bioeconomy through socio-economic analysis.


Assuntos
Biotecnologia/economia , Conservação dos Recursos Naturais/economia , Horticultura/economia , Desenvolvimento Econômico , Espanha
16.
N Biotechnol ; 61: 108-115, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33221394

RESUMO

Development of affordable and low carbon biobased manufacturing depends critically on strategies that reduce cost and emission profiles. This paper indicates that efforts around the reduction of capital costs by intensification of process equipment need to be carefully weighed against the inherently fast increasing financial and climate costs of driving forces used for the intensification. The fundamental relation between capital expenditures (CAPEX) and operational expenditures (OPEX) of intensified and non-intensified biobased processes and their financial and climatic impacts are emphasized and provisionally explored for a few industrial processes. General learnings flag the importance in particular of OPEX minimisation for sustainable bio-economic development.


Assuntos
Biotecnologia/economia , Custos e Análise de Custo/economia
17.
Trends Biotechnol ; 39(6): 542-545, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33246659

RESUMO

Circular bioeconomy is gaining prominence in academic, policy, and industry contexts, linking circular economy and bioeconomy agendas in service of sustainability. However, it is at risk of developing in narrow, unsustainable ways. A sustainable path to circular bioeconomies must embrace diverse expert and stakeholder input, multiple solutions, and noneconomic value.


Assuntos
Biotecnologia , Desenvolvimento Sustentável , Biotecnologia/economia , Indústrias/economia , Políticas , Desenvolvimento Sustentável/economia
18.
Dev World Bioeth ; 21(1): 31-35, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33210409

RESUMO

The ethical concept of justice, as it relates to the development and deployment of innovative health technologies, commands the fair and equitable distribution of burdens and benefits. In bioethics, specific guidance on practical strategies for achieving what this concept of justice demands are somewhat elusive. Drawing on issues of justice arising or likely to arise in the context of the search for a vaccine or cure for COVID-19, this paper argues for a focus on the concept of "practical justice" in post-pandemic bioethics work. To illustrate the value and promise of this concept, the paper reflects on an approach to achieving practical justice in health biotechnology research that is grounded in a commitment to offer technical assistance to developing and under-resourced nations.


Assuntos
Bioética , Pesquisa Biomédica/ética , Biotecnologia/economia , COVID-19/prevenção & controle , Saúde Global/economia , Saúde Global/ética , Justiça Social , Fortalecimento Institucional , Países Desenvolvidos/economia , Países em Desenvolvimento/economia , Humanos
19.
N Biotechnol ; 61: 22-28, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33197617

RESUMO

Continuous, inspiring and interconnected step-by-step changes in thought and understanding, knowhow, actions and behaviour have often been instrumental in transitions from one particular age to the next in human history. This also applies to the present century and its sustainability challenges at the planetary, regional and local levels. Therefore, it is of great importance and relevance to move forward on the journey which has been started globally to address the not insignificant number of challenges. It is however essential to go beyond descriptive work by continuing with novel, inspiring and interconnected steps to find solutions to overcome these challenges. As this huge task also requires multidimensional communication, understanding and actions across different regions, cultures, disciplines and knowledge areas, the development of a common conceptual framework such as the concept of bioeconomy has been accepted globally as very valuable. The momentum which has been created in more than 50 countries around the world by the growing number of activities, initiatives and strategies in bioeconomy is very encouraging. This offers great opportunities to mobilize even more stakeholders in science and industry, as well as society, to join the bioeconomy journey. Strategic high-level concepts such as preserving the value of the natural capital of planet earth, connecting economy and ecology, sustaining the boundary conditions and habitability of our biosphere are highly important. It is also essential on the bioeconomy journey to connect with highly specific and actionable missions, programs and plans towards sustainable economic growth under the boundary conditions of our planet.


Assuntos
Biotecnologia/economia , Conservação dos Recursos Naturais/economia , Desenvolvimento Econômico , Humanos
20.
N Biotechnol ; 60: 2-8, 2021 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-32835869

RESUMO

Bioeconomy is not an autonomous sector of the economy, but rather a complex mechanism involving agriculture, industry, biotechnology, service sectors and consumers. To measure the size of the bioeconomy in European Union (EU) countries, it is necessary to create appropriate indicators that allow it to be monitored with reference to its current state, growth rate and sector description. In many countries, including Poland, there is no complete information or data collection system to monitor bioeconomy development directly, e.g. in the Polish Central Statistical Office. In response to these needs, several groups of indicators related to the circular economy, sustainable development and Europe 2020 were created by the European Commission (EC) in the Eurostat database. These indicators can help monitoring of bioeconomy development in EU countries. The present study discusses factors for bioeconomy development through an analysis of their social, economic and environmental aspects, as well as showing the value of the selected indicators in the EU and Poland. In addition, a separate section is dedicated to public perception of bioeconomy and to legislation regarding genetically modified organisms (GMOs). To date, many research studies have been reported on the public acceptance of bioeconomy issues in the EU, including renewable resources, biofuels, GMOs, bio-based products, food security and climate change. The awareness and perception of society on the bioeconomy, bio-based products and processes, and the sustainable use of resources can contribute to environmental sustainability, but intensified efforts are required to increase public acceptance.


Assuntos
Biotecnologia/economia , Desenvolvimento Econômico , União Europeia/economia , Polônia
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