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1.
Eur Rev Med Pharmacol Sci ; 26(8): 2970-2974, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35503641

RESUMO

OBJECTIVE: Serotonin, which is a vasoactive amine, is an important neurotransmitter and is involved in many behavioral and psychological phenomena, such as pain, appetite, mood, and sleep. The primary purpose of our study was to investigate the effect of high-pressure administration of sterile physiological saline isotonic solution (HpPSIS) into nasal cavity and to determine the expression of the serotonin. PATIENTS AND METHODS:  The study was made in two branches, the previous with 14 volunteers, the subsequent study with 40 patients with mild anxiety disorder. The middle third of the inferior turbinate epithelial cells on the right nostril was scraped using a sterile curette and indicated as (pre), then, a spray of sterilized isotonic solution at high pressure on the left nostril was delivered, and 5 minutes later a similar stimulation was delivered on the same nostril. The stimulation was made with a specific spray dispenser. The middle third of the inferior turbinate epithelial cells on the left nostril was scraped using a sterile curette and indicated as (post). Then, based on the first part of our study, we started the second part and gave a treatment on forty new patients with anxiety disorder. RESULTS:  The results of these studies highlight the possibility of endogenous enhancement of serotonin by stimulation of mast cells. In the first part of the study, Serotonin significantly increased in protein extracts after treatment (64.35±5.33 vs. 10.97±2.17; unpaired two tailed t-test, t=9.8, df=24, p≤0.0001; F=6.035; DFn=12; DFd=12). In the second part of the study, in patients treated with HpPSIS, we observed improvement of mood, after one, two and three months, with a statistically significant reduction of DASS-21, while no reduction was observed in control patients, treated with normal pressure commercial spray. CONCLUSIONS:  This pilot study showed that the topical treatment of HpPHIS increases serotonin levels in nasal cavity. The observation reported in this study opens the way to a new valid strategy to enhance the level of endogenous serotonin. We observed a significant improvement of ASI on patients during HpPHIS therapy.


Assuntos
Cavidade Nasal , Serotonina , Administração Intranasal , Humanos , Soluções Isotônicas/metabolismo , Soluções Isotônicas/farmacologia , Cavidade Nasal/metabolismo , Projetos Piloto , Serotonina/metabolismo
2.
Neurol India ; 70(2): 784-787, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35532661

RESUMO

Nasoethmoidal schwannomas are rare lesions and their presentation with intracranial extension is even rarer. Here, a patient presenting with rhinorrhea, epistaxis, and proptosis of left eye was diagnosed with giant nasoethmoidal schwannoma extending to frontal lobe and orbit, which was managed with bifrontal craniotomy with endoscopic transnasal gross total excision. This being predominantly a benign lesion has good prognosis if total excision is achieved.


Assuntos
Estesioneuroblastoma Olfatório , Neurilemoma , Neoplasias Nasais , Craniotomia , Estesioneuroblastoma Olfatório/diagnóstico por imagem , Estesioneuroblastoma Olfatório/cirurgia , Humanos , Cavidade Nasal/diagnóstico por imagem , Cavidade Nasal/patologia , Cavidade Nasal/cirurgia , Neurilemoma/diagnóstico por imagem , Neurilemoma/cirurgia , Neoplasias Nasais/diagnóstico por imagem , Neoplasias Nasais/cirurgia
4.
J Otolaryngol Head Neck Surg ; 51(1): 19, 2022 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-35505412

RESUMO

BACKGROUND: The ability of saline irrigation to detach the mucous and the flow-limiting effect of the nasal valve has not been well explored. The objective of this study was to compare the removal efficiency of a novel irrigation device with an extended nozzle versus a classic rinse bottle. METHODS: Transparent casts of the unoperated sinonasal cavity were made by 3D printing. Yogurt was used to simulate mucous. The cast filled with 5 ml yogurt was fixed in six head positions and irrigated with 120 ml, 175 ml, and 240 ml dyed water through the novel device and the rinse bottle. The irrigation efficiency was the ratio of the weight of yogurt washed away divided by the total weight of yogurt. RESULTS: The irrigation stream of a long nozzle with a side opening was different from the irrigation stream of the outlet within the nasal vestibule. The novel devices presented with continuous water stream directly upwards to the anterior part of the olfactory cleft. Depending on different head positions, it was easy for the novel devices to achieve an irrigation efficiency of 100% when the cast was irrigated with 120 ml or 175 ml water. There was still a tiny amount of yogurt left in the olfactory cleft when the cast was irrigated with 240 ml water under each head position for the rinse bottle. The irrigation efficiency was volume-dependent, and the average irrigation efficiency of the rinse bottle at 240 ml only reached 69.1%. CONCLUSIONS: The novel irrigation device presented with superior nasal irrigation efficiency to the classic rinse bottle. A continuous water stream directly upwards to the anterior part of the olfactory cleft combined with an extended nozzle overcoming the flow-limiting effect of the nasal valve promotes nasal irrigation efficiency.


Assuntos
Cavidade Nasal , Lavagem Nasal , Humanos , Água
5.
J Indian Soc Pedod Prev Dent ; 40(1): 48-54, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35439883

RESUMO

Introduction: Mouth breathing is one of the most deleterious oral habits with a prevalence of 4%-6% among children. Due to the wide range of comorbidities associated with mouth breathing, early diagnosis and prompt treatment is indispensable. At present, there are very few objective methods available for the diagnosis of mouth breathing. The present study was planned to evaluate a possible correlation between nasal index (NI) and nasal cavity volume (NCV) among nasal and mouth breathers (MB). In addition, the average NCV of nasal and MB was also computed. The foresight of this research was to establish the significance of NI as an objective diagnostic tool for mouth breathing. Methods: This cross-sectional study was conducted among 8-11-year-old children. The NI was determined using a digital Vernier caliper and NCV was calculated using dolphin imaging. Results: There was a significant difference in NCV and nasal width (NW) in both groups, but no difference was seen in nasal height and NI. There was no statistically significant correlation between NCV and other parameters in both groups. Conclusion: The present study was a baseline analysis in this line. Even though this study did not reveal any significant correlation between both parameters, future studies are recommended to explore a plausible correlation.


Assuntos
Respiração Bucal , Cavidade Nasal , Criança , Tomografia Computadorizada de Feixe Cônico/métodos , Estudos Transversais , Humanos , Respiração Bucal/diagnóstico por imagem , Cavidade Nasal/diagnóstico por imagem
6.
Medicine (Baltimore) ; 101(10): e29006, 2022 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-35451397

RESUMO

RATIONALE: Neurilemmoma is a benign tumor derived from the Schwann cells of the nerve sheath. The highest incidence of neurilemmoma occurs in the head and neck region; however, the nose and paranasal sinuses are rarely involved. Less than 4% of these tumors involve the nasal cavity and paranasal sinuses. To date, only six cases of nasal vestibule neurilemmoma have been reported. PATIENT CONCERNS: Two patients (a 32-year-old man and a 42-year-old woman) visited our clinic with complaint of a lump in the left nasal vestibule. DIAGNOSIS: Histopathological examination and immunohistochemical staining confirmed a neurilemmoma. INTERVENTIONS: The mass was completely removed via an intranasal approach. OUTCOMES AND LESSONS: Neurilemmoma is easy to overlook because it occurs rarely in the nasal vestibule, but neurilemmoma needs to be considered as a differential diagnosis.


Assuntos
Neurilemoma , Neoplasias Nasais , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Cavidade Nasal/patologia , Cavidade Nasal/cirurgia , Neurilemoma/diagnóstico , Neurilemoma/patologia , Neurilemoma/cirurgia , Nariz/patologia , Neoplasias Nasais/diagnóstico , Neoplasias Nasais/patologia , Neoplasias Nasais/cirurgia
7.
PLoS Pathog ; 18(4): e1010402, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35395059

RESUMO

Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in characterization of B. pertussis virulence mechanisms. However, the biologically most relevant catarrhal disease stage and B. pertussis transmission has not been adequately reproduced in adult mice due to limited proliferation of the human-adapted pathogen on murine nasopharyngeal mucosa. We used immunodeficient C57BL/6J MyD88 KO mice to achieve B. pertussis proliferation to human-like high counts of 108 viable bacteria per nasal cavity to elicit rhinosinusitis accompanied by robust shedding and transmission of B. pertussis bacteria to adult co-housed MyD88 KO mice. Experiments with a comprehensive set of B. pertussis mutants revealed that pertussis toxin, adenylate cyclase toxin-hemolysin, the T3SS effector BteA/BopC and several other known virulence factors were dispensable for nasal cavity infection and B. pertussis transmission in the immunocompromised MyD88 KO mice. In contrast, mutants lacking the filamentous hemagglutinin (FhaB) or fimbriae (Fim) adhesins infected the nasal cavity poorly, shed at low levels and failed to productively infect co-housed MyD88 KO or C57BL/6J mice. FhaB and fimbriae thus appear to play a critical role in B. pertussis transmission. The here-described novel murine model of B. pertussis-induced nasal catarrh opens the way to genetic dissection of host mechanisms involved in B. pertussis shedding and to validation of key bacterial transmission factors that ought to be targeted by future pertussis vaccines.


Assuntos
Adesinas Bacterianas , Bordetella pertussis , Coqueluche , Toxina Adenilato Ciclase , Adesinas Bacterianas/metabolismo , Animais , Bordetella pertussis/genética , Modelos Animais de Doenças , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Fator 88 de Diferenciação Mieloide , Cavidade Nasal/microbiologia , Vacina contra Coqueluche , Fatores de Virulência de Bordetella/genética , Coqueluche/transmissão
8.
Artigo em Chinês | MEDLINE | ID: mdl-35483696

RESUMO

The mechanism of nasal airflow perception remains little known. It is currently believed that the main mechanism for perceiving nasal patency is to activate transient receptor potential melastatin subtype 8. Computer fluent dynamics show that increased airflow and heat flux are associated with higher subjective scores. Similarly, physical measurements of the nasal cavity using a temperature probe show a correlation between the lower nasal mucosa temperature and better results. Trigeminal function detection also indirectly confirms this. This literature review aimed to explore the role of nasal mucosal temperature change in the subjective perception of nasal patency and the secondary aim was to appraise the relevant evidence about the mechanism.


Assuntos
Cavidade Nasal , Mucosa Nasal , Temperatura Corporal/fisiologia , Humanos , Cavidade Nasal/fisiologia , Mucosa Nasal/fisiologia , Percepção/fisiologia , Temperatura
9.
Rinsho Ketsueki ; 63(3): 229-232, 2022.
Artigo em Japonês | MEDLINE | ID: mdl-35387938

RESUMO

A 72-year-old woman was diagnosed with extranodal NK/T cell lymphoma of the right nasal cavity and received sequential radiochemotherapy comprising focal radiotherapy and THP-COP chemotherapy. Showed a complete tumor response to the treatment; however, the tumor recurred in the contralateral right nasal cavity 15 years after the initial treatment. This was judged to be a marginal recurrence in the radiation field. After four cycles of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy, a second complete response was achieved. It is possible that another recurrence occurs in the future, and if the lesion is localized at the time of recurrence, it may be possible to control the disease again. Careful follow-up is considered necessary.


Assuntos
Linfoma Extranodal de Células T-NK , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Asparaginase/uso terapêutico , Quimiorradioterapia , Feminino , Humanos , Ifosfamida/uso terapêutico , Linfoma Extranodal de Células T-NK/patologia , Linfoma Extranodal de Células T-NK/terapia , Cavidade Nasal/patologia , Resultado do Tratamento
10.
J Korean Med Sci ; 37(11): e88, 2022 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-35315599

RESUMO

Nasopharyngeal swabs have been widely to prevent the spread of coronavirus disease 2019 (COVID-19). Nasopharyngeal COVID-19 testing is a generally safe and well-tolerated procedure, but numerous complications have been reported in the media. Therefore, the present study aimed to review and document adverse events and suggest procedural references to minimize preventable but often underestimated risks. A total of 27 articles were selected for the review of 842 related documents in PubMed, Embase, and KoreaMed. The complications related to nasopharyngeal COVID-19 testing were reported to be rarely happened, ranging from 0.0012 to 0.026%. Frequently documented adverse events were retained swabs, epistaxis, and cerebrospinal fluid leakage, often associated with high-risk factors, including severe septal deviations, pre-existing skull base defects, and previous sinus or transsphenoidal pituitary surgery. Appropriate techniques based on sufficient anatomical knowledge are mandatory for clinicians to perform nasopharyngeal COVID-19 testing. The nasal floor can be predicted by the line between the nostril and external ear canal. For safe testing, the angle of swab insertion in the nasal passage should remain within 30° of the nasal floor. The swab was gently inserted along the nasal septum just above the nasal floor to the nasopharynx and remained on the nasopharynx for several seconds before removal. Forceful insertion should be attempted, and alternative examinations should be considered, especially in vulnerable patients. In conclusion, patients and clinicians should be aware of rare but possible complications and associated high-risk factors. The suggested procedural pearls enable more comfortable and safe nasopharyngeal COVID-19 testing for both clinicians and patients.


Assuntos
Teste para COVID-19/métodos , COVID-19/diagnóstico , Nasofaringe/virologia , SARS-CoV-2/isolamento & purificação , Manejo de Espécimes/efeitos adversos , Humanos , Cavidade Nasal/anatomia & histologia , Cavidade Nasal/virologia , Nasofaringe/anatomia & histologia , Manejo de Espécimes/métodos
11.
Head Neck Pathol ; 16(1): 1-18, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35312976

RESUMO

The World Health Organization Classification of Head and Neck Tumours recently published the 5th edition. There are new entities, emerging entities, and significant updates to the taxonomy and characterization of tumor and tumor-like lesions, specifically in this article as it relates to nasal cavity, paranasal sinuses and skull base. Importantly, the number of diagnostic entries has been reduced by creating category-specific chapters for soft tissue, hematolymphoid, melanocytic, neuroectodermal, and metastatic tumors. Bone and salivary gland tumors are also not separately reported in the sinonasal tract, but included in the jaw and salivary gland sections, respectively. Repetition of characteristic entities in each anatomic site was also reduced, instead highlighting only the unique features in each anatomic site. Two new entities (SWI/SNF complex-deficient sinonasal carcinomas and HPV-related multiphenotypic sinonasal carcinoma) will be highlighted in this review, with a discussion of several emerging entities. There is a short description of updated information for all 24 diagnostic entities included in this edition to allow the reader a snapshot of current state of knowledge, but to encourage more investigation and further broaden understanding of these diverse and rare entities.


Assuntos
Carcinoma , Neoplasias dos Seios Paranasais , Seios Paranasais , Carcinoma/patologia , Humanos , Cavidade Nasal/patologia , Neoplasias dos Seios Paranasais/patologia , Seios Paranasais/patologia , Base do Crânio/patologia , Organização Mundial da Saúde
12.
J Healthc Eng ; 2022: 4140682, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35295169

RESUMO

In this article, we have explored the effects of endoscopic sinus surgery together with budesonide treatment on nasal function and serum inflammatory factors on patients with chronic sinusitis. We retrospectively analyzed 120 patients with chronic sinusitis who were admitted to our hospital from March 2018 to March 2021 and were eligible for this study. They were separated into 2 groups according to different treatments, that is, the control group (treated with endoscopic surgery alone) of 58 cases and observation group (treated with endoscopic sinus surgery combined with budesonide) with 62 cases. Treatment efficacy, surgical status, overall symptom score before and after treatment, nasal mucociliary clearance function, serum eosinophils (EOS), serum immunoglobulin E (IgE), serum inflammatory factors, and occurrence of adverse reactions of both groups were recorded and compared. Total effective rate in the observation group presented strikingly more positive compared with that among patients in control group (P<0.05), as well as the data recorded in terms of operation time, blood loss during surgery and postoperative improvement time of patients (P<0.05). Overall symptom score, nasal mucociliary clearance, EOS, IgE and serum inflammatory factors in both groups were improved notably after treatment, while the observation group held a more obvious improvement. And it also had a markedly lower incidence of adverse reaction (P<0.05). Endoscopic sinus surgery combined with budesonide in the treatment of chronic sinusitis could effectively improve the clinical symptoms of patients, reestablish the function of the nasal cavity and improve their inflammation level. Meanwhile, it was of high safety and is worthy of clinical promotion.


Assuntos
Cavidade Nasal , Sinusite , Budesonida/uso terapêutico , Doença Crônica , Endoscopia , Humanos , Imunoglobulina E/uso terapêutico , Inflamação/tratamento farmacológico , Estudos Retrospectivos , Sinusite/tratamento farmacológico , Sinusite/cirurgia
13.
BMC Anesthesiol ; 22(1): 62, 2022 03 07.
Artigo em Inglês | MEDLINE | ID: mdl-35255824

RESUMO

BACKGROUND: The application of a surgical face mask over oxygen delivery devices is now a widespread recommendation in the setting of the Coronavirus disease pandemic. This addition is designed to reduce droplet spread, but this also changes the nature of these devices, and may alter the amount of oxygen delivered to a patient. This research investigated how placing a surgical face mask over both a simple plastic mask ("Hudson mask") and nasal cannula altered the concentration of available oxygen measured at the nares. METHODS: We measured the inspired and end-tidal oxygen concentrations of five healthy non-smoking volunteers. Oxygen was delivered via nasal cannula and also a simple plastic face mask, at flow rates of 2, 4, 6 and 8 l per minute, with and without an overlying surgical face mask. RESULTS: Adding a surgical mask over nasal cannula caused an appreciable rise in the end-tidal oxygen concentrations at all the measured oxygen flow rates 2, 4, 6, 8 L/minute. With the Hudson mask, there was a rise in oxygen concentration at 4 and 6 L/minute. For example, at a flow rate of 4 l/min via nasal cannula, available oxygen concentration increased from 24 to 36%, and via the Hudson mask the concentration rose from 27 to 38%. CONCLUSIONS: The addition of a surgical face mask over both nasal cannula and a Hudson mask resulted in an increased available oxygen concentration. This may be valuable where more advanced oxygen devices are not available, or alternatively providing adequate supplemental oxygen at lower flow rates and thus making critical savings in oxygen usage.


Assuntos
Máscaras , Oxigenoterapia/instrumentação , Oxigenoterapia/métodos , Oxigênio/administração & dosagem , Oxigênio/metabolismo , Adulto , Cânula , Estudos Cross-Over , Feminino , Voluntários Saudáveis , Humanos , Masculino , Cavidade Nasal , Valores de Referência
14.
Acta Med Okayama ; 76(1): 93-98, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35237005

RESUMO

A 66-year-old man underwent multimodal treatment for olfactory neuroblastoma (ONB). When he was 72 years old, a cystic intracranial lesion without accumulation on fluorine-18-fluorodeoxyglucose positron emission tomography was detected. Surgical resection was performed when the patient was 73 years old. The pathological examination revealed recurrence of ONB, and the patient underwent focal irradiation. At age 81, he presented with a second recurrence in the right occipital lobe with radiological and pathological findings similar to the prior recurrence. This case suggests that pathological confirmation should be considered in cases with atypical radiological findings following the treatment of ONB.


Assuntos
Estesioneuroblastoma Olfatório/diagnóstico por imagem , Cavidade Nasal/patologia , Recidiva Local de Neoplasia/diagnóstico por imagem , Neoplasias Nasais/diagnóstico por imagem , Tomografia por Emissão de Pósitrons , Idoso , Idoso de 80 Anos ou mais , Radioisótopos de Flúor , Fluordesoxiglucose F18 , Humanos , Masculino , Tomografia Computadorizada por Raios X
15.
Fluids Barriers CNS ; 19(1): 20, 2022 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-35248089

RESUMO

BACKGROUND: Hydrocephalus (increased ventricular size due to CSF accumulation) is a common finding in human ciliopathies and in mouse models with genetic depletion of the multiciliated cell (MCC) cilia machinery. However, the contribution of MCC to CSF dynamics and, the mechanism by which impaired MCC function leads to hydrocephalus remains poorly understood. The aim of our study was to examine if defects in MCC ciliogenesis and cilia-generated CSF flow impact central nervous system (CNS) fluid homeostasis including glymphatic transport and solute waste drainage. METHODS: We used two distinct mouse models of MCC ciliopathy: MCC-specific CEP164 conditional knockout mice (FOXJ1-Cre;CEP164fl/fl (N = 10), 3-month-old) and p73 knock-out (p73-/- (N = 8), 5-month-old) mice. Age-matched, wild-type littermates for each of the mutants served as controls. Glymphatic transport and solute drainage was quantified using in vivo T1 mapping by magnetic resonance imaging (MRI) after CSF infusion of gadoteric acid. Brain morphometry and aquaporin 4 expression (AQP4) was also assessed. Intracranial pressure (ICP) was measured in separate cohorts. RESULTS: In both of the two models of MCC ciliopathy we found the ventriculomegaly to be associated with normal ICP. We showed that FOXJ1-Cre;CEP164fl/fl mice with hydrocephalus still demonstrated sustained glymphatic transport and normal AQP4 expression along capillaries. In p73-/- mice glymphatic transport was even increased, and this was paralleled by an increase in AQP4 polarization around capillaries. Further, solute drainage via the cribriform plate to the nasal cavity was severely impaired in both ciliopathy models and associated with chronic rhinitis and olfactory bulb hypoplasia. CONCLUSIONS: The combination of sustained glymphatic transport, impaired solute drainage via the cribriform plate to the nasal cavity and hydrocephalus has not previously been reported in models of MCC ciliopathy. Our data enhance our understanding of how different types of ciliopathies contribute to disruption of CNS fluid homeostasis, manifested in pathologies such as hydrocephalus.


Assuntos
Ciliopatias , Sistema Glinfático , Hidrocefalia , Animais , Ciliopatias/genética , Ciliopatias/patologia , Drenagem , Sistema Glinfático/fisiologia , Hidrocefalia/patologia , Camundongos , Cavidade Nasal/patologia
16.
Microb Pathog ; 164: 105451, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35183701

RESUMO

Rhinoscleroma (RS) is a rare chronic specific progressive granulomatous disease of the upper airway and affect the nasal cavity, larynx, nasopharynx and may spread to the lower respiratory tract. Extra-respiratory involvement has rarely been described. A case report of extra-respiratory RS with oral manifestation in Egyptian female patient has been presented as a tumour extruded from mucosal lining of upper lip. She was living in crowded conditions with malnutrition and poor hygiene. On the first look, the lesion appeared to be carcinoma without any indication of infectious disease, and then patient was prepared for incisional biopsy. Upon clinicopathological evaluation, the diagnosis was made as RS in the granulomatous stage based on the presence of dense plasma cell infiltration with Mikulicz cells and Russell bodies. Long term oral ciprofloxacin 500 mg twice/day was started as a single treatment. By the end of six weeks antibiotic therapy, the large granulomatous mass reached the cicatricial stage, became very stiff fibrotic mass with sclerotic scar, markedly indurated & significantly decreased in size. This case shows the significant of through clinical examination and lab investigations to achieve correct diagnosis.


Assuntos
Rinoscleroma , Ciprofloxacina/uso terapêutico , Feminino , Humanos , Cavidade Nasal/patologia , Nariz , Patologia Bucal , Rinoscleroma/diagnóstico , Rinoscleroma/patologia , Rinoscleroma/terapia
17.
Int J Numer Method Biomed Eng ; 38(4): e3581, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35142094

RESUMO

Air conditioning is a dual heat and mass transfer process, and the human nasal cavity achieves this through the mucosal wall surface, which is supplied with an energy source through the sub-epithelial network of capillaries. Computational studies of air conditioning in the nasal cavity have included temperature and humidity, but most studies solved these flow parameters separately, and in some cases, a constant mucosal surface temperature was used. Recent developments demonstrated that both heat and mass transfer need to be modeled. This work expands on existing modeling efforts in accounting for the nasal cavity's dual heat and mass transfer process by introducing a new subwall model, given in the Supplementary Materials. The model was applied to a pipe geometry, and a human nasal cavity was recreated from CT-scans, and six inhalation conditions were studied. The results showed that when the energy transfer from the latent heat of evaporation is included, there is a cooling effect on the mucosal surface temperature.


Assuntos
Temperatura Alta , Cavidade Nasal , Humanos , Umidade , Nariz , Temperatura
18.
Clin Neuropathol ; 41(3): 114-121, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35142285

RESUMO

Although angiogenesis plays an important role in tumor growth and invasion, its role in the progression of olfactory neuroblastoma (ONB) has rarely been published. The aim of the present research was to analyze the prognostic role of microvessel density (MVD) in ONB and its association with clinicopathological parameters. 70 ONB cases were assessed for immunohistochemical expression of CD31, CD34, CD105, VEGF, and VEGFR2. The expression of CD105-MVD was negatively associated with histological grade and tumor Kadish stage, and its expression was positively correlated with the expression of VEGF/VEGFR2. Low expression of CD105-MVD and high tumor histological grade were strongly associated with poor survival. Thus, CD105-MVD was demonstrated to be a valuable independent prognostic indicator for ONB. MVD is expected to be useful as an important marker to distinguish tumor histological grade.


Assuntos
Estesioneuroblastoma Olfatório , Neoplasias Nasais , Antígenos CD/metabolismo , Biomarcadores Tumorais/metabolismo , Endoglina , Humanos , Densidade Microvascular , Cavidade Nasal/metabolismo , Cavidade Nasal/patologia , Neovascularização Patológica/metabolismo , Neovascularização Patológica/patologia , Neoplasias Nasais/diagnóstico , Prognóstico , Receptores de Superfície Celular/metabolismo , Fator A de Crescimento do Endotélio Vascular/metabolismo
20.
Gulf J Oncolog ; 1(38): 82-85, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35156649

RESUMO

Incidence of multiple primary malignancies is reportedly increasing globally. Limited cases of triple metachronous cancers are available in the literature. Here, we report a case of a female with an unusual combination of triple metachronous malignancy over a span of 15 years involving endometrium, nasal cavity and rectosigmoid that has not been reported before in the literature. Keywords: multiple primary malignancy; triple metachronous cancer; nasal squamous cell cancer; endometrial cancer; recto-sigmoid cancer; Lynch Syndrome.


Assuntos
Neoplasias Colorretais Hereditárias sem Polipose , Segunda Neoplasia Primária , Neoplasias do Colo Sigmoide , Endométrio , Feminino , Humanos , Cavidade Nasal , Neoplasias do Colo Sigmoide/cirurgia
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