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1.
J Chromatogr A ; 1609: 460437, 2020 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-31409488

RESUMO

Thermal papers (e.g. point of sale receipts, adhesive labels, tickets) significantly contribute to contamination of paper material cycles and the environment with substances of (eco-) toxicological concern. In particular, they contain color developers like endocrine disrupting bisphenols in typical concentrations of about 1-2 percent per weight (wt%). Bisphenol A (BPA) was used as the common color developer over the last decades, but it will be restricted for thermal paper application in the European Union to a limit of 0.02 wt% from 2020 onwards. Consequently, a variety of BPA substituents such as bisphenol S (BPS) and its derivatives gain importance in thermal paper application. In this study, a rapid, reliable and cost-effective method for identification and quantification of BPA, alternative color developers and related substances like sensitizers is presented based on HPLC separation coupled with diode array detection (DAD) and Corona charged aerosol detection (CAD). Quantification was performed with regard to the intended use of the substances in thermal papers. Besides traditional UV external calibration using reference standards, alternative quantification approaches, in particular UV chromophore concentration for BPS derivatives and CAD universal response technique for low-volatile color developers, were applied and compared in order to allow quantification without reference substances. A market analysis for intended used color developers and sensitizers was performed on thermal paper samples (n = 211) collected in Germany during 2018 and 2019. Pergafast 201 (in 41.7% of the samples) was the most common color developer with concentrations above 0.02 wt%, followed by BPA (36.0%), BPS (13.3%) and other BPS derivatives known as D8, D-90, BPS-MAE and TGSA, that are mainly present in adhesive labels. Sensitizers were determined in over 90% of the samples.


Assuntos
Aerossóis/análise , Compostos Benzidrílicos/análise , Marketing , Papel , Fenóis/análise , Temperatura Ambiente , Compostos Benzidrílicos/química , Calibragem , Cromatografia Líquida de Alta Pressão , Cromatografia de Fase Reversa , Cor , Disruptores Endócrinos/análise , União Europeia , Alemanha , Limite de Detecção , Modelos Lineares , Fenóis/química , Padrões de Referência , Sulfonas
2.
Talanta ; 206: 120179, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31514881

RESUMO

In this work, the magnetic amino-functionalized microporous organic network composites (Fe3O4@MON-NH2) were rational designed and facile synthesized for magnetic solid phase extraction (MSPE) of endocrine disrupting chemicals (EDCs), followed by their analysis with high-performance liquid chromatography. The incorporation of amino groups (hydrogen bonding sites) into hydrophobic MON-NH2 networks led to their good enrichment for four typical EDCs bisphenol A (BPA), 4-alpha-cumylphenol (4-α-CP), 4-tert-octylphenol (4-t-OP) and 4-nonylphenol (4-NP) relying on the pre-designed hydrogen bonding, π-π and hydrophobic interactions. The combination of MON-NH2 shell and magnetic Fe3O4 core provided a fast extraction of BPA, 4-α-CP, 4-t-OP and 4-NP from matrix solution. Under the optimal conditions, the developed method offered good linearity (R2 > 0.990) in the range of 0.05-1000 µg L-1, low limits of detection (S/N = 3) of 0.015-0.030 µg L-1 and large enrichment factors of 172-197 for the studied EDCs. The maximum adsorption capacities of BPA, 4-α-CP, 4-t-OP and 4-NP were 124.1, 105.6, 116.6 and 117.9 mg g-1, respectively. The Fe3O4@MON-NH2 gave larger selectivity for other polar phenols than non-polar polycyclic aromatic hydrocarbons, revealing the dominant role of hydrogen bonding interaction during the extraction and the potential of Fe3O4@MON-NH2 for other polar phenols. The developed method was successfully applied for the analysis of EDCs in water, orange juice and beverage bottle samples with the recoveries of 80.3-109.5%. These results revealed the potential of functional MONs as efficient adsorbents in sample pretreatment.


Assuntos
Disruptores Endócrinos/análise , Contaminação de Alimentos/análise , Nanopartículas de Magnetita/química , Poluentes Químicos da Água/análise , Adsorção , Compostos Benzidrílicos/análise , Cromatografia Líquida de Alta Pressão , Citrus sinensis/química , Embalagem de Alimentos , Sucos de Frutas e Vegetais/análise , Lagos/análise , Limite de Detecção , Fenóis/análise , Rios/química , Extração em Fase Sólida/métodos
3.
Artigo em Inglês | MEDLINE | ID: mdl-31881513

RESUMO

Bisphenol A (BPA), a known potential endocrine disrupting compound (EDC) is expected to be present in low quantities in canned food due to its migration from the inner surface coating of cans made of epoxy resins. A selective and confirmatory analytical method, based on microwave assisted extraction (MAE), molecularly imprinted solid phase extraction (MISPE) using a polymer prepared by a non-covalent molecular imprinting technique and liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI/MS) was developed for the determination of BPA in canned pineapple, tuna and mushrooms. First, the effect of the loading medium of hydro- organic solutions on the binding of BPA and its deuterated analogue on the MISPE sorbent was investigated. Subsequently, the effects of the experimental conditions of the microwave assisted extraction (solvent, sample mass/solvent volume, time and temperature) on the obtained recovery of BPA from canned food were assessed and the parameters were optimized to provide maximum recovery and selectivity. It was demonstrated that the combination of MAE with MISPE permits the use of a selective extraction solvent (methanol/water, 4/6, v/v), simplifying the sample preparation steps and enhancing sample clean-up of complex food matrices. The method was validated in different food matrices, using BPA-d16 as internal standard and quantitative relative recoveries were determined. The precision (RSD %) of the method ranged from 7% to 10% and the limit of detection was at low ng/g level for all food matrices. The determined concentration of BPA in commercial canned samples ranged between 7.3 and 42.3 ng/g.


Assuntos
Compostos Benzidrílicos/análise , Alimentos em Conserva/análise , Impressão Molecular/métodos , Fenóis/análise , Extração em Fase Sólida/métodos , Cromatografia Líquida de Alta Pressão/métodos , Limite de Detecção , Modelos Lineares , Micro-Ondas , Reprodutibilidade dos Testes , Espectrometria de Massas por Ionização por Electrospray/métodos
4.
Chemosphere ; 238: 124621, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31454740

RESUMO

Present study prepared a new magnetic and thermo dual-responsive core-shell nanomaterial (Fe@SiO2@poly(N-isopropylacrymide-co-methacrylic acid, Fe@SiO2@PNIPAM-co-MAA), which was characterized by transmission electron microscopy and X-ray diffraction techniques. The new nanomaterials integrated with the magnetism of nanoscale zero valent iron material and thermo-response of the copolymers, and were utilized to investigate the adsorption capacity for typical phenols such as bisphenol A, phenol and hydroquinone from water samples, and the results showed that the magnetic and thermo dual-responsive core-shell nanomaterial exhibited good adsorption ability to typical phenols. Based on these, a sensitive method was developed for the determination of bisphenol A, phenol and hydroquinone using as-prepared magnetic nanoparticles as the magnetic solid phase extraction sorbent prior to high performance liquid chromatography coupled with variable wavelength detection. Under the optimal conditions, linear linearity was obtained over the range of 0.1-500 µg L-1 with the correlation coefficients (r2) above 0.996. The detection limits of three analytes were in the range of 0.019-0.031 µg L-1, and the precisions were all less than 4.8% (n = 6). The developed method was evaluated with real water samples and excellent spiked recoveries in the range of 94.0-105.4% were achieved. These results indicated that the proposed method was a robust analytical tool and a useful alternative for routine analysis of such pollutants.


Assuntos
Compostos Benzidrílicos/isolamento & purificação , Hidroquinonas/isolamento & purificação , Magnetismo , Nanoestruturas/química , Fenol/isolamento & purificação , Fenóis/isolamento & purificação , Extração em Fase Sólida/métodos , Poluentes Químicos da Água/isolamento & purificação , Compostos Benzidrílicos/análise , Hidroquinonas/análise , Fenol/análise , Fenóis/análise , Temperatura Ambiente , Poluentes Químicos da Água/análise
5.
Environ Monit Assess ; 192(1): 20, 2019 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-31820108

RESUMO

The concept of the study resulted from the lack of accurate data on the toxicity of bisphenol F (BPF) coinciding with the need for immediate changes in the global economic policy eliminating the effects of environmental contamination with bisphenol A (BPA). The aim of the experiment was to determine the scale of the previously unstudied inhibitory effect of BPF on soil biochemical activity. To this end, in a soil subjected to increasing BPF pressure at three contamination levels of 0, 5, 50 and 500 mg BPF kg-1 DM, responses of soil enzymes, dehydrogenases, catalase, urease, acid phosphatase, alkaline phosphatase, arylsulphatase and ß-glucosidase, were examined. Moreover, the study suggested a potentially effective way of biostimulating the soil by means of bioaugmentation with a consortium of four bacterial species: Pseudomonas umsongensis, Bacillus mycoides, Bacillus weihenstephanensis and Bacillus subtilis, and the following fungal species: Mucor circinelloides, Penicillium daleae, Penicillium chrysogenum and Aspergillus niger. It was found that BPF was a controversial BPA analogue due to the fact that it contributed to the inhibition of all the enzyme activities. Dehydrogenases proved to be the most sensitive to bisphenol contamination of the soil. The addition of 5 mg BPF kg-1 DM of soil triggered an escalation of the inhibition comparable to that for the other enzymes only after exposing them to the effects of 50 and 500 mg BPF kg-1 DM of soil. Moreover, BPF generated low activity of urease, acid phosphatase, alkaline phosphatase and ß-glucosidase. Bacterial inoculum increased the activity of urease, ß-glucosidase, catalase and alkaline phosphatase. Seventy-six percent of BPF underwent biodegradation during the 5 days of the study.


Assuntos
Compostos Benzidrílicos/análise , Biodegradação Ambiental , Monitoramento Ambiental , Fenóis/análise , Microbiologia do Solo , Poluentes do Solo/análise , Arilsulfatases , Bacillus/efeitos dos fármacos , Bactérias/efeitos dos fármacos , Fungos/efeitos dos fármacos , Oxirredutases , Solo , Estrobilurinas , Urease
6.
J Food Sci ; 84(11): 3303-3311, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31671224

RESUMO

Seven bisphenols, endocrine-disruptor chemicals, were analytically determined for risk assessment in 52 large-consumption beverages collected from the Italian market. The analytes under examination were bisphenol A, bisphenol F, bisphenol E, bisphenol B, bisphenol AF, bisphenol A diglycidyl ether, and bisphenol M. The concentration levels of all bisphenols detected ranged from

Assuntos
Compostos Benzidrílicos/análise , Bebidas/análise , Disruptores Endócrinos/análise , Fenóis/análise , Cerveja/análise , Compostos de Epóxi/análise , Contaminação de Alimentos/análise , Alimentos em Conserva/análise , Humanos , Itália
7.
Environ Health Perspect ; 127(11): 117004, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31774309

RESUMO

BACKGROUND: Newborns in neonatal intensive care units (NICUs) are in contact with a variety of medical products whose production might include synthetic chemicals with hormonal activity. OBJECTIVES: Our aim was to assess the content of bisphenol A (BPA) and parabens (PBs) and the hormone-like activities of a subset of medical products commonly used in NICUs in prolonged intimate contact with NICU newborns. METHODS: Fifty-two NICU items were analyzed, determining the concentrations of BPA and PBs [methyl- (MeP), ethyl- (EtP), propyl- (PrP), and butylparaben (BuP)] and using the E-Screen and PALM-luciferase assays to measure the in vitro (anti-)estrogenic and (anti-)androgenic activity, respectively, of the extracts. Items found to have elevated BPA/PB content or hormone-like activities were further extracted using leaching methodologies. RESULTS: BPA was found in three-fifths and PBs in four-fifths of tested NICU items, and ∼25% and ∼10% of extracts evidenced estrogenic and anti-androgenic activity, respectively. The highest BPA content was found in the three-way stopcock (>7.000 ng/g), followed by patterned transparent film dressing, gastro-duodenal feeding tubes, sterile gloves, single-lumen umbilical catheters, and intravenous (IV) infusion extension sets (concentrations ranged from 100 to 700 ng/g BPA). A total PB concentration (∑PBs) >100 ng/g was observed in several items, including light therapy protection glasses, patterned transparent film dressing, winged IV catheters, IV infusion extension sets, and textile tape. The highest estrogenic activity [>450 pM estradiol equivalent (E2eq)] was found in small dummy nipples, three-way stopcocks, and patterned transparent film dressing and the highest anti-androgenic activity [>5 mM procymidone equivalent units per gram (Proceq/g)] in small dummy nipples and three-way stopcocks. DISCUSSION: According to these findings, neonates might be exposed to multiple sources of BPA and PBs in NICUs via inhalation, dermal, oral, and IV/parenteral routes. There is a need to address the future health implications for these extremely vulnerable patients and to adopt precautionary preventive measures as a matter of urgency. https://doi.org/10.1289/EHP5564.


Assuntos
Compostos Benzidrílicos/análise , Exposição Ambiental/análise , Unidades de Terapia Intensiva Neonatal , Parabenos/análise , Fenóis/análise , Suplementos Nutricionais/análise , Equipamentos e Provisões , Humanos , Recém-Nascido , Pomadas/análise , Têxteis/análise
8.
Environ Sci Pollut Res Int ; 26(36): 36410-36422, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31728944

RESUMO

This study demonstrated, for the first time, Fe(III)/peroximonosulphate (PMS) could be an efficient advanced oxidation process (AOP) for wastewater treatment. Bisphenol A (BPA) was chosen as a model pollutant in the present study. Fe(III)-activated PMS system proved very effective to eliminate 92.18% of BPA (20 mg/L) for 30-min reaction time at 0.50 mM PMS, 1.5 g/L Fe(III), pH 7.0. The maximum degradation of BPA occurred at neutral pH, while it was suppressed at both strongly acidic and alkaline conditions. Organic and inorganic ions can interfere with system efficiency either positively or negatively, so their interaction was thoroughly investigated. Furthermore, the presence of organic acids also affected BPA degradation rate, especially the addition of 10 mM citric acid decreased the degradation rate from 92.18 to 66.08%. Radical scavenging experiments showed that SO4•- was the dominant reactive species in Fe(III)/PMS system. A total of 5 BPA intermediates were found by using LC/MS. A possible degradation pathway was proposed which underwent through bridge cleavage and hydroxylation processes. Acute toxicity of the BPA degradation products was assessed using Escherichia coli growth inhibition test. These findings proved to be promising and economical to deal with wastewater using iron mineral for the elimination of organic pollutants. Graphical abstract.


Assuntos
Compostos Benzidrílicos/análise , Compostos Férricos/química , Peróxidos/química , Fenóis/análise , Águas Residuárias/química , Poluentes Químicos da Água/análise , Purificação da Água/métodos , Catálise , Oxirredução
9.
Anal Bioanal Chem ; 411(29): 7807-7815, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31745613

RESUMO

Given the gigantic harmfulness of bisphenol A (BPA), a novel and ultrasensitive aptasensor, which employs the truncated BPA aptamer, click chemistry, and activators generated by electron transfer for atom transfer radical polymerization (AGET ATRP), was developed herein for the quantitative determination of BPA. Firstly, hairpin DNAs (hairpins) with a thiol at the 5' end and an azide group at the 3' end were conjugated with aminated magnetic beads (MBs) through heterobifunctional cross-linkers. BPA truncated aptamer (ssDNA-A) hybridizes with its complementary single-stranded DNA (ssDNA-B) to form double-stranded DNA. In the presence of BPA, ssDNA-A specifically captures BPA, and then ssDNA-B is released. Subsequently, the ssDNA-B hybridizes with hairpins to expose the azide group near the surface of the MBs. Then, propargyl-2-bromoisobutyrate (PBIB), the initiator of AGET ATRP containing alkynyl group, was conjugated with azide group of hairpins via the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Consequently, a large number of fluorescein-o-acrylate (FA) were introduced to the MBs through AGET ATRP, resulting in that the fluorescence intensity was increased dramatically. Obviously, the fluorescence intensity was especially sensitive to the change of BPA concentration, and this method can be used in quantitative determination of BPA. Under optimal conditions, a broad liner range from 100 fM to 100 nM and a low limit of detection (LOD) of 6.6 fM were obtained. Moreover, the method exhibits not only excellent specificity for BPA detection over BPA analogues but high anti-interference ability in real water sample detection, indicating that it has huge application prospect in food safety and environment monitoring.


Assuntos
Aptâmeros de Nucleotídeos/química , Compostos Benzidrílicos/análise , Fenóis/análise , Poluentes Químicos da Água/análise , Limite de Detecção , Reprodutibilidade dos Testes , Espectrometria de Fluorescência
10.
Artigo em Inglês | MEDLINE | ID: mdl-31609683

RESUMO

Based on response surface methodology, empirical models were built to predict the influence of can processing (heat treatment) and storage conditions (time and temperature) on the migration of bisphenol compounds from the inner lacquer of tinplate cans (4 brands) into several food simulants. Analysis using liquid chromatography revealed the presence of BADGE.2H2O and BPA in all samples. Models were significant in fitting the levels of these two bisphenols in food simulants depending on the input variables, with excellent adjusted coefficients of determination. Their prediction performance was validated through running new data sets. Further comparison of predicted values with bisphenols levels measured in canned vegetables revealed that the proposed models are conservative. By the desirability of the response output, the models are capable of proposing the range of can processing and storage conditions that limit migration for further compliance with the regulation. The proposed approach could be a convenient tool for the industries to control processing conditions in order to ensure the conformity of canned foods.


Assuntos
Compostos Benzidrílicos/análise , Pesquisa Empírica , Contaminação de Alimentos/análise , Alimentos em Conserva/análise , Modelos Biológicos , Fenóis/análise , Embalagem de Alimentos , Esterilização , Propriedades de Superfície
11.
Ecotoxicol Environ Saf ; 185: 109739, 2019 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-31586847

RESUMO

Silver nanowires (AgNWs) are widely produced in many electronic and optical products, and could be inevitably discharged into the aquatic environments. Sulfidation is one of the most important transformation processes of AgNWs, and could significantly affect their fate and interactions with other pollutants in aquatic environment. In the present study, the sulfidation products of AgNWs with different atomic ratio of Ag and S were prepared under environmentally relevant conditions. The crystal structure, elemental composition, morphology and size of the sulfidation products were comprehensively characterized by powder X-ray diffraction, UV-vis spectroscopy, X-ray photoelectron spectroscopy and transmission electron microscope. The products were heterostructured nanowires and the Ag2S/Ag molar ratio increased with extension of the reaction time. The produced Ag2S-Ag nanowires displayed a good photocatalytic activity and facilitated the degradation of the copresent organic pollutant bisphenol A (BPA) under simulated sunlight irradiation. As sulfidation time increased, more Ag2S was generated and the Ag2S-Ag composites displayed high promotion effect on BPA degradation. This effect could be ascribed to the favorable synergistic effects between Ag2S and AgNWs, such as high electron-hole separation efficiency and low charge transfer resistance. The chemical scavenger experiments demonstrated that superoxide anion radicals and photogenerated holes in the sulfidation products of AgNWs could be the main reactive species for photocatalytic degradation.


Assuntos
Compostos Benzidrílicos/análise , Nanofios/química , Fenóis/análise , Prata/química , Sulfetos/química , Luz Solar , Poluentes Químicos da Água/análise , Compostos Benzidrílicos/efeitos da radiação , Catálise , Fenóis/efeitos da radiação , Poluentes Químicos da Água/efeitos da radiação
12.
Se Pu ; 37(11): 1185-1192, 2019 Nov 08.
Artigo em Chinês | MEDLINE | ID: mdl-31642271

RESUMO

A method was developed for the rapid determination of bisphenol A (BPA) and eight structural analogs in children's plastic water bottles by online enrichment coupled with high performance liquid chromatography-fluorescence detection (HPLC-FLD). The correlation coefficients of the nine bisphenols were greater than 0.998. The limits of detection (LOQs) ranged from 0.13 ng/L to 66.7 ng/L. The recoveries ranged from 90.7% to 112.4% (RSD<11.3%, n=6). This method was applied to monitor nine bisphenols in children's water bottles. The results showed that except 4,4'-(9H-fluoren-9-ylidene)bisphenol (BPFL), all the remaining eight bisphenols were detected in different water bottles. The amounts of bisphenols leached increased with the increase of soaking time, and decreased after washing several times at 100℃. The proposed strategy is rapid, sensitive, reliable and eco-friendly, and is suitable for the simultaneous analysis of new bisphenols in water samples.


Assuntos
Compostos Benzidrílicos/análise , Água Potável/análise , Embalagem de Alimentos , Fenóis/análise , Cromatografia Líquida de Alta Pressão , Humanos
13.
Ecotoxicol Environ Saf ; 186: 109778, 2019 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-31627095

RESUMO

Freshness protection packages and preservative films are widely used food-contact plastic made of polyethylene. Diode array detector (DAD), charged aerosol detector (CAD) and evaporative light-scattering detector (ELSD) were evaluated for determination of 6 bisphenols (bisphenol A, bisphenol S, bisphenol F, bisphenol B, bisphenol AF and tetrabromobisphenol A.) in polyethylene. DAD presented better parameters including limit of quantification (LOQs) ranging from 0.05 to 0.5 µg/g with relative standard deviations (RSDs, n = 5) lower than 1% at two concentration levels. CAD and ELSD are universal detectors with relative consistent response parameters for different analogues which have potential application by using single calibrant for quantification of multiple analytes. Matrix effects were barely observed on three detectors. Samples of freshness protection packages and preservative films were further analyzed and preliminary profiles of bisphenols in products from Beijing market was obtained. Bisphenol S have become most abundant analogue instead of bisphenol A in investigated products.


Assuntos
Compostos Benzidrílicos/análise , Cromatografia Líquida de Alta Pressão/métodos , Embalagem de Alimentos , Fenóis/análise , Polietileno/química , Sulfonas/análise , Cromatografia Líquida de Alta Pressão/instrumentação , Limite de Detecção
14.
Analyst ; 144(19): 5691-5699, 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31508622

RESUMO

Herein, a novel aptasensor was constructed for ultrasensitive detection of bisphenol A (BPA). In this method, an electrochemically mediated atom transfer radical polymerization (eATRP) signal amplification strategy was applied to BPA detection for the first time. The 5'-end modified sulfhydryl group and the 3'-end modified azide group hairpin DNA were immobilized on a gold electrode through an Au-S bond. The double-stranded DNA was formed by the hybridization of an aptamer and a single-stranded DNA partially paired with the hairpin DNA. In the presence of BPA, the aptamer combined with BPA and the single-stranded DNA was released to open the hairpin structure, making the azide groups at the 3' end exposed. Subsequently the initiator of eATRP was introduced into hairpin DNA through click chemistry reaction and eATRP was conducted for the polymerization of the electroactive probe ferrocene methyl methacrylate (FMMA). As a result, the ultrasensitive detection of BPA was realized, and the detection limit of this aptasensor was as low as 59 aM and a good selectivity was obtained in the presence of 100-fold structural analogs. The application of this aptasensor was evaluated by detecting BPA in pure water samples, and recoveries were in the range of 95.23-98.40%, holding promising applications in biological analysis.


Assuntos
Aptâmeros de Nucleotídeos/química , Compostos Benzidrílicos/análise , DNA de Cadeia Simples/química , Fenóis/análise , Aptâmeros de Nucleotídeos/genética , Técnicas Biossensoriais/métodos , DNA de Cadeia Simples/genética , Técnicas Eletroquímicas/instrumentação , Técnicas Eletroquímicas/métodos , Eletrodos , Compostos Ferrosos/química , Ouro/química , Sequências Repetidas Invertidas , Limite de Detecção , Metilmetacrilato/química , Hibridização de Ácido Nucleico , Polimerização , Reprodutibilidade dos Testes , Poluentes Químicos da Água/análise
15.
Environ Pollut ; 255(Pt 1): 113140, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31541833

RESUMO

This review aims to gather and summarize information about the occurrence of emerging contaminants and antibiotic resistance genes in environmental matrices in Latin America. We aim to contribute to future research by compiling a list of priority pollutants adjusted to the needs and characteristics of Latin America, according to the data presented in this study. In order to perform a comprehensive research and secure a representative and unbiased amount of quality data concerning emerging contaminants in Latin America, the research was performed within the Scopus® database in a time frame from 2000 to July 2019. The countries with higher numbers of published articles were Brazil and México, while most studies were performed in the surroundings of Mexico City and in Southern and Southeastern Brazil. The main investigated environmental matrices were drinking water and surface water. The presence of antibiotic resistance was frequently reported, mainly in Brazil. Monitoring efforts should be performed in other countries in Latin America, as well as in other regions of Brazil and México. The suggested priority list for monitoring of emerging contaminants in Latin America covers: di(2-ethylhexyl) phthalate (DEHP), bisphenol-A (BP-A), 4-nonylphenol (4-NP), triclosan (TCS), estrone (E1), estradiol (E2), ethinylestradiol (EE2), tetracycline (TC), amoxicillin (AMOX), norfloxacin (NOR), ampicillin (AMP) and imipenem (IMP). We hope this list serves as a basis for the orientation of the future research and monitoring projects to better understand the distribution and concentration of the listed emerging substances.


Assuntos
Antibacterianos/análise , Farmacorresistência Bacteriana/efeitos dos fármacos , Estrogênios/análise , Águas Residuárias/química , Poluentes Químicos da Água/análise , Purificação da Água/métodos , Compostos Benzidrílicos/análise , Brasil , Cidades , Dietilexilftalato/análise , Poluentes Ambientais , Estradiol/análise , Estrona/análise , Etinilestradiol/análise , América Latina , Linestrenol/análise , México , Fenóis/análise , Triclosan/análise
16.
Mar Pollut Bull ; 149: 110551, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31543489

RESUMO

The chemical industrial zone located along the Xiaoqing River wetlands adjacent to Bohai Sea is one of the largest production bases for brominated flame retardants in China. Herein, high levels of bisphenol-A, tetrabromobisphenol-A (TBBPA), tribromobisphenol-A, dibromobisphenol-A, and monobromobisphenol-A were detected in sediment, soil, and water samples of this zone in the range of below method detection limit (

Assuntos
Compostos Benzidrílicos/análise , Fenóis/análise , Poluentes Químicos da Água/análise , China , Monitoramento Ambiental/métodos , Estuários , Retardadores de Chama/análise , Sedimentos Geológicos/análise , Halogenação , Bifenil Polibromatos/análise , Rios , Água do Mar/análise , Poluentes do Solo/análise
17.
Mater Sci Eng C Mater Biol Appl ; 105: 110048, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31546367

RESUMO

A simple, inexpensive, highly sensitive, selective, and novel electrochemical method was developed for determination of the Bisphenol A in samples of tap water, blood serum, and urine using a bentonite-modified carbon paste electrode. The graphite, bentonite and the working electrodes (without and chemically modified) were characterized by scanning electron microscopy, infrared absorption spectroscopy, and X-ray diffraction. The electrodes were electrochemically characterized using cyclic voltammetry, square wave voltammetry, and electrochemical impedance spectroscopy. The studied electrochemical variables were: electrode area, standard heterogeneous rate constant, charge transfer coefficient and double-layer capacitance. The bentonite as a sensor modifier had a strong influence on these variables. For the development of the methodology to quantify Bisphenol A, the instrumental parameters (frequency, amplitude, and step potential) and experimental parameters (pH, bentonite quantity) were optimized. The analytical curve to Bisphenol showed a linear response of the oxidation peak current intensity vs. the concentration in the range of 6.8 × 10-10 to 1.5 × 10-8 mol mL-1, with a limit of detection (LOD) of 2.11 × 10-11 mol mL-1 and limit of quantification (LOQ) of 7.04 × 10-11 mol mL-1. Recovery experiments were performed by adding known amounts of Bisphenol A in tap water, blood serum, and urine samples. Recovery rates using the standard addition method were in the range of 97.8-101.8%. The results demonstrated the method feasibility for quantifying Bisphenol A in these samples.


Assuntos
Bentonita/química , Compostos Benzidrílicos/análise , Técnicas Eletroquímicas , Fenóis/análise , Eletrodos , Grafite/química , Limite de Detecção , Oxirredução
18.
Nutrients ; 11(9)2019 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-31500194

RESUMO

Bisphenol A (BPA) is the most well-known compound from the bisphenol family. As BPA has recently come under pressure, it is being replaced by compounds very similar in structure, but data on the occurrence of these BPA analogues in food and human matrices are limited. The main objective of this work was to investigate human exposure to BPA and analogues and the associated health effects. We performed a literature review of the available research made in humans, in in vivo and in vitro tests. The findings support the idea that exposure to BPA analogues may have an impact on human health, especially in terms of obesity and other adverse health effects in children.


Assuntos
Tecido Adiposo/efeitos dos fármacos , Adiposidade/efeitos dos fármacos , Compostos Benzidrílicos/efeitos adversos , Disruptores Endócrinos/efeitos adversos , Metabolismo Energético/efeitos dos fármacos , Contaminação de Alimentos , Obesidade/induzido quimicamente , Fenóis/efeitos adversos , Tecido Adiposo/metabolismo , Tecido Adiposo/fisiopatologia , Animais , Compostos Benzidrílicos/análise , Disruptores Endócrinos/análise , Humanos , Obesidade/metabolismo , Obesidade/fisiopatologia , Fenóis/análise , Medição de Risco , Fatores de Risco
19.
Artigo em Inglês | MEDLINE | ID: mdl-31500322

RESUMO

Due to the widespread use of bisphenol analogues (BPs) as alternatives to bisphenol A (BPA), considerable attention for health risk has been shown in aquatic ecosystems. The occurrence and distribution of six BPs were researched in a soluble phase (<10-3 µm), colloidal phase (10-3 µm to 1 µm), and suspended particulate matter (SPM >1 µm) in a water diversion project of Nanjing, China. Except for bisphenol Z, all BPs were detected in two or three phases, where the total concentrations of detected BPs were 161-613 ng/L, 5.19-77.2 ng/L, and 47.5-353 ng/g for the soluble phase, colloidal phase, and SPM, respectively. Among the detected compounds, BPA is still the dominant BPs in the soluble and colloidal phases, which is followed by bisphenol-S , while bisphenol-AF was the major contaminant in SPM, followed by BPA. The mean contribution proportions of colloids were 1-2 orders of magnitude higher than SPM, which suggests that colloids have a clear impact on regulating BPs' environmental behaviors. In terms of spatial distribution, the water diversion project could reduce the pollution levels of BPs, which might further affect the ecological security of the Yangtze River.


Assuntos
Compostos Benzidrílicos/análise , Cicloexanos/análise , Fenóis/análise , Rios/química , Sulfonas/análise , Poluentes Químicos da Água/análise , Água/química , China , Monitoramento Ambiental/métodos
20.
Environ Monit Assess ; 191(10): 619, 2019 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-31493146

RESUMO

Presented in this study is a simple but efficient switchable polarity solvent microextraction strategy for etrimfos preconcentration from water and food samples for quantification by gas chromatography mass spectrometry. Repeatability of the extraction process and instrumental measurements were enhanced by using deuterated bisphenol A as internal standard. Significant parameters of the extraction method were fitted into an experimental design model to study the effects of parameters on extraction output, as well as mutual effects of combined parameters. The design model was formed with 51 experimented data obtained from the combination of sodium hydroxide volume, switchable solvent volume, and vortex period at three levels. The method was validated by applying optimum conditions attained from the model predictor. The detection limit was found to be 1.3 ng/mL and it corresponded to an enhancement factor of about 54 folds when compared to direct GC-MS measurement. Etrimfos was not detected in the water and food samples tested but the results (92-107%) obtained from spiked recovery experiments established that etrimfos when present in the selected matrices can be accurately and precisely quantified.


Assuntos
Poluentes Ambientais/análise , Análise de Alimentos/métodos , Contaminação de Alimentos/análise , Cromatografia Gasosa-Espectrometria de Massas , Microextração em Fase Líquida , Organotiofosfatos/análise , Água/química , Compostos Benzidrílicos/análise , Compostos Benzidrílicos/normas , Poluentes Ambientais/química , Poluentes Ambientais/isolamento & purificação , Limite de Detecção , Organotiofosfatos/química , Organotiofosfatos/isolamento & purificação , Fenóis/análise , Fenóis/normas , Reprodutibilidade dos Testes , Projetos de Pesquisa , Solventes/química
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