Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.077
Filtrar
1.
Afr J Reprod Health ; 23(3): 42-48, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31782630

RESUMO

Sickle cell disease (SCD) is a chronic genetic hematological disorder with multiorgan involvement and is associated with complications during the pregnancy. This is a well-known disorder in Saudi Arabia, but no study has reported its outcomes in pregnant Saudi females of the Eastern region. This study was carried out to compare the fetomaternal outcome in patients with SCD with those without SCD. This was a retrospective cohort study done in the Eastern Province of Saudi Arabia in a tertiary care, teaching hospital, by retrieving the data through the code ICD-9 for SCD, the control group was also selected with comparable characteristics. A total of 302 SCD pregnant patients were included for comparison with 600 pregnant women without SCD as control, during the period of Jan 1, 2008 to December 31, 2018. After the data retrieval, percentages of complications were calculated between the study and control groups. Fischer's exact test and t-test were used for statistical analysis by using SPSS version 22. The results showed higher complication rates in pregnancies of patients with SCD. Hypertensive disorders (13.3%), abruptio placenta (1.6%), intrauterine growth restriction (19.2%), thromboembolism (6.6%) and stroke (2.6%) were all higher in SCD as compared to the control group .The complications of SCD itself including anemia (89.4%), acute chest syndrome (13.2%) and sickle cell crisis (39.2%) were also increased during the pregnancy. Both still birth (3.3%) and neonatal intensive care unit admission (1.6%) were also higher in SCD. SCD during the pregnancy is a high-risk situation and can lead to many fetomaternal complications; however, preconceptional counselling, early booking, a careful monitoring during pregnancy and multidisciplinary management approach can prevent potential adverse outcome in this regard.


Assuntos
Anemia Falciforme/complicações , Anemia Falciforme/fisiopatologia , Complicações Hematológicas na Gravidez/epidemiologia , Resultado da Gravidez/epidemiologia , Adolescente , Adulto , Anemia Falciforme/epidemiologia , Estudos de Casos e Controles , Feminino , Hospitais Universitários , Humanos , Hipertensão Induzida pela Gravidez , Gravidez , Complicações Hematológicas na Gravidez/etnologia , Estudos Retrospectivos , Arábia Saudita/epidemiologia , Natimorto/epidemiologia , Natimorto/etnologia , Tromboembolia/epidemiologia , Resultado do Tratamento , Adulto Jovem
2.
Pan Afr Med J ; 33: 325, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692871

RESUMO

Introduction: Anaemia in pregnancy remains a critical public health concern in many African settings; but its determinants are not clear. The purpose of this study was to assess anaemia at antenatal care initiation and associated factors among pregnant women in a local district of Ghana. Methods: A facility-based cross-sectional survey was conducted. A total of 378 pregnant women attending antenatal care at two health facilities were surveyed. Data on haemoglobin level, helminths and malaria infection status at first antenatal care registration were extracted from antenatal records booklets of each pregnant women. Questionnaires were then used to collect data on socio-demographic and dietary variables. Binary and multivariate logistic regression analyses were done to assess factors associated with anaemia. Results: The prevalence of anaemia was 56%, with mild anaemia being the highest form (31.0%). Anaemia prevalence was highest (73.2%) among respondents aged 15-19 years. Factors that significantly independently reduced the odds of anaemia in pregnancy after controlling for potential confounders were early (within first trimester) antenatal care initiation (AOR=5.01; 95% CI =1.41-17.76; p=0.013) and consumption of egg three or more times in a week (AOR=0.30; 95% CI=0.15-0.81; P=0.014). Conclusion: Health facility and community-based preconception and conception care interventions must not only aim to educate women and community members about the importance of early ANC initiation, balanced diet, protein and iron-rich foods sources that may reduce anaemia, but must also engage community leaders and men to address food taboos and cultural prohibitions that negatively affect pregnant woman.


Assuntos
Anemia/epidemiologia , Educação em Saúde/métodos , Complicações Hematológicas na Gravidez/epidemiologia , Cuidado Pré-Natal/estatística & dados numéricos , Adolescente , Adulto , Estudos Transversais , Feminino , Gana , Humanos , Gravidez , Prevalência , Inquéritos e Questionários , Adulto Jovem
3.
BMC Public Health ; 19(1): 1379, 2019 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-31655557

RESUMO

BACKGROUND: The prevalence of iron deficiency anaemia remains high in pregnant women and the situation may be worse for pregnant adolescents. This study aimed to comparatively analyse the trends and determinants of anaemia between adult and teenage pregnant women in rural Ghana. METHODS: A retrospective study design was employed. Data including primarily pregnancy history, haemoglobin levels and anaemia status were collected from the manual medical records of 1002 women stored in the repositories of two rural district hospitals in the Ashanti Region of Ghana over the years 2011-2015. Data was analysed using chi-square analysis, t-test, two-way ANOVA and binary logistic regression. Bivariate and multivariate analyses were also done to establish associations and predictors of anaemia. RESULTS: An overall drop in mean haemoglobin from 11.1 g/dl in 2011 to 10.6 g/dl in 2015 was observed for adults, while an overall increase from 9.4 g/dl to 10.2 g/dl occurred in teenagers. Further, anaemia prevalence declined at the 36th week of pregnancy, and from 2011 to 2015, for both teenagers and adults. Among factors tested for association with haemoglobin levels using bivariate and multivariate analyses, gestational age alone was significant (P = 0.028). Between-subject effects determined using 2-way ANOVA indicated year of pregnancy alone, as well as in combination with age group (F = 3.1, P = 0.019) significantly affected haemoglobin levels. From binary regression analysis, BMI (OR 0.967, 95% CI:0.936-0.999, P = 0.042), gestational age (OR 1.058, 95% CI:1.013-1.106, P = 0.011) and pregnancy year (OR-2012(0.402); 2013(0.53); 2014(0.569); 2015(0.817), 95% CI: 2012(0.256-0.631); 2013(0.338-0.829); 2014(0.366-0.886); 2015(0.501-1.333), P = 0.001) were found to be significant predictors of anaemia at first antenatal visit. Also, the trimester of reporting for antenatal care, specifically the second trimester (OR-0.261, 95% CI: 0.072-0.951, P = 0.042) and the pregnancy year (OR-2012(0.235); 2013(0.206); 2014(0.530); 2015(0.222), 95% CI: 2012(0.101-0.545); 2013(0.081-0.522); 2014(0.197-1.428); 2015(0.049-1.018), P = 0.003) were more significant at the 36th pregnancy week. CONCLUSIONS: Although the trends observed were decreasing in both adults and teenagers in the years reported, anaemia levels remained high for each year in either group. Anaemia, therefore remains a major health problem, especially in the areas studied, and antenatal interventions need a second look to know what might make them more effective.


Assuntos
Anemia/epidemiologia , Complicações Hematológicas na Gravidez/epidemiologia , População Rural/estatística & dados numéricos , Adolescente , Adulto , Feminino , Gana/epidemiologia , Humanos , Gravidez , Estudos Retrospectivos , Fatores de Risco
4.
Afr J Reprod Health ; 23(2): 35-43, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31433592

RESUMO

Anemia in pregnancy is a key public health problem worldwide. It results from a wide variety of causes. The World Health Organization (WHO) has recommended specific measures to help prevent anemia during pregnancy, which countries are required to integrate into their antenatal care. This study was designed to determine the factors influencing the use of anaemia preventing measures among antenatal clinic attendees in the Kintampo North Municipality, Ghana. A cross sectional study was conducted among pregnant women attending the clinics after 36 weeks of pregnancy. Demographic data and information on use of all interventions were obtained using a structured questionnaire. The factors associated with the use of the interventions were identified using multiple logistic regression. The use of all anemia preventing interventions among pregnant women was found to be 30%. The study identified that use of all anemia preventing measures among pregnant women is quite low. Provision of antihelmithics to pregnant women and their health education on the benefits of the use of anaemia preventing measures would help increase the usage of the interventions.


Assuntos
Anemia/prevenção & controle , Complicações Hematológicas na Gravidez/prevenção & controle , Cuidado Pré-Natal/estatística & dados numéricos , Adolescente , Adulto , Instituições de Assistência Ambulatorial , Anemia/epidemiologia , Estudos Transversais , Feminino , Gana/epidemiologia , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Gravidez , Complicações Hematológicas na Gravidez/epidemiologia , Complicações Parasitárias na Gravidez/prevenção & controle , Gestantes , Fatores de Risco , Inquéritos e Questionários , Adulto Jovem
6.
BMC Pregnancy Childbirth ; 19(1): 236, 2019 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-31286878

RESUMO

BACKGROUND: Malaria in pregnancy increases the risk of adverse birth outcomes such as low birth weight (LBW), maternal and foetal anemia. In Tanzania, some areas have attained low malaria transmission. However, data on the burden of preterm delivery, LBW, maternal and foetal anemia following substantial reduction of malaria transmission in recent years is still scarce in these settings. METHODS: A study involving 631 pregnant women was conducted at Mwananyamala referral hospital in Dar es Salaam from April to August, 2018. Study enrollment was done prior to delivery. Structured interview and antenatal clinic cards were used to obtain data including the use of intermittent preventive therapy in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP). Infants birth weights were recorded, maternal venous and cord blood were taken for testing of malaria and determination of haemoglobin (Hb) levels. Chi-square test and regression analysis were done to identify risk factors for preterm delivery, LBW, maternal and foetal anemia. RESULTS: The prevalence of malaria among mothers who used at least one dose of IPTp-SP was 0.6% (4/631). Fourteen mothers (2.2%) did not use IPTp-SP and had no malaria infection. The prevalence of maternal anemia, LBW, foetal anemia and preterm delivery was 40.6, 6.5, 5.9 and 9.2% respectively. Participants who were malaria positive had 11 times more risk of LBW compared to those who were negative (AOR, 11; 95%, CI 1.07-132.2; p = 0.04). The risk of delivering babies with LBW was 1.12 times high among mothers who were ≤ 36 weeks of gestation (AOR, 1.12; 95% CI, 0.06-0.25; p = < 0.001). The use of ≥3 doses of IPTp-SP was associated with 83% decrease in risk of LBW compared to those who did not use any dose of IPTp-SP (AOR, 0.17; 95% CI, 0.03-0.88; p = 0.05). Severe anaemia at delivery was associated with seven times increased risk of preterm delivery compared to non-anemic participants (AOR, 6.5; 95% CI, 1.49-28.16; p = 0.013). CONCLUSION: Despite the reduced malaria transmission and use of IPTp-SP, prevalence of preterm delivery, maternal anemia, LBW and foetal anemia is still high in Tanzania. The recommended ≥3 doses of IPTp-SP should continue be provided even in areas with substantial reduction of malaria.


Assuntos
Antimaláricos/uso terapêutico , Malária/prevenção & controle , Complicações Parasitárias na Gravidez/prevenção & controle , Pirimetamina/uso terapêutico , Sulfadoxina/uso terapêutico , Adolescente , Adulto , Anemia/epidemiologia , Anemia/parasitologia , Anemia/prevenção & controle , Estudos Transversais , Combinação de Medicamentos , Feminino , Humanos , Recém-Nascido de Baixo Peso , Malária/epidemiologia , Pessoa de Meia-Idade , Gravidez , Complicações Hematológicas na Gravidez/epidemiologia , Complicações Hematológicas na Gravidez/parasitologia , Complicações Hematológicas na Gravidez/prevenção & controle , Complicações Parasitárias na Gravidez/epidemiologia , Nascimento Prematuro/epidemiologia , Nascimento Prematuro/parasitologia , Nascimento Prematuro/prevenção & controle , Prevalência , Fatores de Risco , Tanzânia , Adulto Jovem
7.
BMC Pregnancy Childbirth ; 19(1): 269, 2019 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-31357932

RESUMO

BACKGROUND: The occurrence of thrombocytopenia is as high as 7-12% in pregnancy, yet minimum platelet count safe for cesarean section remains unknown. METHODS: In this retrospective noninferior cohort study, we consecutively included patients undergoing cesarean section for a period of 6 years in a tertiary hospital and excluded patients at very high risk for excessive hemorrhage. The included patients with preoperative platelet count of 50-100 × 109/L were defined as the thrombocytopenic group. The control group were eligible patients with preoperative platelet count>150 × 109/L, matched to the thrombocytopenic group by age and operation timing in a 1:2 ratio. Mixed effect model was used to analyze the effect of thrombocytopenia based on a noninferiority assumption. The predefined noninferiority delta of bleeding was 50 mL. RESULTS: There was no significant difference of the calculated blood loss between the thrombocytopenic and the control group (mean difference = 8.94, 95% CI - 28.34 mL to 46.09 mL). No statistical difference was observed in the requirement for blood transfusion, visually estimated blood loss, or the incidence of adverse events between groups. Although there were more patients admitted to intensive care unit (odds ratio = 12, 95% CI 2.69-53.62, p = 0.001) in the thrombocytopenic group, most of them required critical care for reasons other than hemorrhage. The thrombocytopenic group had longer length of hospital stay (mean difference = 0.40 days, 95% CI 0.09-0.71, p = 0.011), but the difference was considered as clinically insignificant. CONCLUSIONS: Preoperative moderate thrombocytopenia is not associated with increased blood loss, blood transfusion, or occurrence of adverse events in patients undergoing cesarean section in absence of additional bleeding risk.


Assuntos
Perda Sanguínea Cirúrgica/estatística & dados numéricos , Cesárea/estatística & dados numéricos , Complicações Hematológicas na Gravidez/epidemiologia , Resultado da Gravidez/epidemiologia , Trombocitopenia/epidemiologia , Adulto , Perda Sanguínea Cirúrgica/prevenção & controle , Estudos de Coortes , Feminino , Humanos , Transfusão de Plaquetas , Gravidez , Estudos Retrospectivos , Trombocitopenia/complicações , Adulto Jovem
8.
BMC Res Notes ; 12(1): 310, 2019 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-31151463

RESUMO

OBJECTIVES: Anemia remains a major public health problem in Ethiopia, which causes maternal and fetal severe consequences. In Tigrai, there are limited literatures on prevalence of anemia and associated factors among pregnant women. Thus, a hospital based cross-sectional study was conducted to determine the prevalence and associated factors of anemia in Adigrat General Hospital. Data was analyzed and computed using SPSS version 22. p value = 0.05 at 95% confidence interval was considered statistically significant. RESULTS: Overall prevalence of Anemia among the pregnant women attending Adigrat General Hospital was 7.9%. About 62.5% and 37.5% of the anemic women were with mild (Hgb: 10.0-10.9 g/d1) and moderate (Hgb: 7-9.9 g/dl) type respectively. Factors like, residing in rural areas increases risk of anemia by 6 times (AOR = 6, 95% CI 1.34, 27.6, p = 0.019), participants having current blood loss (AOR = 3.4, 95% CI 1.16, 10.2, p = 0.026), having history of recent abortion (AOR = 7.9, 95% CI 2.23, 28.1, p = 0.001) and gestational age in the third trimester (AOR = 4.9, 95% CI 1.39, 17.6, p = 0.013) were statistically associated with anemia. Generally, prevalence of anemia is found to be low in the study area. However, it should be given due attention. Therefore, strong endeavor is needed to control anemia among pregnant women by assessing different micronutrient deficiencies for further prevention.


Assuntos
Anemia/epidemiologia , Complicações Hematológicas na Gravidez/epidemiologia , Cuidado Pré-Natal/métodos , População Rural/estatística & dados numéricos , Adolescente , Adulto , Anemia/diagnóstico , Anemia/prevenção & controle , Estudos Transversais , Etiópia/epidemiologia , Feminino , Hospitais Gerais , Humanos , Gravidez , Complicações Hematológicas na Gravidez/diagnóstico , Complicações Hematológicas na Gravidez/prevenção & controle , Prevalência , Fatores de Risco , Adulto Jovem
9.
BMC Infect Dis ; 19(1): 483, 2019 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-31146689

RESUMO

BACKGROUND: Previous studies reported contradicting findings about the association between intestinal parasitosis and maternal anemia. In this study we aimed to determine the prevalence of intestinal parasitic infection and its association with anemia among pregnant women in Wondo Genet district, Southern Ethiopia. METHODS: This facility-based cross-sectional study was conducted in June and July 2018. Pregnant women (n = 352) were randomly drawn from five health centers using antenatal care follow-up lists. Trained data collectors administered the questionnaire. Capillary blood was collected and analyzed for hemoglobin using the HemoCue method. Stool sample was collected following standard procedure and analyzed for the presence and types of intestinal parasites using direct microscopy with Formalin-ether concentration technique. Association between intestinal parasitosis and anemia was measured using multivariable binary logistic regression analysis. The outputs are presented using adjusted odds ratio (AOR) with 95% confidence intervals (CI). RESULTS: The overall prevalence of intestinal parasitic infection was 38.7% (95% CI: 33.6-43.8%). One-tenth (9.7%) of the pregnant women were infected with polyparasites. Ascaris lumbricoides was the predominant infection encountered in 24.9% of the women. The other infections identified were: hookworms (11.2%), Giardia lamblia (5.4%), Entamoeba histolytica (3.4%), Trichuris trichiura (2.9%) and Schistosoma mansoni (2.3%). The mean (± standard deviation) hemoglobin concentration was 12.3 (±1.9) g/dl and 31.5% (95% CI: 26.6-36.4%) women were anemic (hemoglobin < 11 g/dl). The prevalence of anemia among women infected with intestinal parasite (55.6%) was substantially higher than the prevalence in their counterparts (16.4%) (p <  0.001). In a multivariable model adjusted for multiple potential confounders including socio-economic status indicators, the odds of anemia were six times increased (AOR = 6.14, 95% CI: 2.04-18.45) among those affected by at least one intestinal parasite. CONCLUSION: Strengthening the existing water, sanitation and hygiene programs and routine deworming of pregnant mothers may help to reduce the burden of both intestinal parasitic infection and anemia in pregnant women.


Assuntos
Anemia/epidemiologia , Enteropatias Parasitárias/epidemiologia , Complicações Hematológicas na Gravidez/epidemiologia , Complicações Parasitárias na Gravidez/epidemiologia , Adolescente , Adulto , Anemia/complicações , Anemia/parasitologia , Animais , Estudos Transversais , Etiópia/epidemiologia , Feminino , Humanos , Higiene , Enteropatias Parasitárias/complicações , Masculino , Gravidez , Complicações Hematológicas na Gravidez/parasitologia , Prevalência , Saneamento , Classe Social , Adulto Jovem
10.
Ann Hematol ; 98(7): 1573-1582, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31073646

RESUMO

Iron-deficiency anemia (IDA) was the main condition contributing to higher rates of years lived with disabilities in women in 2016. To date, few studies have investigated gender differences in determinants of IDA in Europe. The aim of the present study was to evaluate the determinants of IDA among females and males in four European countries. IDA determinants were estimated using multivariable Cox regression based on information gathered from national primary care databases, namely Italy (for years 2002-2013), Belgium, Germany, and Spain (for years 2007-2012). Adjusted hazard ratios (aHR) with 95% confidence intervals (CIs) were estimated. Age was significantly associated with IDA in females of childbearing age in all four countries, as well as pregnancy, for which the aHR ranged from 1.20 (95% CI 1.15-1.25) in Italy to 1.88 (95% CI 1.53-2.31) in Germany. In males, the aHR increased with age starting from the 65-69 age group. Menometrorrhagia was associated with IDA in Germany (aHR 2.71, 95% CI 1.96-3.73), Italy (aHR 1.80, 95% CI 1.60-2.03), and Spain (aHR 1.52, 95% CI 1.31-1.76). A greater risk for women with alopecia was also observed. Weakness and headache indicated a higher risk in both men and women. Patients with diseases characterized by blood loss or gastrointestinal malabsorption were also at significantly increased risk. Physicians should encourage women of childbearing age to adhere to dietary recommendations regarding iron intake and regularly prescribe screening of iron status. Upper and lower gastrointestinal investigations should be recommended for patients with a confirmed diagnosis of IDA.


Assuntos
Anemia Ferropriva/epidemiologia , Bases de Dados Factuais , Caracteres Sexuais , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Anemia Ferropriva/dietoterapia , Anemia Ferropriva/fisiopatologia , Criança , Pré-Escolar , Europa (Continente) , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Gravidez , Complicações Hematológicas na Gravidez/tratamento farmacológico , Complicações Hematológicas na Gravidez/epidemiologia , Complicações Hematológicas na Gravidez/fisiopatologia
11.
Eur J Haematol ; 103(2): 73-79, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31107984

RESUMO

Given the wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms associated with the disorder, pregnancy and delivery in von Willebrand disease (VWD) represent a significant clinical challenge. The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition. However, there are also instances during pregnancy (amniocentesis, vaginal bleeding associated with placental detachment, sudden abortion) that may require urgent hemostatic treatment to prevent bleeding. Thus, women with VWD should start pregnancy after being well characterised as to their type, subtype and treatments. Women with VWD who have VWF and FVIII basal levels >30 U/dL typically normalise these levels at the end of pregnancy and specific anti-haemorrhagic prophylaxis is seldom required. On the contrary, those with basal levels <20 U/dL usually show a lesser increase and specific treatment is required. Some women with DNA variants associated with increased clearance can be treated with desmopressin, while those unresponsive or with contra-indications to this agent need replacement therapy. For these latter women, the risk of vaginal bleeding during pregnancy may be increased and prophylaxis with VWF concentrates required. Similarly, women with type 2 VWD who maintain reduced VWF activity throughout pregnancy require replacement therapy with FVIII/VWF concentrates. Delayed postpartum bleeding may occur when replacement therapy is not continued for some days. Tranexamic acid is useful at discharge to avoid excessive lochia.


Assuntos
Parto Obstétrico , Parto , Complicações Hematológicas na Gravidez/diagnóstico , Complicações Hematológicas na Gravidez/terapia , Doenças de von Willebrand/diagnóstico , Doenças de von Willebrand/terapia , Amniocentese , Biópsia , Parto Obstétrico/métodos , Parto Obstétrico/estatística & dados numéricos , Gerenciamento Clínico , Fator VIII , Feminino , Hemorragia/epidemiologia , Hemorragia/etiologia , Humanos , Parto/sangue , Período Pós-Parto , Guias de Prática Clínica como Assunto , Gravidez , Complicações Hematológicas na Gravidez/sangue , Complicações Hematológicas na Gravidez/epidemiologia , Risco , Doenças de von Willebrand/sangue , Doenças de von Willebrand/epidemiologia , Fator de von Willebrand
12.
Clin Lab ; 65(4)2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30969067

RESUMO

BACKGROUND: Anemia, particularly pregnancy related iron deficiency anemia, increases the risk of maternal morbidity and mortality and the effects are more devastating in less developed and developing continents where pregnant women have low socioeconomic status. Thus, this study aimed to assess the prevalence and associated factors of anemia and iron deficiency anemia among pregnant women. METHODS: This institution based, cross-sectional study was conducted from January 1 to April 30, 2015 on a total of 217 pregnant women attending at University of Gondar Hospital, Northwest Ethiopia. A structured, pretested questionnaire was used to obtain sociodemographic information, nutritional factors, obstetrics and gynecological factors, and clinical condition. About 3 mL blood sample was collected for hemoglobin and serum ferritin deter-mination. Hgb concentrations and other RBC parameters were analyzed using a Cell Dyne 1800 hematology analyzer. Serum ferritin was measured by an automated Elecsys 1,020 using commercial kits. The data was entered to Epi info version 3.5.3 software and analyzed using SPSS 20. Frequency, proportion, and summery statistics was used to describe the study population in relation to study variables. Bi-variable and multi-variable statistical analysis was used. P-value < 0.05 was considered as statically significant. RESULTS: Out of 217 women enrolled in the study, 28 (12.9%) were found to be anemic with 75% mild, 21.4% moderate and 3.6% severe type of anemia. Anemia was more prevalent in the first (21%) and third (17.9%) trimesters. The overall prevalence of iron deficiency anemia was 3.2% (7/217) while from anemic pregnant women one fourth (25%) of them developed iron deficiency anemia. CONCLUSIONS: The overall prevalence of anemia was low and it was considered a mild public health problem. In this study, there were no statistically associated risk factors for anemia. Based on this finding, iron supplementation should be encouraged as a prophylactic measure.


Assuntos
Anemia Ferropriva/epidemiologia , Anemia/epidemiologia , Complicações Hematológicas na Gravidez/epidemiologia , Cuidado Pré-Natal/organização & administração , Adolescente , Adulto , Estudos Transversais , Etiópia/epidemiologia , Feminino , Ferritinas/sangue , Hemoglobinas/análise , Humanos , Análise Multivariada , Pobreza , Gravidez , Prevalência , Controle de Qualidade , Risco , Fatores de Risco , Inquéritos e Questionários , Adulto Jovem
13.
BMC Public Health ; 19(1): 397, 2019 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-30975203

RESUMO

BACKGROUND: Iron deficiency is the most prevalent nutrient deficiency and the most common cause of anaemia worldwide. Because of the increased iron requirements during pregnancy, iron deficiency can lead to maternal anaemia and reduced newborn iron stores. We examined the proportion and risk factors of iron deficiency among pregnant women in a developed Asian country. METHODS: Within a prospective cohort in Singapore, 985 Asian women were assessed for iron status at 26-28 weeks' gestation, with plasma ferritin and soluble transferrin receptor (sTfR) measurements. Iron status was determined according to plasma ferritin concentrations at ≥30 µg/L (iron sufficiency), 15 to < 30 µg/L (modest iron depletion) and < 15 µg/L (severe iron depletion). Multivariable ordinal logistic regression was used to analyze risk factors for modest and severe iron depletion. RESULTS: The median (25-75th percentile) plasma ferritin concentration was 24.2 (19.9-30.6) µg/L. Overall, 660 (67.0%) and 67 (6.8%) women had modest and severe iron depletion, respectively. Higher plasma sTfR was observed in women with severe iron depletion than among those with iron sufficiency (median 17.6 versus 15.5 nmol/L; p < 0.001). Age < 25 years (odds ratio 2.36; 95% confidence interval 1.15-4.84), Malay (2.05; 1.30-3.24) and Indian (1.98; 1.14-3.44) ethnicities (versus Chinese), university qualification (1.64; 1.13-2.38), multiparity (1.73; 1.23-2.44) and lack of iron-containing supplementation (3.37; 1.25-8.53) were associated with increased odds of modest and severe iron depletion. CONCLUSIONS: Nearly three-quarters of Singaporean women were iron deficient in the early third trimester of pregnancy. These results suggest universal screening and supplementation of at-risk pregnancies may be evaluated as a preventive strategy. TRIAL REGISTRATION: NCT01174875 . Registered 1 July 2010 (retrospectively registered).


Assuntos
Anemia Ferropriva/epidemiologia , Ferritinas/sangue , Ferro na Dieta/administração & dosagem , Complicações Hematológicas na Gravidez/epidemiologia , Adulto , Anemia Ferropriva/sangue , Anemia Ferropriva/diagnóstico , Biomarcadores/sangue , Estudos de Coortes , Estudos Transversais , Feminino , Humanos , Ferro/sangue , Gravidez , Complicações Hematológicas na Gravidez/sangue , Complicações Hematológicas na Gravidez/diagnóstico , Terceiro Trimestre da Gravidez , Estudos Prospectivos , Receptores da Transferrina/sangue , Fatores de Risco , Singapura , Adulto Jovem
14.
BMC Res Notes ; 12(1): 127, 2019 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-30867036

RESUMO

OBJECTIVES: Our study aimed to assess local data for compliance with IFA supplementation and prevalence of anaemia among the pregnant mothers visiting government health facilities of eastern Nepal. RESULTS: In our study samples, IFA compliance rate was 58% during pregnancy and 42% were anaemic. Anemia was 24 times more likely to occur in IFA noncompliant women during pregnancy than their counterparts (aOR = 24.2, 95% CI 10.1-58.3), and anemia was three times less likely to be found in those taking foods rich in heme-iron than their counterparts (aOR = 3.3, 95% CI 1.4-8.1).


Assuntos
Anemia/prevenção & controle , Dieta/estatística & dados numéricos , Suplementos Nutricionais/estatística & dados numéricos , Ácido Fólico/administração & dosagem , Hospitais Públicos/estatística & dados numéricos , Ferro/administração & dosagem , Adesão à Medicação/estatística & dados numéricos , Complicações Hematológicas na Gravidez/prevenção & controle , Oligoelementos/administração & dosagem , Complexo Vitamínico B/administração & dosagem , Adolescente , Adulto , Anemia/epidemiologia , Estudos Transversais , Feminino , Humanos , Nepal/epidemiologia , Gravidez , Complicações Hematológicas na Gravidez/epidemiologia , Adulto Jovem
15.
Enferm. clín. (Ed. impr.) ; 29(supl.1): 94-97, mar. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-184782

RESUMO

Low birthweight is one of the risk factors that contribute to infant mortality especially during perinatal period. Low birthweight is still a worldwide problem because it is a newborn's death. in essence many factors that affect the incidence of low birthweight they are maternal age and anemia. The purpose of this study is to analyze the maternal age and anemia are risk factors of low birthweight newborn. This research is an analytic observational study with case control study. The sample of this study amounted to 32 cases and 32 controls. The instrument used observation sheet by looking at the data in Medical Record. The analysis used is bivariate with person chi-square test to see the maternal age and anemia are risk factors of low birthweight newborn. The result of this study proved maternal age affect as low birthweight newborn, evidenced by statistic analysis p-value < 0.05 is 0.001 and Odd Ratio: 16.2 (Confident Interval 95%: 1.94-135.38), and anemia affect as low birthweight newborn, evidenced by statistic analysis p-value < 0.05 is 0.001 and Odd Ratio: 6.3 (Confident Interval 95%: 3-13.198). The results of this study can be concluded that maternal age and anemia have affect of low birthweight newborn


No disponible


Assuntos
Humanos , Gravidez , Recém-Nascido , Adulto Jovem , Adulto , Anemia/epidemiologia , Recém-Nascido de Baixo Peso , Idade Materna , Complicações Hematológicas na Gravidez/epidemiologia , Estudos de Casos e Controles , Fatores de Risco
16.
Enferm Clin ; 29 Suppl 1: 94-97, 2019 03.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-30755354

RESUMO

Low birthweight is one of the risk factors that contribute to infant mortality especially during perinatal period. Low birthweight is still a worldwide problem because it is a newborn's death. in essence many factors that affect the incidence of low birthweight they are maternal age and anemia. The purpose of this study is to analyze the maternal age and anemia are risk factors of low birthweight newborn. This research is an analytic observational study with case control study. The sample of this study amounted to 32 cases and 32 controls. The instrument used observation sheet by looking at the data in Medical Record. The analysis used is bivariate with person chi-square test to see the maternal age and anemia are risk factors of low birthweight newborn. The result of this study proved maternal age affect as low birthweight newborn, evidenced by statistic analysis p-value <0.05 is 0.001 and Odd Ratio: 16.2 (Confident Interval 95%: 1.94-135.38), and anemia affect as low birthweight newborn, evidenced by statistic analysis p-value <0.05 is 0.001 and Odd Ratio: 6.3 (Confident Interval 95%: 3-13.198). The results of this study can be concluded that maternal age and anemia have affect of low birthweight newborn.


Assuntos
Anemia , Recém-Nascido de Baixo Peso , Idade Materna , Complicações Hematológicas na Gravidez , Adulto , Anemia/epidemiologia , Estudos de Casos e Controles , Feminino , Humanos , Recém-Nascido , Gravidez , Complicações Hematológicas na Gravidez/epidemiologia , Fatores de Risco , Adulto Jovem
17.
PLoS One ; 14(2): e0211114, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30811416

RESUMO

OBJECTIVES: To investigate the incidence of inherited thrombophilias in patients with adverse obstetric outcomes and to compare detection rates of thrombophilias between standard blood tests and a novel genetic test. METHODS: This is a case-control prospective study performed in Hospital Sant Joan de Déu in Barcelona, Spain. Cases had a history of intrauterine growth restriction requiring delivery before 34 weeks gestation, placental abruption before 34 weeks gestation, or severe preeclampsia. Controls had at least two normal, spontaneously conceived pregnancies at term, without complications or no underlying medical disease. At least 3 months after delivery, all case and control women underwent blood collection for standard blood tests for thrombophilias and saliva collection for the genetic test, which enables the diagnosis of 12 hereditary thrombophilias by analyzing genetic variants affecting different points of the blood coagulation cascade. RESULTS: The study included 33 cases and 41 controls. There were no statistically significant differences between cases and controls in the standard blood tests for thrombophilias in plasma or the TiC test for genetic variables. One clinical-genetic model was generated using variables with the lowest P values: ABO, body mass index, C_rs5985, C_rs6025, and protein S. This model exhibited good prediction capacity, with an area under the curve of almost 0.7 (P <0.05), sensitivity of almost 67%, and specificity of 70%. CONCLUSION: Although some association may exist between hypercoagulability and pregnancy outcomes, no significant direct correlation was observed between adverse obstetric outcomes and inherited thrombophilias when analyzed using either standard blood tests or the genetic test. Future studies with a larger sample size are required to create a clinical-genetic model that better discriminates women with a history of adverse pregnancy outcomes and an increased risk of poor outcomes in subsequent pregnancies.


Assuntos
Complicações Hematológicas na Gravidez/genética , Trombofilia/complicações , Trombofilia/genética , Descolamento Prematuro da Placenta/genética , Adulto , Estudos de Casos e Controles , Feminino , Retardo do Crescimento Fetal/genética , Testes Genéticos , Humanos , Incidência , Recém-Nascido , Pessoa de Meia-Idade , Pré-Eclâmpsia/genética , Gravidez , Complicações Hematológicas na Gravidez/diagnóstico , Complicações Hematológicas na Gravidez/epidemiologia , Resultado da Gravidez , Estudos Prospectivos , Medição de Risco , Fatores de Risco , Espanha/epidemiologia , Trombofilia/epidemiologia , Adulto Jovem
18.
Int Q Community Health Educ ; 39(3): 155-161, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30596326

RESUMO

We explored management and prevention practices concerning anemia in pregnancy (AIP) in Anambra State, Nigeria from a cross-sectional survey of 600 women of child-bearing age through a multistage random selection process. The objective is to identify factors that influence recognition and management of AIP. A knowledge index of 45 points was developed with the mean score of 5.9 points (5.9 ± 6.1 SD). Furthermore, 49.3% of the respondents had good knowledge. The urban respondents had good knowledge (66.7%) compared with their rural counterparts (32%). There were misconceptions on the causes, management, and prevention of AIP during pregnancy. Multiple regression analyses revealed that variables such as religious affiliation, education, and residence influenced the knowledge about AIP. A unit increase in the educational level of the women will bring about 0.644 units of increase in the knowledge of AIP ( p = .003). A unit change from urban to rural locality would lead to 1.536 units increase in correct practices to prevent AIP ( p < .001). A unit change to being married would lead to 0.936 unit increase in correct practices to prevent AIP ( p = .025). Knowledge about the management and prevention of AIP was poor. Anemia-related education to improve knowledge and practice should be provided during antenatal care. Living in an urban community was associated with the odds ratio of 4.3 (95% CI [3.07, 6.07]) and 7.42 (95% CI [2.0, 27.6]) for knowledge and prevention of AIP, respectively.


Assuntos
Anemia/epidemiologia , Conhecimentos, Atitudes e Prática em Saúde , Complicações Hematológicas na Gravidez/epidemiologia , Adolescente , Adulto , Estudos Transversais , Feminino , Acesso aos Serviços de Saúde , Humanos , Pessoa de Meia-Idade , Nigéria , Educação de Pacientes como Assunto , Gravidez , Cuidado Pré-Natal , Análise de Regressão , Características de Residência , Fatores Socioeconômicos , Adulto Jovem
19.
BJOG ; 126(6): 737-743, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30554474

RESUMO

OBJECTIVE: To describe the association of maternal anaemia with maternal, fetal, and neonatal outcomes. DESIGN: Prospective cohort study. SETTING: Rural India and Pakistan. POPULATION: Pregnant women residing in the study catchment area. METHODS: We performed an analysis of a prospective pregnancy registry in which haemoglobin is commonly obtained as well as maternal, fetal, and neonatal outcomes for 42 days post-delivery. Women 40 years or older who delivered before 20 weeks or had a haemoglobin level of <3.0 g/dl were excluded. Our primary exposure was maternal anaemia, which was categorised in keeping with World Health Organization criteria based on a normal (≥11 g/dl), mild (>10-10.9 g/dl), moderate (7-9.9 g/dl) or severe (<7 g/dl). haemoglobin level. The primary maternal outcome was maternal death, the primary fetal outcome was stillbirth, and the primary neonatal outcome was neonatal mortality <28 days. RESULTS: A total of 92 247 deliveries and 93 107 infants were included, of which 87.8% were born to mothers who were anaemic (mild 37.9%, moderate 49.1%, and severe 0.7%). Maternal mortality (number per 100 000) was not associated with anaemia: normal 124, mild 106, moderate 135, and severe 325 (P = 0.64). Fetal and neonatal mortality was associated with severe anaemia: stillbirth rate (n/1000)-normal 27.7, mild 25.8, moderate 30.1, and severe 90.9; P < 0.0001; 28-day neonatal mortality (n/1000)-normal 24.7, mild 22.9, moderate 28.1, and severe 72.6 (P < 0.0001). Severe maternal anaemia was also associated with low birthweight (<2500 and <1500 g), preterm birth, and postpartum haemorrhage. CONCLUSION: Severe maternal anaemia is associated with higher risks of poor maternal, fetal, and neonatal outcomes but other degrees of anaemia are not. Interventions directed at preventing severe anaemia in pregnant women should be considered. TWEETABLE ABSTRACT: Severe maternal anaemia is associated with adverse fetal and neonatal outcomes in low/middle-income countries.


Assuntos
Anemia , Hemorragia Pós-Parto , Complicações Hematológicas na Gravidez , Nascimento Prematuro , Cuidado Pré-Natal , Adulto , Anemia/sangue , Anemia/complicações , Anemia/diagnóstico , Anemia/epidemiologia , Estudos de Coortes , Feminino , Humanos , Índia/epidemiologia , Lactente , Mortalidade Infantil , Recém-Nascido , Mortalidade Materna , Paquistão/epidemiologia , Hemorragia Pós-Parto/diagnóstico , Hemorragia Pós-Parto/epidemiologia , Gravidez , Complicações Hematológicas na Gravidez/sangue , Complicações Hematológicas na Gravidez/diagnóstico , Complicações Hematológicas na Gravidez/epidemiologia , Resultado da Gravidez/epidemiologia , Nascimento Prematuro/epidemiologia , Nascimento Prematuro/prevenção & controle , Cuidado Pré-Natal/métodos , Cuidado Pré-Natal/estatística & dados numéricos , Estudos Prospectivos , Natimorto
20.
J Matern Fetal Neonatal Med ; 32(10): 1728-1734, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-29183181

RESUMO

OBJECTIVE: Anemia is a major public health and nutritional problem in the world. Studies have reported the relationship between anemia during pregnancy and small for gestational age (SGA). Therefore, the present systematic review and meta-analysis was conducted to determine the relationship between maternal anemia during pregnancy and SGA. METHOD: This meta-analysis was conducted without time limit until April 2017 based on the PRISMA protocol. Several international databases including Cochrane, Scopus, Web of Science (ISI), Pubmed, Embase, and Google Scholar search engine were searched independently by two researchers. The keywords include: anemia, pregnant women, gestational age, and pregnancy. The relative risk (RR) and 95% confidence interval were estimated regarding to the significance of the I2 index based on the random effects model. Data were analyzed using Comprehensive Meta-Analysis Software version 2. RESULTS: Ten studies with a sample size including 620 080 pregnant women entered the meta-analysis process. The overall relationship between maternal anemia during pregnancy and SGA was not significant (RR = 1.11 [95%CI: 0.99-1.24, p = .074]). The relationship between anemia during pregnancy and SGA based on pregnancy trimester showed that maternal anemia was significant in the first trimester, (RR = 1.11 [95%CI: 1-1.22, p = .044]), but this relationship was not significant in the second trimester (RR = 1.11 [95%CI: 0.85-1.18, p = .91]). CONCLUSIONS: Maternal anemia in the first trimester of pregnancy can be considered as a risk factor for negative pregnancy outcomes (SGA).


Assuntos
Anemia Ferropriva/fisiopatologia , Recém-Nascido Pequeno para a Idade Gestacional , Complicações Hematológicas na Gravidez/epidemiologia , Anemia Ferropriva/epidemiologia , Estudos de Coortes , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Gravidez , Complicações Hematológicas na Gravidez/fisiopatologia , Primeiro Trimestre da Gravidez , Segundo Trimestre da Gravidez
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA