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1.
J Nucl Med ; 63(10): 14N, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36192330
2.
Theranostics ; 12(15): 6437-6445, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36185603

RESUMO

Rationale: This study aimed to assess the safety, efficacy, and survival of 177Lu-DOTA-EB-TATE in patients with metastatic neuroendocrine tumors (NETs). Methods: Thirty patients with metastatic NETs were prospectively enrolled and treated with 177Lu-DOTA-EB-TATE (3 intended cycles at 8 to 12-week intervals, 3.7 GBq/cycle). Treatment-related adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. The treatment response was graded according to RECIST 1.1 and PERCIST 1.0 criteria. Kaplan-Meier analysis was performed to calculate progression-free survival (PFS) and overall survival (OS). Results: Patients tolerated therapy well without acute adverse effects. During peptide receptor radionuclide therapy (PRRT), no grade 4 toxicity was observed in any of the patients; grade 3 hematotoxicity was recorded in 4 patients, including grade 3 thrombocytopenia in 4 patients (13.3%) and grade-3 anemia in 1 patient (3.3%); grade 3 hepatotoxicity was recorded in 1 (3.3%) patient, and no grade 2/3/4 nephrotoxicity was observed. On long-term follow-up, none of the patients developed grade 4 hematotoxicity or nephrotoxicity of any grade, reversible grade 3 hematotoxicity (thrombocytopenia) occurred in 1 patient. There was no incidence of leukemia or myelodysplastic syndrome for the duration of follow-up. Of 27 patients with RECIST-measurable disease, partial response and stable disease were seen in 9 and 14 patients, respectively, resulting in a response rate of 33.3% and disease control rate of 85.2%. Of 29 patients evaluable for response on 68Ga-DOTATATE PET/CT, 14 had partial response and 11 had stable disease, with a response rate of 48.3% and disease control rate of 86.2%. The follow-up period ranged from 5 to 57 months after the first 177Lu-DOTA-EB-TATE PRRT with a median follow-up of 46 months. The median PFS was 36 months, and the median OS was not reached. Ki-67 index of greater than 10% was associated with poorer PFS (P = 0.012). Conclusions: Our results suggest that PRRT with approximately 3.7 GBq 177Lu-DOTA-EB-TATE has acceptable toxicity profile and is effective in treating metastatic NET with high disease control rate. In addition, 177Lu-DOTA-EB-TATE achieved a favorable survival outcome with encouraging PFS.


Assuntos
Tumores Neuroendócrinos , Compostos Organometálicos , Trombocitopenia , Radioisótopos de Gálio , Humanos , Antígeno Ki-67 , Tumores Neuroendócrinos/patologia , Tumores Neuroendócrinos/radioterapia , Octreotida/efeitos adversos , Compostos Organometálicos/efeitos adversos , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Tomografia por Emissão de Pósitrons , Cintilografia , Receptores de Peptídeos , Somatostatina/análogos & derivados , Trombocitopenia/induzido quimicamente
3.
Contrast Media Mol Imaging ; 2022: 6587617, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36082054

RESUMO

Objective: To explore the diagnostic value for chronic kidney disease (CKD) between 640-slice computed tomography (CT) kidney scan and conventional CT scan. Methods: A total of 120 CKD patients who received kidney plain scan plus enhanced examination in the CT room of the Medical Imaging Department of our hospital from June 2019 to September 2019 were selected and randomly divided into the experimental group (n = 60) and the control group (n = 60). Patients in the control group received the conventional CT plain scan and enhanced scan, and for patients in the experimental group, CT plain scan was performed first, the range of 640-slice CT dynamic volume scan was determined, and after bolus injection of contrast agent, dynamic volume scan was performed for scanning in the cortical phase, myeloid phase, and secretory phase. The imaging quality and effective scanning dose were compared between the two modalities, and the relationship between CT values obtained from 640-slice CT scan and conventional CT scan and the renal impairment was analyzed. Results: Compared with the control group, the image quality of 640-slice CT scan conducted in the experimental group was significantly better (P < 0.05); the effective radiation doses of the experimental group and the control group were, respectively, (1.89 ± 0.32) mSv and (3.26 ± 0.47) mSv, indicating that the dose was significantly lower in the experimental group than in the control group (t = 18.664, P < 0.001), and the correlation analysis showed that the relationship between the sum of CT values in the cortical phase of both kidneys and kidney injury in the experimental group was r = 0.835, P < 0.001. Conclusion: Both 640-slice CT kidney scan and conventional CT scan can be used in the diagnosis of CKD. 640-slice CT has a lower radiation dose, better image quality, and higher application value.


Assuntos
Insuficiência Renal Crônica , Tomografia Computadorizada por Raios X , Meios de Contraste , Humanos , Rim/diagnóstico por imagem , Doses de Radiação , Cintilografia , Insuficiência Renal Crônica/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos
4.
Sci Rep ; 12(1): 15269, 2022 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-36088471

RESUMO

Emergent brain computed tomography (CT) scan allows for identification of patients presenting with acute severe neurological symptoms in whom medical and surgical interventions may be lifesaving. The aim of this study was to evaluate if time to CT from arrival at the emergency department exceeded 30 min in patients admitted with acute severe neurological symptoms. This was a retrospective register-based quality assurance study. We identified patients admitted to the emergency department with acute severe neurological symptoms between April 1st, 2016 and September 30th, 2020. Data were retrieved from the registry of acute medical team activations. We considered that time to CT from arrival at the emergency department should not exceed 30 min in more than 10% of patients. A total of 559 patients were included. Median time from arrival at the emergency department until CT scan was 24 min (IQR 16-35) in children (< 18 years), 10 min (IQR 7-17) for adults (18-59 years), and 11 min (IQR 7-16) for elders (> 60 years). This time interval exceeded 30 min for 8.2% (95% CI 6.1-10.9) of all included patients, 35.3% of children, 5.9% of adults, and 8.6% of elders. No children died within 30 days. The 30-day mortality was 21.3% (95% CI 16.4-27) in adults, and 43.9% (95% CI 38.2-49.8) in elders. Time from arrival at our emergency department until brain CT scan exceeded 30 min in 8.2% of all included patients but exceeded the defined quality aim in children and could be improved.


Assuntos
Serviço Hospitalar de Emergência , Tomografia Computadorizada por Raios X , Adulto , Idoso , Humanos , Cintilografia , Sistema de Registros , Estudos Retrospectivos , Tomografia Computadorizada por Raios X/métodos
5.
Annu Int Conf IEEE Eng Med Biol Soc ; 2022: 4864-4867, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36085844

RESUMO

A readout device for a dual-functional neural observation system is presented. The authors separately developed the reading operation of an implantable CMOS image sensor and a setup for fast-scan cyclic voltammetry and implemented them together in a microcontroller-based device. The developed imaging readout device with a size of [Formula: see text] can reach the highest reading rate of 160 fps with a 120×268 pixel image sensor. The voltammetry function was verified through an experiment using commercial carbon fiber electrodes in phosphate-buffered saline. When the imaging is sequentially operated with 400 V/s-scan rate voltammetry from -0.4 to 1.3 V, the system can operate at up to 60 fps. With this system, calcium imaging and dopamine recording in a freely behaving mouse can be achieved together in a simpler manner. This study aims to be the basis for the development of an implantable multi-functional sensor.


Assuntos
Cálcio , Imagem Óptica , Animais , Fibra de Carbono , Dopamina , Camundongos , Cintilografia
6.
Annu Int Conf IEEE Eng Med Biol Soc ; 2022: 3866-3869, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36086049

RESUMO

Optical coherence tomography (OCT) is widely used to detect retinal disorders. In this study a new methodology is proposed for automatic detection of macular pathologies in the OCT images. Our approach is based on modeling the normal and abnormal OCT images with α-stable mixture model represented by stochastic differential equations (SDE). Parameters of the model are used to detect abnormal OCT images. The α-stable mixture model is created after applying a fractional Laplacian operator to the image and Expectation-Maximization (EM) algorithm is applied to estimate its parameters. The classification of an OCT image as normal or abnormal would be done by training SVM classifier based on estimated parameters of the mixture model. This method is examined for macular abnormality detection such as AMD, DME, and MH and achieve maximum accuracy of 97.8%. Clinical Relevance - This study establishes automatic method for anomaly detection on OCT images and provides fast and accurate OCT interpretation in clinical application.


Assuntos
Doenças Retinianas , Tomografia de Coerência Óptica , Algoritmos , Humanos , Cintilografia , Retina/diagnóstico por imagem , Doenças Retinianas/diagnóstico por imagem , Tomografia de Coerência Óptica/métodos
7.
Annu Int Conf IEEE Eng Med Biol Soc ; 2022: 2037-2040, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36086366

RESUMO

Lung cancer is the leading cause of cancer death worldwide. Early low-dose computed tomography (CT) screening can decrease its mortality rate and computer-aided diagnoses systems may make these screenings more accessible. Radiomic features and supervised machine learning have traditionally been employed in these systems. Contrary to supervised methods, unsupervised learning techniques do not require large amounts of annotated data which are labor-intensive to gather and long training times. Therefore, recent approaches have used unsupervised methods, such as clustering, to improve the performance of supervised models. However, an analysis of purely unsupervised methods for malignancy prediction of lung nodules from CT images has not been performed. This work studies nodule malignancy in the LIDC-IDRI image collection of chest CT scans using established radiomic features and unsupervised learning methods based on k-Means, Spectral Clustering, and Gaussian Mixture clustering. All tested methods resulted in clusters of high homogeneity malignancy. Results suggest convex feature distributions and well-separated feature subspaces associated with different diagnoses. Furthermore, diagnosis uncertainty may be explained by common characteristics captured by radiomic features. The k-Means and Gaussian Mixture models are able to generalize to unseen data, achieving a balanced accuracy of 87.23% and 86.96% when inference was tested. These results motivate the usage of unsupervised approaches for malignancy prediction of lung nodules, such as cluster-then-label models. Clinical Relevance- Unsupervised clustering of radiomic features of lung nodules in chest CT scans can differentiate between malignant and benign cases and reflects experts' diagnosis uncertainty.


Assuntos
Neoplasias Pulmonares , Lesões Pré-Cancerosas , Humanos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Cintilografia , Tomografia Computadorizada por Raios X/métodos
8.
Gan To Kagaku Ryoho ; 49(8): 813-820, 2022 Aug.
Artigo em Japonês | MEDLINE | ID: mdl-36046962

RESUMO

Peptide receptor radionuclide therapy(PRRT)is a pioneer drug in the rapid development of radio-theranostics, and a paradigm-shifting approach to treat neuroendocrine tumor( NET). The NETTER-1 trial for NETs of the midgut is currently the only global phase Ⅲ prospective clinical trial demonstrating the efficacy and safety of PRRT. In Japan, phase Ⅰ and Ⅰ/Ⅱ trials for lung and gastroenteropancreatic NETs were also conducted, and regulatory approval was granted in June of 2021. Although regulatory approval was obtained in Japan without specifying the primary organ or the history of treatment, there is limited evidence at this time, and guidelines recommend use after the second-line for midgut NETs and in the last phase for all other NETs. PRRT is expected to be utilized as upfront therapy, and the results of ongoing prospective clinical trials are awaited. The effect of PRRT is corelated with accumulation rate of somatostatin receptor scintigraphy(SRS). Sometime accumulation rate of SRS is not constant among multiple tumors in even one patient, then effective use of PRRT is depending on detailed exploration for result of SRS of each tumor. In order to perform this treatment in Japan, a special ward dedicated to radionuclide therapy or at least" a special measures patient room" prescribed by laws and regulations is necessary." A special measures patient room" is a general patient room with temporary isolation and taking radiation protection countermeasure, instead of the special exhaust and drainage systems of radionuclide therapy ward. On the other hand, in order to operate the rooms, it is necessary to set up and decontaminate the rooms for each treatment, which requires specialized knowledge and manpower. Since there is a growing demand for radionuclide therapies, it is important to promote the appropriate introduction of this therapy and to establish a collaborative network for this purpose.


Assuntos
Tumores Neuroendócrinos , Compostos Organometálicos , Ensaios Clínicos como Assunto , Humanos , Japão , Tumores Neuroendócrinos/tratamento farmacológico , Octreotida/uso terapêutico , Compostos Organometálicos/uso terapêutico , Tomografia por Emissão de Pósitrons , Estudos Prospectivos , Radioisótopos/uso terapêutico , Cintilografia
9.
Clin Nucl Med ; 47(10): 916-917, 2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-36067087

RESUMO

ABSTRACT: A 67-year-old woman complained of continuous low back pain for 4 months. She was referred for a 99mTc-MIBI parathyroid scintigraphy with neck SPECT/CT imaging. The planar images showed no abnormal uptake. However, on the SPECT/CT scan, a soft tissue nodule with high uptake was noted adjacent to the left submandibular gland, mimicking normal submandibular gland uptake. Pathological examination from surgical specimen showed that it was an ectopic parathyroid adenoma.


Assuntos
Adenoma , Neoplasias das Paratireoides , Adenoma/diagnóstico por imagem , Adenoma/cirurgia , Idoso , Feminino , Humanos , Glândulas Paratireoides/diagnóstico por imagem , Neoplasias das Paratireoides/diagnóstico por imagem , Neoplasias das Paratireoides/cirurgia , Cintilografia , Glândula Submandibular , Tecnécio Tc 99m Sestamibi
10.
Clin Nucl Med ; 47(10): e627-e629, 2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-36067088

RESUMO

ABSTRACT: A 73-year-old woman with metastatic breast cancer and known widespread skeletal metastases was referred for bone scintigraphy. Delayed images acquired at 2 and 5 hours postinjection of 30 mCi (1089 MBq) 99mTc-HDP demonstrated markedly reduced bony uptake, markedly increased renal activity, and significantly increased soft tissue accumulation. By contrast, appropriate skeletal uptake of 99mTc-HDP was seen in prior bone scans. The patient had been treated for iron deficiency anemia with an infusion of 1 g of iron polymaltose approximately 22 hours before injection of 99mTc-HDP. This phenomenon may be due to transient reduced bone resorption with increased FGF23 release secondary to IV iron supplementation.


Assuntos
Neoplasias Ósseas , Neoplasias da Mama , Idoso , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/secundário , Feminino , Compostos Férricos , Humanos , Cintilografia , Tomografia Computadorizada por Raios X
11.
Nucl Med Rev Cent East Eur ; 25(2): 138-140, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36047293

RESUMO

BACKGROUND: Thyroid cancer is the most common malignant disease of the endocrine system and radioiodine therapy (RAIT) is still very often used, resulting in patients staying hospitalized for a few days alone and without visitors, augmenting their stress and discomfort. Our objective was to find simple ways of improving RAIT patients' feelings and perceived quality of the nuclear medicine (NM) department services. MATERIAL AND METHODS: We designed a two-year study in order to enhance RAIT patients' perceived quality of the nuclear medicine (NM) department services and expectations' fulfillment. A questionnaire was used in order to capture patients' perceived quality and expectations from their RAIT. RESULTS: 549 replies were collected. Many intrinsic and extrinsic determinants were found to be positively or negatively related to the perceived quality and fulfillment of patients' expectations of receiving RAIT. A 1% increase could be achieved by spending 110 € per RAIT room. CONCLUSIONS: In this article, we present some easily implemented changes in both personnel behavior and room amenities that could, at least in theory and based on our results, offer a 37.9% improvement in RAIT patients' perceived quality and expectations' fulfillment at a cost of 4169 €.


Assuntos
Radioisótopos do Iodo , Neoplasias da Glândula Tireoide , Humanos , Radioisótopos do Iodo/uso terapêutico , Motivação , Cintilografia , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/radioterapia
12.
Nucl Med Rev Cent East Eur ; 25(2): 89-94, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36047295

RESUMO

BACKGROUND: Accurate preoperative localisation of the parathyroid adenoma is essential to achieve a minimally invasive parathyroidectomy. The purpose of this study was to validate and improve our single-isotope dual-phase parathyroid imaging protocol utilising 99mTechnetium-Sestamibi ([99mTc]MIBI). There has been no accepted gold standard evidence-based protocol regarding timing of single-photon emission computed tomography/computed tomography (SPECT/CT) acquisition in parathyroid imaging with resultant variation between centres. We sought to determine the optimum timing of SPECT/CT post administration of [99mTc]MIBI in the identification of parathyroid adenomas. We aimed to evaluate the efficacy of early and late SPECT/CT and to establish whether SPECT/CT demonstrates increased sensitivity over planar imaging. MATERIAL AND METHODS: A sample of 36 patients with primary hyperparathyroidism underwent planar and SPECT/CT acquisition 15 minutes (early) and two hours (late) post [99mTc]MIBI administration. Two radionuclide radiologists reviewed the images and Fisher's exact Chi-squared statistic was used to evaluate the diagnostic performances of early versus late SPECT/CT acquisition and SPECT/CT versus planar imaging. RESULTS: Twenty-one likely parathyroid adenomas were identified with a statistically superior diagnosis rate in the late SPECT/CT acquisition compared with both early SPECT/CT and planar imaging (p < 0.05). All adenomas diagnosed on early SPECT/CT acquisition were also identified on late SPECT/CT images. CONCLUSIONS: Single late phase SPECT/CT is significantly superior to early SPECT/CT in the identification of parathyroid adenomas. Late SPECT/CT improves diagnostic accuracy over planar acquisition. Imaging protocols should be revised to include late SPECT/CT acquisition. Early SPECT/CT acquisition can be eliminated from scan protocols with associated implications regarding reduced scan time and increased patient throughput.


Assuntos
Neoplasias das Paratireoides , Tecnécio Tc 99m Sestamibi , Humanos , Glândulas Paratireoides , Neoplasias das Paratireoides/complicações , Neoplasias das Paratireoides/diagnóstico por imagem , Cintilografia , Compostos Radiofarmacêuticos , Sensibilidade e Especificidade , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Tomografia Computadorizada por Raios X/métodos
13.
Nucl Med Rev Cent East Eur ; 25(2): 131-133, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36047299

RESUMO

A 2-month-old infant was referred for hepatobiliary scintigraphy due to ascites of unknown cause. The top differential diagnosis was spontaneous perforation of the biliary ducts. Delayed images up to 4 hours were against this diagnosis showing normal distribution of the radiotracer throughout the bowel. However, on delayed images, the scan showed mild tracer retention in the ascites confirmed by SPECT/CT images. Surprisingly, the exploratory abdominal surgery revealed an intact hepatobiliary system, pointing toward other possible etiologies. Second-review surgery was performed due to uncontrolled progressive ascites showing congestive hepatopathy and biliary leak from the hepatic surface suggestive of the "crying liver".


Assuntos
Choro , Perfuração Espontânea , Ascite , Humanos , Lactente , Fígado/diagnóstico por imagem , Cintilografia
14.
Biomed Res Int ; 2022: 3125426, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36060133

RESUMO

Objectives: To investigate a deep learning reconstruction algorithm to reduce the time of synthetic MRI (SynMRI) scanning on the breast and improve the image quality. Materials and Methods: A total of 192 healthy female volunteers (mean age: 48.1 years) underwent the breast MR examination at 3.0 T from September 2020 to June 2021. Standard SynMRI and fast SynMRI scans were collected simultaneously on the same volunteer. Deep learning technology with a generative adversarial network (GAN) was used to generate high-quality fast SynMRI images by end-to-end training. Peak signal-to-noise ratio (PSNR), mean squared error (MSE), and structural similarity index measure (SSIM) were used to compare the image quality of generated images from fast SynMRI by deep learning algorithms. Results: Fast SynMRI acquisition time is half of the standard SynMRI scan, and the generated images of the GAN model show that PSNR and SSIM are improved and MSE is reduced. Conclusion: The application of deep learning algorithms with GAN model in breast MAGiC MRI improves the image quality and reduces the scanning time.


Assuntos
Aprendizado Profundo , Algoritmos , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Pessoa de Meia-Idade , Cintilografia , Razão Sinal-Ruído
15.
Sci Rep ; 12(1): 16299, 2022 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-36175526

RESUMO

After new drugs enter the market, adverse events (AE) induced by their use must be tracked; rare AEs may not be detected during clinical trials. Some organizations have been collecting information on suspected drugs and AEs via a spontaneous reporting system to conduct post-market drug safety surveillance. These organizations use the information to detect a signal representing potential causality between drugs and AEs. The drug and AE data are often hierarchically structured. Accordingly, the tree-based scan statistic can be used as a statistical data mining method for signal detection. Most of the AE databases contain a large number of zero-count cells. Notably, not only an observational zero from the Poisson distribution, but also a true zero exists in zero-count cells. True zeros represent theoretically impossible observations or possible but unreported observations. The existing tree-based scan statistic assumes that all zeros are zero-valued observations from the Poisson distribution. Therefore, true zeros are not considered in the modeling, which can lead to bias in the inferences. In this study, we propose a tree-based scan statistic for zero-inflated count data in a hierarchical structure. According to our simulation study, in the presence of excess zeros, our proposed tree-based scan statistic provides better performance than the existing tree-based scan statistic. The two methods were illustrated using Korea Adverse Event Reporting System data from the Korea Institute of Drug Safety and Risk Management.


Assuntos
Insuflação , Academias e Institutos , Simulação por Computador , Mineração de Dados , Cintilografia
16.
Curr Opin Endocrinol Diabetes Obes ; 29(5): 456-465, 2022 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-36068937

RESUMO

PURPOSE OF REVIEW: Thyroid cancers are endocrine neoplasms with diverse gene expression and behavior, for which constantly evolving anatomic and functional imaging/theranostic agents have an essential role for diagnosis, staging, and treatment. RECENT FINDINGS: To achieve definitive diagnosis, neck ultrasound and associated risk stratification systems, notably Thyroid Imaging Reporting and Data System (TI-RADS), allow improved thyroid nodule characterization and management guidance. Radioactive iodine-131 (RAI) has long played a role in management of differentiated thyroid cancer (DTC), with recent literature emphasizing its effectiveness for intermediate-high risk cancers, exploring use of dosimetry for personalized medicine, and potential for retreatment with RAI following tumor redifferentiation. Iodine-124 positron emission tomography/computed tomography (PET/CT) has promising application for DTC staging and dosimetry. F18-fluorodeoxyglucose (FDG) PET/CT is used for staging of high risk DTC and identification of noniodine-avid disease recurrences, with metabolic uptake consistently portending poor prognosis. Poorly differentiated and anaplastic thyroid cancers are best assessed with anatomic imaging and F18-FDG PET/ CT, though recent studies show a potential theranostic role for Ga68/Lu177-prostate-specific membrane antigen. Medullary thyroid cancers are evaluated with ultrasound, CT, magnetic resonance imaging, and various positron-emitting radiotracers for PET imaging (F18-DOPA, F18-FDG, and recently Ga68-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-octreotate (DOTATATE)); the latter may enable treatment with Lu177-DOTATATE. SUMMARY: Multidisciplinary collaboration is essential to streamline appropriate management, given the wide array of available imaging and new therapies for metabolic and genetically complex cancers.


Assuntos
Radioisótopos do Iodo , Neoplasias da Glândula Tireoide , Fluordesoxiglucose F18 , Humanos , Radioisótopos do Iodo/uso terapêutico , Masculino , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Tomografia por Emissão de Pósitrons , Medicina de Precisão , Cintilografia , Compostos Radiofarmacêuticos/uso terapêutico , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/terapia
20.
Eur Rev Med Pharmacol Sci ; 26(17): 6300-6309, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36111931

RESUMO

OBJECTIVE: Esophageal motility is regulated both by coordinated stimulation and inhibition of the circular and longitudinal muscle layers of the esophagus. Although there are many diseases known to have an effect on esophageal motility, the effect of subepithelial lesions (SELs) of the esophagus on esophageal motility, which is often detected incidentally, remains still unclear. The aim of this study is to reveal the effect of SELs of the esophagus on esophageal motility evaluating it by high-resolution manometry (HRM). PATIENTS AND METHODS: A total of 32 patients with SELs in the esophagus and 12 healthy individuals were included. All patients and controls included in the study underwent HRM using a Unisensor UniTip High Resolution catheter (Laborie, Amsterdam, Netherlands) and endosonographic examination. RESULTS: The mean age was 52.60±15.56 years (range: 23-79) and the average body mass index (BMI) was 26.63±4.71 kg/m2. Gender, height, weight, and BMI measurements, smoking status, alcohol use, and DM status did not statistically differ significantly between the groups (p>0.05). Of 32 patients with SELs, 65.6% (n=21) had lesions originating in the muscularis propria, while 34.4% had lesions originating in the submucosa. The rate of abnormal motility both in the supine and in upright positions of patients with SELs was found to be significantly higher than in the control group (p=0.001, p<0.01, respectively). In patients with SELs, the incidence of infective motility was higher than the normal group (p=0.001, p<0.01, respectively). As the size of the lesion increases (>2 cm), the probability of abnormal HRM results increased. CONCLUSIONS: SELs of the esophagus have pathological effects on esophageal motility, mainly ineffective esophageal motility disorder.


Assuntos
Transtornos da Motilidade Esofágica , Adulto , Idoso , Endossonografia , Transtornos da Motilidade Esofágica/diagnóstico por imagem , Humanos , Manometria/métodos , Pessoa de Meia-Idade , Cintilografia
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