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1.
Zhonghua Bing Li Xue Za Zhi ; 48(1): 26-30, 2019 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-30641642

RESUMO

Objective: To investigate MAML2 gene-translocation in primary pulmonary mucoepidermoid carcinoma (PMEC) and pulmanary adenosquamous carcinoma, and the optimal diagnostic immunohistiochemical (IHC) panel in distinguishing PMEC from adenosqumous carcinoma. Methods: Twenty-four cases of PMEC and 44 adenosqumous carcinoma diagnosed in the Guangdong General Hospital were tested for MAML2 translocation by fluorescent in-situ hybridization (FISH) using tissue array. An IHC panel including TTF1, Napsin A, CK5/6, p63, p40 and Ki-67 was performed on the cohort. The clinical data for all cases were collected and all PMEC patients had follow-up information. Results: The patients' age ranged form 6 to 73 years, with a median age of 32 years. The male to female ratio was 1.4∶1.0. MAML2 translocation was found in 16/24 (66.7%) cases of PMEC whereas all 44 cases adenosqumous carcinoma were negative for translocation. All the cases of the PMEC were negative for TTF1 and Napsin A but positive for CK5/6, p63 and p40 in the intermediate cells and epidermal-like cells. In most PMEC cases, the Ki-67 expression index was lower than 10%. In contrast, most cases of adenosqumous carcinomas expressed TTF1 and Napsin A in the adenomatous component and CK5/6, p63 and p40 in the squamous component, which expression pattern was different from that of PMEC. Based on IHC staining, 2 cases of highly invasive ALK-positive adenocarcinoma mimicing PMEC were also found in the study. Conclusions: MAML2 gene translocation can be detected in about two-third of PMEC. Translocation of MAML2 gene and lower morphology grading are associated with good prognosis. The combined use of IHC antibodies panel is helpful to distinguish PMEC from the adenosqumous carcinoma and adenocarcinoma mimicing PMEC.


Assuntos
Carcinoma Adenoescamoso/genética , Carcinoma Mucoepidermoide/genética , Proteínas de Ligação a DNA/genética , Neoplasias Pulmonares/genética , Proteínas Nucleares/genética , Fatores de Transcrição/genética , Adolescente , Adulto , Idoso , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/patologia , Carcinoma Mucoepidermoide/química , Carcinoma Mucoepidermoide/patologia , Criança , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias Pulmonares/química , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Translocação Genética , Adulto Jovem
2.
Am J Surg Pathol ; 42(11): 1419-1428, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30138216

RESUMO

"Mucoepidermoid carcinoma (MEC)" has been accepted as a synonym for pancreatic adenosquamous carcinoma (ASC). Pancreatic ASC can show salivary gland-type MEC-like morphology. CRTC1/3-MAML2 fusion gene is a characteristic molecular feature of MEC of the salivary gland. We conducted this study to clarify whether the pancreatic ASC with salivary gland-type MEC-like morphology (Pan-MEC) is a pancreatic counterpart of salivary gland-type MEC (Sal-MEC). We retrospectively analyzed 37 pancreatic ASCs including 16 Pan-MECs and 21 tumors without MEC-like features (ASC-NOS [not otherwise specified]), and we investigated (1) clinicopathologic features, (2) the presence of CRTC1/3-MAML2 fusion gene by reverse transcription polymerase chain reaction, (3) the presence of rearrangement of MAML2 gene by fluorescence in situ hybridization, and (4) mucin core proteins by immunohistochemistry. We also compared 16 Pan-MECs with 20 Sal-MECs by immunohistochemistry for mucin core protein. There were no significant differences of any clinicopathologic characteristics and survival analysis between the Pan-MECs and ASCs-NOS. Of note, the pancreatic ASCs (including Pan-MEC and ASC-NOS) were significantly more aggressive than conventional pancreatic ductal adenocarcinoma. In addition, all Pan-MECs were histologically high-grade. CRTC1/3-MAML2 fusion gene and MAML2 gene rearrangement were not detected in any ASCs including Pan-MECs. There were significant differences of MUC5AC and MUC6 between the Pan-MECs and Sal-MECs, but no significant differences of mucin core protein between the Pan-MECs and pancreatic ASCs-NOS. Pan-MEC is histologically and biologically high-grade and unrelated to CRTC1/3-MAML2 fusion gene, unlike Sal-MEC which is related to CRTC1/3-MAML2 fusion gene. Pan-MEC is not a pancreatic counterpart of CRTC1/3-MAML2 fusion gene-related Sal-MEC.


Assuntos
Biomarcadores Tumorais/genética , Carcinoma Adenoescamoso/genética , Carcinoma Mucoepidermoide/genética , Proteínas de Ligação a DNA/genética , Fusão Gênica , Proteínas Nucleares/genética , Neoplasias Pancreáticas/genética , Neoplasias das Glândulas Salivares/genética , Fatores de Transcrição/genética , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/análise , Biópsia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/classificação , Carcinoma Adenoescamoso/patologia , Carcinoma Mucoepidermoide/química , Carcinoma Mucoepidermoide/classificação , Carcinoma Mucoepidermoide/patologia , Feminino , Rearranjo Gênico , Predisposição Genética para Doença , Humanos , Imuno-Histoquímica , Hibridização in Situ Fluorescente , Masculino , Pessoa de Meia-Idade , Mucinas/análise , Gradação de Tumores , Neoplasias Pancreáticas/química , Neoplasias Pancreáticas/classificação , Neoplasias Pancreáticas/patologia , Fenótipo , Estudos Retrospectivos , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Neoplasias das Glândulas Salivares/química , Neoplasias das Glândulas Salivares/classificação , Neoplasias das Glândulas Salivares/patologia , Terminologia como Assunto
3.
Pol J Pathol ; 69(1): 93-97, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29895133

RESUMO

We present a very rare case of an adenosquamous infiltrating breast carcinoma with sarcomatous stromal overgrowth of hypocellular collagenised type, which subsequently developed local recurrence, mistaken for a benign skin lesion due to bland keloid-like morphological appearance. All the histological, immunohistochemical, and clinical features must be taken into consideration when distinguishing between a benign skin lesion and a local recurrence of a rare subtype of breast carcinoma.


Assuntos
Neoplasias da Mama/patologia , Carcinoma Adenoescamoso/patologia , Recidiva Local de Neoplasia/patologia , Neoplasias Cutâneas/patologia , Idoso , Biomarcadores Tumorais/análise , Biópsia , Neoplasias Encefálicas/secundário , Neoplasias da Mama/química , Neoplasias da Mama/terapia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/secundário , Carcinoma Adenoescamoso/terapia , Diagnóstico Diferencial , Evolução Fatal , Feminino , Humanos , Imuno-Histoquímica , Invasividade Neoplásica , Recidiva Local de Neoplasia/química , Valor Preditivo dos Testes , Neoplasias Cranianas/secundário , Tomografia Computadorizada por Raios X
4.
Medicine (Baltimore) ; 96(46): e8785, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29145336

RESUMO

RATIONALE: Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma which is generally recognized as a characteristic subgroup of triple-negative breast cancers previously. However, in this study, we reported for the first time a case of LGASC with hormone receptors expression. PATIENT CONCERNS: Pathological analysis of breast tumor specimen obtained by a 42-year-old female patient was performed. Morphologically, it composed of glandular structures with scattered squamous differentiation accompanied by haphazard arrangement of spindle cell stroma. Immunohistochemically, all myoepithelial and squamous differentiation markers showed typical LGASC positive or negative staining pattern. Interestingly, we found that normally aberrant hormone receptors were reactivated in this case. To our knowledge, this is the first report of a hormone receptor-positive LGASC. Apart from this, in the extended resection sample, we found scattered squamous metaplasia and florid adenosquamous proliferation (ASP). Meanwhile, it was positive for CD44 variant isoforms (CD44v), which is a breast cancer stem cell (CSC) marker, and expressed in LGASC, squamous metaplasia, and ASP. DIAGNOSIS: LGASC with hormone receptors expression. INTERVENTIONS: The breast-extended local excision and axillary lymph node dissection were performed. OUTCOMES: The patient was free of local recurrence and distant metastasis 6 months after surgical resection. LESSONS: We herein report the first case of LGASC with immunoreactivity for hormone receptors, expanding its profile of immunophenotypes. CD44v may play an important role in the transition of LGASC precursor lesions into malignant processes, which may serve as a therapeutic target in LGASC.


Assuntos
Neoplasias da Mama/química , Carcinoma Adenoescamoso/química , Receptores de Hialuronatos/análise , Adulto , Mama/patologia , Neoplasias da Mama/patologia , Carcinoma Adenoescamoso/patologia , Feminino , Humanos , Imuno-Histoquímica
5.
World J Gastroenterol ; 23(14): 2601-2612, 2017 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-28465645

RESUMO

AIM: To investigate the expression and clinical pathological significance of ROR2 and WNT5a in gallbladder squamous/adenosquamous carcinoma (SC/ASC) and adenocarcinoma (AC). METHODS: EnVision immunohistochemistry was used to stain for ROR2 and WNT5a in 46 SC/ASC patients and 80 AC patients. RESULTS: Poorly differentiated AC among AC patients aged > 45 years were significantly more frequent compared with SC/ASC patients, while tumors with a maximal diameter > 3 cm in the SC/ASC group were significantly more frequent compared with the AC group. Positive ROR2 and WNT5a expression was significantly lower in SC/ASC or AC with a maximal mass diameter ≤ 3 cm, a TNM stage of I + II, no lymph node metastasis, no surrounding invasion, and radical resection than in patients with a maximal mass diameter > 3 cm, TNM stage IV, lymph node metastasis, surrounding invasion, and no resection. Positive ROR2 expression in patients with highly differentiated SC/ASC was significantly lower than in patients with poorly differentiated SC/ASC. Positive ROR2 and WNT5a expression levels in highly differentiated AC were significantly lower than in poorly differentiated AC. Kaplan-Meier survival analysis showed that differentiation degree, maximal mass diameter, TNM stage, lymph node metastasis, surrounding invasion, surgical procedure and the ROR2 and WNT5a expression levels were closely related to average survival of SC/ASC or AC. The survival of SC/ASC or AC patients with positive expression of ROR2 and WNT5a was significantly shorter than that of patients with negative expression results. Cox multivariate analysis revealed that poor differentiation, a maximal diameter of the mass ≥ 3 cm, TNM stage III or IV, lymph node metastasis, surrounding invasion, unresected surgery and positive ROR2 or WNT5a expression in the SC/ASC or AC patients were negatively correlated with the postoperative survival rate and positively correlated with mortality, which are risk factors and independent prognostic predictors. CONCLUSION: SC/ASC or AC patients with positive ROR2 or WNT5a expression generally have a poor prognosis.


Assuntos
Adenocarcinoma/química , Biomarcadores Tumorais/análise , Carcinoma Adenoescamoso/química , Neoplasias da Vesícula Biliar/química , Receptores Órfãos Semelhantes a Receptor Tirosina Quinase/análise , Proteína Wnt-5a/análise , Adenocarcinoma/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Adenoescamoso/mortalidade , Carcinoma Adenoescamoso/patologia , Carcinoma Adenoescamoso/cirurgia , Diferenciação Celular , Distribuição de Qui-Quadrado , China , Feminino , Neoplasias da Vesícula Biliar/mortalidade , Neoplasias da Vesícula Biliar/patologia , Neoplasias da Vesícula Biliar/cirurgia , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Invasividade Neoplásica , Estadiamento de Neoplasias , Modelos de Riscos Proporcionais , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento , Regulação para Cima
6.
Nihon Shokakibyo Gakkai Zasshi ; 113(9): 1564-71, 2016 09.
Artigo em Japonês | MEDLINE | ID: mdl-27593366

RESUMO

A 76-year-old woman was referred to our hospital with anorexia. Computed tomography revealed a tumor lesion measuring 110mm in the liver at S4/5 with calcification and swelling of a paraaortic lymph node. The gallbladder was not visualized. Histological examination of a biopsy specimen from the liver tumor revealed squamous cell and undifferentiated carcinomas, and several tumor markers were elevated. Therefore, we diagnosed the patient with gallbladder adenosquamous cell carcinoma T3N2M0 stage III. Because the serum parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels were significantly elevated, we suspected that PTHrP and G-CSF production occurred because of adenosquamous cell carcinoma in the gallbladder. We initiated chemotherapy with S-1.


Assuntos
Carcinoma Adenoescamoso/química , Neoplasias da Vesícula Biliar/química , Neoplasias da Vesícula Biliar/patologia , Fator Estimulador de Colônias de Granulócitos/sangue , Proteína Relacionada ao Hormônio Paratireóideo/sangue , Idoso , Biópsia , Carcinoma Adenoescamoso/diagnóstico por imagem , Evolução Fatal , Feminino , Neoplasias da Vesícula Biliar/diagnóstico por imagem , Fator Estimulador de Colônias de Granulócitos/biossíntese , Humanos , Proteína Relacionada ao Hormônio Paratireóideo/biossíntese
7.
Ann Pathol ; 36(1): 15-23, 2016 Jan.
Artigo em Francês | MEDLINE | ID: mdl-26746368

RESUMO

The precise distinction between adenocarcinoma and squamous cell carcinoma (SqCC) has become very important for determining the appropriate therapy for patients and more specifically to drive the use of tyrosine kinase inhibitors, pemetrexed, anti-VEGF monoclonal antibody and crizotinib. Squamous pearls and distinct intercellular bridges identify keratinizing SqCC. In non-keratinizing SqCC, immuno-histochemistry is required. Recent studies have shown p40 and TTF1 to be the two best markers of SqCC and adenocarcinoma respectively. Many morphological variants of SqCC have been described. Basaloid SqCC is a poorly differentiated epithelial tumor lacking squamous morphology but showing immuno-histochemical expression of squamous makers. The pronostic of basaloid carcinoma is considered poorer than that of other non-small cell lung cancers. Adenosquamous carcinoma shows components of both SqCC and adenocarcinoma. Both components must be clearly identified either on H&E or by immuno-histochemistry. The adenocarcinoma components justified a screening for gene rearrangements. Finally, the recent WHO classification of lung tumors did not change the criteria applying for the grading of preinvasive bronchial lesion.


Assuntos
Carcinoma Adenoescamoso/classificação , Carcinoma de Células Escamosas/classificação , Neoplasias Pulmonares/classificação , Biomarcadores Tumorais , Carcinoma in Situ/química , Carcinoma in Situ/patologia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/patologia , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/patologia , Proteínas de Ligação a DNA/análise , Humanos , Pneumopatias/patologia , Neoplasias Pulmonares/química , Neoplasias Pulmonares/patologia , Lesões Pré-Cancerosas/patologia , Fatores de Transcrição/análise , Proteínas Supressoras de Tumor/análise
8.
Hum Pathol ; 49: 99-106, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26826416

RESUMO

In pleomorphic, spindle cell, and giant cell carcinoma (PSCGC) of the lung, we wondered if an integrated diagnosis including morphological and immunohistochemical features could be related to molecular status. We performed immunohistochemistry on 35 PSCGCs against TTF1, napsin A, p40, ALK, ROS1, and c-MET. Mutational status regarding EGFR, KRAS, BRAF, HER2, and PIK3CA genes was established. Of 18 PSCGCs with adenocarcinomatous or "undifferentiated" carcinoma differentiation, 8 were mutated for EGFR (n = 1), KRAS (n = 2), BRAF (n = 1), HER2 (n = 3), and PIK3CA (n = 1). No PSCGC (0/4) with only squamous cell or adenosquamous (0/2) differentiation was mutated. c-MET overexpression was only seen in PSCGC with adenocarcinomatous or undifferentiated component (n = 5) without squamous cell component. ROS1 and ALK were negative. The presence of a "targetable mutation" was correlated to the presence of morphological or immunohistochemical adenocarcinomatous differentiation (P = .0137). Integrated diagnosis of an adenocarcinomatous component in PSCGC could be associated with the presence of targetable gene mutation. Because only PSCGC with adenocarcinomatous or undifferentiated carcinoma harbors mutations, whereas PSCGC with only squamous or adenosquamous differentiation does not in our study, this might represent a prescreening for patients with PSCGC to be tested for molecular targets. Our results emphasize that careful morphological examination and the use of immunohistochemistry might be useful for the selection of PSCGC tested for a mutational target.


Assuntos
Adenocarcinoma/diagnóstico , Adenocarcinoma/tratamento farmacológico , Antineoplásicos/uso terapêutico , Biomarcadores Tumorais , Carcinoma Adenoescamoso/diagnóstico , Carcinoma Adenoescamoso/tratamento farmacológico , Carcinoma de Células Gigantes/diagnóstico , Carcinoma de Células Gigantes/tratamento farmacológico , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/tratamento farmacológico , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/tratamento farmacológico , Terapia de Alvo Molecular , Adenocarcinoma/química , Adenocarcinoma/genética , Adenocarcinoma/patologia , Adenocarcinoma de Pulmão , Idoso , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Biópsia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/genética , Carcinoma Adenoescamoso/patologia , Carcinoma de Células Gigantes/química , Carcinoma de Células Gigantes/genética , Carcinoma de Células Gigantes/patologia , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/patologia , Diferenciação Celular , Análise Mutacional de DNA , Feminino , França , Predisposição Genética para Doença , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/química , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Masculino , Mutação , Seleção de Pacientes , Fenótipo , Valor Preditivo dos Testes , Estudos Retrospectivos
9.
World J Gastroenterol ; 21(14): 4385-90, 2015 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-25892891

RESUMO

An 80-year-old man was under annual surveillance esophagogastroduodenoscopy after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Two years after the initial ESD, a 0-IIc type metachronous EGC lesion, 8 mm in size, without an ulcer scar, was found in the gastric antrum. The estimated tumor depth was up to the mucosa, and biopsy revealed well and poorly differentiated adenocarcinoma. ESD was performed for this lesion and en bloc resection with negative margins was achieved. Histopathological examination revealed an adenosquamous carcinoma 8 mm in size invading the deep submucosal layer (1600 µm), with lymphovascular invasion, consistent with the diagnosis of non-curative resection. Additional gastrectomy was recommended for this patient; however, two months after the ESD, preoperative computed tomography revealed multiple liver metastases, and the patient was considered as an unsuitable candidate for surgical resection. Systemic chemotherapy was therefore started; however, the patient died of gastric cancer 27 mo after the second ESD. Early gastric adenosquamous carcinoma localized to the mucosa and submucosa is extremely rare and its clinical behavior is not well known. The present report is very significant in that it underscores the distinct possibility of gastric adenosquamous carcinoma being very aggressive and fatal even when detected at an early cancer.


Assuntos
Adenocarcinoma/cirurgia , Carcinoma Adenoescamoso/patologia , Dissecação/métodos , Gastrectomia/métodos , Mucosa Gástrica/patologia , Segunda Neoplasia Primária/patologia , Neoplasias Gástricas/patologia , Neoplasias Gástricas/cirurgia , Adenocarcinoma/patologia , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/análise , Biópsia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/secundário , Carcinoma Adenoescamoso/cirurgia , Quimioterapia Adjuvante , Detecção Precoce de Câncer , Endoscopia do Sistema Digestório , Evolução Fatal , Mucosa Gástrica/química , Mucosa Gástrica/cirurgia , Humanos , Imuno-Histoquímica , Neoplasias Hepáticas/secundário , Masculino , Invasividade Neoplásica , Segunda Neoplasia Primária/química , Reoperação , Neoplasias Gástricas/química , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Carga Tumoral
10.
Hist. ciênc. saúde-Manguinhos ; 22(1): 153-169, Jan-Mar/2015. graf
Artigo em Inglês | LILACS, BDS | ID: lil-741514

RESUMO

Brazilian foreign policy paradigms and changes in the global scenario since the Cold War created conditions for stronger ties between Brazil and Portuguese-speaking African countries. Recently, Brazil took the lead in regional integration processes and in South-South cooperation initiatives. These strategies and Fiocruz's acknowledged technical expertise resulted in its direct involvement in Brazilian foreign public health policy in the Community of Portuguese-Speaking Countries. Fiocruz developed cooperation projects in various areas, sharing its know-how and best practices in the most critical fields in partner countries, consolidating "public health framework cooperation" and contributing to diversifying Brazil's partners and promoting Brazil as a global actor.


Os paradigmas da política externa brasileira e as mudanças no cenário global desde a Guerra Fria criaram as condições para aproximação do Brasil com os países africanos de língua portuguesa. Recentemente, o Brasil tomou a liderança nos processos de integração regional e nas iniciativas de cooperação Sul-Sul. Essas estratégias e a reconhecida expertise técnica da Fiocruz abriram espaço para o envolvimento direto da instituição na política externa do Brasil com a Comunidade de Países de Língua Portuguesa na área da saúde. A Fiocruz desenvolveu projetos de cooperação em áreas diversas, compartilhando seu know-how e melhores práticas em áreas prioritárias dos países parceiros, consolidando a "cooperação estruturante em saúde" e contribuindo para a diversificação de parceiros do país e promovendo o Brasil como ator global.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Adenocarcinoma/química , Antígenos CD/análise , Caderinas/análise , Carcinoma Adenoescamoso/química , Neoplasias da Vesícula Biliar/química , Biomarcadores Tumorais/análise , Adenocarcinoma/secundário , Diferenciação Celular , Carcinoma Adenoescamoso/secundário , Neoplasias da Vesícula Biliar/patologia , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Metástase Linfática , Análise Multivariada , Invasividade Neoplásica , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Prognóstico , Modelos de Riscos Proporcionais , Fatores de Risco , Fatores de Tempo , Carga Tumoral
12.
World J Gastroenterol ; 20(43): 16381-6, 2014 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-25473201

RESUMO

Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma. Here, we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change. Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers, which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition. This case also indicated that a routine radical surgery without aggressive treatment strategies was still appropriate for adenosquamous carcinoma of the pancreas with sarcomatoid change.


Assuntos
Carcinoma Adenoescamoso/patologia , Neoplasias Pancreáticas/patologia , Sarcoma/patologia , Biomarcadores Tumorais/análise , Biópsia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/cirurgia , Transição Epitelial-Mesenquimal , Feminino , Humanos , Imuno-Histoquímica , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Pancreatectomia , Neoplasias Pancreáticas/química , Neoplasias Pancreáticas/cirurgia , Fenótipo , Sarcoma/química , Sarcoma/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Carga Tumoral
13.
Pathol Res Pract ; 210(6): 363-8, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24636838

RESUMO

Gallbladder cancer (GBC) is a rare, but highly aggressive cancer. The most common type of gallbladder cancer is adenocarcinoma (AC), while squamous cell/adenosquamous carcinoma (SC/ASC) is a rare type of gallbladder cancer. The clinicopathologic and biological characteristics of SC/ASC have not been well documented. In this study, the protein expression of N-cadherin and P-cadherin in 46 SC/ASCs and 80 ACs was measured using immunohistochemistry. We demonstrated that positive N-cadherin and P-cadherin expression were significantly associated with large tumor size, invasion, and lymph node metastasis of both SC/ASC and AC. In contrast, positive N-cadherin and P-cadherin expression were significantly associated with differentiation and TNM stage in only AC. Univariate Kaplan-Meier analysis showed that positive N-cadherin and P-cadherin expression, differentiation, tumor size, TNM stage, invasion, lymph node metastasis, and surgical curability were significantly associated with overall survival in both SC/ASC and AC patients. Multivariate Cox regression analysis showed that positive N-cadherin and P-cadherin expression are independent poor-prognostic factors in both SC/ASC and AC patients. Our study suggested that positive N-cadherin and P-cadherin expression closely correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer.


Assuntos
Adenocarcinoma/química , Antígenos CD/análise , Biomarcadores Tumorais/análise , Caderinas/análise , Carcinoma Adenoescamoso/química , Neoplasias da Vesícula Biliar/química , Adenocarcinoma/secundário , Adulto , Idoso , Carcinoma Adenoescamoso/secundário , Diferenciação Celular , Feminino , Neoplasias da Vesícula Biliar/patologia , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Invasividade Neoplásica , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Prognóstico , Modelos de Riscos Proporcionais , Fatores de Risco , Fatores de Tempo , Carga Tumoral
14.
Int J Clin Exp Pathol ; 7(12): 9032-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25674283

RESUMO

Primary urinary bladder adenosquamous carcinoma is extremely rare and only a few cases have been reported in English literatures. Its biological behavior remains unclear. Here we reported a 60-year-old male patient with lower limb deep venous thromboses associated with primary urinary bladder adenosquamous carcinoma. A color ultrasonography showed right stock total venous thrombosis and right great saphenous vein thrombosis of lower limb. Contrast-enhanced computed tomography (CT) scan confirmed a 3.17 × 3.33 × 3.84 cm enhancing mass within the urinary bladder along the right lateral and posterior wall. Histopathological examination revealed adenosquamous carcinoma of urinary bladder, with extensive infiltration of the muscle layer. To the best of our knowledge, this is the first report of primary urinary bladder adenosquamous carcinoma complicated with deep venous thromboses in lower limb.


Assuntos
Carcinoma Adenoescamoso/complicações , Extremidade Inferior/irrigação sanguínea , Veia Safena , Neoplasias da Bexiga Urinária/complicações , Trombose Venosa/etiologia , Biomarcadores Tumorais/análise , Biópsia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/patologia , Carcinoma Adenoescamoso/cirurgia , Meios de Contraste , Cistectomia , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Veia Safena/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Ultrassonografia Doppler em Cores , Neoplasias da Bexiga Urinária/química , Neoplasias da Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/cirurgia , Filtros de Veia Cava , Trombose Venosa/diagnóstico , Trombose Venosa/terapia
15.
Int J Clin Oncol ; 19(2): 325-35, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23592278

RESUMO

BACKGROUND: The differences in clinical, pathological, and biological characteristics between adenocarcinoma (AC) and squamous cell/adenosquamous carcinoma (SC/ASC) of gallbladder cancer have not been well documented. This study is to compare the clinicopathological characteristics and FGFBP1 and WISP-2 expression between AC and SC/ASC patients. METHODS: We examined FGFBP1 and WISP-2 expression in 46 SC/ASC and 80 AC samples using immunohistochemistry and analyzed their correlations with clinicopathological characteristics. RESULTS: SC/ASCs occur more frequently in older patients and often correspond to larger tumor masses than ACs. Positive FGFBP1 and negative WISP-2 expression were significantly associated with lymph node metastasis and invasion of SC/ASCs and ACs. In addition, positive FGFBP1 and negative WISP-2 expression were significantly associated with differentiation and TMN stage in ACs. Univariate Kaplan-Meier analysis showed that either elevated FGFBP1 (p < 0.001) or lowered WISP-2 (p < 0.001) expression was closely associated with decreased overall survival in both SC/ASC and AC patients. Multivariate Cox regression analysis showed that positive FGFBP1 expression (p = 0.001) or negative WISP-2 expression (p = 0.035 for SC/ASC and p = 0.009 for AC) is an independent predictor of poor prognosis in both SC/ASC and AC patients. We also revealed that differentiation, tumor size, TNM stage, lymph node metastasis, invasion, and surgical procedure were associated with survival of both SC/ASC and AC patients. CONCLUSION: Our study suggested that the overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.


Assuntos
Adenocarcinoma/patologia , Proteínas de Sinalização Intercelular CCN/análise , Carcinoma Adenoescamoso/patologia , Carcinoma de Células Escamosas/patologia , Proteínas de Transporte/análise , Neoplasias da Vesícula Biliar/patologia , Peptídeos e Proteínas de Sinalização Intercelular/análise , Proteínas Repressoras/análise , Adenocarcinoma/química , Adenocarcinoma/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Proteínas de Sinalização Intercelular CCN/fisiologia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/mortalidade , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/mortalidade , Proteínas de Transporte/fisiologia , Feminino , Neoplasias da Vesícula Biliar/química , Neoplasias da Vesícula Biliar/mortalidade , Humanos , Imuno-Histoquímica , Peptídeos e Proteínas de Sinalização Intercelular/fisiologia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Modelos de Riscos Proporcionais , Proteínas Repressoras/fisiologia
16.
Int J Clin Exp Pathol ; 6(11): 2625-30, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24228131

RESUMO

The occurrence of metastasis of a systemic neoplasm to an intracranial tumor is a rare phenomenon. Meningiomas have been reported as the most common intracranial tumor to harbor a systemic metastasis, with breast and lung carcinomas being the most common sites of origination. Here, we report a case of an adenocarcinoma metastasis of an adenosquamous lung carcinoma found within a meningioma, resulting in the patient's first clinical manifestations. We also review the literature for other cases of adenocarcinoma metastatic to a meningioma and suggest mechanisms that make meningiomas likely to harbor systemic metastases including increased vascularity, slow growth rate, increased hyaline content and expression of cell-cell adhesion molecules.


Assuntos
Adenocarcinoma/secundário , Carcinoma Adenoescamoso/secundário , Neoplasias Pulmonares/patologia , Neoplasias Meníngeas/secundário , Meningioma/patologia , Adenocarcinoma/química , Adenocarcinoma/terapia , Adenocarcinoma de Pulmão , Biomarcadores Tumorais/análise , Biópsia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/terapia , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/química , Neoplasias Pulmonares/terapia , Masculino , Neoplasias Meníngeas/química , Neoplasias Meníngeas/terapia , Meningioma/química , Meningioma/terapia , Pessoa de Meia-Idade
17.
Gan To Kagaku Ryoho ; 40(6): 799-802, 2013 Jun.
Artigo em Japonês | MEDLINE | ID: mdl-23863662

RESUMO

We report a case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor (G-CSF). A 60- year-old man was admitted to our hospital complaining of upper abdominal pain. Endoscopic examination revealed a large type 5 advanced gastric cancer with bleeding from the low body of stomach to the antrum, accompanied with para-aortic and mesenteric lymph node metastasis. He had marked leukocytosis, and serum levels of G-CSF were elevated. Histological diagnosis of the biopsy specimen was adenosquamous carcinoma producing G-CSF. We attempted combination chemotherapy with docetaxel, cisplatin and S-1(DCS). After 1 course of treatment, the primary lesion was reduced in size. However, the size of the metastatic lymph node was larger. Chemotherapy was not effective enough, and the patient died 3 months after ending chemotherapy.


Assuntos
Biomarcadores Tumorais/sangue , Carcinoma Adenoescamoso/química , Fator Estimulador de Colônias de Granulócitos/sangue , Neoplasias Gástricas/química , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biomarcadores Tumorais/biossíntese , Biópsia , Carcinoma Adenoescamoso/tratamento farmacológico , Carcinoma Adenoescamoso/metabolismo , Carcinoma Adenoescamoso/patologia , Cisplatino/uso terapêutico , Docetaxel , Combinação de Medicamentos , Evolução Fatal , Fator Estimulador de Colônias de Granulócitos/química , Humanos , Masculino , Ácido Oxônico/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Neoplasias Gástricas/metabolismo , Neoplasias Gástricas/patologia , Taxoides/uso terapêutico , Tegafur/uso terapêutico , Tomografia Computadorizada por Raios X
19.
Asian Cardiovasc Thorac Ann ; 21(2): 231-4, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24532631

RESUMO

We describe a case of pleomorphic carcinoma showing a recurrent tumor with massive hemorrhage and myxoid change in the chest wall 2 months after complete resection. Whereas specimens from the initial surgery revealed both adenosquamous carcinoma and sarcomatous elements, the recurrent tumor predominantly consisted of a sarcomatous element. The recurrent tumor had stronger immunoreactivity for mesenchymal markers than the primary tumor, indicating that the sarcomatous element had more malignant potential than the epithelial element.


Assuntos
Carcinoma Adenoescamoso/patologia , Neoplasias Pulmonares/patologia , Recidiva Local de Neoplasia , Neoplasias Complexas Mistas/patologia , Sarcoma/patologia , Idoso , Autopsia , Biomarcadores Tumorais/análise , Biópsia , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/complicações , Carcinoma Adenoescamoso/cirurgia , Progressão da Doença , Evolução Fatal , Hemorragia/etiologia , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/química , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/cirurgia , Masculino , Neoplasias Complexas Mistas/química , Neoplasias Complexas Mistas/complicações , Neoplasias Complexas Mistas/cirurgia , Pneumonectomia , Sarcoma/química , Sarcoma/complicações , Sarcoma/cirurgia , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento
20.
Turk Patoloji Derg ; 28(2): 134-41, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22627631

RESUMO

OBJECTIVE: Metaplastic carcinoma is a rare tumor showing high histological grade and low hormone receptor expression. It has pure epithelial and mixed types. Studies have suggested that metaplastic carcinomas may have a basal-like profile. Our aim was to evaluate the clinicopathological features of 11 metaplastic carcinomas and determine their resemblance to basal-like breast carcinomas regarding their morphological and immunohistochemical profile. MATERIAL AND METHOD: Eleven metaplastic carcinoma cases were reviewed for their histopathological features. All tumors but one were evaluated for the immunohistochemical expressions of the cytokeratin 5/6, cytokeratin 14 and epidermal growth factor receptor; and hormonal status was assessed. RESULTS: Four of eleven cases were carcinoma with chondroid metaplasia, 3 were adenosquamous carcinoma, 2 were squamous cell carcinoma and 2 were carcinosarcoma. The mean patient age was 53 years and the mean tumor size was 5,1 cm. Histological grade was 3 for all with a nuclear grade of 3. Average mitotic count was 31/10 high power fields. Four cases had a central scar, 5 had central necrosis and 7 had geographic necrosis. Tumor growth pattern was pushing in 6 cases and no carcinoma in-situ was identified in 5 cases. Seven of 10 patients had axillary lymph node metastasis. Seven of 10 cases were triple-negative (estrogen receptor-, progesterone receptor-, HER2-) and 6 of them were positive for cytokeratin 5/6 and/or epidermal growth factor receptor, consistent with basal-like immunophenotype. Cytokeratin 14 was positive in 7 cases. CONCLUSION: Metaplastic carcinomas are large-sized, high-grade tumors with prominent nuclear pleomorphism and frequent mitosis. They rarely overexpress hormone receptors and HER2 and generally have basal-like immunophenotype.


Assuntos
Biomarcadores Tumorais/análise , Neoplasias da Mama/química , Neoplasias da Mama/patologia , Carcinoma/química , Carcinoma/patologia , Carcinoma/secundário , Carcinoma Adenoescamoso/química , Carcinoma Adenoescamoso/patologia , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/patologia , Carcinossarcoma/química , Carcinossarcoma/patologia , Receptores ErbB/análise , Feminino , Humanos , Imuno-Histoquímica , Imunofenotipagem , Queratina-14/análise , Queratina-5/análise , Queratina-6/análise , Metaplasia , Pessoa de Meia-Idade , Índice Mitótico , Necrose , Gradação de Tumores , Fenótipo , Receptor ErbB-2/análise , Receptores Estrogênicos/análise , Receptores de Progesterona/análise , Carga Tumoral , Turquia
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