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1.
Skinmed ; 20(2): 97-104, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35532761

RESUMO

Autologous serum is a component taken from patient's blood after centrifugation to be used for the same patient. Lately, growth factors (GF) found in platelet-rich plasma (PRP) has been widely used as an alternative therapeutic modality in various medical fields. The benefits of using autologous serum effectively include reduced risk of hypersensitivity or allergic reactions as well as the reduced risk of transmission of infectious diseases; however, in practice, the availability of products with GF is still limited. This study aimed to review the latest evidences of using autologous serum therapy in dermatology. We searched and screened the study papers of past 5 years (2015 - 2020) through Pubmed Medline for the following topic: "Risks and benefits of autologous serum in the field of dermatology." The initial search obtained 333 papers, of which only 14 met the inclusion criteria: these included five papers on dermatology, seven on ophthalmology, and one paper each on plastic surgery and orthopedics. PRP serum contains GF, vitamins, hormones, and other components. GF contained in PRP is an effective therapeutic modality to be used in dermatology for wound healing, skin rejuvenation, acne scar, and androgenic alopecia. (SKINmed. 2022;20:97-104).


Assuntos
Dermatologia , Plasma Rico em Plaquetas , Alopecia/terapia , Cicatriz/terapia , Humanos , Rejuvenescimento
2.
Int J Yoga Therap ; 32(2022)2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-35533407

RESUMO

Burn scar contracture greatly limits function for burn survivors, particularly when the scarring crosses multiple joints. Previous research has identified fields of skin recruited during single joint motion, called cutaneous functional units (CFU), indicating that impairments may be seen distal to the injured tissue. This case report connects the principles of CFU and yoga-inspired therapy modalities in improving clinical outcomes for a burn survivor. The patient is a 38-year-old male who sustained deep partial-thickness electrical burns to his neck, chest, and bilateral upper extremities, presenting with significantly decreased range of motion. The patient attended physical therapy 4 days a week, where he performed a specific yoga asana program during each session. Outcomes including standard range of motion measures, the Vancouver Scar Scale (VSS), and the Neck Disability Index (NDI), which were recorded every 10 sessions. CFUs of cervical extension and shoulder flexion were analyzed via photographs comparing cutaneous position during specified yoga poses and resting anatomical position in standing. Over 30 visits, cervical and shoulder range of motion increased, although the VSS and NDI did not show significant improvement. Yoga poses showed overall cutaneous recruitment distal to the targeted joints, and burned skin was recruited similarly to nonburned skin in positions of stretch. Incorporating multijoint approaches for stretching, like yoga, appears to contribute to improved clinical range-of-motion outcomes when paired with traditional burn-rehabilitation interventions. Yoga poses involving multiple joints align with the principle of CFUs, warranting continued investigation.


Assuntos
Queimaduras , Contratura , Ioga , Adulto , Queimaduras/reabilitação , Queimaduras/terapia , Cicatriz/complicações , Cicatriz/terapia , Contratura/etiologia , Contratura/terapia , Humanos , Masculino , Extremidade Superior
3.
Stem Cell Res Ther ; 13(1): 176, 2022 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-35505357

RESUMO

This review aims at becoming a guide which will help to plan the experimental design and to choose adequate methods to assess the outcomes when testing cell-based products in the treatment of the damaged vocal folds. The requirements to preclinical trials of cell-based products remain rather hazy and dictated by the country regulations. Most parameters like the way the cells are administered, selection of the cell source, selection of a carrier, and design of in vivo studies are decided upon by each research team and may differ essentially between studies. The review covers the methodological aspects of preclinical studies such as experimental models, characterization of cell products, assessment of the study outcome using molecular, morphological and immunohistochemical analyses, as well as measuring the tissue physical properties. The unified recommendations to perform preclinical trials could significantly facilitate the translation of cell-based products into the clinical practice.


Assuntos
Cicatriz , Prega Vocal , Cicatriz/patologia , Cicatriz/terapia , Humanos , Transplante de Células-Tronco
4.
Ocul Surf ; 24: 83-92, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35247582

RESUMO

Drug induced cicatrizing conjunctivitis (DICC) is defined as a disease in which conjunctival cicatrization develops as a response to the chronic use of inciting topical and, rarely, systemic medications. DICC accounts for up to one third of cases of pseudopemphigoid, a large group of cicatrizing conjunctival diseases sharing similar clinical features to those of mucous membrane pemphigoid (MMP) but generally without the morbidity of progressive scarring or the need for systemic immunosuppression. The preservatives in topical anti-glaucoma medications (AGM) are the most frequently implicated inciting causes of DICC although topical antivirals, vasoconstrictors and mydriatics and some systemic drugs have been implicated. The literature review summarizes the classification, epidemiology, etiopathogenesis, histopathology, clinical presentation, diagnosis, management, and treatment outcomes of DICC in the context of a case series of 23 patients (42 eyes) with AGM induced DICC, from India and the UK. In this series all subjects reacted to preserved AGM with one exception, who also reacted to non-preserved AGM. At diagnosis >70% of eyes showed punctal scarring, inflammation, and forniceal shortening. Pemphigoid studies were negative in the 19/23 patients in whom they were carried out. DICC can be classified as non-progressive, progressive with positive pemphigoid immunopathology or progressive with negative pemphigoid immunopathology. It is unclear whether progressive DICC is a stand-alone disease, or concurrent (or drug induced) ocular MMP. Progressive cases should currently be treated as ocular MMP. The diagnosis can be made clinically when there is rapid resolution of symptoms and inflammation, usually within 1-16 weeks, after withdrawal of suspected inciting medications, ideally by temporary substitution of oral carbonic anhydrase inhibitors. If the response to withdrawal is uncertain, or the progression of inflammation and scarring continues then patients must be evaluated to exclude concurrent (or drug induced) MMP, and other potential causes of CC, for which the treatment and prognosis is different. Management, in addition to withdrawing inciting medications, may require short-term treatment of conjunctival inflammation with steroids, treatment of associated corneal disease with contact lenses or surface reconstructive surgery, control of intra-ocular pressure with non-preserved AGM and, in some, surgery for glaucoma or for trichiasis and entropion.


Assuntos
Conjuntivite , Penfigoide Mucomembranoso Benigno , Penfigoide Bolhoso , Cicatriz/diagnóstico , Cicatriz/etiologia , Cicatriz/terapia , Conjuntivite/tratamento farmacológico , Conjuntivite/terapia , Humanos , Inflamação , Metaloproteinases da Matriz , Penfigoide Mucomembranoso Benigno/diagnóstico , Penfigoide Mucomembranoso Benigno/terapia , Penfigoide Bolhoso/complicações
5.
Anal Cell Pathol (Amst) ; 2022: 3686863, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35251908

RESUMO

BACKGROUND: Post-burn hypertrophic scars commonly occur after burns. Studies that compare dermal substitutes with other treatment methods are insufficient. The purpose was to analyze the histopathological differences in hypertrophic burn scars after Matriderm®+split-thickness skin graft (STSG) and compare with AlloDerm®+STSG, STSG, full-thickness skin graft (FTSG), and normal skin. METHODS: Samples of unburned, normal skin and deep 2nd or 3rd degree burns were obtained from patients who experienced a burn injury in the past to at least 6 months before biopsy, which was performed between 2011 and 2012. All subjects received >6 months of treatment before the biopsy. Intervention groups were normal (63), STSG (28), FTSG (6), Matriderm® (11), and AlloDerm® (18). Immunohistochemical analyses of elastin, collagen I, collagen III, cluster of differentiation 31 (CD31), smooth muscle actin (α-SMA), and laminin from scar and control tissues were performed and compared. RESULTS: α-SMA vascular quantity and vessel width, stromal CD31, and basement membrane laminin expression were not significantly different between normal and intervention groups. Matriderm® group showed no significant difference in elastin, collagen III, stromal CD31 and α-SMA, CD31 vessel width, stromal α-SMA, vessel quantity and width, and laminin length compared to the normal group, meaning they were not significantly different from the normal skin traits. CONCLUSION: Dermal substitutes may be an optimal alternative to address the cosmetic and functional limitations posed by other treatment methods.


Assuntos
Cicatriz , Pele Artificial , Queimaduras/terapia , Cicatriz/patologia , Cicatriz/terapia , Humanos , Transplante de Pele/métodos
6.
Stem Cell Res Ther ; 13(1): 85, 2022 03 03.
Artigo em Inglês | MEDLINE | ID: mdl-35241151

RESUMO

BACKGROUND: Intrauterine adhesion and cesarean scar diverticulum are the main complications of poor healing after uterine injury. Human umbilical cord MSCs transplantation has been regarded as the most potential treatment in the clinic, the safety and efficacy of which in the clinic, however, remains unclear. METHODS: In this study, ten patients were enrolled: six with intrauterine adhesion and four with cesarean scar diverticulum. All the patients were injected with human umbilical cord MSCs twice into the uterus. Beside the chest X-ray, ECG and abdominal ultrasound, many laboratory tests including blood routine, liver and renal function, ovarian function, tumor biomarkers, and immune function were used to estimate the safe after stem cell transplanted. In addition, the efficacy of stem cell transplanted was shown by the endometrial thickness, the volume of the uterus, and cesarean scar diverticulum based on 3D ultrasound imaging. RESULTS: We found that all results of these laboratory tests were normal in these enrolled patients before and after cell injection. Meanwhile, the results of the chest X-ray and ECG were also normal in the treatment process. The abdominal ultrasound showed that the size of the left and right kidneys was inconsistent in one patient after cell therapy, while those of other patients were normal. In addition, endometrial thickness, the volume of the uterus, and cesarean scar diverticulum showed an improving tendency, but no significant difference was noted. CONCLUSION: In summary, intrauterine injection of clinically graded human umbilical cord MSCs was safe for poor healing after uterus injury. Trial registration NCT03386708. Registered 27 December 2017, https://clinicaltrials.gov/ct2/show/NCT03386708?cond=CSD&cntry=CN&draw=2&rank=2.


Assuntos
Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais , Cicatriz/diagnóstico por imagem , Cicatriz/patologia , Cicatriz/terapia , Feminino , Humanos , Transplante de Células-Tronco Mesenquimais/efeitos adversos , Transplante de Células-Tronco Mesenquimais/métodos , Gravidez , Cordão Umbilical , Útero/diagnóstico por imagem , Útero/patologia
7.
J Drugs Dermatol ; 21(3): 309-310, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-35254751

RESUMO

Platelet-rich plasma (PRP) is an autologous concentration of plasma from a patient’s blood containing platelets up to 7 times higher than normal plasma. Originally indicated to improve connective tissue regeneration in orthopedic surgery, PRP has also proven to be advantageous in the treatment of androgenic alopecia (AGA), alopecia areata (AA), and other forms of non-scarring alopecia.


Assuntos
Alopecia em Áreas , Lúpus Eritematoso Discoide , Plasma Rico em Plaquetas , Alopecia/etiologia , Alopecia/terapia , Alopecia em Áreas/etiologia , Alopecia em Áreas/terapia , Cicatriz/etiologia , Cicatriz/terapia , Humanos , Lúpus Eritematoso Discoide/complicações , Lúpus Eritematoso Discoide/diagnóstico , Lúpus Eritematoso Discoide/terapia , Transplante Autólogo
8.
Dermatol Ther ; 35(5): e15376, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35150195

RESUMO

Post acne scars following sebaceous injury and abnormal wound healing during the course of acne is a prevalent and challenging to treat condition To evaluate microneedling by dermapen with topical vitamin C versus microneedling with topical insulin in treating atrophic post-acne scars. A split-face comparative study included 30 subjects with atrophic post-acne scars. Human insulin was topically applied to the left side of the face and on the right side, vitamin C serum was applied. Scars were assessed via the Acne Scar Assessment Scale (ASAS) and Scar quartile grading scale (SQGS). After 1 month of 4 treatments, a statistically significant mean improvement in ASAS value was reported on both split sides of the face (2.13 and 1.83) compared to baseline (3.03 and 2.93) (p = 0.005; p = 0.001 respectively). When compared to baseline, the mean ASAS value improved significantly with a slight more improvement on the vitamin c treated side. Topical insulin and vitamin c combined with microneedling, may both achieve comparable significant improvement for treating post acne scars. Insulin can be a promising novel anti-scarring therapy pending larger controlled studies to verify its efficacy.


Assuntos
Acne Vulgar , Doenças do Tecido Conjuntivo , Técnicas Cosméticas , Acne Vulgar/complicações , Acne Vulgar/terapia , Ácido Ascórbico , Atrofia/terapia , Cicatriz/diagnóstico , Cicatriz/etiologia , Cicatriz/terapia , Técnicas Cosméticas/efeitos adversos , Humanos , Insulina , Agulhas , Resultado do Tratamento
10.
Wound Repair Regen ; 30(2): 210-221, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35146830

RESUMO

Literature provides a moderate level of evidence for the beneficial effects of incisional negative pressure wound therapy (iNPWT) on scar quality. The purpose of this study was to establish if iNPWT results in improved scar outcomes in comparison to the standard of care. Therefore, a within-patient randomised controlled, open-label trial was conducted in transgender men undergoing gender-affirming mastectomies. A unilateral side was randomised to receive iNPWT (PICO™, Smith&Nephew) without suction drains and contrastingly the standard dressing (Steri-Strips™) with suction drain. Scar quality and questionnaires were bilaterally measured by means of objective assessments and patient-reported outcome measures (PROM) at 1, 3 and 12 months. Objective scar outcomes were scar pliability (Cutometer®), colouration (DSM-II) and scar width (3-D imaging). PROM outcomes were related to scars (POSAS and SCAR-Q) and body satisfaction (BODY-Q). From 85 included patients, 80 were included for analyses. No significant difference between treatments was seen in the quantitative outcomes of scar pliability, colour, and width. For qualitative scar outcomes, several significant findings for iNPWT were found for several subscales of the POSAS, SCAR-Q, and BODY-Q. These effects could not be substantiated with linear mixed-model regression, signifying no statically more favourable outcome for either treatment option. In conclusion, this study demonstrated that some PROM outcomes were more favourable for the iNPWT compared to standard treatment. In contrast, the quantitative outcomes showed no beneficial effects of iNPWT on scar outcomes. This suggests that iNPWT is of little benefit as a scar-improving therapy.


Assuntos
Tratamento de Ferimentos com Pressão Negativa , Cicatriz/terapia , Humanos , Masculino , Tratamento de Ferimentos com Pressão Negativa/métodos , Medidas de Resultados Relatados pelo Paciente , Infecção da Ferida Cirúrgica/terapia , Cicatrização
11.
J Healthc Eng ; 2022: 6803988, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35126939

RESUMO

OBJECTIVE: To investigate the effect and safety of PRP and Yifu combined with ultrapulsed CO2 lattice laser in patients with sunken acne scar. METHODS: 700 subjects were selected from the group of patients with sunken acne scar treated in our hospital from November 2010 to December 2020. They were divided into control group (n = 350) and study group (n = 350). The grouping was mainly based on the random number table method. Patients in the control group were treated with ultrapulse CO2 lattice laser, while those in the study group were treated with ultrapulse CO2 lattice laser combined with PRP and Yifu. The clinical effect, scar improvement and quality of life before and after treatment, and adverse events during treatment were compared between the two groups. The clinical effect was categorized into cure after treatment, significant effect, effective, and ineffective. The total effective rate = 1 - ineffective rate. RESULTS: After treatment, the total effective rate of the study group (81.43%) was higher than that of the control group (70.00%). After treatment, ECCA, VSS scores, daily activities, symptoms and feelings, work and study, leisure and entertainment, interpersonal relationship, treatment status, and total scores were all lower in both groups than before treatment, and the study group was lower than the control group. During the treatment, the incidence of adverse events in the study group (17.33%) was lower than that in the control group (28.57%), P < 0.05. CONCLUSION: PRP and Yifu combined with ultrapulse CO2 lattice laser in the treatment of sunken acne scar can effectively improve the scar, reduce the incidence of adverse events, and the treatment effect is obvious, which can improve the quality of life of the patients.


Assuntos
Acne Vulgar , Lasers de Gás , Plasma Rico em Plaquetas , Acne Vulgar/complicações , Acne Vulgar/terapia , Dióxido de Carbono , Cicatriz/etiologia , Cicatriz/patologia , Cicatriz/terapia , Humanos , Lasers de Gás/uso terapêutico , Qualidade de Vida , Resultado do Tratamento
12.
Clin Dermatol ; 40(1): 19-28, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35190060

RESUMO

Platelet-rich plasma (PRP) has expanded its therapeutic applications into the field of aesthetic medicine. PRP is an autologous blood-derived product with an increased concentration of platelets to plasma relative to that of whole blood, which supports its therapeutic effects. Frequently promoted and marketed directly to consumers and patients, clinicians are often questioned on the efficacy and safety of PRP as a therapeutic modality. Given the rise in popularity of PRP, multiple clinical trials have been conducted to assess its application within the field of aesthetic medicine, particularly for hair loss conditions, skin rejuvenation, scarring, and conditions of dyspigmentation. We have reviewed the relevant research about the utility of PRP and associated evidence-based practices and discuss the direction for future research.


Assuntos
Plasma Rico em Plaquetas , Alopecia/terapia , Cicatriz/terapia , Estética , Humanos , Rejuvenescimento
13.
J Cosmet Dermatol ; 21(3): 991-997, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35064639

RESUMO

AIM AND OBJECTIVES: Evaluation of the cumulative effect of Radiofrequency Microneedling and fractional Erbium: Glass 1565 laser in moderate to severe acne scars in skin of color. MATERIAL AND METHODS: This retrospective study was conducted on 20 patients of skin types III -V having moderate to severe atrophic acne scars. The study was carried out over 1 year from March 2019 to March 2020. PROCEDURE: All patients underwent 4 sessions of non-ablative Fractional Erbium: Glass 1565 laser to alternate with 4 sessions of Fractional Radiofrequency Microneedling once a month over 8 months. RESULTS: Of the 20 patients enrolled, 18 completed treatment protocol. Two patients were withdrawn from the study because they were unable to attend follow-up treatment sessions. The subjective evaluation was performed using photographs at baseline, 8 months, and 12 months. A photographic evaluation was performed using the following numeric responses: <25%, 25-50%, 51-75%, and 76-100% difference in severity. None of the patients had worsening of their scars. The improvement in scars was statistically significant. CONCLUSION: The combination of Fractional Erbium: Glass 1565 laser and Fractional Radiofrequency Microneedling can be used in the treatment of acne scars in skin of color. Our protocols helped achieve significant improvement of scars.


Assuntos
Acne Vulgar , Lasers de Estado Sólido , Acne Vulgar/terapia , Cicatriz/etiologia , Cicatriz/patologia , Cicatriz/terapia , Érbio , Humanos , Lasers de Estado Sólido/uso terapêutico , Estudos Retrospectivos , Pigmentação da Pele , Resultado do Tratamento
14.
J Obstet Gynaecol Res ; 48(1): 140-145, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34755427

RESUMO

AIM: To introduce the novel use of lauromacrogol for cesarean scar pregnancy (CSP), and to compare the clinical efficacy and safety of curettage combined with ultrasound-guided sclerosant injection (USI) and curettage following uterine artery embolization (UAE) in the treatment of CSP. METHODS: CSP patients undergoing curettage combined with USI (n = 72) from December 2014 to May 2020 were compared to patient with curettage following UAE (n = 72).The basic clinical findings and clinical outcomes were reviewed between the two groups. RESULTS: For USI group, 69 patients underwent successful treatment (95.8% success rate), while the number of cured patients for the UAE group was 70 (97.2% success rate). Differences between USI group and UAE group in intraoperative blood loss (10.0 [10.0-20.0] vs. 10.0 [10.0-20.0] mL) and time for serum ß human chorionic gonadotropin (ß-hCG) to reduce to normal (28.0 [21.0-40.0] vs. 28.0 [21.0-35.0] days) were not statistically significant. The hospital stay for USI group was significantly shorter than that for UAE group (4.0 [4.0-6.0] vs. 6.0 [5.0-7.0] days, respectively). Statistically significant decreases were noted in hospitalization expenses and adverse events in USI group, compared to UAE group. There was no difference in live birth rate between the two groups with fertility intentions during the follow-up. CONCLUSION: For treatment of CSP, curettage combined with USI yielded clinical results comparable to those of curettage following UAE. Curettage combined with USI was associated with lower hospitalization expenses, shorter hospital stay and less complications, and it merited an effective and safe treatment for CSP.


Assuntos
Soluções Esclerosantes , Embolização da Artéria Uterina , Cesárea/efeitos adversos , Cicatriz/terapia , Feminino , Humanos , Metotrexato , Polidocanol , Gravidez , Estudos Retrospectivos , Resultado do Tratamento , Ultrassonografia de Intervenção
15.
Tissue Cell ; 74: 101676, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34798583

RESUMO

Both intrauterine adhesions (IUA) and premature ovarian failure (POF) have plagued women all over the world for a long time. It is well known that all invasive operations involving the uterus can disrupt its structural and functional integrity to a varying degree, which inevitably lead to abnormal scar formation, such as IUA, also known as Asherman's syndrome with symptoms like hypomenorrhea or infertility. Another reproductive disorder that causes infertility is primary ovarian insufficiency (POI) or POF, which is a degenerative phenomenon in the ovary among women under the age of 40. In recent years, various types of stem cells, especially mesenchymal stem cells (MSCs) have been widely used in reproductive medicine due to their properties, such as immunoregulation, anti-inflammation, angiogenesis, anti-apoptosis, and trophicity. However, the extensive clinical application of cell therapy is impeded by their safety, cost, and manufacturing. In this review, we sought to summarize the recent advances in using different types of MSCs in treating uterine scars and POF. We also describe several biological pathways and molecules involved in animal studies and clinical application; extracellular vesicles secreted by MSCs may be a promising attractive tool to ensure the treatment of infertility by restoring normal reproductive function.


Assuntos
Cicatriz/terapia , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais/metabolismo , Ovário/metabolismo , Insuficiência Ovariana Primária/terapia , Útero/metabolismo , Animais , Cicatriz/metabolismo , Feminino , Humanos , Insuficiência Ovariana Primária/metabolismo
16.
Dermatol Surg ; 48(2): 201-206, 2022 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-34889211

RESUMO

BACKGROUND: Despite history of multiple treatment modalities, repigmentation of hypopigmented scars remains a difficult clinical problem. OBJECTIVE: The purpose of this review is to evaluate the literature on laser and combination laser plus adjunct topical therapy for hypopigmented burn and traumatic scars. MATERIALS AND METHODS: A search on PubMed and on Oxford Academic was conducted with additional relevant literature obtained from reference lists. RESULTS: Treatment regimens that address hypopigmentation within scars were reviewed. A combination of nonablative fractional or ablative fractional laser treatment with topical prostaglandin analogue with or without topical retinoid were found to result in superior repigmentation. CONCLUSION: Reliable improvement of hypopigmentation in scars after laser treatment is challenging. Laser can achieve success in some cases. Ultraviolet laser can achieve modest repigmentation; however, results are short-lived and require continued re-treatment. Modest improvement in pigmentation is seen with nonablative fractional laser or ablative fractional laser alone and enhanced repigmentation is demonstrated when combining fractional laser resurfacing with topical application of synthetic prostaglandin analogues and other known modulators of melanogenesis.


Assuntos
Queimaduras , Hipopigmentação , Terapia a Laser , Lasers de Gás , Queimaduras/cirurgia , Cicatriz/etiologia , Cicatriz/patologia , Cicatriz/terapia , Humanos , Hipopigmentação/etiologia , Hipopigmentação/terapia , Terapia a Laser/métodos , Lasers de Gás/uso terapêutico , Retinoides , Resultado do Tratamento
17.
J Dermatolog Treat ; 33(1): 247-253, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32216729

RESUMO

BACKGROUND: Tissue filler injection is popular for tissue augmentation, but it is still not widely used for depressed scar correction because of the limitations of the existed materials. OBJECTIVE: This study was designed to observe the effects of a tissue-engineering filler derived from autologous skin and hairs for correction of moderate-severe depressed scars. PATIENTS AND METHODS: Totally 40 volunteers with moderate-severe depressed scars were enrolled in. Keratin gel and fibroblast derived from autologous hairs and a small piece of skin were mixed with autoserum and then injected into the dermis of the deformities. The whole procedure for injection was: filling and leveling up the scars by 10% after adequate subcision and repeating the treatment every other 3 weeks for total 9 weeks. Clinical features at different time points of the scars were collected and assessed. RESULTS: Thirty-six patients followed the protocol completely, receiving at least 50% improvement in depth and size of scars (significant improvement) 1 year after the treatment, with 88.9% of them had '75% improvement or more improvement' (excellent improvement). No severe complications were reported. CONCLUSION: Autologous keratin and fibroblast as filler is an effective option for moderate-severe depressed scars correction with long-term efficacy and high satisfactory.


Assuntos
Cicatriz , Envelhecimento da Pele , Cicatriz/etiologia , Cicatriz/patologia , Cicatriz/terapia , Cabelo , Humanos , Pele/patologia , Transplante Autólogo
18.
J Dermatolog Treat ; 33(2): 749-755, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32501765

RESUMO

OBJECTIVE: We aimed to evaluate the efficacy and safety of the 1,565 nm non-ablative fractional laser (NAFL) in combination with isotretinoin and pricking blood therapy (PBT) for treatment of AV. METHODS: A retrospective analysis of 60 patients with moderate-to-severe AV was performed. Four groups (n = 15) were evaluated: 1,565nm NAFL alone, oral isotretinoin alone, double therapy (NAFL + isotretinoin) and triple therapy (NAFL + isotretinoin + PBT). RESULTS: The triple therapy showed the highest improvement rate of inflammatory papules and boxcar atrophic scars. The patients receiving oral isotretinoin alone, double or triple therapy showed a significant decrease in volume of boxcar atrophic scars. The NAFL alone, double or triple therapy significantly decreased index of hemoglobin. Furthermore, the triple therapy significantly decreased indexes of hemoglobin and red areas as compared to the other three treatments. All four treatments significantly decreased indexes of pore sizes and wrinkles. CONCLUSION: This study showed that the triple therapy is effective for treatment of AV, which is worthy of further evaluation and investigation.


Assuntos
Acne Vulgar , Terapia a Laser , Lasers de Estado Sólido , Acne Vulgar/terapia , Cicatriz/etiologia , Cicatriz/patologia , Cicatriz/terapia , Humanos , Isotretinoína/uso terapêutico , Terapia a Laser/efeitos adversos , Estudos Retrospectivos , Resultado do Tratamento
19.
J Cosmet Dermatol ; 21(4): 1477-1481, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34021955

RESUMO

INTRODUCTION: There are currently not many publications on the safety of thermomechanical ablation (TMA) devices, and those that are published only have small numbers of subjects. This treatment is gaining popularity in Europe and Asia, and thus there is a need to look at the safety of this treatment. OBJECTIVE: The purpose of this retrospective study was to evaluate the safety of the clinical use of the novel TMA system (Tixel, Novoxel, Israel) for facial rejuvenation and treatment of acne scars. METHODS: We did a retrospective review of our first 150 patients who were treated with the TMA device. RESULTS: One hundred and fifty consecutive patients aged 20 years to 82 years with Fitzpatrick skin types I to V treated with the TMA device were included in this study. The total number of treatment sessions was 327 (average 2.18 treatment per patient). The total number of pulses delivered to these patients was 1 48 856 (average 455 pulses per session). The indications for the treatment were photodamaged skin (n=145) and acne scarring (n=5). All patients were able to use makeup immediately after the treatment at lower settings, thus needing no real recovery time. Patients treated at higher settings were able to use makeup after 2 days. There were four reported complications: post-inflammatory hyperpigmentation (n=2), impetigo (n=1), and dermatitis (n=1). CONCLUSIONS: Using the TMA device in the treatment of photodamage and acne scarring is safe in skin types I to V and has a low incidence of temporary side effects with no permanent side effects.


Assuntos
Acne Vulgar , Envelhecimento da Pele , Acne Vulgar/complicações , Acne Vulgar/terapia , Adulto , Cicatriz/etiologia , Cicatriz/patologia , Cicatriz/terapia , Humanos , Rejuvenescimento , Estudos Retrospectivos , Pele/patologia , Resultado do Tratamento , Adulto Jovem
20.
J Burn Care Res ; 43(1): 269-276, 2022 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-34015124

RESUMO

The incidence of pediatric treadmill hand friction burns has been increasing every year. The injuries are deeper than thermal hand burns, the optimal treatment remains unclear. This was a retrospective study of children who received surgery for treadmill hand friction burns from January 1, 2015, to December 31, 2019, in a single burn center. A total of 22 children were surveyed. The patients were naturally divided into two groups: the wound repair group (13 patients), which was admitted early to the hospital after injury and received debridement and vacuum sealing drainage initially, and a full-thickness skin graft later; and the scar repair group (nine patients), in which a scar contracture developed as a result of wound healing and received scar release and skin grafting later. The Modified Michigan Hand Questionnaire score in the wound repair group was 116.31 ± 10.55, and the corresponding score in the scar repair group was 117.56 ± 8.85 (p > .05), no statistically significant difference. The Vancouver Scar Scale score in the wound repair group was 4.15 ± 1.21, and the corresponding score in the scar repair group was 7.22 ± 1.09 (p < .05). Parents were satisfied with the postoperative appearance and function of the hand. None in the two groups required secondary surgery. If the burns are deep second degree, third degree, or infected, early debridement, vacuum sealing drainage initially, and a full-thickness skin graft can obviously relieve pediatric pain, shorten the course of the disease, and restore the function of the hand as soon as possible.


Assuntos
Queimaduras/etiologia , Queimaduras/terapia , Cicatriz/terapia , Traumatismos da Mão/etiologia , Traumatismos da Mão/terapia , Equipamentos Esportivos , Unidades de Queimados , Criança , Pré-Escolar , Cicatriz/etiologia , Desbridamento , Drenagem , Feminino , Fricção , Humanos , Masculino , Estudos Retrospectivos , Transplante de Pele , Inquéritos e Questionários , Cicatrização
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