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1.
Shanghai Kou Qiang Yi Xue ; 29(4): 445-448, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-33089300

RESUMO

PURPOSE: The aim of this study was to assess and compare patient satisfaction and time required between silicon rubber impression and intraoral scanning impression. METHODS: Six undergraduates participated in this study. silicon rubber impression and intraoral scanning impression were taken, the time required to obtain the impressions and the scores of visual analog scale(VAS) were recorded. SPSS 23.0 software package was used for statistical analysis. RESULTS: The time and patients satisfaction of silicon rubber impression were better than intraoral scanning impressions, and there were significant differences between the two groups(P<0.05). CONCLUSIONS: Using silicon rubber impression, the patient experience is better. To use intraoral scanning impression technology, dentists should be more skilled. With the role-playing method,dental interns can learn the operation key points and precautions of different impression-taking methods even better.


Assuntos
Borracha , Silício , Desenho Assistido por Computador , Técnica de Moldagem Odontológica , Humanos , Cintilografia
2.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1564-1567, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018291

RESUMO

Magnetic resonance imaging (MRI) has been one of the most powerful and valuable imaging methods for medical diagnosis and staging of disease. Due to the long scan time of MRI acquisition, k-space under-samplings is required during the acquisition processing. Thus, MRI reconstruction, which transfers undersampled k-space data to high-quality magnetic resonance imaging, becomes an important and meaningful task. There have been many explorations on k-space interpolation for MRI reconstruction. However, most of these methods ignore the strong correlation between target slice and its adjacent slices. Inspired by this, we propose a fully data-driven deep learning algorithm for k-space interpolation, utilizing the correlation information between the target slice and its neighboring slices. A novel network is proposed, which models the inter-dependencies between different slices. In addition, the network is easily implemented and expended. Experiments show that our methods consistently surpass existing image-domain and k-space-domain magnetic resonance imaging reconstructing methods.


Assuntos
Aprendizado Profundo , Processamento de Imagem Assistida por Computador , Imagem por Ressonância Magnética , Algoritmos , Cintilografia
3.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1853-1858, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018361

RESUMO

The increasing prevalence and adaptability of 3D optical scan (3DO) technology has invoked many recent studies which use 3DO scanning as a convenient and inexpensive means for predicting body composition and health risks. The Shape Up studies seek a device-agnostic solution for body composition estimation based on principal component analysis (PCA). This paper reports a progress made on Shape Up's previous work which served as a criterion analysis for PCA-based body composition and health risk prediction. This study presents proof-of-concept for a novel automated landmark detection step that allows for a fully automated PCA-based approach to body composition estimation that facilitates a practical device-agnostic PCA-based solution to body composition estimation from 3DO scans. Our results show that replacing expensive and time-consuming manual point placement with the proposed automated landmarks will not diminish the quality of body composition estimates allowing for a more practical pipeline that can be used in real-world settings.


Assuntos
Composição Corporal , Humanos , Análise de Componente Principal , Cintilografia
4.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1895-1898, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018371

RESUMO

We present a robust, precise image binarization technique for automatically detecting filamentous microorganisms from digital fluorescence microscopy scans, with application to finding the pseudohyphae that are fungal pathogens responsible for Candida vaginitis. This method employs a hybrid constant false positive rate processor that integrates cell average and order statistic detectors, with linear windows at multiple orientation angles. The hypothesis test rule incorporates elongation enhancement and region of interest masking. Our approach achieves the adaptivity to local noise and all possible object orientations. The designed processor is evaluated theoretically and experimentally using clinical images. Successful detection results are demonstrated.


Assuntos
Vaginite , Feminino , Humanos , Microscopia de Fluorescência , Cintilografia , Vaginite/diagnóstico
5.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1299-1302, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018226

RESUMO

We proposed a target-based cone beam computed tomography (CBCT) imaging framework in order to optimize a free three dimensional (3D) source-detector trajectory by incorporating prior 3D image data. We aim to enable CBCT systems to provide topical information about a region of interest (ROI) using a short-scan trajectory with a reduced number of projections. The best projection views are selected by maximizing an objective function fed by the image quality by means of applying different x-ray positions on the digital phantom data. Finally, an optimized trajectory is selected which is applied to a C-arm device able to perform general source-detector positioning. An Alderson-Rando head phantom is used in order to investigate the performance of the proposed framework. Our experiments showed that the optimized trajectory could achieve a comparable image quality in the ROI with respect to the reference C-arm CBCT while using approximately one-quarter of projections. An angular range of 156° was used for the optimized trajectory.


Assuntos
Tomografia Computadorizada de Feixe Cônico Espiral , Tomografia Computadorizada de Feixe Cônico , Imageamento Tridimensional , Imagens de Fantasmas , Cintilografia
6.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1319-1322, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018231

RESUMO

Metal artifacts are very common in CT scans since metal insertion or replacement is performed for enhancing certain functionality or mechanism of patient's body. These streak artifacts could degrade CT image quality severely, and consequently, they could influence clinician's diagnosis. Many existing supervised learning methods approaching this problem assume the availability of clean images data, images free of metal artifacts, at the part with metal implant. However, in clinical practices, those clean images do not usually exist. Therefore, there is no support for the existing supervised learning based methods to work clinically. We focus on reducing the streak artifacts on the hip scans and propose a convolutional neural network based method to eliminate the need of the clean images at the implant part during model training. The idea is to use the scans of the parts near the hip for model training. Our method is able to suppress the artifacts in corrupted images, highly improve the image quality, and preserve the details of surrounding tissues, without using any clean hip scans. We apply our method on clinical CT hip scans from multiple patients and obtain artifact-free images with high image quality.


Assuntos
Artefatos , Redes Neurais de Computação , Humanos , Metais , Cintilografia , Tomografia Computadorizada por Raios X
7.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1331-1334, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018234

RESUMO

Lung cancer is the most common form of cancer found worldwide with a high mortality rate. Early detection of pulmonary nodules by screening with a low-dose computed tomography (CT) scan is crucial for its effective clinical management. Nodules which are symptomatic of malignancy occupy about 0.0125 - 0.025% of volume in a CT scan of a patient. Manual screening of all slices is a tedious task and presents a high risk of human errors. To tackle this problem we propose a computationally efficient two stage framework. In the first stage, a convolutional neural network (CNN) trained adversarially using Turing test loss segments the lung region. In the second stage, patches sampled from the segmented region are then classified to detect the presence of nodules. The proposed method is experimentally validated on the LUNA16 challenge dataset with a dice coefficient of 0.984±0.0007 for 10-fold cross-validation.


Assuntos
Interpretação de Imagem Radiográfica Assistida por Computador , Tomografia Computadorizada por Raios X , Humanos , Pulmão/diagnóstico por imagem , Redes Neurais de Computação , Cintilografia
8.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1481-1484, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018271

RESUMO

Long scan duration remains a challenge for high-resolution MRI. Deep learning has emerged as a powerful means for accelerated MRI reconstruction by providing data-driven regularizers that are directly learned from data. These data-driven priors typically remain unchanged for future data in the testing phase once they are learned during training. In this study, we propose to use a transfer learning approach to fine-tune these regularizers for new subjects using a self-supervision approach. While the proposed approach can compromise the extremely fast reconstruction time of deep learning MRI methods, our results on knee MRI indicate that such adaptation can substantially reduce the remaining artifacts in reconstructed images. In addition, the proposed approach has the potential to reduce the risks of generalization to rare pathological conditions, which may be unavailable in the training data.


Assuntos
Algoritmos , Redes Neurais de Computação , Imagem por Ressonância Magnética , Física , Cintilografia
9.
Anticancer Res ; 40(10): 5735-5738, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32988899

RESUMO

BACKGROUND/AIM: Surgical staging is paramount to treatment of primary bone sarcomas. Often, bone scintigraphy and/or positron emission tomography-computed tomography (PET-CT) are used to exclude skeletal metastases; however, skeletal metastases in chondrosarcoma are rare. The purpose of this study was to assess the utility of these staging methods in patients with chondrosarcoma. PATIENTS AND METHODS: We reviewed 138 (87 males, 51 female) patients, mean age 54±20 years, with a chondrosarcoma, who had completed a bone scintigraphy or PET/CT as part of surgical staging. Sensitivity, specificity, and positive/negative predictive value of the scans was calculated. RESULTS: Seventeen (12%) patients had a positive bone scintigraphy or PET-CT for skeletal metastases. In cases of bone scintigraphy (n=11), 6 were benign and 5 were skeletal metastases. In cases of PET-CT, 6 were skeletal metastases, 3 were positive and 3 benign. All positive cases regarded dedifferentiated chondrosarcoma. The overall sensitivity and specificity of a bone scan or PET-CT was 100% and 93.1%; with a positive and negative predictive value of 47.1% and 100%, respectively. CONCLUSION: Skeletal metastases at presentation of chondrosarcoma are rare and associated with dedifferentiated chondrosarcoma. Bone scintigraphy or PET-CT should only be performed in cases of high grade and dedifferentiated histology.


Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Condrossarcoma/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Cintilografia , Neoplasias Ósseas/patologia , Neoplasias Ósseas/secundário , Osso e Ossos/diagnóstico por imagem , Osso e Ossos/patologia , Condrossarcoma/patologia , Feminino , Fluordesoxiglucose F18/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Tomografia Computadorizada por Raios X
10.
Medicine (Baltimore) ; 99(36): e22038, 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32899061

RESUMO

The effectiveness of diethylenetriamine pentaacetic acid scan is regularly monitored for the assessment of any potential modifications in treatment responses or kidney functions in the pediatric population.This study attempts to compare the usefulness of diethylenetriamine pentaacetic acid and ultrasound imaging of renal disorders among paediatric patients.A retrospective observational study was conducted by enrolling 106 children. The demographic details such as: participant's age, gender, and the history of renal disease of each patient were recorded. Patients were administered radiopharmaceuticals in a fixed dose and were later subjected to computed tomography (CT) scan. The obtained data was analysed using descriptive statistics.Findings indicated increased sensitivity for CT (61.20%); whereas, a major decrease in specificity (23.68%) was observed. Comparison of Single-photon emission CT (SPECT) and CT findings revealed the increased sensitivity (90.90%) for ultrasound; whereas, there was a slight decrease in the specificity (40%) for SPECT. However, SPECT findings show 91% sensitivity among patients with 71.42% positive predictive value. Moreover, an increase in sensitivity for CT (61.20%), followed by a major decrease in specificity (23.68%) was observed.Ultrasonography has been proved to be the safest and the most effective method for the diagnosis and the treatment of most renal disorders, due to the higher predictive value of SPECT scans. It is thus suggested that patients with ureteral calculi should be diagnosed with renal scintigraphy and unenhanced helical computerized tomography.


Assuntos
Nefropatias/diagnóstico por imagem , Ácido Pentético/administração & dosagem , Cintilografia/métodos , Ultrassonografia/métodos , Cálculos Ureterais/diagnóstico por imagem , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Nefropatias/fisiopatologia , Masculino , Medicina Nuclear/métodos , Valor Preditivo dos Testes , Compostos Radiofarmacêuticos/administração & dosagem , Estudos Retrospectivos , Sensibilidade e Especificidade , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Tomografia Computadorizada por Raios X/métodos
11.
Hell J Nucl Med ; 23 Suppl: 21-25, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32860392

RESUMO

On December 29, 2019, a hospital in the City of Wuhan, Hubei Province, in Central China, admitted four individuals with pneumonia. The hospital reported this occurrence to the local center for disease control (CDC), which lead Wuhan CDC staff to initiate a field investigation with a retrospective search for pneumonia patients. On December 31, 2019, the World Health Organization (WHO) was alerted by the Chinese authorities for several cases of pneumonia of unknown origin in the City of Wuhan. On January 7, 2020, a novel virus was identified as the causative agent, belonging to the Coronaviridae family (Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2). Within the same month, the virus spread to other provinces of China, as well as a number of neighbouring countries. On February 11, 2020, the WHO announced that the SARS-CoV-2 - caused infection would be called coronavirus disease 2019 (COVID-19). On February 15, 2020, the first death due to COVID-19 in Europe was reported; a Chinese tourist who died in France. The first COVID-19 case was diagnosed in Greece on February 26th. The WHO declared COVID-19 a pandemic on 11 March 2020. On March 12th, movie theaters, gyms and courtrooms were closed in Greece and on March 13th, with 190 confirmed cases and 1 death, malls, cafés, restaurants, bars, beauty parlors, museums and archaeological sites were also closed. So far, COVID-19 pandemic has affected the way people live and work globally, and has resulted in extreme strain on the healthcare systems worldwide. Most of the nuclear medicine studies are performed on an out-patient basis. Therefore, without effective implementation of the required preventive measures, there is a significant risk for viral transmission when visiting nuclear medicine departments, particularly in periods of high community spread.


Assuntos
Infecções por Coronavirus/transmissão , Controle de Infecções/métodos , Serviço Hospitalar de Medicina Nuclear/normas , Pneumonia Viral/transmissão , Guias de Prática Clínica como Assunto , Cintilografia/normas , Infecções por Coronavirus/epidemiologia , Prioridades em Saúde , Humanos , Controle de Infecções/normas , Pneumopatias/diagnóstico por imagem , Neoplasias/diagnóstico por imagem , Serviço Hospitalar de Medicina Nuclear/organização & administração , Pandemias , Pneumonia Viral/epidemiologia , Cintilografia/métodos
12.
Hell J Nucl Med ; 23 Suppl: 57-64, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32862216

RESUMO

The novel coronavirus disease 2019 (COVID-19) pandemic has changed people's normal lives in a very short time causing extensive infections and mortality, which required the national health systems to be adapted to new situation. Changes in healthcare services included modifications of standard procedures in nuclear medicine departments in order to limit COVID-19 spreading and protect patients and personnel. Here, we recommend management of patients with neurological diseases and especially dementia and movement disorders, who are referred for neuroimaging with nuclear medicine techniques.


Assuntos
Infecções por Coronavirus/transmissão , Controle de Infecções/métodos , Doenças do Sistema Nervoso/diagnóstico por imagem , Pneumonia Viral/transmissão , Guias de Prática Clínica como Assunto , Serviço Hospitalar de Radiologia/normas , Cintilografia/métodos , Infecções por Coronavirus/epidemiologia , Humanos , Controle de Infecções/normas , Pandemias , Pneumonia Viral/epidemiologia , Cintilografia/normas
13.
Internist (Berl) ; 61(9): 964-968, 2020 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-32734334

RESUMO

BACKGROUND: We report the case of a 46-year-old female patient who presented in the emergency department with intermittent disturbances of perception when fasting. DIAGNOSTICS: In the diagnostic fasting test, a hyperinsulinemic hypoglycemia already occurred after 7h. A sonographic examination was inconspicuous, therefore, a Ga 68-HA-DOTATATE positron emission tomography computed tomography (PET-CT) was carried out. The results were indicative of a neuroendocrine neoplasm, which gave rise to the suspicion of an insulinoma. CLINICAL COURSE: For surgical treatment the patient was transferred to an external hospital. Following surgery, the patient was free of symptoms. CONCLUSION: If multiple symptoms of hypoglycemia are present, an insulinoma as the cause must be considered in the differential diagnostics.


Assuntos
Jejum/efeitos adversos , Hipoglicemia/diagnóstico , Hipoglicemia/etiologia , Insulinoma/complicações , Insulinoma/diagnóstico por imagem , Tumores Neuroendócrinos/diagnóstico por imagem , Neoplasias Pancreáticas/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos , Feminino , Humanos , Pessoa de Meia-Idade , Tumores Neuroendócrinos/patologia , Tumores Neuroendócrinos/cirurgia , Compostos Organometálicos , Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/cirurgia , Tomografia por Emissão de Pósitrons , Cintilografia
14.
Artigo em Japonês | MEDLINE | ID: mdl-32814733

RESUMO

The purpose of this study was to investigate the trends of researches regarding radiological technology. We collected research papers published from 2007 to 2017 from Japanese Society of Radiological Technology (JSRT). After preprocessing, we performed morphological analysis using terminology from Japan Radiological Society, Japan Society of Medical Physics, and JSRT to extract technical terms. Furthermore, we calculated the Jaccard similarity coefficient to represent the similarity between two terms. This value ranged from 0 to 1, where 0 implied that the terms were completely dissimilar. Finally, in order to detect terms that characteristically appear in each year, we visualized co-occurring terms by using network diagrams. From the morphological analysis, 5471 technical terms were extracted. The most frequency term was "image" from 2007 to 2017. "Phantom" and "CT" were frequent terms after "image." In addition, the number of research papers including "image," "phantom," and "CT" were increasing. For network analysis, the characteristic terms in 2007 were "filter" and "HU"; those in 2012 were "dimension," "standard deviation,"and "artifact"; and those in 2017 were "PET," "scattered ray," and "collimator." In conclusion, the highest interest research topic in radiological technology was "image," and recently, there has been a tendency to be interested in topics related to nuclear medicine.


Assuntos
Mineração de Dados , Tecnologia Radiológica , Japão , Imagens de Fantasmas , Cintilografia
15.
PLoS One ; 15(8): e0237213, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32797099

RESUMO

Bone metastasis is one of the most frequent diseases in prostate cancer; scintigraphy imaging is particularly important for the clinical diagnosis of bone metastasis. Up to date, minimal research has been conducted regarding the application of machine learning with emphasis on modern efficient convolutional neural networks (CNNs) algorithms, for the diagnosis of prostate cancer metastasis from bone scintigraphy images. The advantageous and outstanding capabilities of deep learning, machine learning's groundbreaking technological advancement, have not yet been fully investigated regarding their application in computer-aided diagnosis systems in the field of medical image analysis, such as the problem of bone metastasis classification in whole-body scans. In particular, CNNs are gaining great attention due to their ability to recognize complex visual patterns, in the same way as human perception operates. Considering all these new enhancements in the field of deep learning, a set of simpler, faster and more accurate CNN architectures, designed for classification of metastatic prostate cancer in bones, is explored. This research study has a two-fold goal: to create and also demonstrate a set of simple but robust CNN models for automatic classification of whole-body scans in two categories, malignant (bone metastasis) or healthy, using solely the scans at the input level. Through a meticulous exploration of CNN hyper-parameter selection and fine-tuning, the best architecture is selected with respect to classification accuracy. Thus a CNN model with improved classification capabilities for bone metastasis diagnosis is produced, using bone scans from prostate cancer patients. The achieved classification testing accuracy is 97.38%, whereas the average sensitivity is approximately 95.8%. Finally, the best-performing CNN method is compared to other popular and well-known CNN architectures used for medical imaging, like VGG16, ResNet50, GoogleNet and MobileNet. The classification results show that the proposed CNN-based approach outperforms the popular CNN methods in nuclear medicine for metastatic prostate cancer diagnosis in bones.


Assuntos
Neoplasias Ósseas/secundário , Redes Neurais de Computação , Neoplasias da Próstata/patologia , Imagem Corporal Total/métodos , Neoplasias Ósseas/classificação , Neoplasias Ósseas/diagnóstico por imagem , Diagnóstico por Computador/métodos , Humanos , Interpretação de Imagem Assistida por Computador/métodos , Aprendizado de Máquina , Masculino , Cintilografia/métodos , Software
16.
Medicine (Baltimore) ; 99(32): e21029, 2020 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-32769864

RESUMO

A pleuroperitoneal leak (PPL) is a relatively rare complication of peritoneal dialysis (PD) and early diagnosis is essential.Patients suspected of a PPL usually present with dyspnea (marked during inflow of PD fluid) and tend to have transudative high glucose pleural effusions.The PPL scintigraphy (PPLS) is one of the methods for objectively proving a PPL. The effectiveness of PPLS as a noninvasive method of evaluating a suspected PPL and its effectiveness in the exclusion of a leak in patients with similarly presenting comorbidities was assessed.Patients suspected to have a PPL were considered for PPLS based on clinical presentation and pleural fluid analysis. Radiopharmaceutical was administered into the peritoneum via the dialysis port with the patient lying supine and immediate dynamic followed by delayed statics were acquired.Of the 27 scans reviewed, 70% were found to be positive with majority detected within 12 minutes of radiopharmaceutical administration with a high predominance occurring in the right chest (P < .001). In PPLS-positive patients, when both chest X-rays and planar agreed on showing the right-sided chest predominance, the highest measurements of the pleural glucose:serum glucose ratio were recorded. A statistically significant correlation between the outcome of the scan and final decision on patient management was noted (P < .01).The PPLS is an effective diagnostic tool for assessing PPLS. However, multicenter studies investigating its added value over other conventional methods are needed to establish it as a highly relevant diagnostic tool.


Assuntos
Falência Renal Crônica/diagnóstico por imagem , Falência Renal Crônica/terapia , Diálise Peritoneal/efeitos adversos , Derrame Pleural/diagnóstico por imagem , Derrame Pleural/etiologia , Cintilografia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Radiografia , Estudos Retrospectivos , Adulto Jovem
17.
Medicine (Baltimore) ; 99(27): e21102, 2020 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-32629743

RESUMO

RATIONALE: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare disease without standard treatments. Tripterygium wilfordii hook f (TwHF) is a traditional Chinese herb with anti-inflammatory effect, and 1.0 mg/(kg·d) dose of Tripterygium glycosides has been reported to significantly improve the disease activity of a SAPHO patient in a case report. However, the optimal dose of TwHF is still unclear. Here, we report the first case of SAPHO patient who achieved rapid remission in clinical symptoms after receiving 1.5 mg/(kg·d) dose of Tripterygium glycosides treatment. PATIENT CONCERNS: A 67-year-old woman noted palmoplantar pustulosis and pain in the anterior chest wall and waist. Bone scintigraphy demonstrated the typical tracer accumulation feature and magnetic resonance images showed bone marrow edema in lumbosacral vertebra. DIAGNOSES: The diagnosis was made by dermatological and osteoarticular manifestations and classical signs in bone scintigraphy in accordance with the diagnostic criteria proposed in 2012. INTERVENTIONS: Tripterygium glycosides was given with a primary dose of 1.5 mg/(kg·d) for 1 month and then reduced at a rate of 10 mg every 2 weeks until 1.0 mg/(kg·d) for a long-term maintenance. OUTCOMES: Fast-induced remission on clinical manifestations was achieved and magnetic resonance imaging abnormality was improved significantly. Additionally, no apparent side effects were observed. LESSONS: 1.5 mg/(kg·d) dose of Tripterygium glycosides seems to have fast-induced remission than 1.0 mg/(kg·d) with reliable safety. Besides, Tripterygium glycosides may also have a pharmacological effect of inhibiting osteolysis and enhancing bone strength.


Assuntos
Síndrome de Hiperostose Adquirida/tratamento farmacológico , Osso e Ossos/patologia , Medicamentos de Ervas Chinesas/uso terapêutico , Glicosídeos/uso terapêutico , Síndrome de Hiperostose Adquirida/patologia , Idoso , Osso e Ossos/diagnóstico por imagem , Osso e Ossos/efeitos dos fármacos , Medicamentos de Ervas Chinesas/administração & dosagem , Feminino , Glicosídeos/administração & dosagem , Humanos , Região Lombossacral/diagnóstico por imagem , Região Lombossacral/patologia , Imagem por Ressonância Magnética/métodos , Osteólise/prevenção & controle , Psoríase/etiologia , Cintilografia/métodos , Indução de Remissão , Resultado do Tratamento , Tripterygium
18.
Acad Radiol ; 27(9): 1204-1213, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32665091

RESUMO

RATIONALE AND OBJECTIVES: Predictive models and anecdotal articles suggest radiology practices were losing 50%-70% of their normal imaging volume during the COVID-19 pandemic. Using actual institutional data, we investigated the change in imaging utilization and revenue during this public health crisis. MATERIALS AND METHODS: Imaging performed within the 8-week span between March 8 and April 30, 2020 was categorized into the COVID-19 healthcare crisis timeframe. The first week of this date range and the 10 weeks prior were used to derive the normal practice expected volume. A rolling 7-day total value was used for volume tracking and comparison. Total imaging utilization was derived and organized by patient setting (outpatient, inpatient, emergency) and imaging modality (X-ray, CT, Mammography, MRI, Nuclear Medicine/PET, US). The three highest volume hospitals were analyzed. Revenue information was collected from the hospital billing system. RESULTS: System-wide imaging volume decreased by 55% between April 7 and 13, 2020. Outpatient exams decreased by 68% relative to normal practice. Emergency exams decreased by 48% and inpatient exams declined by 31%. Mammograms and nuclear medicine scans were the most affected modalities, decreasing by 93% and 61%, respectively. The main campus hospital experienced less relative imaging volume loss compared to the other smaller and outpatient-driven hospitals. At its lowest point, the technical component revenue from main campus imaging services demonstrated a 49% negative variance from normal practice. CONCLUSION: The trends and magnitude of the actual imaging utilization data presented will help inform evidence-based decisions for more accurate volume predictions, policy changes, and institutional preparedness for current and future pandemics.


Assuntos
Betacoronavirus , Infecções por Coronavirus/diagnóstico por imagem , Pneumonia Viral/diagnóstico por imagem , Serviço Hospitalar de Emergência , Humanos , Imagem por Ressonância Magnética , Pandemias , Serviço Hospitalar de Radiologia , Cintilografia
20.
Eur J Vasc Endovasc Surg ; 60(3): 395-401, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32665199

RESUMO

OBJECTIVE: The objective of this prospective single centre study was to assess whether branches and fenestrations have different outcomes on renal function in the early phase. METHODS: From March 2018 to June 2019, 67 patients who underwent elective fenestrated and branched endovascular aneurysm repair (F/BEVAR) procedures were enrolled in this study. The patients were divided into two groups according to the renal bridging component configuration (fenestration vs. branch). All of them underwent dynamic renal scintigraphy with 99mTc diethylenetriaminepentaacetic acid (DTPA), two weeks pre-operatively, and three months and one year post-operatively. The primary end points were peri-procedural technical success, 30 day major adverse events, differences in glomerular filtration rate (GFR) between the branch and fenestration configurations, and variations between the pre-operative and the post-operative dynamic renal scintigraphy. RESULTS: Overall, 135 kidneys were analysed: 63 in the 32 patients treated with fenestrations, and 72 in the 35 patients treated with branches; the mean GFR on baseline scintigraphy was 58.4 ± 30.9 mL/min in the fenestration group, and 65.1 ± 29.2 mL/min in the branch group. Only kidneys associated with a patent fenestration/branch were included in the split GFR final analysis. The mean total GFR at three month scintigraphy decreased by 6.0 ± 2.9 mL/min in the fenestration group and by 23.4 ± 6.4 mL/min in the branch group. The split GFR decreased by 3.5 ± 0.6 mL/min in the fenestration group, and by 15.4 ± 5.4 mL/min in the branch group. The GFR decrease remained stable at one year. CONCLUSION: In this study, the use of branches for renal arteries during F/BEVAR resulted in a greater decrease in the GFR than in those patients who were treated with fenestrations alone. The scintigraphic alterations were evident at an early phase.


Assuntos
Aneurisma da Aorta Abdominal/cirurgia , Aneurisma da Aorta Torácica/cirurgia , Implante de Prótese Vascular/instrumentação , Prótese Vascular , Procedimentos Endovasculares/instrumentação , Nefropatias/diagnóstico por imagem , Cintilografia , Artéria Renal/cirurgia , Aneurisma da Aorta Abdominal/diagnóstico por imagem , Aneurisma da Aorta Abdominal/fisiopatologia , Aneurisma da Aorta Torácica/diagnóstico por imagem , Aneurisma da Aorta Torácica/fisiopatologia , Implante de Prótese Vascular/efeitos adversos , Procedimentos Endovasculares/efeitos adversos , Feminino , Taxa de Filtração Glomerular , Humanos , Nefropatias/etiologia , Nefropatias/fisiopatologia , Masculino , Valor Preditivo dos Testes , Estudos Prospectivos , Desenho de Prótese , Compostos Radiofarmacêuticos/administração & dosagem , Artéria Renal/diagnóstico por imagem , Artéria Renal/fisiopatologia , Pentetato de Tecnécio Tc 99m/administração & dosagem , Fatores de Tempo , Resultado do Tratamento
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