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1.
Med. oral patol. oral cir. bucal (Internet) ; 25(5): e700-e705, sept. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-196527

RESUMO

BACKGROUND: Candidiasis is the most frequent mycotic infection of the oral cavity. The aim of this study was to investigate the presence of clinical oral candidiasis and Candida albicans yeast in a population diagnosed of primary Sjögren's syndrome (pSS) and to study the possible factors associated with this infection. MATERIAL AND METHODS: An observational cross-sectional study was conducted in 61 pSS patients (60 women, 1 man, mean age 57.64 ± 13.52) where patient based information (demographic and medical, tobacco and alcohol consumption history), intraoral parameters (presence of dentures, clinical signs of candidiasis), salivary analytical information (number of Candida albicans as colony-forming units per millilitre (CFU/mL), salivary pH levels, unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. RESULTS: 13.1% of pSS patients presented oral signs of candidiasis. Denture stomatitis and angular cheilitis were the most common lesions. 87.5% of patients with clinical candidiasis presented reduced pH levels and salivary flow in both UWS and SWS. A significant statistical negative correlation was found between CFU/mL of Candida albicans and levels of UWS and SWS. A negative correlation was found between pH levels and CFU/mL, although not statistically significant. CONCLUSIONS: A reduced salivary flow may predispose pSS patients to Candida albicans overgrowth, which may show with clinical signs. Preventive measures are of great importance to avoid and to treat this condition promptly


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Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Síndrome de Sjogren/complicações , Síndrome de Sjogren/microbiologia , Candidíase Bucal/etiologia , Candida albicans/isolamento & purificação , Estudos Transversais , Fatores de Risco , Contagem de Colônia Microbiana , Estatísticas não Paramétricas , Xerostomia/complicações , Saliva/microbiologia
2.
J Cancer Res Ther ; 16(3): 470-477, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32719253

RESUMO

Objective: The aim of the study is to assess the effect of probiotic bacteria on oral Candida counts in cancer patients who are undergoing head- and neck-radiotherapy in a tertiary care center. Study Design: The study was a randomized clinical trial including 90 patients who just completed head- and neck-radiotherapy. Materials and Methods: Participants were randomly allocated into three equal sized groups, i.e., probiotics group, candid group, and combination groups. Oral rinse samples of the patients were collected before and after the intervention for the identification of Candida. The samples were incubated on Sabouraud's Dextrose Agar with Chloramphenicol at 37°C for 48 h, to assess the counts of colony-forming units/milliliter (CFU/ml) of Candida in saliva, and further on chrome agar plates to identify the Candida spp. Data were analyzed using mixed ANOVA to compare mean CFU/ml of Candida among three groups before and after the intervention. Results: A total of 86 patients were included in the final analysis and there was a statistically significant reduction in mean Candida spp. Counts (CFU/ml) after intervention in all the three groups (P = 0.000) and significant reductions identified in both probiotic and combination therapy groups. Apart from reduction in Candida albicans, significant decrease in Candida glabrata and Candida tropicalis was observed after probiotics usage compared to other groups. Conclusions: The present study suggests that probiotic bacteria were effective in reducing oral Candida spp which can be recommended alone or in combination with traditional antifungal agents for effective reduction in oral Candida in head- and neck-radiotherapy patients.


Assuntos
Candida albicans/efeitos dos fármacos , Candidíase Bucal/tratamento farmacológico , Neoplasias de Cabeça e Pescoço/radioterapia , Probióticos/uso terapêutico , Radioterapia/efeitos adversos , Saliva/microbiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Candidíase Bucal/etiologia , Candidíase Bucal/patologia , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Saliva/efeitos dos fármacos , Saliva/efeitos da radiação , Resultado do Tratamento , Adulto Jovem
3.
Support Care Cancer ; 28(3): 1069-1075, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31177394

RESUMO

PURPOSE: The present retrospective multicenter study intended to investigate the factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas. METHODS: A total of 326 patients who underwent radiotherapy for oral and oropharyngeal cancers were enrolled in the study. The patients' age, sex, body mass index, primary site, diabetes, serum albumin, creatinine, hemoglobin, leukocyte and lymphocyte, concurrent cisplatin or cetuximab, method of radiation, total radiation dose, feeding route, use of spacers, pilocarpine hydrochloride, and corticosteroid ointment were examined, and the associations of each variable with oral mucositis and candidiasis were analyzed by multivariate Cox regression analysis. RESULTS: Grade 3 oral mucositis occurred in 136 (41.7%) patients. Male sex, oropharyngeal cancer, low hemoglobin levels, low leukocytes or lymphocytes, concurrent cisplatin or cetuximab, and oral feeding were found to be significantly associated with a higher incidence of severe oral mucositis. Oral candidiasis occurred in 101 (31.0%) patients. Oropharyngeal cancer, low leukocyte count, and oral mucositis of grade 2 or higher were found to be significantly associated with a higher incidence of oral candidiasis. The use of a topical steroid ointment was not found to be a risk factor for oral candidiasis. CONCLUSIONS: The present retrospective study demonstrated that certain factors may predispose patients with oral and oropharyngeal cancers receiving radiotherapy to develop severe oral mucositis and oral candidiasis. A preventive strategy for severe oral mucositis needs to be established in the future for high-risk cases.


Assuntos
Candidíase Bucal/etiologia , Neoplasias Bucais/radioterapia , Neoplasias Orofaríngeas/radioterapia , Estomatite/etiologia , Administração Tópica , Adulto , Idoso , Cetuximab/administração & dosagem , Cetuximab/efeitos adversos , Cisplatino/administração & dosagem , Cisplatino/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/microbiologia , Neoplasias Orofaríngeas/microbiologia , Lesões por Radiação/etiologia , Lesões por Radiação/microbiologia , Estudos Retrospectivos , Esteroides/administração & dosagem , Esteroides/efeitos adversos
4.
Nutrients ; 11(10)2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31615039

RESUMO

Oral candidiasis (OC) is an increasing health problem due to the introduction of new drugs, population aging, and increasing prevalence of chronic illness. This study systematically reviews the effects of the oral intake of probiotics, prebiotics, and synbiotics on Candida spp. counts (colony-forming units (CFU)/mL) in oral and palatal samples. A literature search was conducted. Twelve studies, eight randomized clinical trials (RCTs), and four pre-post studies, resulted as eligible for the meta-analysis, which was performed through a Bayesian random-effects model. All studies analyzed probiotics, and none of them analyzed prebiotics or synbiotics. The treatments effects were measured in terms of odds ratio (OR) of OC (CFU/mL >102, 103, or 104). The meta-analytic OR was 0.71 (95% credibility interval (CrI): 0.37, 1.32), indicating a beneficial effect of treatment; the I2 index was 56.3%. Focusing only on RCTs, the OR was larger and more precise at 0.53 (95% CrI: 0.27, 0.93). The effect of treatment appeared to be larger on denture wearers. Our findings indicate that the intake of probiotics can have a beneficial effect on OC and that the effects could vary according to the patients' characteristics. Due to the presence of medium-high-risk studies, the results should be interpreted with caution.


Assuntos
Candidíase Bucal/tratamento farmacológico , Probióticos , Antifúngicos/uso terapêutico , Candidíase Bucal/etiologia , Humanos , Fatores de Risco
6.
BMC Infect Dis ; 19(1): 664, 2019 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-31349802

RESUMO

BACKGROUND: Several studies have identified predictors of severe infections in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the development of oral candidiasis (OC) as a predictor of subsequent severe infections has not been evaluated. The aim of this study was to assess the association between OC and subsequent severe infection requiring hospitalization during immunosuppressive therapy in AAV. METHODS: This single-center retrospective cohort study included 71 consecutive patients with newly diagnosed AAV from Aichi Medical University Hospital, Japan, starting immunosuppressive therapy between March 2013 and December 2018. The relationships between OC and subsequent severe infections were assessed using multivariate Cox proportional hazards models, adjusted for clinically relevant factors. RESULTS: During the follow-up period (median, 23 months; interquartile range, 11-51 months), 25 severe infectious episodes occurred in 19 patients (26.8%) and OC occurred in 17 patients (23.9%). A log-rank test showed that the OC group was significantly associated with severe infection (P <  0.001). Multivariate Cox proportional hazards models identified lower serum albumin (per 1 g/dl adjusted hazard ratio (HR)  = 0.38, 95% confidence interval (CI): 0.15-0.85; P  =  0.018), use of methylprednisolone pulse (adjusted HR  =  5.44, 95% CI: 1.54-20.0; P  =  0.010), and OC (adjusted HR  = 5.31, 95% CI: 1.86-15.8; P  =  0.002) as significant predictors of severe infection. Furthermore, a significant effect modification of the use of methylprednisolone pulse on OC was observed (P <  0.001). CONCLUSIONS: OC is one of the predictors of subsequent severe infections. The results suggest the importance of prolonging infection surveillance, especially for patients who developed OC under strong immunosuppressive therapy.


Assuntos
Candidíase Bucal/etiologia , Imunossupressores/efeitos adversos , Idoso , Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/tratamento farmacológico , Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/imunologia , Feminino , Seguimentos , Humanos , Imunossupressão , Imunossupressores/administração & dosagem , Japão , Masculino , Modelos de Riscos Proporcionais , Estudos Retrospectivos
7.
PLoS Pathog ; 15(4): e1007717, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-31009520

RESUMO

Infectious complications are a common cause of morbidity and mortality in cancer patients undergoing chemotherapy due to increased risk of oral and gastrointestinal candidiasis, candidemia and septicemia. Interactions between C. albicans and endogenous mucosal bacteria are important in understanding the mechanisms of invasive infection. We published a mouse intravenous chemotherapy model that recapitulates oral and intestinal mucositis, and myelosuppression in patients receiving 5-fluorouracil. We used this model to study the influence of C. albicans on the mucosal bacterial microbiome and compared global community changes in the oral and intestinal mucosa of the same mice. We validated 16S rRNA gene sequencing data by qPCR, in situ hybridization and culture approaches. Mice receiving both 5Fu and C. albicans had an endogenous bacterial overgrowth on the oral but not the small intestinal mucosa. C. albicans infection was associated with loss of mucosal bacterial diversity in both sites with indigenous Stenotrophomonas, Alphaproteobacteria and Enterococcus species dominating the small intestinal, and Enterococcus species dominating the oral mucosa. Both immunosuppression and Candida infection contributed to changes in the oral microbiota. Enterococci isolated from mice with oropharyngeal candidiasis were implicated in degrading the epithelial junction protein E-cadherin and increasing the permeability of the oral epithelial barrier in vitro. Importantly, depletion of these organisms with antibiotics in vivo attenuated oral mucosal E-cadherin degradation and C. albicans invasion without affecting fungal burdens, indicating that bacterial community changes represent overt dysbiosis. Our studies demonstrate a complex interaction between C. albicans, the resident mucosal bacterial microbiota and the host environment in pathogenesis. We shed significant new light on the role of C. albicans in shaping resident bacterial communities and driving mucosal dysbiosis.


Assuntos
Candida albicans/patogenicidade , Candidíase Bucal/etiologia , Disbiose/induzido quimicamente , Fluoruracila/efeitos adversos , Mucosa Intestinal/microbiologia , Mucosa Bucal/microbiologia , Animais , Antimetabólitos/efeitos adversos , Candida albicans/efeitos dos fármacos , Candida albicans/genética , Candidíase Bucal/patologia , Modelos Animais de Doenças , Feminino , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/patologia , Camundongos , Camundongos Endogâmicos C57BL , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/patologia
8.
Biomed Pharmacother ; 113: 108597, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30851547

RESUMO

Cigarette smoke (CS) exposure and Candida albicans (C. albicans) infection are epidemiological risk factors for oral diseases, such as oral leukoplakia (OLK). Smoking-induced inflammation and immune modulation are potentially important mechanisms in the development of diseases, although the biological mechanism of how CS exposure impacts host defenses has not been elucidated. The critical components of host defense, NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and IL-1ß, are required for normal immune function in order to efficiently control infection. This paper studies the molecular mechanism of the immune-suppressive effect of CS on the oral mucosa of animal models. Rats were exposed to intraoral CS to simulate active human smoking and/or to C. albicans for 3 months or 6 months, and their ability to control the infection of C. albicans was examined. The CS and C. albicans co-exposed rats showed early stage lesions of OLK and were more susceptible to C. albicans than those in the C. albicans-exposed group. CS caused a reduced expression of the NLRP3 inflammasome and diminished the secretion of IL-1ß and IL-18 maturing by the NLRP3 inflammasome, which were stimulated by C. albicans. CS and immune suppression appear to be closely interwoven at multiple levels. This is the first animal model of active smoking through the mouth, and these data demonstrate that CS suppresses the protective immune response to C. albicans in rats through the NLRP3 inflammasome.


Assuntos
Candida albicans/patogenicidade , Candidíase Bucal/etiologia , Interações entre Hospedeiro e Microrganismos/imunologia , Inflamassomos/metabolismo , Mucosa Bucal/imunologia , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Fumar/efeitos adversos , Animais , Candidíase Bucal/imunologia , Citocinas/metabolismo , Modelos Animais de Doenças , Imunidade Inata , Mucosa Bucal/microbiologia , Ratos Wistar , Saliva/imunologia , Fumar/imunologia
9.
J Leukoc Biol ; 106(1): 193-200, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-30776147

RESUMO

The oral cavity is a unique environment containing teeth juxtaposed with soft tissues, all of which are constantly bathed in microbial products and host-derived factors. While microbial dysbiosis in the oral cavity clearly leads to oral inflammatory disease, recent advances find that endogenous danger-associated molecular patterns (DAMPs) released from oral and salivary tissue also contribute to the progression of inflammatory and autoimmune disease, respectively. In contrast, DAMPs produced during oral fungal infection actually promote the resolution of infection. Here, we present a review of the literature suggesting a role for signaling by DAMPs, which may intersect with pathogen-associated molecular pattern (PAMP) signaling, in diseases that manifest in the oral cavity, specifically periodontal disease, oropharyngeal candidiasis, and Sjögren's syndrome.


Assuntos
Alarminas/fisiologia , Candidíase Bucal/etiologia , Doenças Periodontais/etiologia , Síndrome de Sjogren/etiologia , Candidíase Bucal/imunologia , Armadilhas Extracelulares/fisiologia , Humanos , Padrões Moleculares Associados a Patógenos/farmacologia , Doenças Periodontais/imunologia , Transdução de Sinais/fisiologia , Síndrome de Sjogren/imunologia
10.
NPJ Prim Care Respir Med ; 29(1): 3, 2019 02 08.
Artigo em Inglês | MEDLINE | ID: mdl-30737400

RESUMO

Co-prescription of Aerochamber® spacer with non-extrafine beclometasone diproprionate (non-EF BDP) is common but unlicensed. We report a comparison of inhaled corticosteroid (ICS)-related adverse events between patients co-prescribed Aerochamber compared to the licensed Volumatic® spacer. We utilised two historical cohorts: questionnaire-based and electronic medical record (EMR)-based, to assess patient-reported and EMR-recorded adverse events in patients with asthma prescribed non-EF BDP. Marginal effect estimate (MEE) was calculated to determine non-inferiority of Aerochamber compared to Volumatic in terms of patient-reported oral thrush and hoarseness with margin of 0.13. Other patient-reported adverse events (sore throat, bruising, weight gain, and coughing), and EMR-recorded adverse events were also assessed. Rate of patient-reported oral adverse events were non-inferior in 385 patients prescribed Aerochamber compared to 155 patients prescribed Volumatic (27.7 vs 29.9%; MEE, -0.043; 95% CI, -0.133 to 0.047). Total patient-reported adverse events did not differ significantly between Aerochamber and Volumatic (53.3 vs 49.7% with ≥1 adverse event). The EMR-based study of 1471 matched pairs of subjects did not show significantly different number of EMR-recorded adverse events between Aerochamber and Volumatic (12.5 vs 12.8% with ≥1 adverse events). Co-prescribing Aerochamber with non-EF BDP does not increase the risk for patient-reported and EMR-recorded ICS-related adverse events compared to co-prescribing Volumatic.


Assuntos
Antiasmáticos/efeitos adversos , Asma/tratamento farmacológico , Beclometasona/efeitos adversos , Espaçadores de Inalação/efeitos adversos , Administração por Inalação , Adulto , Antiasmáticos/administração & dosagem , Antiasmáticos/uso terapêutico , Beclometasona/administração & dosagem , Beclometasona/uso terapêutico , Candidíase Bucal/etiologia , Feminino , Rouquidão/etiologia , Humanos , Masculino , Inaladores Dosimetrados/efeitos adversos , Pessoa de Meia-Idade
11.
Turk J Pediatr ; 61(2): 174-179, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31951326

RESUMO

Dogruel D, Gündeslioglu ÖÖ, Yilmaz M, Alabaz D, Altintas DU, Kocabas E. Clinical findings and genetic analysis of the patients with IL- 12Rß1 deficiency from southeast Turkey. Turk J Pediatr 2019; 61: 174-179. IL-12Rß1 deficiency is an autosomal recessive disorder characterized by predisposition to poorly pathogenic mycobacteria, salmonella and candida species. We aimed to analyze the clinical manifestations, immunological and genetic features of IL-12Rß1 deficiency in 10 Turkish patients from a single center. We retrospectively studied the clinical manifestations and genetic analysis of the IL-12Rß1 deficiency patients from 2008 to 2016. Ten patients were diagnosed and followed for eight years. The mean age at onset and diagnosis were 24.1±42.5 (med:10.5) and 52.3±6.83 (med:20) months, respectively. Parental consanguinity rate was 81.8%. All patients were BCG vaccinated. Abscess and axillary lymphadenopathy in the vaccinated area was the most common initial presentation following the BCG vaccination, six patients had recurring oral candidiasis. Active infections were treated appropriately, in addition to prophylactic therapy with IFNÉ£. We identified 6 different mutations in the IL12RB1 gene in 10 patients including 5 splice-site mutations, 3 missense, 1 frameshift, 1 premature stop codon. One of these mutations was novel. The most common mutation was IVS8+1G > A(c.783+1G > A) followed by p.R175W(c.523C > T). This study emphasizes that patients presented with abscess and axillary lymphadenopathy associated with BCG vaccination should be evaluated for IL-12Rß1 deficiency.


Assuntos
Predisposição Genética para Doença , Infecções por Mycobacterium/genética , Receptores de Interleucina-12/deficiência , Receptores de Interleucina-12/genética , Adolescente , Vacina BCG/efeitos adversos , Candidíase Bucal/etiologia , Criança , Pré-Escolar , Consanguinidade , Feminino , Seguimentos , Humanos , Lactente , Linfadenopatia/etiologia , Masculino , Mutação , Recidiva , Estudos Retrospectivos , Turquia
12.
Microb Pathog ; 126: 363-367, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30471434

RESUMO

BACKGROUND: There is no data available on the prevalence of oral mucosal lesion and candida infection among DM patients which necessitate conducting a local or nation-wide study to assess the oral mucosa lesions and candida prevalent in diabetic patients in Riyadh, Saudi Arabia. OBJECTIVES: The objective of the present study was to characterize oral mucosa lesions, and the prevalence of yeasts in diabetic patients and their association with the risk factors in comparison with a group of non-diabetic controls. METHODS: Study design: A cross-sectional comparative study was conducted assuming 50% of the diabetic patients have oral lesions compared to nondiabetic patients and a power of 80% with 5% level of significance, the minimum required sample size was estimated to be 115 in each group. The buccal swabs were collected to isolate Candida species from the individual patient with a current and former history of diabetes. The laboratory findings were collected and the clinical examination of the oral mucosa was processed at the department of microbiology. RESULTS: The results inferred a significant presence of oral mucosa alterations in the diabetic group. A majority of the patients were suffering from type 2 diabetes for the past 10 years. C. albicans was the predominant yeast, followed by. C. tropicalis and C. krusei nonalbicans species that were most frequently isolated. Diabetes and smoking habit were the two risk factors for oral mucosa alterations. CONCLUSIONS: The study found a significant presence of oral mucosa alterations in the diabetic group and the fungal infection tended to be more in the diabetic group with a high incidence of C. albicans. The presence of diabetes and smoking habit were two risk factors identified as significant for oral mucosa alterations. The significant variation in education level in groups indicates that education would help to enhance the prognosis in diabetic patients and healthcare behavior.


Assuntos
Candidíase Bucal/epidemiologia , Candidíase Bucal/etiologia , Candidíase Bucal/microbiologia , Diabetes Mellitus Tipo 2/complicações , Mucosa Bucal/microbiologia , Leveduras/isolamento & purificação , Leveduras/patogenicidade , Candida/classificação , Candida/isolamento & purificação , Candida albicans/isolamento & purificação , Candida tropicalis/isolamento & purificação , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Arábia Saudita/epidemiologia , Fumar/efeitos adversos , Leveduras/classificação
13.
Medicine (Baltimore) ; 97(44): e13073, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30383690

RESUMO

The aims of this study were to investigate the incidence and risk factors for oral candidiasis in patients receiving radiotherapy for head and neck cancer, and to determine the influence of topical steroid therapy on the development of oral candidiasis.We conducted a retrospective study of 300 patients receiving radiotherapy to the head and neck region. The primary endpoint was the incidence of oral candidiasis during radiotherapy. Associations between the incidence of oral candidiasis and various clinical factors were investigated. The cumulative incidence rate of oral candidiasis was calculated using the Kaplan-Meier method and analyzed by the log-rank test and Cox regression. Propensity score-matched analysis was used to assess the influence of topical steroid therapy on the development of oral candidiasis.Oral candidiasis occurred in 75 (25.0%) of the 300 patients. Multivariate analysis identified minimum lymphocyte count and severity of oral mucositis during radiotherapy as independent risk factors for the development of oral candidiasis. Topical steroid therapy for oral mucositis was not associated with the incidence of oral candidiasis according to multivariate and propensity score matching analyses.Oral candidiasis was associated with the suppression of the host's immunity and severe oral mucositis, but not topical steroid therapy. Proper oral health care during radiotherapy and the prevention of severe oral mucositis may reduce the incidence of oral candidiasis.


Assuntos
Candidíase Bucal/epidemiologia , Candidíase Bucal/etiologia , Neoplasias de Cabeça e Pescoço/radioterapia , Radioterapia/efeitos adversos , Esteroides/administração & dosagem , Administração Tópica , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Pontuação de Propensão , Estudos Retrospectivos , Fatores de Risco , Esteroides/efeitos adversos
14.
J. oral res. (Impresa) ; 7(8): 391-394, nov. 30, 2018. ilus
Artigo em Inglês | LILACS | ID: biblio-1121123

RESUMO

Pseudomembranous candidiasis is the most frequent type of infection by candida spp., and candida albicans is the most common species to cause it. candidiasis can be due to other candida species less frequently, as is the case of candida tropicalis a pathogenic species that can cause infection in immunocompromised patients. the aim of this case report is to describe a pathological condition produce by candida tropicalis.


Assuntos
Humanos , Masculino , Adulto , Candidíase , Candidíase Bucal/etiologia , Candida tropicalis , Candida albicans , HIV
15.
Braz Oral Res ; 32: e92, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30231172

RESUMO

Despite the large number of published studies about oral candidiasis and associated risk factors, reports of large single-center retrospective studies on the prevalence of oral candidiasis, risk factors, and the oral candidiasis types diagnosed more frequently in oral diagnostic reference centers are scarce. The objective of the present study was to retrospectively survey the demographic and clinical profiles of 1,534 patients diagnosed with candidiasis and treated at the Center for Diagnosis of Oral Diseases (CDOD), Pelotas Dental School, Federal University of Pelotas between 1997 and 2014. Using a retrospective, cross-sectional, epidemiological design, data on race, gender, age, systemic diseases, oral candidiasis type and location, symptoms, and harmful habits such as smoking and alcohol consumption were collected. The statistical analysis was performed using STATA version 13.1. Risk factors for chronic atrophic candidiasis (CAC) were evaluated using Poisson regression with robust variance (p ≤ 0.05). The majority of patients with oral candidiasis seen at the CDOD over the 18-year period of analysis were Caucasian women, aged 51-60 years, nonsmokers, and nondrinkers, with no systemic disease, and who wore some form of dental prostheses. CAC was the single most common clinical type of candidiasis detected, and the most frequently affected oral site was the palate. These data from a large single-center in Brazil agree with previous evidence about the clinical and demographic profiles of patients with oral candidiasis.


Assuntos
Candidíase Bucal/epidemiologia , Candidíase Bucal/etiologia , Distribuição por Idade , Idoso , Brasil/epidemiologia , Candidíase Bucal/patologia , Doença Crônica , Estudos Transversais , Prótese Dentária/efeitos adversos , Feminino , Humanos , Masculino , Registros Médicos/estatística & dados numéricos , Pessoa de Meia-Idade , Distribuição de Poisson , Prevalência , Estudos Retrospectivos , Fatores de Risco , Distribuição por Sexo
16.
PLoS Pathog ; 14(9): e1007316, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30252918

RESUMO

Candida albicans is an opportunistic fungal pathogen that can infect oral mucosal surfaces while being under continuous flow from saliva. Under specific conditions, C. albicans will form microcolonies that more closely resemble the biofilms formed in vivo than standard in vitro biofilm models. However, very little is known about these microcolonies, particularly genomic differences between these specialized biofilm structures and the traditional in vitro biofilms. In this study, we used a novel flow system, in which C. albicans spontaneously forms microcolonies, to further characterize the architecture of fungal microcolonies and their genomics compared to non-microcolony conditions. Fungal microcolonies arose from radially branching filamentous hyphae that increasingly intertwined with one another to form extremely dense biofilms, and closely resembled the architecture of in vivo oropharyngeal candidiasis. We identified 20 core microcolony genes that were differentially regulated in flow-induced microcolonies using RNA-seq. These genes included HWP1, ECE1, IHD1, PLB1, HYR1, PGA10, and SAP5. A predictive algorithm was utilized to identify ten transcriptional regulators potentially involved in microcolony formation. Of these transcription factors, we found that Rob1, Ndt80, Sfl1 and Sfl2, played a key role in microcolony formation under both flow and static conditions and to epithelial surfaces. Expression of core microcolony genes were highly up-regulated in Δsfl1 cells and down-regulated in both Δsfl2 and Δrob1 strains. Microcolonies formed on oral epithelium using C. albicans Δsfl1, Δsfl2 and Δrob1 deletion strains all had altered adhesion, invasion and cytotoxicity. Furthermore, epithelial cells infected with deletion mutants had reduced (SFL2, NDT80, and ROB1) or enhanced (SFL2) immune responses, evidenced by phosphorylation of MKP1 and c-Fos activation, key signal transducers in the hyphal invasion response. This profile of microcolony transcriptional regulators more closely reflects Sfl1 and Sfl2 hyphal regulatory networks than static biofilm regulatory networks, suggesting that microcolonies are a specialized pathogenic form of biofilm.


Assuntos
Candida albicans/genética , Candida albicans/patogenicidade , Biofilmes/crescimento & desenvolvimento , Candida albicans/crescimento & desenvolvimento , Candidíase Bucal/etiologia , Candidíase Bucal/microbiologia , Linhagem Celular , Contagem de Colônia Microbiana , Proteínas Fúngicas/genética , Redes Reguladoras de Genes , Genoma Fúngico , Humanos , Hifas/genética , Hifas/crescimento & desenvolvimento , Hifas/patogenicidade , Mutação , Infecções Oportunistas/etiologia , Infecções Oportunistas/microbiologia , Fatores de Transcrição/genética , Virulência/genética
17.
J Investig Clin Dent ; 9(4): e12351, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30019446

RESUMO

The purpose of the present study paper was to review the reported prevalence of the oral manifestations of HIV (OM-HIV) worldwide since 1980, and to determine the global variation in its prevalence over time. PubMed, Scopus, Embase and Google Scholar were searched. The filter "English" was used. The timeframe searched was 1980- 2015. The PRISMA flow chart was used. Data were extracted using the Joanna Briggs Institute standardized data extraction form and transferred to SPSS version 22 for analysis. The systematic review of 97 studies (70 low bias risk) showed that the prevalence of OM-HIV continue to be significant in developing countries. Globally and through all the decades, oral candidiasis remained the most commonly encountered OM-HIV, including among patients on antiretroviral therapy (ART) (26.2%). Hairy leukoplakia was more prevalent in Europe and America compared with Africa and Asia. Oral warts were reported more often in studies on patients receiving ART. Interestingly, salivary gland disease decreased in the developed world and increased in developing countries over time. Despite the changing pattern of these conditions over time, there is no evidence that the OM-HIV have become of less significance globally. Maintaining the drive for high-quality research in the subject will have an impact on less developed countries to help address oral health inequalities.


Assuntos
Infecções por HIV/complicações , Doenças da Boca/etiologia , Fármacos Anti-HIV/uso terapêutico , Candidíase Bucal/etiologia , Infecções por HIV/tratamento farmacológico , Infecções por HIV/patologia , Humanos , Leucoplasia Pilosa/etiologia , Boca/patologia , Doenças da Boca/patologia
18.
J Pak Med Assoc ; 68(3): 437-443, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29540881

RESUMO

Numerous substances may have an adverse influence on the oral region by virtue of their potentially harmful effects. Dental practitioners are often the first to see these effects in the head and neck region. Knowledge of the damaging consequences of agents such as alcohol, tobacco, areca nut, medications, alcohol-containing mouthwashes, dental devices and materials can assist the practitioners in clinical decision-making and accurate diagnosis of associated lesions. More importantly, timely diagnosis and prompt reporting of such harmful effects improve the quality of care. Such knowledge may also help in patient's education for the avoidance of associated adverse effects (AEs). Consequently, a thorough acquaintance of AEs will consolidate the distinct role of medical and oral health practitioners in safeguarding the patients' oral and systemic well-being. This article was planned to review the harmful consequences of specific substances on the oral health. Traditionally, the emphasis of review articles has been on reviewing the harmful effects of a single entity on oral health. This review is unique in the sense that it comprehensively and collectively focussed on the harmful effects on the oral health of addictive and illicit substances (alcohol, betel nut), medications, alcohol-containing mouthwashes, medications and dental materials.


Assuntos
Consumo de Bebidas Alcoólicas/efeitos adversos , Areca/efeitos adversos , Materiais Dentários/efeitos adversos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Doenças da Boca/etiologia , Antissépticos Bucais/efeitos adversos , Uso de Tabaco/efeitos adversos , Candidíase Bucal/etiologia , Fibrose/etiologia , Crescimento Excessivo da Gengiva/etiologia , Humanos , Ceratose/etiologia , Leucoplasia Oral/etiologia , Mucosa Bucal , Úlceras Orais/etiologia , Distúrbios do Paladar/etiologia
19.
Ned Tijdschr Tandheelkd ; 125(2): 81-86, 2018 Feb.
Artigo em Holandês | MEDLINE | ID: mdl-29461540

RESUMO

Juvenile idiopathic arthritis (JIA) is the most common cause of chronic inflammation of the joints in childhood. Currently, JIA is divided into 7 subtypes, distinguished on the basis of the symptoms present in the first six months of the illness. Pharmacological treatment is different for every subtype. With all forms of JIA, dental problems can occur. These can include an increasing incidence of dental caries, stomatitis with the use of methotrexate, oral candidiasis with the use of immunosuppressive medication and temporal mandibular joint (TMJ) arthritis. The detection of TMJ arthritis seems to be especially difficult in daily practice. Dentists could play a role in identifying the TMJ complication in children with JIA.


Assuntos
Artrite Juvenil/complicações , Cárie Dentária/etiologia , Imunossupressores/efeitos adversos , Transtornos da Articulação Temporomandibular/etiologia , Adolescente , Artrite Juvenil/tratamento farmacológico , Candidíase Bucal/epidemiologia , Candidíase Bucal/etiologia , Criança , Pré-Escolar , Cárie Dentária/epidemiologia , Feminino , Humanos , Masculino , Transtornos da Articulação Temporomandibular/epidemiologia
20.
Ciênc. Saúde Colet ; 23(1): 115-122, Jan. 2018. tab
Artigo em Português | LILACS | ID: biblio-890487

RESUMO

Resumo Esta revisão integrativa da literatura tem por objetivo identificar as principais lesões bucais que afetam pacientes pediátricos com HIV, bem como descrever o efeito da terapia antirretroviral altamente ativa (HAART) sobre essas lesões, comparando-a com a terapia antirretroviral (ART). Foi feita uma busca nas bases de dados PubMed e Scielo, seguindo critérios de inclusão e exclusão pré-determinados. Foram selecionados dezenove artigos científicos e extraídas as informações principais sobre prevalência e a frequência das manifestações bucais em pacientes pediátricos HIV positivos e o efeito da terapêutica aplicada. As lesões mais frequentes foram candidíase oral, gengivite, aumento das parótidas e eritema gengival linear. O uso da HAART mostrou diminuir a prevalência das manifestações bucais nos pacientes pediátricos com HIV e ser mais eficaz que a ART. Os achados deste estudo sugerem que a manifestação bucal mais frequente em pacientes pediátricos com HIV é a candidíase oral, seguida de alterações como gengivite e aumento das glândulas parótidas. O uso de HAART parece reduzir a prevalência dessas lesões orais, apresentando resultados mais eficazes que os da ART.


Abstract This integrative literature review aims to identify the main oral lesions affecting pediatric patients with HIV, and describe the effect of highly active antiretroviral therapy (HAART) on these injuries, comparing it to antiretroviral therapy (ART). A search was conducted in PubMed and Scielo databases, following predetermined inclusion and exclusion criteria. 19 papers were selected and the main information on the prevalence and frequency of oral manifestations in HIV-positive pediatric patients and effect of therapy applied were extracted. The most frequent injuries were oral candidiasis, gingivitis, parotid gland enlargement and linear gingival erythema. The use of HAART shown to reduce the prevalence of oral manifestations in pediatric patients with HIV and be more effective than ART. The findings of this study suggest that the most frequent oral manifestation in HIV-infected children is oral candidiasis, followed by changes such as gingivitis and enlargement parotid glands. The use of HAART appears to reduce the prevalence of these oral lesions, showing more effective results than ART.


Assuntos
Humanos , Criança , Infecções por HIV/complicações , Fármacos Anti-HIV/administração & dosagem , Doenças da Boca/etiologia , Glândula Parótida/patologia , Candidíase Bucal/etiologia , Candidíase Bucal/prevenção & controle , Candidíase Bucal/epidemiologia , Infecções por HIV/tratamento farmacológico , Infecções por HIV/epidemiologia , Prevalência , Infecções Oportunistas Relacionadas com a AIDS/prevenção & controle , Infecções Oportunistas Relacionadas com a AIDS/epidemiologia , Terapia Antirretroviral de Alta Atividade/métodos , Gengivite/etiologia , Gengivite/prevenção & controle , Gengivite/epidemiologia , Doenças da Boca/prevenção & controle
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