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1.
J Nerv Ment Dis ; 210(4): 257-263, 2022 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-35212665

RESUMO

ABSTRACT: We aimed to explore the prevalence and determinants of severe COVID-19 disease and mortality in patients with schizophrenia in this study. We conducted a retrospective observational study of 1620 patients with schizophrenia. Of the 1620 patients, 52 (3.2%) tested positive for SARS-CoV-19. Among SARS-CoV-2-positive patients, 40 patients were hospitalized, and 17 patients required intensive care unit admission due to COVID-19 (76.9% and 32.7%, respectively). Severe COVID-19 disease was noted in 17 patients (32.7%) requiring intubation. In the logistic regression analysis, antipsychotic dose, and comorbidity score were independently associated with a greater risk of severe COVID-19 disease in patients with schizophrenia. Our study suggests that factors such as age, sex, comorbidities, and a daily antipsychotic dose may have effects on the poor outcome of SARS-CoV-2 disease in schizophrenia patients. In addition, the current findings propose that mortality may be associated with an older age, comorbidity score, and a longer duration of psychiatric disease among the SARS-CoV-2-positive patients with schizophrenia. However, the findings of our study should be verified in prospective and larger sample studies.


Assuntos
COVID-19 , Esquizofrenia , COVID-19/epidemiologia , Comorbidade , Demografia , Hospitalização , Humanos , Estudos Prospectivos , Estudos Retrospectivos , Fatores de Risco , SARS-CoV-2 , Esquizofrenia/epidemiologia
2.
Schizophr Res ; 241: 187-196, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35139458

RESUMO

Psychotic episodes occur in a substantial proportion of patients suffering from major mood disorders (both unipolar and bipolar) at some point in their lives. The nature of these episodes is less well understood than the more common, non-psychotic periods of illness and hence their management is also less sophisticated. This is a concern because the risk of suicide is particularly high in this subtype of mood disorder and comorbidity is far more common. In some cases psychotic symptoms may be signs of a comorbid illness but the relationship of psychotic mood to other forms of psychosis and in particular its interactions with schizophrenia is poorly understood. Therefore, our targeted review draws upon extant research and our combined experience to provide clinical context and a framework for the management of these disorders in real-world practice - taking into consideration both biological and psychological interventions.


Assuntos
Transtorno Bipolar , Transtorno Depressivo Maior , Transtornos Psicóticos , Transtorno Bipolar/complicações , Transtorno Bipolar/diagnóstico , Transtorno Bipolar/terapia , Comorbidade , Transtorno Depressivo Maior/epidemiologia , Humanos , Transtornos do Humor/diagnóstico , Transtornos do Humor/etiologia , Transtornos do Humor/terapia , Transtornos Psicóticos/complicações , Transtornos Psicóticos/epidemiologia , Transtornos Psicóticos/terapia
3.
Multimedia | Recursos Multimídia | ID: multimedia-9712

RESUMO

O vídeo apresenta informações sobre o que é comorbidade e suas características. Também explica que pessoas com comorbidades possuem um risco maior de adoecer por SARS-CoV-2. O aplicativo FioLibras é um projeto do Instituto de Comunicação e Informação Científica e Tecnológica em Saúde da Fundação Oswaldo Cruz (Icict/Fiocruz), em parceria com o Núcleo de Estudos em Diversidade e Inclusão de Surdos da Universidade Federal Fluminense (Nuedis/UFF), e conta com financiamento do Fundo de Inovação da Fiocruz e do Ministério da Saúde, por meio do Programa Fiocruz de Fomento à Inovação (Inova Fiocruz).


Assuntos
Comorbidade , COVID-19 , Aplicativos Móveis , Disseminação de Informação , e-Acessibilidade , Línguas de Sinais
4.
Ars pharm ; 63(2)abr.-jun. 2022. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-202810

RESUMO

Introducción: La alfabetización en salud es una medida de la capacidad de los pacientes de leer, comprender y tomar decisiones en base a instrucciones médicas. La inadecuada alfabetización se asocia a un peor estado de salud en pacientes con enfermedades crónicas. El momento de la dispensación podría ser una oportunidad para evaluar esta condición por el farmacéutico de atención primariaEl objeto de este estudio fue evaluar la relación de alfabetización en salud y los valores de colesterol total y comorbilidades en personas con prescripción de hipolipemiantes atendidos en un centro de jubilados.Método:Se diseñó un estudio prospectivo donde se evaluó la relación de la alfabetización utilizando Short Assessment of Health Literacy for Spanish-speaking Adults y el valor de colesterol , medicamentos , factores de riesgo y comorbilidades. Todas estas variables se analizaron en forma integrada en un análisis multivariado. Resultados: Participaron 178 pacientes, 63% mujeres. El puntaje promedio de SAHLSA fue 43,4 ± 5,5. Se encontró una inadecuada alfabetización en 24%. pacientes El valor promedio de colesterol en estre grupo de pacientes fue 235,17mg/dl vs 193,53mg/dl quienes tenian adecuada alfabetización en salud.Se realizó un análisis multivariado que mostró asociación entre inadecuada alfabetización en salud, bajo nivel de educación y conocimiento del paciente . El número de internaciones y la aparición de eventos coronarios fueron significativamente mayor en los pacientes con alfabetización en salud insuficiente. Conclusiones: Se encontró relación directa entre el grado de alfabetización en salud y los valores de colesterol total en pacientes en tratamiento por hipercolesterolemia (AU)


Introduction: Health literacy is a measure of the ability of patients to read, understand and make decisions based on medical instructions. Inadequate health literacy is associated with poorer health in patients with chronic diseases. Time of dispensing could be an opportunity for the primary care pharmacist to evaluate this condition by the. The purpose of this study was to evaluate the relationship of Health literacy and the values of total cholesterol and comorbidities in people with a prescription of lipid-lowering drugs treated in a retirement center. Method: A prospective study was designed where the relationship of Health literacy was evaluated using Short Assessment of Health Literacy for Spanish-speaking Adults and the value of cholesterol, medications, risk factors and comorbidities. All these variables were analyzed in an integrated manner in a multivariate analysis.Results:178 patients participated, 63% women. The mean SAHLSA score was 43.4 ± 5.5. Inadequate HL was found in 24%. patients.The mean cholesterol value in patients with inadequate Health literacy was 235.17mg / dl vs 193.53mg / dl among those with adequate Health literacy.A multivariate analysis was performed that showed an association between inadequate Health literacy, the level of education and the patient’s knowledge of normal values of total cholesterol. The number of hospitalizations and the occurrence of coronary events were significantly higher in patients with insufficient Health literacy. Conclusions: A direct relationship was found between the degree of Health literacy and total cholesterol values in patients undergoing treatment for hypercholesterolemia (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Letramento em Saúde , Atenção Primária à Saúde , Hipolipemiantes/uso terapêutico , Colesterol/sangue , Hipercolesterolemia/tratamento farmacológico , Assistência Farmacêutica , Estudos Prospectivos , Fatores de Risco , Análise Multivariada , Comorbidade , Escolaridade , Estudos Transversais
7.
Lancet Public Health ; 7(6): e557-e568, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35660217

RESUMO

BACKGROUND: Comorbid mental illnesses and substance use disorders are associated with adverse criminal, social, and health outcomes. Yet, their burden is not reliably known among prison populations. We therefore aimed to estimate the prevalence of comorbid serious mental illnesses and substance use disorders (dual disorders) among people in prison worldwide. METHODS: In this systematic review and meta-analysis, we searched 15 electronic databases (ASSIA, CAB Abstracts, Criminal Justice Database, Embase, Global Health, Global Index Medicus, IBSS, MEDLINE, NCJRS, PAIS Index, PsycINFO, Russian Science Citation Index, Scielo, Social Services Abstracts, and Web of Science) and the grey literature (Open Grey and ProQuest Dissertations & Theses Global) for studies reporting the prevalence of serious mental illnesses and substance use disorders in prison populations published between Jan 1, 1980, and Sept 25, 2021, and contacted the authors of relevant studies. Empirical studies among unselected adult prison populations that applied representative sampling strategies and validated diagnostic instruments, and either reported the prevalence of dual disorders or had authors who could provide prevalence data in correspondence, were included. Two reviewers (GB and SDL) independently extracted data from the eligible studies; both current (up to 1 year) and lifetime prevalence were extracted, if available. We sought summary estimates. Our primary outcomes were comorbid non-affective psychosis with substance use disorders and comorbid major depression with substance use disorders. We conducted a random-effects meta-analysis, explored between-sample heterogeneity with meta-regression, and calculated odds ratios (ORs) to assess bidirectional relationships between mental and substance use disorders. Risk of bias was assessed by use of a standard tool. The study protocol was registered with PROSPERO, CRD42020207301. FINDINGS: Of 11 346 records screened, we identified 34 studies reporting the prevalence of dual disorders among individuals in prison and received unpublished prevalence data for 16 studies, totalling 50 eligible studies and 24 915 people. The mean quality score of included studies was 7·8 (SD 1·2). We found that 3·5% (95% CI 2·2-5·0) had current non-affective psychosis with any comorbid substance use disorder, representing 443 (49·2%) of 900 people with non-affective psychosis, and 9·1% (5·6-13·3) had current major depression and comorbid substance use disorders, representing 1105 (51·6%) of 2143 people with major depression. Between-sample heterogeneity was high (I2>80%). People in prison with current non-affective psychosis were significantly more likely to have substance use disorders compared with those without (OR 1·7, 95% CI 1·4-2·2). People with major depression had higher odds of substance use disorders than those without (1·6, 1·3-2·0). INTERPRETATION: Around half of the prison population with non-affective psychosis or major depression have a comorbid substance use disorder. Consideration should be given to screening for dual disorders and implementing integrated and scalable treatments. FUNDING: Economic and Social Research Council, Agencia Nacional de Investigación y Desarrollo (Chile), and the Wellcome Trust.


Assuntos
Transtornos Mentais , Transtornos Relacionados ao Uso de Substâncias , Adulto , Comorbidade , Humanos , Transtornos Mentais/epidemiologia , Prevalência , Prisões , Transtornos Relacionados ao Uso de Substâncias/epidemiologia
8.
Epilepsy Behav ; 132: 108738, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35665606

RESUMO

BACKGROUND: Depression is one of the most common comorbid psychiatric condition associated with epilepsy. It has a negative impact on the patient's quality of life. However, the underlying molecular mechanisms leading to depression are currently unclear. The aim of this study was to determine the hub genes associated with epilepsy and depression. METHODS: Gene expression profiles (GSE47752 and GSE20388) were downloaded from the gene expression omnibus (GEO) database. Differentially expressed genes (DEGs) for epilepsy and depression groups were separately searched. Subsequently, network analyses methods were employed to establish protein-protein interaction (PPI) networks, and to perform Gene Ontology (GO) terms and pathway enrichment analyses for co-expressed DEGs. RESULTS: A total of 772 genes were upregulated in patients with epilepsy whereas 91 genes were up-regulated in patients with depression. In addition, 1304 genes were down-regulated in epilepsy whereas 141 genes were down-regulated in patients with depression. Among co-expressed DEGs, 5 DEGs were up-regulated and 19 were down-regulated. Further analysis revealed that the co-expressed DEGs were involved in regulation of vasculature development, regulation of angiogenesis, glutamate receptor signaling pathway, cellular response to interleukin-1 and positive regulation of protein kinase B signaling. The Arc and Homer1 genes were identified as the common candidate genes involved in the pathogenesis of epilepsy and depression. CONCLUSIONS: Arc and Homer1 may contribute to the comorbidity of epilepsy and depression.


Assuntos
Proteínas do Citoesqueleto/metabolismo , Epilepsia , Redes Reguladoras de Genes , Proteínas do Tecido Nervoso/metabolismo , Comorbidade , Biologia Computacional/métodos , Análise de Dados , Depressão/complicações , Depressão/genética , Epilepsia/complicações , Epilepsia/epidemiologia , Epilepsia/genética , Perfilação da Expressão Gênica/métodos , Proteínas de Arcabouço Homer/genética , Humanos , Qualidade de Vida
9.
Open Heart ; 9(1)2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35649573

RESUMO

AIM: Inflammatory cytokines in patients with rheumatoid arthritis (RA) directly affect cardiac electrophysiology by inhibiting cardiac potassium currents, leading to delay of cardiac repolarisation and QT-prolongation. This may result in lethal arrhythmias. We studied whether RA increases the rate of out-of-hospital cardiac arrest (OHCA) in the general population. METHODS: We conducted a nested case-control in a cohort of individuals between 1 June 2001 and 31 December 2015. Cases were OHCA patients from presumed cardiac causes, and were matched with non-OHCA-controls based on age, sex and OHCA date. Cox-regression with time-dependent covariates was conducted to assess the association between RA and OHCA by calculating the HR and 95% CI. Stratified analyses were performed according to sex and presence of cardiovascular diseases. Also, the association between OHCA and use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with RA was studied. RESULTS: We included 35 195 OHCA cases of whom 512 (1.45%) had RA, and 351 950 non-OHCA controls of whom 3867 (1.10%) had RA. We found that RA was associated with increased rate of OHCA after adjustment for cardiovascular comorbidities and use of QT-prolonging drugs (HR: 1.22, 95% CI: 1.11 to 1.34). Stratification by sex revealed that increased OHCA rate occurred in women (HR: 1.32, 95% CI: 1.16 to 1.50) but not in men (HR: 1.12, 95% CI: 0.97 to 1.28; P value interaction=0.046). OHCA rate of RA was not further increased in patients with cardiovascular disease. Finally, in patients with RA, use of NSAIDs was not associated with OHCA. CONCLUSION: In the general population, RA is associated with increased rate of OHCA in women but not in men.


Assuntos
Artrite Reumatoide , Parada Cardíaca Extra-Hospitalar , Arritmias Cardíacas , Artrite Reumatoide/complicações , Artrite Reumatoide/diagnóstico , Artrite Reumatoide/tratamento farmacológico , Estudos de Casos e Controles , Comorbidade , Feminino , Humanos , Masculino , Parada Cardíaca Extra-Hospitalar/diagnóstico , Parada Cardíaca Extra-Hospitalar/epidemiologia
11.
Child Adolesc Psychiatr Clin N Am ; 31(3): 449-468, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35697395

RESUMO

Attention-deficit/hyperactivity disorder (ADHD) is the most frequent comorbid disorder that is observed at a higher rate and with greater morbidity in higher intellectually functioning populations with autism. Up to 85% of the populations with autism and 15% of individuals with ADHD suffer from a reciprocal comorbidity that is highly under-recognized in intellectually capable populations. Limited empirical evidence is available on the response of anti-ADHD agents in autism populations with ADHD. In autism spectrum disorder (ASD) populations, response to methylphenidate for the treatment of hyperactivity is worse than typically expected in the presence of the intellectual disability. The anti-ADHD response to atomoxetine in autism populations is worse than typically expected although tolerability is similar to that observed in the typicals. The hyperactivity response to guanfacine treatment in predominantly intellectually impaired populations with ASD is as robust as observed in the typicals although tolerability was worse than typically expected. Further trials are warranted to document the extent of atypical anti-ADHD response in intellectually capable populations with autism.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Transtorno do Espectro Autista , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Transtorno do Espectro Autista/epidemiologia , Comorbidade , Humanos , Deficiência Intelectual/epidemiologia
12.
13.
Methods Mol Biol ; 2496: 203-219, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35713866

RESUMO

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has spread on an unprecedented scale around the globe. Despite of 141,975 published papers on COVID-19 and several hundreds of new studies carried out every day, this pandemic remains as a global challenge. Biomedical literature mining helps the researchers to understand the etiology of the disease and to gain an in-depth knowledge of the disease, potential drugs, vaccines developed and novel therapies. In addition to the available treatments, there is a huge need to address the comorbidity-based disease mortality in case of COVID-19 patients with type 2 diabetes mellitus (T2D), hypertension and cardiovascular disease (CVD). In this chapter, we provide a hybrid protocol based on biomedical literature mining, network analysis of omics data, and deep learning for the identification of most potential drugs for COVID-19.


Assuntos
COVID-19 , Aprendizado Profundo , Diabetes Mellitus Tipo 2 , COVID-19/tratamento farmacológico , COVID-19/epidemiologia , Comorbidade , Mineração de Dados , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/epidemiologia , Humanos , RNA Viral , SARS-CoV-2
14.
Methods Mol Biol ; 2496: 237-258, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35713868

RESUMO

Drug-drug interactions (DDIs) and adverse drug reactions (ADRs) occur during the pharmacotherapy of multiple comorbidities and in susceptible individuals. DDIs and ADRs limit the therapeutic outcomes in pharmacotherapy. DDIs and ADRs have significant impact on patients' life and health care cost. Hence, knowledge of DDI and ADRs is required for providing better clinical outcomes to patients. Various approaches are developed by the scientific community to document and report the occurrences of DDIs and ADRs through scientific publications. Due to the enormously increasing number of publications and the requirement of updated information on DDIs and ADRs, manual retrieval of data is time consuming and laborious. Various automated techniques are developed to get information on DDIs and ADRs. One such technique is text mining of DDIs and ADRs from published biomedical literature in PubMed. Here, we present a recently developed text mining protocol for predicting DDIs and ADRs from PubMed abstracts.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Comorbidade , Mineração de Dados/métodos , Interações Medicamentosas , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico , Humanos , PubMed
15.
BMJ Open ; 12(6): e059254, 2022 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-35728897

RESUMO

INTRODUCTION: Previous studies indicate people with diabetes mellitus (DM) may have varying treatment outcomes when receiving treatment for tuberculosis (TB) and that TB infection or its treatment may predispose them to develop an abnormal blood glucose or type 2 DM. This has implications for Eswatini which is a high TB burden country and with increasing cases of non-communicable diseases including DM. This study will describe the epidemiology of DM-TB comorbidity in a prospective cohort of patients receiving TB treatment and identify best practices for integration of care for non-communicable diseases into TB services in Eswatini. METHODS AND ANALYSIS: This study will employ a mixed-methods approach. Data from a prospective cohort of newly enrolled patients with TB at 12 health facilities from 1 June 2022 to 30 September 2022, and followed up to 30 April 2023, will be used. For the qualitative, key informants who provide TB services at the health facilities will be interviewed. Quantitative data from patients will be analysed descriptively and by tests of association and multivariate modelling. Key informant interviews from healthcare workers will be analysed using content analysis. ETHICS AND DISSEMINATION: This research has been approved by the Eswatini Health and Human Research Review Board and participant confidentiality will be maintained. COVID-19 safety measures to reduce the risk of infection or transmission by researchers and participants have been instituted. Key programmatic findings and how they can impact healthcare delivery and access will be presented to the specific programme in the Eswatini Ministry of Health and other relevant stakeholders.


Assuntos
COVID-19 , Diabetes Mellitus , Doenças não Transmissíveis , Tuberculose , Comorbidade , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/terapia , Essuatíni/epidemiologia , Humanos , Doenças não Transmissíveis/epidemiologia , Estudos Prospectivos , Resultado do Tratamento , Tuberculose/complicações , Tuberculose/epidemiologia , Tuberculose/terapia
16.
Turk Psikiyatri Derg ; 33(2): 133-138, 2022.
Artigo em Inglês, Turco | MEDLINE | ID: mdl-35730513

RESUMO

Functional movement disorders (FMD) are abnormal involuntary movements that are not attributable to known neurological and neuroanatomical causes. In the past decade, FMD diagnoses have been based on positive factors that are inconsistent with neurological disorders and not on the exclusion of neurological disorders. In this report, we presented the case of a female patient who had been followed up for 4 years in multiple health centers with the diagnosis of a neurological disorder which was suspected in the previous 1 year to be of psychogenic origin. A neurological disorder comorbid with depression and FMD was diagnosed after admission as an inpatient to our clinic. By presenting this case, it was intended to emphasise the importance of follow up after diagnosing FMD, given its common basis with Parkinson's disease and the high incidence of comorbidites seen with it. Imaging and elecrophysiological techniques should be relied upon.for differentiating FMD and neurological diseases. Although psychological causes are significant disease risk and/or maintenance factors, they are not sufficient for explaining the aetiology of FMD, which requires a multidisciplinary approach. Keywords: Functional movement disorders, Parkinson's disease, DaTscan.


Assuntos
Transtorno Conversivo , Discinesias , Doença de Parkinson , Comorbidade , Transtorno Conversivo/psicologia , Feminino , Humanos , Pacientes Internados , Doença de Parkinson/complicações , Doença de Parkinson/diagnóstico
17.
Adv Skin Wound Care ; 35(7): 381-384, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-35723957

RESUMO

OBJECTIVE: Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disease with a higher prevalence in women. The disease results in a low quality of life as well as physical and psychological comorbidities. The authors sought to determine the effects of HS on women's self-perception and life experiences. METHODS: Semistructured interviews were conducted with 22 women of varying age and family status. The content was transcribed and subjected to both thematic and content analyses. RESULTS: Five themes and a number of subthemes were revealed, involving physical, emotional, coping, and functional aspects. Somatic features, especially pain, were the most troubling issues, along with the emotional burden of shame and loss of femininity and intimacy. However, women also revealed strength and expressed optimism. CONCLUSIONS: These findings reveal the inner world of women coping with HS, addressing multiple dilemmas, problems, and concerns. Healthcare providers should pay special attention to the specific needs of these patients. Additional research is needed to further shed light on the impact of HS on women.


Assuntos
Hidradenite Supurativa , Comorbidade , Feminino , Hidradenite Supurativa/diagnóstico , Hidradenite Supurativa/epidemiologia , Hidradenite Supurativa/terapia , Humanos , Dor , Prevalência , Qualidade de Vida
18.
Allergol Immunopathol (Madr) ; 50(S Pt 1): 30-36, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35726488

RESUMO

The association between symptoms of asthma, rhinoconjunctivitis (RC) and allergic conjunctivitis (AC) is frequent, and AC is considered a comorbidity of asthma and allergic rhinitis (AR). Ocular symptoms are often underestimated and undertreated.Differences according to gender were reported, because girls present symptoms more frequently. The development of RC depends on genetic and environmental factors, and recent studies have indicated that gender, family history of atopy, early sensitization, food allergy, and atopic dermatitis are risk factors for allergic RC. There are six well-defined clinical forms of ocular allergy: seasonal AC, perennial AC, vernal keratoconjunctivitis, atopic keratoconjunctivitis, and contact blepharoconjunctivitis.


Assuntos
Asma , Conjuntivite Alérgica , Dermatite Atópica , Hipersensibilidade Alimentar , Adolescente , Asma/epidemiologia , Criança , Comorbidade , Conjuntivite Alérgica/diagnóstico , Conjuntivite Alérgica/epidemiologia , Dermatite Atópica/epidemiologia , Feminino , Hipersensibilidade Alimentar/epidemiologia , Humanos
19.
Transl Psychiatry ; 12(1): 259, 2022 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-35732632

RESUMO

Depression and psychosis are often comorbid; they also have overlapping genetic and environmental risk factors, including trauma and area-level exposures. The present study aimed to advance understanding of this comorbidity via a network approach, by (1) identifying bridge nodes that connect clusters of lifetime depression and psychosis symptoms and (2) evaluating the influence of polygenic and environmental risk factors in these symptoms. This study included data from European ancestry participants in UK Biobank, a large population-based sample (N = 77,650). In Step 1, a network model identified bridge nodes between lifetime symptoms of depression and psychosis and functional impairment. In Step 2, genetic and environmental risk factors were incorporated to examine the degree to which symptoms associated with polygenic risk scores for depression and schizophrenia, lifetime exposure to trauma and area-level factors (including deprivation, air pollution and greenspace). Feelings of worthlessness, beliefs in unreal conspiracy against oneself, depression impairment and psychosis impairment emerged as bridges between depression and psychosis symptoms. Polygenic risk scores for depression and schizophrenia were predominantly linked with depression and psychosis impairment, respectively, rather than with specific symptoms. Cumulative trauma emerged as a bridge node associating deprivation with feelings of worthlessness and beliefs in unreal conspiracy, indicating that the experience of trauma is prominently linked with the co-occurrence of depression and psychosis symptoms related to negative views of oneself and others. These key symptoms and risk factors provide insights into the lifetime co-occurrence of depression and psychosis.


Assuntos
Transtornos Psicóticos , Esquizofrenia , Comorbidade , Depressão/epidemiologia , Depressão/genética , Humanos , Herança Multifatorial , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/epidemiologia , Transtornos Psicóticos/genética , Esquizofrenia/diagnóstico , Esquizofrenia/epidemiologia , Esquizofrenia/genética
20.
BMC Psychiatry ; 22(1): 419, 2022 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-35733107

RESUMO

BACKGROUND: Pain and depression often occur simultaneously, but the mechanism of this condition is still unclear. METHODS: The aim of this study was to examine the alterations of monoamine neurotransmitters, hypothalamic-pituitary-adrenal (HPA) axis hormones, and inflammation cytokines in hyperalgesia and depression comorbidities. The reserpine-induced "Sprague Dawley" (SD) rat models were used, and the concentrations of monoamine neurotransmitters serotonin (5-HT), norepinephrine (NE), dopamine (DA), and their metabolic products 5-hydroxyindoleacetic acid (5-HIAA), Homovanillic acid (HVA), 3,4-Dihydroxyphenylacetic acid (DOPAC) in raphe nucleus region were tested by High Performance Liquid Chromatography (HPLC). Serum levels of Adrenocorticotropic Hormone (ACTH), Cortisol (CORT), and inflammatory cytokines interleukin (IL)-1ß, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-4, IL-10 were assessed by enzyme linked immunosorbent assay. RESULTS: Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test. The concentrations of 5-HT and NE in raphe nucleus, and ACTH and CORT in serum were elevated in the model group. And the model group showed increases in serum IL-1ß and IL-6, and decrease in serum IL-10. CONCLUSION: More research in these areas is needed to understand the pathogenesis of the disease, so as to find more and better therapeutic targets.


Assuntos
Interleucina-10 , Reserpina , Hormônio Adrenocorticotrópico , Animais , Comorbidade , Citocinas , Depressão/induzido quimicamente , Depressão/complicações , Depressão/tratamento farmacológico , Humanos , Hidrocortisona , Hiperalgesia/induzido quimicamente , Inflamação , Interleucina-6 , Neurotransmissores , Norepinefrina , Ratos , Ratos Sprague-Dawley , Reserpina/efeitos adversos , Serotonina/metabolismo
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