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1.
Am J Case Rep ; 22: e930911, 2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34489391

RESUMO

BACKGROUND Ureteroinguinal hernias are exceptionally rare and are seldom diagnosed in the preoperative setting. There are 2 classifications of this type of hernia: paraperitoneal and extraperitoneal. CASE REPORT We report a case of a 67-year-old man who presented with urinary symptoms and a reducible right inguinal hernia. A computed tomography (CT) scan of the abdomen and pelvis suggested an ureteroinguinal hernia. Further diagnostics and treatment via cystoscopy, retrograde pyelogram, and right ureteral stent placement were performed, confirming the diagnosis and providing relief of the obstructive uropathy. The patient underwent an attempted elective transabdominal preperitoneal repair that was converted to an open Lichtenstein repair. Intraoperatively, an extraperitoneal ureteroinguinal hernia was identified. The patient did well postoperatively, and the stent was removed 1 month later. CONCLUSIONS Only 20% of the ureteroinguinal hernias described in the literature are extraperitoneal. In our case presentation, we demonstrated successful identification and treatment of an extraperitoneal ureteroinguinal hernia. The diagnosis was made using a combination of the clinical presentation, CT of the abdomen and pelvis, and cystoscopy with retrograde pyelogram. The extraperitoneal classification was an intraoperative diagnosis. The treatment consisted of a temporizing ureter stent and definitive management with an open Lichtenstein repair. We recommend obtaining a CT scan when a patient presents with a combination of urinary symptoms and an inguinal hernia because this process was invaluable in our preoperative diagnosis. Stent placement at the time of diagnosis permitted an elective repair and aided in the identification of the ureter during the hernia repair.


Assuntos
Hérnia Inguinal , Ureter , Idoso , Hérnia Inguinal/diagnóstico por imagem , Hérnia Inguinal/cirurgia , Herniorrafia , Humanos , Masculino , Cintilografia , Tomografia Computadorizada por Raios X , Ureter/diagnóstico por imagem , Ureter/cirurgia
2.
Anal Chem ; 93(33): 11479-11487, 2021 08 24.
Artigo em Inglês | MEDLINE | ID: mdl-34380310

RESUMO

Multimodal optical imaging of tissue has significant potential to become an indispensable diagnostic tool in clinical pathology. Conventional bright-field microscopy provides contrast based on attenuation or reflectance of light, having no depth-related information and no molecular specificity. Recent developments in biomedical optics have introduced a variety of optical modalities, such as Raman spectroscopy (RS), fluorescence lifetime imaging microscopy (FLIM) of endogenous fluorophores, optical coherence tomography (OCT), and others, which provide a distinct characteristic, i.e., molecular, chemical, and morphological information, of the sample. To harvest the full analytical potential of those modalities, we have developed a novel multimodal imaging system, which allows the co-registered acquisition of OCT/FLIM/RS on a single device. The present implementation allows the investigation of biological tissues in the mesoscale range, 0.1-5 mm in a correlated manner. Due to the co-registered acquisition of the modalities, it is possible to directly compare and evaluate the corresponding information between the three modalities. Moreover, by additionally preparing and characterizing entire pathological hematoxylin and eosin (H&E) slides of head and neck biopsies, it is also possible to correlate the multimodal spectroscopic information to any location of the ground truth H&E information. To the best of our knowledge, this is the first development and implementation of a compact and clinically applicable multimodal scanning microscope, which combines OCT, FLIM, and RS together with the possibility for co-registering H&E information for a morpho-chemical tissue characterization and a correlation with the pathological ground truth (H&E) of the underlying signal origin directly in a clinical environment.


Assuntos
Análise Espectral Raman , Tomografia de Coerência Óptica , Testes Diagnósticos de Rotina , Microscopia de Fluorescência , Cintilografia
4.
Eur J Radiol ; 142: 109875, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34391057

RESUMO

Combination of radioligand imaging and therapy, so called radiotheranostics, is a novel tool of precision oncology with proven clinical value. In-depth knowledge of functional imaging nuances is critically needed for precise prognostication and guidance of management. Here, we review theranostic applications with up to Phase III type evidence for outcome improvement: Imaging and therapy of neuroendocrine neoplasms (NEN) exploiting high levels of somatostatin receptor (SSTR) expression and radiotheranostics of prostate cancer targeting the prostate specific membrane antigen (PSMA). This narrative review focusses on these two applications and elucidates patient selection and response assessment by radioligand scintigraphy and/or positron emission tomography. Furthermore, we provide a brief outlook on future applications for novel targets outside of NEN and prostate cancer.


Assuntos
Medicina de Precisão , Neoplasias da Próstata , Humanos , Masculino , Neoplasias da Próstata/diagnóstico por imagem , Radiologistas , Cintilografia , Tomografia Computadorizada por Raios X
5.
Nucl Med Rev Cent East Eur ; 24(2): 110-112, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34382678

RESUMO

A 31-year-old woman who had multiple orthopedic surgeries on the left lower limb and recently suffered from pain and redness in the lateral left lower thigh was referred to the hospital to rule out osteomyelitis by [99mTc]UBI scintigraphy. Except soft tissue inflammation in the mentioned region, the scan showed significant and diffuse both lungs uptake incidentally. The patient had experienced symptoms of COVID-19 disease recently. Chest HRCT scan also revealed multiple segmental ground-glass opacities (GGOs) which were typical features for lung involvement of COVID-19 associated pneumonia.


Assuntos
COVID-19/diagnóstico por imagem , Achados Incidentais , Compostos de Organotecnécio , Fragmentos de Peptídeos , Adulto , Feminino , Humanos , Cintilografia
6.
Nucl Med Rev Cent East Eur ; 24(2): 113-114, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34382679

RESUMO

This report presents a case of a 49-year-old woman with complaint of sore throat and front neck pain, who referred to a hospital for thyroid scan due to suppressed TSH level (0.005 mU/L). Diffuse and bilateral lungs uptake in the scan was noticed incidentally. The patient had positive history of COVID-19 symptoms. Multifocal and bilateral ground-glass opacities (GGOs) in both lungs were compatible with typical features of lung involvement in COVID-19-associated pneumonia.


Assuntos
COVID-19/diagnóstico por imagem , Achados Incidentais , Glândula Tireoide/diagnóstico por imagem , Feminino , Humanos , Pessoa de Meia-Idade , Cintilografia
7.
Anal Chem ; 93(36): 12296-12304, 2021 09 14.
Artigo em Inglês | MEDLINE | ID: mdl-34347443

RESUMO

Scanning ion conductance microscopy (SICM) is a type of in situ measurement technology for noncontact detection of samples in electrolytes with nanoscale resolution and has been used increasingly in biomedical and electrochemical fields in recent years. However, there is an inherent contradiction in the technique that makes SICM's sensitivity and accuracy difficult to balance. Higher sensitivity allows for faster probe speeds and higher scanning reliability but leads to lower accuracy, and vice versa. To resolve this problem, an adaptive sensitivity scanning method is proposed here that is designed to increase SICM's imaging efficiency without reducing its scanning reliability and accuracy. In the proposed scanning method, the sensitivity is automatically switched via the bias voltage based on the probe-sample distance. When the probe is located far away from the sample, the probe then predetects the sample position rapidly with high sensitivity. When the sample has been sensed in the high-sensitivity phase, the probe then detects the sample with low sensitivity. The basic theory and the feasibility of the alterable sensitivity detection strategy is also studied using the finite element method (FEM) and by performing experiments in this work. Finally, through testing of the standard silicon and polydimethylsiloxane (PDMS) samples, the proposed method is shown to increase SICM imaging efficiency significantly by up to 5 times relative to the conventional hopping mode without sacrificing the scanning accuracy and reliability.


Assuntos
Microscopia , Íons , Cintilografia , Reprodutibilidade dos Testes
8.
Anal Chem ; 93(36): 12281-12288, 2021 09 14.
Artigo em Inglês | MEDLINE | ID: mdl-34460243

RESUMO

Scanning ion conductance microscopy (SICM) is a powerful and versatile technique that allows an increasingly wide range of interfacial properties and processes to be studied. SICM employs a nanopipette tip that contains electrolyte solution and a quasi-reference counter electrode (QRCE), to which a potential is applied with respect to a QRCE in a bathing solution, in which the tip is placed. The work herein considers the potential-controlled delivery of uncharged electroactive molecules (solute) from an SICM tip to a working electrode substrate to determine the effect of the substrate on electroosmotic flow (EOF). Specifically, the local delivery of hydroquinone from the tip to a carbon fiber ultramicroelectrode (CF UME) provides a means of quantifying the rate of mass transport from the nanopipette and mapping electroactivity via the CF UME current response for hydroquinone oxidation to benzoquinone. EOF, and therefore species delivery, has a particularly strong dependence on the charge of the substrate surface at close nanopipette-substrate surface separations, with implications for retaining neutral solute within the tip predelivery and for the delivery process itself, both controlled via the applied tip potential. Finite element method (FEM) simulations of mass transport and reactivity are used to explain the experimental observations and identify the nature of EOF, including unusual flow patterns under certain conditions. The combination of experimental results with FEM simulations provides new insights on mass transport in SICM that will enhance quantitative applications and enable new possibilities for the use of nanopipettes for local delivery.


Assuntos
Eletro-Osmose , Microscopia , Eletrodos , Íons , Cintilografia
9.
Sensors (Basel) ; 21(16)2021 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-34450785

RESUMO

The article describes a method of simulated 3D scanning of triangle meshes based on ray casting which is used to find the optimal configuration of a real 3D scanner turntable. The configuration include the number of scanners, their elevation above the rotary table and the number of required rotation steps. The evaluation is based on the percentage of the part surface covered by the resulting point cloud, which determines the ability to capture all details of the shape. Principal component analysis is used as a secondary criterion to also evaluate the ability to capture the overall general proportions of the model.


Assuntos
Imageamento Tridimensional , Cintilografia
10.
Sensors (Basel) ; 21(16)2021 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-34450905

RESUMO

This paper describes the use of microwave technology to identify anti-counterfeiting markers on banknotes. The proposed method is based on a robust near-field scanning microwave microscope specially developed to measure permittivity maps of heterogeneous paper specimens at the micrometer scale. The equipment has a built-in vector network analyzer to measure the reflection response of a near-field coaxial probe, which makes it a standalone and portable device. A new approach employing the information of a displacement laser and the cavity perturbation technique was used to determine the relationship between the dielectric properties of the specimens and the resonance response of the probe, avoiding the use of distance-following techniques. The accuracy of the dielectric measurements was evaluated through a comparative study with other well-established cavity methods, revealing uncertainties lower than 5%, very similar to the accuracy reported by other more sophisticated setups. The device was employed to determine the dielectric map of a watermark on a 20 EUR banknote. In addition, the penetration capabilities of microwave energy allowed for the detection of the watermark when concealed behind dielectric or metallic layers. This work demonstrates the benefits of this microwave technique as a novel method for identifying anti-counterfeiting features, which opens new perspectives with which to develop optically opaque markers only traceable through this microwave technique.


Assuntos
Microscopia , Micro-Ondas , Cintilografia
11.
Int J Mol Sci ; 22(15)2021 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-34361080

RESUMO

Photoimmunotherapy (PIT) is an upcoming potential cancer treatment modality, the effect of which is improved in combination with chemotherapy. PIT causes a super-enhanced permeability and retention (SUPR) effect. Here, we quantitatively evaluated the SUPR effect using radiolabeled drugs of varying molecular weights (18F-5FU, 111In-DTPA, 99mTc-HSA-D, and 111In-IgG) to determine the appropriate drug size. PIT was conducted with an indocyanine green-labeled anti-HER2 antibody and an 808 nm laser irradiation. Mice were subcutaneously inoculated with HER2-positive cells in both hindlimbs. The tumor on one side was treated with PIT, and the contralateral side was not treated. The differences between tumor accumulations were evaluated using positron emission tomography or single-photon emission computed tomography. Imaging studies found increased tumor accumulation of agents after PIT. PIT-treated tumors showed significantly increased uptake of 18F-5FU (p < 0.001) and 99mTc-HSA-D (p < 0.001). A tendency toward increased accumulation of 111In-DTPA and 111In-IgG was observed. These findings suggest that some low- and medium-molecular-weight agents are promising candidates for combined PIT, as are macromolecules; hence, administration after PIT could enhance their efficacy. Our findings encourage further preclinical and clinical studies to develop a combination therapy of PIT with conventional anticancer drugs.


Assuntos
Anticorpos Monoclonais/administração & dosagem , Sistemas de Liberação de Medicamentos , Imunoterapia/métodos , Neoplasias/terapia , Fototerapia/métodos , Cintilografia/métodos , Animais , Apoptose , Proliferação de Células , Terapia Combinada , Humanos , Verde de Indocianina/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Nus , Neoplasias/diagnóstico por imagem , Neoplasias/metabolismo , Neoplasias/patologia , Células Tumorais Cultivadas , Ensaios Antitumorais Modelo de Xenoenxerto
12.
Mayo Clin Proc ; 96(8): 2185-2191, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34353472

RESUMO

Whether diagnostic timing in transthyretin (TTR) cardiac amyloidosis (CA) predisposes patients to worse outcomes is unresolved. We aimed to describe the long-term association of diagnostic timing (time from first onset of symptoms consistent with CA leading to medical contact to definitive diagnosis) with mortality in patients with wild-type TTR-CA (ATTRwt-CA). Overall, we reviewed the medical records of 160 patients seen at a tertiary care amyloidosis unit from January 1, 2016, to January 1, 2020 (median [interquartile range] follow-up, 21 [10 to 34] months), and compared them by survival. Median diagnostic timing was 4 (2 to 12) months and was longer in nonsurvivors (9 [3 to 15] vs 3 [1 to 7] months; P<.001). Patients diagnosed 6 or more months after symptom onset had higher mortality, with a median survival of 30 months (95% CI, 22 to 37 months). On Cox multivariable analysis, timing was independently associated with all-cause mortality (hazard ratio per month increase, 1.049 [95% CI, 1.017 to 1.083]) together with age at diagnosis, disease stage, New York Heart Association class, and coronary artery disease. In conclusion, diagnostic timing of ATTRwt-CA is associated with mortality. Timely diagnosis is warranted whenever "red flags" are present.


Assuntos
Neuropatias Amiloides Familiares/diagnóstico , Cardiomiopatias/metabolismo , Diagnóstico Precoce , Idoso , Idoso de 80 Anos ou mais , Cardiomiopatias/diagnóstico , Diagnóstico Diferencial , Eletrocardiografia , Feminino , Humanos , Masculino , Microscopia Imunoeletrônica , Cintilografia
13.
Harefuah ; 160(7): 412-414, 2021 Jul.
Artigo em Hebraico | MEDLINE | ID: mdl-34263565

RESUMO

INTRODUCTION: The current issue is dedicated to nuclear medicine in Israel. It contains articles concerning various fields in nuclear medicine including imaging and treatment. These articles provide a glimpse into the vast scope of nuclear medicine. Over the years, the nuclear medicine profession has undergone many changes and developed extensively. Currently, it is not just part of the imaging domain, but rather, it is an independent entity, that continues to grow and develop. This profession has had a great influence on patient health because of advanced imaging technologies, the possibility of treating with unique radioactive materials, and theranostics (imaging the therapeutic material) that enables the combination of diagnostic imaging and targeted treatment personally tailored for the patient. Today, nuclear medicine is considered one of the most dynamic and advanced professions. Research in nuclear medicine points to a future with ultrafast imaging technology. This includes a seemingly limitless number of new radiopharmaceuticals for diagnosis and treatment and collaborations with other scientific fields.


Assuntos
Medicina Nuclear , Humanos , Israel , Medicina de Precisão , Cintilografia , Compostos Radiofarmacêuticos
14.
Harefuah ; 160(7): 415-418, 2021 Jul.
Artigo em Hebraico | MEDLINE | ID: mdl-34263566

RESUMO

INTRODUCTION: In patients diagnosed with pulmonary hypertension (PH), V/Q lung scintigraphy performed in Nuclear Medicine departments can demonstrate pulmonary embolisms and diagnose chronic thromboembolic pulmonary hypertension (CTEPH). Lung scintigraphy has higher sensitivity and specificity for CTEPH in comparison to other imaging methods, and is considered to be the method of choice in the workup of patients with unexplained PH. In the case presented, lung scintigraphy performed at two time points in a patient with PH demonstrated chronic bilateral pulmonary embolisms and aided in the diagnosis of CTEPH.


Assuntos
Hipertensão Pulmonar , Medicina Nuclear , Embolia Pulmonar , Doença Crônica , Dispneia/diagnóstico , Dispneia/etiologia , Humanos , Hipertensão Pulmonar/diagnóstico por imagem , Hipertensão Pulmonar/etiologia , Embolia Pulmonar/complicações , Embolia Pulmonar/diagnóstico , Cintilografia , Síncope
15.
Harefuah ; 160(7): 429-432, 2021 Jul.
Artigo em Hebraico | MEDLINE | ID: mdl-34263569

RESUMO

INTRODUCTION: This case report presents a teenage girl hospitalized due to fever, left wrist pain and elevated inflammatory markers. These clinical findings, as well as a lytic lesion seen on plain radiographs and MRI in the distal left radius, led to the working diagnosis of acute osteomyelitis. Following 4 weeks of antibiotic therapy, a bone scan was conducted due to inadequate clinical response. It showed additional skeletal lesions and led to the final diagnosis of chronic recurrent multifocal osteomyelitis (CRMO). Treatment was changed to anti-inflammatory medications with a good response. This article presents key features of CRMO and emphasizes the role of skeletal scintigraphy in establishing the diagnosis.


Assuntos
Osteomielite , Adolescente , Criança , Doença Crônica , Feminino , Humanos , Imageamento por Ressonância Magnética , Osteomielite/diagnóstico por imagem , Cintilografia , Recidiva
16.
Vestn Otorinolaringol ; 86(3): 97-103, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34269032

RESUMO

A review of the literature is devoted to the description of modern diagnostic methods that are directed at detecting lacrimal pathway obstruction. The presented analysis is based on the study of data from Russian and foreign literary sources on both routine and high-tech lacrimal system examination methods, as well as on authors' experience in studying the diagnostic efficiency of imaging methods such as lacrimal scintigraphy, computed tomography with lacrimal pathway contrasting, and also single photon emission computed tomography. The article gives information about the advantages and disadvantages of the presented methods, highlights the questions of the prospects of their usage in practical dacryology.


Assuntos
Dacriocistorinostomia , Aparelho Lacrimal , Humanos , Aparelho Lacrimal/diagnóstico por imagem , Cintilografia , Federação Russa , Tomografia Computadorizada por Raios X
17.
Med Phys ; 48(9): 5047-5058, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34287952

RESUMO

PURPOSE: The ability of ultrasound to assess pathology is increasing with the development of quantitative parameters. Among these are a set of parameters derived from the recent H-scan analysis of subresolvable scattering. The emergence of these quantitative measures of tissue/ultrasound interactions now enables a study of the unique trajectories of multiparametric features in multidimensional space, representing the progression of specific diseases over time. We develop the mathematical and visual tools that are effective for classifying, quantifying, and visualizing the steady progression of several diseases from independent studies, all within a uniform framework. METHODS: After applying the H-scan analysis of ultrasound echoes, we trained a support vector machine (SVM) to classify the unique trajectories of progressive liver disease from fibrosis, steatosis, and pancreatic ductal adenocarcinoma (PDAC) metastasis. Our approaches include the development of trajectory maps and disease-specific color imaging stains. RESULTS: The multidimensional SVM image classification reached 100% accuracy across the three different studies. CONCLUSION: H-scan trajectories can be useful to track the progression of multiple classes of diseases, improving diagnosis, staging, and assessing the response to therapy.


Assuntos
Neoplasias Pancreáticas , Máquina de Vetores de Suporte , Humanos , Cintilografia , Ultrassonografia
19.
Rev Med Chil ; 149(1): 13-21, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34106131

RESUMO

BACKGROUND: Guidelines recommend estimating glomerular filtration rate (GFR) using creatinine-based equations (CBE). AIM: To evaluate the agreement between GFR measured using radionuclide imaging and estimated using creatinine-based equations. MATERIAL AND METHODS: In 421 patients aged 54 ± 17 years (47% women) GFR was estimated using the MDRD-4, CKD-EPI and the body surface adjusted Cockroft Gault equation. GFR was also measured using a radionuclide imaging method with 99mTc-DTPA. The concordance between estimated and measured GFR was calculated using Lin's concordance coefficient and Bland and Altman plots. RESULTS: Average GFR values obtained with CKD-EPI, MDRD-4, body surface adjusted Cockroft Gault equation and 99mTc-DTPA imaging were 75.9 ± 26.6, 76.3 ± 28.8, 77.1 ± 31.6 and 77.9 ± 28.4 ml/min/1.73 m2, respectively. There was no significant difference in means and 29% of participants had a GFR < 60 ml/min/1.73 m2 by CKD-EPI. The correlation was good between equations, but acceptable when compared with the 99mTc-DTPA imaging. The weighted kappa between CBEs was good, but low when comparing CBEs with measured GFR. The Lin's concordance coefficient between estimated and measured GFR was low. CONCLUSIONS: GFR measured by 99mTc-DTPA radionuclide imaging has a low correlation and poor concordance with estimations using CBE.


Assuntos
Insuficiência Renal Crônica , Creatinina , Feminino , Taxa de Filtração Glomerular , Humanos , Masculino , Cintilografia , Insuficiência Renal Crônica/diagnóstico por imagem
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