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1.
Medicine (Baltimore) ; 99(1): e18298, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31895768

RESUMO

INTRODUCTION: Leptomeningeal dissemination due to HER2-overexpressing breast cancer is a rare and hard to treat complication with short-term dismal prognosis. PATIENT CONCERNS: A 34-year-old female previously treated because of HER2+ breast cancer is admitted to the Neurology Department in December 2016 due to sensory-motor neurological semiology. DIAGNOSIS: A wide set of diagnostic tests is performed and finally cytologic findings after repeated CSF confirm leptomeningeal infiltration by breast carcinoma (panCK+, GATA3+). INTERVENTIONS: Weekly intrathecal triple therapy with methotrexate, cytarabine and hydrocortisone plus trastuzumab is carried out during 4 months. OUTCOMES: Clinical and pathological response that lasts more than 24 months. CONCLUSION: Leptomeningeal carcinomatosis is an oncological situation where conventional therapies have limited activity. In HER2+ advanced breast cancer patients, intrathecal therapy with anti-HER2 therapy (trastuzumab) is feasible and may reach long-term disease control, especially in cases of low-tumor burden.


Assuntos
Antineoplásicos Imunológicos/uso terapêutico , Neoplasias da Mama/patologia , Carcinoma Ductal/patologia , Carcinomatose Meníngea/tratamento farmacológico , Carcinomatose Meníngea/secundário , Trastuzumab/uso terapêutico , Adulto , Neoplasias da Mama/tratamento farmacológico , Carcinoma Ductal/tratamento farmacológico , Feminino , Humanos , Carcinomatose Meníngea/patologia , Gravidez , Complicações Neoplásicas na Gravidez/tratamento farmacológico , Complicações Neoplásicas na Gravidez/patologia , Receptor ErbB-2
2.
Pan Afr Med J ; 33: 202, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692775

RESUMO

Cavernous haemangiomas are benign vascular malformations that can locate in the central nervous system. The epidural spinal location remains unusual. Pregnancy is known to be a precipitating factor. The aim of this study is to review general aspects of these lesions and specific facts about their relationship to pregnancy. A 32-year-old full-term pregnant woman is managed during early labor for a progressive spinal cord compression syndrome. After delivery, exploration by a lumbar MRI found an epidural vascular dorsal mass. Surgical exploration and histopathological examination confirmed the diagnosis of epidural cavernous haemangioma. The patient achieved complete recovery after 1 month. Spinal cavernous haemangiomas are rare malformations. Specific mechanisms seems to be involved in their growth during pregnancy. Although clinical and radiological presentation are spectacular and misleading, the prognosis is generally good, and urgent surgical treatment during pregnancy is usually not indicated.


Assuntos
Neoplasias Epidurais/diagnóstico , Hemangioma Cavernoso do Sistema Nervoso Central/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Adulto , Neoplasias Epidurais/patologia , Neoplasias Epidurais/cirurgia , Feminino , Hemangioma Cavernoso do Sistema Nervoso Central/patologia , Hemangioma Cavernoso do Sistema Nervoso Central/cirurgia , Humanos , Imagem por Ressonância Magnética , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Complicações Neoplásicas na Gravidez/cirurgia , Prognóstico , Compressão da Medula Espinal/etiologia
4.
BMJ Case Rep ; 12(8)2019 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-31383683

RESUMO

Uterine leiomyosarcoma (ULMS) is a highly malignant neoplasm which has been rarely described in pregnancy. A case of advanced metastatic ULMS presenting at 26 weeks gestation is reported. The principles in managing invasive cancer in pregnancy are discussed.


Assuntos
Leiomiossarcoma/patologia , Complicações Neoplásicas na Gravidez/patologia , Neoplasias Uterinas/patologia , Adulto , Evolução Fatal , Feminino , Humanos , Gravidez , Segundo Trimestre da Gravidez
5.
Pan Afr Med J ; 33: 36, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31384351

RESUMO

We present a case of Meigs syndrome in a 19 year old woman. We suspected metastatic ovarian cancer after she had presented in her first pregnancy at 12 weeks gestation. Ultrasound scan had confirmed a complex solid mass in the left adnexa, measuring 7cm x 8cm, a viable 12 weeks pregnancy and gross ascites. She had elevated Ca 125 and serum beta - HCG. She went on to have a spontaneous miscarriage while being worked up for exploratory laparotomy. At laparotomy, a left sided solid ovarian mass 8cm x 10cm with a smooth surface and intact capsule was found. This was later confirmed to be a fibrothecoma at histology. The patient went on to recover without any further reaccumulation of ascites.


Assuntos
Síndrome de Meigs/diagnóstico , Neoplasias Ovarianas/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Aborto Espontâneo/etiologia , Ascite/diagnóstico , Ascite/patologia , Antígeno Ca-125/sangue , Feminino , Humanos , Laparotomia/métodos , Síndrome de Meigs/patologia , Neoplasias Ovarianas/patologia , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Ultrassonografia/métodos , Adulto Jovem
6.
BMC Womens Health ; 19(1): 100, 2019 07 22.
Artigo em Inglês | MEDLINE | ID: mdl-31331317

RESUMO

BACKGROUND: Uterine leiomyomas are often discovered during early pregnancy and in most cases will have no effect on pregnancy outcomes. However, in rare cases uterine leiomyomas may lead to obstetric complications. The aim of the study was to evaluate rate of uterine leiomyoma growth in the 3 trimesters of pregnancy. METHODS: We conducted a retrospective cohort study. Included were women who were diagnosed with uterine leiomyoma during pregnancy and had at least two sonographic measurements in different trimesters. Data regarding leiomyoma growth, recorded by ultrasound examination, during 1st 2nd and 3rd trimesters were collected from electronic patient records. RESULTS: Two-hundred forty-eight uterine leiomyomas were included in the study. Leiomyoma area increased substantially in size between the 1st and 2nd trimesters (54.5% ± 75.9%, p = .007) and to a lesser degree between the 2nd and 3rd trimesters (17.9% ± 59.7%, NS). Evaluation of the change in size throughout the pregnancy - between 1st and 3rd trimesters revealed a significant increase of 95.9% ± 191.3% (p < .001). There was no significant growth of the leiomyomas between the 2nd and 3rd trimesters. CONCLUSIONS: Uterine leiomyomas tend to grow substantially during the 1st trimester of pregnancy. This trend is attenuated later with minimal growth towards the end of gestation.


Assuntos
Leiomioma/patologia , Complicações Neoplásicas na Gravidez/patologia , Trimestres da Gravidez , Neoplasias Uterinas/patologia , Adulto , Feminino , Humanos , Leiomioma/diagnóstico por imagem , Pessoa de Meia-Idade , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico por imagem , Resultado da Gravidez , Primeiro Trimestre da Gravidez , Segundo Trimestre da Gravidez , Terceiro Trimestre da Gravidez , Estudos Retrospectivos , Carga Tumoral , Ultrassonografia , Neoplasias Uterinas/diagnóstico por imagem , Adulto Jovem
7.
Cien Saude Colet ; 24(6): 2361-2369, 2019 Jun 27.
Artigo em Português, Inglês | MEDLINE | ID: mdl-31269192

RESUMO

The prevalence of gestational breast cancer (GBC) is 1:3,000-10,000 pregnancies. This study aims to identify the risk factors associated with GBC. This case-control study was conducted in the period between January 2004 and December 2014 at a reference maternity hospital for high-risk pregnancies in Rio de Janeiro. Two controls were selected for each case, totaling 21 GBC cases and 42 controls. Data were collected through a review of medical and hospitalization and delivery records. Reproductive, obstetrical, sociodemographic and health-related characteristics were investigated. Results: The mean age of pregnant women in both groups was 35.5 years. Menarche's mean age was also similar (12.3 years) in both groups. Mother's age at first pregnancy was > 30 years in 28.6% of the patients with GBC and in 2.4% of the control group (p = 0.03). Crude and adjusted odds ratio and their respective CI 95% were calculated through conditional logistic regression paired by mother's age. The results show that the risk for GBC increases 27% for each additional year of mother's age at first pregnancy (p < 0.02) and that mothers with lower schooling had higher risk of GBC (OR = 8.49). Conclusion: Our data confirm the association of primiparity over 30 years of age and low level of schooling with GBC.


Assuntos
Neoplasias da Mama/epidemiologia , Idade Materna , Complicações Neoplásicas na Gravidez/epidemiologia , Adulto , Brasil , Estudos de Casos e Controles , Escolaridade , Feminino , Humanos , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Prevalência , Fatores de Risco
8.
Dermatol Online J ; 25(5)2019 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-31220902

RESUMO

Dermatofibromas are common and asymptomatic benign histiocytic tumors. The occurrence in a small number (up to 5 lesions) is frequent. However, the expression "multiple eruptive dermatofibromas" is reserved for the appearance of more than 5 lesions in less than four months. Multiple eruptive dermatofibromas are rare and usually associated with an underlying systemic condition, the most common being autoimmune diseases or HIV infection. Herein we report multiple eruptive dermatofibromas developing in an otherwise healthy pregnant woman. Although the pathogenesis of this condition remains unknown, it is believed to be related to immunological alterations, given the strong association with states of immunosuppression or, in the case of pregnancy, with a state of immunotolerance.


Assuntos
Histiocitoma Fibroso Benigno/patologia , Complicações Neoplásicas na Gravidez/patologia , Neoplasias Cutâneas/patologia , Adulto , Feminino , Histiocitoma Fibroso Benigno/imunologia , Humanos , Tolerância Imunológica , Gravidez , Complicações Neoplásicas na Gravidez/imunologia , Neoplasias Cutâneas/imunologia
9.
Anticancer Res ; 39(5): 2627-2631, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31092461

RESUMO

BACKGROUND/AIM: Pineoblastoma of the adult age is an uncommon tumor with only 200 cases reported. A standardized approach for an optimal adjuvant strategy is currently lacking. The case presented herein also deals with the issue of central nervous system tumors in pregnancy. CASE REPORT: A 21-year-old pregnant woman presented with massive hydrocephalus due to a mass in the pineal region detected with MRI. After positioning an urgent ventricular derivation, a cesarean section was performed. During a third ventriculocisternostomy, a biopsy revealed a pineoblastoma. After a maximal safe resection, postoperative craniospinal irradiation for a total dose of 36 Gy plus a sequential boost to the tumor bed to 54 Gy, and adjuvant chemotherapy with CDDP plus CCNU plus vincristine were performed. After one year, the patient is alive with no evidence of disease. CONCLUSION: The use of adjuvant radio-chemotherapy provided excellent outcomes in our case. The advanced gestational age facilitated the choice of the therapeutic strategy.


Assuntos
Quimiorradioterapia Adjuvante , Glândula Pineal/diagnóstico por imagem , Pinealoma/radioterapia , Complicações Neoplásicas na Gravidez/radioterapia , Adulto , Cesárea , Feminino , Humanos , Imagem por Ressonância Magnética , Glândula Pineal/fisiopatologia , Glândula Pineal/cirurgia , Pinealoma/diagnóstico por imagem , Pinealoma/tratamento farmacológico , Pinealoma/fisiopatologia , Gravidez , Complicações Neoplásicas na Gravidez/tratamento farmacológico , Complicações Neoplásicas na Gravidez/patologia , Resultado do Tratamento , Ventriculostomia
10.
BMJ Case Rep ; 12(5)2019 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-31110067

RESUMO

Wunderlich's syndrome, non-traumatic renal haemorrhage into the subscapular and perinephric space, in pregnancy, is a very rare clinical entity. We describe a case of Wunderlich's syndrome in a 29-year-old gravida 5 para 4 who presented to our emergency department with sudden onset severe left flank pain. On assessment, she was clinically shocked-hypotensive, tachycardic and perfused poorly peripherally. Ultrasound of the abdomen and pelvis and subsequent MRI of the left kidney revealed a large hypervascular exophytic lesion arising from the left renal pole-appearance consistent with an angiomyolipoma. This specific presentation is clinically characterised as Lenk's triad-acute flank pain, flank mass and hypovolaemic shock. The patient was adequately resuscitated and interventional radiological embolisation of the mass was performed. She went on to have an uneventful pregnancy and delivered vaginally after induction at 38 weeks of gestation.


Assuntos
Angiomiolipoma/patologia , Neoplasias Renais/patologia , Complicações Neoplásicas na Gravidez/patologia , Adulto , Angiomiolipoma/diagnóstico por imagem , Angiomiolipoma/cirurgia , Parto Obstétrico , Feminino , Dor no Flanco/etiologia , Humanos , Neoplasias Renais/diagnóstico por imagem , Neoplasias Renais/cirurgia , Imagem por Ressonância Magnética , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico , Complicações Neoplásicas na Gravidez/cirurgia , Choque Hemorrágico/etiologia , Síndrome
11.
BMC Womens Health ; 19(1): 69, 2019 05 23.
Artigo em Inglês | MEDLINE | ID: mdl-31122220

RESUMO

BACKGROUND: We encountered a woman with vaginal cancer that was associated with complete uterine prolapse and complicated by severe intrauterine adhesions. In this case report, we describe the clinical course and successful treatment of this rare condition. CASE PRESENTATION: A 78-year-old woman (gravida 10, para 2, abortion 8) with a 10-year history of uterine prolapse presented for evaluation of bleeding from an ulceration on the surface of the irreducibly prolapsed uterus. Biopsy of a mass on her vaginal wall led to a diagnosis of keratinizing squamous cell carcinoma. Her history of eight abortion procedures had resulted in severe intrauterine adhesions, preventing tandem insertion and intracavitary brachytherapy. She was also ineligible for surgery under general anesthesia + chemotherapy because of her advanced age and presence of arrhythmia. Therefore, we devised an extensive treatment plan involving high-dose-rate interstitial brachytherapy. This treatment successfully eliminated the squamous cell carcinoma as confirmed by biopsy with no recurrence or severe late complications. CONCLUSIONS: We found that high-dose-rate interstitial brachytherapy may be a very effective therapeutic strategy for this condition with few adverse effects.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Complicações Neoplásicas na Gravidez/cirurgia , Prolapso Uterino/cirurgia , Neoplasias Vaginais/cirurgia , Idoso , Braquiterapia , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Recidiva Local de Neoplasia , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Prolapso Uterino/complicações , Neoplasias Vaginais/complicações
12.
Niger J Clin Pract ; 22(4): 578-581, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30975966

RESUMO

Mature cystic teratoma is the most common ovarian neoplasm. However, mucinous cystadenoma with teratoma has been very rarely reported in literature. This case report, which is very rare, describes a clinical entity not previously reported in literature. A 34-year-old pregnant woman presented in the 23rd gestational week with severe right lower quadrant pain. She was diagnosed with acute abdomen and was then treated surgically. During the surgical intervention, a spontaneously ruptured mass was detected in the right ovary. This was reported histopathologically as a mature cystic teratoma in collision with mucinous cystadenoma. To the best of our knowledge, this case report is the first to have identified a ruptured mature cystic teratoma in collision with mucinous cystadenoma in a pregnant woman.


Assuntos
Cistadenoma Mucinoso/cirurgia , Neoplasias Ovarianas/cirurgia , Complicações Neoplásicas na Gravidez/cirurgia , Teratoma/cirurgia , Adulto , Cistadenoma Mucinoso/patologia , Feminino , Humanos , Neoplasias Ovarianas/patologia , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Teratoma/patologia , Resultado do Tratamento
13.
Eur J Obstet Gynecol Reprod Biol ; 236: 173-176, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30933887

RESUMO

OBJECTIVE: To investigate the clinical outcome of high-grade cervical intraepithelial neoplasia (CIN) diagnosed by colposcopy-directed biopsy during pregnancy and to evaluate the risk factors for persistent disease. STUDY DESIGN: This retrospective study included pregnant women who were diagnosed with CIN2+ by colposcopy-directed biopsy from January 2005 to December 2014. The clinical characteristics, histopathologic results, and human papillomavirus (HPV) test results were reviewed. The final histopathologic result after delivery was compared with the initial diagnosis to determine disease progression, persistence, or regression. RESULTS: During the 10-year period, 215 pregnant women were diagnosed with high-grade CIN (75 CIN2, 140 CIN3) by colposcopy-directed biopsy. The mean age of the patients was 30.4 years. A total of 187 patients (87.0%) had high-risk HPV infections, with 76 (35.3%) infections identified as HPV genotype 16 or 18. Excisional procedures for diagnosis and treatment were not performed during pregnancy. The histopathologic results of 160 patients (normal in 43, CIN1 in 10, CIN2 in 15, CIN3 in 89, and invasive cancer in 3) were evaluated during the postpartum period. Multivariate logistic regression analysis was performed, and postpartum high-risk HPV infection (OR 5.09; 95% CI 2.15-12.05; P < 0.001) was identified as a significant independent predictor of CIN2+ persistence. CONCLUSIONS: Conservative management of CIN2-3 during pregnancy is acceptable. However, persistent high-risk HPV infection is a major risk factor for CIN2+ persistence. Close follow-up with HPV testing, and postpartum colposcopy evaluation are necessary.


Assuntos
Neoplasia Intraepitelial Cervical/diagnóstico , Infecções por Papillomavirus/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Adulto , Biópsia , Neoplasia Intraepitelial Cervical/patologia , Neoplasia Intraepitelial Cervical/virologia , Colposcopia , Progressão da Doença , Feminino , Humanos , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/patologia , Infecções por Papillomavirus/virologia , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Complicações Neoplásicas na Gravidez/virologia , Estudos Retrospectivos , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/virologia , Adulto Jovem
14.
Ann Clin Lab Sci ; 49(1): 94-96, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30814083

RESUMO

Acute promyelocytic leukemia during pregnancy is associated with a high risk of fetal and obstetrical complications. Although the prognosis of acute promyelocytic leukemia is favorable due to disease-specific drugs, such as all-trans retinoic acid, early death due to fatal intracranial hemorrhage has been observed in some cases. In this study, we present a case of catastrophic intracranial hemorrhage in a young pregnant patient with the finding of leukemic involvement of the placenta. To our knowledge, this is the first confirmed case of acute promyelocytic leukemia involving the placenta. The clinical history, pertinent histological findings, and clinical outcomes will be discussed.


Assuntos
Hemorragias Intracranianas/patologia , Leucemia Promielocítica Aguda/complicações , Complicações Neoplásicas na Gravidez/patologia , Adulto , Evolução Fatal , Feminino , Humanos , Hemorragias Intracranianas/etiologia , Gravidez , Complicações Neoplásicas na Gravidez/etiologia , Adulto Jovem
15.
Pak J Pharm Sci ; 32(1(Special)): 421-426, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30852479

RESUMO

At present, the main methods of clinical treatment of ovarian cancer are cytoreductive surgery and multidrug combination chemotherapy, in which multidrug combination chemotherapy is based on platinum drugs. Mifepristone can be used as an adjuvant drug for the treatment of drug-resistant and refractory ovarian cancer because of its convenient oral administration, long half-life, low cytotoxicity to normal cells, anti-tumor activity and chemosensitizing effect. This article analyzed the clinical effect of mifepristone combined with bevacizumab in the treatment of patients with ovarian cancer. Sixty patients were randomly divided into experimental group and control group. Mifepristone combined with bevacizumab was used in experimental group and conventional anticancer drugs were used in control group. The results showed that the amount of bleeding during labor (6.38±1.85 mL), the rate of birth injury (0%) and the amount of bleeding 2 hours after delivery (63.12±19.86 mL) in the experimental group were significantly better than those in the control group (P<0.05), and the incidence of side effects and complications were significantly lower than those in the control group (P<0.05). In conclusion, mifepristone combined with bevacizumab in the treatment of high-risk pregnancy complicated with ovarian cancer can significantly reduce the patient's labor process and the amount of bleeding at different stages after surgery, the incidence of side effects and complications after surgery is significantly reduced, which is conducive to the recovery of the patient's body. .


Assuntos
Adenocarcinoma/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Bevacizumab/uso terapêutico , Mifepristona/uso terapêutico , Neoplasias Ovarianas/tratamento farmacológico , Complicações Neoplásicas na Gravidez/tratamento farmacológico , Adenocarcinoma/patologia , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Bevacizumab/administração & dosagem , Bevacizumab/efeitos adversos , Quimioterapia Adjuvante , Feminino , Humanos , Mifepristona/administração & dosagem , Mifepristona/efeitos adversos , Estadiamento de Neoplasias , Neoplasias Ovarianas/patologia , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Resultado da Gravidez , Gravidez de Alto Risco
16.
Gynecol Endocrinol ; 35(7): 567-570, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30786782

RESUMO

Paragangliomas are tumors that originate from the extra-adrenal neural crest, the incidence of which during pregnancy is not more than two to eight cases per million people per year and are known to be highly morbid. The purpose of this report is to describe the experience and results obtained during management of a primigravida diagnosed with paraganglioma on week 21.2 and received both medical and surgical management with good maternal and perinatal outcomes. This case report evidences the importance of practicing interdisciplinary management of patients with clinical suspicion of paragangliomas or pheochromocytomas during pregnancy at high-complexity centers even in a medium-income country.


Assuntos
Neoplasias das Glândulas Suprarrenais/cirurgia , Paraganglioma/cirurgia , Complicações Neoplásicas na Gravidez/cirurgia , Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem , Neoplasias das Glândulas Suprarrenais/patologia , Feminino , Humanos , Imagem por Ressonância Magnética , Paraganglioma/diagnóstico por imagem , Paraganglioma/patologia , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico por imagem , Complicações Neoplásicas na Gravidez/patologia , Resultado do Tratamento , Adulto Jovem
17.
J Otolaryngol Head Neck Surg ; 48(1): 9, 2019 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-30717781

RESUMO

BACKGROUND: Malignancies occur in approximately 1:1000 pregnancies; the most common being breast (46%) and hematological (18%) malignancies. Oral cancers account for only 2% of all cancers in pregnant women, and there are no standard guidelines for the treatment of oral cancer during pregnancy. METHODS: Between 2007 and 2014, our department managed 1109 patients with oral cancers; four (0.4%) had tongue carcinomas during pregnancy. These cases were retrospectively reviewed. RESULTS: The four women were aged 29-39 (median 32.5) years. Two underwent partial glossectomy at 39 and 40 weeks' gestation, respectively, one received radiotherapy at 17 weeks' gestation, and one underwent supraomohyoid neck dissection and hemi-glossectomy with a forearm flap reconstruction. CONCLUSION: In addition to tumor factors, the wishes of the patient and her family, gestational age, and fetal and maternal conditions are important factors in deciding on a treatment protocol. Moreover, treatment decisions require multidisciplinary approach.


Assuntos
Carcinoma/terapia , Neoplasias Bucais/terapia , Complicações Neoplásicas na Gravidez/terapia , Adulto , Carcinoma/patologia , Feminino , Glossectomia , Humanos , Neoplasias Bucais/patologia , Esvaziamento Cervical , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Resultado da Gravidez , Estudos Retrospectivos
19.
Asian Pac J Cancer Prev ; 20(1): 135-138, 2019 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-30678424

RESUMO

Introduction: Pregnancy Associated Breast cancer (PABC) is associated with poor prognosis and a decreased overall survival. A retrospective review was conducted to review the experience and outcome in a tertiary care hospital, and to compare those seen in a matched group for year of diagnosis. Materials and Methods: This is a retrospective review of a prospectively collected breast cancer registry. The study was conducted in a tertiary care hospital in Riyadh, Saudi Arabia from January to Decamber 2014 . Female patients with PABC were identified and matched with similar cohort of non-pregnant breast cancer patients that were diagnosed between 2001-2010. Clinical data including age, tumor biology, clinical stage, follow up and outcomes (disease free survival, DFS) were analyzed and compared between the two groups using SAS 9.3 and R-2.14.1 Results: A total of 110 patients in Group 1 and 114 patients in Group II were analyzed. In both groups, the patient age ranged was between 20 to 45 years; the median follow up was 34 months in PABC and 54 months in non-pregnant cohort. PABC were statistically more likely to be triple negative (p value-0.05) and diagnosed at advanced stage (stage 3 and 4) (p value-0.02). There was no difference in the occurrence of Her-2 positive disease. In pregnant patients there was a 5-year survival rate of 65% compared to non-pregnant cohort of 82% with p value of 0.002 and DFS was also 47.5% versus 65.4% with a p value .002 which is statistically significant. Conclusion: Pregnancy associated breast cancer (PABC) is diagnosed at a more advanced stage and tends to be triple negative and they are associated with a worse DFS and overall survival. Early detection during pregnancy may improve outcome.


Assuntos
Neoplasias de Mama Triplo Negativas/diagnóstico , Neoplasias de Mama Triplo Negativas/mortalidade , Adulto , Intervalo Livre de Doença , Feminino , Humanos , Pessoa de Meia-Idade , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico , Complicações Neoplásicas na Gravidez/metabolismo , Complicações Neoplásicas na Gravidez/mortalidade , Complicações Neoplásicas na Gravidez/patologia , Prognóstico , Estudos Prospectivos , Receptor ErbB-2/metabolismo , Receptores Estrogênicos/metabolismo , Receptores de Progesterona/metabolismo , Estudos Retrospectivos , Arábia Saudita , Taxa de Sobrevida , Centros de Atenção Terciária , Neoplasias de Mama Triplo Negativas/metabolismo , Neoplasias de Mama Triplo Negativas/patologia , Adulto Jovem
20.
Femina ; 47(1): 55-60, 20190131. ilus
Artigo em Português | LILACS | ID: biblio-1046493

RESUMO

O câncer do colo do útero é o câncer mais comum na gravidez, com uma estimativa de 1 a 12 casos por 10.000 gestações. Com a melhora do rastreio do câncer do colo do útero e uma tendência feminina de engravidar em idade mais avançada, observa-se que cerca de 43% das pacientes diagnosticadas com câncer do colo do útero têm menos de 45 anos e 20% a 28% são menores de 40 anos. O diagnóstico e o tratamento da doença na gravidez são difíceis e desafiadores, pois geram angústia para a gestante, sua família e os profissionais de saúde. Novos estudos destacam que a preservação da fertilidade e a qualidade de vida estão se tornando preocupações cada vez mais importantes de mulheres jovens com câncer e que os procedimentos cirúrgicos devem ser menos invasivos. O comitê de oncologia da FIGO revisou o sistema de estadiamento do câncer do colo do útero. Este artigo discute o diagnóstico e tratamento do câncer do colo do útero com base no estágio da doença, incluindo atenção a questões de fertilidade e qualidade de vida.(AU)


Cervical cancer is the most common cancer in pregnancy, with an estimated 1-12 cases per 10,000 pregnancies. With improved cervical cancer screening and a tendency to become pregnant at a later age, it is noted that about 43% of patients diagnosed with cervical cancer are younger than 45 and 20-28% are younger than 40 years. Diagnosis and treatment of the disease in pregnancy are difficult and challenging, as they create distress for pregnant women, their families and health professionals. New studies highlight that preserving fertility and quality of life are becoming increasingly important concerns for young women with cancer and that surgical procedures should be less invasive. The FIGO oncology committee reviewed the staging system for cervical cancer. This article discusses the diagnosis and treatment of cervical cancer based on the stage of the disease, including attention to issues of fertility and quality of life.(AU)


Assuntos
Humanos , Feminino , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Neoplasias do Colo do Útero/cirurgia , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/radioterapia , Neoplasias do Colo do Útero/diagnóstico por imagem , Prognóstico , Neoplasias do Colo do Útero/mortalidade , Neoplasias do Colo do Útero/epidemiologia , Gravidez de Alto Risco
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