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1.
Medicine (Baltimore) ; 100(4): e23753, 2021 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-33530174

RESUMO

ABSTRACT: To evaluate the utility of low-concentration nitrous oxide (N2O) anesthesia in ptosis surgeryThis study was a retrospective consecutive case series that included 54 successive patients with blepharoptosis who underwent bilateral levator aponeurosis advancement and on whom skin resection performed by the same surgeon between August 2016 and July 2017. Among these patients, 27 were operated with a local anesthesia injection (air group) and 27 with a local anesthesia injection and low-concentration N2O anesthesia (N2O group). All N2O cases used a total of 6 L of gas comprising 70% oxygen and 30% N2O. Preoperative and postoperative blood pressure (BP) and heart rate (HR) and intraoperative pain, anxiety, nausea, and memory were measured immediately after surgery using visual analog scale score (VASS). Additionally, perioperative side effects were examined.There was no significant difference in age, sex, and preoperative and postoperative margin reflex distance (MRD) between the 2 groups (all P > .05). The intraoperative mean peripheral oxygen saturation was significantly higher (97.5% ±â€Š1.6% vs 99.5% ±â€Š.6%, P < .001), intraoperative HR was significantly lower (78.2 ±â€Š12.8 vs 70.7 ±â€Š11.6 bpm, P = .02), and operation time was significantly shorter (33.1 ±â€Š8.1 vs 29.4 ±â€Š10.3 minutes, P = .03) in the N2O group than in the air group.Difference between intraoperative and preoperative systolic BP (BPs) (+15.8 ±â€Š18.0 vs + 3.1 ±â€Š21.7 mm Hg, P = .02), diastolic BP (BPd) (+7.0 ±â€Š17.4 vs -2.3 ±â€Š13.6 mm Hg, P = .04), and HR (3.2 ±â€Š8.5 vs -3.9 ±â€Š9.4 bpm, P = .01) was significantly lower in the N2O group than in the air group.VASS of intraoperative pain was significantly lower in the N2O group than in the air group (49.5 ±â€Š24.7 vs 22.6 ±â€Š14.9, P < .001), whereas intraoperative anxiety and memory did not present significant differences between the groups (P = .09 and P = .45, respectively). Intraoperative nausea score was 0 for all cases in both groups. There was no other side effect.Ptosis surgery with anesthesia using 30% N2O may effectively suppress intraoperative BP and HR along with pain and shorten the operation time without side effects such as nausea.


Assuntos
Anestésicos Inalatórios/administração & dosagem , Anestésicos Inalatórios/efeitos adversos , Blefaroplastia/métodos , Blefaroptose/cirurgia , Óxido Nitroso/administração & dosagem , Óxido Nitroso/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Anestésicos Locais/administração & dosagem , Ansiedade/prevenção & controle , Pressão Sanguínea/efeitos dos fármacos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Período Intraoperatório , Masculino , Memória/efeitos dos fármacos , Pessoa de Meia-Idade , Náusea/induzido quimicamente , Duração da Cirurgia , Manejo da Dor , Estudos Retrospectivos , Sinais Vitais
2.
BMJ Case Rep ; 14(2)2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33526531

RESUMO

This report describes two patients with acute-onset ptosis, oculomotor dysfunction, ataxia and drowsiness, referable to the midbrain tegmentum. Both patients had previously suffered severe closed head injuries requiring craniotomy for cerebral decompression. Serial brain scans in both cases revealed a newly developing cleft in the midbrain, with features suggestive of abnormal cerebrospinal fluid (CSF) flow across the aqueduct. A trial of acetazolamide was initiated to reduce CSF production, followed by a third ventriculostomy for CSF diversion in one patient, which resulted in arrested disease progression and partial recovery. There are only two previous reports in the literature of midbrain clefts that developed as remote sequelae of head trauma. We postulate that altered CSF flow dynamics in the aqueduct, possibly related to changes in brain compliance, may be contributory. Early recognition and treatment may prevent irreversible structural injury and possible death.


Assuntos
Encefalopatias/diagnóstico por imagem , Lesões Encefálicas Difusas/diagnóstico por imagem , Aqueduto do Mesencéfalo/diagnóstico por imagem , Craniectomia Descompressiva , Traumatismos Cranianos Fechados/cirurgia , Mesencéfalo/diagnóstico por imagem , Acetazolamida/uso terapêutico , Ataxia/fisiopatologia , Blefaroptose , Encefalopatias/fisiopatologia , Encefalopatias/terapia , Lesões Encefálicas Difusas/fisiopatologia , Inibidores da Anidrase Carbônica/uso terapêutico , Líquido Cefalorraquidiano , Progressão da Doença , Disartria/fisiopatologia , Humanos , Hidrodinâmica , Imagem por Ressonância Magnética , Masculino , Transtornos da Motilidade Ocular/fisiopatologia , Ventriculostomia , Adulto Jovem
3.
Am J Case Rep ; 22: e927556, 2021 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-33431787

RESUMO

BACKGROUND Fibrosing mediastinitis is a rarely seen, progressive disease. It results from an excessive fibrotic reaction in the mediastinum. We describe a presentation of fibrosing mediastinitis that, to our knowledge, has never been seen before. CASE REPORT A 30-year-old female Colombian flight attendant presented with a right eyelid droop. Examination revealed partial right-sided ptosis and miosis but no anhidrosis. An ill-defined firm swelling was palpable at the root of the neck. Chest radiography revealed a widened mediastinum, and computerized tomography (CT) showed a right paratracheal mass without calcification extending to the thoracic inlet, encasing multiple blood vessels. All basic blood tests, magnetic resonance imaging of the head, and ultrasound Doppler of the neck vessels were normal. History and work up for infections including fungal diseases, granulomatous diseases, vasculitis, and autoimmune diseases were negative. Positron emission tomography (PET) showed significant FDG uptake in the mediastinum. Mediastinal biopsy was histologically consistent with fibrosing mediastinitis. All relevant immunohistochemistry and microbiological studies were negative. Subsequently, the patient developed signs of superior vena cava compression; this was managed by balloon angioplasty, which resulted in improvement of symptoms. However, over time, her symptoms worsened progressively, resulting in a left-sided ptosis and radiological progression of the mass on CT. She received treatment with rituximab and concomitant steroids, which yielded excellent results: the treatment led to both resolution of her symptoms and regression of the mass and its metabolic activity on PET scan. CONCLUSIONS Fibrosing mediastinitis can present with an incomplete Horner's syndrome. Treatment with rituximab and steroids shows promising results in select cases of metabolically active idiopathic fibrosing mediastinitis.


Assuntos
Blefaroptose/etiologia , Mediastinite/complicações , Mediastinite/diagnóstico , Miose/etiologia , Esclerose/complicações , Esclerose/diagnóstico , Adulto , Feminino , Humanos , Mediastinite/terapia , Esclerose/terapia
4.
Zhongguo Dang Dai Er Ke Za Zhi ; 22(12): 1320-1325, 2020 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-33328004

RESUMO

A boy, aged 2 years and 4 months, had a sudden onset of blepharoptosis of the right eyelid, accompanied by the mouth deviated to the right side, drinking cough, nystagmus, and developmental regression. Cranial MRI showed softening lesions formed after infarction of the right dorsolateral medulla oblongata, while head CT angiography showed no imaging of the proximal part of the V4 segment of the right vertebral artery. The child was diagnosed with dorsolateral medulla oblongata syndrome and was treated with gamma globulin to regulate immune function, with mannitol to reduce neuronal edema, with low-molecular-weight heparin sodium to improve local hypercoagulation of occluded blood vessels, with hyperbaric oxygen to improve local ischemia and hypoxia and promote the recovery of brain function, and with neuromuscular electrical stimulation to promote the recovery of neuromuscular function. Before discharge, only mild right ataxia and Horner syndrome remained. This article reports the first case of infantile dorsolateral medulla oblongata syndrome and provides experience for the diagnosis and treatment of the disease.


Assuntos
Blefaroptose/etiologia , Disartria/etiologia , Síndrome Medular Lateral/diagnóstico , Bulbo/diagnóstico por imagem , Pré-Escolar , Humanos , Síndrome Medular Lateral/complicações , Imagem por Ressonância Magnética , Masculino
7.
Cir. plást. ibero-latinoam ; 46(3): 361-366, jul.-sept. 2020. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-196926

RESUMO

INTRODUCCIÓN Y OBJETIVO: Hoy en día, el uso de toxina botulínica tipo A para el tratamiento de las arrugas glabelares es uno de los procedimientos cosméticos no quirúrgicos más frecuentemente realizados, y la blefaroptosis (ptosis palpebral) es uno de los efectos secundarios adversos que se presenta con más frecuencia en este procedimiento. A través de un estudio retrospectivo presentamos nuestra experiencia y técnica de punción con la que consideramos que hemos reducido de manera significativa la incidencia de la blefaroptosis secundaria al tratamiento de las arrugas glabelares empleando una de las formas de toxina botulínica tipo A disponibles en el mercado. Nuestro objetivo es valorar si el cambio en la técnica de infiltración de los músculos glabelares ha disminuido la incidencia de blefaroptosis en nuestra casuística empleando OnabotulinumtoxinA y manteniendo la misma efectividad terapéutica. MATERIAL Y MÉTODO: Analizamos las fichas clínicas de 2 series consecutivas de 247 pacientes cada una, comparando el resultado obtenido tras la infiltración de los músculos glabelares con una punción paralela y con una punción perpendicular a la zona baja del periostio del hueso frontal. Empleamos en ambas series OnabotulinumtoxinA. RESULTADOS: Los procedimientos con punción perpendicular tuvieron una inidencia de blefaroptosis del 1.22% en comparación con la ausencia de ptosis registrada en los procedimientos con punción paralela. CONCLUSIONES: En nuestra experiencia, la infiltración con punción paralela de OnatolulinumtoxinA para el tratamiento de las arrugas glabelares redujo la incidencia de blefaroptosis, sin afectar a la eficacia del tratamiento


BACKGROUND AND OBJECTIVE: The use of botulinum toxin type A for treating glabellar lines is nowadays one of the most frequent nonsurgical cosmetic procedures, and upper eyelid ptosis (blepharoptosis) is one of the common minor side effects on this procedure. Through a retrospective study we present our experience and puncture technique which we consider has significantly reduced the incidence of upper eyelid ptosis secondary to the treatment of glabellar lines using one of the commercially available forms of botulinum toxin type A. Our aim is to explore whether the change in the form of infiltration of glabellar muscles has decreased the incidence of ptosis in our case series using OnabotulinumtoxinA, maintaining the same therapeutic effectiveness. METHODS: Medical records of 2 consecutive series of 247 patients each where reviewed comparing the results of the treatment of glabellar lines obtained with the infiltration of the glabellar muscles with perpendicular and with parallel puncture of the lower zone of the frontal periosteum. We use OnabotulinumtoxinA in both series. RESULTS: The perpendicular puncture procedure was associated with a ptosis incidence of 1.22%, compared to absence of ptosis with the parallel puncture. CONCLUSIONS: In our experience, parallel infiltration of OnabotulinumtoxinA for the treatment of glabellar lines reduced the incidence of ptosis without affecting the effectiveness of treatment


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Blefaroptose/prevenção & controle , Blefaroptose/terapia , Músculos Oculomotores/efeitos dos fármacos , Toxinas Botulínicas Tipo A/uso terapêutico , Preenchedores Dérmicos/uso terapêutico , Envelhecimento da Pele/efeitos dos fármacos , Blefaroptose/complicações , Estudos Retrospectivos , Intervalos de Confiança , Blefaroptose/epidemiologia
8.
Vestn Oftalmol ; 136(4): 151-155, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32779470

RESUMO

Muller's muscle of the upper eyelid (MM) remains a poorly understood anatomical structure, so its role in the emergence of upper eyelid ptosis provokes certain interest. This literature review examines the gradual rise of attention devoted to MM and describes existing methods of its surgical treatment. Despite progress in ptosis surgery, much remains unsolved. Taking into account the available literature data, it is necessary to further advance histological studying of MM, which will help develop pathogenetically founded surgical treatment of acquired upper eyelid ptosis.


Assuntos
Blefaroptose , Túnica Conjuntiva , Pálpebras , Humanos , Músculo Liso , Músculos Oculomotores
10.
Gene ; 761: 145027, 2020 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-32758583

RESUMO

OBJECTIVES: Oliver-McFarlane syndrome (OMCS) is an autosomal recessive inherited disease resulting from PNPLA6 mutations that results in intellectual impairment and profound short stature. To obtain a better understanding of the genotype-phenotype correlations for PNPLA6-related disorders, we reported the 14th OMCS case and summarized all the reported cases of OMCS. METHODS: We collected clinical biochemical and data and brain MRI data and used whole-exon gene detection and analysis tools to evaluate the pathogenicity of the variants, including PolyPhen-2 and Mutation Taster, and we also generated three-dimensional protein structures and visualized the effects of altered residues with I-TASSER and PyMOL Viewer software. RESULTS: The patient presented with trichomegaly and multiple pituitary hormone deficiencies. Brain MRI showed small pituitary and bilateral paraventricular leukomalacia. Novel variants (c.1491G > T and c.3367G > A) in the PNPLA6 gene were detected in the proband and verified by direct sequencing. Amino acid residues of Gln497 and Gly1123 are predicted to be damaging and destroy the three-dimensional protein structures of the protein. In follow-up, this patient could neither walk nor hold his head erect and had not spoken one word at the age of one year and ten months. Moreover, there is no obvious hot spot mutation in any of the reported allelic variants. Interestingly, the majority of mutations are located in the phospholipid esterase domain, which is responsible for esterase activity. CONCLUSIONS: We identified two novel variants of the PNPLA6 gene in an OMCS patient, which will help to better understand the function of PNPLA6 and genotype-phenotype correlations for PNPLA6-related disorders.


Assuntos
Blefaroptose/diagnóstico , Blefaroptose/genética , Nanismo/diagnóstico , Nanismo/genética , Hipertricose/diagnóstico , Hipertricose/genética , Deficiência Intelectual/diagnóstico , Deficiência Intelectual/genética , Fosfolipases/genética , Retinite Pigmentosa/diagnóstico , Retinite Pigmentosa/genética , Alelos , China , Deficiências do Desenvolvimento/diagnóstico , Deficiências do Desenvolvimento/genética , Frequência do Gene/genética , Estudos de Associação Genética , Genótipo , Humanos , Lactente , Masculino , Mutação , Fenótipo , Fosfolipases/metabolismo
11.
Rinsho Shinkeigaku ; 60(8): 527-532, 2020 Aug 07.
Artigo em Japonês | MEDLINE | ID: mdl-32641625

RESUMO

We describe herein a case with left-side ptosis induced by pure midbrain infarction in a 49-year-old woman. She also presented with diplopia and right-side cerebellar ataxia. MRI demonstrated new ischemic stroke of the left ventral paramedian midbrain. In this case, ischemia of the left oculomotor fascicles caused the left-side ptosis and diplopia, and ischemia of the left decussation of the superior cerebellar peduncle caused the right-side cerebellar ataxia. These symptoms resulted from inner superior medial mesencephalic branch infraction. This case offers an educational example that can be explained by models proposed in the past and requires knowledge of neuroanatomy and cerebrovasculature.


Assuntos
Blefaroptose/etiologia , Infarto Cerebral/complicações , Mesencéfalo/irrigação sanguínea , Feminino , Humanos , Pessoa de Meia-Idade
12.
J Postgrad Med ; 66(3): 162-164, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32675453

RESUMO

Plus-minus lid syndrome is a rare manifestation of midbrain infarct, characterized by ptosis of one eye and lid retraction in the other eye. It has also been described in ocular myasthenia gravis, orbital myositis, or after lesions of the oculomotor nerve. Our patient was a 55-year-old man with hypertension and atrial fibrillation, who presented to us with acute onset left-sided ptosis and right-sided eyelid retraction. He was apathic and had right-sided ataxia. His MRI of the brain showed acute infarct involving the paramedian midbrain. To our knowledge, severe apathy and resultant executive function disorder have not been described previously in a patient having plus-minus lid syndrome with ataxia.


Assuntos
Fibrilação Atrial/complicações , Blefaroptose/etiologia , Hipertensão/complicações , Doenças do Nervo Oculomotor/complicações , Anticoagulantes/administração & dosagem , Apatia , Ataxia , Fibrilação Atrial/tratamento farmacológico , Blefaroptose/fisiopatologia , Infarto Cerebral/complicações , Infarto Cerebral/fisiopatologia , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/administração & dosagem , Hipertensão/tratamento farmacológico , Imagem por Ressonância Magnética , Masculino , Mesencéfalo/irrigação sanguínea , Pessoa de Meia-Idade , Nervo Oculomotor/fisiopatologia , Doenças do Nervo Oculomotor/fisiopatologia , Inibidores da Agregação de Plaquetas/administração & dosagem , Síndrome , Resultado do Tratamento
13.
Curr Opin Ophthalmol ; 31(4): 241-246, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32487809

RESUMO

PURPOSE OF REVIEW: Refractive surgery is one of the most popular elective procedures performed in the world. Given that dry eye is a common complaint following keratorefractive surgery, evaluation, and treatment of periocular conditions that further predispose the patient to dry eye symptoms is an important part of the presurgical assessment. Periocular conditions and surgeries can also affect the ocular surface and keratometry, and should be addressed. For example, ptosis, orbital fat herniation, ectropion, and eyelid masses have been shown to induce corneal topography changes and astigmatism. The oculoplastic considerations for refractive surgery include both the contribution of eyelid position on dry eye, ocular surface damage, refractive error, and outcomes, as well as the timing of oculoplastic surgery in relation to the refractive surgery. In this review, the recently published literature on eyelid and orbital surgery in relation to keratorefractive surgery is reviewed to elucidate the relationship of periocular factors with refractive surgery outcomes and complications. To improve keratorefractive surgery outcomes, a literature review is presented, discussing evaluation, management, and timing of management of oculoplastics conditions. RECENT FINDINGS: Dry eye syndrome is a well known complication of keratorefractive procedures. This is exacerbated with concurrent eyelid or orbital disorders, such as ectropion, lagophthalmos, and thyroid eye disease. In addition to impacting dry eye and ocular surface damage, eyelid surgeries can also affect corneal topography and refraction. Studies have found that patients with ptosis have topographic corneal aberrations from the eyelid exerting pressure on the cornea, while ptosis repair and blepharoplasty patients may undergo an astigmatic change postoperatively. Finally, the corneal flap created in laser-assisted in situ keratomileusis may be at risk for displacement or damage postoperatively with this risk changing, depending on method of flap creation, and time elapsed since keratorefractive surgery. SUMMARY: Eyelid and orbital conditions that predispose to dry eye syndrome and refractive changes should be evaluated and optimized prior to keratorefractive surgery. Patients electing to have oculoplastic surgery, like ptosis repair, should be fully healed prior to any refractive surgery to allow both refractive changes and eyelid positions to stabilize prior to the refractive surgery.


Assuntos
Blefaroptose/fisiopatologia , Síndromes do Olho Seco/fisiopatologia , Doenças Orbitárias/fisiopatologia , Erros de Refração/fisiopatologia , Procedimentos Cirúrgicos Refrativos , Astigmatismo/cirurgia , Blefaroptose/etiologia , Síndromes do Olho Seco/etiologia , Humanos , Ceratomileuse Assistida por Excimer Laser In Situ , Ceratoplastia Penetrante , Doenças Orbitárias/etiologia , Período Pós-Operatório , Refração Ocular/fisiologia
15.
16.
J Craniofac Surg ; 31(5): 1284-1286, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32516215

RESUMO

The purpose of this retrospective study was to evaluate the effectiveness of blepharoptosis surgery in patients with deepening of the upper eyelid sulcus (DUES). This case series included 10 consecutive patients (19 eyes) with DUES associated with use of a prostaglandin analog for glaucoma. Patients who had used bimatoprost and developed DUES were changed to an alternative prostaglandin analog and observed for ≥3 months. If there was no improvement, they underwent levator resection for blepharoptosis and were followed up for ≥6 months postoperatively. Improvement in margin reflex distance-1 and surgical complications was evaluated. After discontinuation of bimatoprost in 3 cases (6 eyes), mild subjective and objective improvement in DUES was seen in 2 cases (4 eyes) but without improvement in blepharoptosis. The prostaglandin analog used before surgery was travoprost in 4 eyes (21.0%), tafluprost in 7 eyes (36.9%; including 4 eyes switched from bimatoprost), and latanoprost in 8 eyes (42.1%; including 2 eyes switched from bimatoprost). The mean margin reflex distance-1 value was 1.11 ±â€Š0.96 mm before surgery and 3.72 ±â€Š0.81 mm at the final postoperative follow-up; the difference was significant (P = 3.32 × -10). There were no intraoperative or postoperative complications. Levator resection is a useful and safe procedure for blepharoptosis with DUES.


Assuntos
Blefaroptose/cirurgia , Idoso , Bimatoprost/uso terapêutico , Pálpebras , Feminino , Humanos , Latanoprosta/uso terapêutico , Masculino , Prostaglandinas F/uso terapêutico , Estudos Retrospectivos , Travoprost/uso terapêutico
17.
Medicine (Baltimore) ; 99(22): e20397, 2020 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-32481429

RESUMO

RATIONALE: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification along the anterolateral aspect of at least 4 contiguous vertebral bodies. A fracture involving the fused vertebra in patients with DISH often leads to severe instability and spinal cord injury. Spinal metastasis (Mets) and DISH can coexist in elderly patients and increase their risk of pathologic vertebral fractures. However, there are few reports on concomitant spinal Mets and DISH. PATIENT CONCERNS: A 78-year-old man who complained of gradual onset of paraparesis, sensory loss below the umbilicus, and incontinence (case 1) and a 63-year-old woman who complained of severe back pain and urinary incontinence (case 2). DIAGNOSIS: Two patients were diagnosed with spinal Mets and DISH. INTERVENTIONS: Decompression surgery was performed at the metastatic sites in case 1 whereas instrumentation surgery was performed in case 2 despite the fracture having a benign appearance with no associated neurologic symptoms. OUTCOMES: A vertebral fracture developed at the metastatic vertebra after decompression surgery in case 1. Severe instability of the surgical site in this case resulted in persistent paralysis even after subsequent revision surgery with instrumentation. In contrast, the clinical course was benign without any neurologic dysfunction at the 2-year follow-up in case 2. LESSONS: Instrumentation surgery should be performed in patients with DISH who develop spinal Mets even if there is no apparent instability.


Assuntos
Hiperostose Esquelética Difusa Idiopática/complicações , Neoplasias da Coluna Vertebral/secundário , Idoso , Blefaroptose , Neoplasias da Mama/patologia , Anormalidades Congênitas , Descompressão Cirúrgica/métodos , Feminino , Fixação Interna de Fraturas/métodos , Humanos , Hiperostose Esquelética Difusa Idiopática/cirurgia , Região Lombossacral/anormalidades , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/patologia , Fraturas da Coluna Vertebral/etiologia , Fraturas da Coluna Vertebral/cirurgia , Neoplasias da Coluna Vertebral/complicações , Neoplasias da Coluna Vertebral/cirurgia , Vértebras Torácicas/lesões , Vértebras Torácicas/cirurgia
19.
Pediatr. aten. prim ; 22(86): 165-168, abr.-jun. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-198531

RESUMO

El sarcoma granulocítico es una manifestación extramedular de la leucemia mieloide aguda (LMA) poco frecuente. Es más común en la población pediátrica y puede presentarse en cualquier momento en el curso de la enfermedad. En ocasiones, puede preceder a la aparición clínica de leucemia mieloide aguda. Se presenta el caso de un niño de tres años con infiltración orbitaria bilateral que precipitó el diagnóstico de LMA


Granulocytic sarcoma is an unusual extramedullary manifestation of acute myeloid leukemia (AML). It is more common in the pediatric population and it may present at any time in the course of the disease. Occasionally, it may precede the clinical onset of acute myeloid leukemia. The case of a 3-year-old male child with a bilateral orbital infiltration that precipitated the diagnosis of AML is presented


Assuntos
Humanos , Masculino , Pré-Escolar , Leucemia Mieloide Aguda/diagnóstico , Sarcoma Mieloide/diagnóstico , Neoplasias Orbitárias/diagnóstico , Blefaroptose/etiologia , Exoftalmia/etiologia , Citometria de Fluxo/métodos
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